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Tytuł:
Prevention of diet restriction induced hyperactivity but not body-weight reduction in rats co-treated with tryptophan: relationship with striatal serotonin and dopamine metabolism and serotonin-1A auto-receptor expression.
Autorzy:
Saeed R; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan.
Mahmood K; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan.
Ali SB; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan.
Haleem DJ; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan.
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Źródło:
Nutritional neuroscience [Nutr Neurosci] 2022 Aug; Vol. 25 (8), pp. 1764-1773. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji:
Journal Article
MeSH Terms:
Serotonin*/metabolism
Tryptophan*/metabolism
Animals ; Body Weight ; Diet ; Dopamine ; RNA, Messenger ; Rats ; Weight Loss
Czasopismo naukowe
Tytuł:
Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study.
Autorzy:
Jalal K; HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: .
Khan F; HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Nawaz S; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Afroz R; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Khan K; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Ali SB; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Hao L; Hospital of Chengdu University of Traditional Chinese Medicine, No.39 Shi-er-qiao Road, Chengdu, PR China.
Khan SA; Department of Pharmacy, Kohat University of Science and Technology, KP, Pakistan; Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin,78712, USA.
Kazi M; Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia.
Uddin R; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Haleem DJ; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
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Źródło:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Aug; Vol. 152, pp. 113235. Date of Electronic Publication: 2022 Jun 10.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Anxiety Agents*/pharmacology
Serotonin*/metabolism
Animals ; Body Weight ; Brain ; Hydroxyindoleacetic Acid/metabolism ; Hydroxyindoleacetic Acid/pharmacology ; Lysine/metabolism ; Lysine/pharmacology ; Monoamine Oxidase/metabolism ; Rats ; Tryptophan/metabolism ; Tryptophan/pharmacology
Czasopismo naukowe
Tytuł:
Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats.
Autorzy:
Saeed R; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan.
Mahmood K; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan.
Ali SB; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan.
Haleem DJ; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Pakistan.
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Źródło:
International journal of tryptophan research : IJTR [Int J Tryptophan Res] 2022 Jun 20; Vol. 15, pp. 11786469221104729. Date of Electronic Publication: 2022 Jun 20 (Print Publication: 2022).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex.
Autorzy:
Salman T; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan; Dr. Zafar H. Zaidi Center for Proteomics, University of Karachi, Karachi, 75270, Pakistan. Electronic address: .
Afroz R; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address: .
Nawaz S; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address: .
Mahmood K; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address: .
Haleem DJ; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address: .
Zarina S; Dr. Zafar H. Zaidi Center for Proteomics, University of Karachi, Karachi, 75270, Pakistan. Electronic address: .
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Źródło:
Biochimie [Biochimie] 2021 Dec; Vol. 191, pp. 51-61. Date of Electronic Publication: 2021 Aug 27.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation/*drug effects
Memory/*drug effects
Methylphenidate/*pharmacology
Prefrontal Cortex/*metabolism
Receptor, Serotonin, 5-HT1A/*biosynthesis
Receptors, GABA-A/*biosynthesis
Receptors, N-Methyl-D-Aspartate/*biosynthesis
Serotonin/*metabolism
Animals ; Male ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł:
Brain serotonin in high-fat diet-induced weight gain, anxiety and spatial memory in rats.
Autorzy:
Haleem DJ; Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Science (ICCBS), University of Karachi, Karachi, Pakistan.
Mahmood K; Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Science (ICCBS), University of Karachi, Karachi, Pakistan.
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Źródło:
Nutritional neuroscience [Nutr Neurosci] 2021 Mar; Vol. 24 (3), pp. 226-235. Date of Electronic Publication: 2019 May 22.
Typ publikacji:
Journal Article
MeSH Terms:
Diet, High-Fat*
Weight Gain*
Anxiety/*physiopathology
Brain/*metabolism
Obesity/*metabolism
Serotonin/*metabolism
Spatial Memory/*physiology
Animals ; Male ; Rats, Wistar
Czasopismo naukowe
Tytuł:
Elevated anxiety, hypoactivity, memory deficits, decreases of brain serotonin and 5-HT-1A receptors expression in rats treated with omeprazole.
Autorzy:
Ali SB; Present Address: Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270 Pakistan.
Mahmood K; Present Address: Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270 Pakistan.
Saeed R; Present Address: Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270 Pakistan.
Salman T; Present Address: Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270 Pakistan.
Choudhary MI; Present Address: Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270 Pakistan.
Haleem DJ; Present Address: Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270 Pakistan.
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Źródło:
Toxicological research [Toxicol Res] 2020 Sep 17; Vol. 37 (2), pp. 237-248. Date of Electronic Publication: 2020 Sep 17 (Print Publication: 2021).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Circulating leptin, cortisol and gender differences associated with anorexia or obesity in depression.
Autorzy:
Haleem DJ; Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Science (ICCBS), University of Karachi, Karachi, Pakistan.
Gul S; Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Science (ICCBS), University of Karachi, Karachi, Pakistan.
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Źródło:
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2020 Mar; Vol. 21 (3), pp. 195-202. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anorexia*/metabolism
Depression*/complications
Hydrocortisone*/metabolism
Leptin*/metabolism
Obesity*/complications
Body Mass Index ; Female ; Humans ; Hypothalamo-Hypophyseal System ; Male ; Pituitary-Adrenal System ; Sex Characteristics
Czasopismo naukowe
Tytuł:
Inhibition of hormonal and behavioral effects of stress by tryptophan in rats.
Autorzy:
Gul S; a Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research , University of Karachi , Karachi 75270 , Pakistan.; b Department of Physiology , Wah Medical College , Wah Cantt , Pakistan.
Saleem D; c Department of Biomedical Engineering , Sir Syed University of Engineering and Technology , Karachi 75300 , Pakistan.
Haleem MA; c Department of Biomedical Engineering , Sir Syed University of Engineering and Technology , Karachi 75300 , Pakistan.
Haleem DJ; a Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research , University of Karachi , Karachi 75270 , Pakistan.
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Źródło:
Nutritional neuroscience [Nutr Neurosci] 2019 Jun; Vol. 22 (6), pp. 409-417. Date of Electronic Publication: 2017 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Ghrelin/*blood
Leptin/*blood
Serotonin/*blood
Stress, Psychological/*blood
Tryptophan/*administration & dosage
Animals ; Behavior, Animal/drug effects ; Body Weight/drug effects ; Eating/drug effects ; Male ; Rats, Wistar ; Restraint, Physical
Czasopismo naukowe
Tytuł:
Repeated administration of methylphenidate produces reinforcement and downregulates 5-HT-1A receptor expression in the nucleus accumbens.
Autorzy:
Salman T; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: .
Nawaz S; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Waraich RS; Pathobiochemistry and Molecular Physiology Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Haleem DJ; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2019 Feb 01; Vol. 218, pp. 139-146. Date of Electronic Publication: 2018 Dec 27.
Typ publikacji:
Journal Article
MeSH Terms:
Central Nervous System Stimulants/*pharmacology
Maze Learning/*drug effects
Memory/*drug effects
Methylphenidate/*pharmacology
Nucleus Accumbens/*metabolism
Prefrontal Cortex/*metabolism
Receptor, Serotonin, 5-HT1A/*metabolism
Animals ; Central Nervous System Stimulants/administration & dosage ; Down-Regulation ; Male ; Methylphenidate/administration & dosage ; Nucleus Accumbens/drug effects ; Prefrontal Cortex/drug effects ; Rats ; Receptor, Serotonin, 5-HT1A/chemistry ; Receptor, Serotonin, 5-HT1A/genetics
Czasopismo naukowe
Tytuł:
Serotonin-1A receptor dependent modulation of pain and reward for improving therapy of chronic pain.
Autorzy:
Haleem DJ; Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Science (ICCBS), University of Karachi, Karachi 75270, Pakistan. Electronic address: .
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Źródło:
Pharmacological research [Pharmacol Res] 2018 Aug; Vol. 134, pp. 212-219. Date of Electronic Publication: 2018 Jun 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Reward*
Analgesics/*therapeutic use
Brain/*drug effects
Chronic Pain/*drug therapy
Pain Perception/*drug effects
Pain Threshold/*drug effects
Receptor, Serotonin, 5-HT1A/*drug effects
Serotonin 5-HT1 Receptor Agonists/*therapeutic use
Analgesics/adverse effects ; Analgesics, Opioid/adverse effects ; Animals ; Brain/metabolism ; Brain/physiopathology ; Chronic Pain/metabolism ; Chronic Pain/physiopathology ; Chronic Pain/psychology ; Dopamine/metabolism ; Humans ; Opioid-Related Disorders/metabolism ; Opioid-Related Disorders/physiopathology ; Opioid-Related Disorders/psychology ; Receptor, Serotonin, 5-HT1A/metabolism ; Serotonin 5-HT1 Receptor Agonists/adverse effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Dopamine and serotonin metabolism associated with morphine reward and its inhibition with buspirone: A study in the rat striatum.
Autorzy:
Haleem DJ; Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Science (ICCBS), University of Karachi, Karachi 75270, Pakistan. Electronic address: .
Nawaz S; Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Science (ICCBS), University of Karachi, Karachi 75270, Pakistan.
Salman T; Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine & Drug Research (PCMD), International Center for Chemical and Biological Science (ICCBS), University of Karachi, Karachi 75270, Pakistan.
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Źródło:
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2018 Jul; Vol. 170, pp. 71-78. Date of Electronic Publication: 2018 May 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Reward*
Buspirone/*pharmacology
Corpus Striatum/*metabolism
Dopamine/*metabolism
Morphine/*pharmacology
Morphine Dependence/*metabolism
Serotonin/*metabolism
Animals ; Caudate Nucleus/metabolism ; Male ; Morphine Dependence/prevention & control ; Nucleus Accumbens/metabolism ; Rats ; Rats, Wistar ; Receptor, Serotonin, 5-HT1A/physiology
Czasopismo naukowe
Tytuł:
Neurochemical and behavioral effects of Nigella sativa and Olea europaea oil in rats.
Autorzy:
Cheema MAR; a Neuroscience Research Lab, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences , University of Karachi , Karachi 75270 , Pakistan.
Nawaz S; a Neuroscience Research Lab, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences , University of Karachi , Karachi 75270 , Pakistan.
Gul S; a Neuroscience Research Lab, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences , University of Karachi , Karachi 75270 , Pakistan.
Salman T; a Neuroscience Research Lab, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences , University of Karachi , Karachi 75270 , Pakistan.
Naqvi S; b Pharmacology Section, HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , Karachi 75270 , Pakistan.
Dar A; b Pharmacology Section, HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , Karachi 75270 , Pakistan.
Haleem DJ; a Neuroscience Research Lab, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences , University of Karachi , Karachi 75270 , Pakistan.
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Źródło:
Nutritional neuroscience [Nutr Neurosci] 2018 Apr; Vol. 21 (3), pp. 185-194. Date of Electronic Publication: 2016 Nov 21.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Dietary Supplements*/adverse effects
Learning*
Memory*
Nigella sativa/*chemistry
Nootropic Agents/*therapeutic use
Olea/*chemistry
Plant Oils/*administration & dosage
Animals ; Anti-Anxiety Agents/administration & dosage ; Anti-Anxiety Agents/adverse effects ; Anti-Anxiety Agents/therapeutic use ; Anxiety/prevention & control ; Behavior, Animal ; Brain/metabolism ; Dopamine Agonists/administration & dosage ; Dopamine Agonists/adverse effects ; Dopamine Agonists/therapeutic use ; Ethnopharmacology ; Homovanillic Acid/agonists ; Homovanillic Acid/metabolism ; Male ; Maze Learning ; Medicine, Traditional ; Neurons/metabolism ; Nootropic Agents/administration & dosage ; Nootropic Agents/adverse effects ; Pakistan ; Plant Oils/adverse effects ; Plant Oils/therapeutic use ; Random Allocation ; Rats, Wistar ; Serotonin Receptor Agonists/administration & dosage ; Serotonin Receptor Agonists/adverse effects ; Serotonin Receptor Agonists/therapeutic use
Czasopismo naukowe
Tytuł:
Walnut supplementation reverses the scopolamine-induced memory impairment by restoration of cholinergic function via mitigating oxidative stress in rats: a potential therapeutic intervention for age related neurodegenerative disorders.
Autorzy:
Haider S; Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, -75270, Pakistan. .
Batool Z; Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, -75270, Pakistan.
Ahmad S; Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.
Siddiqui RA; Food Chemistry and Nutrition Science Laboratory, Virginia State University, Petersburg, VA, USA.
Haleem DJ; Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi, Pakistan.
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Źródło:
Metabolic brain disease [Metab Brain Dis] 2018 Feb; Vol. 33 (1), pp. 39-51. Date of Electronic Publication: 2017 Oct 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Juglans*
Cholinergic Agents/*pharmacology
Memory/*drug effects
Memory Disorders/*diet therapy
Neurodegenerative Diseases/*drug therapy
Oxidative Stress/*drug effects
Acetylcholine/pharmacology ; Animals ; Hippocampus/metabolism ; Lipid Peroxidation/drug effects ; Memory Disorders/chemically induced ; Rats, Wistar ; Scopolamine/pharmacology
Czasopismo naukowe
Tytuł:
Antioxidant effects of rice bran oil mitigate repeated haloperidol-induced tardive dyskinesia in male rats.
Autorzy:
Samad N; Department of Biochemistry, Bahauddin Zakariya University, Multan, 60800, Pakistan. .
Haleem DJ; Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi, 75270, Pakistan.
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Źródło:
Metabolic brain disease [Metab Brain Dis] 2017 Aug; Vol. 32 (4), pp. 1099-1107. Date of Electronic Publication: 2017 Apr 03.
Typ publikacji:
Journal Article
MeSH Terms:
Antioxidants/*therapeutic use
Corpus Striatum/*drug effects
Oxidative Stress/*drug effects
Rice Bran Oil/*therapeutic use
Tardive Dyskinesia/*drug therapy
Animals ; Antioxidants/pharmacology ; Behavior, Animal/drug effects ; Catalase/metabolism ; Corpus Striatum/metabolism ; Disease Models, Animal ; Glutathione Peroxidase/metabolism ; Haloperidol ; Lipid Peroxidation/drug effects ; Male ; Malondialdehyde/metabolism ; Motor Activity/drug effects ; Rats ; Rats, Wistar ; Rice Bran Oil/pharmacology ; Superoxide Dismutase/metabolism ; Tardive Dyskinesia/chemically induced ; Tardive Dyskinesia/metabolism
Czasopismo naukowe

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