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Tytuł :
Postoperative management of antithrombotic medication in microvascular head and neck reconstruction: a comparative analysis of unfractionated and low-molecular-weight heparin.
Autorzy :
Sievert M; Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg, Waldstrasse 1, 91054, Erlangen, Germany. .
Goncalves M; Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg, Waldstrasse 1, 91054, Erlangen, Germany.
Tamse R; Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg, Waldstrasse 1, 91054, Erlangen, Germany.
Mueller SK; Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg, Waldstrasse 1, 91054, Erlangen, Germany.
Koch M; Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg, Waldstrasse 1, 91054, Erlangen, Germany.
Gostian AO; Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg, Waldstrasse 1, 91054, Erlangen, Germany.
Iro H; Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg, Waldstrasse 1, 91054, Erlangen, Germany.
Scherl C; Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich Alexander University of Erlangen-Nuremberg, Waldstrasse 1, 91054, Erlangen, Germany.
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Źródło :
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2021 May; Vol. 278 (5), pp. 1567-1575. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
Fibrinolytic Agents*/therapeutic use
Heparin, Low-Molecular-Weight*/therapeutic use
Anticoagulants/therapeutic use ; Heparin ; Humans ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Administering DVT Prophylaxis Sooner Than 48 Hours Does Not Increase Failure of Nonoperative Management of High-Grade (Grades III-V) Splenic Injuries.
Autorzy :
Griffard J; 21823 University of Tennessee Medical Center Knoxville, Knoxville, TN, USA.
Sappington B; 21823 University of Tennessee Medical Center Knoxville, Knoxville, TN, USA.
Griffard M; 21823 University of Tennessee Medical Center Knoxville, Knoxville, TN, USA.
Bollig R; 21823 University of Tennessee Medical Center Knoxville, Knoxville, TN, USA.
McMillen J; 21823 University of Tennessee Medical Center Knoxville, Knoxville, TN, USA.
McKinney A; 21823 University of Tennessee Medical Center Knoxville, Knoxville, TN, USA.
Smith L; 21823 University of Tennessee Medical Center Knoxville, Knoxville, TN, USA.
Daley B; 21823 University of Tennessee Medical Center Knoxville, Knoxville, TN, USA.
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Źródło :
The American surgeon [Am Surg] 2021 Apr; Vol. 87 (4), pp. 527-531. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article
MeSH Terms :
Treatment Failure*
Abdominal Injuries/*therapy
Anticoagulants/*therapeutic use
Heparin/*therapeutic use
Spleen/*injuries
Venous Thrombosis/*prevention & control
Adult ; Chemoprevention ; Female ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Injury Severity Score ; Male ; Prospective Studies ; Time Factors
Czasopismo naukowe
Tytuł :
Heparins as cancer therapy: in theory, they should have worked.
Autorzy :
Posch F; Division of Oncology, Department of Internal Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria. Electronic address: .
Hatzl S; Division of Haematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Ay C; Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Comprehensive Cancer Centre Vienna, Vienna, Austria.
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Źródło :
The Lancet. Haematology [Lancet Haematol] 2020 Oct; Vol. 7 (10), pp. e703-e704.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Heparin*
Neoplasms*
Heparin, Low-Molecular-Weight ; Humans
Czasopismo naukowe
Tytuł :
Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.
Autorzy :
Tree JA; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Turnbull JE; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Liverpool, UK.; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Buttigieg KR; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Elmore MJ; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Coombes N; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Hogwood J; Haemostasis Section, Biotherapeutics, National Institute for Biological Standards and Control (NIBSC), Potters Bar, UK.
Mycroft-West CJ; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Newcastle-Under-Lyme, UK.
Lima MA; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Newcastle-Under-Lyme, UK.
Skidmore MA; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Newcastle-Under-Lyme, UK.
Karlsson R; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Chen YH; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Yang Z; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Spalluto CM; Department of Respiratory Medicine, University of Southampton, Southampton, UK.
Staples KJ; Department of Respiratory Medicine, University of Southampton, Southampton, UK.
Yates EA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, Liverpool, UK.
Gray E; Haemostasis Section, Biotherapeutics, National Institute for Biological Standards and Control (NIBSC), Potters Bar, UK.; Sackler Institute of Pulmonary Pharmacology, King's College London, London, UK.
Singh D; Medicines Evaluation Unit, University of Manchester, Manchester University Hospital NHS Foundation Trust, Manchester, UK.
Wilkinson T; Department of Respiratory Medicine, University of Southampton, Southampton, UK.
Page CP; Sackler Institute of Pulmonary Pharmacology, King's College London, London, UK.
Carroll MW; National Infection Service, Public Health England, Porton Down, Salisbury, UK.; Nuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2021 Feb; Vol. 178 (3), pp. 626-635. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Heparin/*pharmacology
SARS-CoV-2/*growth & development
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/pharmacology ; COVID-19/drug therapy ; Chlorocebus aethiops ; Heparin/metabolism ; Heparin/therapeutic use ; Heparin, Low-Molecular-Weight/pharmacology ; Protein Binding/drug effects ; Spike Glycoprotein, Coronavirus/metabolism ; Viral Plaque Assay
Czasopismo naukowe
Tytuł :
Andexanet Alfa, the Possible Alternative to Protamine for Reversal of Unfractionated Heparin.
Autorzy :
Maneno JN; College of Pharmacy, Belmont University, Nashville, TN, USA.
Ness GL; College of Pharmacy, Belmont University, Nashville, TN, USA.
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Źródło :
The Annals of pharmacotherapy [Ann Pharmacother] 2021 Feb; Vol. 55 (2), pp. 261-264. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Blood Coagulation/*drug effects
Factor Xa/*therapeutic use
Heparin Antagonists/*therapeutic use
Protamines/*therapeutic use
Recombinant Proteins/*therapeutic use
Anticoagulants/adverse effects ; Blood Coagulation Tests ; Factor Xa/administration & dosage ; Factor Xa/adverse effects ; Hemorrhage/chemically induced ; Hemorrhage/prevention & control ; Heparin/adverse effects ; Heparin Antagonists/administration & dosage ; Heparin Antagonists/adverse effects ; Heparin Antagonists/pharmacology ; Humans ; Protamines/administration & dosage ; Protamines/adverse effects ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/adverse effects
Czasopismo naukowe
Tytuł :
Editor's Choice - Protamine Reduces Serious Bleeding Complications Associated with Carotid Endarterectomy in Asymptomatic Patients without Increasing the Risk of Stroke, Myocardial Infarction, or Death in a Large National Analysis.
Autorzy :
Stone DH; Section of Vascular Surgery, Dartmouth-Hitchcock Medical Centre, Lebanon, NH, USA. Electronic address: .
Giles KA; Division of Vascular Surgery & Endovascular Therapy, University of Florida, Gainesville, FL, USA.
Kubilis P; Division of Vascular Surgery & Endovascular Therapy, University of Florida, Gainesville, FL, USA.
Suckow BD; Section of Vascular Surgery, Dartmouth-Hitchcock Medical Centre, Lebanon, NH, USA.
Goodney PP; Section of Vascular Surgery, Dartmouth-Hitchcock Medical Centre, Lebanon, NH, USA; The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon, NH, USA.
Huber TS; Division of Vascular Surgery & Endovascular Therapy, University of Florida, Gainesville, FL, USA.
Powell RJ; Section of Vascular Surgery, Dartmouth-Hitchcock Medical Centre, Lebanon, NH, USA.
Cronenwett JL; Section of Vascular Surgery, Dartmouth-Hitchcock Medical Centre, Lebanon, NH, USA.
Scali ST; Division of Vascular Surgery & Endovascular Therapy, University of Florida, Gainesville, FL, USA.
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Źródło :
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2020 Dec; Vol. 60 (6), pp. 800-807. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article
MeSH Terms :
Endarterectomy, Carotid/*adverse effects
Heparin Antagonists/*therapeutic use
Postoperative Hemorrhage/*prevention & control
Protamines/*therapeutic use
Reoperation/*statistics & numerical data
Aged ; Anticoagulants/adverse effects ; Asymptomatic Diseases ; Blood Loss, Surgical/prevention & control ; Elective Surgical Procedures ; Female ; Heparin/adverse effects ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Myocardial Infarction/epidemiology ; Postoperative Hemorrhage/etiology ; Postoperative Hemorrhage/surgery ; Registries ; Stroke/epidemiology ; United States/epidemiology
Czasopismo naukowe
Tytuł :
Discovery of exolytic heparinases and their catalytic mechanism and potential application.
Autorzy :
Zhang Q; National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China.
Cao HY; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.; College of Marine Life Sciences, and Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, China.; Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
Wei L; National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China.
Lu D; National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China.
Du M; National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China.
Yuan M; National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China.
Shi D; National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China.
Chen X; Tiandong Pharma, Dongying, China.
Wang P; College of Marine Life Sciences, and Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, China.; Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
Chen XL; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.; Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
Chi L; National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China.
Zhang YZ; College of Marine Life Sciences, and Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao, China. .; Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China. .
Li F; National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 24; Vol. 12 (1), pp. 1263. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Heparin Lyase/*metabolism
Catalysis ; Heparin/metabolism ; Static Electricity
Czasopismo naukowe
Tytuł :
Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients.
Autorzy :
Buijsers B; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Yanginlar C; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
Maciej-Hulme ML; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
de Mast Q; Department of Internal Medicine, Radboud university medical center, Nijmegen, The Netherlands.
van der Vlag J; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.
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Źródło :
EBioMedicine [EBioMedicine] 2020 Sep; Vol. 59, pp. 102969. Date of Electronic Publication: 2020 Aug 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anti-Inflammatory Agents/*therapeutic use
Coronavirus Infections/*drug therapy
Heparin/*therapeutic use
Pneumonia, Viral/*drug therapy
Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/pharmacology ; Betacoronavirus/isolation & purification ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Glucuronidase/antagonists & inhibitors ; Glucuronidase/metabolism ; Heparin/metabolism ; Heparin/pharmacology ; Heparin, Low-Molecular-Weight/metabolism ; Heparin, Low-Molecular-Weight/pharmacology ; Heparin, Low-Molecular-Weight/therapeutic use ; Histones/blood ; Histones/metabolism ; Humans ; Pandemics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Comprehensive analysis of heparinase derived heparin-products using two-dimensional liquid chromatography coupled with mass spectrometry.
Autorzy :
Chen L; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China.
Ouyang Y; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China.
Yan N; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China.
Guo Y; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China.
Yi L; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China.
Sun Y; The fourth people's Hospital of Jinan City, Shandong Province, 250031, China.
Liu D; The fourth people's Hospital of Jinan City, Shandong Province, 250031, China.
Zhang Z; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Apr 26; Vol. 1643, pp. 462049. Date of Electronic Publication: 2021 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Heparin/*analysis
Heparin Lyase/*metabolism
Mass Spectrometry/*methods
Chromatography, Gel ; Chromatography, Ion Exchange ; Chromatography, Liquid ; Disaccharides/chemistry ; Heparin/chemistry ; Oligosaccharides/chemistry
Czasopismo naukowe
Tytuł :
Evaluating prophylactic heparin in ambulatory patients with solid tumours: a systematic review and individual participant data meta-analysis.
Autorzy :
Schünemann HJ; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address: .
Ventresca M; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Crowther M; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Briel M; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Department of Clinical Research, Basel Institute for Clinical Epidemiology and Biostatistics, University of Basel and University Hospital Basel, Basel, Switzerland.
Zhou Q; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Noble S; Marie Curie Palliative Care Research Centre, Cardiff University, Cardiff, Wales, UK.
Macbeth F; Centre for Trials Research, College of Biomedical & Life Sciences, Cardiff University, Cardiff, Wales, UK.
Griffiths G; Centre for Trials Research, College of Biomedical & Life Sciences, Cardiff University, Cardiff, Wales, UK; Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.
Garcia D; Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Lyman GH; Hutchinson Institute for Cancer Outcomes Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; University of Washington School of Medicine, Seattle, WA, USA.
Di Nisio M; Department of Medicine and Ageing Sciences, University G D'Annunzio, Chieti-Pescara, Italy; Department of Vascular Medicine, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, Netherlands.
Iorio A; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Division of Haematology, Department of Medicine, McMaster University, Hamilton, ON, Canada; Division of Haematology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Mbuagbaw L; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare, Hamilton, ON, Canada.
Neumann I; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Department of Internal Medicine, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
van Es N; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Department of Vascular Medicine, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, Netherlands.
Brouwers M; Faculty of Medicine, School of Epidemiology and Public Heath, University of Ottawa, Ottawa, ON, Canada.
Guyatt G; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Streiff MB; Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marcucci M; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Baldeh T; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Florez ID; Michael G DeGroote Cochrane Canada and McGRADE Centres, Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Department of Paediatrics, Universidad de Antioquia, Medellin, Colombia.
Alma OG; Department of Statistics, Mugla Sıtkı Koçman University, Mugla, Turkey.
Solh Z; Transfusion Medicine Section, Department of Pathology & Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Bossuyt PM; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, Netherlands.
Kahale LA; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
Ageno W; Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Bozas G; Academic Department of Medical Oncology, Castle Hill Hospital, Cottingham, Hull University Teaching Hospitals NHS Trust, Hull, UK.
Büller HR; Department of Vascular Medicine, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, Netherlands.
Lebeau B; Service de Pneumologie, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France.
Lecumberri R; Haematology Service, University Clinic of Navarra, Pamplona, Spain.
Loprinzi C; Divisions of Cardiology and Medical Oncology, Mayo Clinic, Rochester, MN, USA.
McBane R; Divisions of Vascular Medicine and Hematology, Mayo Clinic, Rochester, MN, USA.
Sideras K; Divisions of Medical Oncology and Hematology, Mayo Clinic, Rochester, MN, USA.
Maraveyas A; Division of Cancer, Hull York Medical School, University of Hull, Hull, UK.
Pelzer U; Division of Haematology, Oncology and Tumour Immunology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt Universität - Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Perry J; Ontario Clinical Oncology Group and Department of Oncology, McMaster University, Hamilton, ON, Canada; Division of Neurology, Sunnybrook Health Science Centre, Toronto, ON, Canada.
Klerk C; Department of Internal Medicine, Dijklanderziekenhuis, Hoorn, Netherlands.
Agnelli G; Internal and Cardiovascular Medicine-Stroke Unit, University of Perugia, Perugia, Italy.
Akl EA; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
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Źródło :
The Lancet. Haematology [Lancet Haematol] 2020 Oct; Vol. 7 (10), pp. e746-e755.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Anticoagulants/*therapeutic use
Heparin/*therapeutic use
Neoplasms/*complications
Venous Thromboembolism/*etiology
Venous Thromboembolism/*prevention & control
Anticoagulants/adverse effects ; Hemorrhage/chemically induced ; Heparin/adverse effects ; Heparin, Low-Molecular-Weight/adverse effects ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Survival Analysis
Czasopismo naukowe
Tytuł :
A 0.6-protamine/heparin ratio in cardiac surgery is associated with decreased transfusion of blood products.
Autorzy :
Goedhart ALM; Department of Anaesthesiology and Intensive Care, Amphia Hospital, Breda, Netherlands.
Gerritse BM; Department of Anaesthesiology and Intensive Care, Amphia Hospital, Breda, Netherlands.
Rettig TCD; Department of Anaesthesiology and Intensive Care, Amphia Hospital, Breda, Netherlands.
van Geldorp MWA; Department of Cardiothoracic Surgery, Amphia Hospital, Breda, Netherlands.
Bramer S; Department of Cardiothoracic Surgery, Amphia Hospital, Breda, Netherlands.
van der Meer NJM; Department of Anaesthesiology and Intensive Care, Amphia Hospital, Breda, Netherlands.
Boonman-de Winter LJ; Department of Research and Epidemiology, Amphia Hospital, Breda, Netherlands.
Scohy TV; Department of Anaesthesiology and Intensive Care, Amphia Hospital, Breda, Netherlands.
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Źródło :
Interactive cardiovascular and thoracic surgery [Interact Cardiovasc Thorac Surg] 2020 Sep 01; Vol. 31 (3), pp. 391-397.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiac Surgical Procedures*
Blood Component Transfusion/*trends
Heparin/*pharmacology
Protamines/*pharmacology
Aged ; Anticoagulants/pharmacology ; Blood Coagulation/drug effects ; Blood Loss, Surgical/prevention & control ; Female ; Heparin Antagonists/pharmacology ; Humans ; Male ; Postoperative Hemorrhage/prevention & control
Czasopismo naukowe
Tytuł :
Mid-term Clinical Outcomes of Immediate Protamine Use Following Elective Percutaneous Coronary Interventions.
Autorzy :
Kubota M; Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Sakakura K; Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Yamamoto K; Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Taniguchi Y; Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Tsukui T; Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Seguchi M; Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Wada H; Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Momomura SI; Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Fujita H; Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
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Źródło :
International heart journal [Int Heart J] 2020 Sep 29; Vol. 61 (5), pp. 865-871. Date of Electronic Publication: 2020 Sep 12.
Typ publikacji :
Journal Article
MeSH Terms :
Coronary Stenosis/*surgery
Heparin Antagonists/*therapeutic use
Percutaneous Coronary Intervention/*methods
Postoperative Complications/*epidemiology
Postoperative Hemorrhage/*prevention & control
Protamines/*therapeutic use
Thrombosis/*epidemiology
Aged ; Aged, 80 and over ; Anticoagulants/adverse effects ; Case-Control Studies ; Coronary Stenosis/epidemiology ; Elective Surgical Procedures/methods ; Female ; Heparin/adverse effects ; Humans ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Myocardial Revascularization/statistics & numerical data ; Postoperative Complications/chemically induced ; Postoperative Hemorrhage/chemically induced ; Proportional Hazards Models ; Renal Dialysis ; Retrospective Studies ; Stents ; Thrombosis/chemically induced ; Vascular Calcification/epidemiology
Czasopismo naukowe
Tytuł :
Multi-centre, three arm, randomized controlled trial on the use of methylprednisolone and unfractionated heparin in critically ill ventilated patients with pneumonia from SARS-CoV-2 infection: A structured summary of a study protocol for a randomised controlled trial.
Autorzy :
Busani S; Anaesthesia and Intensive Care Unit, Terapia Intensiva Polivalente, Policlinico di Modena, Azienda Ospedaliero-Universitaria di Modena, Ospedale Policlinico, Via del Pozzo, 71, 41124, Modena, Italy. .
Tosi M; Anaesthesia and Intensive Care Unit, Terapia Intensiva Polivalente, Policlinico di Modena, Azienda Ospedaliero-Universitaria di Modena, Ospedale Policlinico, Via del Pozzo, 71, 41124, Modena, Italy.
Mighali P; Servizio Formazione, Ricerca e Innovazione, Azienda Ospedaliero-Universitaria di Modena, Ospedale Policlinico, Modena, Italy.
Vandelli P; Servizio Formazione, Ricerca e Innovazione, Azienda Ospedaliero-Universitaria di Modena, Ospedale Policlinico, Modena, Italy.
D'Amico R; Cattedra di Statistica Medica, Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Modena, Italy.
Marietta M; Haematology Unit, Azienda Ospedaliero-Universitaria di Modena, Ospedale Policlinico, Modena, Italy.
Forfori F; Dipartimento di Anestesia e Terapia Intensiva, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
Donati A; Anaesthesia and Intensive Care Unit, Department of Biomedical Sciences and Public Health, Università Politecnica delle Marche, Torrette di Ancona, Italy.
Cinnella G; Department of Anesthesia and Intensive Care, O.O. Riuniti Hospital, University of Foggia, Foggia, Italy.
De Monte A; Anesthesiology and Intensive Care 1, Department of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Integrata-Udine, Udine, Italy.
Pasero D; Department of Medical, Surgical and Experimental Science, University of Sassari, Sassari, Italy.
Bellani G; Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy.
Tascini C; Clinica di Malattie Infettive, Azienda Sanitaria Universitaria Friuli centrale, Udine, Italy.
Foti G; Department of Emergency Medicine, San Gerardo Hospital, Monza, Italy.; Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
Ranieri M; Anesthesia and Intensive Care Medicine, University Hospital of Bologna Sant'Orsola, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Girardis M; Anaesthesia and Intensive Care Unit, Terapia Intensiva Polivalente, Policlinico di Modena, Azienda Ospedaliero-Universitaria di Modena, Ospedale Policlinico, Via del Pozzo, 71, 41124, Modena, Italy.
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Źródło :
Trials [Trials] 2020 Aug 17; Vol. 21 (1), pp. 724. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Clinical Trial Protocol; Letter; Multicenter Study
MeSH Terms :
Betacoronavirus*
Critical Illness*
Randomized Controlled Trials as Topic*
Respiration, Artificial*
Coronavirus Infections/*drug therapy
Heparin/*administration & dosage
Methylprednisolone/*administration & dosage
Pneumonia, Viral/*drug therapy
Adult ; COVID-19 ; Heparin/adverse effects ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Methylprednisolone/adverse effects ; Pandemics ; Partial Thromboplastin Time ; SARS-CoV-2
Raport
Tytuł :
Sevuparin for the treatment of acute pain crisis in patients with sickle cell disease: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
Autorzy :
Biemond BJ; Department of Hematology, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam, Netherlands. Electronic address: .
Tombak A; Department of Hematology, Faculty of Medicine, Mersin University, Mersin, Turkey.
Kilinc Y; Medical Faculty, Cukurova University, Adana, Turkey.
Al-Khabori M; Department of Pediatric Hematology, Sultan Qaboos University Hospital, Muscat, Oman.
Abboud M; Medical Center, American University of Beirut, Beirut, Lebanon.
Nafea M; Salmaniya Medical Complex, Manama, Bahrian.
Inati A; Lebanese American University, Byblos and Nini Hospital, Tripoli, Lebanon.
Wali Y; Department of Pediatric Hematology, Sultan Qaboos University Hospital, Muscat, Oman.
Kristensen J; Modus Therapeutics, Stockholm, Sweden.
Kowalski J; Modus Therapeutics, Stockholm, Sweden.
Donnelly E; Modus Therapeutics, Stockholm, Sweden.
Ohd J; Modus Therapeutics, Stockholm, Sweden.
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Corporate Authors :
TVOC01 Investigators Group
Źródło :
The Lancet. Haematology [Lancet Haematol] 2021 May; Vol. 8 (5), pp. e334-e343.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Acute Pain/*drug therapy
Anemia, Sickle Cell/*pathology
Heparin/*analogs & derivatives
Acute Pain/complications ; Adolescent ; Adult ; Anemia, Sickle Cell/complications ; Child ; Female ; Fever/etiology ; Hemoglobins/analysis ; Heparin/adverse effects ; Heparin/therapeutic use ; Humans ; Male ; Partial Thromboplastin Time ; Placebo Effect ; Proportional Hazards Models ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Double-Network Heparin Dynamic Hydrogels: Dynagels as Anti-bacterial 3D Cell Culture Scaffolds.
Autorzy :
Cui H; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, P. R. China.
Wang Q; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, P. R. China.
Zhang Y; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, P. R. China.
Barboiu M; Institut Europeen des Membranes, Adaptive Supramolecular Nanosystems Group, University of Montpellier, ENSCM-CNRS, Place E. Bataillon CC047, 34095, Montpellier, France.
Zhang Y; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, P. R. China.
Chen J; Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, P. R. China.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Apr 26; Vol. 27 (24), pp. 7080-7084. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Heparin*
Hydrogels*
Cell Culture Techniques
Czasopismo naukowe
Tytuł :
Double-edged sword effect of anticoagulant in COVID-19 infection.
Autorzy :
Ohn MH; Cardiology Department, Lewisham Hospital NHS Trust, London, UK.
Ng JR; Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.
Ohn KM; Surgical Department, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia .
Luen NP; Emergency Department, Miri Hospital, Miri, Sarawak, Malaysia.
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Źródło :
BMJ case reports [BMJ Case Rep] 2021 Mar 22; Vol. 14 (3). Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Retroperitoneal Space*
Anticoagulants/*adverse effects
COVID-19/*drug therapy
Hemorrhage/*chemically induced
Heparin/*adverse effects
Anticoagulants/administration & dosage ; Anticoagulants/therapeutic use ; COVID-19/complications ; COVID-19/diagnostic imaging ; Drug Administration Schedule ; Fatal Outcome ; Female ; Heparin/administration & dosage ; Heparin/therapeutic use ; Humans ; Middle Aged ; Radiography ; SARS-CoV-2 ; Tomography, X-Ray Computed ; Venous Thromboembolism/prevention & control
Czasopismo naukowe
Tytuł :
Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin.
Autorzy :
Schnitzler A; Universität zu Köln, Department für Chemie, Institut für Biochemie, Zülpicher Straße 47, D-50674 Köln, Germany.
Niefind K; Universität zu Köln, Department für Chemie, Institut für Biochemie, Zülpicher Straße 47, D-50674 Köln, Germany. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 15; Vol. 214, pp. 113223. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Casein Kinase II/*antagonists & inhibitors
Heparin/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Casein Kinase II/isolation & purification ; Casein Kinase II/metabolism ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Heparin/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Management of anticoagulated patients in dentoalveolar surgery: a retrospective study comparing bridging with heparin versus unpaused vitamin K antagonist medication.
Autorzy :
Buchbender M; Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Glückstrasse 11, 91054, Erlangen, Germany. .
Rößler F; Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Glückstrasse 11, 91054, Erlangen, Germany.
Kesting MR; Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Glückstrasse 11, 91054, Erlangen, Germany.
Frohwitter G; Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Glückstrasse 11, 91054, Erlangen, Germany.
Adler W; Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Rau A; Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-University Erlangen-Nuremberg, Glückstrasse 11, 91054, Erlangen, Germany.
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Źródło :
BMC oral health [BMC Oral Health] 2021 Mar 05; Vol. 21 (1), pp. 96. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Heparin*
Vitamin K*
Anticoagulants/adverse effects ; Humans ; Postoperative Hemorrhage/epidemiology ; Postoperative Hemorrhage/prevention & control ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Nebulised heparin for patients with or at risk of acute respiratory distress syndrome: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial.
Autorzy :
Dixon B; Department of Critical Care Medicine, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia. Electronic address: .
Smith RJ; Department of Critical Care Medicine, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia.
Campbell DJ; Molecular Cardiology Research Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia; Department of Medicine, The University of Melbourne and St Vincent's Hospital Melbourne, Melbourne, VIC, Australia.
Moran JL; Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville, SA, Australia.
Doig GS; Northern Clinical School Intensive Care Research Unit, University of Sydney, St Leonards, NSW, Australia.
Rechnitzer T; Intensive Care Unit, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
MacIsaac CM; Intensive Care Unit, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
Simpson N; Intensive Care Unit, University Hospital Geelong, Geelong, VIC, Australia.
van Haren FMP; Intensive Care Unit, The Canberra Hospital, Woden, ACT, Australia; Medical School, Australian National University, Canberra, ACT, Australia.
Ghosh AN; Intensive Care Unit, Northern Hospital, Epping, VIC, Australia.
Gupta S; Intensive Care Unit, Frankston Hospital, Frankston, VIC, Australia.
Broadfield EJC; Intensive Care Unit, Bendigo Hospital, Bendigo, VIC, Australia.
Crozier TME; Intensive Care Unit, Monash Medical Centre, Clayton, VIC, Australia.
French C; Intensive Care Unit, Footscray and Sunshine Hospitals, Western Health, Sunshine, VIC, Australia.
Santamaria JD; Department of Critical Care Medicine, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia.
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Corporate Authors :
CHARLI Study Group
Źródło :
The Lancet. Respiratory medicine [Lancet Respir Med] 2021 Apr; Vol. 9 (4), pp. 360-372. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Critical Care/*methods
Heparin/*administration & dosage
Respiration, Artificial/*adverse effects
Respiratory Distress Syndrome/*epidemiology
Activities of Daily Living ; Administration, Inhalation ; Adult ; Aged ; Australia/epidemiology ; Double-Blind Method ; Female ; Hemoptysis/chemically induced ; Hemoptysis/epidemiology ; Heparin/adverse effects ; Hospital Mortality ; Humans ; Hypoxia/chemically induced ; Hypoxia/epidemiology ; Incidence ; Male ; Middle Aged ; Nebulizers and Vaporizers ; Placebos/administration & dosage ; Placebos/adverse effects ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/prevention & control ; Self Report/statistics & numerical data ; Severity of Illness Index ; Survivors/statistics & numerical data ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
An unexpected case of recurrence of pulmonary embolism in a patient recovered from COVID19 in full regimen dose of direct oral anticoagulant drug.
Autorzy :
D'Elia E; Cardiovascular Department, Hospital Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy. .
Gori M; Cardiovascular Department, Hospital Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy.
Grosu A; Cardiovascular Department, Hospital Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy.
Iorio A; Cardiovascular Department, Hospital Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy.
Lorini FL; Cardiovascular Department, Hospital Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy.
Falanga A; Cardiovascular Department, Hospital Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy.; Department of Medicine and Surgery, University of Milan, Milan, Italy.
Di Marco F; Cardiovascular Department, Hospital Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy.; Department of Health Sciences, University of Milan, Milan, Italy.
Senni M; Cardiovascular Department, Hospital Papa Giovanni XXIII, Piazza OMS 1, Bergamo, Italy.
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Źródło :
BMC pulmonary medicine [BMC Pulm Med] 2021 Mar 24; Vol. 21 (1), pp. 102. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Anticoagulants/*administration & dosage
COVID-19/*complications
Dabigatran/*administration & dosage
Heparin/*administration & dosage
Pulmonary Embolism/*prevention & control
Pulmonary Embolism/*virology
Warfarin/*administration & dosage
Administration, Oral ; Anticoagulants/therapeutic use ; Dabigatran/therapeutic use ; Drug Therapy, Combination ; Heparin/therapeutic use ; Humans ; Male ; Middle Aged ; Pulmonary Embolism/drug therapy ; Recurrence ; Warfarin/therapeutic use
Czasopismo naukowe

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