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Tytuł :
Methylation-dependent SUMOylation of the architectural transcription factor HMGA2.
Autorzy :
Stabell M; Department of Tumor Biology, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, PO Box 4953 Nydalen, N-0424, Oslo, Norway; Department of Molecular Biosciences, University of Oslo, PO Box 1066 Blindern, N-0316, Oslo, Norway.
Sæther T; Department of Molecular Biosciences, University of Oslo, PO Box 1066 Blindern, N-0316, Oslo, Norway.
Røhr ÅK; Department of Molecular Biosciences, University of Oslo, PO Box 1066 Blindern, N-0316, Oslo, Norway.
Gabrielsen OS; Department of Molecular Biosciences, University of Oslo, PO Box 1066 Blindern, N-0316, Oslo, Norway.
Myklebost O; Department of Tumor Biology, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, PO Box 4953 Nydalen, N-0424, Oslo, Norway; Department of Molecular Biosciences, University of Oslo, PO Box 1066 Blindern, N-0316, Oslo, Norway. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 07; Vol. 552, pp. 91-97. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HMGA2 Protein/*metabolism
Lysine/*metabolism
Transcription Factors/*metabolism
Amino Acid Motifs/genetics ; Amino Acid Sequence ; Binding Sites/genetics ; Cell Line ; HMGA2 Protein/chemistry ; HMGA2 Protein/genetics ; Humans ; Lysine/chemistry ; Lysine/genetics ; Methylation ; Protein Binding ; Protein Domains ; Sequence Homology, Amino Acid ; Sumoylation ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Ubiquitin-Conjugating Enzymes/chemistry ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism
Czasopismo naukowe
Tytuł :
MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy.
Autorzy :
Mansoori B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark; Aging Research Institute, Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Duijf PHG; Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia; University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Australia.
Mohammadi A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Safarzadeh E; Department of Microbiology and Immunology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Ditzel HJ; Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark; Department of Oncology, Odense University Hospital, Odense, Denmark; Academy of Geriatric Cancer Research (AgeCare), Odense University Hospital, Odense, Denmark.
Gjerstorff MF; Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark; Department of Oncology, Odense University Hospital, Odense, Denmark; Academy of Geriatric Cancer Research (AgeCare), Odense University Hospital, Odense, Denmark.
Cho WC; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong. Electronic address: .
Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jul 01; Vol. 276, pp. 119431. Date of Electronic Publication: 2021 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Breast Neoplasms/*pathology
HMGA2 Protein/*metabolism
MicroRNAs/*genetics
Apoptosis ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Cycle ; Cell Movement ; Cell Proliferation ; Female ; HMGA2 Protein/genetics ; Humans ; Prognosis ; Survival Rate ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma.
Autorzy :
Shirai K; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Department of Gastroenterology, Wakayama Medical University, Wakayama, Japan.
Nagae G; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Seki M; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kudo Y; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kamio A; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Laboratory of Genetics, Department of Biological Sciences, The University of Tokyo, Tokyo, Japan.
Hayashi A; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Department of Pathology, Kyorin University Faculty of Medicine, Mitaka, Japan.
Okabe A; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Ota S; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Tsutsumi S; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Fujita T; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Yamamoto S; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Nakaki R; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Kanki Y; Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Osawa T; Division of Integrative Nutriomics and Oncology, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Midorikawa Y; Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
Tateishi K; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Ichinose M; Department of Gastroenterology, Wakayama Medical University, Wakayama, Japan.; Faculty of Medicine, Teikyo University, Tokyo, Japan.
Aburatani H; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Jul; Vol. 112 (7), pp. 2855-2869. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
HMGA2 Protein/*genetics
Liver Neoplasms/*genetics
Mixed Function Oxygenases/*genetics
Neoplasm Proteins/*genetics
Proto-Oncogene Proteins/*genetics
Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Chromatin/genetics ; Cytosine/metabolism ; DNA Methylation ; Dioxygenases/metabolism ; Epigenesis, Genetic ; Gene Expression ; Gene Knockdown Techniques ; HMGA2 Protein/metabolism ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Mixed Function Oxygenases/metabolism ; Neoplasm Proteins/metabolism ; Proto-Oncogene Proteins/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
[RNA Binding Protein RBM47 Inhibits the K562 Cell Proliferation by Regulating HMGA2 mRNA Expression].
Autorzy :
Lei T; Department of Laboratory Medicine, Beijing Shijitan Hospital, Capital Medical University,Beijing 100038, China.
Cui J; Institute of Medicinal Plant Development,Peking Union Medical College,Chinese Academy of Medical Sciences, Beijing 100193, China,E-mail: .
Hou JL; Beijing University of Chinese Medicine, Beijing 100029, China,E-mail: .
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Jun; Vol. 29 (3), pp. 703-708.
Typ publikacji :
Journal Article
MeSH Terms :
HMGA2 Protein*/genetics
RNA-Binding Proteins*/genetics
Apoptosis ; Cell Proliferation ; Humans ; K562 Cells ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
Significance of HMGA2 expression as independent poor prognostic marker in perihilar and distal cholangiocarcinoma resected with curative intent.
Autorzy :
Takahashi T; Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Kawaji H; Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Tokyo Metropolitan Institute of Medical Sciences, Tokyo, Japan; RIKEN Preventive Medicine and Diagnosis Innovation Program, Wako, Japan.
Murakawa Y; RIKEN Preventive Medicine and Diagnosis Innovation Program, Wako, Japan; RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; RIKEN-HMC Clinical Omics Unit, RIKEN Baton Zone Program, Yokohama, Japan.
Hayashizaki Y; RIKEN Preventive Medicine and Diagnosis Innovation Program, Wako, Japan.
Murakami T; Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Yabushita Y; Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Homma Y; Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Kumamoto T; Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Matsuyama R; Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Endo I; Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan. Electronic address: .
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Źródło :
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2021 Feb; Vol. 47 (2), pp. 394-400. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bile Ducts, Extrahepatic*
Gene Expression Regulation, Neoplastic*
Pancreaticoduodenectomy*
Bile Duct Neoplasms/*genetics
Cholangiocarcinoma/*genetics
HMGA2 Protein/*genetics
Adult ; Aged ; Aged, 80 and over ; Bile Duct Neoplasms/metabolism ; Bile Duct Neoplasms/surgery ; Biomarkers, Tumor/biosynthesis ; Biomarkers, Tumor/genetics ; Cholangiocarcinoma/metabolism ; Cholangiocarcinoma/surgery ; DNA, Neoplasm/genetics ; DNA, Neoplasm/metabolism ; Female ; HMGA2 Protein/biosynthesis ; Humans ; Male ; Middle Aged ; Prognosis
Czasopismo naukowe
Tytuł :
Circular RNA 100146 Promotes Colorectal Cancer Progression by the MicroRNA 149/HMGA2 Axis.
Autorzy :
Liu K; Department of General Surgery, Rizhao People's Hospital, Rizhao City, China.
Mou Y; Department of General Surgery, Rizhao People's Hospital, Rizhao City, China.
Shi X; Department of Pediatrics, Chinese Medicine Hospital, Rizhao City, China.
Liu T; Rizhao City Tuberculosis Control Center, Rizhao City, China.
Chen Z; Department of General Surgery, Rizhao People's Hospital, Rizhao City, China.
Zuo X; Department of General Surgery, Rizhao People's Hospital, Rizhao City, China .
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2021 Jan 25; Vol. 41 (2). Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Colorectal Neoplasms/*genetics
HMGA2 Protein/*genetics
MicroRNAs/*genetics
RNA, Circular/*genetics
Aged ; Animals ; Antagomirs/genetics ; Antagomirs/metabolism ; Base Pairing ; Base Sequence ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Disease Progression ; Female ; Genes, Reporter ; HMGA2 Protein/antagonists & inhibitors ; HMGA2 Protein/metabolism ; Humans ; Luciferases/genetics ; Luciferases/metabolism ; Male ; Mice ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/metabolism ; Middle Aged ; Neoplasm Invasiveness ; RNA, Circular/antagonists & inhibitors ; RNA, Circular/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays.
Autorzy :
Su L; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
Bryan N; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL, 32827, USA.
Battista S; Istituto per l'Endocrinologia e l'Oncologia Sperimentale, CNR, Via Pansini 5, 80131, Naples, Italy.
Freitas J; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Biological Sciences, Florida International University, Miami, FL, 33199, USA.
Garabedian A; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
D'Alessio F; Dipartimento Di Medicina Molecolare E Biotecnologie Mediche, Università Degli Studi 'Federico II' Di Napoli, Naples, Italy.
Romano M; Dipartimento Di Medicina Molecolare E Biotecnologie Mediche, Università Degli Studi 'Federico II' Di Napoli, Naples, Italy.
Falanga F; Dipartimento Di Medicina Molecolare E Biotecnologie Mediche, Università Degli Studi 'Federico II' Di Napoli, Naples, Italy.
Fusco A; Dipartimento Di Medicina Molecolare E Biotecnologie Mediche, Università Degli Studi 'Federico II' Di Napoli, Naples, Italy.
Kos L; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Biological Sciences, Florida International University, Miami, FL, 33199, USA.
Chambers J; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Environmental Health Sciences, Florida International University, Miami, FL, 33199, USA.
Fernandez-Lima F; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA.
Chapagain PP; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA.; Department of Physics, Florida International University, Miami, FL, 33199, USA.
Vasile S; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL, 32827, USA.
Smith L; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL, 32827, USA.
Leng F; Biomolecular Sciences Institute, Florida International University, Miami, FL, 33199, USA. .; Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 02; Vol. 10 (1), pp. 18850. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*antagonists & inhibitors
HMGA1a Protein/*antagonists & inhibitors
HMGA2 Protein/*antagonists & inhibitors
Suramin/*chemistry
Adipogenesis/drug effects ; Amino Acid Motifs/drug effects ; Base Sequence/drug effects ; Binding Sites/drug effects ; Carcinogenesis/drug effects ; DNA/drug effects ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; HMGA1a Protein/chemistry ; HMGA1a Protein/genetics ; HMGA2 Protein/chemistry ; HMGA2 Protein/genetics ; High-Throughput Screening Assays ; Humans ; Suramin/isolation & purification ; Suramin/pharmacology
Czasopismo naukowe
Tytuł :
LncRNA LOXL1-AS1 controls osteogenic and adipocytic differentiation of bone marrow mesenchymal stem cells in postmenopausal osteoporosis through regulating the miR-196a-5p/Hmga2 axis.
Autorzy :
Zhang L; Department of Geriatrics, the First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhongshan 2nd Road, Guangzhou City, 510080, Guangdong Province, China. .
Xie H; Department of Ultrasound, Peking University Shenzhen Hospital, Shenzhen City, 518036, Guangdong Province, China.
Li S; Healthcare Office, the First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhongshan 2nd Road, Guangzhou City, 510080, Guangdong Province, China.
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Źródło :
Journal of bone and mineral metabolism [J Bone Miner Metab] 2020 Nov; Vol. 38 (6), pp. 794-805. Date of Electronic Publication: 2020 Jul 10.
Typ publikacji :
Journal Article
MeSH Terms :
Adipocytes/*metabolism
Cell Differentiation/*genetics
HMGA2 Protein/*genetics
Mesenchymal Stem Cells/*pathology
MicroRNAs/*genetics
Osteogenesis/*genetics
Osteoporosis, Postmenopausal/*genetics
RNA, Long Noncoding/*metabolism
Base Sequence ; Female ; Gene Expression Regulation ; HEK293 Cells ; HMGA2 Protein/metabolism ; Humans ; Mesenchymal Stem Cells/metabolism ; MicroRNAs/metabolism ; Osteoporosis, Postmenopausal/pathology ; RNA, Long Noncoding/genetics
Czasopismo naukowe
Tytuł :
Long Noncoding RNA LINC02163 Accelerates Malignant Tumor Behaviors in Breast Cancer by Regulating the MicroRNA-511-3p/HMGA2 Axis.
Autorzy :
Qin C; Department of Thyroid and Breast Surgery, The Second Affiliated Hospital of Soochow UniversitySuzhou, JiangsuP.R. China.
Jin L; Department of Thyroid and Breast Surgery, The Second Affiliated Hospital of Soochow UniversitySuzhou, JiangsuP.R. China.
Li J; Department of Thyroid and Breast Surgery, The Second Affiliated Hospital of Soochow UniversitySuzhou, JiangsuP.R. China.
Zha W; Department of General Surgery, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng City No. 1 Peoples HospitalYancheng, JiangsuP.R. China.
Ding H; Department of General Surgery, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng City No. 1 Peoples HospitalYancheng, JiangsuP.R. China.
Liu X; Department of Thyroid and Breast Surgery, The Second Affiliated Hospital of Soochow UniversitySuzhou, JiangsuP.R. China.
Zhu X; Department of Thyroid and Breast Surgery, The Second Affiliated Hospital of Soochow UniversitySuzhou, JiangsuP.R. China.
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Źródło :
Oncology research [Oncol Res] 2020 Dec 10; Vol. 28 (5), pp. 483-495. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*genetics
HMGA2 Protein/*genetics
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
Animals ; Apoptosis/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; HMGA2 Protein/metabolism ; Humans ; Lymphatic Metastasis/genetics ; Mice ; Mice, Inbred BALB C ; MicroRNAs/metabolism ; Prognosis ; RNA, Long Noncoding/metabolism ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
HMGA2 involvement in uterine leiomyomas development through angiogenesis activation.
Autorzy :
Ferrero H; IVIRMA Foundation, Valencia, Spain.
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Źródło :
Fertility and sterility [Fertil Steril] 2020 Nov; Vol. 114 (5), pp. 974-975. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Editorial; Comment
MeSH Terms :
HMGA2 Protein*/genetics
Leiomyoma*/diagnostic imaging
Leiomyoma*/genetics
Carcinogenesis ; Humans
Opinia redakcyjna
Tytuł :
Lupeol inhibits osteosarcoma progression by up-regulation of HMGA2 via regulating miR-212-3p.
Autorzy :
Zhong J; Department of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
He C; Department of Orthopedics, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Xu F; Department of Orthopedics, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Xu X; Basic Medical School, Gannan Medical University, Ganzhou, Jiangxi, China.
Liu L; Department of Orthopedics, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Xu M; Department of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Guo Z; Department of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Wang Y; Department of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Liao J; Department of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Li Y; Department of Oncology, The First Hospital of Tianmen City of Hubei Province, No. 1, East Renmin Avenue, Tianmen, 431700, Hubei, China. .
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Źródło :
Journal of orthopaedic surgery and research [J Orthop Surg Res] 2020 Sep 03; Vol. 15 (1), pp. 374. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*genetics
Bone Neoplasms/*pathology
Gene Expression Regulation, Neoplastic/*drug effects
HMGA2 Protein/*genetics
HMGA2 Protein/*metabolism
MicroRNAs/*genetics
MicroRNAs/*metabolism
Osteosarcoma/*genetics
Osteosarcoma/*pathology
Pentacyclic Triterpenes/*pharmacology
Up-Regulation/*drug effects
Antineoplastic Agents ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Disease Progression ; HMGA2 Protein/physiology ; Humans ; Neoplasm Invasiveness/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Cr (VI) induced mitophagy via the interaction of HMGA2 and PARK2.
Autorzy :
Gao Z; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Mei J; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Yan X; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Jiang L; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Geng C; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Li Q; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Shi X; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China.
Liu Y; School of Life Science and Medicine, Dalian University of Technology, Panjin 124221, China.
Cao J; Department of Occupational and Environmental Health, Dalian Medical University, No. 9 W. Lvshun South Road, Dalian 116044, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 15; Vol. 333, pp. 261-268. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Chromium/*toxicity
Environmental Pollutants/*toxicity
HMGA2 Protein/*metabolism
Lung/*drug effects
Mitophagy/*drug effects
Ubiquitin-Protein Ligases/*metabolism
A549 Cells ; Animals ; Gene Expression/drug effects ; HEK293 Cells ; HMGA2 Protein/genetics ; Humans ; Lung/metabolism ; Lung/pathology ; Mice ; Mice, Inbred BALB C ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Protein Transport ; Transfection ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
Identification of the Effects of Aspirin and Sulindac Sulfide on the Inhibition of HMGA2-Mediated Oncogenic Capacities in Colorectal Cancer.
Autorzy :
Ekanem TI; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.; Department of Hematology, University of Uyo, Uyo 520271, Nigeria.
Tsai WL; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Lin YH; Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.
Tan WQ; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Chang HY; Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.
Huang TC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Chen HY; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Lee KH; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University 11696, Taipei, Taiwan.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Aug 22; Vol. 25 (17). Date of Electronic Publication: 2020 Aug 22.
Typ publikacji :
Journal Article
MeSH Terms :
Aspirin/*pharmacology
Colorectal Neoplasms/*drug therapy
Cytotoxins/*pharmacology
HMGA2 Protein/*antagonists & inhibitors
Neoplasm Proteins/*antagonists & inhibitors
Sulindac/*analogs & derivatives
Cell Movement/drug effects ; Cell Proliferation/drug effects ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; HMGA2 Protein/metabolism ; Humans ; Neoplasm Proteins/metabolism ; Sulindac/pharmacology
Czasopismo naukowe
Tytuł :
[Expression of miRNA let-7a and HMGA2 and Diagnostic Value of Serum miRNA let-7a Level in Pancreatic Cancer].
Autorzy :
Mao XB; The First Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Sheng T; The First Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Zhuang LP; The First Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Wu CK; The First Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Zhao GG; The First Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
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Źródło :
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2020 Jul; Vol. 51 (4), pp. 540-545.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
HMGA2 Protein*/genetics
MicroRNAs*/blood
MicroRNAs*/genetics
Pancreatic Neoplasms*/blood
Pancreatic Neoplasms*/diagnosis
Pancreatic Neoplasms*/genetics
Gene Expression Profiling ; Humans ; RNA, Messenger/genetics
Czasopismo naukowe
Tytuł :
Molecular mechanism of targeted inhibition of HMGA2 via miRNAlet-7a in proliferation and metastasis of laryngeal squamous cell carcinoma.
Autorzy :
Ma LJ; Department of Otolaryngology Head/Neck Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, P. R. China.
Wu J; Department of Otolaryngology Head/Neck Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, P. R. China.
Zhou E; Department of Otolaryngology Head/Neck Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, P. R. China.
Yin J; Department of Otolaryngology Head/Neck Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, P. R. China.
Xiao XP; Department of Otolaryngology Head/Neck Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, P. R. China.
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Źródło :
Bioscience reports [Biosci Rep] 2020 Jun 26; Vol. 40 (6).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement*
Cell Proliferation*
Biomarkers, Tumor/*metabolism
HMGA2 Protein/*metabolism
Laryngeal Neoplasms/*metabolism
MicroRNAs/*metabolism
Squamous Cell Carcinoma of Head and Neck/*metabolism
Animals ; Biomarkers, Tumor/genetics ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; HMGA2 Protein/genetics ; Humans ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/pathology ; Lymphatic Metastasis ; Male ; Mice, Inbred BALB C ; MicroRNAs/genetics ; Middle Aged ; Neoplasm Staging ; Signal Transduction ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/secondary ; Tumor Burden
Czasopismo naukowe
Tytuł :
MiR-26b Suppresses the Development of Stanford Type A Aortic Dissection by Regulating HMGA2 and TGF-β/Smad3 Signaling Pathway.
Autorzy :
Yang P; Department of Vasculocardiology, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Wu P; Department of Vasculocardiology, Ya'an People's Hospital, Ya'an, China.
Liu X; Department of Vasculocardiology, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Feng J; Department of Vasculocardiology, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Zheng S; Department of Vasculocardiology, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Wang Y; Department of Vasculocardiology, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
Fan Z; Department of Vasculocardiology, the Affiliated Hospital of Southwest Medical University, Luzhou, China.; The Key laboratory of Medical Electrophysiology, ministry of Education, Southwest Medical University, Luzhou, China.
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Źródło :
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia [Ann Thorac Cardiovasc Surg] 2020 Jun 20; Vol. 26 (3), pp. 140-150. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji :
Journal Article
MeSH Terms :
Aneurysm, Dissecting/*metabolism
Aortic Aneurysm, Thoracic/*metabolism
HMGA2 Protein/*metabolism
MicroRNAs/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Smad3 Protein/*metabolism
Transforming Growth Factor beta/*metabolism
Adult ; Aneurysm, Dissecting/genetics ; Aneurysm, Dissecting/pathology ; Aneurysm, Dissecting/prevention & control ; Animals ; Aorta, Thoracic/metabolism ; Aorta, Thoracic/pathology ; Aortic Aneurysm, Thoracic/genetics ; Aortic Aneurysm, Thoracic/pathology ; Aortic Aneurysm, Thoracic/prevention & control ; Apoptosis ; Cells, Cultured ; Female ; Gene Expression Regulation ; HMGA2 Protein/genetics ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/pathology ; Phosphorylation ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł :
The Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2): Biochemical and Biophysical Properties, and Its Association with Adipogenesis.
Autorzy :
Su L; Biomolecular Sciences Institute, Department of Chemistry & Biochemistry, Florida International University, Miami, FL 33199, USA.
Deng Z; Biomolecular Sciences Institute, Department of Chemistry & Biochemistry, Florida International University, Miami, FL 33199, USA.
Leng F; Biomolecular Sciences Institute, Department of Chemistry & Biochemistry, Florida International University, Miami, FL 33199, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 May 25; Vol. 21 (10). Date of Electronic Publication: 2020 May 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adipogenesis*
HMGA2 Protein/*chemistry
Animals ; HMGA2 Protein/metabolism ; Humans ; Protein Binding ; Protein Domains
Czasopismo naukowe
Tytuł :
Novel Variants in the HMGA2 Gene Are Associated With Withers Height in Debao Pony.
Autorzy :
Liu S; Equine Center, China Agricultural University, Beijing, China; College of Animal Science and Technology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, Beijing, China; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, Beijing, China.
Jiang S; Equine Center, China Agricultural University, Beijing, China; College of Animal Science and Technology, China Agricultural University, Beijing, China.
Dong XG; Equine Center, China Agricultural University, Beijing, China; College of Animal Science and Technology, China Agricultural University, Beijing, China.
Cui R; Equine Center, China Agricultural University, Beijing, China; College of Animal Science and Technology, China Agricultural University, Beijing, China.
Ling Y; Equine Center, China Agricultural University, Beijing, China; College of Animal Science and Technology, China Agricultural University, Beijing, China.
Zhao C; Equine Center, China Agricultural University, Beijing, China; College of Animal Science and Technology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, Beijing, China; Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, Beijing, China; Beijing Key Laboratory of Animal Genetic Improvement, Beijing, China. Electronic address: .
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Źródło :
Journal of equine veterinary science [J Equine Vet Sci] 2020 May; Vol. 88, pp. 102948. Date of Electronic Publication: 2020 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Body Height*/genetics
HMGA2 Protein*/genetics
Horses*/genetics
Animals ; China ; Exons/genetics ; Humans
Czasopismo naukowe
Tytuł :
Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target.
Autorzy :
Franses JW; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Philipp J; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Missios P; Children's Hospital Boston, Harvard Medical School, Boston, MA, 02115, USA.
Bhan I; Massachusetts General Hospital Division of Gastroenterology, Harvard Medical School, Boston, MA, 02114, USA.
Liu A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Yashaswini C; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Tai E; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Zhu H; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Ligorio M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Nicholson B; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Tassoni EM; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Desai N; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Kulkarni AS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Szabolcs A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Hong TS; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Liss AS; Massachusetts General Hospital Department of Surgery, Harvard Medical School, Boston, MA, 02114, USA.
Fernandez-Del Castillo C; Massachusetts General Hospital Department of Surgery, Harvard Medical School, Boston, MA, 02114, USA.
Ryan DP; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Maheswaran S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.
Haber DA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, 20615, USA.
Daley GQ; Children's Hospital Boston, Harvard Medical School, Boston, MA, 02115, USA.
Ting DT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 03; Vol. 11 (1), pp. 3303. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Carcinoma, Pancreatic Ductal/*genetics
HMGA2 Protein/*genetics
MicroRNAs/*genetics
Neoplastic Cells, Circulating/*metabolism
Pancreatic Neoplasms/*genetics
RNA-Binding Proteins/*genetics
Adult ; Aged ; Animals ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Line, Tumor ; Cell Movement/genetics ; Female ; Gene Expression Regulation, Neoplastic ; HMGA2 Protein/metabolism ; Humans ; Kaplan-Meier Estimate ; Male ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Middle Aged ; Neoplasm Metastasis ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt-PCAF pathway in promotion of esophageal squamous cell carcinoma growth.
Autorzy :
Wu Y; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Wang X; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Xu F; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Zhang L; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Wang T; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Fu X; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Jin T; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Zhang W; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
Ye L; State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, P.R. China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 May 21; Vol. 48 (9), pp. 4858-4876.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Esophageal Neoplasms/*metabolism
Esophageal Squamous Cell Carcinoma/*metabolism
HMGA2 Protein/*metabolism
Acetylation ; Animals ; Aspirin/pharmacology ; Cell Line, Tumor ; DNA/metabolism ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/genetics ; Esophageal Squamous Cell Carcinoma/mortality ; Esophageal Squamous Cell Carcinoma/pathology ; Female ; Gene Expression Regulation, Neoplastic ; HMGA2 Protein/chemistry ; Humans ; Lysine/metabolism ; Mice, Inbred BALB C ; Mice, Nude ; Prognosis ; Protein Binding ; Protein Stability ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Ubiquitination ; p300-CBP Transcription Factors/metabolism
Czasopismo naukowe

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