Temat: "HEK293 Cells" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Evolution from adherent to suspension: systems biology of HEK293 cell line development.
Autorzy :: Malm M; KTH - School of Engineering Sciences in Chemistry, Biotechnology, and Health, Dept. of Protein Science, Royal Institute of Technology, 106 91, Stockholm, Sweden.
Saghaleyni R; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96, Gothenburg, Sweden.
Lundqvist M; KTH - School of Engineering Sciences in Chemistry, Biotechnology, and Health, Dept. of Protein Science, Royal Institute of Technology, 106 91, Stockholm, Sweden.
Giudici M; KTH - School of Engineering Sciences in Chemistry, Biotechnology, and Health, Dept. of Protein Science, Royal Institute of Technology, 106 91, Stockholm, Sweden.
Chotteau V; KTH - School of Engineering Sciences in Chemistry, Biotechnology, and Health, Dept. of Protein Science, Royal Institute of Technology, 106 91, Stockholm, Sweden.
Field R; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK.; GammaDelta Therapeutics Ltd, White City Place, London, W12 7FQ, UK.
Varley PG; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK.; Kymab, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Hatton D; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK.
Grassi L; Biopharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK.
Svensson T; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96, Gothenburg, Sweden.; NBIS - Bioinformatics Systems Biology Support, Chalmers University of Technology, 412 96, Gothenburg, Sweden.
Nielsen J; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96, Gothenburg, Sweden. .; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kongens Lyngby, Denmark. .
Rockberg J; KTH - School of Engineering Sciences in Chemistry, Biotechnology, and Health, Dept. of Protein Science, Royal Institute of Technology, 106 91, Stockholm, Sweden. .; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2020 Nov 04; Vol. 10 (1), pp. 18996. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Gene Expression Profiling/*methods
HEK293 Cells/*cytology
Metabolomics/*methods
Cell Adhesion ; Cell Culture Techniques ; Cell Movement ; Cholesterol/biosynthesis ; Gene Dosage ; Gene Expression Regulation ; Gene Regulatory Networks ; HEK293 Cells/chemistry ; Humans ; Protein Engineering
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 2 2.

Tytuł :: Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues.
Autorzy :: Zhang L; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Richards A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Barrasa MI; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Hughes SH; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.
Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.
Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; .; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.; Pokaż więcej
Źródło :: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 May 25; Vol. 118 (21).
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :: COVID-19/*genetics
COVID-19/*virology
SARS-CoV-2/*genetics
Virus Integration/*genetics
Animals ; COVID-19/metabolism ; Chlorocebus aethiops ; Genome, Viral ; HEK293 Cells ; Humans ; RNA, Viral/genetics ; SARS-CoV-2/metabolism ; Vero Cells ; Virus Integration/physiology ; Virus Replication/genetics ; Virus Replication/physiology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: WIPI1 promotes osteosarcoma cell proliferation by inhibiting CDKN1A.
Autorzy :: Ran T; Orthopeadic Dept. Xinqiao Hospital, Army Medical University, Chongqing, China.
Ke S; Orthopeadic Dept. Xinqiao Hospital, Army Medical University, Chongqing, China.
Song X; Orthopeadic Dept. Xinqiao Hospital, Army Medical University, Chongqing, China.
Ma T; Orthopeadic Dept. Xinqiao Hospital, Army Medical University, Chongqing, China.
Xu Y; Orthopeadic Dept. Xinqiao Hospital, Army Medical University, Chongqing, China.
Wang M; Orthopeadic Dept. Xinqiao Hospital, Army Medical University, Chongqing, China. Electronic address: .; Pokaż więcej
Źródło :: Gene [Gene] 2021 May 25; Vol. 782, pp. 145537. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :: Journal Article
MeSH Terms :: Autophagy-Related Proteins/*genetics
Bone Neoplasms/*genetics
Cell Proliferation/*genetics
Cyclin-Dependent Kinase Inhibitor p21/*antagonists & inhibitors
Membrane Proteins/*genetics
Osteosarcoma/*genetics
Animals ; Autophagy-Related Proteins/physiology ; Bone Neoplasms/pathology ; Cell Cycle/genetics ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Gene Expression Regulation, Neoplastic ; Genetic Vectors ; HEK293 Cells ; Humans ; Lentivirus/genetics ; Membrane Proteins/physiology ; Mice, Nude ; Oligonucleotide Array Sequence Analysis ; Osteosarcoma/pathology ; Software ; Transcriptome
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: The baculovirus promoter OpIE2 sequence has inhibitory effect on the activity of the cytomegalovirus (CMV) promoter in HeLa and HEK-293 T cells.
Autorzy :: Aladdin A; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, October Gardens, 6th of October City, Giza 12578, Egypt.
Sahly N; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, October Gardens, 6th of October City, Giza 12578, Egypt.
Faty R; Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
Youssef MM; Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
Salem TZ; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, October Gardens, 6th of October City, Giza 12578, Egypt; Department of Molecular Genetics, AGERI, ARC, Giza 12619, Egypt; National Biotechnology Network of Expertise (NBNE), Academy of Science Research and Technology (ASRT), 11334 Cairo, Egypt. Electronic address: .; Pokaż więcej
Źródło :: Gene [Gene] 2021 May 20; Vol. 781, pp. 145541. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :: Journal Article
MeSH Terms :: Gene Expression Regulation, Viral*
Genetic Vectors*
Baculoviridae/*genetics
Cytomegalovirus/*genetics
Promoter Regions, Genetic/*genetics
Animals ; Binding Sites ; Computer Simulation ; DNA, Recombinant/genetics ; DNA, Recombinant/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Sf9 Cells ; Transcription Factors/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Identification of SARS-CoV-2 viral entry inhibitors using machine learning and cell-based pseudotyped particle assay.
Autorzy :: Sun H; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, USA.
Wang Y; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, USA.
Chen CZ; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, USA.
Xu M; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, USA.
Guo H; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, USA.
Itkin M; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, USA.
Zheng W; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, USA.
Shen M; National Center for Advancing Translational Sciences (NCATS), 9800 Medical Center Dr., Rockville, MD 20850, USA. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 May 15; Vol. 38, pp. 116119. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :: Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :: Antiviral Agents/*pharmacology
SARS-CoV-2/*drug effects
Support Vector Machine/*statistics & numerical data
Virus Internalization/*drug effects
Area Under Curve ; Databases, Chemical/statistics & numerical data ; Drug Repositioning ; HEK293 Cells ; Humans ; Microbial Sensitivity Tests ; ROC Curve ; Small Molecule Libraries/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Functional characterization of N-octyl 4-methylamphetamine variants and related bivalent compounds at the dopamine and serotonin transporters using Ca channels as sensors.
Autorzy :: Ruchala I; Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, United States of America.
Battisti UM; Deparment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, United States of America.
Nguyen VT; Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, United States of America.
Chen RY; Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, United States of America.
Glennon RA; Deparment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, United States of America.
Eltit JM; Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, United States of America. Electronic address: .; Pokaż więcej
Źródło :: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 May 15; Vol. 419, pp. 115513. Date of Electronic Publication: 2021 Mar 27.
Typ publikacji :: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :: Biosensing Techniques*
Calcium/*metabolism
Calcium Channels/*metabolism
Dopamine Plasma Membrane Transport Proteins/*antagonists & inhibitors
Dopamine Uptake Inhibitors/*toxicity
Green Fluorescent Proteins/*metabolism
Methamphetamine/*toxicity
Serotonin Plasma Membrane Transport Proteins/*drug effects
Serotonin Uptake Inhibitors/*toxicity
Calcium Channels/genetics ; Dopamine Plasma Membrane Transport Proteins/genetics ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Green Fluorescent Proteins/genetics ; HEK293 Cells ; Humans ; Methamphetamine/analogs & derivatives ; Methamphetamine/chemical synthesis ; Microscopy, Fluorescence ; Molecular Structure ; Serotonin Plasma Membrane Transport Proteins/genetics ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Structure-Activity Relationship ; Time Factors
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: SARS-CoV-2 S1 NanoBiT: A nanoluciferase complementation-based biosensor to rapidly probe SARS-CoV-2 receptor recognition.
Autorzy :: Azad T; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Singaravelu R; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Brown EEF; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Taha Z; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Rezaei R; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Arulanandam R; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.
Boulton S; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Diallo JS; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Ilkow CS; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Bell JC; Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. Electronic address: .; Pokaż więcej
Źródło :: Biosensors & bioelectronics [Biosens Bioelectron] 2021 May 15; Vol. 180, pp. 113122. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :: Journal Article
MeSH Terms :: SARS-CoV-2*
Angiotensin-Converting Enzyme 2/*chemistry
Biosensing Techniques/*methods
COVID-19/*diagnosis
Luminescent Measurements/*methods
Spike Glycoprotein, Coronavirus/*chemistry
HEK293 Cells ; Humans ; Luciferases ; Neutralization Tests ; Virus Internalization
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: PEDOT:PSS organic electrochemical transistors for electrical cell-substrate impedance sensing down to single cells.
Autorzy :: Hempel F; Department of Informatics and Microsystem Technology, University of Applied Sciences Kaiserslautern, Campus Zweibruecken, 66482, Zweibruecken, Germany.
Law JKY; Department of Informatics and Microsystem Technology, University of Applied Sciences Kaiserslautern, Campus Zweibruecken, 66482, Zweibruecken, Germany.
Nguyen TC; Department of Informatics and Microsystem Technology, University of Applied Sciences Kaiserslautern, Campus Zweibruecken, 66482, Zweibruecken, Germany.
Lanche R; Department of Informatics and Microsystem Technology, University of Applied Sciences Kaiserslautern, Campus Zweibruecken, 66482, Zweibruecken, Germany.
Susloparova A; Department of Informatics and Microsystem Technology, University of Applied Sciences Kaiserslautern, Campus Zweibruecken, 66482, Zweibruecken, Germany.
Vu XT; Department of Informatics and Microsystem Technology, University of Applied Sciences Kaiserslautern, Campus Zweibruecken, 66482, Zweibruecken, Germany; Institute of Materials in Electrical Engineering 1, RWTH Aachen University, 52074, Aachen, Germany.
Ingebrandt S; Department of Informatics and Microsystem Technology, University of Applied Sciences Kaiserslautern, Campus Zweibruecken, 66482, Zweibruecken, Germany; Institute of Materials in Electrical Engineering 1, RWTH Aachen University, 52074, Aachen, Germany. Electronic address: .; Pokaż więcej
Źródło :: Biosensors & bioelectronics [Biosens Bioelectron] 2021 May 15; Vol. 180, pp. 113101. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :: Journal Article
MeSH Terms :: Biosensing Techniques*
Bridged Bicyclo Compounds, Heterocyclic ; Electric Impedance ; HEK293 Cells ; Humans ; Polymers
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: 2-Undecanone Protects against Fine Particle-Induced Kidney Inflammation via Inducing Mitophagy.
Autorzy :: Wu X; Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian 116044, China.
Li J; Department of Pathology, Dalian Medical University, Dalian 116044, China.
Wang S; Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Jiang L; Liaoning Anti-degenerative Diseases, Natural Products Engineering Technology Research Center, Dalian Medical University, Dalian 116044, China.
Sun X; Liaoning Anti-degenerative Diseases, Natural Products Engineering Technology Research Center, Dalian Medical University, Dalian 116044, China.
Liu X; Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian 116044, China.
Yao X; Liaoning Anti-degenerative Diseases, Natural Products Engineering Technology Research Center, Dalian Medical University, Dalian 116044, China.
Zhang C; Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian 116044, China.
Wang N; Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian 116044, China.
Yang G; Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian 116044, China.; Pokaż więcej
Źródło :: Journal of agricultural and food chemistry [J Agric Food Chem] 2021 May 05; Vol. 69 (17), pp. 5206-5215. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :: Journal Article
MeSH Terms :: Mitophagy*
Particulate Matter*/toxicity
Animals ; HEK293 Cells ; Humans ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/genetics ; Ketones ; Kidney ; Mice ; Mice, Inbred BALB C
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: TGM6 might not be a specific causative gene for spinocerebellar ataxia resulting from genetic analysis and functional study.
Autorzy :: Cheng HL; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China; Department of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Dong HL; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Liu DS; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Ni W; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Ma Y; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Yang L; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Du YC; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Chen DF; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
Dong Y; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: .
Wu ZY; Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: .; Pokaż więcej
Źródło :: Gene [Gene] 2021 May 05; Vol. 779, pp. 145495. Date of Electronic Publication: 2021 Feb 13.
Typ publikacji :: Journal Article
MeSH Terms :: Spinocerebellar Ataxias/*genetics
Transglutaminases/*genetics
Aged ; Case-Control Studies ; Female ; Gene Frequency ; HEK293 Cells ; Humans ; Mutation ; Pedigree ; Spinocerebellar Ataxias/etiology ; Transglutaminases/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Inhibition of Bitter Taste from Oral Tenofovir Alafenamide.
Autorzy :: Schwiebert E; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.) .
Wang Y; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.).
Xi R; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.).
Choma K; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.).
Streiff J; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.).
Flammer LJ; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.).
Rivers N; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.).
Ozdener MH; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.).
Margolskee RF; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.).
Christensen CM; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.).
Rawson NE; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.).
Jiang P; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.) .
Breslin PAS; Discovery Biomed, Birmingham, Alabama (E.S., J.S.); Monell Chemical Senses Center, Philadelphia, Pennsylvania (Y.W., R.X., K.C., L.J.F., N.R., M.H.O., R.F.M., C.M.C., N.E.R., P.J., P.A.S.B.); and Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey (P.A.S.B.) .; Pokaż więcej
Źródło :: Molecular pharmacology [Mol Pharmacol] 2021 May; Vol. 99 (5), pp. 319-327. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Adenine/*analogs & derivatives
Flavoring Agents/*administration & dosage
Flavoring Agents/*chemistry
Taste/*drug effects
Taste Buds/*drug effects
Adenine/adverse effects ; Adenine/chemistry ; Adult ; Antiviral Agents/adverse effects ; Antiviral Agents/chemistry ; Cell Line ; Female ; Flavones/administration & dosage ; Flavones/chemistry ; HEK293 Cells ; Humans ; Male ; Receptors, Cell Surface/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Taste Buds/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Green Formulation of Microbial Biopolyesteric Nanocarriers Toward In Vitro Drug Delivery and Its Characterization.
Autorzy :: Ojha N; Bioremediation Laboratory, Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.
Das N; Bioremediation Laboratory, Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India. .; Pokaż więcej
Źródło :: Current microbiology [Curr Microbiol] 2021 May; Vol. 78 (5), pp. 2061-2070. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :: Journal Article
MeSH Terms :: Nanoparticles*
Pharmaceutical Preparations*
Anti-Bacterial Agents/pharmacology ; Escherichia coli ; HEK293 Cells ; Humans ; Particle Size ; Spectroscopy, Fourier Transform Infrared ; Staphylococcus aureus ; X-Ray Diffraction
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.
Autorzy :: Collier DA; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Infection and Immunity, University College London, London, UK.
De Marco A; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Ferreira IATM; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.
Meng B; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.
Datir RP; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Infection and Immunity, University College London, London, UK.
Walls AC; Department of Biochemistry, University of Washington, Seattle, WA, USA.
Kemp SA; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Infection and Immunity, University College London, London, UK.
Bassi J; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Pinto D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Silacci-Fregni C; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Bianchi S; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA, USA.
Bowen J; Department of Biochemistry, University of Washington, Seattle, WA, USA.
Culap K; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Jaconi S; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Cameroni E; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Snell G; Vir Biotechnology, San Francisco, CA, USA.
Pizzuto MS; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Pellanda AF; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland.
Garzoni C; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland.
Riva A; Division of Infectious Diseases, Luigi Sacco Hospital, University of Milan, Milan, Italy.
Elmer A; NIHR Cambridge Clinical Research Facility, Cambridge, UK.
Kingston N; NIHR Bioresource, Cambridge, UK.
Graves B; NIHR Bioresource, Cambridge, UK.
McCoy LE; Division of Infection and Immunity, University College London, London, UK.
Smith KGC; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.
Bradley JR; Department of Medicine, University of Cambridge, Cambridge, UK.; NIHR Bioresource, Cambridge, UK.
Temperton N; University of Kent, Canturbury, UK.
Ceron-Gutierrez L; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, UK.
Barcenas-Morales G; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, UK.; Laboratorio de Inmunologia, UNAM, Cuautitlán, Mexico.
Harvey W; Institute of Biodiversity, University of Glasgow, Glasgow, UK.
Virgin HW; Vir Biotechnology, San Francisco, CA, USA.
Lanzavecchia A; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Piccoli L; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.
Doffinger R; Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.
Wills M; Department of Medicine, University of Cambridge, Cambridge, UK.
Veesler D; Department of Biochemistry, University of Washington, Seattle, WA, USA.
Corti D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland. .
Gupta RK; Cambridge Institute of Therapeutic Immunology & Infectious Disease, Cambridge, UK. .; Department of Medicine, University of Cambridge, Cambridge, UK. .; Department of Haematology, University of Cambridge, Cambridge, UK. .; University of KwaZulu Natal, Durban, South Africa. .; Africa Health Research Institute, Durban, South Africa. .; Department of Infectious Diseases, Cambridge University Hospitals NHS Trust, Cambridge, UK. .; Pokaż więcej
Corporate Authors :: CITIID-NIHR BioResource COVID-19 Collaboration
COVID-19 Genomics UK (COG-UK) Consortium
Źródło :: Nature [Nature] 2021 May; Vol. 593 (7857), pp. 136-141. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
COVID-19/*therapy
COVID-19 Vaccines/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Vaccines, Synthetic/*immunology
Aged ; Aged, 80 and over ; Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/isolation & purification ; COVID-19/metabolism ; COVID-19/virology ; Female ; HEK293 Cells ; Humans ; Immune Evasion/genetics ; Immune Evasion/immunology ; Immunization, Passive ; Male ; Middle Aged ; Models, Molecular ; Mutation ; Neutralization Tests ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Vaccines, Synthetic/administration & dosage
SCR Protocol :: COVID-19 serotherapy
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 14 14.

Tytuł :: The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca Permeability of GluN1/GluN2A N -Methyl-d-Aspartate Receptors.
Autorzy :: Perszyk RE; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.).
Zheng Z; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.).
Banke TG; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.).
Zhang J; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.).
Xie L; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.).
McDaniel MJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.).
Katzman BM; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.).
Pelly SC; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.).
Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.).
Liotta DC; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.).
Traynelis SF; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia (R.E.P., Z.Z., T.G.B., J.Z., L.X., M.J.M., H.Y., S.F.T.) and Department of Chemistry, Emory University, Atlanta, Georgia (B.M.K., S.C.P., D.C.L.) .; Pokaż więcej
Źródło :: Molecular pharmacology [Mol Pharmacol] 2021 May; Vol. 99 (5), pp. 399-411. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Allosteric Regulation/*drug effects
Calcium/*metabolism
Permeability/*drug effects
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Brain/drug effects ; Brain/metabolism ; Glutamic Acid/metabolism ; Glycine/metabolism ; HEK293 Cells ; Humans ; Xenopus laevis
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7.
Autorzy :: Wang P; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Nair MS; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Liu L; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Iketani S; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Luo Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Guo Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Wang M; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Yu J; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Zhang B; Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Kwong PD; Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.; Department of Biochemistry, Columbia University, New York, NY, USA.
Graham BS; Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Mascola JR; Vaccine Research Center, National Institutes of Health, Bethesda, MD, USA.
Chang JY; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Yin MT; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Sobieszczyk M; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Kyratsous CA; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Shapiro L; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Biochemistry, Columbia University, New York, NY, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Sheng Z; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Huang Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. .
Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. .; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. .; Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. .; Pokaż więcej
Źródło :: Nature [Nature] 2021 May; Vol. 593 (7857), pp. 130-135. Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
COVID-19/*therapy
COVID-19 Vaccines/*immunology
Immune Evasion/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Adult ; Aged ; Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; COVID-19/drug therapy ; COVID-19/prevention & control ; COVID-19/virology ; Chlorocebus aethiops ; Drug Resistance, Viral/immunology ; HEK293 Cells ; Humans ; Immune Evasion/genetics ; Immunization, Passive ; Middle Aged ; Models, Molecular ; Mutation ; Neutralization Tests ; Protein Domains/immunology ; SARS-CoV-2/chemistry ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Vaccines, Synthetic/immunology ; Vero Cells
SCR Protocol :: COVID-19 serotherapy
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels.
Autorzy :: Szendrey M; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Guo J; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Li W; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Yang T; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Zhang S; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada .; Pokaż więcej
Źródło :: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 May; Vol. 377 (2), pp. 265-272. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :: Journal Article
MeSH Terms :: Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Azithromycin/*pharmacology
COVID-19/*drug therapy
Chloroquine/*pharmacology
ERG1 Potassium Channel/*antagonists & inhibitors
Hydroxychloroquine/*pharmacology
Adenosine Monophosphate/pharmacology ; Adenosine Monophosphate/therapeutic use ; Alanine/pharmacology ; Alanine/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Azithromycin/therapeutic use ; COVID-19/metabolism ; Chloroquine/therapeutic use ; Dose-Response Relationship, Drug ; ERG1 Potassium Channel/metabolism ; HEK293 Cells ; Humans ; Hydroxychloroquine/therapeutic use ; Potassium Channel Blockers/pharmacology ; Potassium Channel Blockers/therapeutic use
SCR Protocol :: COVID-19 drug treatment
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: Screening and evaluation of anti-SARS-CoV-2 components from Ephedra sinica by ACE2/CMC-HPLC-IT-TOF-MS approach.
Autorzy :: Lv Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Wang S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Liang P; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Wang Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Zhang X; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Jia Q; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Fu J; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.
Han S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. .; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China. .
He L; School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.; Institute of Pharmaceutical Science and Technology, Western China Science & Technology Innovation Harbour, Xi'an, 710115, Shaanxi, China.; Pokaż więcej
Źródło :: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2021 May; Vol. 413 (11), pp. 2995-3004. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :: Journal Article
MeSH Terms :: Ephedra sinica*/chemistry
Angiotensin-Converting Enzyme 2/*metabolism
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Drugs, Chinese Herbal/*pharmacology
SARS-CoV-2/*drug effects
Antiviral Agents/chemistry ; Antiviral Agents/isolation & purification ; COVID-19/metabolism ; China ; Chromatography, High Pressure Liquid ; Drug Discovery ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Ephedrine/analogs & derivatives ; Ephedrine/isolation & purification ; Ephedrine/pharmacology ; HEK293 Cells ; Humans ; Mass Spectrometry ; Molecular Docking Simulation ; SARS-CoV-2/physiology ; Virus Internalization/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 as Tool Compounds to Study Signaling Bias.
Autorzy :: Arsova A; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia (S.D.H., K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Novo Nordisk Park 1, Måløv, Denmark (J.L.H.).
Møller TC; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia (S.D.H., K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Novo Nordisk Park 1, Måløv, Denmark (J.L.H.).
Hellyer SD; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia (S.D.H., K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Novo Nordisk Park 1, Måløv, Denmark (J.L.H.).
Vedel L; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia (S.D.H., K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Novo Nordisk Park 1, Måløv, Denmark (J.L.H.).
Foster SR; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia (S.D.H., K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Novo Nordisk Park 1, Måløv, Denmark (J.L.H.).
Hansen JL; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia (S.D.H., K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Novo Nordisk Park 1, Måløv, Denmark (J.L.H.).
Bräuner-Osborne H; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia (S.D.H., K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Novo Nordisk Park 1, Måløv, Denmark (J.L.H.) .
Gregory KJ; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A., T.C.M., L.V., S.R.F., H.B.-O.); Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, VIC, Australia (S.D.H., K.J.G.); and Cardiovascular Research, Novo Nordisk A/S, Novo Nordisk Park 1, Måløv, Denmark (J.L.H.) .; Pokaż więcej
Źródło :: Molecular pharmacology [Mol Pharmacol] 2021 May; Vol. 99 (5), pp. 328-341. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Allosteric Regulation/*drug effects
Receptor, Metabotropic Glutamate 5/*metabolism
Signal Transduction/*drug effects
Animals ; Benzamides/pharmacology ; Cell Line ; Fatty Acids/pharmacology ; Female ; HEK293 Cells ; Humans ; MAP Kinase Signaling System/drug effects ; Mice ; Phosphorylation/drug effects ; Pyrazoles/pharmacology ; Rats
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Enzyme-free amplified detection of cellular microRNA by light-harvesting fluorescent nanoparticle probes.
Autorzy :: Egloff S; Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74, Route Du Rhin, 67401, Illkirch, France.
Melnychuk N; Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74, Route Du Rhin, 67401, Illkirch, France.
Reisch A; Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74, Route Du Rhin, 67401, Illkirch, France.
Martin S; Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74, Route Du Rhin, 67401, Illkirch, France.
Klymchenko AS; Laboratoire de Bioimagerie et Pathologies, UMR 7021 CNRS, Faculté de Pharmacie, Université de Strasbourg, 74, Route Du Rhin, 67401, Illkirch, France. Electronic address: .; Pokaż więcej
Źródło :: Biosensors & bioelectronics [Biosens Bioelectron] 2021 May 01; Vol. 179, pp. 113084. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :: Journal Article
MeSH Terms :: Biosensing Techniques*
MicroRNAs*/genetics
Nanoparticles*
Fluorescent Dyes ; HEK293 Cells ; Humans
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: Three salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2.
Autorzy :: Hu S; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, China.; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang J; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, China.; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Zhang Y; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, China.; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Bai H; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, China.; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang C; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, China.; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang N; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, China.; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
He L; School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shannxi, China.; Institute of Vascular Materia Medica, Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Pokaż więcej
Źródło :: Journal of medical virology [J Med Virol] 2021 May; Vol. 93 (5), pp. 3143-3151. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Alkenes/*pharmacology
Angiotensin-Converting Enzyme 2/*metabolism
Benzofurans/*pharmacology
Caffeic Acids/*pharmacology
Lactates/*pharmacology
Polyphenols/*pharmacology
SARS-CoV-2/*drug effects
Spike Glycoprotein, Coronavirus/*metabolism
Alkenes/chemistry ; Angiotensin-Converting Enzyme 2/chemistry ; Benzofurans/chemistry ; COVID-19/drug therapy ; Caffeic Acids/chemistry ; Cell Survival ; HEK293 Cells ; Humans ; Lactates/chemistry ; Molecular Structure ; Polyphenols/chemistry ; Protein Binding ; Spike Glycoprotein, Coronavirus/chemistry ; Virus Internalization
: Czasopismo naukowe

Szczegóły

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