Temat: "Half-Life" - OpacWWW

Skocz do pozycji: 21.

Tytuł:: Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review.
Autorzy:: Tong L; School of Material Science and Chemical Engineering, Harbin University of Science and Technology, Harbin 150040, China.
Liu D; School of Material Science and Chemical Engineering, Harbin University of Science and Technology, Harbin 150040, China.
Cao Z; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.
Zheng N; School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China.
Mao C; Department of Electrical, Computer and Energy Engineering, University of Colorado Boulder, Boulder, CO 80309, USA.
Liu S; School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.; Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), Harbin Institute of Technology, Harbin 150001, China.
He L; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.; School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China.; Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), Harbin Institute of Technology, Harbin 150001, China.
Liu S; School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.; School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China.; Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), Harbin Institute of Technology, Harbin 150001, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 08; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 08.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Hepatitis B*/drug therapy
Nucleic Acids*
Humans ; RNA, Small Interfering/genetics ; Genetic Therapy/methods ; Half-Life ; Genetic Vectors

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Skocz do pozycji: 22.

Tytuł:: PEGylation Prolongs the Half-Life of Equine Anti-SARS-CoV-2 Specific F(ab') 2 .
Autorzy:: Xu M; College of Veterinary Medicine, Jilin University, Changchun 130062, China.; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.
Bi J; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.; Center of Infectious Disease Research, Westlake University, Hangzhou 310024, China.
Liang B; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.
Wang X; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.; College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Mo R; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.; College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.
Feng N; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.
Yan F; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.
Wang T; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.
Yang S; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.
Zhao Y; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.
Xia X; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130012, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 08; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 08.
Typ publikacji:: Journal Article
MeSH Terms:: SARS-CoV-2*/metabolism
COVID-19*
Animals ; Horses ; Half-Life ; Antibodies ; Enzyme-Linked Immunosorbent Assay ; Immunoglobulin Fab Fragments

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Skocz do pozycji: 23.

Tytuł:: First-in-Human Studies of Pharmacokinetics and Safety of Utreloxastat (PTC857), a Novel 15-Lipooxygenase Inhibitor for the Treatment of Amyotrophic Lateral Sclerosis.
Autorzy:: Gao L; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Giannousis P; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Thoolen M; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Kaushik D; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Latham J; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Tansy A; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Ma J; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Johnston M; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Dali M; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Golden L; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Klein M; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Kong R; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.
Trimmer J; PTC Therapeutics, Inc., South Plainfield, New Jersey, USA.; Pokaż więcej
Źródło:: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2023 Feb; Vol. 12 (2), pp. 141-151. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:: Randomized Controlled Trial; Journal Article
MeSH Terms:: Amyotrophic Lateral Sclerosis*/drug therapy
Humans ; Area Under Curve ; Half-Life ; Double-Blind Method ; Kinetics

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Skocz do pozycji: 24.

Tytuł:: Half-Life Extension and Biodistribution Modulation of Biotherapeutics via Red Blood Cell Hitch-Hiking with Novel Anti-Band 3 Single-Domain Antibodies.
Autorzy:: Nguyen TD; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
Bordeau BM; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
Zhang Y; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
Mattle AG; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
Balthasar JP; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.; 450 Pharmacy Building, Buffalo, NY 14214, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 28; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 28.
Typ publikacji:: Journal Article
MeSH Terms:: Single-Domain Antibodies*
Humans ; Animals ; Mice ; Tissue Distribution ; Tumor Necrosis Factor-alpha/metabolism ; Enzyme-Linked Immunosorbent Assay ; Half-Life

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Skocz do pozycji: 25.

Tytuł:: Switching from standard to extended half-life FVIII prophylaxis in haemophilia A: Comparison of factor product use, bleed rates and pharmacokinetics.
Autorzy:: Nummi V; Department of Hematology, Coagulation Disorders Unit, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.; Research Program in Systems Oncology, Faculty of Medicine, Helsinki University, Helsinki, Finland.
Lehtinen AE; Department of Hematology, Coagulation Disorders Unit, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.; Research Program in Systems Oncology, Faculty of Medicine, Helsinki University, Helsinki, Finland.
Iorio A; Department of Medicine and Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Szanto T; Department of Hematology, Coagulation Disorders Unit, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.; Research Program in Systems Oncology, Faculty of Medicine, Helsinki University, Helsinki, Finland.
Lassila R; Department of Hematology, Coagulation Disorders Unit, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.; Research Program in Systems Oncology, Faculty of Medicine, Helsinki University, Helsinki, Finland.; Pokaż więcej
Źródło:: Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2022 Nov; Vol. 28 (6), pp. e237-e244. Date of Electronic Publication: 2022 Aug 08.
Typ publikacji:: Comparative Study; Journal Article
MeSH Terms:: Hemophilia A*/complications
Hemophilia A*/drug therapy
Adolescent ; Adult ; Aged ; Humans ; Middle Aged ; Young Adult ; Cohort Studies ; Factor VIII/pharmacokinetics ; Half-Life ; Hemorrhage/drug therapy ; Retrospective Studies

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Skocz do pozycji: 26.

Tytuł:: A homodimeric IL-15 superagonist F4RLI with easy preparation, improved half-life, and potent antitumor activities.
Autorzy:: Lv L; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Wang H; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Shi W; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Wang Y; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Zhu W; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Liu Z; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Chen X; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Zheng C; Imbioray (HangZhou) Biomedical Co., Ltd, 139 Qiuyi Road, HangZhou, 310052, China.
Kong W; Department of Gastroenterological Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
Li W; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Zhu J; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Lu H; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China. .; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China. .; Pokaż więcej
Źródło:: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2022 Nov; Vol. 106 (21), pp. 7039-7050. Date of Electronic Publication: 2022 Oct 03.
Typ publikacji:: Journal Article
MeSH Terms:: Biological Products*/pharmacology
Interleukin-15*/agonists
Programmed Cell Death 1 Receptor*/metabolism
Animals ; Humans ; Mice ; Angiogenesis Inhibitors/pharmacology ; B7-H1 Antigen/metabolism ; Bevacizumab/pharmacology ; CD8-Positive T-Lymphocytes ; Cell Line, Tumor ; Half-Life ; Immune Checkpoint Inhibitors/pharmacology ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin G/metabolism ; Immunotherapy/methods ; Antineoplastic Agents/pharmacology

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Skocz do pozycji: 27.

Tytuł:: Clinical outcomes of low-dose pharmacokinetic-guided extended half-life versus low-dose standard half-life factor VIII concentrate prophylaxis in haemophilia A patients.
Autorzy:: Rakmanotham A; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Integrative and Innovative Hematology/Oncology Research Unit, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Moonla C; Division of General Internal Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Center of Excellence in Translational Hematology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Bangkok, Thailand.
Sosothikul D; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Integrative and Innovative Hematology/Oncology Research Unit, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Pokaż więcej
Źródło:: Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2023 Jan; Vol. 29 (1), pp. 156-164. Date of Electronic Publication: 2022 Nov 21.
Typ publikacji:: Journal Article
MeSH Terms:: Hemophilia A*/drug therapy
Hemostatics*/therapeutic use
Humans ; Child ; Adolescent ; Young Adult ; Adult ; Factor VIII/therapeutic use ; Factor VIII/pharmacokinetics ; Half-Life ; Quality of Life ; Prospective Studies ; Hemorrhage/prevention & control ; Hemorrhage/drug therapy ; Hemarthrosis/drug therapy

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Skocz do pozycji: 28.

Tytuł:: Hemodialysis as emergency treatment of a severe baclofen intoxication in a 3 kg dog.
Autorzy:: Gabba L; Division of Small Animal Emergency and Critical Care, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Iannucci C; Division of Small Animal Emergency and Critical Care, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Vigani A; Division of Small Animal Emergency and Critical Care, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.; Pokaż więcej
Źródło:: Veterinary medicine and science [Vet Med Sci] 2023 Jan; Vol. 9 (1), pp. 43-46. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:: Case Reports
MeSH Terms:: Baclofen*/adverse effects
Renal Dialysis*/veterinary
Dogs ; Animals ; Half-Life ; Coma/chemically induced ; Coma/veterinary ; Emergency Treatment/veterinary

Raport

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Skocz do pozycji: 29.

Tytuł:: HOw Patients view Extended half-life products: Impressions from real-world experience (The HOPE study).
Autorzy:: Khair K; The Centre for Outcomes and Experience Research in Children's Health, Illness and Disability (ORCHID), Great Ormond Street Hospital for Children, London, UK.
Pollard D; The KD Haemophilia Centre & Thrombosis Unit, Royal Free Hampstead NHS Trust, London, UK.
Harrison C; Haemophilia & Thrombosis Centre/P100, Royal Hallamshire Hospital, Sheffield, UK.
Hook S; Royal Edinburgh Infirmary, Edinburgh, UK.
O'Driscoll M; School of Health and Education, Middlesex University, London, UK.
Holland M; Haemnet, London, UK.; Pokaż więcej
Źródło:: Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2019 Sep; Vol. 25 (5), pp. 814-820. Date of Electronic Publication: 2019 Jun 10.
Typ publikacji:: Journal Article
MeSH Terms:: Half-Life*
Blood Coagulation Factors/*pharmacology
Hemophilia A/*drug therapy
Adolescent ; Adult ; Blood Coagulation Factors/therapeutic use ; Child ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Infant ; Male ; Middle Aged ; Prospective Studies ; Qualitative Research ; Young Adult

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Skocz do pozycji: 30.

Tytuł:: Dissipation Kinetics and Safety Evaluation of Flonicamid in Four Various Types of Crops.
Autorzy:: Zhang T; National Wolfberry Engineering Research Center, Wolfberry Science Research Institute, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, China.; Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai'an 271018, China.
Xu Y; Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai'an 271018, China.
Zhou X; National Wolfberry Engineering Research Center, Wolfberry Science Research Institute, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, China.
Liang X; National Wolfberry Engineering Research Center, Wolfberry Science Research Institute, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, China.
Bai Y; Research Center of Pesticide Environmental Toxicology, Shandong Agricultural University, Tai'an 271018, China.
Sun F; Research Center of Pesticide Environmental Toxicology, Shandong Agricultural University, Tai'an 271018, China.
Zhang W; Research Center of Pesticide Environmental Toxicology, Shandong Agricultural University, Tai'an 271018, China.
Wang N; Department of Nutrition and Food Hygiene, School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China.
Pang X; Department of Nutrition and Food Hygiene, School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China.
Li Y; National Wolfberry Engineering Research Center, Wolfberry Science Research Institute, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Dec 06; Vol. 27 (23). Date of Electronic Publication: 2022 Dec 06.
Typ publikacji:: Journal Article
MeSH Terms:: Insecticides*/analysis
Pesticide Residues*/analysis
Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Crops, Agricultural/chemistry ; Kinetics ; Chromatography, High Pressure Liquid ; Half-Life

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Skocz do pozycji: 31.

Tytuł:: Review targeted drug delivery systems for norcantharidin in cancer therapy.
Autorzy:: Zhai BT; State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, 712046, China.
Sun J; State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, 712046, China.
Shi YJ; State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, 712046, China.
Zhang XF; State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, 712046, China.
Zou JB; State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, 712046, China.
Cheng JX; State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, 712046, China.
Fan Y; State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, 712046, China.
Guo DY; State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, 712046, China. .
Tian H; Xi'an Hospital of Traditional Chinese Medicine, Xi'an, 710021, China. .; Pokaż więcej
Źródło:: Journal of nanobiotechnology [J Nanobiotechnology] 2022 Dec 03; Vol. 20 (1), pp. 509. Date of Electronic Publication: 2022 Dec 03.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Bridged Bicyclo Compounds, Heterocyclic*
Neoplasms*/drug therapy
United States ; Drug Delivery Systems ; Half-Life ; Biological Availability

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Skocz do pozycji: 32.

Tytuł:: Dissipation and Dietary Risk Assessment of Pydiflumetofen Residues in Soybean.
Autorzy:: Wei L; College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Hou X; College of Science, China Agricultural University, Beijing 100193, China.
Hou Z; College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Yu X; College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Wang X; College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Zhao Q; College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Gao H; College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Liu H; College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Zheng X; College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.
Lu Z; College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Dec 02; Vol. 27 (23). Date of Electronic Publication: 2022 Dec 02.
Typ publikacji:: Journal Article
MeSH Terms:: Tandem Mass Spectrometry*/methods
Pesticide Residues*/analysis
Glycine max/chemistry ; Soil/chemistry ; Risk Assessment ; Half-Life

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Skocz do pozycji: 33.

Tytuł:: Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes.
Autorzy:: White K; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK.
Aldurdunji M; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK.; Department of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Harris J; School of Biosciences, University of Nottingham, Sutton Bonington, UK.
Ortori C; Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, Nottingham, UK.
Paine S; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, UK.; Pokaż więcej
Źródło:: Pharmacology research & perspectives [Pharmacol Res Perspect] 2022 Dec; Vol. 10 (6), pp. e01031.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Pregnanediones*/pharmacology
Anesthetics*/pharmacokinetics
Humans ; Male ; Female ; Animals ; Rats ; Rats, Inbred Lew ; Half-Life

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Skocz do pozycji: 34.

Tytuł:: Safety, Pharmacokinetics, and Pharmacodynamics of CC-90001 (BMS-986360), a c-Jun N-terminal Kinase Inhibitor, in Phase 1 Studies in Healthy Participants.
Autorzy:: Ye Y; Bristol Myers Squibb, Princeton, New Jersey, USA.
Gaudy A; Bristol Myers Squibb, Princeton, New Jersey, USA.
Thomas M; Bristol Myers Squibb, Princeton, New Jersey, USA.
Reyes J; Bristol Myers Squibb, Princeton, New Jersey, USA.
Burkhardt B; Bristol Myers Squibb, Princeton, New Jersey, USA.
Horan G; Bristol Myers Squibb, Princeton, New Jersey, USA.
Liu L; Bristol Myers Squibb, Princeton, New Jersey, USA.
Chen J; Bristol Myers Squibb, Princeton, New Jersey, USA.
Ghosh A; Bristol Myers Squibb, Princeton, New Jersey, USA.
Carayannopoulos LN; Bristol Myers Squibb, Princeton, New Jersey, USA.
Tatosian DA; Bristol Myers Squibb, Princeton, New Jersey, USA.
Palmisano M; Bristol Myers Squibb, Princeton, New Jersey, USA.; Pokaż więcej
Źródło:: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Dec; Vol. 11 (12), pp. 1394-1404. Date of Electronic Publication: 2022 Oct 18.
Typ publikacji:: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: JNK Mitogen-Activated Protein Kinases*
Adult ; Humans ; Healthy Volunteers ; Half-Life ; Dose-Response Relationship, Drug ; Double-Blind Method

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Skocz do pozycji: 35.

Tytuł:: Advanced EPI-X4 Derivatives Covalently Bind Human Serum Albumin Resulting in Prolonged Plasma Stability.
Autorzy:: Rodríguez-Alfonso A; Core Facility Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany.; Core Unit Mass Spectrometry and Proteomics, Ulm University Medical Center, 89081 Ulm, Germany.
Heck A; Max Planck Institute for Polymer Research, 55128 Mainz, Germany.
Ruiz-Blanco YB; Center of Medical Biotechnology, University of Duisburg-Essen, 47057 Duisburg, Germany.
Gilg A; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Ständker L; Core Facility Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany.
Kuan SL; Max Planck Institute for Polymer Research, 55128 Mainz, Germany.
Weil T; Max Planck Institute for Polymer Research, 55128 Mainz, Germany.
Sanchez-Garcia E; Center of Medical Biotechnology, University of Duisburg-Essen, 47057 Duisburg, Germany.
Wiese S; Core Unit Mass Spectrometry and Proteomics, Ulm University Medical Center, 89081 Ulm, Germany.
Münch J; Core Facility Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany.; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Harms M; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 30; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 30.
Typ publikacji:: Journal Article
MeSH Terms:: Serum Albumin, Human*
Receptors, CXCR4*/metabolism
Animals ; Humans ; Peptides/chemistry ; Half-Life ; Serum Albumin/metabolism

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Skocz do pozycji: 36.

Tytuł:: Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.
Autorzy:: Illiano S; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France. .; IRSN, B.P. 17, 92262, Fontenay-Aux-Roses Cedex, France. .
Poirier B; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Minoletti C; Integrated Drug Discovery, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Pasquier O; DMPK France, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Riva L; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Chenede X; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Menguy I; Integrated Drug Discovery, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Guillotel M; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Prigent P; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Le Claire S; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Gillot F; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Thill G; Translational Science, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Lo Presti F; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Corbier A; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Le Bail JC; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Grailhe P; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Monteagudo E; Peptides and Small Molecules R&D Department, ≠DMPK, and Structural Biology IRBM Spa, Via Pontina Km 30 600, 00 071, Pomezia, RM, Italy.
Ingenito R; Peptides and Small Molecules R&D Department, ≠DMPK, and Structural Biology IRBM Spa, Via Pontina Km 30 600, 00 071, Pomezia, RM, Italy.
Bianchi E; Peptides and Small Molecules R&D Department, ≠DMPK, and Structural Biology IRBM Spa, Via Pontina Km 30 600, 00 071, Pomezia, RM, Italy.
Philippo C; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Duclos O; Integrated Drug Discovery, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
Mallart S; Integrated Drug Discovery, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.; Structural biology and chemistry, Institut Pasteur, PARIS, France.
Bathgate R; Florey Institute of Neuroscience and Mental Health and Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC, 3052, Australia.
Janiak P; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Nov 28; Vol. 12 (1), pp. 20435. Date of Electronic Publication: 2022 Nov 28.
Typ publikacji:: Journal Article
MeSH Terms:: Relaxin*/pharmacology
Humans ; Animals ; Rats ; Half-Life ; Renal Circulation ; Models, Molecular ; Administration, Intravenous ; Receptors, Peptide/genetics ; Receptors, G-Protein-Coupled

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Skocz do pozycji: 37.

Tytuł:: Pharmacokinetics of Amoxicillin and Clavulanate Potassium for Suspension (200 mg/28.5 mg) in Healthy Subjects: Sample Add Stabilizer Study and Food Effects.
Autorzy:: Xu SM; Phase I Clinical Trial Center, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.
Qin F; Guangzhou Baiyunshan Pharmaceutical Holdings Co. Ltd., Baiyunshan Pharmaceutical General Factory, Guangzhou, PR China.
Zhang YD; Phase I Clinical Trial Center, The First People's Hospital of Chenzhou, Chenzhou, PR China.
Xu PS; Phase I Clinical Trial Center, Xiangya Hospital, Central South University, Changsha, PR China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, PR China.; Pokaż więcej
Źródło:: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Nov; Vol. 11 (11), pp. 1314-1321. Date of Electronic Publication: 2022 Jul 15.
Typ publikacji:: Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Amoxicillin*/adverse effects
Humans ; Healthy Volunteers ; Area Under Curve ; Clavulanic Acid/adverse effects ; Tablets ; Half-Life ; Administration, Oral ; Cross-Over Studies ; Suspensions

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Skocz do pozycji: 38.

Tytuł:: Plasma and muscle tissue disposition of enrofloxacin in Nile tilapia ( Oreochromis niloticus ) after intravascular, intraperitoneal, and oral administrations.
Autorzy:: Corum O; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkey.
Terzi E; Faculty of Fisheries, University of Kastamonu, Kastamonu, Turkey.
Durna Corum D; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay, Turkey.
Tastan Y; Faculty of Fisheries, University of Kastamonu, Kastamonu, Turkey.
Gonzales RC; Department of Marine Biology and Environmental Science, Mindanao State University Naawan, College of Science and Environment, Naawan, Misamis Oriental, Philippines.
Kenanoglu ON; Faculty of Fisheries, University of Kastamonu, Kastamonu, Turkey.
Arriesgado DM; Department of Fisheries, Faculty of Fisheries, Mindanao State University Naawan, Naawan, Misamis Oriental, Philippines.
Navarro VR; Department of Fisheries, Faculty of Fisheries, Mindanao State University Naawan, Naawan, Misamis Oriental, Philippines.
Bilen S; Faculty of Fisheries, University of Kastamonu, Kastamonu, Turkey.
Sonmez AY; Faculty of Fisheries, University of Kastamonu, Kastamonu, Turkey.
Uney K; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey.; Pokaż więcej
Źródło:: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment [Food Addit Contam Part A Chem Anal Control Expo Risk Assess] 2022 Nov; Vol. 39 (11), pp. 1806-1817. Date of Electronic Publication: 2022 Sep 22.
Typ publikacji:: Journal Article
MeSH Terms:: Fluoroquinolones*
Cichlids*/metabolism
Animals ; Enrofloxacin/metabolism ; Ciprofloxacin/metabolism ; Administration, Oral ; Muscles/metabolism ; Bacteria/metabolism ; Half-Life

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Skocz do pozycji: 39.

Tytuł:: LongHest project: A prospective, observational study of extended half-life treatment in the musculoskeletal health of patients with severe haemophilia A.
Autorzy:: Cuesta-Barriuso R; Department of Surgery and Medical-Surgical Specialties, Faculty of Medicine, University of Oviedo, Oviedo, Spain.; Royal Victoria Eugenia Foundation, Madrid, Spain.
Pérez-Llanes R; Department of Physiotherapy, Catholic University San Antonio-UCAM, Murcia, Spain.
Donoso-Úbeda E; Department of Physiotherapy, Catholic University San Antonio-UCAM, Murcia, Spain.
Ucero-Lozano R; Department of Physiotherapy, European University of Madrid, Madrid, Spain.; Pokaż więcej
Źródło:: Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2022 Sep; Vol. 28 (5), pp. 857-864. Date of Electronic Publication: 2022 May 13.
Typ publikacji:: Journal Article; Observational Study
MeSH Terms:: Hemophilia A*/complications
Hemophilia A*/drug therapy
Adult ; Half-Life ; Hemarthrosis/etiology ; Hemarthrosis/prevention & control ; Humans ; Pain/etiology ; Prospective Studies

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Skocz do pozycji: 40.

Tytuł:: Clinical application of extended half-life factor VIII in children with severe haemophilia A.
Autorzy:: Dettoraki A; Haemophilia Centre/Haemostasis and Thrombosis Unit, 'Aghia Sophia' Children's Hospital, Athens, Greece.
Michalopoulou A; Haemophilia Centre/Haemostasis and Thrombosis Unit, 'Aghia Sophia' Children's Hospital, Athens, Greece.
Mazarakis M; Haemophilia Centre/Haemostasis and Thrombosis Unit, 'Aghia Sophia' Children's Hospital, Athens, Greece.
Saslis S; Haemophilia Centre/Haemostasis and Thrombosis Unit, 'Aghia Sophia' Children's Hospital, Athens, Greece.
Stamati I; Haemophilia Centre/Haemostasis and Thrombosis Unit, 'Aghia Sophia' Children's Hospital, Athens, Greece.
Kapsimali Z; Haemophilia Centre/Haemostasis and Thrombosis Unit, 'Aghia Sophia' Children's Hospital, Athens, Greece.
Pergantou H; Haemophilia Centre/Haemostasis and Thrombosis Unit, 'Aghia Sophia' Children's Hospital, Athens, Greece.; Pokaż więcej
Źródło:: Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2022 Jul; Vol. 28 (4), pp. 619-624. Date of Electronic Publication: 2022 May 03.
Typ publikacji:: Journal Article
MeSH Terms:: Hemophilia A*/drug therapy
Hemostatics*/therapeutic use
Child ; Child, Preschool ; Factor VIII/pharmacology ; Half-Life ; Hemarthrosis ; Hemorrhage/drug therapy ; Hemorrhage/etiology ; Hemorrhage/prevention & control ; Humans ; Retrospective Studies

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