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Tytuł :
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia.
Autorzy :
Greinacher A; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Selleng K; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Palankar R; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Wesche J; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Handtke S; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Wolff M; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Aurich K; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Lalk M; Institute of Biochemistry, University of Greifswald, Greifswald, Germany.
Methling K; Institute of Biochemistry, University of Greifswald, Greifswald, Germany.
Völker U; Interfaculty Institute of Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.
Hentschker C; Interfaculty Institute of Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Michalik S; Interfaculty Institute of Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Steil L; Interfaculty Institute of Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Reder A; Interfaculty Institute of Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Schönborn L; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Beer M; Institute of Diagnostic Virology, Friedrich-Loeffler Institute, Greifswald-Insel Riems, Germany.
Franzke K; Institute of Infectious Diseases, Friedrich-Loeffler Institute, Greifswald-Insel Riems, Germany.
Büttner A; Institute of Forensic Medicine, Rostock University Medical Center, Rostock, Germany.
Fehse B; Research Department Cell & Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.
Stavrou EX; Department of Medicine, Hematology and Oncology Division, CWRU School of Medicine, Cleveland, OH.; Department of Medicine, Section of Hematology-Oncology, Louis Stokes Veterans Administration Medical Center, Cleveland, OH.
Rangaswamy C; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Mailer RK; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Englert H; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Frye M; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Thiele T; Institute of Immunology and Transfusion Medicine, Department of Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Kochanek S; Department of Gene Therapy, Ulm University, Ulm, Germany.
Krutzke L; Department of Gene Therapy, Ulm University, Ulm, Germany.
Siegerist F; Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Endlich N; Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.; NIPOKA GmbH, Greifswald, Germany.
Warkentin TE; Department of Pathology and Molecular Medicine, and.; Department of Medicine, McMaster University, Hamilton, ON, Canada; and.
Renné T; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.; Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, Mainz, Germany.
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Źródło :
Blood [Blood] 2021 Dec 02; Vol. 138 (22), pp. 2256-2268.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Contamination*
SARS-CoV-2*
Antigen-Antibody Complex/*immunology
Autoantibodies/*immunology
COVID-19/*prevention & control
Capsid Proteins/*adverse effects
ChAdOx1 nCoV-19/*adverse effects
Genetic Vectors/*adverse effects
HEK293 Cells/*immunology
Immunoglobulin G/*immunology
Platelet Factor 4/*immunology
Purpura, Thrombocytopenic, Idiopathic/*etiology
Spike Glycoprotein, Coronavirus/*adverse effects
Adenoviridae/immunology ; Animals ; Antigen-Antibody Complex/ultrastructure ; Autoantibodies/biosynthesis ; Capillary Leak Syndrome/etiology ; Capsid Proteins/immunology ; Cell Line, Transformed ; ChAdOx1 nCoV-19/chemistry ; ChAdOx1 nCoV-19/immunology ; ChAdOx1 nCoV-19/toxicity ; Dynamic Light Scattering ; Epitopes/chemistry ; Epitopes/immunology ; Extracellular Traps/immunology ; Extravasation of Diagnostic and Therapeutic Materials/etiology ; Genetic Vectors/immunology ; HEK293 Cells/chemistry ; Humans ; Imaging, Three-Dimensional ; Immunoglobulin G/biosynthesis ; Inflammation ; Mice ; Microscopy/methods ; Platelet Activation ; Proteomics ; Purpura, Thrombocytopenic, Idiopathic/blood ; Purpura, Thrombocytopenic, Idiopathic/immunology ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Sinus Thrombosis, Intracranial/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Virus Cultivation
Czasopismo naukowe
Tytuł :
Oleic acid blocks the calcium-activated chloride channel TMEM16A/ANO1.
Autorzy :
Leon-Aparicio D; Physics Institute, Universidad Autónoma de San Luis Potosí, Ave. Dr. Manuel Nava #6, San Luis Potosí SLP 78290, Mexico.
Sánchez-Solano A; Physics Institute, Universidad Autónoma de San Luis Potosí, Ave. Dr. Manuel Nava #6, San Luis Potosí SLP 78290, Mexico.
Arreola J; Physics Institute, Universidad Autónoma de San Luis Potosí, Ave. Dr. Manuel Nava #6, San Luis Potosí SLP 78290, Mexico. Electronic address: .
Perez-Cornejo P; Department of Physiology and Biophysics, Universidad Autónoma de San Luis Potosí School of Medicine, Ave. V. Carranza 2405, San Luis Potosí SLP 78210, Mexico.. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2022 May; Vol. 1867 (5), pp. 159134. Date of Electronic Publication: 2022 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chloride Channels*/chemistry
Chloride Channels*/genetics
Chloride Channels*/metabolism
Oleic Acid*/pharmacology
Anions/metabolism ; Anoctamin-1/genetics ; Anoctamin-1/metabolism ; Calcium/metabolism ; HEK293 Cells ; Humans ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism
Czasopismo naukowe
Tytuł :
Transduction of HEK293 Cells with BacMam Baculovirus Is an Efficient System for the Production of HIV-1 Virus-like Particles.
Autorzy :
Puente-Massaguer E; Department of Chemical, Biological and Environmental Engineering, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.
Cajamarca-Berrezueta B; Department of Chemical, Biological and Environmental Engineering, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.
Volart A; Department of Chemical, Biological and Environmental Engineering, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.
González-Domínguez I; Department of Chemical, Biological and Environmental Engineering, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.
Gòdia F; Department of Chemical, Biological and Environmental Engineering, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.
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Źródło :
Viruses [Viruses] 2022 Mar 18; Vol. 14 (3). Date of Electronic Publication: 2022 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV-1*/genetics
Viruses, Unclassified*/genetics
Animals ; Baculoviridae/genetics ; DNA ; HEK293 Cells ; Humans ; Mammals ; Virion/genetics
Czasopismo naukowe
Tytuł :
Micrometric DNA/PEI polyplexes correlate with higher transient gene expression yields in HEK 293 cells.
Autorzy :
González-Domínguez I; Grup d'Enginyeria Cel·lular i Bioprocessos. Departament d'Enginyeria Química Biològica i Ambiental, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain. Electronic address: .
Puente-Massaguer E; Grup d'Enginyeria Cel·lular i Bioprocessos. Departament d'Enginyeria Química Biològica i Ambiental, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain.
Lavado-García J; Grup d'Enginyeria Cel·lular i Bioprocessos. Departament d'Enginyeria Química Biològica i Ambiental, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain.
Cervera L; Grup d'Enginyeria Cel·lular i Bioprocessos. Departament d'Enginyeria Química Biològica i Ambiental, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain.
Gòdia F; Grup d'Enginyeria Cel·lular i Bioprocessos. Departament d'Enginyeria Química Biològica i Ambiental, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain.
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Źródło :
New biotechnology [N Biotechnol] 2022 May 25; Vol. 68, pp. 87-96. Date of Electronic Publication: 2022 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
DNA*/genetics
Polyethyleneimine*/chemistry
Animals ; Gene Expression ; Gene Transfer Techniques ; HEK293 Cells ; Humans ; Transfection
Czasopismo naukowe
Tytuł :
Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle.
Autorzy :
Niu L; Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, PR China.
Wang J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, PR China.
Shen F; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, PR China.
Gao J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, PR China.
Jiang M; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, PR China.
Bai G; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, PR China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2022 May 23; Vol. 290, pp. 115105. Date of Electronic Publication: 2022 Feb 11.
Typ publikacji :
Journal Article
MeSH Terms :
Biphenyl Compounds/*pharmacology
Calcium Signaling/*drug effects
Intestines/*drug effects
Lignans/*pharmacology
Muscle, Smooth/*drug effects
Animals ; HEK293 Cells ; Humans ; Male ; Medicine, Chinese Traditional ; Muscle Contraction/drug effects ; Myocytes, Smooth Muscle/drug effects ; Rats ; Rats, Sprague-Dawley ; TRPC Cation Channels/drug effects ; TRPV Cation Channels/drug effects
Czasopismo naukowe
Tytuł :
New αIIbβ3 variants in 28 Turkish Glanzmann patients; structural hypothesis for complex activation by residues variations in I-EGF domains.
Autorzy :
Koker MY; Faculty of Medicine, Department of Immunology, Erciyes University, Kayseri, Turkey.
Sarper N; Faculty of Medicine, Department of Pediatrics, Division of Pediatric Hematology, Kocaeli University, Kocaeli, Turkey.
Albayrak C; Faculty of Medicine, Department of Pediatrics, Division of Pediatric Hematology and Oncology, Ondokuz Mayis University, Samsun, Turkey.
Zulfikar B; Oncology Institute, Department of Pediatric Hematology/Oncology, Istanbul University, İstanbul, Turkey.
Zengin E; Faculty of Medicine, Department of Pediatrics, Division of Pediatric Hematology, Kocaeli University, Kocaeli, Turkey.
Saraymen B; Nanotechnology Research and Application Center, Erciyes University, Kayseri, Turkey.
Albayrak D; Faculty of Medicine, Department of Pediatrics, Division of Pediatric Hematology and Oncology, Ondokuz Mayis University, Samsun, Turkey.
Koc B; Oncology Institute, Department of Pediatric Hematology/Oncology, Istanbul University, İstanbul, Turkey.
Avcilar H; Faculty of Medicine, Department of Immunology, Erciyes University, Kayseri, Turkey.
Karakükcü M; Faculty of Medicine, Department of Pediatrics, Division of Pediatric Hematology, Erciyes University, Kayseri, Turkey.
Chenet C; Département d'Immunologie Plaquettaire, Institut National De La Transfusion Sanguine (INTS), Paris, France.; Centre National de Référence en Hémobiologie Périnatale (CNRHP), Site St Antoine, DMU Biologie et Génomique Médicales, AP-HP, Sorbonne Université PARIS, FRANCE.
Bianchi F; Département d'Immunologie Plaquettaire, Institut National De La Transfusion Sanguine (INTS), Paris, France.; Centre National de Référence en Hémobiologie Périnatale (CNRHP), Site St Antoine, DMU Biologie et Génomique Médicales, AP-HP, Sorbonne Université PARIS, FRANCE.
de Brevern AG; Biologie Intégrée du Globule Rouge UMR_S1134, Inserm, DSIMB, Univ. Paris, Univ. De La Réunion, Univ. Des Antilles, Paris, France.; Institut National de la Transfusion Sanguine (INTS), Paris, France.; Laboratoire d'Excellence GR-Ex, Paris, France.
Petermann R; Département d'Immunologie Plaquettaire, Institut National De La Transfusion Sanguine (INTS), Paris, France.; Centre National de Référence en Hémobiologie Périnatale (CNRHP), Site St Antoine, DMU Biologie et Génomique Médicales, AP-HP, Sorbonne Université PARIS, FRANCE.; Centre De Recherche Des Cordeliers, UMRS-1138, INSERM, Sorbone Université De Paris, Equipe ETREs (Ethics, Research, Translations), Paris, France.
Jallu V; Département d'Immunologie Plaquettaire, Institut National De La Transfusion Sanguine (INTS), Paris, France.; Centre National de Référence en Hémobiologie Périnatale (CNRHP), Site St Antoine, DMU Biologie et Génomique Médicales, AP-HP, Sorbonne Université PARIS, FRANCE.
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Źródło :
Platelets [Platelets] 2022 May 19; Vol. 33 (4), pp. 551-561. Date of Electronic Publication: 2021 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Platelet Glycoprotein GPIIb-IIIa Complex*/metabolism
Thrombasthenia*/genetics
Thrombasthenia*/metabolism
Epidermal Growth Factor ; HEK293 Cells ; Humans ; Integrin beta3/genetics ; Turkey
Czasopismo naukowe
Tytuł :
Rational design, synthesis, antiproliferative activity against MCF-7, MDA-MB-231 cells, estrogen receptors binding affinity, and computational study of indenopyrimidine-2,5-dione analogs for the treatment of breast cancer.
Autorzy :
Ejaz I; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan.
Javed MA; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan.
Jan MS; Department of Pharmacy, University of Swabi, Swabi 23430, KP, Pakistan.
Ikram M; Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan.
Sadiq A; Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18000 Dir (L), KP, Pakistan.
Ahmad S; Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, 18000 Dir (L), KP, Pakistan.
Rashid U; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 May 15; Vol. 64, pp. 128668. Date of Electronic Publication: 2022 Mar 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms*/drug therapy
Breast Neoplasms*/metabolism
Receptors, Estrogen*/metabolism
Cell Proliferation ; Estradiol ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Female ; HEK293 Cells ; Humans ; MCF-7 Cells
Czasopismo naukowe
Tytuł :
Intestinal absorption mechanism of rotundic acid: Involvement of P-gp and OATP2B1.
Autorzy :
Shang H; State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China; Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, 300192, China.
Sun Y; Research Center of Bio-Technology, Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China.
Wang Z; College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.
Zhou Y; State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China.
Yang H; State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China.
Ci X; Research Center of Bio-Technology, Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China.
Cui T; Research Center of Bio-Technology, Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China.
Xia Y; Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China; Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Gu Y; Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China; Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Liao M; State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China; Tianjin Ringpu Bio-technology Co., Ltd., Tianjin, 300308, China. Electronic address: .
Li Q; State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China.
Si D; State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China; Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China; Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Liu C; State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China; Tianjin Institute of Pharmaceutical Research, Tianjin, 300000, China; Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences, Beijing, 100730, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2022 May 10; Vol. 289, pp. 115006. Date of Electronic Publication: 2022 Jan 17.
Typ publikacji :
Journal Article
MeSH Terms :
Intestinal Absorption*
Aquifoliaceae/*chemistry
Triterpenes/*pharmacokinetics
ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Biological Transport ; Caco-2 Cells ; Chromatography, Liquid ; Dogs ; HEK293 Cells ; Humans ; Madin Darby Canine Kidney Cells ; Male ; Organic Anion Transporters/metabolism ; Plant Bark ; Rats ; Rats, Sprague-Dawley ; Solubility ; Tandem Mass Spectrometry ; Triterpenes/chemistry ; Triterpenes/isolation & purification
Czasopismo naukowe
Tytuł :
In-vitro and in-vivo anti-allergic effects of magnolol on allergic rhinitis via inhibition of ORAI1 and ANO1 channels.
Autorzy :
Phan HTL; Department of Physiology, Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju, 38066, Republic of Korea; Channelopathy Research Center (CRC), Dongguk University College of Medicine, 32 Dongguk-ro, Ilsan Dong-gu, Goyang, Gyeonggi-do, 10326, Republic of Korea.
Nam YR; Channelopathy Research Center (CRC), Dongguk University College of Medicine, 32 Dongguk-ro, Ilsan Dong-gu, Goyang, Gyeonggi-do, 10326, Republic of Korea.
Kim HJ; Channelopathy Research Center (CRC), Dongguk University College of Medicine, 32 Dongguk-ro, Ilsan Dong-gu, Goyang, Gyeonggi-do, 10326, Republic of Korea.
Woo JH; Department of Physiology, Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju, 38066, Republic of Korea.
NamKung W; Department of Integrated OMICS for Biomedical Science, WCU Program of Graduate School, Yonsei University, Seoul, 03722, Republic of Korea.
Nam JH; Department of Physiology, Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju, 38066, Republic of Korea; Channelopathy Research Center (CRC), Dongguk University College of Medicine, 32 Dongguk-ro, Ilsan Dong-gu, Goyang, Gyeonggi-do, 10326, Republic of Korea. Electronic address: .
Kim WK; Channelopathy Research Center (CRC), Dongguk University College of Medicine, 32 Dongguk-ro, Ilsan Dong-gu, Goyang, Gyeonggi-do, 10326, Republic of Korea; Department of Internal Medicine Graduate School of Medicine, Dongguk University, 27 Dongguk-ro, Ilsan Dong-gu, Goyang, Gyeonggi-do, 10326, Republic of Korea. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2022 May 10; Vol. 289, pp. 115061. Date of Electronic Publication: 2022 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Allergic Agents/*pharmacology
Biphenyl Compounds/*pharmacology
Lignans/*pharmacology
Magnolia/*chemistry
Rhinitis, Allergic/*drug therapy
Animals ; Anoctamin-1/antagonists & inhibitors ; Anti-Allergic Agents/administration & dosage ; Anti-Allergic Agents/isolation & purification ; Biphenyl Compounds/administration & dosage ; Biphenyl Compounds/isolation & purification ; Cell Line, Tumor ; Cytokines/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Flowers ; HEK293 Cells ; Humans ; Lignans/administration & dosage ; Lignans/isolation & purification ; Mice ; Mice, Inbred BALB C ; Neoplasm Proteins/antagonists & inhibitors ; ORAI1 Protein/antagonists & inhibitors ; Ovalbumin ; Patch-Clamp Techniques
Czasopismo naukowe
Tytuł :
Synergistic mechanism for the bioactivity fortification of licorice by honey.
Autorzy :
Kong S; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Nanxiaojie 16, Dongzhimennei Ave, 100700, Beijing, China. Electronic address: .
Li P; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Nanxiaojie 16, Dongzhimennei Ave, 100700, Beijing, China. Electronic address: .
Verpoorte R; Natural Products Laboratory, Institute of Biology, Leiden University, Sylviusweg 72, 2333BE, Leiden, the Netherlands. Electronic address: .
Wang J; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Nanxiaojie 16, Dongzhimennei Ave, 100700, Beijing, China. Electronic address: .
Zhu C; College of Medicine & Nursing, Dezhou University, Daxue Xi Lu 566, Decheng District, 253023, Shandong, China. Electronic address: .
Dai Y; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Nanxiaojie 16, Dongzhimennei Ave, 100700, Beijing, China. Electronic address: .
Chen S; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Nanxiaojie 16, Dongzhimennei Ave, 100700, Beijing, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2022 May 10; Vol. 289, pp. 115048. Date of Electronic Publication: 2022 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Honey*
Glycyrrhiza/*chemistry
Immunologic Factors/*pharmacology
Plant Extracts/*pharmacology
Animals ; Drug Synergism ; HEK293 Cells ; Humans ; Immunologic Factors/chemistry ; Male ; Mice ; Mice, Inbred ICR ; Plant Extracts/chemistry ; Rats ; Rats, Sprague-Dawley ; Spectroscopy, Fourier Transform Infrared
Czasopismo naukowe
Tytuł :
Personalised medicines for familial hypercalcemia and hyperparathyroidism.
Autorzy :
Josephs TM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Zhang F; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Dinh LV; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Keller AN; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Conigrave AD; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
Capuano B; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Gregory KJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Leach K; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
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Źródło :
Journal of molecular endocrinology [J Mol Endocrinol] 2022 May 09; Vol. 69 (1), pp. 243-257. Date of Electronic Publication: 2022 May 09.
Typ publikacji :
Journal Article
MeSH Terms :
Hypercalcemia*/drug therapy
Hypercalcemia*/genetics
Hypercalcemia*/metabolism
Hyperparathyroidism, Primary*/drug therapy
Hyperparathyroidism, Primary*/genetics
Calcium/metabolism ; Cinacalcet/pharmacology ; Cinacalcet/therapeutic use ; HEK293 Cells ; Humans ; Infant, Newborn ; Mutation ; Precision Medicine ; Receptors, Calcium-Sensing/genetics ; Receptors, Calcium-Sensing/metabolism
Czasopismo naukowe
Tytuł :
Short communication: Feasibility of dengue vaccine to infect different human cell lines: An alternative potency test using HEK293T cells.
Autorzy :
Faria de Carvalho R; Viral Vaccines Laboratory, National Institute of Quality Control in Health, FIOCRUZ, Rio de Janeiro, Brazil.; Post-Graduation Program in Sanitary Surveillance, National Institute of Quality Control in Health, FIOCRUZ, Rio de Janeiro, Brazil.
de Siqueira Penna Quintaes L; Viral Vaccines Laboratory, National Institute of Quality Control in Health, FIOCRUZ, Rio de Janeiro, Brazil.
de Cássia de Souza Su T; Viral Vaccines Laboratory, National Institute of Quality Control in Health, FIOCRUZ, Rio de Janeiro, Brazil.
Mitiko Kobayashi L; Viral Vaccines Laboratory, National Institute of Quality Control in Health, FIOCRUZ, Rio de Janeiro, Brazil.
Martins de Almeida Nogueira AC; Post-Graduation Program in Sanitary Surveillance, National Institute of Quality Control in Health, FIOCRUZ, Rio de Janeiro, Brazil.; Clinical Immunology Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
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Źródło :
PloS one [PLoS One] 2022 May 06; Vol. 17 (5), pp. e0267653. Date of Electronic Publication: 2022 May 06 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Dengue*/prevention & control
Dengue Vaccines*
Animals ; Antibodies, Neutralizing ; Antibodies, Viral ; Chlorocebus aethiops ; Feasibility Studies ; HEK293 Cells ; Humans ; Vaccines, Attenuated ; Vaccines, Combined ; Vero Cells
Czasopismo naukowe
Tytuł :
Functional analysis of LFRFamide signaling in Pacific abalone, Haliotis discus hannai.
Autorzy :
Yoon S; Department of Marine Bioscience, Gangneung-Wonju National University, Gangneung, Gangwon-do, Republic of Korea.
Kim MA; Department of Marine Bioscience, Gangneung-Wonju National University, Gangneung, Gangwon-do, Republic of Korea.; East Coast Life Sciences Institute, Gangneung-Wonju National University, Gangneung, Gangwon, Republic of Korea.
Lee JS; Department of Aqualife Medicine, Chonnam National University, Gwangju, Jeonnam, Republic of Korea.
Sohn YC; Department of Marine Bioscience, Gangneung-Wonju National University, Gangneung, Gangwon-do, Republic of Korea.
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Źródło :
PloS one [PLoS One] 2022 May 05; Vol. 17 (5), pp. e0267039. Date of Electronic Publication: 2022 May 05 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Gastropoda*/physiology
Amino Acids/metabolism ; Animals ; Female ; HEK293 Cells ; Humans ; Neuropeptides ; Peptides/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
De novo variants in ATP2B1 lead to neurodevelopmental delay.
Autorzy :
Rahimi MJ; Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig 04103, Germany.
Urban N; Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig Hospitals and Clinics, Leipzig 04107, Germany.
Wegler M; Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig 04103, Germany.
Sticht H; Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91054, Germany.
Schaefer M; Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig Hospitals and Clinics, Leipzig 04107, Germany.
Popp B; Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig 04103, Germany.
Gaunitz F; Department of Neurosurgery, University of Leipzig Hospitals and Clinics, Leipzig 04103, Germany.
Morleo M; Telethon Institute of Genetics and Medicine, Pozzuoli, 80078 Naples, Italy; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli,' Naples 80138, Italy.
Nigro V; Telethon Institute of Genetics and Medicine, Pozzuoli, 80078 Naples, Italy; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli,' Naples 80138, Italy.
Maitz S; Clinical Pediatric Genetic Unit, Pediatric Clinic, Fondazione MBBM, San Gerardo Hospital, Monza 20900, Italy.
Mancini GMS; ErasmusMC University Medical Center, Department of Clinical Genetics, Rotterdam 3015, the Netherlands.
Ruivenkamp C; Leiden University Medical Center, Clinical Genetics, Leiden 2333, the Netherlands.
Suk EK; Praxis für Humangenetik-Friedrichstrasse, Berlin 10117, Germany.
Bartolomaeus T; Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig 04103, Germany; CeGaT GmbH and Praxis für Humangenetik Tübingen, Tübingen 72076, Germany.
Merkenschlager A; Department of Neuropediatrics, University of Leipzig Hospitals and Clinics, Leipzig 04103, Germany.
Koboldt D; Institute for Genomic Medicine at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Bartholomew D; Division of Genetic and Genomic Medicine at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Stegmann APA; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht 6229, the Netherlands.
Sinnema M; Department of Clinical Genetics, Maastricht University Medical Center+, Maastricht 6229, the Netherlands.
Duynisveld I; Severinus Institute for Intellectual Disability, 5507 Veldhoven, the Netherlands.
Salvarinova R; Division of Biochemical Genetics, Department of Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, BC V6H 3N1, Canada.
Race S; Division of Biochemical Genetics, Department of Pediatrics, University of British Columbia, BC Children's Hospital, Vancouver, BC V6H 3N1, Canada.
de Vries BBA; Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen 6525, the Netherlands.
Trimouille A; Service de Pathologie Centre Hospitalier Universitaire de Bordeaux, Bordeaux 33000, France; MRGM, Maladies Rares: Génétique et Métabolisme, INSERM U1211, Université de Bordeaux, Bordeaux 33076, France.
Naudion S; Service de Génétique Médicale, Centre Hospitalier Universitaire de Bordeaux, Bordeaux 33076, France.
Marom D; The Genetics Institute, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.
Hamiel U; The Genetics Institute, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.
Henig N; The Genetics Institute, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel.
Demurger F; Service de Génértique, CHBA, Vannes 56000, France.
Rahner N; Institute for Clinical Genetics, Bonn 53111, Germany.
Bartels E; Institute for Clinical Genetics, Bonn 53111, Germany.
Hamm JA; Pediatric Genetics, East Tennessee Children's Hospital, Knoxville, TN 37916, USA.
Putnam AM; Pediatric Genetics, East Tennessee Children's Hospital, Knoxville, TN 37916, USA.
Person R; Clinical Genomics Program, GeneDx, Inc., Gaithersburg, MD 20877, USA.
Abou Jamra R; Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig 04103, Germany.
Oppermann H; Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig 04103, Germany. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2022 May 05; Vol. 109 (5), pp. 944-952. Date of Electronic Publication: 2022 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Intellectual Disability*/diagnosis
Intellectual Disability*/genetics
Nervous System Malformations*
Neurodevelopmental Disorders*/genetics
HEK293 Cells ; Humans ; Mutation, Missense/genetics ; Phenotype ; Plasma Membrane Calcium-Transporting ATPases/genetics
Czasopismo naukowe
Tytuł :
Functional validation of variants of unknown significance using CRISPR gene editing and transcriptomics: A Kleefstra syndrome case study.
Autorzy :
Fear VS; Translational Genetics, Precision Health, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia; Computational Biology, Precision Health, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia. Electronic address: .
Forbes CA; Translational Genetics, Precision Health, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia; Computational Biology, Precision Health, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia.
Anderson D; Computational Biology, Precision Health, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia.
Rauschert S; Computational Biology, Precision Health, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia.
Syn G; Computational Biology, Precision Health, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia.
Shaw N; Translational Genetics, Precision Health, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia.
Jones ME; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA 6009, Australia.
Forrest AR; Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Nedlands, Perth, WA 6009, Australia.
Baynam G; Western Australian Register of Developmental Anomalies, King Edward Memorial Hospital, Subiaco, Western Australia, 6008, Australia; Faculty of Health and Medical Sciences, University of Western Australia, Crawley, Western Australia, 6009, Australia; Undiagnosed Diseases Program, Genetic Services of WA, Australia.
Lassmann T; Translational Genetics, Precision Health, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia; Computational Biology, Precision Health, Telethon Kids Institute, Perth Children's Hospital, Nedlands, Western Australia, 6009, Australia.
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Źródło :
Gene [Gene] 2022 May 05; Vol. 821, pp. 146287. Date of Electronic Publication: 2022 Feb 14.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Regulatory Networks*
Craniofacial Abnormalities/*diagnosis
Gene Editing/*methods
Gene Expression Profiling/*methods
Heart Defects, Congenital/*diagnosis
Histone-Lysine N-Methyltransferase/*genetics
Intellectual Disability/*diagnosis
CRISPR-Cas Systems ; Chromosome Deletion ; Chromosomes, Human, Pair 19/genetics ; Chromosomes, Human, Pair 9/genetics ; Chromosomes, Human, X/genetics ; Craniofacial Abnormalities/genetics ; Early Diagnosis ; Gene Expression Regulation ; Genetic Variation ; HEK293 Cells ; Heart Defects, Congenital/genetics ; Humans ; Intellectual Disability/genetics ; Proof of Concept Study ; Sequence Analysis, RNA
SCR Disease Name :
Kleefstra Syndrome
Czasopismo naukowe
Tytuł :
Regulation of c-Fos gene transcription by stimulus-responsive protein kinases.
Autorzy :
Dalhäusser AK; Department of Medical Biochemistry and Molecular Biology, Saarland University Medical Faculty, D-66421 Homburg, Germany.
Rössler OG; Department of Medical Biochemistry and Molecular Biology, Saarland University Medical Faculty, D-66421 Homburg, Germany.
Thiel G; Department of Medical Biochemistry and Molecular Biology, Saarland University Medical Faculty, D-66421 Homburg, Germany. Electronic address: .
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Źródło :
Gene [Gene] 2022 May 05; Vol. 821, pp. 146284. Date of Electronic Publication: 2022 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Proto-Oncogene Proteins c-fos/*genetics
Serum Response Factor/*metabolism
TCF Transcription Factors/*metabolism
Tamoxifen/*analogs & derivatives
Gene Expression Regulation/drug effects ; HEK293 Cells ; Humans ; MAP Kinase Signaling System ; Mitogen-Activated Protein Kinases/metabolism ; Mutation ; Promoter Regions, Genetic ; Serum Response Element ; Tamoxifen/pharmacology ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Systematic identification of ALK substrates by integrated phosphoproteome and interactome analysis.
Autorzy :
Adachi J; Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan .; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Laboratory of Proteomics and Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Kakudo A; Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Takada Y; Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Isoyama J; Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Ikemoto N; Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Abe Y; Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Narumi R; Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Muraoka S; Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Gunji D; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hara Y; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Katayama R; Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Tomonaga T; Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
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Źródło :
Life science alliance [Life Sci Alliance] 2022 May 04; Vol. 5 (8). Date of Electronic Publication: 2022 May 04 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Proteome*/metabolism
Signal Transduction*
Anaplastic Lymphoma Kinase/metabolism ; HEK293 Cells ; Humans ; Phosphorylation
Czasopismo naukowe
Tytuł :
Mutagenicity and safety pharmacology of a standardized antidiabetic polyherbal formulation.
Autorzy :
Abdul Majid FA; Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia. .
Fadhlina A; Institute of Food Security and Sustainable Agriculture, Universiti Malaysia Kelantan, Jeli campus, 17600, Jeli, Kelantan, Malaysia.
Ismail HF; Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.
Zainol SN; Proliv Life Sciences Sdn Bhd, D-1-15, Residensi Bistaria, Jln Ulu Kelang, Taman Ukay Bistari, 68000, Ampang, Selangor, Malaysia.
Mamillapalli AK; Aurigene Pharmaceutical Services Limited, Bollaram Road, Miyapur, Hyderabad, Telangana, 500 049, India.
Venkatesan V; Aurigene Pharmaceutical Services Limited, Bollaram Road, Miyapur, Hyderabad, Telangana, 500 049, India.
Eswarappa R; Aurigene Pharmaceutical Services Limited, Bollaram Road, Miyapur, Hyderabad, Telangana, 500 049, India.
Pillai R; Aurigene Pharmaceutical Services Limited, Bollaram Road, Miyapur, Hyderabad, Telangana, 500 049, India.
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Źródło :
Scientific reports [Sci Rep] 2022 May 03; Vol. 12 (1), pp. 7127. Date of Electronic Publication: 2022 May 03.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoglycemic Agents*/toxicity
Mutagens*/toxicity
Animals ; HEK293 Cells ; Humans ; Mutagenicity Tests ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.
Autorzy :
Brody AH; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Nies SH; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, CT, USA.; Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, D-72074, Tübingen, Germany.
Guan F; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Smith LM; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Mukherjee B; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Salazar SA; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Lee S; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Lam TKT; Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT, USA.; Keck MS & Proteomics Resource, Yale School of Medicine, New Haven, CT, USA.
Strittmatter SM; Cellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale School of Medicine, New Haven, CT, USA. .
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Źródło :
Molecular neurodegeneration [Mol Neurodegener] 2022 May 03; Vol. 17 (1), pp. 32. Date of Electronic Publication: 2022 May 03.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease*/pathology
Tauopathies*/metabolism
Amyloid beta-Peptides/metabolism ; Animals ; Focal Adhesion Kinase 2/genetics ; Focal Adhesion Kinase 2/metabolism ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Phenotype ; Phosphorylation ; Proteomics ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Caveolin-3 prevents swelling-induced membrane damage via regulation of I Cl,swell activity.
Autorzy :
Turner DGP; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Tyan L; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
DeGuire FC; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Medvedev RY; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Stroebel SJ; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Lang D; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin.
Glukhov AV; Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin. Electronic address: .
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Źródło :
Biophysical journal [Biophys J] 2022 May 03; Vol. 121 (9), pp. 1643-1659. Date of Electronic Publication: 2022 Apr 02.
Typ publikacji :
Journal Article
MeSH Terms :
Chlorides*/metabolism
Caveolin 3/*metabolism
Animals ; Butyric Acid ; Cell Size ; Chloride Channels/metabolism ; HEK293 Cells ; Humans ; Membrane Proteins/metabolism ; Mice
Czasopismo naukowe

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