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    Wyświetlanie 1-16 z 16
    Tytuł:
    Machine Learning Reduced Gene/Non-Coding RNA Features That Classify Schizophrenia Patients Accurately and Highlight Insightful Gene Clusters.
    Autorzy:
    Liu Y; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
    Qu HQ; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
    Chang X; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
    Tian L; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
    Qu J; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
    Glessner J; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
    Sleiman PMA; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
    Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2021 Mar 25; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 25.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Machine Learning*
    Multigene Family*
    Prefrontal Cortex/*metabolism
    RNA, Untranslated/*genetics
    Schizophrenia/*diagnosis
    Schizophrenia/*genetics
    Algorithms ; Biomarkers/metabolism ; Computational Biology/methods ; Diagnosis, Computer-Assisted ; Factor Analysis, Statistical ; Humans ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics ; RNA-Seq ; Transcriptome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia.
    Autorzy:
    Banerjee A; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
    Wang HY; Department of Physiology, Pharmacology and Neuroscience, City University of New York Medical School, New York, NY, USA.
    Borgmann-Winter KE; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
    MacDonald ML; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
    Kaprielian H; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
    Stucky A; Department of Physiology, Pharmacology and Neuroscience, City University of New York Medical School, New York, NY, USA.
    Kvasic J; Department of Physiology, Pharmacology and Neuroscience, City University of New York Medical School, New York, NY, USA.
    Egbujo C; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
    Ray R; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
    Talbot K; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
    Hemby SE; Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
    Siegel SJ; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
    Arnold SE; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
    Sleiman P; The Center for Applied Genomics, The Children's Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Chang X; The Center for Applied Genomics, The Children's Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Hakonarson H; The Center for Applied Genomics, The Children's Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
    Gur RE; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
    Hahn CG; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
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    Źródło:
    Molecular psychiatry [Mol Psychiatry] 2015 Sep; Vol. 20 (9), pp. 1091-100. Date of Electronic Publication: 2014 Oct 21.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Receptors, N-Methyl-D-Aspartate/*metabolism
    Schizophrenia/*genetics
    Schizophrenia/*metabolism
    src-Family Kinases/*metabolism
    Animals ; Brain/metabolism ; Brain/pathology ; Case-Control Studies ; Gene Expression Regulation ; Genome-Wide Association Study ; Humans ; Mice ; Mice, Knockout ; Neuronal Plasticity ; Phosphorylation ; Post-Synaptic Density/genetics ; Post-Synaptic Density/metabolism ; Prefrontal Cortex/metabolism ; Protein Interaction Maps ; Schizophrenia/enzymology ; Schizophrenia/pathology ; Signal Transduction ; src-Family Kinases/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus.
    Autorzy:
    Sleiman P; 1] The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA [2] Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.
    Wang D
    Glessner J
    Hadley D
    Gur RE
    Cohen N
    Li Q
    Hakonarson H
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    Corporate Authors:
    Janssen-CHOP Neuropsychiatric Genomics Working Group
    Źródło:
    Scientific reports [Sci Rep] 2013 Oct 29; Vol. 3, pp. 3075. Date of Electronic Publication: 2013 Oct 29.
    Typ publikacji:
    Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Predisposition to Disease*
    Genome-Wide Association Study*
    Bipolar Disorder/*genetics
    Schizophrenia/*genetics
    Case-Control Studies ; Genetic Loci ; Humans ; Odds Ratio ; Polymorphism, Single Nucleotide
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-16 z 16

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