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    Tytuł:
    Role of cardiac mitofusins in cardiac conduction following simulated ischemia-reperfusion.
    Autorzy:
    Kwek XY; National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.
    Hall AR; The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK.
    Lim WW; National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.
    Katwadi K; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.
    Soong PL; Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore.; Cardiovascular Translational Program, Cardiovascular Research Institute (CVRI), National University of Singapore, Singapore, Singapore.; Department of Medicine, National University Hospital of Singapore (NUHS), Singapore, Singapore.; Ternion Biosciences, Singapore, Singapore.
    Grishina E; Ternion Biosciences, Singapore, Singapore.
    Lin KH; Ternion Biosciences, Singapore, Singapore.
    Crespo-Avilan G; National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.; Department of Biochemistry, Medical Faculty, Justus Liebig-University, Giessen, Germany.
    Yap EP; National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.
    Ismail NI; Centre for Cardiovascular Genomics and Medicine (CCGM), Lui Che Woo Institute of Innovative Medicine, Chinese University of Hong Kong (CUHK), Hong Kong, SAR, China.; Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong (CUHK), Hong Kong, SAR, China.; Hong Kong Hub of Paediatric Excellence (HK HOPE), Hong Kong Children's Hospital (HKCH), Kowloon Bay, Hong Kong, SAR, China.
    Chinda K; Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.; Integrative Cardiovascular Research Unit, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
    Chung YY; Centre for Vision Research, Duke-National University of Singapore Medical School, Singapore, Singapore.
    Wei H; Research Laboratory, KK Women's & Children's Hospital, Singapore, Singapore.
    Shim W; Health and Social Sciences Cluster, Singapore Institute of Technology, Singapore, Singapore.
    Montaigne D; Inserm, CHU Lille, Institut Pasteur Lille, U1011-European Genomic Institute for Diabetes (EGID), University of Lille, 59000, Lille, France.
    Tinker A; Centre for Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
    Ong SB; Centre for Cardiovascular Genomics and Medicine (CCGM), Lui Che Woo Institute of Innovative Medicine, Chinese University of Hong Kong (CUHK), Hong Kong, SAR, China. .; Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong (CUHK), Hong Kong, SAR, China. .; Hong Kong Hub of Paediatric Excellence (HK HOPE), Hong Kong Children's Hospital (HKCH), Kowloon Bay, Hong Kong, SAR, China. .; Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Kunming Institute of Zoology-The Chinese University of Hong Kong (KIZ-CUHK), Chinese Academy of Sciences, Kunming, Yunnan, China. .; Shenzhen Research Institute (SZRI), Chinese University of Hong Kong (CUHK), Shenzhen, China. .
    Hausenloy DJ; National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore. .; The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK. .; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore. .; Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore. .
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    Źródło:
    Scientific reports [Sci Rep] 2022 Dec 06; Vol. 12 (1), pp. 21049. Date of Electronic Publication: 2022 Dec 06.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Bone Density Conservation Agents*
    Craniocerebral Trauma*
    Mice ; Animals ; Cardiac Electrophysiology ; Ischemia
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation.
    Autorzy:
    Hall AR; The Hatter Cardiovascular Institute, University College London, London, UK.
    Karwi QG; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
    Kumar S; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
    Dongworth R; The Hatter Cardiovascular Institute, University College London, London, UK.
    Aksentijević D; William Harvey Research Institute, Centre for Biochemical Pharmacology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
    Altamimi TR; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
    Fridianto KT; Cardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore.
    Chinda K; Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
    Hernandez-Resendiz S; National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.; Department of Medicine, University of Alberta, Edmonton, AB, T6G 2B7, Canada.
    Mahmood MU; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
    Michelakis E; School of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Research Excellence, King's College London, The Rayne Institute, St Thomas' Hospital, London, UK.
    Ramachandra CJ; Cardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore.; National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.
    Ching J; Cardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore.
    Vicencio JM; The Hatter Cardiovascular Institute, University College London, London, UK.
    Shattock MJ; School of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Research Excellence, King's College London, The Rayne Institute, St Thomas' Hospital, London, UK.
    Kovalik JP; Cardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore.
    Yellon DM; The Hatter Cardiovascular Institute, University College London, London, UK.
    Lopaschuk G; Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
    Hausenloy DJ; The Hatter Cardiovascular Institute, University College London, London, UK. .; Cardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore. .; National Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore. .; Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore. .; Chengdu University, Chengdu, China. .
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    Źródło:
    Scientific reports [Sci Rep] 2022 Nov 29; Vol. 12 (1), pp. 20551. Date of Electronic Publication: 2022 Nov 29.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Myocardial Reperfusion Injury*/genetics
    Sirtuin 3*/genetics
    Animals ; Mice ; Fasting ; Fatty Acids ; Glucose ; Mice, Knockout
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Tissue-Specific Human Extracellular Matrix Scaffolds Promote Pancreatic Tumour Progression and Chemotherapy Resistance.
    Autorzy:
    Al-Akkad W; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.; Engitix Therapeutics, The Westworks, 195 Wood Lane, Shepherd's Bush, London W12 7FQ, UK.
    Acedo P; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.
    Vilia MG; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.; Engitix Therapeutics, The Westworks, 195 Wood Lane, Shepherd's Bush, London W12 7FQ, UK.
    Frenguelli L; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.; Engitix Therapeutics, The Westworks, 195 Wood Lane, Shepherd's Bush, London W12 7FQ, UK.
    Ney A; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.
    Rodriguez-Hernandez I; Engitix Therapeutics, The Westworks, 195 Wood Lane, Shepherd's Bush, London W12 7FQ, UK.
    Labib PL; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.
    Tamburrino D; Division of Surgery, Royal Free London NHS Foundation Trust, University College London, London NW3 2QG, UK.
    Spoletini G; Division of Surgery, Royal Free London NHS Foundation Trust, University College London, London NW3 2QG, UK.
    Hall AR; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.; Sheila Sherlock Liver Centre, Royal Free London NHS Foundation Trust, London NW3 2PF, UK.
    Canestrari S; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.
    Osnato A; Wellcome Trust-MRC Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge CB2 0AW, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1RQ, UK.
    Garcia-Bernardo J; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1RQ, UK.
    Sejour L; Cancer Research Institute, HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Vassileva V; Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.
    Vlachos IS; Cancer Research Institute, HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Fusai G; Division of Surgery, Royal Free London NHS Foundation Trust, University College London, London NW3 2QG, UK.
    Luong TV; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.; Sheila Sherlock Liver Centre, Royal Free London NHS Foundation Trust, London NW3 2PF, UK.
    Whittaker SR; Engitix Therapeutics, The Westworks, 195 Wood Lane, Shepherd's Bush, London W12 7FQ, UK.
    Pereira SP; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.
    Vallier L; Wellcome Trust-MRC Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge CB2 0AW, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1RQ, UK.
    Pinzani M; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.
    Rombouts K; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.
    Mazza G; UCL Institute for Liver and Digestive Health, Royal Free Hospital, University College London, London NW3 2PF, UK.; Engitix Therapeutics, The Westworks, 195 Wood Lane, Shepherd's Bush, London W12 7FQ, UK.
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    Źródło:
    Cells [Cells] 2022 Nov 17; Vol. 11 (22). Date of Electronic Publication: 2022 Nov 17.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Pancreatic Neoplasms*/pathology
    Carcinoma, Pancreatic Ductal*/metabolism
    Adenocarcinoma*/metabolism
    Humans ; Cell Line, Tumor ; Pancreas/pathology ; Extracellular Matrix/metabolism ; Pancreatic Neoplasms
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Histological sub-classification of cirrhosis using collagen proportionate area in patients with chronic hepatitis C.
    Autorzy:
    Papatheodoridi M; UCL Institute of Liver and Digestive Health, Royal Free Hospital, London, UK.
    Hall AR; Academic department of Histopathology, UCL, London, UK.
    Rodríguez-Perálvarez M; UCL Institute of Liver and Digestive Health, Royal Free Hospital, London, UK.
    Pieri G; UCL Institute of Liver and Digestive Health, Royal Free Hospital, London, UK.
    Germani G; UCL Institute of Liver and Digestive Health, Royal Free Hospital, London, UK.
    Gale JD; Inflammation and Immunology Research Unit, Pfizer Inc., Cambridge, MA, USA.
    Burgess GC; GCB Clinical Consulting Ltd, Canterbury, UK.
    Pinzani M; UCL Institute of Liver and Digestive Health, Royal Free Hospital, London, UK.
    Dhillon AP; Academic department of Histopathology, UCL, London, UK.
    Tsochatzis EA; UCL Institute of Liver and Digestive Health, Royal Free Hospital, London, UK.
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    Źródło:
    Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2021 Jul; Vol. 41 (7), pp. 1608-1613. Date of Electronic Publication: 2021 May 07.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    End Stage Liver Disease*
    Esophageal and Gastric Varices*
    Hepatitis C, Chronic*/complications
    Collagen ; Gastrointestinal Hemorrhage ; Humans ; Liver Cirrhosis ; Severity of Illness Index
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition.
    Autorzy:
    Mazza G; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Telese A; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Al-Akkad W; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Frenguelli L; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Levi A; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Marrali M; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Longato L; Engitix Ltd., London NW3 2PF, UK.
    Thanapirom K; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Vilia MG; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Lombardi B; Proteomics and Molecular Cell Dynamics, Centre for Nephrology, School of Life and Medical Sciences, University College London, London NW3 2PF, UK.
    Crowley C; Stem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Programme, UCL Institute for Child Health, Great Ormond Street Hospital, University College London, London WC1N 3JH, UK.
    Crawford M; Proteomics and Molecular Cell Dynamics, Centre for Nephrology, School of Life and Medical Sciences, University College London, London NW3 2PF, UK.
    Karsdal MA; Nordic Bioscience, Biomarkers & Research, Herlev Hovedgade 205-207, 2730 Herlev, Denmark.
    Leeming DJ; Nordic Bioscience, Biomarkers & Research, Herlev Hovedgade 205-207, 2730 Herlev, Denmark.
    Marrone G; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Bottcher K; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Robinson B; Department of Bioengineering, Cellular and Molecular Biomechanics. Imperial College, London SW7 2AZ, UK.
    Del Rio Hernandez A; Department of Bioengineering, Cellular and Molecular Biomechanics. Imperial College, London SW7 2AZ, UK.
    Tamburrino D; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Spoletini G; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Malago M; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
    Hall AR; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.; Sheila Sherlock Liver Centre, Royal Free London NHS foundation trust, NW3 2PF London, UK.
    Godovac-Zimmermann J; Proteomics and Molecular Cell Dynamics, Centre for Nephrology, School of Life and Medical Sciences, University College London, London NW3 2PF, UK.
    Luong TV; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.; Sheila Sherlock Liver Centre, Royal Free London NHS foundation trust, NW3 2PF London, UK.
    De Coppi P; Stem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Programme, UCL Institute for Child Health, Great Ormond Street Hospital, University College London, London WC1N 3JH, UK.; Specialist Neonatal and Paediatric Surgery at Great Ormond Street Hospital, London WC1N 1EH, UK.
    Pinzani M; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.; Sheila Sherlock Liver Centre, Royal Free London NHS foundation trust, NW3 2PF London, UK.
    Rombouts K; Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
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    Źródło:
    Cells [Cells] 2019 Dec 28; Vol. 9 (1). Date of Electronic Publication: 2019 Dec 28.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Epithelial-Mesenchymal Transition*
    Tissue Scaffolds*
    Extracellular Matrix/*metabolism
    Liver Cirrhosis/*metabolism
    Liver Cirrhosis/*pathology
    Smad Proteins/*metabolism
    Transforming Growth Factor beta1/*metabolism
    Bioengineering ; Carcinoma, Hepatocellular/etiology ; Collagen/metabolism ; Humans ; Immunohistochemistry ; Liver Cirrhosis/etiology ; Phosphorylation ; Proteomics ; Signal Transduction ; Smad2 Protein/metabolism ; Smad3 Protein/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography.
    Autorzy:
    Beikoghli Kalkhoran S; The Hatter Cardiovascular Institute University College London, London, United Kingdom.; The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, United Kingdom.; Institute of Cardiovascular Science, University College London, London, United Kingdom.
    Hall AR; The Hatter Cardiovascular Institute University College London, London, United Kingdom.; The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, United Kingdom.; Institute of Cardiovascular Science, University College London, London, United Kingdom.
    White IJ; MRC Laboratory of Molecular Cell Biology University College London, London, United Kingdom.
    Cooper J; Institute of Cardiovascular Science, University College London, London, United Kingdom.
    Fan Q; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore.
    Ong SB; Cardiovascular and Metabolic Disorder Programme, Duke-NUS Medical School, Singapore.; National Heart Research Institute Singapore National Heart Centre Singapore, Singapore.
    Hernández-Reséndiz S; Cardiovascular and Metabolic Disorder Programme, Duke-NUS Medical School, Singapore.; National Heart Research Institute Singapore National Heart Centre Singapore, Singapore.
    Cabrera-Fuentes H; Cardiovascular and Metabolic Disorder Programme, Duke-NUS Medical School, Singapore.; National Heart Research Institute Singapore National Heart Centre Singapore, Singapore.
    Chinda K; Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
    Chakraborty B; Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore.
    Dorn GW 2nd; Centre for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.
    Yellon DM; The Hatter Cardiovascular Institute University College London, London, United Kingdom.; The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, United Kingdom.; Institute of Cardiovascular Science, University College London, London, United Kingdom.
    Hausenloy DJ; The Hatter Cardiovascular Institute University College London, London, United Kingdom .; The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, United Kingdom.; Institute of Cardiovascular Science, University College London, London, United Kingdom.; Cardiovascular and Metabolic Disorder Programme, Duke-NUS Medical School, Singapore.; National Heart Research Institute Singapore National Heart Centre Singapore, Singapore.; Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.; Yong Loo Lin School of Medicine, National University Singapore, Singapore.
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    Źródło:
    Physiological reports [Physiol Rep] 2017 Sep; Vol. 5 (17).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    GTP Phosphohydrolases/*deficiency
    Mitochondria, Muscle/*ultrastructure
    Myocytes, Cardiac/*ultrastructure
    Animals ; Electron Microscope Tomography/methods ; GTP Phosphohydrolases/genetics ; Imaging, Three-Dimensional/methods ; Mice ; Mitochondria, Muscle/metabolism ; Myocytes, Cardiac/metabolism ; Sarcoplasmic Reticulum/metabolism ; Sarcoplasmic Reticulum/ultrastructure
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Amyloid persistence in decellularized liver: biochemical and histopathological characterization.
    Autorzy:
    Mazza G; a Institute for Liver and Digestive Health .
    Simons JP; b Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins , and.
    Al-Shawi R; c Centre for Biomedical Science, Division of Medicine, University College London , London , UK .
    Ellmerich S; b Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins , and.
    Urbani L; d Stem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Programme, UCL Institute for Child Health, Great Ormond Street Hospital, University College London , London UK .
    Giorgetti S; e Department of Molecular Medicine , Institute of Biochemistry, University of Pavia , Pavia , Italy , and.
    Taylor GW; b Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins , and.
    Gilbertson JA; b Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins , and.
    Hall AR; a Institute for Liver and Digestive Health .
    Al-Akkad W; a Institute for Liver and Digestive Health .
    Dhar D; a Institute for Liver and Digestive Health .; f Organ Transplantation Centre and Comparative Medicine Department, King Faisal Specialist Hospital , Riyadh , Saudi Arabia.
    Hawkins PN; b Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins , and.
    De Coppi P; d Stem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Programme, UCL Institute for Child Health, Great Ormond Street Hospital, University College London , London UK .
    Pinzani M; a Institute for Liver and Digestive Health .
    Bellotti V; b Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins , and.; e Department of Molecular Medicine , Institute of Biochemistry, University of Pavia , Pavia , Italy , and.
    Mangione PP; b Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins , and.; e Department of Molecular Medicine , Institute of Biochemistry, University of Pavia , Pavia , Italy , and.
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    Źródło:
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2016; Vol. 23 (1), pp. 1-7. Date of Electronic Publication: 2015 Dec 08.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Amyloid/*physiology
    Amyloidosis/*pathology
    Liver/*pathology
    Liver Diseases/*pathology
    Amino Acid Sequence ; Amyloid/chemistry ; Animals ; Extracellular Matrix/physiology ; Female ; Immunoglobulin Light-chain Amyloidosis ; Liver/chemistry ; Mice, Inbred C57BL ; Mice, Transgenic ; Molecular Sequence Data ; Serum Amyloid A Protein/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Mitochondrial respiratory inhibition by 2,3-butanedione monoxime (BDM): implications for culturing isolated mouse ventricular cardiomyocytes.
    Autorzy:
    Hall AR; The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London Hospital & Medical School, London, UK andrew.r.hall@ucl.ac.uk.
    Hausenloy DJ; The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London Hospital & Medical School, London, UK Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore, Singapore National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
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    Źródło:
    Physiological reports [Physiol Rep] 2016 Jan; Vol. 4 (1).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Diacetyl/*analogs & derivatives
    Mitochondria, Heart/*drug effects
    Mitochondria, Heart/*metabolism
    Myocytes, Cardiac/*drug effects
    Myocytes, Cardiac/*metabolism
    Animals ; Cell Culture Techniques/methods ; Cell Respiration/drug effects ; Cell Respiration/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Cells, Cultured ; Diacetyl/pharmacology ; Enzyme Inhibitors/pharmacology ; Mice ; Mice, Inbred C57BL
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Evidence that selenium binding protein 1 is a tumor suppressor in prostate cancer.
    Autorzy:
    Ansong E; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Ying Q; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, United States of America; College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China; Department of Pathology, Xinxiang Medical University, Xinxiang, China.
    Ekoue DN; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Deaton R; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Hall AR; University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Kajdacsy-Balla A; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Yang W; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, United States of America; Department of Pathology, Xinxiang Medical University, Xinxiang, China.
    Gann PH; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, United States of America.
    Diamond AM; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, United States of America.
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    Źródło:
    PloS one [PLoS One] 2015 May 18; Vol. 10 (5), pp. e0127295. Date of Electronic Publication: 2015 May 18 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genes, Tumor Suppressor*
    Biomarkers, Tumor/*metabolism
    Prostatic Neoplasms/*pathology
    Prostatic Neoplasms/*surgery
    Selenium-Binding Proteins/*metabolism
    Cell Nucleus/metabolism ; Cell Proliferation ; Cytoplasm/metabolism ; HCT116 Cells ; Humans ; Male ; Neoplasm Recurrence, Local ; Prognosis ; Prostatectomy ; Prostatic Neoplasms/metabolism ; Tissue Array Analysis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The use of guideline images to improve histological estimation of hepatic steatosis.
    Autorzy:
    Hall AR; The Department of Cellular Pathology, Royal Free London NHS Foundation Trust, London, UK.
    Green AC
    Luong TV
    Burroughs AK
    Wyatt J
    Dhillon AP
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    Źródło:
    Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2014 Oct; Vol. 34 (9), pp. 1414-27. Date of Electronic Publication: 2014 Jul 08.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Adipose Tissue/*pathology
    Fatty Liver/*diagnosis
    Fatty Liver/*pathology
    Histological Techniques/*methods
    Photomicrography/*standards
    Biopsy/methods ; Humans ; Image Processing, Computer-Assisted ; Photomicrography/methods ; Statistics, Nonparametric ; United Kingdom
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Hepatic steatosis estimated microscopically versus digital image analysis.
    Autorzy:
    Hall AR; Department of Cellular Pathology, Royal Free London NHS Foundation Trust, London, UK. />Dhillon AP
    Green AC
    Ferrell L
    Crawford JM
    Alves V
    Balabaud C
    Bhathal P
    Bioulac-Sage P
    Guido M
    Hytiroglou P
    Nakanuma Y
    Paradis V
    Quaglia A
    Snover D
    Theise N
    Thung S
    Tsui W
    van Leeuwen DJ
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    Źródło:
    Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2013 Jul; Vol. 33 (6), pp. 926-35. Date of Electronic Publication: 2013 Apr 07.
    Typ publikacji:
    Journal Article; Multicenter Study
    MeSH Terms:
    Adiposity*
    Image Interpretation, Computer-Assisted*
    Microscopy*
    Fatty Liver/*pathology
    Liver/*pathology
    Asia ; Biopsy ; Brazil ; Consensus ; Europe ; Humans ; Observer Variation ; Predictive Value of Tests ; Reproducibility of Results ; Severity of Illness Index ; United States
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury.
    Autorzy:
    Siddall HK; The Hatter Cardiovascular Institute, University College London, London, United Kingdom.
    Yellon DM
    Ong SB
    Mukherjee UA
    Burke N
    Hall AR
    Angelova PR
    Ludtmann MH
    Deas E
    Davidson SM
    Mocanu MM
    Hausenloy DJ
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    Źródło:
    PloS one [PLoS One] 2013 Apr 29; Vol. 8 (4), pp. e62400. Date of Electronic Publication: 2013 Apr 29 (Print Publication: 2013).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Myocardium/*metabolism
    Protein Kinases/*deficiency
    Reperfusion Injury/*enzymology
    Animals ; Cell Line ; Disease Susceptibility ; Gene Knockout Techniques ; Membrane Potential, Mitochondrial ; Mice ; Mitochondria/metabolism ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Permeability Transition Pore ; Myocardium/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Oxidative Stress ; Oxygen/metabolism ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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