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Tytuł:
Identification of 5' upstream sequence involved in HSPBP1 gene transcription and its downregulation during HIV-1 infection.
Autorzy:
Iyer K; National Centre for Cell Science, NCCS Complex, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, Maharashtra 411007, India.
Mitra A; National Centre for Cell Science, NCCS Complex, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, Maharashtra 411007, India.
Mitra D; National Centre for Cell Science, NCCS Complex, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, Maharashtra 411007, India. Electronic address: .
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Źródło:
Virus research [Virus Res] 2023 Jan 15; Vol. 324, pp. 199034. Date of Electronic Publication: 2022 Dec 26.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*/genetics
HIV-1*/metabolism
Humans ; Transcriptional Activation ; Down-Regulation ; Promoter Regions, Genetic ; Transcription, Genetic ; tat Gene Products, Human Immunodeficiency Virus/genetics ; Adaptor Proteins, Signal Transducing/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
Association of human cytomegalovirus in urine with end-organ diseases in stage 2/3 HIV-1-infected individuals.
Autorzy:
Zhao F; Department of Infectious Diseases, National Clinical Center for Infectious Diseases, Third People's Hospital of Shenzhen (Second Affiliated Hospital of Southern University of Science and Technology), Shenzhen, Guangdong, PR China.
Fung TY; Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region (HKSAR), PR China.
Chen Z; AIDS Institute, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, HKSAR, PR China; Department of Microbiology, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, HKSAR, PR China. Electronic address: .
Wang H; Department of Infectious Diseases, National Clinical Center for Infectious Diseases, Third People's Hospital of Shenzhen (Second Affiliated Hospital of Southern University of Science and Technology), Shenzhen, Guangdong, PR China. Electronic address: .
Cheung AKL; Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region (HKSAR), PR China. Electronic address: .
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Źródło:
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2023 Jan; Vol. 158, pp. 105351. Date of Electronic Publication: 2022 Dec 11.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*/genetics
Cytomegalovirus Infections*/diagnosis
HIV Infections*/complications
HIV Infections*/epidemiology
HIV Infections*/drug therapy
Humans ; Cytomegalovirus ; Retrospective Studies ; DNA, Viral/urine
Czasopismo naukowe
Szczegóły
Tytuł:
New insights into transcription elongation control of HIV-1 latency and rebound.
Autorzy:
Mbonye U; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.
Kizito F; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.
Karn J; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA. Electronic address: .
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Źródło:
Trends in immunology [Trends Immunol] 2023 Jan; Vol. 44 (1), pp. 60-71. Date of Electronic Publication: 2022 Dec 08.
Typ publikacji:
Journal Article; Review
MeSH Terms:
HIV-1*
HIV Infections*
Humans ; Transcription, Genetic ; Virus Latency ; Positive Transcriptional Elongation Factor B/genetics ; Positive Transcriptional Elongation Factor B/metabolism ; CD4-Positive T-Lymphocytes/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
HIV-1 gp120-CXCR4 recognition probed with synthetic nanomolar affinity D-peptides containing fragments of gp120 V3 loop.
Autorzy:
Zhu R; School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Meng Q; School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Zhang H; Division of Infectious Diseases and Global Public Heath, Department of Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA; Ciechanover Institute of Precision and Regenerative Medicine, School of Life and Health Sciences, Chinese University of Hong Kong, Shenzhen, 518172, China.
Zhang G; School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Huang LSM; Division of Infectious Diseases and Global Public Heath, Department of Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Xu Y; Ciechanover Institute of Precision and Regenerative Medicine, School of Life and Health Sciences, Chinese University of Hong Kong, Shenzhen, 518172, China.
Schooley RT; Division of Infectious Diseases and Global Public Heath, Department of Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
An J; Division of Infectious Diseases and Global Public Heath, Department of Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. Electronic address: .
Huang Z; School of Life Sciences, Tsinghua University, Beijing, 100084, China; Ciechanover Institute of Precision and Regenerative Medicine, School of Life and Health Sciences, Chinese University of Hong Kong, Shenzhen, 518172, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 15; Vol. 244, pp. 114797. Date of Electronic Publication: 2022 Sep 28.
Typ publikacji:
Journal Article
MeSH Terms:
HIV Envelope Protein gp120*/chemistry
HIV-1*/physiology
Peptide Fragments*/chemistry
Receptors, CXCR4*/analysis
Receptors, CXCR4*/chemistry
Receptors, CXCR4*/genetics
Receptors, Virus*/chemistry
Receptors, Virus*/genetics
Virus Internalization*
Molecular Probes*/chemistry
Humans ; Chemokine CXCL12/metabolism ; Ligands ; Receptors, CCR5/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Different dendritic cells-based vaccine constructs influence HIV-1 antigen-specific immunological responses and cytokine generation in virion-exposed splenocytes.
Autorzy:
Milani A; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran; Department of Molecular and Cellular Sciences, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Agi E; Iranian Comprehensive Hemophilia Care Center, Tehran, Iran.
Hassan Pouriayevali M; Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran.
Motamedi-Rad M; Department of Molecular Virology, Pasteur Institute of Iran, Tehran, Iran.
Motevalli F; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
Bolhassani A; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran. Electronic address: A_.
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2022 Dec; Vol. 113 (Pt A), pp. 109406. Date of Electronic Publication: 2022 Nov 08.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*
Vaccines*
Animals ; Mice ; Cytokines ; HSP27 Heat-Shock Proteins ; Escherichia coli ; Spleen ; Virion ; Antigens, Viral ; Dendritic Cells
Czasopismo naukowe
Szczegóły
Tytuł:
Characterization of a novel HIV-1 circulating recombinant form, CRF91_cpx, comprising CRF02_AG, G, J, and U, mostly among men who have sex with men.
Autorzy:
Topcu C; Department of Biological Sciences, University of Cyprus, 1 University Avenue, Aglantzia, Nicosia, Cyprus.
Georgiou V; Department of Biological Sciences, University of Cyprus, 1 University Avenue, Aglantzia, Nicosia, Cyprus.
Rodosthenous JH; Department of Biological Sciences, University of Cyprus, 1 University Avenue, Aglantzia, Nicosia, Cyprus.
Demetriades I; AIDS Clinic, Larnaca General Hospital, Larnaca, Cyprus.
Foley BT; Los Alamos National Laboratory, T-6 Theoretical Biology and Biophysics, Los Alamos, NM, USA.
G Kostrikis L; Department of Biological Sciences, University of Cyprus, 1 University Avenue, Aglantzia, Nicosia, Cyprus.; Cyprus Academy of Sciences, Letters, and Arts, Nicosia, Cyprus.
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Źródło:
Virulence [Virulence] 2022 Dec; Vol. 13 (1), pp. 1331-1348.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections*
HIV-1*/genetics
Sexual and Gender Minorities*
Genome, Viral ; Genotype ; Homosexuality, Male ; Humans ; Male ; Nucleotides ; Phylogeny ; Recombination, Genetic ; Sequence Analysis, DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4 T cells.
Autorzy:
Wen J; Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China.; University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Li X; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
Zhao QX; Department of Infection, Zhengzhou Sixth People's Hospital, Zhengzhou, People's Republic of China.
Yang XF; Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
Wu ML; College of Life Science, Henan Normal University, Xinxiang, People's Republic of China.
Yan Q; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
Chang J; College of Life Science, Henan Normal University, Xinxiang, People's Republic of China.
Wang H; Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Jin X; College of Life Science, Henan Normal University, Xinxiang, People's Republic of China.
Su X; Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Deng K; Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
Chen L; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
Wang JH; University of Chinese Academy of Sciences, Beijing, People's Republic of China.; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
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Źródło:
Emerging microbes & infections [Emerg Microbes Infect] 2022 Dec; Vol. 11 (1), pp. 391-405.
Typ publikacji:
Journal Article
MeSH Terms:
CD4-Positive T-Lymphocytes/*virology
Glycogen Synthase Kinase 3/*antagonists & inhibitors
HIV-1/*growth & development
Indoles/*pharmacology
Oximes/*pharmacology
Virus Activation/*drug effects
Virus Latency/*drug effects
Animals ; CD4-Positive T-Lymphocytes/immunology ; Cell Line, Tumor ; HIV-1/drug effects ; HIV-1/genetics ; HeLa Cells ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Humans ; Macaca mulatta ; Transcription, Genetic/drug effects ; U937 Cells ; Virus Activation/genetics ; Virus Latency/genetics ; Wnt Proteins/metabolism ; beta Catenin/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities.
Autorzy:
Ming W; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China.
Lu WL; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China.
Pannecouque C; KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, B-3000, Leuven, Belgium.
Chen J; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China.
Wang HF; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China; Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan, 430205, China.
Xiao YQ; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China.
Hu S; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China.
Gu SX; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China; Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan, 430205, China. Electronic address: .
Zhu YY; School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430205, China. Electronic address: .
Chen FE; Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China; Department of Chemistry, Fudan University, Shanghai, 200433, China; Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan, 430205, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Feb 15; Vol. 248, pp. 115114. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-HIV Agents*/chemistry
HIV-1*/metabolism
Delavirdine ; Drug Design ; Reverse Transcriptase Inhibitors/chemistry ; Structure-Activity Relationship ; HIV Reverse Transcriptase
Czasopismo naukowe
Szczegóły
Tytuł:
Development of novel S-N 3 -DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity.
Autorzy:
Ling X; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, PR China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, PR China; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, PR China.
Hao QQ; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, PR China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, PR China; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, PR China.
Huang WJ; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, PR China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, PR China.
Pannecouque C; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
De Clercq E; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
Wang S; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, PR China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, PR China. Electronic address: .
Chen FE; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, PR China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, PR China; Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, PR China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Feb 05; Vol. 247, pp. 115042. Date of Electronic Publication: 2022 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*/metabolism
Anti-HIV Agents*/pharmacology
Reverse Transcriptase Inhibitors/pharmacology ; Structure-Activity Relationship ; HIV Reverse Transcriptase ; Pyrimidines/pharmacology ; Pyrimidinones/pharmacology ; Heterocyclic Compounds, 1-Ring ; Drug Design
Czasopismo naukowe
Szczegóły
Tytuł:
Identification of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.
Autorzy:
Feng D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China. Electronic address: .
Zuo X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Zhao F; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Lin H; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Dai J; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Sun Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Clercq E; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000, Leuven, Belgium.
Pannecouque C; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000, Leuven, Belgium.
Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China. Electronic address: .
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Feb 05; Vol. 247, pp. 115045. Date of Electronic Publication: 2022 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-HIV Agents*/pharmacology
Anti-HIV Agents*/chemistry
HIV-1*
Structure-Activity Relationship ; Drug Design ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/chemistry ; HIV Reverse Transcriptase ; Molecular Structure
Czasopismo naukowe
Szczegóły
Tytuł:
HIV-1 reservoir evolution in infants infected with clade C from Mozambique.
Autorzy:
Koofhethile CK; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA; Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Rinaldi S; University of Miami, Miami, Florida, USA.
Rassadkina Y; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
Dinh VB; University of Miami, Miami, Florida, USA.
Gao C; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
Pallikkuth S; University of Miami, Miami, Florida, USA.
Garcia-Broncano P; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
de Armas LR; University of Miami, Miami, Florida, USA.
Pahwa R; University of Miami, Miami, Florida, USA.
Cotugno N; Academic Department of Pediatrics, Research Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
Vaz P; Fundação Ariel Glaser contra o SIDA Pediátrico, Maputo, Mozambique.
Lain MG; Fundação Ariel Glaser contra o SIDA Pediátrico, Maputo, Mozambique.
Palma P; Academic Department of Pediatrics, Research Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy; Chair of Pediatrics, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Yu XG; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
Shapiro R; Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Pahwa S; University of Miami, Miami, Florida, USA.
Lichterfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address: .
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Źródło:
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2023 Feb; Vol. 127, pp. 129-136. Date of Electronic Publication: 2022 Dec 05.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*/genetics
HIV Seropositivity*
HIV Infections*
Humans ; Infant ; Mozambique/epidemiology ; DNA, Viral/genetics ; Proviruses/genetics ; CD4-Positive T-Lymphocytes ; Viral Load
Czasopismo naukowe
Szczegóły
Tytuł:
A SERS based clinical study on HIV-1 viral load quantification and determination of disease prognosis.
Autorzy:
Yadav S; Department of Physics, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
Senapati S; School of Interdisciplinary Research (SIRe), Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India. Electronic address: .
Kulkarni SS; Division of Virology, ICMR-National AIDS Research Institute, Bhosari, Pune 413404, India. Electronic address: .
Singh JP; Department of Physics, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India. Electronic address: .
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Źródło:
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2023 Feb; Vol. 239, pp. 112629. Date of Electronic Publication: 2022 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*
Nanotubes*/chemistry
Humans ; Viral Load ; Gold/chemistry ; Spectrum Analysis, Raman/methods
Czasopismo naukowe
Szczegóły
Tytuł:
Identification and genomic characterization of a novel HIV-1 unique recombinant form (CRF01_AE/CRF07_BC) in Zhejiang Province, China.
Autorzy:
Fan Q; Department of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China.
Liu J; School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, 325035, People's Republic of China.
Chai C; Department of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China.
Zhu S; Department of Microbiological Analysis, Jinhua Municipal Center for Disease Control and Prevention, Jinhua, 321002, People's Republic of China.
Fang Q; Department of Microbiological Analysis, Jinhua Municipal Center for Disease Control and Prevention, Jinhua, 321002, People's Republic of China.
Guo Z; Department of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China.
Xia Y; Department of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China.
Ding X; Department of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China.
Zhang J; Department of HIV/AIDS Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, No.3399, Binsheng Road, Hangzhou, 310051, People's Republic of China. .
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Źródło:
Virus genes [Virus Genes] 2023 Feb; Vol. 59 (1), pp. 142-147. Date of Electronic Publication: 2022 Oct 27.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*/genetics
HIV Infections*
Humans ; Recombination, Genetic ; Genome, Viral/genetics ; Phylogeny ; Genotype ; Sequence Analysis, DNA ; China/epidemiology ; Genomics
Czasopismo naukowe
Szczegóły
Tytuł:
4-phenylquinoline-8-amine induces HIV-1 reactivation and apoptosis in latently HIV-1 infected cells.
Autorzy:
Kitamura H; Department of Molecular Virology, Tokyo Medical and Dental University, Tokyo, Japan.
Sukegawa S; Department of Molecular Virology, Tokyo Medical and Dental University, Tokyo, Japan; Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan.
Matsuda K; AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan; Japan Foundation for AIDS Prevention, Tokyo, Japan.
Tanimoto K; Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan.
Kobayakawa T; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Takahashi K; Department of Molecular Virology, Tokyo Medical and Dental University, Tokyo, Japan.
Tamamura H; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
Tsuchiya K; AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.
Gatanaga H; AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.
Maeda K; Division of Antiviral Therapy, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima, Japan. Electronic address: .
Takeuchi H; Department of Molecular Virology, Tokyo Medical and Dental University, Tokyo, Japan; Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Jan 22; Vol. 641, pp. 139-147. Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
HIV Infections*/metabolism
HIV-1*
Humans ; Apoptosis ; CD4-Positive T-Lymphocytes ; Virus Activation ; Virus Latency ; Amines/pharmacology
Czasopismo naukowe
Szczegóły
Tytuł:
Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation.
Autorzy:
Feng D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Lin H; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Jiang L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Dai J; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Zhang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Zhou Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; Department of Cancer Center, Shandong University, Jinan, 250117, PR China.
Sun Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Wang Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China.
Clercq E; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000, Leuven, Belgium.
Pannecouque C; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000, Leuven, Belgium.
Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China. Electronic address: .
Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China. Electronic address: .
Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, 250012, Jinan, Shandong, PR China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012, Jinan, Shandong, PR China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 15; Vol. 246, pp. 114957. Date of Electronic Publication: 2022 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-HIV Agents*/chemistry
HIV-1*/metabolism
Structure-Activity Relationship ; Molecular Docking Simulation ; Drug Design ; HIV Reverse Transcriptase ; Reverse Transcriptase Inhibitors/chemistry ; Pyrimidines/chemistry
Czasopismo naukowe
Szczegóły
Tytuł:
Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles.
Autorzy:
Ajoge HO; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada.
Renner TM; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Bélanger K; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Greig M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Dankar S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Kohio HP; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada.
Coleman MD; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada.
Ndashimye E; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada.
Arts EJ; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada.
Langlois MA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. .; Ottawa Center for Infection, Immunity and Inflammation (CI3), Ottawa, ON, Canada. .
Barr SD; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada. .
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Źródło:
Nature communications [Nat Commun] 2023 Jan 10; Vol. 14 (1), pp. 16. Date of Electronic Publication: 2023 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*/genetics
HIV-1*/metabolism
HIV Infections*
Humans ; Cytidine Deaminase/genetics ; Cytidine Deaminase/metabolism ; APOBEC-3G Deaminase/metabolism ; Cytosine Deaminase/genetics ; Cytosine Deaminase/metabolism ; Proteins/metabolism ; Anti-Retroviral Agents ; Virus Integration/genetics ; Cytidine/metabolism ; APOBEC Deaminases/genetics ; APOBEC Deaminases/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study.
Autorzy:
Zhou Z; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
Meng B; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
An J; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
Zhao F; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
Sun Y; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
Zeng D; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
Wang W; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
Gao S; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
Xia Y; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
Dun C; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.
De Clercq E; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000 Leuven, Belgium.
Pannecouque C; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, K.U. Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000 Leuven, Belgium.
Zhan P; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Shandong University, 44 West Culture Road, Jinan 250012, China.
Kang D; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Shandong University, 44 West Culture Road, Jinan 250012, China.
Liu X; Key Laboratory of Chemical Biology (Ministry of Education), Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan 250012, China.; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Shandong University, 44 West Culture Road, Jinan 250012, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 07; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 07.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*/metabolism
Anti-HIV Agents*/pharmacology
Anti-HIV Agents*/chemistry
Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/chemistry ; HIV Reverse Transcriptase/metabolism ; Drug Design ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The diverse roles of miRNAs in HIV pathogenesis: Current understanding and future perspectives.
Autorzy:
Rashid F; Department of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China.
Zaongo SD; Department of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China.
Song F; Basic Medicine College, Chongqing Medical University, Chongqing, China.
Chen Y; Department of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China.
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Źródło:
Frontiers in immunology [Front Immunol] 2023 Jan 05; Vol. 13, pp. 1091543. Date of Electronic Publication: 2023 Jan 05 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review
MeSH Terms:
MicroRNAs*/metabolism
HIV Infections*/drug therapy
HIV Infections*/genetics
HIV-1*/physiology
Acquired Immunodeficiency Syndrome*/drug therapy
Humans ; Antiretroviral Therapy, Highly Active
Czasopismo naukowe
Szczegóły
Tytuł:
Evaluating lncRNA Expression Patterns during HIV-1 Treatment Interruption.
Autorzy:
Schynkel T; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
van Snippenberg W; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Van Hecke C; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Trypsteen W; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University and Ghent University Hospital, 9000 Ghent, Belgium.
Pokaż więcej
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 05; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/therapeutic use
HIV-1*
HIV Infections*/drug therapy
HIV Infections*/genetics
Humans ; Leukocytes, Mononuclear ; Anti-Retroviral Agents/therapeutic use ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure-Based Identification of Natural-Product-Derived Compounds with Potential to Inhibit HIV-1 Entry.
Autorzy:
Ugwu-Korie N; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 54, Ghana.
Quaye O; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 54, Ghana.
Wright E; School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.
Languon S; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 54, Ghana.; Cellular and Molecular Biomedical Sciences Program, University of Vermont, Burlington, VT 05405, USA.
Agyapong O; Department of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 77, Ghana.; Department of Parasitology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.
Broni E; Department of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 77, Ghana.; Department of Parasitology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, Legon, Accra P.O. Box LG 581, Ghana.; Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA.
Gupta Y; Infectious Diseases, Mayo Clinic, Jacksonville, FL 32224, USA.
Kempaiah P; Infectious Diseases, Mayo Clinic, Jacksonville, FL 32224, USA.
Kwofie SK; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 54, Ghana.; Department of Biomedical Engineering, School of Engineering Sciences, College of Basic & Applied Sciences, University of Ghana, Legon, Accra P.O. Box LG 77, Ghana.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jan 04; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 04.
Typ publikacji:
Journal Article
MeSH Terms:
Broadly Neutralizing Antibodies*
HIV-1*/drug effects
Biological Products*/pharmacology
Humans ; CD4 Antigens/metabolism ; HIV Antibodies ; HIV Envelope Protein gp120 ; HIV Infections ; Molecular Docking Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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