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Tytuł:
The hair cell analysis toolbox is a precise and fully automated pipeline for whole cochlea hair cell quantification.
Autorzy:
Buswinka CJ; Mass Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.; Speech and Hearing Bioscience and Technology Program, Harvard University, Cambridge, Massachusetts, United States of America.
Osgood RT; Mass Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Simikyan RG; Mass Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Rosenberg DB; Mass Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Indzhykulian AA; Mass Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.; Speech and Hearing Bioscience and Technology Program, Harvard University, Cambridge, Massachusetts, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2023 Mar 22; Vol. 21 (3), pp. e3002041. Date of Electronic Publication: 2023 Mar 22 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cochlea*
Hair Cells, Vestibular*
Hair Cells, Auditory, Inner/metabolism ; Hair Cells, Auditory, Outer/metabolism ; Hearing
Czasopismo naukowe
Tytuł:
Cochlear Ribbon Synapses in Aged Gerbils.
Autorzy:
Bovee S; Department of Neuroscience, School of Medicine and Health Science, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.
Klump GM; Department of Neuroscience, School of Medicine and Health Science, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.; Cluster of Excellence 'Hearing4all', Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.; Research Centre Neurosensory Science, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.
Pyott SJ; Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Sielaff C; Department of Neuroscience, School of Medicine and Health Science, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625 Hannover, Germany.
Köppl C; Department of Neuroscience, School of Medicine and Health Science, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.; Cluster of Excellence 'Hearing4all', Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.; Research Centre Neurosensory Science, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 27; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Cochlea*/metabolism
Synapses*/metabolism
Animals ; Gerbillinae ; Cochlear Nerve/metabolism ; Hair Cells, Auditory, Inner/metabolism
Czasopismo naukowe
Tytuł:
Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1.
Autorzy:
Veithen M; Laboratory of Developmental Neurobiology, GIGA-Neurosciences, University of Liege, 4000 Liege, Belgium.
Huyghe A; Laboratory of Developmental Neurobiology, GIGA-Neurosciences, University of Liege, 4000 Liege, Belgium.
Van Den Ackerveken P; Laboratory of Developmental Neurobiology, GIGA-Neurosciences, University of Liege, 4000 Liege, Belgium.
Fukada SI; Laboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.
Kokubo H; Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minamiku, Hiroshima 734-8551, Japan.
Breuskin I; Laboratory of Developmental Neurobiology, GIGA-Neurosciences, University of Liege, 4000 Liege, Belgium.
Nguyen L; Laboratory of Molecular Regulation of Neurogenesis, GIGA-Neurosciences, University of Liege, 4000 Liege, Belgium.
Delacroix L; Laboratory of Developmental Neurobiology, GIGA-Neurosciences, University of Liege, 4000 Liege, Belgium.
Malgrange B; Laboratory of Developmental Neurobiology, GIGA-Neurosciences, University of Liege, 4000 Liege, Belgium.
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Źródło:
Cells [Cells] 2023 Aug 25; Vol. 12 (17). Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hair Cells, Auditory*
Cochlea*
Epithelium ; Cell Differentiation ; Electroporation
Czasopismo naukowe
Tytuł:
Ultrastructure of noise-induced cochlear synaptopathy.
Autorzy:
Moverman DJ; Eaton-Peabody Laboratories, Massachusetts Eye and Ear, 243 Charles St., Boston, MA, 02114-3096, USA.
Liberman LD; Eaton-Peabody Laboratories, Massachusetts Eye and Ear, 243 Charles St., Boston, MA, 02114-3096, USA.
Kraemer S; Center for Nanoscale Systems, Harvard College, Cambridge, MA, 02138, USA.
Corfas G; Department of Otolaryngology-Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA.
Liberman MC; Eaton-Peabody Laboratories, Massachusetts Eye and Ear, 243 Charles St., Boston, MA, 02114-3096, USA. Charles_.; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, 02115, USA. Charles_.
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 09; Vol. 13 (1), pp. 19456. Date of Electronic Publication: 2023 Nov 09.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
Cochlea*/physiology
Hearing Loss, Noise-Induced*
Mice ; Animals ; Noise/adverse effects ; Hair Cells, Auditory ; Hair Cells, Auditory, Inner/physiology ; Synapses/ultrastructure ; Cochlear Nerve ; Auditory Threshold/physiology
Czasopismo naukowe
Tytuł:
Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea and Is Necessary for Hearing Function in Mice.
Autorzy:
Saegusa C; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa 252-0374, Japan.; Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.
Kakegawa W; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Miura E; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Aimi T; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Mogi S; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Kanagawa 252-0374, Japan.
Harada T; Department of Otolaryngology, International University of Health and Welfare, Shizuoka 413-0012, Japan.
Yamashita T; Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University, Kanagawa 252-0374, Japan.
Yuzaki M; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Fujioka M; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa 252-0374, Japan.; Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.; Clinical and Translational Research Center, Keio University Hospital, Tokyo 162-8582, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 04; Vol. 24 (23). Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:
Journal Article
MeSH Terms:
Cochlea*/metabolism
Hearing*
Nerve Tissue Proteins*/genetics
Membrane Proteins*/genetics
Animals ; Mice ; Brain ; Hair Cells, Auditory, Outer ; Mice, Knockout
Czasopismo naukowe
Tytuł:
Regeneration of Hair Cells from Endogenous Otic Progenitors in the Adult Mammalian Cochlea: Understanding Its Origins and Future Directions.
Autorzy:
Smith-Cortinez N; Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.; UMC Utrecht Brain Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Tan AK; Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.; UMC Utrecht Brain Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Stokroos RJ; Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.; UMC Utrecht Brain Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Versnel H; Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.; UMC Utrecht Brain Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Straatman LV; Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.; UMC Utrecht Brain Center, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 25; Vol. 24 (9). Date of Electronic Publication: 2023 Apr 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hair Cells, Auditory*/metabolism
Cochlea*/metabolism
Infant, Newborn ; Adult ; Humans ; Signal Transduction ; Spiral Ganglion ; Neurogenesis
Czasopismo naukowe
Tytuł:
β-Catenin transcriptional activity is required for establishment of inner pillar cell identity during cochlear development.
Autorzy:
Ebeid M; Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.; Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Kishimoto I; Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, United States of America.
Roy P; Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Zaidi MAA; Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
Cheng AG; Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, United States of America.
Huh SH; Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.; Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.; Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
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Źródło:
PLoS genetics [PLoS Genet] 2023 Aug 28; Vol. 19 (8), pp. e1010925. Date of Electronic Publication: 2023 Aug 28 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
beta Catenin*/genetics
Cochlea*
Animals ; Hair Cells, Auditory ; Cell Adhesion/genetics ; Cell Differentiation/genetics ; Mammals
Czasopismo naukowe
Tytuł:
Loss of Pex1 in Inner Ear Hair Cells Contributes to Cochlear Synaptopathy and Hearing Loss.
Autorzy:
Mauriac SA; Department of Otolaryngology, Boston Children's Hospital, Boston, MA 02115, USA.; Kirby Neurobiology Center, Harvard Medical School, Boston, MA 02115, USA.
Peineau T; Department of Otolaryngology, Boston Children's Hospital, Boston, MA 02115, USA.; Kirby Neurobiology Center, Harvard Medical School, Boston, MA 02115, USA.
Zuberi A; Rare Disease Translational Center, The Jackson Laboratory, Bar Harbor, ME 04609, USA.; Technology Evaluation and Development Research Laboratory, The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Lutz C; Rare Disease Translational Center, The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Géléoc GSG; Department of Otolaryngology, Boston Children's Hospital, Boston, MA 02115, USA.; Kirby Neurobiology Center, Harvard Medical School, Boston, MA 02115, USA.
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Źródło:
Cells [Cells] 2022 Dec 09; Vol. 11 (24). Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cochlea*/innervation
Cochlea*/metabolism
Hair Cells, Auditory, Inner*/metabolism
Hearing Loss*/genetics
Hearing Loss*/metabolism
Synapses*/genetics
Synapses*/metabolism
Animals ; Mice ; ATPases Associated with Diverse Cellular Activities/genetics ; ATPases Associated with Diverse Cellular Activities/metabolism ; Deafness/genetics ; Deafness/metabolism ; Hearing/physiology ; Mice, Knockout
Czasopismo naukowe
Tytuł:
Preservation of developmental spontaneous activity enables early auditory system maturation in deaf mice.
Autorzy:
Kersbergen CJ; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, United States of America.
Babola TA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, United States of America.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America.
Kanold PO; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America.
Bergles DE; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland, United States of America.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America.; Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, United States of America.; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, Maryland, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2023 Jun 27; Vol. 21 (6), pp. e3002160. Date of Electronic Publication: 2023 Jun 27 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cochlea*/physiology
Deafness*/genetics
Mice ; Animals ; Connexin 26 ; Hair Cells, Auditory/physiology ; Hair Cells, Auditory, Inner/physiology
Czasopismo naukowe
Tytuł:
Cross-species experiments reveal widespread cochlear neural damage in normal hearing.
Autorzy:
Bharadwaj HM; Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, USA. .; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. .
Hustedt-Mai AR; Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, USA.
Ginsberg HM; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Dougherty KM; Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, USA.
Muthaiah VPK; Department of Rehabilitation Sciences, University at Buffalo, Buffalo, NY, USA.
Hagedorn A; Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, USA.
Simpson JM; Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, USA.
Heinz MG; Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN, USA.; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
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Źródło:
Communications biology [Commun Biol] 2022 Jul 22; Vol. 5 (1), pp. 733. Date of Electronic Publication: 2022 Jul 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cochlea*
Hair Cells, Auditory*/physiology
Acoustic Stimulation ; Animals ; Chinchilla ; Hearing ; Humans ; Middle Aged
Czasopismo naukowe
Tytuł:
Cochlear motion across the reticular lamina implies that it is not a stiff plate.
Autorzy:
Cho NH; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, 02114, USA.; Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA, 02114, USA.
Puria S; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA, 02114, USA. Sunil_.; Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA, 02114, USA. Sunil_.; Speech and Hearing Bioscience and Technology Program, Harvard University, Cambridge, MA, 02138, USA. Sunil_.
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Źródło:
Scientific reports [Sci Rep] 2022 Nov 04; Vol. 12 (1), pp. 18715. Date of Electronic Publication: 2022 Nov 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Organ of Corti*
Cochlea*
Animals ; Basilar Membrane ; Hair Cells, Auditory, Outer ; Motion ; Gerbillinae
Czasopismo naukowe
Tytuł:
Dibenzazepine promotes cochlear supporting cell proliferation and hair cell regeneration in neonatal mice.
Autorzy:
Wu J; Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Biomedical Sciences, Fudan University School of Basic Medical Sciences, Shanghai, China.
Dong X; Molecular Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Li W; Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Biomedical Sciences, Fudan University School of Basic Medical Sciences, Shanghai, China.
Zhao L; Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Biomedical Sciences, Fudan University School of Basic Medical Sciences, Shanghai, China.
Zhou L; Shanghai High School, Shanghai, China.
Sun S; Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Biomedical Sciences, Fudan University School of Basic Medical Sciences, Shanghai, China.
Li H; Otorhinolaryngology Department of Eye & ENT Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Hearing Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Biomedical Sciences, Fudan University School of Basic Medical Sciences, Shanghai, China.; The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.
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Źródło:
Cell proliferation [Cell Prolif] 2020 Sep; Vol. 53 (9), pp. e12872. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Proliferation/*drug effects
Cochlea/*drug effects
Dibenzazepines/*pharmacology
Hair Cells, Auditory/*drug effects
Animals ; Animals, Newborn ; Cochlea/cytology ; Cochlea/physiology ; Enzyme Inhibitors/pharmacology ; Hair Cells, Auditory/cytology ; Hair Cells, Auditory/physiology ; Mice ; Mice, Inbred C57BL ; Organ Culture Techniques ; Receptors, Notch/metabolism ; Regeneration/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea.
Autorzy:
Lee S; Kresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, The University of Michigan, Ann Arbor, MI, USA.; Department of Otolaryngology - Head and Neck Surgery, Chonnam National University Hospital, Gwangju, South Korea.
Song JJ; Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea.
Beyer LA; Kresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, The University of Michigan, Ann Arbor, MI, USA.
Swiderski DL; Kresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, The University of Michigan, Ann Arbor, MI, USA.
Prieskorn DM; Kresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, The University of Michigan, Ann Arbor, MI, USA.
Acar M; Department of Medical Biology, School of Medicine, Bahcesehir University, Istanbul, Turkey.
Jen HI; Department of Neuroscience, Baylor College of Medicine, Houston, USA.
Groves AK; Department of Neuroscience, Baylor College of Medicine, Houston, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, USA.
Raphael Y; Kresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, The University of Michigan, Ann Arbor, MI, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Dec 08; Vol. 10 (1), pp. 21397. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Regeneration*
Basic Helix-Loop-Helix Transcription Factors/*genetics
Cochlea/*transplantation
DNA-Binding Proteins/*genetics
Hair Cells, Auditory/*cytology
Transcription Factors/*genetics
Animals ; Animals, Newborn ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cells, Cultured ; DNA-Binding Proteins/metabolism ; Dependovirus/genetics ; Female ; Gene Transfer Techniques ; Hair Cells, Auditory/metabolism ; Male ; Mice ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Molecular Pathways Modulating Sensory Hair Cell Regeneration in Adult Mammalian Cochleae: Progress and Perspectives.
Autorzy:
Rai V; Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.
Tu S; Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.
Frank JR; Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.
Zuo J; Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Dec 22; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 22.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cochlea/*metabolism
Hair Cells, Auditory/*metabolism
Hearing Loss/*metabolism
Mammals/*metabolism
Regeneration/*physiology
Animals ; Hearing/physiology ; Humans ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Some Ototoxic Drugs Destroy Cochlear Support Cells Before Damaging Sensory Hair Cells.
Autorzy:
Ding D; Center for Hearing and Deafness, University at Buffalo, 137 Cary Hall, Buffalo, NY, 14214, USA.; Department of Otolaryngology Head and Neck Surgery, The Third People's Hospital of Chengdu, Chengdu, China.
Zhang J; Department of Otolaryngology Head and Neck Surgery, The Third People's Hospital of Chengdu, Chengdu, China.
Jiang H; Center for Hearing and Deafness, University at Buffalo, 137 Cary Hall, Buffalo, NY, 14214, USA.
Xuan W; Department of Otolaryngology, Ren-Ai Hospital, Guangxi University of Chinese Medicine, Nanning, China.
Qi W; Department of Otolaryngology Head and Neck Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Salvi R; Center for Hearing and Deafness, University at Buffalo, 137 Cary Hall, Buffalo, NY, 14214, USA. .; Department of Audiology and Speech-Language Pathology, Asia University, Taiwan, China. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2020 Mar; Vol. 37 (3), pp. 743-752. Date of Electronic Publication: 2020 Jan 29.
Typ publikacji:
Journal Article
MeSH Terms:
Cochlea/*drug effects
Cochlea/*pathology
Hair Cells, Auditory/*drug effects
Hair Cells, Auditory/*pathology
Ototoxicity/*pathology
Animals ; Apoptosis/drug effects ; Cadmium/toxicity ; Caspases/metabolism ; Cisplatin/toxicity ; Cochlea/metabolism ; Extracellular Matrix/drug effects ; Extracellular Matrix/pathology ; Gentamicins/toxicity ; Hair Cells, Auditory/metabolism ; Mefloquine/toxicity ; Ototoxicity/metabolism ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł:
Wnt Modulation Enhances Otic Differentiation by Facilitating the Enucleation Process but Develops Unnecessary Cardiac Structures.
Autorzy:
Carpena NT; Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
Chang SY; Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.; Medical Laser Research Center, Dankook University, Cheonan 31116, Korea.; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
Choi JE; Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.; Medical Laser Research Center, Dankook University, Cheonan 31116, Korea.; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
Jung JY; Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
Lee MY; Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.; Medical Laser Research Center, Dankook University, Cheonan 31116, Korea.; Beckman Laser Institute Korea, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 24; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 24.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation/*physiology
Cochlea/*metabolism
Cochlea/*physiology
Organoids/*metabolism
Organoids/*physiology
Wnt Signaling Pathway/*physiology
Animals ; Cells, Cultured ; Ear, Inner/metabolism ; Hair Cells, Auditory/metabolism ; Hair Cells, Auditory/physiology ; Mice ; Mouse Embryonic Stem Cells/metabolism ; Mouse Embryonic Stem Cells/physiology ; Pluripotent Stem Cells/metabolism
Czasopismo naukowe
Tytuł:
Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity.
Autorzy:
Gonçalves AC; UCL Ear Institute, University College London, 332 Gray's Inn Road, WC1X 8EE, London, UK.
Towers ER; UCL Ear Institute, University College London, 332 Gray's Inn Road, WC1X 8EE, London, UK.
Haq N; UCL Ear Institute, University College London, 332 Gray's Inn Road, WC1X 8EE, London, UK.
Porco JA Jr; Department of Chemistry, Center for Molecular Discovery, Boston University, Boston, MA, 02215, USA.
Pelletier J; Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Dawson SJ; UCL Ear Institute, University College London, 332 Gray's Inn Road, WC1X 8EE, London, UK. .
Gale JE; UCL Ear Institute, University College London, 332 Gray's Inn Road, WC1X 8EE, London, UK. .
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Źródło:
Scientific reports [Sci Rep] 2019 Aug 29; Vol. 9 (1), pp. 12501. Date of Electronic Publication: 2019 Aug 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aminoglycosides/*toxicity
Cochlea/*drug effects
Hair Cells, Auditory/*drug effects
Hearing Loss/*physiopathology
Neurodegenerative Diseases/*physiopathology
Animals ; Cochlea/metabolism ; Cochlea/physiopathology ; Eukaryotic Initiation Factor-4F/genetics ; Eukaryotic Initiation Factor-4F/metabolism ; Hair Cells, Auditory/physiology ; Hearing Loss/etiology ; Hearing Loss/genetics ; Hearing Loss/metabolism ; Humans ; Mice ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Ototoxicity ; Stress, Physiological/drug effects
Czasopismo naukowe
Tytuł:
The origin of mechanical harmonic distortion within the organ of Corti in living gerbil cochleae.
Autorzy:
He W; Oregon Hearing Research Center, Department of Otolaryngology, Oregon Health & Science University, Portland, OR, USA.
Ren T; Oregon Hearing Research Center, Department of Otolaryngology, Oregon Health & Science University, Portland, OR, USA. .
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Źródło:
Communications biology [Commun Biol] 2021 Aug 25; Vol. 4 (1), pp. 1008. Date of Electronic Publication: 2021 Aug 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cochlea/*physiology
Gerbillinae/*physiology
Organ of Corti/*physiology
Animals ; Biomechanical Phenomena ; Hair Cells, Auditory, Outer/physiology ; Interferometry ; Vibration
Czasopismo naukowe
Tytuł:
Static length changes of cochlear outer hair cells can tune low-frequency hearing.
Autorzy:
Ciganović N; Department of Bioengineering, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.
Warren RL; Department of Clinical and Experimental Medicine, Linköping University, SE-581 85 Linköping, Sweden.
Keçeli B; Department of Clinical and Experimental Medicine, Linköping University, SE-581 85 Linköping, Sweden.
Jacob S; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Fridberger A; Department of Clinical and Experimental Medicine, Linköping University, SE-581 85 Linköping, Sweden.
Reichenbach T; Department of Bioengineering, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.; Kavli Institute for Theoretical Physics, University of California at Santa Barbara, Santa Barbara, CA 93106, United States of America.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2018 Jan 19; Vol. 14 (1), pp. e1005936. Date of Electronic Publication: 2018 Jan 19 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cochlea/*physiology
Hair Cells, Auditory, Outer/*physiology
Hearing/*physiology
Organ of Corti/*physiology
Animals ; Biomechanical Phenomena ; Computational Biology ; Elasticity ; Female ; Guinea Pigs ; Hair Cells, Auditory, Inner/physiology ; Interferometry ; Male ; Microscopy, Confocal ; Models, Biological ; Motion ; Music ; Neurons/physiology ; Signal Processing, Computer-Assisted
Czasopismo naukowe
Tytuł:
Change in gene expression levels of GABA, glutamate and neurosteroid pathways due to acoustic trauma in the cochlea.
Autorzy:
Cerrah Gunes M; Department of Medical Genetics, School of Medicine, Erciyes University, Kayseri, Turkey.
Gunes MS; Department of Otolaryngology, Izmit Seka State Hospital, Kocaeli, Turkey.
Vural A; Department of Otolaryngology, School of Medicine, Erciyes University, Kayseri, Turkey.
Aybuga F; Center of Genome and Stem Cell, Kayseri, Turkey.
Bayram A; Etlik Zübeyde Hanım Women's Diseases Education and Research Hospital, Health Sciences University, T.R. Ministry of Health, Ankara, Turkey.
Bayram KK; Department of Medical Genetics, School of Medicine, Yıldirim Beyazit University, Ankara, Turkey.
Sahin MI; Department of Otolaryngology, School of Medicine, Erciyes University, Kayseri, Turkey.
Dogan ME; Department of Medical Genetics, School of Medicine, Erciyes University, Kayseri, Turkey.
Ozdemir SY; Department of Medical Genetics, School of Medicine, Uskudar University, Istanbul, Turkey.
Ozkul Y; Department of Medical Genetics, School of Medicine, Erciyes University, Kayseri, Turkey.; Center of Genome and Stem Cell, Kayseri, Turkey.
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Źródło:
Journal of neurogenetics [J Neurogenet] 2021 Mar; Vol. 35 (1), pp. 45-57. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji:
Journal Article
MeSH Terms:
Cochlea/*metabolism
Glutamic Acid/*genetics
Hearing Loss, Noise-Induced/*genetics
Neurosteroids/*metabolism
gamma-Aminobutyric Acid/*genetics
Animals ; Glutamic Acid/metabolism ; Hair Cells, Auditory, Inner/metabolism ; Hair Cells, Auditory, Outer/metabolism ; Hearing Loss, Noise-Induced/metabolism ; Mice ; Mice, Inbred BALB C ; gamma-Aminobutyric Acid/metabolism
Czasopismo naukowe

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