Temat: "HYDROXYSTEROID dehydrogenases" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Long read sequencing characterises a novel structural variant, revealing underactive AKR1C1 with overactive AKR1C2 as a possible cause of severe chronic fatigue.
Autorzy:: Oakley J; Independent researcher, Hampshire, UK.
Hill M; Department of Steroids and Proteofactors, Institute of Endocrinology, Národni 8, 11694, Prague, Czech Republic.
Giess A; Scientific Research and Development, Genomics England, London, UK.
Tanguy M; Scientific Research and Development, Genomics England, London, UK.
Elgar G; Scientific Research and Development, Genomics England, London, UK. .; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2023 Nov 17; Vol. 21 (1), pp. 825. Date of Electronic Publication: 2023 Nov 17.
Typ publikacji:: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Fatigue Syndrome, Chronic*
Humans ; Tandem Mass Spectrometry ; Biomarkers ; Hydroxysteroid Dehydrogenases

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Skocz do pozycji: 2.

Tytuł:: HSDL2 knockdown promotes the progression of cholangiocarcinoma by inhibiting ferroptosis through the P53/SLC7A11 axis.
Autorzy:: Ma S; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China.; Liver Transplantation Center and Hepatobiliary and Pancreatic Surgery, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Ma Y; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China.
Qi F; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China.
Lei J; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China.
Chen F; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China.
Sun W; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China.
Wang D; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China.
Zhou S; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China.
Liu Z; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China.
Lu Z; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China. .
Zhang D; Department of General Surgery, The First Affiliated Hospital of Bengbu Medical College, NO. 287, Changhuai Road, Longzihu district, Bengbu, 233000, Anhui, China. .; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA. .; Pokaż więcej
Źródło:: World journal of surgical oncology [World J Surg Oncol] 2023 Sep 18; Vol. 21 (1), pp. 293. Date of Electronic Publication: 2023 Sep 18.
Typ publikacji:: Journal Article
MeSH Terms:: Ferroptosis*
Cholangiocarcinoma*/genetics
Bile Duct Neoplasms*/genetics
Humans ; Animals ; Mice ; Tumor Suppressor Protein p53/genetics ; Disease Models, Animal ; Bile Ducts, Intrahepatic ; Amino Acid Transport System y+/genetics ; Hydroxysteroid Dehydrogenases

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Skocz do pozycji: 3.

Tytuł:: AKR1C1/2 inhibition by MPA sensitizes platinum resistant ovarian cancer towards carboplatin.
Autorzy:: Badmann S; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.
Mayr D; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Schmoeckel E; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Hester A; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.
Buschmann C; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.
Beyer S; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.
Kolben T; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.
Kraus F; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.
Chelariu-Raicu A; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.
Burges A; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.
Mahner S; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.
Jeschke U; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.; Department of Obstetrics and Gynecology, University Hospital Augsburg, Augsburg, Germany.
Trillsch F; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany.
Czogalla B; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchioninistr 15, 81377, Munich, Germany. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Feb 03; Vol. 12 (1), pp. 1862. Date of Electronic Publication: 2022 Feb 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: 20-Hydroxysteroid Dehydrogenases/*antagonists & inhibitors
Antineoplastic Agents, Hormonal/*pharmacology
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carboplatin/*pharmacology
Carcinoma, Ovarian Epithelial/*drug therapy
Enzyme Inhibitors/*pharmacology
Hydroxysteroid Dehydrogenases/*antagonists & inhibitors
Medroxyprogesterone Acetate/*pharmacology
Ovarian Neoplasms/*drug therapy
20-Hydroxysteroid Dehydrogenases/metabolism ; Carcinoma, Ovarian Epithelial/enzymology ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Resistance, Neoplasm ; Female ; Humans ; Hydroxysteroid Dehydrogenases/metabolism ; Middle Aged ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Ovarian Neoplasms/enzymology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology

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Skocz do pozycji: 4.

Tytuł:: Resistance to Resveratrol Treatment in Experimental PTSD Is Associated with Abnormalities in Hepatic Metabolism of Glucocorticoids.
Autorzy:: Tseilikman VE; Scientific and Educational Center 'Biomedical Technologies', School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
Fedotova JO; Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology RAS, 6 Emb. Makarova, 199034 Saint Petersburg, Russia.
Tseilikman OB; Scientific and Educational Center 'Biomedical Technologies', School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.; Faculty of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia.
Novak J; Department of Biotechnology, University of Rijeka, 51000 Rijeka, Croatia.; Center for Artificial Intelligence and Cyber Security, University of Rijeka, 51000 Rijeka, Croatia.
Karpenko MN; Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia.
Maistrenko VA; Pavlov Department of Physiology, Institute of Experimental Medicine, 197376 Saint Petersburg, Russia.
Lazuko SS; Department of Physiology, Vitebsk State Medical University, Frunze Av. 27, 210023 Vitebsk, Belarus.
Belyeva LE; Department of Pathophysiology, Vitebsk State Medical University, Frunze Av. 27, 210023 Vitebsk, Belarus.
Kamel M; Research, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B. N. Yeltsin, 620002 Ekaterinburg, Russia.
Buhler AV; Research, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B. N. Yeltsin, 620002 Ekaterinburg, Russia.
Kovaleva EG; Research, Educational and Innovative Center of Chemical and Pharmaceutical Technologies Chemical Technology Institute, Ural Federal University Named after the First President of Russia B. N. Yeltsin, 620002 Ekaterinburg, Russia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 May 26; Vol. 24 (11). Date of Electronic Publication: 2023 May 26.
Typ publikacji:: Journal Article
MeSH Terms:: Glucocorticoids*/pharmacology
Glucocorticoids*/metabolism
Stress Disorders, Post-Traumatic*/drug therapy
Rats ; Humans ; Animals ; Corticosterone ; Resveratrol/pharmacology ; Cytochrome P-450 CYP3A ; 11-beta-Hydroxysteroid Dehydrogenases ; Hydroxysteroid Dehydrogenases/genetics ; Hydroxysteroid Dehydrogenases/metabolism ; 11-beta-Hydroxysteroid Dehydrogenase Type 1

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Skocz do pozycji: 5.

Tytuł:: SRSF3-Mediated Ki67 Exon 7-Inclusion Promotes Head and Neck Squamous Cell Carcinoma Progression via Repressing AKR1C2.
Autorzy:: Liu M; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Lin C; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Huang Q; RNA Institute, Wuhan University, Wuhan 430072, China.; State Key Laboratory of Virology and Hubei Key Laboratory of Cell Homeostasis, College of Life Science, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, China.
Jia J; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.; Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Guo J; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.; Department of Endodontics, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Jia R; The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.; RNA Institute, Wuhan University, Wuhan 430072, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 15; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Transformation, Neoplastic*/genetics
Head and Neck Neoplasms*/genetics
Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Ki-67 Antigen/metabolism ; Exons ; Protein Isoforms/metabolism ; Carcinogenesis/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Cell Proliferation ; Serine-Arginine Splicing Factors/metabolism ; Hydroxysteroid Dehydrogenases/genetics ; Hydroxysteroid Dehydrogenases/metabolism

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Skocz do pozycji: 6.

Tytuł:: Superior mesenteric ganglion via ovarian plexus nerve involved in the cross-talk between noradrenaline and GnRH in rat ovaries.
Autorzy:: Delsouc MB; Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina.
Vallcaneras S; Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina.; Instituto Multidisciplinario de Investigaciones Biológicas de San Luis (IMIBIO-SL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Luis, Argentina.
Daneri Becerra C; Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Mohamed FH; Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina.
Fernández M; Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Vega Orozco AS; Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina.
Casais M; Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina.; Instituto Multidisciplinario de Investigaciones Biológicas de San Luis (IMIBIO-SL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Luis, Argentina.; Pokaż więcej
Źródło:: Systems biology in reproductive medicine [Syst Biol Reprod Med] 2023 Apr; Vol. 69 (2), pp. 87-100. Date of Electronic Publication: 2023 Jan 23.
Typ publikacji:: Journal Article
MeSH Terms:: Ovary*/metabolism
Progesterone*/metabolism
Female ; Rats ; Animals ; Norepinephrine/metabolism ; Norepinephrine/pharmacology ; Gonadotropin-Releasing Hormone/metabolism ; bcl-2-Associated X Protein/metabolism ; bcl-2-Associated X Protein/pharmacology ; Rats, Sprague-Dawley ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Hydroxysteroid Dehydrogenases/metabolism

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Skocz do pozycji: 7.

Tytuł:: Expression Profile of Hydroxysteroid Dehydrogenase-like 2 in Polychaete Perinereis aibuhitensis in Response to BPA.
Autorzy:: Li, Yingpeng (AUTHOR)
Zhao, Huan (AUTHOR)
Pang, Min (AUTHOR)
Huang, Yi (AUTHOR)
Zhang, Boxu (AUTHOR)
Yang, Dazuo (AUTHOR)
Zhou, Yibing (AUTHOR); Pokaż więcej
Źródło:: Life (2075-1729). Jan2023, Vol. 13 Issue 1, p10. 16p.

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Skocz do pozycji: 8.

Tytuł:: Comprehensive analysis regarding the prognostic significance of downregulated ferroptosis-related gene AKR1C2 in gastric cancer and its underlying roles in immune response.
Autorzy:: Liu W; Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.; Department of Orthopedic Surgery, The Second Hospital University of South China, Hengyang, China.
Zhang F; Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yang K; Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
Yan Y; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Jan 26; Vol. 18 (1), pp. e0280989. Date of Electronic Publication: 2023 Jan 26 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Stomach Neoplasms*/genetics
Ferroptosis*/genetics
Humans ; Prognosis ; Carcinogenesis ; Immunity ; Hydroxysteroid Dehydrogenases

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Skocz do pozycji: 9.

Tytuł:: HB-EGF upregulates StAR expression and stimulates progesterone production through ERK1/2 signaling in human granulosa-lutein cells.
Autorzy:: Cheng JC; Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 40, Daxue Road, Zhengzhou, Henan, China. .
Han X; Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 40, Daxue Road, Zhengzhou, Henan, China.
Meng Q; Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 40, Daxue Road, Zhengzhou, Henan, China.
Guo Y; Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 40, Daxue Road, Zhengzhou, Henan, China.
Liu B; Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 40, Daxue Road, Zhengzhou, Henan, China.
Song T; Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 40, Daxue Road, Zhengzhou, Henan, China.
Jia Y; Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 40, Daxue Road, Zhengzhou, Henan, China.
Fang L; Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 40, Daxue Road, Zhengzhou, Henan, China.
Sun YP; Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 40, Daxue Road, Zhengzhou, Henan, China. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2022 Oct 25; Vol. 20 (1), pp. 166. Date of Electronic Publication: 2022 Oct 25.
Typ publikacji:: Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Luteal Cells*/metabolism
Female ; Humans ; Progesterone/metabolism ; Aromatase/metabolism ; Aromatase/pharmacology ; Amphiregulin/metabolism ; Amphiregulin/pharmacology ; Epidermal Growth Factor/pharmacology ; Heparin-binding EGF-like Growth Factor/metabolism ; Heparin-binding EGF-like Growth Factor/pharmacology ; MAP Kinase Signaling System ; RNA, Small Interfering/metabolism ; Ligands ; Lutein/metabolism ; Lutein/pharmacology ; Phosphoproteins/metabolism ; Signal Transduction ; ErbB Receptors/metabolism ; Hydroxysteroid Dehydrogenases/metabolism ; Hydroxysteroid Dehydrogenases/pharmacology ; Heparin/metabolism ; Heparin/pharmacology ; Granulosa Cells/metabolism ; Cells, Cultured

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Skocz do pozycji: 10.

Tytuł:: Functional Characterization and Synthetic Application of Is2-SDR, a Novel Thermostable and Promiscuous Ketoreductase from a Hot Spring Metagenome.
Autorzy:: Ferrandi, Erica Elisa (AUTHOR)
Bassanini, Ivan (AUTHOR)
Bertuletti, Susanna (AUTHOR)
Riva, Sergio (AUTHOR)
Tognoli, Chiara (AUTHOR)
Vanoni, Marta (AUTHOR)
Monti, Daniela (AUTHOR); Pokaż więcej
Źródło:: International Journal of Molecular Sciences. Oct2022, Vol. 23 Issue 20, p12153-N.PAG. 19p.

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Skocz do pozycji: 11.

Tytuł:: Seasonal dynamics, kinetics, and effects of 2-hydroxyestradiol-17β on some steroidogenic enzymes in the ovary of the catfish Heteropneustes fossilis.
Autorzy:: Chourasia, Tapan Kumar
Chaube, Radha
Joy, Keerikkattil Paily; Pokaż więcej
Źródło:: Aquaculture & Fisheries (2096-1758). Sep2022, Vol. 7 Issue 5, p462-473. 12p.

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Skocz do pozycji: 12.

Tytuł:: Promiscuity and Selectivity of Hydroxysteroid Dehydrogenases in the Biocatalyzed Reduction of 1,2‐Diketones.
Autorzy:: Tognoli, Chiara (AUTHOR)
Bertuletti, Susanna (AUTHOR)
Patti, Stefania (AUTHOR)
Ferrandi, Erica Elisa (AUTHOR)
Vanoni, Marta (AUTHOR)
Riva, Sergio (AUTHOR)
Bassanini, Ivan (AUTHOR)
Monti, Daniela (AUTHOR); Pokaż więcej
Źródło:: ChemCatChem. 12/19/2023, Vol. 15 Issue 24, p1-9. 9p.

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Skocz do pozycji: 13.

Tytuł:: Early exposure to paracetamol reduces level of testicular testosterone and changes gonadal expression of genes relevant for steroidogenesis in rats offspring.
Autorzy:: Blecharz-Klin, Kamilla (AUTHOR)
Sznejder-Pachołek, Anna (AUTHOR)
Wawer, Adriana (AUTHOR)
Pyrzanowska, Justyna (AUTHOR)
Piechal, Agnieszka (AUTHOR)
Joniec-Maciejak, Ilona (AUTHOR)
Mirowska-Guzel, Dagmara (AUTHOR)
Widy-Tyszkiewicz, Ewa (AUTHOR); Pokaż więcej
Źródło:: Drug & Chemical Toxicology. Jul2022, Vol. 45 Issue 4, p1862-1869. 8p.

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Skocz do pozycji: 14.

Tytuł:: Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation.
Autorzy:: Horváth G; Laboratory for NMR Spectroscopy, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 2 Magyar tudósok körútja, H-1117, Budapest, Hungary.
Egyed O; Laboratory for NMR Spectroscopy, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 2 Magyar tudósok körútja, H-1117, Budapest, Hungary.
Tang C; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri, 63110, USA.
Kovács M; Department of Biochemistry, ELTE-MTA 'Momentum' Motor Enzymology Research Group, Eötvös Loránd University, Pázmány Péter sétány 1/C, H-1117, Budapest, Hungary.
Micsonai A; Department of Biochemistry, MTA-ELTE NAP B Neuroimmunology Research Group, Institute of Biology, Eötvös Loránd University, Pázmány Péter sétány 1/C, H-1117, Budapest, Hungary.
Kardos J; Department of Biochemistry, MTA-ELTE NAP B Neuroimmunology Research Group, Institute of Biology, Eötvös Loránd University, Pázmány Péter sétány 1/C, H-1117, Budapest, Hungary.
Toke O; Laboratory for NMR Spectroscopy, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 2 Magyar tudósok körútja, H-1117, Budapest, Hungary. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Mar 18; Vol. 9 (1), pp. 4825. Date of Electronic Publication: 2019 Mar 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Protons*
Bile Acids and Salts/*metabolism
Histidine/*metabolism
Hydroxysteroid Dehydrogenases/*metabolism
Allosteric Regulation ; Bile Acids and Salts/chemistry ; Helix-Loop-Helix Motifs ; Hydrogen Bonding ; Hydrogen-Ion Concentration ; Hydroxysteroid Dehydrogenases/chemistry ; Hydroxysteroid Dehydrogenases/ultrastructure ; Kinetics ; Ligands ; Molecular Dynamics Simulation ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Structure, Secondary

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Skocz do pozycji: 15.

Tytuł:: Enhanced activity and substrate tolerance of 7α-hydroxysteroid dehydrogenase by directed evolution for 7-ketolithocholic acid production.
Autorzy:: Huang B; Hunan Flag Bio-tech Co., Ltd., Changsha, 410100, China. .
Zhao Q; Hunan Flag Bio-tech Co., Ltd., Changsha, 410100, China.
Zhou JH; Hunan Flag Bio-tech Co., Ltd., Changsha, 410100, China.
Xu G; Hunan Flag Bio-tech Co., Ltd., Changsha, 410100, China.; College of Life Science and Technology, Central South University of Forestry and Technology, Changsha, 410004, China.; Pokaż więcej
Źródło:: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2019 Mar; Vol. 103 (6), pp. 2665-2674. Date of Electronic Publication: 2019 Feb 07.
Typ publikacji:: Journal Article
MeSH Terms:: Directed Molecular Evolution*
Clostridium/*enzymology
Hydroxysteroid Dehydrogenases/*metabolism
Lithocholic Acid/*analogs & derivatives
Clostridium/genetics ; Escherichia coli/genetics ; High-Throughput Screening Assays ; Hydroxysteroid Dehydrogenases/genetics ; Kinetics ; Lithocholic Acid/biosynthesis ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Ursodeoxycholic Acid/metabolism

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Skocz do pozycji: 16.

Tytuł:: Synthesis of ω‐Muricholic Acid by One‐Pot Enzymatic Mitsunobu Inversion using Hydroxysteroid Dehydrogenases.
Autorzy:: Bertuletti, Susanna (AUTHOR)
Ferrandi, Erica Elisa (AUTHOR)
Monti, Daniela (AUTHOR)
Fronza, Giovanni (AUTHOR)
Bassanini, Ivan (AUTHOR)
Riva, Sergio (AUTHOR); Pokaż więcej
Źródło:: ChemCatChem. 12/7/2021, Vol. 13 Issue 23, p4948-4953. 6p.

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Skocz do pozycji: 17.

Tytuł:: Antioxidant and anti-inflammatory protective effects of rutin and kolaviron against busulfan-induced testicular injuries in rats.
Autorzy:: Abarikwu SO; Department of Biochemistry, University of Port Harcourt, Choba, Nigeria.
Njoku RC; Department of Chemistry/Biochemistry & Molecular Biology, Alex Ekwueme-Federal University Ndufu-Alike, Ikwo, Nigeria.
John IG; Department of Biochemistry, University of Port Harcourt, Choba, Nigeria.
Amadi BA; Department of Biochemistry, University of Port Harcourt, Choba, Nigeria.
Mgbudom-Okah CJ; Department of Biochemistry, University of Port Harcourt, Choba, Nigeria.
Onuah CL; Department of Biochemistry, University of Port Harcourt, Choba, Nigeria.; Pokaż więcej
Źródło:: Systems biology in reproductive medicine [Syst Biol Reprod Med] 2022 Apr; Vol. 68 (2), pp. 151-161. Date of Electronic Publication: 2021 Nov 09.
Typ publikacji:: Journal Article
MeSH Terms:: Antioxidants*/metabolism
Antioxidants*/pharmacology
Rutin*/pharmacology
Rutin*/therapeutic use
Animals ; Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Busulfan/toxicity ; Flavonoids ; Glutathione/metabolism ; Glutathione/pharmacology ; Hydroxysteroid Dehydrogenases/metabolism ; Male ; Necrosis/metabolism ; Necrosis/pathology ; Oxidative Stress ; Peroxidase/metabolism ; Peroxidase/pharmacology ; Rats ; Rats, Wistar ; Testis

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Skocz do pozycji: 18.

Tytuł:: Molecular interactions of bisphenols and analogs with glucocorticoid biosynthetic pathway enzymes: an in silico approach.
Autorzy:: Verma G; a Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Jamia Hamdard , New Delhi , India.
Khan MF; a Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Jamia Hamdard , New Delhi , India.
Akhtar W; a Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Jamia Hamdard , New Delhi , India.
Alam MM; a Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Jamia Hamdard , New Delhi , India.
Akhter M; a Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Jamia Hamdard , New Delhi , India.
Shaquiquzzaman M; a Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Jamia Hamdard , New Delhi , India.; Pokaż więcej
Źródło:: Toxicology mechanisms and methods [Toxicol Mech Methods] 2018 Jan; Vol. 28 (1), pp. 45-54. Date of Electronic Publication: 2017 Aug 03.
Typ publikacji:: Journal Article
MeSH Terms:: Molecular Docking Simulation*
Benzhydryl Compounds/*toxicity
Cytochrome P-450 Enzyme Inhibitors/*toxicity
Cytochrome P-450 Enzyme System/*metabolism
Endocrine Disruptors/*toxicity
Environmental Pollutants/*toxicity
Glucocorticoids/*biosynthesis
Hydroxysteroid Dehydrogenases/*antagonists & inhibitors
Phenols/*toxicity
Benzhydryl Compounds/chemistry ; Benzhydryl Compounds/metabolism ; Binding Sites ; Cytochrome P-450 Enzyme Inhibitors/chemistry ; Cytochrome P-450 Enzyme Inhibitors/metabolism ; Cytochrome P-450 Enzyme System/chemistry ; Endocrine Disruptors/chemistry ; Endocrine Disruptors/metabolism ; Environmental Pollutants/chemistry ; Environmental Pollutants/metabolism ; Hydroxysteroid Dehydrogenases/chemistry ; Hydroxysteroid Dehydrogenases/metabolism ; Ligands ; Phenols/chemistry ; Phenols/metabolism ; Protein Binding ; Protein Conformation ; Risk Assessment ; Structure-Activity Relationship

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Tytuł:: Structure of NADP -bound 7β-hydroxysteroid dehydrogenase reveals two cofactor-binding modes.
Autorzy:: Wang R; Wuxi Biortus Biosciences Co. Ltd, A5, 6 Dongsheng West Road, 214437 Jiangyin, Jiangsu, People's Republic of China.
Wu J; Wuxi Biortus Biosciences Co. Ltd, A5, 6 Dongsheng West Road, 214437 Jiangyin, Jiangsu, People's Republic of China.
Jin DK; Wuxi Biortus Biosciences Co. Ltd, A5, 6 Dongsheng West Road, 214437 Jiangyin, Jiangsu, People's Republic of China.
Chen Y; Wuxi Biortus Biosciences Co. Ltd, A5, 6 Dongsheng West Road, 214437 Jiangyin, Jiangsu, People's Republic of China.
Lv Z; Wuxi Biortus Biosciences Co. Ltd, A5, 6 Dongsheng West Road, 214437 Jiangyin, Jiangsu, People's Republic of China.
Chen Q; Wuxi Biortus Biosciences Co. Ltd, A5, 6 Dongsheng West Road, 214437 Jiangyin, Jiangsu, People's Republic of China.
Miao Q; Wuxi Biortus Biosciences Co. Ltd, A5, 6 Dongsheng West Road, 214437 Jiangyin, Jiangsu, People's Republic of China.
Huo X; Wuxi Biortus Biosciences Co. Ltd, A5, 6 Dongsheng West Road, 214437 Jiangyin, Jiangsu, People's Republic of China.
Wang F; Wuxi Biortus Biosciences Co. Ltd, A5, 6 Dongsheng West Road, 214437 Jiangyin, Jiangsu, People's Republic of China.; Pokaż więcej
Źródło:: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2017 May 01; Vol. 73 (Pt 5), pp. 246-252. Date of Electronic Publication: 2017 Apr 26.
Typ publikacji:: Journal Article
MeSH Terms:: Actinobacteria/*chemistry
Bacterial Proteins/*chemistry
Hydroxysteroid Dehydrogenases/*chemistry
NADP/*chemistry
Ursodeoxycholic Acid/*chemistry
Actinobacteria/enzymology ; Amino Acid Sequence ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Catalytic Domain ; Cloning, Molecular ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Hydroxysteroid Dehydrogenases/genetics ; Hydroxysteroid Dehydrogenases/metabolism ; Models, Molecular ; NADP/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Ursodeoxycholic Acid/metabolism