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Wyświetlanie 1-5 z 5
Tytuł :
Design, Synthesis and In Vitro Cytotoxic Activity of New 6,9-Disubstituted Purine Analogues.
Autorzy :
Kucukdumlu A
Tuncbilek M
Guven EB
Atalay RC
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Źródło :
Acta chimica Slovenica [Acta Chim Slov] 2020 Mar; Vol. 67 (1), pp. 70-82.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Purines/*pharmacology
Antineoplastic Agents/chemical synthesis ; Cell Line, Tumor ; Cladribine/pharmacology ; Drug Design ; Drug Screening Assays, Antitumor ; Fluorouracil/pharmacology ; Humans ; Molecular Structure ; Purines/chemical synthesis ; Vidarabine/analogs & derivatives ; Vidarabine/pharmacology
Czasopismo naukowe
Tytuł :
Synthesis of novel 6-substituted amino-9-(β-d-ribofuranosyl)purine analogs and their bioactivities on human epithelial cancer cells.
Autorzy :
Tuncbilek M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Ankara, Turkey. Electronic address: .
Kucukdumlu A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Ankara, Turkey.
Guven EB; Department of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey.
Altiparmak D; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Ankara, Turkey.
Cetin-Atalay R; Cancer Systems Biology Laboratory, Graduate School of Informatics, ODTU, Ankara 06800, Turkey. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Feb 01; Vol. 28 (3), pp. 235-239. Date of Electronic Publication: 2018 Jan 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Purine Nucleosides/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Cladribine/pharmacology ; Drug Screening Assays, Antitumor ; Fluorouracil/pharmacology ; Humans ; Molecular Structure ; Purine Nucleosides/chemical synthesis ; Purine Nucleosides/chemistry ; Purine Nucleosides/pharmacokinetics ; Vidarabine/analogs & derivatives ; Vidarabine/pharmacology
Czasopismo naukowe
Tytuł :
Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status.
Autorzy :
Durmaz I; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey. Electronic address: .
Guven EB; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey. Electronic address: .
Ersahin T; Cancer Systems Biology Laboratory, Graduate School of Informatics, METU, 06800 Ankara, Turkey. Electronic address: .
Ozturk M; Izmir Biomedicine and Genome Center, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Electronic address: .
Calis I; Department of Pharmacognosy, Faculty of Pharmacy, Near East University, Lefkosa (Nicosia), N. Cyprus. Electronic address: .
Cetin-Atalay R; Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, Turkey; Cancer Systems Biology Laboratory, Graduate School of Informatics, METU, 06800 Ankara, Turkey. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2016 Jan 15; Vol. 23 (1), pp. 42-51. Date of Electronic Publication: 2015 Dec 12.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*pathology
Lanatosides/*pharmacology
Liver Neoplasms/*pathology
PTEN Phosphohydrolase/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation ; Digitalis/chemistry ; Humans ; Mice ; Mice, Nude ; Oxidative Stress ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Synthesis of novel substituted purine derivatives and identification of the cell death mechanism.
Autorzy :
Demir Z; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Ankara, Turkey.
Guven EB; Department of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey.
Ozbey S; Department of Engineering Physics, Faculty of Engineering, Hacettepe University, 06800 Beytepe, Ankara, Turkey.
Kazak C; Department of Physics, Faculty of Arts and Sciences, Ondokuz Mayıs University, 55139 Kurupelit, Samsun, Turkey.
Atalay RC; Department of Molecular Biology and Genetics, Bilkent University, 06800 Ankara, Turkey. Electronic address: .
Tuncbilek M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Ankara, Turkey. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2015 Jan 07; Vol. 89, pp. 701-20. Date of Electronic Publication: 2014 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Purines/*chemistry
Purines/*pharmacology
Antineoplastic Agents/chemistry ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HCT116 Cells ; Hep G2 Cells ; Humans ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(β-D-ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells.
Autorzy :
Tuncbilek M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Ankara, Turkey. />Guven EB
Onder T
Cetin Atalay R
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2012 Apr 12; Vol. 55 (7), pp. 3058-65. Date of Electronic Publication: 2012 Mar 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Adenosine/*analogs & derivatives
Antineoplastic Agents/*chemical synthesis
Carcinoma, Hepatocellular/*pathology
Cell Death/*drug effects
Liver Neoplasms/*pathology
Piperazines/*chemical synthesis
Protein Kinase Inhibitors/*chemical synthesis
Purine Nucleosides/*chemical synthesis
Adenosine/chemical synthesis ; Adenosine/chemistry ; Adenosine/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p15/metabolism ; Drug Screening Assays, Antitumor ; Humans ; Phosphorylation ; Piperazines/chemistry ; Piperazines/pharmacology ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Purine Nucleosides/chemistry ; Purine Nucleosides/pharmacology ; Retinoblastoma Protein/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
    Wyświetlanie 1-5 z 5

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