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Wyświetlanie 1-12 z 12
Tytuł :
Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis.
Autorzy :
Pijuan-Sala B; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Wilson NK; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Xia J; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Hou X; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA.
Hannah RL; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Kinston S; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Calero-Nieto FJ; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Poirion O; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA.
Preissl S; Center for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA.
Liu F; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Göttgens B; Department of Haematology, University of Cambridge, Cambridge, UK. .; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2020 Apr; Vol. 22 (4), pp. 487-497. Date of Electronic Publication: 2020 Mar 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer Elements, Genetic*
Gene Expression Regulation, Developmental*
Chromatin/*chemistry
Endothelial Cells/*metabolism
Organogenesis/*genetics
T-Cell Acute Lymphocytic Leukemia Protein 1/*genetics
Animals ; Cell Lineage/genetics ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Chromatin/metabolism ; Embryo, Mammalian ; Embryo, Nonmammalian ; Embryonic Development ; Endothelial Cells/cytology ; Gene Expression Profiling ; Mice ; Mice, Transgenic ; Organ Specificity ; Protein Binding ; Single-Cell Analysis ; T-Cell Acute Lymphocytic Leukemia Protein 1/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic ; Zebrafish ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
Czasopismo naukowe
Tytuł :
An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability.
Autorzy :
Schütte J; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Wang H; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Antoniou S; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Jarratt A; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Wilson NK; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Riepsaame J; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Calero-Nieto FJ; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Moignard V; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Basilico S; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Kinston SJ; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Hannah RL; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Chan MC; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Nürnberg ST; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge, United Kingdom.
Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge, United Kingdom.
Bonzanni N; IBIVU Centre for Integrative Bioinformatics, VU University Amsterdam, Amsterdam, Netherlands.; Netherlands Cancer Institute, Amsterdam, Netherlands.
de Bruijn MF; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Göttgens B; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
ELife [Elife] 2016 Feb 22; Vol. 5, pp. e11469. Date of Electronic Publication: 2016 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Gene Regulatory Networks*
Hematopoiesis*
Hematopoietic Stem Cells/*physiology
Transcription Factors/*metabolism
Animals ; Cell Line ; Chromatin Immunoprecipitation ; Computer Simulation ; Gene Expression Profiling ; Mice ; Models, Theoretical ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.
Autorzy :
Goldberg L; Cancer Research Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel;
Tijssen MR
Birger Y
Hannah RL
Kinston SJ
Schütte J
Beck D
Knezevic K
Schiby G
Jacob-Hirsch J
Biran A
Kloog Y
Marcucci G
Bloomfield CD
Aplan PD
Pimanda JE
Göttgens B
Izraeli S
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Źródło :
Blood [Blood] 2013 Oct 10; Vol. 122 (15), pp. 2694-703. Date of Electronic Publication: 2013 Aug 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Leukemic/*physiology
Leukemia, Myeloid, Acute/*genetics
Proto-Oncogene Proteins c-pim-1/*metabolism
Trans-Activators/*genetics
Transcription Factors/*metabolism
Animals ; Antineoplastic Agents ; Enhancer Elements, Genetic/genetics ; Genomics ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mice, Transgenic ; Myeloid Progenitor Cells/physiology ; Neoplasm Transplantation ; Transcription, Genetic/physiology ; Transcriptional Regulator ERG
Czasopismo naukowe
Tytuł :
The transcription factor Erg controls endothelial cell quiescence by repressing activity of nuclear factor (NF)-κB p65.
Autorzy :
Dryden NH; National Heart and Lung Institute Cardiovascular Sciences Unit, Hammersmith Hospital, Imperial College London, London W12 0NN, UK.
Sperone A
Martin-Almedina S
Hannah RL
Birdsey GM
Khan ST
Layhadi JA
Mason JC
Haskard DO
Göttgens B
Randi AM
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2012 Apr 06; Vol. 287 (15), pp. 12331-42. Date of Electronic Publication: 2012 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Human Umbilical Vein Endothelial Cells/*physiology
Trans-Activators/*physiology
Transcription Factor RelA/*metabolism
Binding Sites ; Binding, Competitive ; Cells, Cultured ; DNA/chemistry ; Electrophoretic Mobility Shift Assay ; Gene Expression Profiling ; Genes, Reporter ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Luciferases, Renilla/biosynthesis ; Luciferases, Renilla/genetics ; Promoter Regions, Genetic ; Protein Binding ; Resting Phase, Cell Cycle ; Trans-Activators/chemistry ; Trans-Activators/metabolism ; Transcription Initiation Site ; Transcription, Genetic ; Transcriptional Regulator ERG
Czasopismo naukowe
Tytuł :
Integration of Elf-4 into stem/progenitor and erythroid regulatory networks through locus-wide chromatin studies coupled with in vivo functional validation.
Autorzy :
Smith AM; University of Cambridge Department of Haematology, Cambridge Institute for Medical Research, Cambridge, United Kingdom. />Calero-Nieto FJ
Schütte J
Kinston S
Timms RT
Wilson NK
Hannah RL
Landry JR
Göttgens B
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2012 Feb; Vol. 32 (4), pp. 763-73. Date of Electronic Publication: 2011 Dec 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
DNA-Binding Proteins/*genetics
DNA-Binding Proteins/*metabolism
Hematopoiesis/*genetics
Hematopoietic Stem Cells/*metabolism
Transcription Factors/*genetics
Transcription Factors/*metabolism
Animals ; Base Sequence ; Chromatin Immunoprecipitation ; Conserved Sequence ; DNA/genetics ; Embryonic Development/genetics ; Enhancer Elements, Genetic ; Erythropoiesis/genetics ; Gene Regulatory Networks ; Mice ; Mice, Transgenic ; Molecular Sequence Data ; Oligonucleotide Array Sequence Analysis ; Promoter Regions, Genetic ; Sequence Homology, Nucleic Acid
Czasopismo naukowe
Tytuł :
The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells.
Autorzy :
Chan WI; Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom.
Hannah RL
Dawson MA
Pridans C
Foster D
Joshi A
Göttgens B
Van Deursen JM
Huntly BJ
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2011 Dec; Vol. 31 (24), pp. 5046-60. Date of Electronic Publication: 2011 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cells/*cytology
Membrane Proteins/*metabolism
Phosphoproteins/*metabolism
Adult Stem Cells/metabolism ; Animals ; Apoptosis ; Cell Differentiation ; Cell Proliferation ; Chromatin Immunoprecipitation ; Flow Cytometry ; Gene Deletion ; Gene Expression Regulation ; Hematopoiesis ; Hematopoietic Stem Cells/metabolism ; Membrane Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Oligonucleotide Array Sequence Analysis ; Phosphoproteins/genetics ; Real-Time Polymerase Chain Reaction ; Sequence Analysis, DNA ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.
Autorzy :
Tijssen MR; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
Cvejic A
Joshi A
Hannah RL
Ferreira R
Forrai A
Bellissimo DC
Oram SH
Smethurst PA
Wilson NK
Wang X
Ottersbach K
Stemple DL
Green AR
Ouwehand WH
Göttgens B
Pokaż więcej
Źródło :
Developmental cell [Dev Cell] 2011 May 17; Vol. 20 (5), pp. 597-609.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Core Binding Factor Alpha 2 Subunit/*metabolism
GATA1 Transcription Factor/*metabolism
GATA2 Transcription Factor/*metabolism
Genome, Human/*genetics
Megakaryocytes/*metabolism
Proto-Oncogene Protein c-fli-1/*metabolism
Proto-Oncogene Proteins/*metabolism
Binding Sites ; Cell Differentiation ; Cells, Cultured ; Humans ; Megakaryocytes/cytology ; Oligonucleotide Array Sequence Analysis ; T-Cell Acute Lymphocytic Leukemia Protein 1
Czasopismo naukowe
Tytuł :
The effect of the Senior Citizens' Freedom to Work Act of 2000 on employer-provided pension and medical plans.
Autorzy :
Baum CL
Hannah RL
Ford WF
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Źródło :
Benefits quarterly [Benefits Q] 2002; Vol. 18 (2), pp. 65-72.
Typ publikacji :
Journal Article
MeSH Terms :
Pensions*
Employment/*legislation & jurisprudence
Health Benefit Plans, Employee/*legislation & jurisprudence
Social Security/*legislation & jurisprudence
Aged ; Decision Making ; Health Benefit Plans, Employee/organization & administration ; Humans ; Salaries and Fringe Benefits ; Social Security/economics ; United States
Czasopismo naukowe
    Wyświetlanie 1-12 z 12

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