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Wyszukujesz frazę ""HCT116 Cells"" wg kryterium: Temat


Tytuł :
Ring size changes in the development of class I HDAC inhibitors.
Autorzy :
Cho EC; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; Master Program in Clinical Genomics and Proteomics, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Liu CY; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Tang DW; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Lee HY; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1387-1401.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
Histone Deacetylase Inhibitors/*chemistry
Apoptosis/drug effects ; Cell Proliferation/drug effects ; HCT116 Cells ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Ropivacaine inhibits the proliferation and migration of colorectal cancer cells through ITGB1.
Autorzy :
Wang X; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University , Beijing, China.
Li T; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University , Beijing, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 44-53.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement/*drug effects
Cell Proliferation/*drug effects
Colorectal Neoplasms/*metabolism
Integrin beta1/*metabolism
Ropivacaine/*pharmacology
Cell Line, Tumor ; HCT116 Cells ; Humans ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Interleukin-18 promotes the antitumor ability of natural killer cells in colorectal cancer via the miR-574-3p/TGF-β1 axis.
Autorzy :
Li YP; Department of Gastroenterology, Shenzhen People's Hospital Longhua Branch (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China.
Du XR; Department of Gastroenterology, Shenzhen People's Hospital Longhua Branch (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China.
Zhang R; Department of Gastroenterology, Department of Gastroenterology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China.
Yang Q; Department of Gastroenterology, Shenzhen People's Hospital Longhua Branch (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China.
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Źródło :
Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 763-778.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms*/immunology
Colorectal Neoplasms*/metabolism
Killer Cells, Natural*/immunology
Killer Cells, Natural*/metabolism
Interleukin-18/*metabolism
MicroRNAs/*metabolism
Transforming Growth Factor beta1/*metabolism
Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/immunology ; HCT116 Cells ; Humans ; Interleukin-18/pharmacology
Czasopismo naukowe
Tytuł :
Synthesis of some quinazolinones inspired from the natural alkaloid L - norephedrine as EGFR inhibitors and radiosensitizers.
Autorzy :
Ghorab MM; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Abdel-Kader MS; Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.; Department of Pharmacognosy, College of Pharmacy, Alexandria University, Alexandria, Egypt.
Alqahtani AS; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.; Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Soliman AM; Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 218-237.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*chemical synthesis
Phenylpropanolamine/*chemistry
Quinazolinones/*chemical synthesis
Radiation-Sensitizing Agents/*chemical synthesis
Apoptosis/drug effects ; Apoptosis/radiation effects ; Binding Sites ; Cell Line ; Cell Proliferation/drug effects ; Cell Proliferation/radiation effects ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/radiation effects ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/chemistry ; ErbB Receptors/metabolism ; Gamma Rays ; HCT116 Cells ; Hep G2 Cells ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Molecular Docking Simulation ; Phenylpropanolamine/metabolism ; Phenylpropanolamine/pharmacology ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Quinazolinones/metabolism ; Quinazolinones/pharmacology ; Radiation-Sensitizing Agents/metabolism ; Radiation-Sensitizing Agents/pharmacology ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells.
Autorzy :
Li G; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
Zhang C; School of Pharmacy, Zhengzhou University, Zhengzhou, PR China.
Liang W; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
Zhang Y; School of Pharmacy, Zhengzhou University, Zhengzhou, PR China.
Shen Y; School of Pharmacy, Naval Medical University, Shanghai, PR China.
Tian X; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
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Źródło :
Pharmaceutical biology [Pharm Biol] 2021 Dec; Vol. 59 (1), pp. 21-30.
Typ publikacji :
Journal Article
MeSH Terms :
Berberine/*administration & dosage
Colonic Neoplasms/*metabolism
PTEN Phosphohydrolase/*biosynthesis
Phosphatidylinositol 3-Kinases/*biosynthesis
Proto-Oncogene Proteins c-akt/*biosynthesis
Receptor, Notch1/*biosynthesis
TOR Serine-Threonine Kinases/*biosynthesis
A549 Cells ; Antineoplastic Agents/administration & dosage ; Benzoquinones/administration & dosage ; Colonic Neoplasms/drug therapy ; Dose-Response Relationship, Drug ; Drug Synergism ; HCT116 Cells ; Humans ; Lactams, Macrocyclic/administration & dosage ; MCF-7 Cells ; Nylons ; Phosphoinositide-3 Kinase Inhibitors/administration & dosage ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Pyrroles/administration & dosage ; Receptor, Notch1/antagonists & inhibitors ; Signal Transduction/drug effects ; Signal Transduction/physiology ; THP-1 Cells ; TOR Serine-Threonine Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Anticancer potential of limonoids from Swietenia macrophylla: Genotoxic, antiproliferative and proapoptotic effects towards human colorectal cancer.
Autorzy :
Pinto LC; Laboratory of Experimental Neuropathology, Biological Science Institute, Federal University of Pará, Mundurucus street, 4487, Guamá, Belém, Brazil.
Mesquita FP; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000, Rodolfo Teófilo, Fortaleza, Brazil.
Barreto LH; Laboratory of Human Cytogenetics, Biological Science Institute, Federal University of Pará, Augusto Correa Avenue, 01, Guamá, Belém, Brazil.
Souza PFN; Collaborating professor of Biochemistry and Molecular Biology Graduate Program at the Department of Biochemistry and Molecular Biology, Federal University of Ceará.
Ramos INF; Laboratory of Human Cytogenetics, Biological Science Institute, Federal University of Pará, Augusto Correa Avenue, 01, Guamá, Belém, Brazil.
Pinto AVU; Laboratory of Human Cytogenetics, Biological Science Institute, Federal University of Pará, Augusto Correa Avenue, 01, Guamá, Belém, Brazil.
Soares BM; Laboratory of Human Cytogenetics, Biological Science Institute, Federal University of Pará, Augusto Correa Avenue, 01, Guamá, Belém, Brazil.
da Silva MN; Laboratory of Liquid Chromatography, Institute of Exact and Natural Sciences, Federal University of Pará, Augusto Correa Avenue, 01, Guamá, Belém, Brazil.
Burbano RMR; Laboratory of Human Cytogenetics, Biological Science Institute, Federal University of Pará, Augusto Correa Avenue, 01, Guamá, Belém, Brazil.
Montenegro RC; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000, Rodolfo Teófilo, Fortaleza, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119949. Date of Electronic Publication: 2021 Sep 20.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Damage*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Colorectal Neoplasms/*pathology
Limonins/*pharmacology
Meliaceae/*chemistry
Animals ; Colorectal Neoplasms/metabolism ; Erythrocytes/drug effects ; Female ; G2 Phase Cell Cycle Checkpoints/drug effects ; HCT116 Cells ; Hemolysis ; Humans ; Limonins/isolation & purification ; Limonins/therapeutic use ; Mice ; Plant Extracts/chemistry ; Plant Extracts/pharmacology
Czasopismo naukowe
Tytuł :
Colorectal cancer cell-derived extracellular vesicles transfer miR-221-3p to promote endothelial cell angiogenesis via targeting suppressor of cytokine signaling 3.
Autorzy :
Dokhanchi M; Department of Biology, Faculty of Sciences, Islamic Azad University, Tehran, Iran.
Pakravan K; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Zareian S; Department of Biology, Faculty of Sciences, Islamic Azad University, Tehran, Iran.
Hussen BM; Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Iraq.
Farid M; Department of Biology, Faculty of Sciences, Islamic Azad University, Tehran, Iran.
Razmara E; Department of Medical Genetics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Mossahebi-Mohammadi M; School of Pharmaceutical Sciences and International Collaborative Center on Growth Factor Research, Wenzhou Medical University, Wenzhou, China.
Cho WC; Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong. Electronic address: .
Babashah S; Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119937. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Colorectal Neoplasms/*blood supply
Colorectal Neoplasms/*pathology
MicroRNAs/*metabolism
Neovascularization, Pathologic/*metabolism
Suppressor of Cytokine Signaling 3 Protein/*metabolism
Biomarkers, Tumor/blood ; Cytokines/metabolism ; Extracellular Vesicles/metabolism ; HCT116 Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; Lymphatic Metastasis ; MicroRNAs/blood ; Neovascularization, Pathologic/genetics ; STAT3 Transcription Factor/metabolism ; Suppressor of Cytokine Signaling 3 Protein/genetics
Czasopismo naukowe
Tytuł :
Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer.
Autorzy :
Mochizuki Y; Department of Cell Proliferation, ART, Graduate School of Medicine, Tohoku University, Sendai, Japan.; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Funayama R; Department of Cell Proliferation, ART, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Shirota M; Division of Interdisciplinary Medical Science, ART, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Kikukawa Y; Department of Cell Proliferation, ART, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Ohira M; Department of Cell Proliferation, ART, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Karasawa H; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Kobayashi M; Department of Cell Proliferation, ART, Graduate School of Medicine, Tohoku University, Sendai, Japan.; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Ohnuma S; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Unno M; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Nakayama K; Department of Cell Proliferation, ART, Graduate School of Medicine, Tohoku University, Sendai, Japan.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Nov 15; Vol. 149 (10), pp. 1787-1800. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
Colorectal Neoplasms/*genetics
Exons/*genetics
Heterogeneous-Nuclear Ribonucleoproteins/*genetics
Polypyrimidine Tract-Binding Protein/*genetics
RNA Splicing Factors/*genetics
Repressor Proteins/*genetics
Cell Line, Tumor ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Gene Ontology ; HCT116 Cells ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Humans ; Immunoblotting ; Neoplasm Metastasis ; Polypyrimidine Tract-Binding Protein/metabolism ; Protein Binding ; RNA Precursors/genetics ; RNA Precursors/metabolism ; RNA Splicing Factors/metabolism ; Repressor Proteins/metabolism ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects.
Autorzy :
Xu S; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Guo A; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Chen NN; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Dai W; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Yang HA; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Xie W; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wang M; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
You QD; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
Xu XL; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113604. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article
MeSH Terms :
Alkynes/*therapeutic use
Anti-Inflammatory Agents/*therapeutic use
Benzamides/*therapeutic use
Colitis, Ulcerative/*drug therapy
Membrane Glycoproteins/*antagonists & inhibitors
Alkynes/chemical synthesis ; Alkynes/metabolism ; Alkynes/pharmacokinetics ; Animals ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/pharmacokinetics ; Benzamides/chemical synthesis ; Benzamides/metabolism ; Benzamides/pharmacokinetics ; Colitis, Ulcerative/pathology ; Colon/drug effects ; Colon/pathology ; HCT116 Cells ; Humans ; Male ; Membrane Glycoproteins/metabolism ; Mice, Inbred C57BL ; Microsomes, Liver/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Pharmacokinetics and Metabolites of 12 Bioactive Polymethoxyflavones in Rat Plasma.
Autorzy :
You Q; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.; Department of Pharmacy, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570100, People's Republic of China.
Li D; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.
Ding H; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.
Chen H; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.
Hu Y; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.
Liu Y; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610000, People's Republic of China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Nov 03; Vol. 69 (43), pp. 12705-12716. Date of Electronic Publication: 2021 Oct 26.
Typ publikacji :
Journal Article
MeSH Terms :
Flavones*/pharmacokinetics
A549 Cells ; Animals ; HCT116 Cells ; HeLa Cells ; Hep G2 Cells ; Humans ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Prognostic significance of high mobility group A2 (HMGA2) in pancreatic ductal adenocarcinoma: malignant functions of cytoplasmic HMGA2 expression.
Autorzy :
Gundlach JP; Department of General Surgery, Visceral-, Thoracic-, Transplantation- and Pediatric-Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller-Str. 3, Building C, 24105, Kiel, Germany.; Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller-Str. 3, Building U30, 24105, Kiel, Germany.
Hauser C; Department of General Surgery, Visceral-, Thoracic-, Transplantation- and Pediatric-Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller-Str. 3, Building C, 24105, Kiel, Germany.; Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller-Str. 3, Building U30, 24105, Kiel, Germany.
Schlegel FM; Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller-Str. 3, Building U30, 24105, Kiel, Germany.
Willms A; Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller-Str. 3, Building U30, 24105, Kiel, Germany.
Halske C; Department of Pathology, UKSH, Campus Kiel, Arnold-Heller-Str. 3, Building U33, 24105, Kiel, Germany.
Röder C; Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller-Str. 3, Building U30, 24105, Kiel, Germany.
Krüger S; Department of Pathology, UKSH, Campus Kiel, Arnold-Heller-Str. 3, Building U33, 24105, Kiel, Germany.
Röcken C; Department of Pathology, UKSH, Campus Kiel, Arnold-Heller-Str. 3, Building U33, 24105, Kiel, Germany.
Becker T; Department of General Surgery, Visceral-, Thoracic-, Transplantation- and Pediatric-Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller-Str. 3, Building C, 24105, Kiel, Germany.
Kalthoff H; Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller-Str. 3, Building U30, 24105, Kiel, Germany.
Trauzold A; Department of General Surgery, Visceral-, Thoracic-, Transplantation- and Pediatric-Surgery, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller-Str. 3, Building C, 24105, Kiel, Germany. .; Institute for Experimental Cancer Research, University of Kiel, Arnold-Heller-Str. 3, Building U30, 24105, Kiel, Germany. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Nov; Vol. 147 (11), pp. 3313-3324. Date of Electronic Publication: 2021 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Pancreatic Ductal/*metabolism
HMGA2 Protein/*biosynthesis
Pancreatic Neoplasms/*metabolism
Aged ; Aged, 80 and over ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Colonic Neoplasms/metabolism ; Cytoplasm/metabolism ; Female ; HCT116 Cells ; Humans ; Male ; Middle Aged ; Prognosis
Czasopismo naukowe
Tytuł :
Disruption of desmosome function leads to increased centrosome clustering in 14-3-3γ-knockout cells with supernumerary centrosomes.
Autorzy :
Tilwani S; Cell and Tumor Biology, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India.; Homi Bhabha National Institute, Training School Complex, Mumbai, India.
Gandhi K; Cell and Tumor Biology, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India.
Narayan S; Department of Chemical Sciences, TIFR, Mumbai, India.
Ainavarapu SRK; Department of Chemical Sciences, TIFR, Mumbai, India.
Dalal SN; Cell and Tumor Biology, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India.; Homi Bhabha National Institute, Training School Complex, Mumbai, India.
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Źródło :
FEBS letters [FEBS Lett] 2021 Nov; Vol. 595 (21), pp. 2675-2690. Date of Electronic Publication: 2021 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
14-3-3 Proteins*
Centrosome*
Desmosomes*
Mitosis*
HCT116 Cells ; Humans ; Spindle Apparatus
Czasopismo naukowe
Tytuł :
BZD9L1 sirtuin inhibitor: Identification of key molecular targets and their biological functions in HCT 116 colorectal cancer cells.
Autorzy :
Tan YJ; Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang 11800, Malaysia; Curtin Medical School, Curtin Health Innovation Research Institute (CHIRI) and Curtin Institute for Computation, Curtin University, GPO Box U1987, Perth, WA 6845, Australia.
Lee YT; Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang 11800, Malaysia.
Mancera RL; Curtin Medical School, Curtin Health Innovation Research Institute (CHIRI) and Curtin Institute for Computation, Curtin University, GPO Box U1987, Perth, WA 6845, Australia. Electronic address: .
Oon CE; Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang 11800, Malaysia. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 01; Vol. 284, pp. 119747. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Benzimidazoles/*pharmacology
Colorectal Neoplasms/*pathology
Sirtuins/*metabolism
Apoptosis/drug effects ; Apoptosis/genetics ; Cell Adhesion/drug effects ; Cell Adhesion/genetics ; Cell Polarity/drug effects ; Cell Polarity/genetics ; Colorectal Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Ontology ; HCT116 Cells ; Humans ; Neurites/drug effects ; Neurites/metabolism ; Protein Interaction Maps/drug effects ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/pathology
Czasopismo naukowe
Tytuł :
SLAMF7 and TREM1 Mediate Immunogenic Cell Death in Colorectal Cancer Cells: Focus on Microsatellite Stability.
Autorzy :
Roh SA; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
Kwon YH; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
Lee JL; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.; Department of Surgery, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kim SK; Medical Genomics Research Center, Korea Research Institute of Bioscience & Biotechnology, Daejeon, Republic of Korea.
Kim JC; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea; .; Department of Surgery, University of Ulsan College of Medicine, Seoul, Republic of Korea.
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Źródło :
Anticancer research [Anticancer Res] 2021 Nov; Vol. 41 (11), pp. 5431-5444.
Typ publikacji :
Journal Article
MeSH Terms :
Cytotoxicity, Immunologic*
Microsatellite Instability*
Colorectal Neoplasms/*metabolism
Signaling Lymphocytic Activation Molecule Family/*metabolism
Triggering Receptor Expressed on Myeloid Cells-1/*metabolism
Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apoptosis ; Cell Movement ; Cell Proliferation ; Coculture Techniques ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; HMGB1 Protein/genetics ; HMGB1 Protein/metabolism ; HT29 Cells ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Neoplasm Invasiveness ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/metabolism ; Signal Transduction ; Signaling Lymphocytic Activation Molecule Family/genetics ; THP-1 Cells ; Triggering Receptor Expressed on Myeloid Cells-1/antagonists & inhibitors ; Triggering Receptor Expressed on Myeloid Cells-1/genetics
Czasopismo naukowe
Tytuł :
In vitro antitubercular, anticancer activities and IL-10 expression in HCT-116 cells of Tinospora sinensis (Lour.) Merr. leaves extract.
Autorzy :
Badavenkatappa SG; Faculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University Anantapur (JNTUA), Anantapur, India.
Peraman R; RERDS-Centre for Pharmaceutical Research, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Anantapur, India.
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Źródło :
Natural product research [Nat Prod Res] 2021 Nov; Vol. 35 (22), pp. 4669-4674. Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Tinospora*
HCT116 Cells ; HeLa Cells ; Humans ; Interleukin-10 ; Plant Extracts/pharmacology
Czasopismo naukowe
Tytuł :
DOC-2/DAB2 interactive protein destabilizes c-Myc to impair the growth and self-renewal of colon tumor-repopulating cells.
Autorzy :
Li H; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Zhou Y; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Wang M; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Wang H; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Zhang Y; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Peng R; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Zhang R; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Zhang M; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Zhang M; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Qiu P; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Liu L; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Zhao Q; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
Liu J; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Nov; Vol. 112 (11), pp. 4593-4603. Date of Electronic Publication: 2021 Sep 12.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium-Binding Proteins/*metabolism
Colonic Neoplasms/*pathology
Neoplastic Stem Cells/*physiology
Nerve Tissue Proteins/*metabolism
Proto-Oncogene Proteins c-myc/*metabolism
ras GTPase-Activating Proteins/*metabolism
Animals ; Cell Proliferation ; Cell Self Renewal/physiology ; Colonic Neoplasms/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; HCT116 Cells ; HT29 Cells ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplastic Stem Cells/pathology ; Phenotype ; Phosphorylation ; Prognosis ; Protein Phosphatase 2/metabolism ; Spheroids, Cellular/physiology
Czasopismo naukowe
Tytuł :
C644-0303, a small-molecule inhibitor of the Wnt/β-catenin pathway, suppresses colorectal cancer growth.
Autorzy :
Yan Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Zhang Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Li M; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Zhang Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Zhang X; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Zhang X; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Xu Y; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Wei W; School of Life Science, Lanzhou University, Lanzhou, China.
Wang J; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Xu X; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Song Q; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
Zhao C; School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.; Innovation Platform of Marine Drug Screening & Evaluation, Qingdao Pilot National Laboratory for Marine Science and Technology, Qingdao, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Nov; Vol. 112 (11), pp. 4722-4735. Date of Electronic Publication: 2021 Sep 12.
Typ publikacji :
Journal Article
MeSH Terms :
Adenomatous Polyposis Coli/*drug therapy
Antineoplastic Agents/*therapeutic use
Colorectal Neoplasms/*drug therapy
Wnt Signaling Pathway/*drug effects
Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/pathology ; Animals ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Drug Discovery ; Female ; HCT116 Cells ; HT29 Cells ; Humans ; Luciferases ; MCF-7 Cells ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Targeted Therapy/methods ; Spheroids, Cellular/drug effects ; TCF Transcription Factors ; Transcription Factors/antagonists & inhibitors ; Xenograft Model Antitumor Assays ; beta Catenin/genetics
Czasopismo naukowe
Tytuł :
Zinc Inhibits Cadherin 1 Expression Induced by 1α,25-Dihydroxyvitamin D 3 in Colon Cancer Cells.
Autorzy :
Ishizawa M; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan.
Hirayu A; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan.; Department of Applied Biological Science, Nihon University College of Bioresource Sciences, Kanagawa, Japan.
Makishima M; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan; .
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Źródło :
Anticancer research [Anticancer Res] 2021 Nov; Vol. 41 (11), pp. 5453-5459.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, CD/*metabolism
Cadherins/*metabolism
Calcitriol/*pharmacology
Chlorides/*pharmacology
Colonic Neoplasms/*metabolism
Receptors, Calcitriol/*agonists
Zinc Compounds/*pharmacology
Antigens, CD/genetics ; Cadherins/genetics ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; Metallothionein/genetics ; Metallothionein/metabolism ; Receptors, Calcitriol/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response.
Autorzy :
Liu Y; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Qin C; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Rao Y; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Ngo C; Department of Chemistry, Dornsife College of Arts, Letters, and Sciences, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Feng JJ; Department of Chemistry, Dornsife College of Arts, Letters, and Sciences, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Zhao J; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.; Florida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, Florida, USA.
Zhang S; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Wang TY; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Carriere J; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Savas AC; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Zarinfar M; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Rice S; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Yang H; Molecular and Computational Biology Section, University of Southern California, Los Angeles, California, USA.
Yuan W; Department of Molecular Microbiology and Immunology, Keck School of Medicine, Los Angeles, California, USA.
Camarero JA; Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Yu J; Department of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA.
Chen XS; Molecular and Computational Biology Section, University of Southern California, Los Angeles, California, USA.
Zhang C; Department of Chemistry, Dornsife College of Arts, Letters, and Sciences, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
Feng P; Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern Californiagrid.42505.36, Los Angeles, California, USA.
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Źródło :
MBio [mBio] 2021 Oct 26; Vol. 12 (5), pp. e0233521. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Coronavirus 3C Proteases/*metabolism
DEAD Box Protein 58/*metabolism
Receptors, Immunologic/*metabolism
SARS-CoV-2/*immunology
SARS-CoV-2/*pathogenicity
A549 Cells ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Caco-2 Cells ; Coronavirus 3C Proteases/genetics ; DEAD Box Protein 58/genetics ; Enzyme-Linked Immunosorbent Assay ; HCT116 Cells ; HEK293 Cells ; Humans ; Immunity, Innate/genetics ; Immunity, Innate/physiology ; Immunoblotting ; Interferon Type I/metabolism ; Mice ; Receptors, Immunologic/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; Signal Transduction/physiology ; Ubiquitination ; Virus Replication/genetics ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
The Brazilian octocoral Phyllogorgia dilatata as a source of cytotoxic compounds.
Autorzy :
Fagundes TSF; Programa de Pós-Graduação em Química, Universidade Federal Fluminense, Instituto de Química, Outeiro de São João Batista, s/n, 24020-141 Niterói, RJ, Brazil.
Macedo AL; Programa de Pós-Graduação em Química, Universidade Federal Fluminense, Instituto de Química, Outeiro de São João Batista, s/n, 24020-141 Niterói, RJ, Brazil.; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal de Mato Grosso do Sul, Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Rua Ufms, 12, Pioneiros, 79070-900 Campo Grande, MS, Brazil.
Rigato DB; Universidade Federal de São Paulo, Instituto do Mar, Rua Carvalho de Mendonça, 144, Encruzilhada, 11070-100 Santos, SP, Brazil.
Amaral BSD; Universidade Federal de São Carlos, Departamento de Química, Rodovia Washington Luis, s/n, km 235, 13565-905 São Carlos, SP, Brazil.; Instituto Federal de Educação, Ciência e Tecnologia de São Paulo, Campus Pirituba, Av. Mutinga, 951, 05110-000 São Paulo, SP, Brazil.
Jimenez PC; Universidade Federal de São Carlos, Departamento de Química, Rodovia Washington Luis, s/n, km 235, 13565-905 São Carlos, SP, Brazil.
Costa-Lotufo LV; Universidade de São Paulo, Instituto de Ciências Biomédicas, Rua Pio XI, 1500, Alto da Lapa, 05468-901 São Paulo, SP, Brazil.
Pereira RFA; Programa de Pós-Graduação em Microbiologia e Parasitologia Aplicadas, Universidade Federal Fluminense, Departamento de Ciências Básicas, Rua Dr. Mario Vianna, 523, Santa Rosa, 24241-000 Niterói, RJ, Brazil.
Aguiar-Alves F; Programa de Pós-Graduação em Microbiologia e Parasitologia Aplicadas, Universidade Federal Fluminense, Departamento de Ciências Básicas, Rua Dr. Mario Vianna, 523, Santa Rosa, 24241-000 Niterói, RJ, Brazil.
Soares AR; Universidade Federal do Rio de Janeiro, Instituto de Biodiversidade e Sustentabilidade, Av. São José Barreto, 764, 27965-045 Macaé, RJ, Brazil.
Vasconcelos TRA; Programa de Pós-Graduação em Química, Universidade Federal Fluminense, Instituto de Química, Outeiro de São João Batista, s/n, 24020-141 Niterói, RJ, Brazil.
Cass QB; Universidade Federal de São Carlos, Departamento de Química, Rodovia Washington Luis, s/n, km 235, 13565-905 São Carlos, SP, Brazil.
Valverde AL; Programa de Pós-Graduação em Química, Universidade Federal Fluminense, Instituto de Química, Outeiro de São João Batista, s/n, 24020-141 Niterói, RJ, Brazil.
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Źródło :
Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2021 Oct 22; Vol. 93 (4), pp. e20200686. Date of Electronic Publication: 2021 Oct 22 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Anthozoa*/chemistry
Antineoplastic Agents*/pharmacology
Biological Products/*pharmacology
Animals ; HCT116 Cells ; Humans ; MCF-7 Cells
Czasopismo naukowe

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