Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species.
Autorzy:
Chang XL; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Reed JS; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Webb GM; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Wu HL; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Le J; Quest Clinical Research, San Francisco, California, United States of America. Bateman KB; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Greene JM; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Pessoa C; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Waytashek C; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Weber WC; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Hwang J; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Fischer M; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Moats C; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Shiel O; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Bochart RM; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Crank H; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Siess D; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Giobbi T; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Torgerson J; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Agnor R; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Gao L; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Dhody K; Amarex Clinical Research LLC, Germantown, Maryland, United States of America. Lalezari JP; Quest Clinical Research, San Francisco, California, United States of America. Bandar IS; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, United States of America. Carnate AM; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, United States of America. Pang AS; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, United States of America. Corley MJ; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, United States of America. Kelly S; CytoDyn Inc., Vancouver, Washington, United States of America. Pourhassan N; CytoDyn Inc., Vancouver, Washington, United States of America. Smedley J; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Bimber BN; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America. Hansen SG; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America. Ndhlovu LC; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, United States of America. Sacha JB; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Mar 31; Vol. 18 (3), pp. e1010396. Date of Electronic Publication: 2022 Mar 31 (Print Publication: 2022).
Barrenäs F; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. Hansen SG; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Law L; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, United States of America. Driscoll C; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, United States of America. Green RR; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, United States of America. Smith E; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, United States of America. Chang J; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, United States of America. Golez I; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, United States of America. Urion T; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, United States of America. Peng X; Department of Molecular Biomedical Sciences and Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America. Whitmore L; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, United States of America. Newhouse D; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, United States of America. Hughes CM; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Morrow D; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Randall KT; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Selseth AN; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Ford JC; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Gilbride RM; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Randall BE; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Ainslie E; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Oswald K; AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America. Shoemaker R; AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America. Fast R; AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America. Bosche WJ; AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America. Axthelm MK; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Fukazawa Y; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Pavlakis GN; Human Retrovirus Section, Vaccine Branch, National Cancer Institute at Frederick, Frederick, Maryland, United States of America. Felber BK; Human Retrovirus Pathogenesis Section, Vaccine Branch, National Cancer Institute at Frederick, Frederick, Maryland, United States of America. Fourati S; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America. Sekaly RP; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America. Lifson JD; AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Leidos Biomedical Research, Inc., Frederick, Maryland, United States of America. Komorowski J; Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden. Kosmider E; Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America. Shao D; Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America. Song W; Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America. Edlefsen PT; Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America. Picker LJ; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America. Gale M Jr; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, Washington, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 Jul 06; Vol. 17 (7), pp. e1009278. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques.
Autorzy:
Bochart RM; Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Busman-Sahay K; Division of Pathobiology and Immunology, Oregon National Primate Research Center, and Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Bondoc S; Division of Pathobiology and Immunology, Oregon National Primate Research Center, and Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Morrow DW; Division of Pathobiology and Immunology, Oregon National Primate Research Center, and Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Ortiz AM; Barrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United State of America. Fennessey CM; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America. Fischer MB; Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Shiel O; Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Swanson T; Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Shriver-Munsch CM; Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Crank HB; Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Armantrout KM; Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Barber-Axthelm AM; Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Langner C; Barrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United State of America. Moats CR; Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Labriola CS; Division of Pathobiology and Immunology, Oregon National Primate Research Center, and Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. MacAllister R; Division of Comparative Medicine, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America. Axthelm MK; Division of Pathobiology and Immunology, Oregon National Primate Research Center, and Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Brenchley JM; Barrier Immunity Section, Lab of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United State of America. Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America. Estes JD; Division of Pathobiology and Immunology, Oregon National Primate Research Center, and Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Hansen SG; Division of Pathobiology and Immunology, Oregon National Primate Research Center, and Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America. Smedley JV; Infectious Disease Resource, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Division of Pathobiology and Immunology, Oregon National Primate Research Center, and Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2021 May 10; Vol. 17 (5), pp. e1009565. Date of Electronic Publication: 2021 May 10 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Modulation of MHC-E transport by viral decoy ligands is required for RhCMV/SIV vaccine efficacy.
Autorzy:
Verweij MC; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Hansen SG; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Iyer R; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. John N; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Malouli D; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Morrow D; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Scholz I; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Womack J; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Abdulhaqq S; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Gilbride RM; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Hughes CM; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Ventura AB; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Ford JC; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Selseth AN; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Oswald K; AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD 21702, USA. Shoemaker R; AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD 21702, USA. Berkemeier B; AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD 21702, USA. Bosche WJ; AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD 21702, USA. Hull M; AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD 21702, USA. Shao J; Population Sciences and Computational Biology Programs, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Sacha JB; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Axthelm MK; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. Edlefsen PT; Population Sciences and Computational Biology Programs, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD 21702, USA. Picker LJ; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. . Früh K; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2021 Apr 30; Vol. 372 (6541). Date of Electronic Publication: 2021 Mar 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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