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Tytuł :
A Small Molecule, ACAi-028, with Anti-HIV-1 Activity Targets a Novel Hydrophobic Pocket on HIV-1 Capsid.
Autorzy :
Chia T; Department of Hematology, Rheumatology, and Infectious Diseases, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto Universitygrid.274841.c, Kumamoto, Japan.
Nakamura T; Department of Hematology, Rheumatology, and Infectious Diseases, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto Universitygrid.274841.c, Kumamoto, Japan.
Amano M; Department of Hematology, Rheumatology, and Infectious Diseases, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto Universitygrid.274841.c, Kumamoto, Japan.
Takamune N; Kumamoto Innovative Development Organization, Kumamoto Universitygrid.274841.c, Kumamoto, Japan.
Matsuoka M; Department of Hematology, Rheumatology, and Infectious Diseases, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto Universitygrid.274841.c, Kumamoto, Japan.
Nakata H; Department of Hematology, Rheumatology, and Infectious Diseases, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto Universitygrid.274841.c, Kumamoto, Japan.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 Sep 17; Vol. 65 (10), pp. e0103921. Date of Electronic Publication: 2021 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents*/pharmacology
HIV-1*
Capsid ; Capsid Proteins/genetics ; Humans ; Phenylalanine/pharmacology ; Virus Replication
Czasopismo naukowe
Tytuł :
Identification of key immune regulatory genes in HIV-1 progression.
Autorzy :
Hossain SMM; Department of Computer Science and Engineering, Aliah University, Kolkata 700160, India; Department of Computer Science and Engineering, University of Kalyani, Kalyani 741235, India. Electronic address: .
Khatun L; Department of Computer Science and Engineering, University of Kalyani, Kalyani 741235, India.
Ray S; Department of Computer Science and Engineering, Aliah University, Kolkata 700160, India. Electronic address: .
Mukhopadhyay A; Department of Computer Science and Engineering, University of Kalyani, Kalyani 741235, India. Electronic address: .
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Źródło :
Gene [Gene] 2021 Aug 05; Vol. 792, pp. 145735. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, CD/*genetics
Chemokines/*genetics
HIV Infections/*genetics
HIV-1/*pathogenicity
Host-Pathogen Interactions/*genetics
Human Immunodeficiency Virus Proteins/*genetics
Acute Disease ; Antigens, CD/classification ; Antigens, CD/immunology ; Chemokines/classification ; Chemokines/immunology ; Chronic Disease ; Datasets as Topic ; Disease Progression ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Ontology ; Gene Regulatory Networks ; HIV Infections/immunology ; HIV Infections/pathology ; HIV Infections/virology ; HIV-1/growth & development ; Host-Pathogen Interactions/immunology ; Human Immunodeficiency Virus Proteins/classification ; Human Immunodeficiency Virus Proteins/immunology ; Humans ; Microarray Analysis ; Molecular Sequence Annotation ; Protein Binding ; Signal Transduction
Czasopismo naukowe
Tytuł :
Design and evaluation of novel piperidine HIV-1 protease inhibitors with potency against DRV-resistant variants.
Autorzy :
Zhu M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
Zhou H; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
Ma L; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
Dong B; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
Zhou J; Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, Jinhua, 321004, China.
Zhang G; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
Wang M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.
Wang J; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China. Electronic address: .
Cen S; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China. Electronic address: .
Wang Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Aug 05; Vol. 220, pp. 113450. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Anti-HIV Agents/*pharmacology
HIV Protease/*metabolism
HIV Protease Inhibitors/*pharmacology
HIV-1/*drug effects
Piperidines/*pharmacology
Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/chemistry ; Darunavir/pharmacology ; Dose-Response Relationship, Drug ; Drug Resistance, Viral/drug effects ; HIV Protease Inhibitors/chemical synthesis ; HIV Protease Inhibitors/chemistry ; HIV-1/enzymology ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Piperidines/chemical synthesis ; Piperidines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Membraneless organelles restructured and built by pandemic viruses: HIV-1 and SARS-CoV-2.
Autorzy :
Scoca V; Advanced Molecular Virology and Retroviral Dynamics Group, Department of Virology, Pasteur Institute, Paris, France.; BioSPC Doctoral School, Universitè de Paris, Paris, France.
Di Nunzio F; Advanced Molecular Virology and Retroviral Dynamics Group, Department of Virology, Pasteur Institute, Paris, France.
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Źródło :
Journal of molecular cell biology [J Mol Cell Biol] 2021 Aug 04; Vol. 13 (4), pp. 259-268.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
HIV-1/*physiology
Organelles/*metabolism
SARS-CoV-2/*physiology
COVID-19/pathology ; COVID-19/virology ; HIV Infections/pathology ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/isolation & purification ; Host-Pathogen Interactions ; Humans ; Nucleocapsid Proteins/metabolism ; RNA, Viral/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Virus Replication
Czasopismo naukowe
Tytuł :
Management of HIV-2 resistance to antiretroviral therapy in a HIV-1/HIV-2/HBV co-infected patient.
Autorzy :
Cardoso M; Serviço de Doenças Infeciosas e Medicina Tropical, Hospital De Egas Moniz - Centro Hospitalar Lisboa Ocidental, 1349-019, Lisbon, Portugal. .
Vasconcelos J; Serviço de Doenças Infeciosas e Medicina Tropical, Hospital De Egas Moniz - Centro Hospitalar Lisboa Ocidental, 1349-019, Lisbon, Portugal.
Baptista T; Serviço de Doenças Infeciosas e Medicina Tropical, Hospital De Egas Moniz - Centro Hospitalar Lisboa Ocidental, 1349-019, Lisbon, Portugal.
Diogo I; Laboratório de Biologia Molecular, LMCBM, SPC.HEM - Centro Hospitalar Lisboa Ocidental, 1349-019, Lisbon, Portugal.
Gonçalves F; Laboratório de Biologia Molecular, LMCBM, SPC.HEM - Centro Hospitalar Lisboa Ocidental, 1349-019, Lisbon, Portugal.
Mansinho K; Serviço de Doenças Infeciosas e Medicina Tropical, Hospital De Egas Moniz - Centro Hospitalar Lisboa Ocidental, 1349-019, Lisbon, Portugal.
Gomes P; Laboratório de Biologia Molecular, LMCBM, SPC.HEM - Centro Hospitalar Lisboa Ocidental, 1349-019, Lisbon, Portugal.; Centro de Investigação Interdisciplinar Egas Moniz, CiiEM, ISCSEM, 2829-511, Almada, Portugal.
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Źródło :
AIDS research and therapy [AIDS Res Ther] 2021 Oct 12; Vol. 18 (1), pp. 69. Date of Electronic Publication: 2021 Oct 12.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Coinfection*/drug therapy
HIV Infections*/drug therapy
HIV-1*/genetics
HIV-2/genetics ; Hepatitis B virus/genetics ; Humans ; Male
Czasopismo naukowe
Tytuł :
Dynamics of the Decay of Human Immunodeficiency Virus (HIV) RNA and Distribution of Bictegravir in the Genital Tract and Rectum in Antiretroviral-naive Adults Living With HIV-1 Treated With Bictegravir/Emtricitabine/Tenofovir Alafenamide (Spanish HIV/AIDS Research Network, PreEC/RIS 58).
Autorzy :
Imaz A; Human Immunodeficiency Virus (HIV) and Sexually Transmitted Infection (STI) Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Tiraboschi JM; Human Immunodeficiency Virus (HIV) and Sexually Transmitted Infection (STI) Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Niubó J; Department of Microbiology, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Martinez-Picado J; IrsiCaixa AIDS Research Institute, Badalona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.; University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.
Cottrell ML; Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Domingo P; Department of Infectious Diseases, Santa Creu i Sant Pau Hospital, Barcelona, Spain.
Chivite I; Department of Internal Medicine, Sant Joan Despí Moisès Broggi Hospital, Sant Joan Despí, Barcelona, Spain.
Negredo E; Lluita Contra la Sida Foundation, Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain.
Schauer A; Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Van Horne B; Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Morenilla S; Human Immunodeficiency Virus (HIV) and Sexually Transmitted Infection (STI) Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Urrea V; IrsiCaixa AIDS Research Institute, Badalona, Spain.
Silva-Klug A; Human Immunodeficiency Virus (HIV) and Sexually Transmitted Infection (STI) Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Scévola S; Human Immunodeficiency Virus (HIV) and Sexually Transmitted Infection (STI) Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Garcia B; Human Immunodeficiency Virus (HIV) and Sexually Transmitted Infection (STI) Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Kashuba ADM; Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Podzamczer D; Human Immunodeficiency Virus (HIV) and Sexually Transmitted Infection (STI) Unit, Department of Infectious Diseases, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
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Źródło :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Oct 05; Vol. 73 (7), pp. e1991-e1999.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents*/therapeutic use
HIV Infections*/drug therapy
HIV-1*/genetics
Adult ; Alanine ; Amides ; Emtricitabine/therapeutic use ; Female ; Genitalia ; Heterocyclic Compounds, 3-Ring ; Humans ; Male ; Piperazines ; Prospective Studies ; Pyridones ; RNA/therapeutic use ; Rectum ; Tenofovir/analogs & derivatives
Czasopismo naukowe
Tytuł :
Drug Resistance Mutations Among South African Children Living With HIV on WHO-recommended ART Regimens.
Autorzy :
Hackett S; US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Teasdale CA; Department of Epidemiology and Biostatistics, CUNY Graduate School of Public Health & Health Policy, New York, USA.; ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Pals S; US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Muttiti A; ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, USA.
Mogashoa M; US Centers for Disease Control and Prevention, Pretoria, South Africa.
Chang J; US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Zeh C; US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Ramos A; US Centers for Disease Control and Prevention, Maputo, Mozambique.
Rivadeneira ED; US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
DeVos J; US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Sleeman K; US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Abrams EJ; ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, USA.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.; Department of Pediatrics, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA.
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Źródło :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Oct 05; Vol. 73 (7), pp. e2217-e2225.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Anti-HIV Agents*/pharmacology
Anti-HIV Agents*/therapeutic use
Drug Resistance, Viral*
HIV Infections*/drug therapy
HIV-1*/drug effects
HIV-1*/genetics
Female ; Humans ; Infectious Disease Transmission, Vertical ; Mutation ; World Health Organization
Czasopismo naukowe
Tytuł :
HIV-1 diagnosis using dried blood spots from patients in Kinshasa, DRC: a tool to detect misdiagnosis and achieve World Health Organization 2030 targets.
Autorzy :
Barquín D; Microbiology Department, Clínica Universidad de Navarra, Pamplona, Spain.
Ndarabu A; Centre Hospitalier Monkole, Kinshasa, Democratic Republic of the Congo.
Carlos S; ISTUN, Institute of Tropical Health, Universidad de Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; Department of Preventive Medicine and Public Health, Universidad de Navarra, Pamplona, Spain.
Fernández-Alonso M; Microbiology Department, Clínica Universidad de Navarra, Pamplona, Spain; ISTUN, Institute of Tropical Health, Universidad de Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
Rubio-Garrido M; HIV-1 Molecular Epidemiology Laboratory, Microbiology and Parasitology Department, University Hospital Ramón y Cajal-IRYCIS and CIBEREsp-RITIP, Madrid, Spain.
Makonda B; Centre Hospitalier Monkole, Kinshasa, Democratic Republic of the Congo.
Holguín Á; HIV-1 Molecular Epidemiology Laboratory, Microbiology and Parasitology Department, University Hospital Ramón y Cajal-IRYCIS and CIBEREsp-RITIP, Madrid, Spain.
Reina G; Microbiology Department, Clínica Universidad de Navarra, Pamplona, Spain; ISTUN, Institute of Tropical Health, Universidad de Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. Electronic address: .
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Źródło :
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Oct; Vol. 111, pp. 253-260. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
HIV Infections*/diagnosis
HIV-1*
Democratic Republic of the Congo ; Diagnostic Errors ; Humans ; Sensitivity and Specificity ; World Health Organization
Czasopismo naukowe
Tytuł :
HIV-1 impact on oral health-related quality of life: a cross-sectional study.
Autorzy :
Rocha Trindade RTVM; Faculty of Dentistry, Department of Oral Biology, Universidade de Lisboa, Lisbon, Portugal.
Marques JROF; Faculty of Dentistry, Department of Oral Biology, Universidade de Lisboa, Lisbon, Portugal.
Veiga MAGD; ABRAÇO, Lisbon, Portugal.
Marques DNDS; Faculty of Dentistry, Department of Oral Biology, Universidade de Lisboa, Lisbon, Portugal.
Mata ADSPD; Faculty of Dentistry, Department of Oral Biology, Universidade de Lisboa, Lisbon, Portugal.
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Źródło :
AIDS care [AIDS Care] 2021 Oct; Vol. 33 (10), pp. 1321-1328. Date of Electronic Publication: 2020 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
HIV Infections*
HIV-1*
Adult ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Oral Health ; Quality of Life ; Surveys and Questionnaires ; Young Adult
Czasopismo naukowe
Tytuł :
Genetic characteristics of HIV-1 CRF06_cpx and CRF56_cpx strains isolated in Guangzhou, China.
Autorzy :
Lan Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou, 510060, China.
Li L; Guangzhou Eighth People's Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou, 510060, China.
Cai W; Guangzhou Eighth People's Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou, 510060, China.
Li J; Guangzhou Eighth People's Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou, 510060, China.
Deng X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou, 510060, China.
Li F; Guangzhou Eighth People's Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou, 510060, China.
Lei C; Guangzhou Eighth People's Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou, 510060, China.
Hu F; Guangzhou Eighth People's Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou, 510060, China. .
Tang X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, 627 Dongfeng East Road, Yuexiu District, Guangzhou, 510060, China. .
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Źródło :
Archives of virology [Arch Virol] 2021 Oct; Vol. 166 (10), pp. 2853-2857. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
HIV Infections/*virology
HIV-1/*genetics
Adult ; China/epidemiology ; Cities/epidemiology ; Drug Resistance, Viral/genetics ; Female ; Genome, Viral/genetics ; Genotype ; HIV Infections/epidemiology ; HIV-1/classification ; HIV-1/isolation & purification ; Humans ; Male ; Mutation ; Phylogeny ; Recombination, Genetic ; pol Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Early ART-initiation and longer ART duration reduces HIV-1 proviral DNA levels in children from the CHER trial.
Autorzy :
Payne H; Institute of Child Health, University College London, London, United Kingdom. .; Department of Paediatrics and Child Health, Family Center for Research With Ubuntu, Stellenbosch University, Cape Town, South Africa. .; Department of Paediatric Infectious Diseases, Imperial College London, Room 235, Medical School Building, Norfolk Place, London, W21PG, United Kingdom. .
Chan MK; MRC Clinical Trials Unit at University College London, London, United Kingdom.
Watters SA; Department of Infection and Immunity, University College London, London, United Kingdom.; Department of Clinical Microbiology and Virology, University College London Hospitals NHS Trust, London, United Kingdom.
Otwombe K; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Hsiao NY; Division of Medical Virology, Department of Pathology, University of Cape Town and National Health Laboratory Service, Cape Town, South Africa.
Babiker A; MRC Clinical Trials Unit at University College London, London, United Kingdom.
Violari A; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Cotton MF; Department of Paediatrics and Child Health, Family Center for Research With Ubuntu, Stellenbosch University, Cape Town, South Africa.
Gibb DM; MRC Clinical Trials Unit at University College London, London, United Kingdom.
Klein NJ; Institute of Child Health, University College London, London, United Kingdom.
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Źródło :
AIDS research and therapy [AIDS Res Ther] 2021 Sep 29; Vol. 18 (1), pp. 63. Date of Electronic Publication: 2021 Sep 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Infections*/drug therapy
HIV-1*/genetics
Child ; DNA, Viral/genetics ; Humans ; Leukocytes, Mononuclear ; Viral Load ; Virus Latency
Czasopismo naukowe
Tytuł :
Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China.
Autorzy :
Wang Y; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, 650223, China.; KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, 199 Renai Road, Wuzhong District, Suzhou, 215000, China.
Chen X; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, 650223, China.; Department of Pathogenic Biology, School of Basic Medical Sciences, Gannan Medical University, Ganzhou, China.
Ye M; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, 650223, China.; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China.
Pang W; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, 650223, China.
Zhang C; Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xiong SD; KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, 199 Renai Road, Wuzhong District, Suzhou, 215000, China. .; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China. .
Zheng YT; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, 650223, China. .; KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, 199 Renai Road, Wuzhong District, Suzhou, 215000, China. .
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Źródło :
BMC infectious diseases [BMC Infect Dis] 2021 Sep 25; Vol. 21 (1), pp. 1001. Date of Electronic Publication: 2021 Sep 25.
Typ publikacji :
Journal Article
MeSH Terms :
Coinfection*/epidemiology
Drug Users*
HIV Infections*/complications
HIV Infections*/epidemiology
HIV-1*/genetics
Hepatitis C*/complications
Hepatitis C*/epidemiology
China/epidemiology ; Genotype ; Hepacivirus/genetics ; Humans ; Phylogeny
Czasopismo naukowe
Tytuł :
Development of a Novel In Vitro Primary Human Monocyte-Derived Macrophage Model To Study Reactivation of HIV-1 Transcription.
Autorzy :
Wong ME; Life Sciences Discipline, Burnet Institute, Melbourne, Australia.; Department of Immunology, Central Clinical School, Monash University, Melbourne, Australia.
Johnson CJ; Bioimaging Platform, La Trobe University, Melbourne, Australia.
Hearps AC; Life Sciences Discipline, Burnet Institute, Melbourne, Australia.; Department of Infectious Diseases, Monash University, Melbourne, Australia.
Jaworowski A; Department of Infectious Diseases, Monash University, Melbourne, Australia.; School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia.
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Źródło :
Journal of virology [J Virol] 2021 Sep 09; Vol. 95 (19), pp. e0022721. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Virus Activation*
HIV-1/*genetics
HIV-1/*physiology
Macrophages/*virology
Bryostatins/pharmacology ; Cytokines/pharmacology ; HIV-1/drug effects ; Humans ; Panobinostat/pharmacology ; T-Lymphocytes/virology ; Virus Latency ; Virus Replication ; Vorinostat/pharmacology
Czasopismo naukowe
Tytuł :
Strategies and Progress in CXCR4-Targeted Anti-Human Immunodeficiency Virus (HIV) Therapeutic Development.
Autorzy :
Huang LSM; Center for Innovative Phage Applications and Therapeutics, Department of Medicine, Division of Infectious Diseases and Global Public Health, School of Medicine, University of California San Diego, La Jolla, California, USA.
Snyder EY; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, California, USA.; Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA.
Schooley RT; Center for Innovative Phage Applications and Therapeutics, Department of Medicine, Division of Infectious Diseases and Global Public Health, School of Medicine, University of California San Diego, La Jolla, California, USA.
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Źródło :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Sep 07; Vol. 73 (5), pp. 919-924.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Acquired Immunodeficiency Syndrome*
HIV Infections*/drug therapy
HIV-1*
Humans ; Receptors, CCR5 ; Receptors, CXCR4
Czasopismo naukowe
Tytuł :
A Stronger Innate Immune Response During Hyperacute Human Immunodeficiency Virus Type 1 (HIV-1) Infection Is Associated With Acute Retroviral Syndrome.
Autorzy :
Hassan AS; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Department of Translational Medicine, Lund University, Sweden.
Hare J; IAVI Human Immunology Laboratory, Imperial College, London, United Kingdom.; IAVI, New York, New York, USA, and Nairobi, Kenya.
Gounder K; Africa Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Nazziwa J; Department of Translational Medicine, Lund University, Sweden.
Karlson S; Department of Translational Medicine, Lund University, Sweden.
Olsson L; Department of Internal Medicine, Helsingborg Hospital, Helsingborg, Sweden.
Streatfield C; Imperial College London, London, United Kingdom.
Kamali A; IAVI, New York, New York, USA, and Nairobi, Kenya.
Karita E; Rwanda/Zambia HIV Research Group, Kigali, Rwanda and Lusaka, Zambia.
Kilembe W; Rwanda/Zambia HIV Research Group, Kigali, Rwanda and Lusaka, Zambia.
Price MA; IAVI, New York, New York, USA, and Nairobi, Kenya.; UCSF Department of Epidemiology and Biostatistics, San Francisco,California, USA.
Borrow P; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Björkman P; Department of Translational Medicine, Lund University, Sweden.
Kaleebu P; Medical Research Council/Uganda Virus Research Institute, Uganda, and London School of Hygiene and Tropical Medicine, London, United Kingdom.
Allen S; Rwanda/Zambia HIV Research Group, Kigali, Rwanda and Lusaka, Zambia.; Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.
Hunter E; Rwanda/Zambia HIV Research Group, Kigali, Rwanda and Lusaka, Zambia.; Emory Vaccine Center, Emory University, Atlanta, Georgia, USA.
Ndung'u T; Africa Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Max Planck Institute for Infection Biology, Berlin, Germany.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.; Division of Infection and Immunity, University College London, London, United Kingdom.
Gilmour J; IAVI Human Immunology Laboratory, Imperial College, London, United Kingdom.
Rowland-Jones S; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Esbjörnsson J; Department of Translational Medicine, Lund University, Sweden.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Sanders EJ; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
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Źródło :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Sep 07; Vol. 73 (5), pp. 832-841.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Acute Retroviral Syndrome*
HIV Infections*
HIV-1*
Chemokine CXCL10 ; Humans ; Immunity, Innate
Czasopismo naukowe
Tytuł :
Systemic DPP4/CD26 is associated with natural HIV-1 control: Implications for COVID-19 susceptibility.
Autorzy :
Govender Y; Centre for HIV & STIs, National Institute for Communicable Diseases, National Health Laboratory Service and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Shalekoff S; Centre for HIV & STIs, National Institute for Communicable Diseases, National Health Laboratory Service and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ebrahim O; Department of Therapeutic Sciences, Division of Pharmacology, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Waja Z; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Medical Research Council Soweto Matlosana Centre for HIV/AIDS and TB Research, South Africa.
Chaisson RE; Johns Hopkins University Centre for AIDS Research, Baltimore, MD, United States.
Martinson N; Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Medical Research Council Soweto Matlosana Centre for HIV/AIDS and TB Research, South Africa.
Tiemessen CT; Centre for HIV & STIs, National Institute for Communicable Diseases, National Health Laboratory Service and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: .
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2021 Sep; Vol. 230, pp. 108824. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
HIV-1*
SARS-CoV-2*
COVID-19/*complications
Dipeptidyl Peptidase 4/*metabolism
HIV Infections/*complications
Adult ; CD4 Lymphocyte Count ; Case-Control Studies ; Comorbidity ; Cross-Sectional Studies ; Disease Susceptibility ; Female ; Humans ; Male ; Risk Factors ; South Africa ; Viral Load ; Young Adult
Czasopismo naukowe
Tytuł :
Genetic Diversity and Drug Resistance Mutations in Reverse Transcriptase and Protease Genes of HIV-1 Isolates from Southwestern Siberia.
Autorzy :
Rudometova NB; Department of Bioengineering, State Research Center of Virology and Biotechnology 'Vector', Koltsovo, Russia.
Shcherbakova NS; Department of Bioengineering, State Research Center of Virology and Biotechnology 'Vector', Koltsovo, Russia.
Shcherbakov DN; Department of Bioengineering, State Research Center of Virology and Biotechnology 'Vector', Koltsovo, Russia.
Mishenova EV; Budgetary Health Care Institution of the Republic of Altai 'Center for the Prevention and Control of AIDS', Gorno-Altaysk, Russia.
Delgado E; HIV Biology and Variability Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
Ilyichev AA; Department of Bioengineering, State Research Center of Virology and Biotechnology 'Vector', Koltsovo, Russia.
Karpenko LI; Department of Bioengineering, State Research Center of Virology and Biotechnology 'Vector', Koltsovo, Russia.
Thomson MM; HIV Biology and Variability Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
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Źródło :
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2021 Sep; Vol. 37 (9), pp. 716-723. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Infections*/epidemiology
HIV-1*/genetics
Drug Resistance ; Drug Resistance, Viral/genetics ; Genotype ; HIV Protease/genetics ; HIV Reverse Transcriptase/genetics ; Humans ; Mutation ; Peptide Hydrolases ; Phylogeny ; RNA-Directed DNA Polymerase ; Siberia/epidemiology
Czasopismo naukowe
Tytuł :
Possibility of HIV-1 protease inhibitors-clinical trial drugs as repurposed drugs for SARS-CoV-2 main protease: a molecular docking, molecular dynamics and binding free energy simulation study.
Autorzy :
Ancy I; Laboratory of Biocrystallography and Computational Molecular Biology, Department of Physics, Periyar University, Salem, India.
Sivanandam M; Laboratory of Biocrystallography and Computational Molecular Biology, Department of Physics, Periyar University, Salem, India.
Kumaradhas P; Laboratory of Biocrystallography and Computational Molecular Biology, Department of Physics, Periyar University, Salem, India.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Sep; Vol. 39 (15), pp. 5368-5375. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*
HIV-1*
Pharmaceutical Preparations*
HIV Protease/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Pandemics ; Peptide Hydrolases ; Protease Inhibitors/pharmacology ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Real-World Adherence to Antiretroviral Therapy Among HIV-1 Patients Across the United States.
Autorzy :
McComsey GA; University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH, USA.
Lingohr-Smith M; Novosys Health, Green Brook, NJ, USA.
Rogers R; Janssen Scientific Affairs LLC, Titusville, NJ, USA.
Lin J; Novosys Health, Green Brook, NJ, USA.
Donga P; Janssen Scientific Affairs LLC, Titusville, NJ, USA. .
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Źródło :
Advances in therapy [Adv Ther] 2021 Sep; Vol. 38 (9), pp. 4961-4974. Date of Electronic Publication: 2021 Aug 14.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents*/therapeutic use
Diabetes Mellitus, Type 2*/drug therapy
HIV Infections*/drug therapy
HIV Infections*/epidemiology
HIV-1*
Adult ; Female ; Humans ; Male ; Medicaid ; Medication Adherence ; Middle Aged ; Retrospective Studies ; United States/epidemiology
Czasopismo naukowe
Tytuł :
Correlates of Adherence to the Dapivirine Vaginal Ring for HIV-1 Prevention.
Autorzy :
Husnik MJ; Fred Hutchinson Cancer Research Center, Seattle, USA.; University of Washington, Seattle, USA.
Brown ER; Fred Hutchinson Cancer Research Center, Seattle, USA.
Dadabhai SS; Johns Hopkins Bloomberg School of Public Health, Blantyre, Malawi.
Gaffoor Z; South African Medical Research Council, Durban, South Africa.
Jeenarain N; South African Medical Research Council, Durban, South Africa.
Kiweewa FM; MU-JHU Research Collaboration, Kampala, Uganda.
Livant E; Magee-Womens Research Institute, Pittsburgh, USA.
Mansoor LE; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.
Mirembe BG; MU-JHU Research Collaboration, Kampala, Uganda.
Palanee-Phillips T; Wits Reproductive Health and HIV Institute, University of the Witwatersrand, School of Clinical Medicine, Johannesburg, South Africa.
Singh D; Magee-Womens Research Institute, Pittsburgh, USA.
Siva S; South African Medical Research Council, Durban, South Africa.
Soto-Torres L; National Institutes of Health, Bethesda, USA.
van der Straten A; RTI International, Women's Global Health Imperative, San Francisco, CA, USA.; Center for AIDS Prevention Studies, Department of Medicine, UCSF, San Francisco, CA, USA.
Baeten JM; University of Washington, Seattle, USA. .; Department of Global Health, University of Washington, 325 Ninth Avenue, Box 359927, Seattle, WA, 98104, USA. .
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Corporate Authors :
M. T. N.-020/ASPIRE Study Team
Źródło :
AIDS and behavior [AIDS Behav] 2021 Sep; Vol. 25 (9), pp. 2801-2814. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Anti-HIV Agents*/therapeutic use
Contraceptive Devices, Female*
HIV Infections*/drug therapy
HIV Infections*/prevention & control
HIV-1*
Female ; Humans ; Pyrimidines
Czasopismo naukowe

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