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Tytuł :
SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining.
Autorzy :
Akimova E; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Cancer Cluster Salzburg, 5020 Salzburg, Austria.; Department of Biosciences, Paris Lodron University of Salzburg, 5020 Salzburg, Austria.
Gassner FJ; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Cancer Cluster Salzburg, 5020 Salzburg, Austria.
Schubert M; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Cancer Cluster Salzburg, 5020 Salzburg, Austria.
Rebhandl S; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Cancer Cluster Salzburg, 5020 Salzburg, Austria.
Arzt C; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Cancer Cluster Salzburg, 5020 Salzburg, Austria.
Rauscher S; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Cancer Cluster Salzburg, 5020 Salzburg, Austria.; Department of Biosciences, Paris Lodron University of Salzburg, 5020 Salzburg, Austria.
Tober V; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Cancer Cluster Salzburg, 5020 Salzburg, Austria.; Department of Biosciences, Paris Lodron University of Salzburg, 5020 Salzburg, Austria.
Zaborsky N; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Cancer Cluster Salzburg, 5020 Salzburg, Austria.
Greil R; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Cancer Cluster Salzburg, 5020 Salzburg, Austria.
Geisberger R; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria.; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR); Cancer Cluster Salzburg, 5020 Salzburg, Austria.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2598-2608.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA End-Joining Repair*
SAM Domain and HD Domain-Containing Protein 1/*physiology
CRISPR-Associated Protein 9/metabolism ; Chromosome Breakage ; Deoxyribonucleotides/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; SAM Domain and HD Domain-Containing Protein 1/metabolism
Czasopismo naukowe
Tytuł :
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Autorzy :
Yu CH; Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, TX, USA.
Bhattacharya A; Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, TX, USA.
Persaud M; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Taylor AB; Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, TX, USA.
Wang Z; Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, TX, USA.
Bulnes-Ramos A; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Xu J; Department of Pediatrics, Emory School of Medicine, Atlanta, GA, USA.
Selyutina A; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Martinez-Lopez A; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Cano K; Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, TX, USA.
Demeler B; Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, Canada.; Department of Chemistry and Biochemistry, University of Montana, Missoula, MT, USA.
Kim B; Department of Pediatrics, Emory School of Medicine, Atlanta, GA, USA.
Hardies SC; Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, TX, USA.
Diaz-Griffero F; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA. .
Ivanov DN; Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 02; Vol. 12 (1), pp. 731. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Nucleotides/*metabolism
SAM Domain and HD Domain-Containing Protein 1/*metabolism
Humans ; Immunity, Innate/genetics ; Immunity, Innate/physiology ; Mutation/genetics ; Oxidoreductases Acting on CH-CH Group Donors/genetics ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; SAM Domain and HD Domain-Containing Protein 1/genetics
Czasopismo naukowe
Tytuł :
TRAF6 and TAK1 Contribute to SAMHD1-Mediated Negative Regulation of NF-κB Signaling.
Autorzy :
Espada CE; Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
St Gelais C; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
Bonifati S; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
Maksimova VV; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
Cahill MP; Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Kim SH; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.
Wu L; Department of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA .
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Źródło :
Journal of virology [J Virol] 2021 Jan 13; Vol. 95 (3). Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
HIV Infections/*immunology
Immunity, Innate/*immunology
Intracellular Signaling Peptides and Proteins/*metabolism
MAP Kinase Kinase Kinases/*metabolism
NF-kappa B/*metabolism
SAM Domain and HD Domain-Containing Protein 1/*metabolism
HEK293 Cells ; HIV Infections/metabolism ; HIV Infections/virology ; HIV-1/physiology ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; MAP Kinase Kinase Kinases/genetics ; NF-kappa B/genetics ; SAM Domain and HD Domain-Containing Protein 1/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
SAMHD1 expression is associated with low immune activation but not correlated with HIV‑1 DNA levels in CD4+ T cells of patients with HIV‑1.
Autorzy :
Li J; Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
Gao C; Laboratory of Biochemistry and Biomaterials, Department of Materials, College of Chemical and Material Engineering, Quzhou University, Quzhou, Zhejiang 324000, P.R. China.
Huang S; Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
Jin L; Department of Childhood Infectious Disease, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
Jin C; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2020 Aug; Vol. 22 (2), pp. 879-885. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
CD4-Positive T-Lymphocytes/*chemistry
CD4-Positive T-Lymphocytes/*immunology
DNA, Viral/*blood
HIV Infections/*immunology
HIV-1/*chemistry
SAM Domain and HD Domain-Containing Protein 1/*blood
SAM Domain and HD Domain-Containing Protein 1/*immunology
Adult ; Anti-Retroviral Agents/therapeutic use ; Female ; Gene Expression Regulation, Enzymologic ; HIV Infections/blood ; HIV Infections/drug therapy ; HIV Infections/metabolism ; HIV-1/genetics ; Humans ; Interferon-alpha/blood ; Leukocytes, Mononuclear/chemistry ; Male ; Middle Aged ; RNA, Viral/blood ; SAM Domain and HD Domain-Containing Protein 1/genetics ; Viral Load
Czasopismo naukowe
Tytuł :
Induction of Samhd1 by interferon gamma and lipopolysaccharide in murine macrophages requires IRF1.
Autorzy :
Valverde-Estrella L; Macrophage Biology Group, Department of Cellular Biology, Physiology and Immunology, Universitat de Barcelona, Barcelona, Spain.
López-Serrat M; Macrophage Biology Group, Department of Cellular Biology, Physiology and Immunology, Universitat de Barcelona, Barcelona, Spain.
Sánchez-Sànchez G; Macrophage Biology Group, Department of Cellular Biology, Physiology and Immunology, Universitat de Barcelona, Barcelona, Spain.
Vico T; Macrophage Biology Group, Department of Cellular Biology, Physiology and Immunology, Universitat de Barcelona, Barcelona, Spain.
Lloberas J; Macrophage Biology Group, Department of Cellular Biology, Physiology and Immunology, Universitat de Barcelona, Barcelona, Spain.
Celada A; Macrophage Biology Group, Department of Cellular Biology, Physiology and Immunology, Universitat de Barcelona, Barcelona, Spain.
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Źródło :
European journal of immunology [Eur J Immunol] 2020 Sep; Vol. 50 (9), pp. 1321-1334. Date of Electronic Publication: 2020 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation/*immunology
Interferon Regulatory Factor-1/*metabolism
Interferon-gamma/*immunology
Macrophages/*immunology
SAM Domain and HD Domain-Containing Protein 1/*metabolism
Animals ; Interferon Regulatory Factor-1/immunology ; Interferon-gamma/pharmacology ; Lipopolysaccharides/immunology ; Lipopolysaccharides/pharmacology ; Macrophages/metabolism ; Mice ; Mice, Inbred BALB C ; SAM Domain and HD Domain-Containing Protein 1/immunology
Czasopismo naukowe
Tytuł :
Fingolimod inhibits multiple stages of the HIV-1 life cycle.
Autorzy :
Resop RS; Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, D.C., United States of America.
Fromentin R; Centre de recherche du CHUM and Department of microbiology, infectiology and immunology, Université de Montréal, Montreal, Canada.
Newman D; Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, D.C., United States of America.
Rigsby H; Centre de recherche du CHUM and Department of microbiology, infectiology and immunology, Université de Montréal, Montreal, Canada.
Dubrovsky L; Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, D.C., United States of America.
Bukrinsky M; Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, D.C., United States of America.
Chomont N; Centre de recherche du CHUM and Department of microbiology, infectiology and immunology, Université de Montréal, Montreal, Canada.
Bosque A; Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, D.C., United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Aug 13; Vol. 16 (8), pp. e1008679. Date of Electronic Publication: 2020 Aug 13 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Virus Replication*
Fingolimod Hydrochloride/*pharmacology
HIV Infections/*drug therapy
HIV-1/*growth & development
SAM Domain and HD Domain-Containing Protein 1/*antagonists & inhibitors
Sphingosine 1 Phosphate Receptor Modulators/*pharmacology
T-Lymphocytes/*immunology
HIV Infections/immunology ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/immunology ; Humans ; Lysophospholipids/metabolism ; Phosphorylation ; SAM Domain and HD Domain-Containing Protein 1/metabolism ; Signal Transduction ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; T-Lymphocytes/drug effects ; Virus Latency
Czasopismo naukowe
Tytuł :
SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.
Autorzy :
Husain A; Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Xu J; Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Fujii H; Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.; Combined Program on Microbiology and Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Nakata M; Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kobayashi M; Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Wang JY; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Rehwinkel J; Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Honjo T; Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Begum NA; Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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Źródło :
The EMBO journal [EMBO J] 2020 Aug 03; Vol. 39 (15), pp. e102931. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
Immunoglobulin Class Switching*
Deoxyribonucleotides/*metabolism
SAM Domain and HD Domain-Containing Protein 1/*metabolism
Cell Line ; Deoxyribonucleotides/genetics ; Humans ; SAM Domain and HD Domain-Containing Protein 1/genetics
Czasopismo naukowe
Tytuł :
Dysregulation of the mevalonate pathway during SARS-CoV-2 infection: An in silico study.
Autorzy :
Gomez Marti JL; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Pittsburgh VA Health System, Pittsburgh, Pennsylvania, USA.
Wells A; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Pittsburgh VA Health System, Pittsburgh, Pennsylvania, USA.; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.
Brufsky AM; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.; Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Apr; Vol. 93 (4), pp. 2396-2405. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*metabolism
Mevalonic Acid/*metabolism
SARS-CoV-2/*metabolism
A549 Cells ; Autophagy ; COVID-19/genetics ; COVID-19/immunology ; COVID-19/virology ; Computer Simulation ; Cytokines/immunology ; Cytokines/metabolism ; HMGB1 Protein/genetics ; HMGB1 Protein/metabolism ; Host-Pathogen Interactions ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/metabolism ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza A Virus, H3N2 Subtype/metabolism ; Influenza, Human/immunology ; Influenza, Human/metabolism ; SAM Domain and HD Domain-Containing Protein 1/genetics ; SAM Domain and HD Domain-Containing Protein 1/metabolism ; SARS-CoV-2/genetics ; Signal Transduction ; Transcriptome ; Virus Replication
Czasopismo naukowe
Tytuł :
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Autorzy :
Morris ER; Macromolecular Structure Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Caswell SJ; Macromolecular Structure Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; AstraZeneca, 50F49, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.
Kunzelmann S; Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Arnold LH; Macromolecular Structure Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.; Pelago Bioscience, Banvaktsvägen 20, 171 48, Solna, Sweden.
Purkiss AG; Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Kelly G; The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Taylor IA; Macromolecular Structure Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 23; Vol. 11 (1), pp. 3165. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nucleoside-Triphosphatase/*chemistry
SAM Domain and HD Domain-Containing Protein 1/*chemistry
Water/*chemistry
Autoimmune Diseases of the Nervous System/metabolism ; Catalytic Domain ; Crystallography, X-Ray ; HIV-1/genetics ; HIV-1/physiology ; Humans ; Hydrolysis ; Interferons ; Models, Molecular ; Mutation ; Nervous System Malformations/metabolism ; Polyphosphates ; Protein Conformation ; SAM Domain and HD Domain-Containing Protein 1/genetics ; Virus Replication/physiology
SCR Disease Name :
Aicardi-Goutieres syndrome
Czasopismo naukowe
Tytuł :
Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).
Autorzy :
Zhang Z; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
Zheng L; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
Yu Y; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
Wu J; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
Yang F; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
Xu Y; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
Guo Q; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
Wu X; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
Cao S; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
Cao L; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
Song X; College of Basic Medical Science, Institute of Translational Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China.
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Źródło :
International journal of oncology [Int J Oncol] 2020 Apr; Vol. 56 (4), pp. 879-888. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
DNA Repair*
Genomic Instability*
Homeostasis*
Mutation*
Neoplasms/*drug therapy
Nucleic Acid Precursors/*metabolism
SAM Domain and HD Domain-Containing Protein 1/*metabolism
DNA Replication ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; SAM Domain and HD Domain-Containing Protein 1/genetics
Czasopismo naukowe
Tytuł :
SAMHD1 Functions and Human Diseases.
Autorzy :
Coggins SA; Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30032, USA.
Mahboubi B; Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30032, USA.
Schinazi RF; Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30032, USA.
Kim B; Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30032, USA.; Center for Drug Discovery, Children's Healthcare of Atlanta, Atlanta, GA 30032, USA.
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Źródło :
Viruses [Viruses] 2020 Mar 31; Vol. 12 (4). Date of Electronic Publication: 2020 Mar 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
SAM Domain and HD Domain-Containing Protein 1/*physiology
Autoimmune Diseases of the Nervous System/genetics ; Autoimmune Diseases of the Nervous System/immunology ; DNA Repair ; Deoxyribonucleotides/metabolism ; Humans ; Immunity, Innate ; Mutation ; Neoplasms/genetics ; Neoplasms/metabolism ; Nervous System Malformations/genetics ; Nervous System Malformations/immunology ; Protein Domains ; Protein Processing, Post-Translational ; SAM Domain and HD Domain-Containing Protein 1/chemistry ; SAM Domain and HD Domain-Containing Protein 1/genetics ; SAM Domain and HD Domain-Containing Protein 1/metabolism ; Virus Diseases/immunology ; Virus Diseases/virology ; Virus Replication
SCR Disease Name :
Aicardi-Goutieres syndrome
Czasopismo naukowe
Tytuł :
The C-terminal domain of feline and bovine SAMHD1 proteins has a crucial role in lentiviral restriction.
Autorzy :
Wang C; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China; The First Hospital and Institute of Immunology, Jilin University, Changchun 130012, China.
Zhang K; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Meng L; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Zhang X; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Song Y; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Zhang Y; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Gai Y; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Zhang Y; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Yu B; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Wu J; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Wang S; Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, Jilin University, Changchun 130012, China.
Yu X; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Mar 27; Vol. 295 (13), pp. 4252-4264. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV/*genetics
Lentivirus/*genetics
Reverse Transcription/*genetics
SAM Domain and HD Domain-Containing Protein 1/*genetics
Animals ; Cats ; Cattle ; HEK293 Cells ; HIV/pathogenicity ; Host-Pathogen Interactions/genetics ; Humans ; Lentivirus/pathogenicity ; Myeloid Cells/virology ; Protein Domains/genetics ; SAM Domain and HD Domain-Containing Protein 1/chemistry ; T-Lymphocytes/virology ; Virus Replication/genetics
Czasopismo naukowe
Tytuł :
The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.
Autorzy :
Qin Z; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Bonifati S; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.
St Gelais C; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.
Li TW; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.
Kim SH; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.
Antonucci JM; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210.
Mahboubi B; Center for Drug Discovery, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322.
Yount JS; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio 43210.
Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520.
Kim B; Center for Drug Discovery, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322.
Wu L; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242; Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University, Columbus, Ohio 43210. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Feb 07; Vol. 295 (6), pp. 1575-1586. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Monocytes/*immunology
SAM Domain and HD Domain-Containing Protein 1/*immunology
Cell Nucleus/immunology ; Humans ; Respirovirus Infections/immunology ; SAM Domain and HD Domain-Containing Protein 1/analysis ; Sendai virus/immunology ; THP-1 Cells ; U937 Cells
Czasopismo naukowe
Tytuł :
SAMHD1-deficient fibroblasts from Aicardi-Goutières Syndrome patients can escape senescence and accumulate mutations.
Autorzy :
Franzolin E; Department of Biology, University of Padova, Padova, Italy.
Coletta S; Department of Biology, University of Padova, Padova, Italy.
Ferraro P; Department of Biology, University of Padova, Padova, Italy.
Pontarin G; Department of Biology, University of Padova, Padova, Italy.
D'Aronco G; Department of Biology, University of Padova, Padova, Italy.
Stevanoni M; Department of Biology, University of Padova, Padova, Italy.
Palumbo E; Department of Molecular Medicine, University of Padova, Padova, Italy.
Cagnin S; Department of Biology, University of Padova, Padova, Italy.; CRIBI Biotechnology Center, University of Padova, Padova, Italy.; CIR-Myo Myology Center, University of Padova, Padova, Italy.
Bertoldi L; Department of Biology, University of Padova, Padova, Italy.
Feltrin E; Department of Biology, University of Padova, Padova, Italy.
Valle G; Department of Biology, University of Padova, Padova, Italy.
Russo A; Department of Molecular Medicine, University of Padova, Padova, Italy.
Bianchi V; Department of Biology, University of Padova, Padova, Italy.
Rampazzo C; Department of Biology, University of Padova, Padova, Italy.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Jan; Vol. 34 (1), pp. 631-647. Date of Electronic Publication: 2019 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoimmune Diseases of the Nervous System/*genetics
Fibroblasts/*metabolism
Mutation/*genetics
Nervous System Malformations/*genetics
SAM Domain and HD Domain-Containing Protein 1/*deficiency
DNA Damage/genetics ; DNA Replication/genetics ; Humans ; Monomeric GTP-Binding Proteins/metabolism ; SAM Domain and HD Domain-Containing Protein 1/genetics
SCR Disease Name :
Aicardi-Goutieres syndrome
Czasopismo naukowe
Tytuł :
Expression and Relationship of SAMHD1 with Other Apoptotic and Autophagic Genes in Acute Myeloid Leukemia Patients.
Autorzy :
Jiang H; Hematology Department, Shengjing Hospital, China Medical University, Shenyang, China.
Li C; Hematology Department, Shengjing Hospital, China Medical University, Shenyang, China.
Liu Z; Hematology Department, Shengjing Hospital, China Medical University, Shenyang, China.
Shengjing Hospital
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Corporate Authors :
Hu
Źródło :
Acta haematologica [Acta Haematol] 2020; Vol. 143 (1), pp. 51-59. Date of Electronic Publication: 2019 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis Regulatory Proteins/*metabolism
Leukemia, Myeloid, Acute/*diagnosis
SAM Domain and HD Domain-Containing Protein 1/*metabolism
Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis Regulatory Proteins/genetics ; Down-Regulation ; Female ; Gene Expression ; Humans ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/metabolism ; Leukocytes/cytology ; Male ; Middle Aged ; Prognosis ; SAM Domain and HD Domain-Containing Protein 1/genetics ; Survival Rate ; X-Linked Inhibitor of Apoptosis Protein/genetics ; X-Linked Inhibitor of Apoptosis Protein/metabolism ; bcl-2 Homologous Antagonist-Killer Protein/genetics ; bcl-2 Homologous Antagonist-Killer Protein/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism ; bcl-X Protein/genetics ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1.
Autorzy :
Deutschmann J; Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Schneider A; Chair of Genetics, Department of Biology, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Gruska I; Laboratory of Molecular Pediatrics, Department of Pediatric Oncology, Hematology and Stem Cell Transplantation, Charité Universitätsmedizin, Berlin, Germany.
Vetter B; Laboratory of Molecular Pediatrics, Department of Pediatric Oncology, Hematology and Stem Cell Transplantation, Charité Universitätsmedizin, Berlin, Germany.
Thomas D; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, Frankfurt, Germany.
Kießling M; Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Wittmann S; Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Herrmann A; Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Schindler M; Institute for Medical Virology, University Hospital Tübingen, Tübingen, Germany.
Milbradt J; Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Ferreirós N; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, Frankfurt, Germany.; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Frankfurt, Germany.
Winkler TH; Chair of Genetics, Department of Biology, Nikolaus-Fiebiger-Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Wiebusch L; Laboratory of Molecular Pediatrics, Department of Pediatric Oncology, Hematology and Stem Cell Transplantation, Charité Universitätsmedizin, Berlin, Germany.
Gramberg T; Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. .
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Źródło :
Nature microbiology [Nat Microbiol] 2019 Dec; Vol. 4 (12), pp. 2273-2284. Date of Electronic Publication: 2019 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Muromegalovirus/*drug effects
Phosphotransferases/*metabolism
SAM Domain and HD Domain-Containing Protein 1/*antagonists & inhibitors
SAM Domain and HD Domain-Containing Protein 1/*metabolism
Animals ; Antiviral Agents/pharmacology ; Colony-Stimulating Factors/metabolism ; Disease Models, Animal ; HEK293 Cells ; Herpesviridae Infections/drug therapy ; Herpesviridae Infections/virology ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muromegalovirus/enzymology ; Muromegalovirus/growth & development ; NIH 3T3 Cells ; Phosphorylation ; Recombinant Proteins ; SAM Domain and HD Domain-Containing Protein 1/genetics ; Transcriptome ; Viral Proteins/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97.
Autorzy :
Businger R; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
Deutschmann J; Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Gruska I; Laboratory of Molecular Pediatrics, Department of Pediatrics, Division of Oncology and Hematology, Charité Universitätsmedizin, Berlin, Germany.
Milbradt J; Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Wiebusch L; Laboratory of Molecular Pediatrics, Department of Pediatrics, Division of Oncology and Hematology, Charité Universitätsmedizin, Berlin, Germany.
Gramberg T; Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Schindler M; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany. .
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Źródło :
Nature microbiology [Nat Microbiol] 2019 Dec; Vol. 4 (12), pp. 2260-2272. Date of Electronic Publication: 2019 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytomegalovirus/*metabolism
Cytomegalovirus Infections/*virology
Macrophages/*immunology
SAM Domain and HD Domain-Containing Protein 1/*metabolism
Viral Proteins/*metabolism
Cytomegalovirus/pathogenicity ; HEK293 Cells ; Humans ; Immunity, Innate ; Macrophages/virology ; Phosphorylation ; SAM Domain and HD Domain-Containing Protein 1/genetics ; SAM Domain and HD Domain-Containing Protein 1/pharmacology ; THP-1 Cells ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Interferon γ and α Have Differential Effects on SAMHD1, a Potent Antiviral Protein, in Feline Lymphocytes.
Autorzy :
Asadian P; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada. .
Bienzle D; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada. .
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Źródło :
Viruses [Viruses] 2019 Oct 09; Vol. 11 (10). Date of Electronic Publication: 2019 Oct 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*virology
Interferon-alpha/*pharmacology
Interferon-gamma/*pharmacology
SAM Domain and HD Domain-Containing Protein 1/*drug effects
Animals ; Antiviral Agents/metabolism ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/metabolism ; Cats ; Cell Line ; Gene Expression/drug effects ; Interleukin-2/metabolism ; Lentivirus/drug effects ; Lentivirus/growth & development ; Phosphorylation/drug effects ; SAM Domain and HD Domain-Containing Protein 1/genetics ; SAM Domain and HD Domain-Containing Protein 1/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial.
Autorzy :
Roider T; Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Wang X; Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Hüttl K; Department of Clinical Pathology, Robert-Bosch-Hospital, Stuttgart, Germany.
Müller-Tidow C; Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Klapper W; Department of Pathology, University of Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Rosenwald A; Institute of Pathology, University of Würzburg, Würzburg, Germany.
Stewart JP; Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK.
de Castro DG; Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK.
Dreger P; Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Hermine O; Hôpital Necker-Enfants Malades, Paris, France.
Kluin-Nelemans HC; Department of Hematology, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands.
Grabe N; Hamamatsu Tissue Imaging and Analysis Center (TIGA), Bioquant, University of Heidelberg, Heidelberg, Germany.
Dreyling M; Department of Medicine III, University Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Pott C; Second Medical Department, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Ott G; Department of Clinical Pathology, Robert-Bosch-Hospital, Stuttgart, Germany.
Hoster E; Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität Munich, Munich, Germany.
Dietrich S; Department of Medicine V, Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Jan 01; Vol. 148 (1), pp. 150-160. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Biomarkers, Tumor/*genetics
Drug Resistance, Neoplasm/*genetics
Lymphoma, B-Cell/*drug therapy
Lymphoma, Mantle-Cell/*drug therapy
SAM Domain and HD Domain-Containing Protein 1/*genetics
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cell Line, Tumor ; Cyclophosphamide/pharmacology ; Cyclophosphamide/therapeutic use ; Cytarabine/pharmacology ; Cytarabine/therapeutic use ; DNA Mutational Analysis ; Disease-Free Survival ; Dose-Response Relationship, Drug ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Drug Resistance, Neoplasm/drug effects ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Lymphoma, B-Cell/genetics ; Lymphoma, B-Cell/pathology ; Lymphoma, Mantle-Cell/genetics ; Lymphoma, Mantle-Cell/mortality ; Male ; Middle Aged ; Mutation ; Oxaliplatin/pharmacology ; Oxaliplatin/therapeutic use ; Prednisone/pharmacology ; Prednisone/therapeutic use ; Primary Cell Culture ; Rituximab/pharmacology ; Rituximab/therapeutic use ; Tissue Array Analysis ; Vidarabine/analogs & derivatives ; Vidarabine/pharmacology ; Vidarabine/therapeutic use ; Vincristine/pharmacology ; Vincristine/therapeutic use
Czasopismo naukowe

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