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Tytuł :
Concise perspectives on some synthetic thiazolidine-2,4-dione derivatives and their specific pharmacodynamic aspects.
Autorzy :
Vulichi SR; Sri Venkateswara University College of Pharmaceutical Sciences, S V University, Tirupati, Andhra Pradesh, India; Department of Biological Sciences, BITS, Pilani, Hyderabad Campus, Telangana, India.
Kabra A; School of Pharmacy, Raffles University, Neemrana, Alwar, Rajasthan, India.
Kumar R; CDSCO, FDA Bhawan, New Delhi, India.
Suman K; Department of Biological Sciences, BITS, Pilani, Hyderabad Campus, Telangana, India. Electronic address: .
Rao CV; Department of Chemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.
Cruz-Martins N; Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319 Porto, Portugal; Institute for research and Innovation in Heath (i3S), University of Porto, Rua Alfredo Allen, 4200-135 Porto, Portugal; Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Portugal. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 15; Vol. 271, pp. 119182. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Hypoglycemic Agents/*chemistry
Hypoglycemic Agents/*metabolism
Thiazolidinediones/*chemistry
Thiazolidinediones/*metabolism
Animals ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Glucose/antagonists & inhibitors ; Glucose/metabolism ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin Resistance/physiology ; PPAR gamma/metabolism ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Thiazolidinediones/therapeutic use
Czasopismo naukowe
Tytuł :
In vitro and in vivo antidiabetic activity of Tamarix stricta Boiss.: Role of autophagy.
Autorzy :
Bahramsoltani R; Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: .
Farzaei MH; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: .
Sajadimajd S; Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran. Electronic address: .
Iranpanah A; Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: .
Khazaei M; Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: .
Pourjabar Z; Drug and Food Control Department, Faculty of Pharmacy, and Food and Drug Administration, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: .
Hajimahmoodi M; Drug and Food Control Department, Faculty of Pharmacy, and Food and Drug Administration, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: .
Rahimi R; Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran; PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Apr 06; Vol. 269, pp. 113692. Date of Electronic Publication: 2020 Dec 13.
Typ publikacji :
Journal Article
MeSH Terms :
Tamaricaceae*
Autophagy/*drug effects
Diabetes Mellitus, Experimental/*drug therapy
Hypoglycemic Agents/*therapeutic use
Plant Extracts/*therapeutic use
Animals ; Autophagy/physiology ; Diabetes Mellitus, Experimental/etiology ; Diabetes Mellitus, Experimental/metabolism ; Diet, High-Fat/adverse effects ; Dose-Response Relationship, Drug ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Mice ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Rats ; Streptozocin
Czasopismo naukowe
Tytuł :
Friedelin exhibits antidiabetic effect in diabetic rats via modulation of glucose metabolism in liver and muscle.
Autorzy :
Sunil C; Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai, 600034, India; Food Science and Technology Programme, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, Guangdong, 519087, China. Electronic address: .
Irudayaraj SS; Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai, 600034, India; St. Xavier's College, Maharo, Dumka, 814110, Jharkhand, India.
Duraipandiyan V; Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai, 600034, India. Electronic address: .
Alrashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Alharbi SA; Department of Botany and Microbiology, College of Science, King Saudi University, P.O Box 2455, Riyadh, 11451, Saudi Arabia.
Ignacimuthu S; Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai, 600034, India.
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 25; Vol. 268, pp. 113659. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Experimental/*drug therapy
Glucose/*antagonists & inhibitors
Hypoglycemic Agents/*therapeutic use
Liver/*drug effects
Muscle, Skeletal/*drug effects
Triterpenes/*therapeutic use
Animals ; Diabetes Mellitus, Experimental/metabolism ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Glucose/metabolism ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Liver/metabolism ; Male ; Muscle, Skeletal/metabolism ; Rats ; Rats, Wistar ; Triterpenes/isolation & purification ; Triterpenes/pharmacology
Czasopismo naukowe
Tytuł :
Antidiabetic effect of a flavonoid-rich extract from Sophora alopecuroides L. in HFD- and STZ- induced diabetic mice through PKC/GLUT4 pathway and regulating PPARα and PPARγ expression.
Autorzy :
Lv Y; School of Pharmaceutical Sciences, South-Central University for Nationalities, 182 Min-Zu Road, Wuhan, China; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhao P; School of Life Sciences, South-Central University for Nationalities, 182 Min-Zu Road, Wuhan, China.
Pang K; Hotian Uygur Pharmaceutical Co., Ltd, Hotian, 848200, China.
Ma Y; School of Pharmaceutical Sciences, South-Central University for Nationalities, 182 Min-Zu Road, Wuhan, China.
Huang H; School of Pharmaceutical Sciences, South-Central University for Nationalities, 182 Min-Zu Road, Wuhan, China.
Zhou T; School of Pharmaceutical Sciences, South-Central University for Nationalities, 182 Min-Zu Road, Wuhan, China.
Yang X; School of Pharmaceutical Sciences, South-Central University for Nationalities, 182 Min-Zu Road, Wuhan, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 25; Vol. 268, pp. 113654. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article
MeSH Terms :
Sophora*
Glucose Transporter Type 4/*biosynthesis
Hypoglycemic Agents/*therapeutic use
PPAR alpha/*biosynthesis
PPAR gamma/*biosynthesis
Protein Kinase C/*biosynthesis
Animals ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Diet, High-Fat/adverse effects ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Gene Expression ; Glucose Transporter Type 4/genetics ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; PPAR alpha/genetics ; PPAR gamma/genetics ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Protein Kinase C/genetics ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Streptozocin
Czasopismo naukowe
Tytuł :
Launaea acanthodes (Boiss) O. Kuntze mediates hepatic glucose metabolism and ameliorates impaired pancreatic function in streptozotocin-induced diabetic rats.
Autorzy :
Marvibaigi M; Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Hosseini SM; Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: .
Amini N; Department of Biology, Kavian Institute of Higher Education, Mashhad, Iran.
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 25; Vol. 268, pp. 113577. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Asteraceae*
Diabetes Mellitus, Experimental/*metabolism
Glucose/*metabolism
Hypoglycemic Agents/*therapeutic use
Liver/*metabolism
Pancreas/*metabolism
Animals ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/drug therapy ; Dose-Response Relationship, Drug ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Liver/drug effects ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Pancreas/drug effects ; Rats ; Rats, Wistar ; Streptozocin
Czasopismo naukowe
Tytuł :
Preoperative considerations of new long-acting glucagon-like peptide-1 receptor agonists in diabetes mellitus.
Autorzy :
Hulst AH; Department of Anaesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: .
Polderman JAW; Department of Anaesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Siegelaar SE; Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
van Raalte DH; Department of Internal Medicine, Amsterdam UMC, Amsterdam, the Netherlands.
DeVries JH; Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Profil Institute for Metabolic Research, Neuss, Germany.
Preckel B; Department of Anaesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Hermanides J; Department of Anaesthesiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
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Źródło :
British journal of anaesthesia [Br J Anaesth] 2021 Mar; Vol. 126 (3), pp. 567-571. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji :
Editorial
MeSH Terms :
Diabetes Mellitus/*drug therapy
Glucagon-Like Peptide-1 Receptor/*agonists
Hypoglycemic Agents/*therapeutic use
Preoperative Care/*methods
Blood Glucose/analysis ; Cardiovascular System/drug effects ; Delayed-Action Preparations ; Gastrointestinal Tract/drug effects ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/adverse effects
Opinia redakcyjna
Tytuł :
Tolerability, safety, pharmacokinetics and pharmacodynamics of SHR0534, a potent G protein-coupled receptor 40 (GPR40) agonist, at single- and multiple-ascending oral doses in healthy Chinese subjects.
Autorzy :
Zhao Y; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xie L; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Ou N; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wu J; Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, China.
Zhang H; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Zhou S; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Liu Y; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Chen J; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wang L; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wang L; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wang J; Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, China.
Shao F; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.; Pharmacy College, Nanjing Medical University, Nanjing, China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Mar; Vol. 51 (3), pp. 297-306. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Hypoglycemic Agents/*pharmacokinetics
Organic Chemicals/*pharmacokinetics
Receptors, G-Protein-Coupled/*agonists
Administration, Oral ; Adult ; Area Under Curve ; China ; Diabetes Mellitus, Type 2 ; Dose-Response Relationship, Drug ; Double-Blind Method ; Healthy Volunteers ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/pharmacology ; Metabolic Clearance Rate ; Organic Chemicals/administration & dosage ; Organic Chemicals/pharmacology
Czasopismo naukowe
Tytuł :
Tiliacora triandra (Colebr.) Diels Leaf Aqueous Extract Inhibits Hepatic Glucose Production in HepG2 Cells and Type 2 Diabetic Rats.
Autorzy :
Pasachan T; Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Duangjai A; Division of Physiology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.
Ontawong A; Division of Physiology, School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.
Amornlerdpison D; Centre of Excellence in Agricultural Innovation for Graduate Entrepreneur and Faculty of Fisheries Technology and Aquatic Resources, Maejo University, Chiang Mai 50290, Thailand.
Jinakote M; School of Human Kinetics and Health, Faculty of Health Science Technology, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok 10210, Thailand.
Phatsara M; Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Soodvilai S; Research Centre of Transport Protein for Medical Innovation, Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.; Excellent Centre for Drug Discovery, Mahidol University, Bangkok 10400, Thailand.
Srimaroeng C; Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 25; Vol. 26 (5). Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Diabetes Mellitus, Experimental/*drug therapy
Diabetes Mellitus, Type 2/*drug therapy
Glucose/*antagonists & inhibitors
Hypoglycemic Agents/*pharmacology
Menispermaceae/*chemistry
Plant Extracts/*pharmacology
Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/metabolism ; Drug Screening Assays, Antitumor ; Glucose/biosynthesis ; Hep G2 Cells ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/isolation & purification ; Injections, Intraperitoneal ; Male ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Leaves/chemistry ; Rats ; Rats, Wistar ; Reactive Oxygen Species/analysis ; Reactive Oxygen Species/metabolism ; Streptozocin/administration & dosage ; Tumor Cells, Cultured ; Water/chemistry
Czasopismo naukowe
Tytuł :
Preliminary Investigation of the Antioxidant, Anti-Diabetic, and Anti-Inflammatory Activity of Enteromorpha intestinalis Extracts.
Autorzy :
Pradhan B; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India.
Patra S; Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Rourkela 769008, India.
Behera C; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India.
Nayak R; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India.
Jit BP; Department of Biochemistry, All India Institute of Medical Science, Ansari Nagar, New Delhi 110023, India.
Ragusa A; Department of Biological and Environmental Sciences and Technologies, Campus Ecotekne, University of Salento, via Monteroni, 73100 Lecce, Italy.; CNR-Nanotec, Institute of Nanotechnology, via Monteroni, 73100 Lecce, Italy.
Jena M; Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, India.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 22; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Enzyme Inhibitors/*pharmacology
Hypoglycemic Agents/*pharmacology
Plant Extracts/*pharmacology
Ulva/*chemistry
Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/isolation & purification ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Biphenyl Compounds/antagonists & inhibitors ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Erythrocytes/drug effects ; Erythrocytes/metabolism ; Flavonoids/chemistry ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Humans ; Hydroxyl Radical/antagonists & inhibitors ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/isolation & purification ; Lipoxygenases/metabolism ; Male ; Peptide Hydrolases/metabolism ; Phenols/chemistry ; Phenols/isolation & purification ; Phenols/pharmacology ; Picrates/antagonists & inhibitors ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Superoxides/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.
Autorzy :
Hoguet V; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.
Lasalle M; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.
Maingot M; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.
Dequirez G; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.
Boulahjar R; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.
Leroux F; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, EGID, F-59000 Lille, France.
Piveteau C; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.
Herledan A; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.
Biela A; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.
Dumont J; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.
Chávez-Talavera O; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France.
Belloy L; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France.
Duplan I; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France.
Hennuyer N; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France.
Butruille L; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France.
Lestavel S; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France.
Sevin E; Univ. Artois, UR 2465, Blood-brain barrier laboratory (LBHE), F-62300 Lens, France.
Culot M; Univ. Artois, UR 2465, Blood-brain barrier laboratory (LBHE), F-62300 Lens, France.
Gosselet F; Univ. Artois, UR 2465, Blood-brain barrier laboratory (LBHE), F-62300 Lens, France.
Staels B; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France.
Deprez B; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, EGID, F-59000 Lille, France.
Tailleux A; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France.
Charton J; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, EGID, F-59000 Lille, France.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Feb 11; Vol. 64 (3), pp. 1593-1610. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypoglycemic Agents/*chemical synthesis
Hypoglycemic Agents/*pharmacology
Receptors, G-Protein-Coupled/*agonists
Animals ; Blood-Brain Barrier/metabolism ; Caco-2 Cells ; HEK293 Cells ; Humans ; Hypoglycemic Agents/pharmacokinetics ; Male ; Mice ; Mice, Inbred C57BL ; Microsomes, Liver/metabolism ; Polyethylene Glycols/chemistry ; Receptors, G-Protein-Coupled/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Glargine insulin loaded lipid nanoparticles: Oral delivery of liquid and solid oral dosage forms.
Autorzy :
Muntoni E; University of Turin, Department of Drug Science and Technology, Via Pietro Giuria 9, Turin, Italy.
Anfossi L; University of Turin, Department of Chemistry, Via Pietro Giuria 7, Turin, Italy.
Milla P; University of Turin, Department of Drug Science and Technology, Via Pietro Giuria 9, Turin, Italy.
Marini E; University of Turin, Department of Drug Science and Technology, Via Pietro Giuria 9, Turin, Italy.
Ferraris C; University of Turin, Department of Drug Science and Technology, Via Pietro Giuria 9, Turin, Italy.
Capucchio MT; University of Turin, Department of Veterinary Sciences, Largo Paolo Braccini 2, Grugliasco, Italy.
Colombino E; University of Turin, Department of Veterinary Sciences, Largo Paolo Braccini 2, Grugliasco, Italy.
Segale L; University of Eastern Piedmont, Department of Pharmaceutical Sciences, Largo Donegani 2/3, Novara, Italy.
Porta M; University of Turin, Department of Medical Sciences, Corso Dogliotti 14, Turin, Italy.
Battaglia L; University of Turin, Department of Drug Science and Technology, Via Pietro Giuria 9, Turin, Italy. Electronic address: .
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Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Feb 08; Vol. 31 (2), pp. 691-698. Date of Electronic Publication: 2020 Oct 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Carriers*
Nanoparticles*
Blood Glucose/*drug effects
Hypoglycemic Agents/*administration & dosage
Insulin Glargine/*administration & dosage
Lipids/*chemistry
Administration, Oral ; Animals ; Biomarkers/blood ; Blood Glucose/metabolism ; Capsules ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/drug therapy ; Drug Compounding ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/pharmacokinetics ; Insulin Glargine/chemistry ; Insulin Glargine/pharmacokinetics ; Male ; Pharmaceutical Solutions ; Rats, Wistar ; Streptozocin ; Tablets
Czasopismo naukowe
Tytuł :
Efficacy and safety of Shenqi Jiangtang Granules plus oral hypoglycemic agent in patients with type 2 diabetes mellitus: A protocol for systematic review and meta-analysis of 15 RCTs.
Autorzy :
Li T; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Dongcheng District.; Beijing University of Chinese medicine, Chaoyang District.; Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District.
Li H; Beijing University of Chinese medicine, Chaoyang District.; Department of Cardiology, Guang'an men hospital, China Academy of Chinese Medical Sciences, Xicheng District, Beijing.
Wu Y; Beijing University of Chinese medicine, Chaoyang District.; Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District.
Wu Q; Department of Cardiology, Guang'an men hospital, China Academy of Chinese Medical Sciences, Xicheng District, Beijing.
Zhao G; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Dongcheng District.; Beijing University of Chinese medicine, Chaoyang District.
Cai Z; Department of Gastroenterology, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Pu F; Beijing University of Chinese medicine, Chaoyang District.
Li B; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Dongcheng District.
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Źródło :
Medicine [Medicine (Baltimore)] 2021 Feb 05; Vol. 100 (5), pp. e23578.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Drugs, Chinese Herbal/*therapeutic use
Hypoglycemic Agents/*therapeutic use
Blood Glucose ; Drug Therapy, Combination ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/adverse effects ; Glycated Hemoglobin A ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/adverse effects ; Postprandial Period ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
Assessment of treatment satisfaction and adherence amongst diabetic patients in governmental primary care clinic of Ramallah, West-Bank.
Autorzy :
Khdour M; Department of Pharmacy, Al Quds University , Jerusalem, Israel.
Awadallah HB; Department of Pharmacy, Al Quds University , Jerusalem, Israel.
Al-Hamed DH; Department of Pharmacy, Ramallah and Al-bireh health directorate , West Bank, Palestine.
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Źródło :
Hospital practice (1995) [Hosp Pract (1995)] 2021 Feb; Vol. 49 (1), pp. 27-33. Date of Electronic Publication: 2020 Sep 20.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*therapeutic use
Medication Adherence/*statistics & numerical data
Patient Satisfaction/*statistics & numerical data
Adult ; Aged ; Blood Glucose ; Cross-Sectional Studies ; Female ; Glycated Hemoglobin A ; Health Behavior ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/adverse effects ; Male ; Medication Adherence/psychology ; Middle Aged ; Middle East ; Socioeconomic Factors
Czasopismo naukowe
Tytuł :
Impact of blinded retrospective continuous glucose monitoring on clinical decision making and glycemic control in persons with type 2 diabetes on insulin therapy.
Autorzy :
Ribeiro RT; APDP - Diabetes Portugal, Lisbon, Portugal; iBiMED, Dep of Medical Sciences, University of Aveiro, Portugal; CEDOC, NOVA University of Lisbon, Portugal. Electronic address: .
Andrade R; APDP - Diabetes Portugal, Lisbon, Portugal.
Nascimento do Ó D; APDP - Diabetes Portugal, Lisbon, Portugal.
Lopes AF; APDP - Diabetes Portugal, Lisbon, Portugal.
Raposo JF; APDP - Diabetes Portugal, Lisbon, Portugal; CEDOC, NOVA University of Lisbon, Portugal; Dep of Public Health, NOVA Medical School, NOVA University of Lisbon, Portugal.
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Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Apr 09; Vol. 31 (4), pp. 1267-1275. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Glucose Self-Monitoring*
Clinical Decision-Making*
Glycemic Control*/adverse effects
Blood Glucose/*drug effects
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*therapeutic use
Insulin/*therapeutic use
Adolescent ; Adult ; Aged ; Biomarkers/blood ; Blood Glucose/metabolism ; Decision Making, Shared ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Female ; Glycated Hemoglobin A/metabolism ; Humans ; Hypoglycemia/blood ; Hypoglycemia/etiology ; Hypoglycemia/prevention & control ; Hypoglycemic Agents/adverse effects ; Insulin/adverse effects ; Male ; Middle Aged ; Patient Satisfaction ; Predictive Value of Tests ; Prospective Studies ; Retrospective Studies ; Risk Reduction Behavior ; Time Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Efficacy and safety of glucose-lowering agents in patients with type 2 diabetes: A network meta-analysis of randomized, active comparator-controlled trials.
Autorzy :
Mannucci E; Diabetology, Careggi Hospital, Florence, Italy; University of Florence, Italy.
Naletto L; University of Florence, Italy.
Vaccaro G; University of Florence, Italy.
Silverii A; Diabetology, Careggi Hospital, Florence, Italy.
Dicembrini I; Diabetology, Careggi Hospital, Florence, Italy; University of Florence, Italy.
Pintaudi B; SSD Diabetes Unit, Niguarda Ca' Granda Hospital, Milan, Italy.
Monami M; Diabetology, Careggi Hospital, Florence, Italy. Electronic address: .
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Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Apr 09; Vol. 31 (4), pp. 1027-1034. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Blood Glucose/*drug effects
Diabetes Mellitus, Type 2/*drug therapy
Hypoglycemic Agents/*therapeutic use
Aged ; Biomarkers/blood ; Blood Glucose/metabolism ; Body Weight/drug effects ; Clinical Decision-Making ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Female ; Gastrointestinal Diseases/chemically induced ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemic Agents/adverse effects ; Male ; Middle Aged ; Network Meta-Analysis ; Quality of Life ; Randomized Controlled Trials as Topic ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Insulin storage without refrigeration.
Autorzy :
Makoni M
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Źródło :
The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2021 Apr; Vol. 9 (4), pp. 202.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Refugee Camps*/standards
Diabetes Mellitus/*drug therapy
Drug Storage/*methods
Hypoglycemic Agents/*therapeutic use
Insulin/*therapeutic use
Refrigeration/*methods
Diabetes Mellitus/epidemiology ; Drug Storage/standards ; Humans ; Hypoglycemic Agents/standards ; Insulin/standards ; Refrigeration/standards
Czasopismo naukowe
Tytuł :
Failing to address access to insulin in its centenary year would be a catastrophic moral failure.
Autorzy :
Beran D; Division of Tropical and Humanitarian Medicine, University of Geneva, Geneva 1211, Switzerland; Geneva University Hospitals, Geneva, Switzerland. Electronic address: .
Colagiuri S; Boden Collaboration, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, SNW, Australia.
Ernoult N; MSF Access Campaign, Médecins Sans Frontières, Paris, France.
Ewen M; Health Action International, Amsterdam, Netherlands.
Fleury C; Conservatoire National des Arts et Métiers, Paris, France.
Lepeska M; Health Action International, Amsterdam, Netherlands.
Londeix P; NGO Santé Diabète, Grenoble, France; Observatoire de la Transparence dans les Politiques du Médicament, Paris, France.
Pfiester E; T1International, Cheltenham, UK.
Yudkin JS; Institute of Cardiovascular Science, Division of Medicine, University College London, London, UK.
Besançon S; NGO Santé Diabète, Bamako, Mali.
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Źródło :
The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2021 Apr; Vol. 9 (4), pp. 194-196. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Health Services Accessibility*/trends
Morals*
World Health Organization*
Diabetes Mellitus/*drug therapy
Hypoglycemic Agents/*supply & distribution
Insulin/*supply & distribution
Diabetes Mellitus/epidemiology ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use
Czasopismo naukowe
Tytuł :
Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model.
Autorzy :
Fang X; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China. Electronic address: .
Du Z; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Duan C; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Zhan S; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Wang T; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Zhu M; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Shi J; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Meng J; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Zhang X; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Yang M; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
Zuo Y; Innovation Center, Shanghai Benemae Pharmaceutical Corporation, 916 Ziping Road, Zhoupu, PuDong, Shanghai, China.
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Źródło :
Life sciences [Life Sci] 2021 Apr 01; Vol. 270, pp. 118966. Date of Electronic Publication: 2021 Jan 19.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus/*metabolism
Glucagon-Like Peptide 1/*analogs & derivatives
Hypoglycemic Agents/*pharmacology
Non-alcoholic Fatty Liver Disease/*drug therapy
Obesity/*metabolism
Peptide Fragments/*pharmacology
Animals ; Antioxidants/pharmacology ; Diabetes Complications/drug therapy ; Diabetes Mellitus/drug therapy ; Glucagon-Like Peptide 1/metabolism ; Glucagon-Like Peptide 1/pharmacology ; Hypoglycemic Agents/metabolism ; Insulin/metabolism ; Insulin Resistance ; Leptin/metabolism ; Liraglutide/pharmacology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Non-alcoholic Fatty Liver Disease/metabolism ; Obesity/complications ; Oxidation-Reduction ; PPAR alpha/metabolism ; Peptide Fragments/chemistry ; Weight Loss/drug effects
Czasopismo naukowe
Tytuł :
Characterization and hypoglycemic effects of sulfated polysaccharides derived from brown seaweed Undaria pinnatifida.
Autorzy :
Zhong QW; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Zhou TS; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Qiu WH; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Wang YK; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Xu QL; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Ke SZ; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Wang SJ; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China; Center for Human Nutrition, David Geffen School of Medicine, University of California, Rehabilitation Building 32-21, 1000 Veteran Avenue, Los Angeles, CA 90024, USA.
Jin WH; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Chen JW; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Zhang HW; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
Wei B; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address: .
Wang H; College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Mar 30; Vol. 341 (Pt 1), pp. 128148. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoglycemic Agents/*pharmacology
Polysaccharides/*pharmacology
Seaweed/*chemistry
Undaria/*chemistry
Animals ; Chemical Fractionation ; Diet, High-Fat/adverse effects ; Glucose/metabolism ; Glucose/pharmacokinetics ; Hep G2 Cells ; Humans ; Hyperglycemia/drug therapy ; Hyperglycemia/etiology ; Hypoglycemic Agents/chemistry ; Insulin/pharmacology ; Insulin Resistance ; Male ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Microwaves ; Polysaccharides/chemistry ; Polysaccharides/isolation & purification ; Postprandial Period ; Sulfates/chemistry
Czasopismo naukowe

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