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Wyszukujesz frazę ""HYPOGLYCEMIC agents"" wg kryterium: Temat


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Tytuł :
Plant polypeptides: A review on extraction, isolation, bioactivities and prospects.
Autorzy :
Wang W; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Liu Z; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Liu Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Su Z; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
Liu Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2022 May 15; Vol. 207, pp. 169-178. Date of Electronic Publication: 2022 Mar 04.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hypoglycemic Agents*/chemistry
Hypoglycemic Agents*/pharmacology
Hypoglycemic Agents*/therapeutic use
Medicine, Chinese Traditional*/methods
Anti-Bacterial Agents/chemistry ; China ; Peptides/pharmacology ; Plant Extracts/chemistry
Czasopismo naukowe
Tytuł :
Purification and characterization of hypoglycemic peptides from traditional Chinese soy-fermented douchi .
Autorzy :
Yu S; Zhejiang Key Laboratory for Agro-Food Processing, College of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China. .
Liu L; Zhejiang Key Laboratory for Agro-Food Processing, College of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China. .
Bu T; Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou, 310014, China.
Zheng J; Zhejiang Key Laboratory for Agro-Food Processing, College of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China. .
Wang W; Zhejiang Key Laboratory for Agro-Food Processing, College of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China. .; National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang R & D Center for Food Technology and Equipment, Fuli Institute of Food Science, Ningbo Research Institute, Zhejiang University, Hangzhou, 310058, China.
Wu J; Department of Agricultural, Food and Nutritional Science, 4-10 Ag/For Building, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada. .
Liu D; Zhejiang Key Laboratory for Agro-Food Processing, College of Biosystems Engineering and Food Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China. .; National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang R & D Center for Food Technology and Equipment, Fuli Institute of Food Science, Ningbo Research Institute, Zhejiang University, Hangzhou, 310058, China.
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Źródło :
Food & function [Food Funct] 2022 Mar 21; Vol. 13 (6), pp. 3343-3352. Date of Electronic Publication: 2022 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Fermented Foods*
Glucose/*metabolism
Hypoglycemic Agents/*isolation & purification
Myoblasts/*metabolism
Peptides/*isolation & purification
AMP-Activated Protein Kinases/metabolism ; Amino Acid Sequence ; Animals ; Cell Line ; Glucose Transporter Type 4/metabolism ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/pharmacology ; Insulin/metabolism ; MAP Kinase Signaling System ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Skeletal/metabolism ; Myoblasts/drug effects ; Peptides/chemistry ; Peptides/pharmacology ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł :
Exploring the synergistic and complementary effects of berberine and paeoniflorin in the treatment of type 2 diabetes mellitus by network pharmacology.
Autorzy :
Zhang L; Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Han L; Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Ma J; Guangwai Hospital, Xicheng District, Beijing, 100053, China.
Wu T; Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China.
Wei Y; Graduate College, Beijing University of Traditional Chinese Medicine, Beijing, 100029, China.
Zhao L; Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. Electronic address: .
Tong X; Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, 130021, China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2022 Mar 15; Vol. 919, pp. 174769. Date of Electronic Publication: 2022 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Berberine/*pharmacology
Diabetes Mellitus, Type 2/*drug therapy
Drugs, Chinese Herbal/*pharmacology
Glucosides/*pharmacology
Hypoglycemic Agents/*pharmacology
Monoterpenes/*pharmacology
Animals ; Berberine/chemistry ; Berberine/therapeutic use ; Blood Glucose/drug effects ; Disease Models, Animal ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; Glucosides/chemistry ; Glucosides/therapeutic use ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Monoterpenes/chemistry ; Monoterpenes/therapeutic use ; Network Pharmacology ; Phytotherapy
Czasopismo naukowe
Tytuł :
Hypoglycemic effect of a novel polysaccharide from Lentinus edodes on STZ-induced diabetic mice via metabolomics study and Nrf2/HO-1 pathway.
Autorzy :
Gong P; School of Food and biotechnological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China. .
Wang X; School of Food and biotechnological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China. .
Liu M; School of Food and biotechnological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China. .
Wang M; School of Food and biotechnological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China. .
Wang S; School of Food and biotechnological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China. .
Guo Y; School of Food and biotechnological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China. .
Chang X; School of Food and biotechnological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China. .
Yang W; School of Food and biotechnological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China. .
Chen X; School of Food and biotechnological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China. .
Chen F; School of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, Xi'an, 710054, China. .
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Źródło :
Food & function [Food Funct] 2022 Mar 07; Vol. 13 (5), pp. 3036-3049. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Shiitake Mushrooms*
Hypoglycemic Agents/*pharmacology
Polysaccharides/*pharmacology
Animals ; Animals, Outbred Strains ; Diabetes Mellitus, Experimental/prevention & control ; Diabetes Mellitus, Type 2/prevention & control ; Diet, High-Fat ; Disease Models, Animal ; Fruit ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/chemistry ; Male ; Mice ; NF-E2-Related Factor 2/metabolism ; Polysaccharides/administration & dosage ; Polysaccharides/chemistry ; Specific Pathogen-Free Organisms ; Streptozocin
SCR Organism :
Kunming mice
Czasopismo naukowe
Tytuł :
Sargassum fusiforme polysaccharide is a potential auxiliary substance for metformin in the management of diabetes.
Autorzy :
Wu J; Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, China. .; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Jia RB; Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, China. .; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Luo D; Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, China. .; School of Food Science and Engineering, Guangdong Ocean University, Yangjiang 529500, China.
Li ZR; Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, China. .; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Lin L; Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, China. .; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Zheng Q; Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, China. .; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
Zhao M; Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, China. .; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
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Źródło :
Food & function [Food Funct] 2022 Mar 07; Vol. 13 (5), pp. 3023-3035. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Sargassum*
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*pharmacology
Metformin/*pharmacology
Polysaccharides/*pharmacology
Animals ; Blood Glucose/drug effects ; Diabetes Mellitus, Experimental/prevention & control ; Diet, High-Fat ; Disease Models, Animal ; Drug Therapy, Combination ; Gastrointestinal Microbiome/drug effects ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/therapeutic use ; Male ; Metformin/chemistry ; Metformin/therapeutic use ; Polysaccharides/chemistry ; Polysaccharides/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Streptozocin
Czasopismo naukowe
Tytuł :
The impact of a novel Chinese yam -derived polysaccharide on blood glucose control in HFD and STZ-induced diabetic C57BL/6 mice.
Autorzy :
Feng X; 'State Key Laboratory of Food Nutrition and Safety', Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin, 300457, People Republic of China. .
Zhang Q; 'State Key Laboratory of Food Nutrition and Safety', Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin, 300457, People Republic of China. .
Li J; 'State Key Laboratory of Food Nutrition and Safety', Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin, 300457, People Republic of China. .
Bie N; 'State Key Laboratory of Food Nutrition and Safety', Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin, 300457, People Republic of China. .
Li C; 'State Key Laboratory of Food Nutrition and Safety', Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin, 300457, People Republic of China. .
Lian R; 'State Key Laboratory of Food Nutrition and Safety', Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin, 300457, People Republic of China. .
Qin L; 'State Key Laboratory of Food Nutrition and Safety', Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin, 300457, People Republic of China. .
Feng Y; 'State Key Laboratory of Food Nutrition and Safety', Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin, 300457, People Republic of China. .
Wang C; 'State Key Laboratory of Food Nutrition and Safety', Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, Tianjin Economy Technological Development Area, Tianjin, 300457, People Republic of China. .
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Źródło :
Food & function [Food Funct] 2022 Mar 07; Vol. 13 (5), pp. 2681-2692. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Dioscorea*
Functional Food*
Antihypertensive Agents/*pharmacology
Drugs, Chinese Herbal/*pharmacology
Hypoglycemic Agents/*pharmacology
Polysaccharides/*pharmacology
Animals ; Antihypertensive Agents/chemistry ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Diabetes Mellitus, Experimental/prevention & control ; Diet, High-Fat ; Disease Models, Animal ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; Glycemic Control ; Hyperglycemia/prevention & control ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Polysaccharides/chemistry ; Specific Pathogen-Free Organisms ; Streptozocin
Czasopismo naukowe
Tytuł :
Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Autorzy :
Ma T; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Tian X; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Zhang B; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Li M; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Wang Y; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Yang C; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Wu J; Laboratory Animal Research Centre, Xiamen University, Fujian, China.
Wei X; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Qu Q; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Yu Y; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Long S; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Feng JW; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Li C; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Zhang C; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Xie C; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Wu Y; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Xu Z; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Chen J; Analysis and Measurement Centre, School of Pharmaceutical Sciences, Xiamen University, Fujian, China.
Yu Y; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Huang X; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
He Y; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Yao L; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Zhang L; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Zhu M; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Wang W; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Liaoning, China.
Wang ZC; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Liaoning, China.
Zhang M; Department of Endocrinology and Metabolism, Shanghai Clinical Centre for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Bao Y; Department of Endocrinology and Metabolism, Shanghai Clinical Centre for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Jia W; Department of Endocrinology and Metabolism, Shanghai Clinical Centre for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Lin SY; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Ye Z; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China.
Piao HL; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Liaoning, China.
Deng X; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China. .
Zhang CS; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China. .
Lin SC; State Key Laboratory for Cellular Stress Biology, Innovation Centre for Cell Signalling Network, School of Life Sciences, Xiamen University, Fujian, China. .
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Źródło :
Nature [Nature] 2022 Mar; Vol. 603 (7899), pp. 159-165. Date of Electronic Publication: 2022 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypoglycemic Agents*/administration & dosage
Hypoglycemic Agents*/metabolism
Hypoglycemic Agents*/pharmacology
Metformin*/agonists
Metformin*/metabolism
Metformin*/pharmacology
Vacuolar Proton-Translocating ATPases*/metabolism
AMP-Activated Protein Kinases/metabolism ; Adenosine Triphosphatases/metabolism ; Amyloid Precursor Protein Secretases ; Animals ; Caenorhabditis elegans/metabolism ; Diabetes Mellitus/drug therapy ; Glucose/metabolism ; Humans ; Lysosomes/metabolism ; Membrane Proteins
Czasopismo naukowe
Tytuł :
Comparisons of efficacy and safety in insulin glargine and lixisenatide plus glulisine combination therapy with multiple daily injection therapy in Japanese patients with type 2 diabetes.
Autorzy :
Kawaguchi Y; Department of Internal Medicine, Minami Osaka Hospital, Osaka, Japan.
Miyamoto S; Department of Internal Medicine, Minami Osaka Hospital, Osaka, Japan.
Hajika Y; Department of Internal Medicine, Minami Osaka Hospital, Osaka, Japan.
Ashida N; Department of Internal Medicine, Minami Osaka Hospital, Osaka, Japan.
Masumoto K; Department of Internal Medicine, Minami Osaka Hospital, Osaka, Japan.
Sawa J; Department of Internal Medicine, Minami Osaka Hospital, Osaka, Japan.
Hamazaki K; Department of Internal Medicine, Minami Osaka Hospital, Osaka, Japan.
Kumeda Y; Department of Internal Medicine, Minami Osaka Hospital, Osaka, Japan.
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Źródło :
Journal of diabetes investigation [J Diabetes Investig] 2022 Mar; Vol. 13 (3), pp. 505-514. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Diabetes Mellitus, Type 2*/drug therapy
Hypoglycemic Agents*/administration & dosage
Hypoglycemic Agents*/therapeutic use
Insulin Glargine*/adverse effects
Insulin Glargine*/therapeutic use
Blood Glucose ; Blood Glucose Self-Monitoring ; Glycated Hemoglobin A/analysis ; Humans ; Insulin/adverse effects ; Insulin/therapeutic use ; Japan ; Peptides
Czasopismo naukowe
Tytuł :
Glucokinase activation leads to an unsustained hypoglycaemic effect with hepatic triglyceride accumulation in db/db mice.
Autorzy :
Kawata S; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Nakamura A; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Miyoshi H; Division of Diabetes and Obesity, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Yang K; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Shigesawa I; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Yamauchi Y; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Tsuchida K; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Omori K; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Takahashi K; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Nomoto H; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Kameda H; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Cho KY; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.; Clinical Research and Medical Innovation Centre, Hokkaido University Hospital, Sapporo, Japan.
Terauchi Y; Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Atsumi T; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
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Źródło :
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2022 Mar; Vol. 24 (3), pp. 391-401. Date of Electronic Publication: 2021 Nov 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucokinase*/genetics
Glucokinase*/metabolism
Hypoglycemic Agents*/metabolism
Hypoglycemic Agents*/pharmacology
Hypoglycemic Agents*/therapeutic use
Animals ; Gluconeogenesis ; Humans ; Liver/metabolism ; Mice ; Triglycerides/metabolism
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of glucagon-like peptide-1 analogs with the C-terminal helix 3 of albumin-binding domain 3.
Autorzy :
Zhang J; China State Institute of Pharmaceutical Industry, Shanghai, China; Department of Biological Medicines & Shanghai Engineering Research Centre of Immunotherapeutics, Fudan University School of Pharmacy, Shanghai, China.
Li S; China State Institute of Pharmaceutical Industry, Shanghai, China; Shanghai Duomirui Biotechnology Ltd., Shanghai, China.
Dong Y; China State Institute of Pharmaceutical Industry, Shanghai, China; Shanghai Duomirui Biotechnology Ltd., Shanghai, China.
Tang H; Shanghai Duomirui Biotechnology Ltd., Shanghai, China.
He Y; Shanghai Duomirui Biotechnology Ltd., Shanghai, China.
Hu H; China State Institute of Pharmaceutical Industry, Shanghai, China. Electronic address: .
Feng J; China State Institute of Pharmaceutical Industry, Shanghai, China; Shanghai Duomirui Biotechnology Ltd., Shanghai, China. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 May 15; Vol. 62, pp. 116725. Date of Electronic Publication: 2022 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon-Like Peptide 1*
Hypoglycemic Agents*/chemistry
Albumins ; Glucagon-Like Peptide-1 Receptor ; Glucose ; Glucose Tolerance Test
Czasopismo naukowe
Tytuł :
Mutagenicity and safety pharmacology of a standardized antidiabetic polyherbal formulation.
Autorzy :
Abdul Majid FA; Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia. .
Fadhlina A; Institute of Food Security and Sustainable Agriculture, Universiti Malaysia Kelantan, Jeli campus, 17600, Jeli, Kelantan, Malaysia.
Ismail HF; Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.
Zainol SN; Proliv Life Sciences Sdn Bhd, D-1-15, Residensi Bistaria, Jln Ulu Kelang, Taman Ukay Bistari, 68000, Ampang, Selangor, Malaysia.
Mamillapalli AK; Aurigene Pharmaceutical Services Limited, Bollaram Road, Miyapur, Hyderabad, Telangana, 500 049, India.
Venkatesan V; Aurigene Pharmaceutical Services Limited, Bollaram Road, Miyapur, Hyderabad, Telangana, 500 049, India.
Eswarappa R; Aurigene Pharmaceutical Services Limited, Bollaram Road, Miyapur, Hyderabad, Telangana, 500 049, India.
Pillai R; Aurigene Pharmaceutical Services Limited, Bollaram Road, Miyapur, Hyderabad, Telangana, 500 049, India.
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Źródło :
Scientific reports [Sci Rep] 2022 May 03; Vol. 12 (1), pp. 7127. Date of Electronic Publication: 2022 May 03.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoglycemic Agents*/toxicity
Mutagens*/toxicity
Animals ; HEK293 Cells ; Humans ; Mutagenicity Tests ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Factors associated with early nonpersistence among patients experiencing side effects from a new medication.
Autorzy :
Alefan Q
Yao S
Taylor JG
Lix LM
Eurich D
Choudhry N
Blackburn DF
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Źródło :
Journal of the American Pharmacists Association : JAPhA [J Am Pharm Assoc (2003)] 2022 May-Jun; Vol. 62 (3), pp. 717-726.e5. Date of Electronic Publication: 2021 Dec 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antihypertensive Agents*/adverse effects
Hypoglycemic Agents*/adverse effects
Aged ; Canada ; Female ; Humans ; Logistic Models ; Medication Adherence ; Odds Ratio
Czasopismo naukowe
Tytuł :
Integrative Analysis of Randomized Clinical Trial and Observational Study Data to Inform Post-marketing Safety Decision-Making.
Autorzy :
Lin LA; Clinical Safety Statistics, Merck & Co., Inc, Kenilworth, NJ, USA. .
Zhang Y; Clinical Safety Statistics, Merck & Co., Inc, Kenilworth, NJ, USA.
Straus W; Clinical Safety, Moderna, Cambridge, MA, USA.
Wang W; Clinical Safety Statistics, Merck & Co., Inc, Kenilworth, NJ, USA.
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Źródło :
Therapeutic innovation & regulatory science [Ther Innov Regul Sci] 2022 May; Vol. 56 (3), pp. 423-432. Date of Electronic Publication: 2022 Feb 09.
Typ publikacji :
Journal Article; Observational Study; Randomized Controlled Trial
MeSH Terms :
Hypoglycemic Agents*
Research Design*
Humans ; Marketing
Czasopismo naukowe
Tytuł :
Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis.
Autorzy :
Lin Y; Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian 350001, China; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, 88 Jiaotong Road, Fuzhou, Fujian 350001, China.
Dai X; Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian 350001, China; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, 88 Jiaotong Road, Fuzhou, Fujian 350001, China; Fujian Key Laboratory of Vascular Aging, Fujian Medical University, 88 Jiaotong Road, Fuzhou, Fujian 350001, China.
Zhang J; Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian 350001, China; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, 88 Jiaotong Road, Fuzhou, Fujian 350001, China; Fujian Key Laboratory of Vascular Aging, Fujian Medical University, 88 Jiaotong Road, Fuzhou, Fujian 350001, China. Electronic address: .
Chen X; Department of Neurology and Geriatrics, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian 350001, China; Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, 88 Jiaotong Road, Fuzhou, Fujian 350001, China. Electronic address: .
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Źródło :
Behavioural brain research [Behav Brain Res] 2022 Apr 09; Vol. 423, pp. 113772. Date of Electronic Publication: 2022 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apolipoprotein E4*
Organelle Biogenesis*
Aging/*drug effects
Depression/*drug therapy
Glucose/*metabolism
Hypoglycemic Agents/*pharmacology
Metformin/*pharmacology
Aging/metabolism ; Animals ; Apolipoprotein E3 ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Depression/metabolism ; Disease Models, Animal ; Hypoglycemic Agents/administration & dosage ; Metformin/administration & dosage ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Convergent synthesis of (+)-carambolaflavone A, an antidiabetic agent using a bismuth triflate-catalyzed C -aryl glycosylation.
Autorzy :
Ghosh AK; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA. .
Robinson WL; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA. .
Gulliver J; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA. .
Simpson HM; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA. .
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Źródło :
Organic & biomolecular chemistry [Org Biomol Chem] 2022 Apr 06; Vol. 20 (14), pp. 2822-2830. Date of Electronic Publication: 2022 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Galactose*
Hypoglycemic Agents*/pharmacology
Catalysis ; Flavonoids ; Glycosides ; Glycosylation ; Mesylates
Czasopismo naukowe
Tytuł :
Hantzsch condensation reaction as a spectrofluorometric method for determination of alogliptin, an antidiabetic drug, in pure form, tablet form, and human and rat plasma.
Autorzy :
Tammam AS; Chemistry Department, Faculty of Science, Al-Azhar University, Assiut, Egypt.
Gahlan AA; Chemistry Department, Faculty of Science, Al-Azhar University, Assiut, Egypt.
Taher MA; Chemistry Department, Faculty of Science, Al-Azhar University, Assiut, Egypt.
Haredy AM; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Merit University, New Sohag, Egypt.
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Źródło :
Luminescence : the journal of biological and chemical luminescence [Luminescence] 2022 Apr; Vol. 37 (4), pp. 543-550. Date of Electronic Publication: 2022 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoglycemic Agents*
Piperidines*
Animals ; Humans ; Rats ; Spectrometry, Fluorescence/methods ; Tablets ; Uracil/analogs & derivatives
Czasopismo naukowe
Tytuł :
Long-term safety and efficacy of imeglimin as monotherapy or in combination with existing antidiabetic agents in Japanese patients with type 2 diabetes (TIMES 2): A 52-week, open-label, multicentre phase 3 trial.
Autorzy :
Dubourg J; Poxel SA, Lyon, France.
Fouqueray P; Poxel SA, Lyon, France.
Quinslot D; Poxel SA, Lyon, France.
Grouin JM; University of Rouen, Mont Saint Aignan, France.
Kaku K; Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan.
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Źródło :
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2022 Apr; Vol. 24 (4), pp. 609-619. Date of Electronic Publication: 2021 Dec 27.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2*/drug therapy
Hypoglycemic Agents*/adverse effects
Triazines*/adverse effects
Double-Blind Method ; Drug Therapy, Combination/adverse effects ; Humans ; Japan ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Clinical Effects of Exercise Rehabilitation Combined with Repaglinide in the Treatment of Diabetes.
Autorzy :
Li Y; Department of Nursing, China-Japan Union Hospital of Jilin University, Changchun, China.
Wang X; Department of Gynecology, China-Japan Union Hospital of Jilin University, Changchun, China.
Zhang Y; Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China.
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Źródło :
Disease markers [Dis Markers] 2022 Mar 25; Vol. 2022, pp. 6309188. Date of Electronic Publication: 2022 Mar 25 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2*
Hypoglycemic Agents*/therapeutic use
Carbamates/pharmacology ; Carbamates/therapeutic use ; Humans ; Piperidines ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Screening and identification of a novel antidiabetic peptide from collagen hydrolysates of Chinese giant salamander skin: network pharmacology, inhibition kinetics and protection of IR-HepG2 cells.
Autorzy :
Zhou M; College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China. .
Ren G; College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China. .; Henan Engineering Research Center of Food Material, Luoyang 471023, China.; National Demonstration Center for Experimental Food Processing and Safety Education, Luoyang, 471023, China.
Zhang B; College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China. .
Ma F; College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China. .
Fan J; College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China. .
Qiu Z; College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China. .
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Źródło :
Food & function [Food Funct] 2022 Mar 21; Vol. 13 (6), pp. 3329-3342. Date of Electronic Publication: 2022 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Urodela*
Collagen/*chemistry
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*pharmacology
Peptide Fragments/*pharmacology
Skin/*chemistry
Animals ; Glucose/metabolism ; Glycogen/metabolism ; Glycoside Hydrolase Inhibitors ; Hep G2 Cells ; Humans ; Hypoglycemic Agents/metabolism ; Insulin Resistance ; Kinetics ; Malondialdehyde/metabolism ; Molecular Docking Simulation ; Network Pharmacology ; Oxidative Stress ; Peptide Fragments/metabolism ; Protein Hydrolysates ; Superoxide Dismutase/metabolism ; alpha-Glucosidases/metabolism
Czasopismo naukowe

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