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Tytuł :
In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome.
Autorzy :
Taher H; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Mahyari E; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Kreklywich C; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Uebelhoer LS; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
McArdle MR; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Moström MJ; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, United States of America.
Bhusari A; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Nekorchuk M; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
E X; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
Whitmer T; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Scheef EA; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, United States of America.
Sprehe LM; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, United States of America.
Roberts DL; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Hughes CM; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Jackson KA; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Selseth AN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Ventura AB; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Cleveland-Rubeor HC; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Yue Y; Center for Comparative Medicine and Department of Medical Pathology, University of California, Davis, California, United States of America.
Schmidt KA; Center for Comparative Medicine and Department of Medical Pathology, University of California, Davis, California, United States of America.
Shao J; Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Edlefsen PT; Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Smedley J; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Kowalik TF; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
Stanton RJ; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Axthelm MK; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Estes JD; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Hansen SG; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Kaur A; Tulane National Primate Research Center, Tulane University, Covington, Louisiana, United States of America.
Barry PA; Center for Comparative Medicine and Department of Medical Pathology, University of California, Davis, California, United States of America.
Bimber BN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Picker LJ; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Streblow DN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Früh K; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Malouli D; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Nov 24; Vol. 16 (11), pp. e1008666. Date of Electronic Publication: 2020 Nov 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Viremia*
Cytomegalovirus/*genetics
Cytomegalovirus Infections/*virology
Genome, Viral/*genetics
Animals ; Cell Line ; Chromosomes, Artificial, Bacterial ; Cytomegalovirus/pathogenicity ; DNA, Recombinant ; Disease Models, Animal ; Female ; Fibroblasts/virology ; Humans ; Macaca mulatta ; Male ; Mutation ; Open Reading Frames/genetics ; Phylogeny ; Species Specificity
Czasopismo naukowe
Tytuł :
Characterization of a live-attenuated HCMV-based vaccine platform.
Autorzy :
Caposio P; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
van den Worm S; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.; Batavia Biosciences B.V., Zernikedreef 16, 2333 CL, Leiden, Netherlands.
Crawford L; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Perez W; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Kreklywich C; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Gilbride RM; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Hughes CM; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Ventura AB; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Ratts R; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.; Vir Biotechnology, 4640, SW Macadam Avenue, Portland, OR, 97239, USA.
Marshall EE; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.; Vir Biotechnology, 4640, SW Macadam Avenue, Portland, OR, 97239, USA.
Malouli D; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Axthelm MK; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Streblow D; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Nelson JA; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Picker LJ; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA.
Hansen SG; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA. .
Früh K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, 97006, USA. .
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Źródło :
Scientific reports [Sci Rep] 2019 Dec 17; Vol. 9 (1), pp. 19236. Date of Electronic Publication: 2019 Dec 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytomegalovirus*/genetics
Cytomegalovirus*/immunology
Cytomegalovirus Infections*/genetics
Cytomegalovirus Infections*/immunology
Cytomegalovirus Infections*/prevention & control
Cytomegalovirus Vaccines*/genetics
Cytomegalovirus Vaccines*/immunology
Animals ; Cell Line, Tumor ; Human Umbilical Vein Endothelial Cells ; Humans ; Mice ; Mice, Inbred NOD ; Vaccines, Attenuated/genetics ; Vaccines, Attenuated/immunology
Czasopismo naukowe
Tytuł :
A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge.
Autorzy :
Hansen SG; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Marshall EE; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Malouli D; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Ventura AB; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Hughes CM; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Ainslie E; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Ford JC; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Morrow D; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Gilbride RM; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Bae JY; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Legasse AW; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Oswald K; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Shoemaker R; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Berkemeier B; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Bosche WJ; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Hull M; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Womack J; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Shao J; Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Edlefsen PT; Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Reed JS; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Burwitz BJ; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Sacha JB; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Axthelm MK; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Früh K; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Picker LJ; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. .
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Źródło :
Science translational medicine [Sci Transl Med] 2019 Jul 17; Vol. 11 (501).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytomegalovirus/*immunology
Cytomegalovirus Vaccines/*immunology
SAIDS Vaccines/*immunology
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Acquired Immunodeficiency Syndrome/*virology
Simian Immunodeficiency Virus/*immunology
Vaccines, Attenuated/*immunology
Animals ; Genetic Vectors/metabolism ; Macaca mulatta ; Necrosis ; T-Lymphocytes/immunology ; Time Factors ; Treatment Outcome ; Vaccination
Czasopismo naukowe
Tytuł :
Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity.
Autorzy :
Marshall EE; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Malouli D; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Hansen SG; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Gilbride RM; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Hughes CM; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Ventura AB; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Ainslie E; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Selseth AN; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Ford JC; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Burke D; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Kreklywich CN; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Womack J; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Legasse AW; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Axthelm MK; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Kahl C; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Streblow D; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Edlefsen PT; Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Picker LJ; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. .
Früh K; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA. .
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Źródło :
Science translational medicine [Sci Transl Med] 2019 Jul 17; Vol. 11 (501).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity*
Cytomegalovirus/*immunology
Cytomegalovirus Vaccines/*immunology
Genetic Vectors/*immunology
Animals ; Co-Repressor Proteins/metabolism ; Cytomegalovirus/growth & development ; Gene Deletion ; Leukocytes/metabolism ; Macaca mulatta ; Proteolysis ; Recombination, Genetic/genetics ; T-Lymphocytes/immunology ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł :
Cytomegalovirus vectors expressing Plasmodium knowlesi antigens induce immune responses that delay parasitemia upon sporozoite challenge.
Autorzy :
Hansen SG; Oregon Health & Science University, Vaccine & Gene Therapy Institute, Beaverton, OR, United States of America.; Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, OR, United States of America.
Womack J; Oregon Health & Science University, Vaccine & Gene Therapy Institute, Beaverton, OR, United States of America.
Scholz I; Oregon Health & Science University, Vaccine & Gene Therapy Institute, Beaverton, OR, United States of America.
Renner A; US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD, United States of America.
Edgel KA; US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD, United States of America.
Xu G; Oregon Health & Science University, Vaccine & Gene Therapy Institute, Beaverton, OR, United States of America.
Ford JC; Oregon Health & Science University, Vaccine & Gene Therapy Institute, Beaverton, OR, United States of America.
Grey M; Oregon Health & Science University, Vaccine & Gene Therapy Institute, Beaverton, OR, United States of America.
St Laurent B; National Institutes of Health, Laboratory of Malaria and Vector Research, Malaria Pathogenesis and Human Immunity Unit, Rockville, MD, United States of America.
Turner JM; Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, OR, United States of America.
Planer S; Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, OR, United States of America.
Legasse AW; Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, OR, United States of America.
Richie TL; US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD, United States of America.
Aguiar JC; US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD, United States of America.
Axthelm MK; Oregon Health & Science University, Vaccine & Gene Therapy Institute, Beaverton, OR, United States of America.; Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, OR, United States of America.
Villasante ED; US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD, United States of America.
Weiss W; US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, MD, United States of America.
Edlefsen PT; Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.
Picker LJ; Oregon Health & Science University, Vaccine & Gene Therapy Institute, Beaverton, OR, United States of America.; Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, OR, United States of America.
Früh K; Oregon Health & Science University, Vaccine & Gene Therapy Institute, Beaverton, OR, United States of America.; Oregon Health & Science University, Oregon National Primate Research Center, Beaverton, OR, United States of America.
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Źródło :
PloS one [PLoS One] 2019 Jan 23; Vol. 14 (1), pp. e0210252. Date of Electronic Publication: 2019 Jan 23 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antigens, Protozoan/*immunology
Cytomegalovirus/*genetics
Malaria/*immunology
Malaria Vaccines/*immunology
Parasitemia/*immunology
Plasmodium knowlesi/*immunology
Sporozoites/*immunology
Animals ; Anopheles/immunology ; Anopheles/parasitology ; Female ; Genetic Vectors/administration & dosage ; Immunologic Memory ; Liver/immunology ; Liver/parasitology ; Macaca mulatta ; Malaria/blood ; Malaria/parasitology ; Malaria/prevention & control ; Male ; Parasitemia/blood ; Parasitemia/parasitology ; Parasitemia/prevention & control ; Plasmodium knowlesi/genetics ; Protozoan Proteins/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/parasitology
Czasopismo naukowe
Tytuł :
Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques.
Autorzy :
Burwitz BJ; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Malouli D; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Bimber BN; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Reed JS; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Ventura AB; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Hancock MH; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Uebelhoer LS; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Bhusari A; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Hammond KB; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Espinosa Trethewy RG; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Klug A; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Legasse AW; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Axthelm MK; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Nelson JA; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Park BS; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Streblow DN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Hansen SG; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Picker LJ; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Früh K; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Sacha JB; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America.; Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2016 Nov 09; Vol. 12 (11), pp. e1006014. Date of Electronic Publication: 2016 Nov 09 (Print Publication: 2016).
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Cytomegalovirus/*genetics
Cytomegalovirus Infections/*transmission
Macaca fascicularis/*virology
Macaca mulatta/*virology
Animals ; Cytomegalovirus Infections/genetics ; DNA, Viral/analysis ; DNA, Viral/genetics ; High-Throughput Nucleotide Sequencing ; Phylogeny ; Species Specificity
Czasopismo naukowe
Tytuł :
Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus.
Autorzy :
Sturgill ER; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Malouli D; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Hansen SG; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Burwitz BJ; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Seo S; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Schneider CL; Department of Life Sciences, Carroll University, Waukesha, Wisconsin, United States of America.
Womack JL; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Verweij MC; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Ventura AB; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Bhusari A; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Jeffries KM; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Legasse AW; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Axthelm MK; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Hudson AW; Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Sacha JB; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Picker LJ; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
Früh K; Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2016 Aug 31; Vol. 12 (8), pp. e1005868. Date of Electronic Publication: 2016 Aug 31 (Print Publication: 2016).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Immune Evasion*
Lymphocyte Activation*
Cytomegalovirus/*immunology
Cytomegalovirus Infections/*immunology
Killer Cells, Natural/*immunology
Animals ; Humans ; K562 Cells ; Macaca fascicularis ; Membrane Glycoproteins/immunology ; NK Cell Lectin-Like Receptor Subfamily K/immunology ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Broadly targeted CD8⁺ T cell responses restricted by major histocompatibility complex E.
Autorzy :
Hansen SG; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Wu HL; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Burwitz BJ; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Hughes CM; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Hammond KB; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Ventura AB; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Reed JS; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Gilbride RM; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Ainslie E; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Morrow DW; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Ford JC; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Selseth AN; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Pathak R; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Malouli D; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Legasse AW; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Axthelm MK; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Nelson JA; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Gillespie GM; Nuffield Department of Medicine, University of Oxford, Oxford OX37FZ, UK.
Walters LC; Nuffield Department of Medicine, University of Oxford, Oxford OX37FZ, UK.
Brackenridge S; Nuffield Department of Medicine, University of Oxford, Oxford OX37FZ, UK.
Sharpe HR; Nuffield Department of Medicine, University of Oxford, Oxford OX37FZ, UK.
López CA; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Früh K; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Korber BT; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. The New Mexico Consortium, Los Alamos, NM 87545, USA.
McMichael AJ; Nuffield Department of Medicine, University of Oxford, Oxford OX37FZ, UK.
Gnanakaran S; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Sacha JB; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Picker LJ; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2016 Feb 12; Vol. 351 (6274), pp. 714-20. Date of Electronic Publication: 2016 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Cytomegalovirus/*immunology
Epitopes, T-Lymphocyte/*immunology
Histocompatibility Antigens Class I/*immunology
Simian Immunodeficiency Virus/*immunology
Animals ; Antigen Presentation ; Antigenic Variation ; Cytomegalovirus/genetics ; Epitopes, T-Lymphocyte/chemistry ; Genetic Vectors/genetics ; Genetic Vectors/immunology ; Histocompatibility Antigens Class I/chemistry ; Host-Pathogen Interactions/immunology ; Immune Evasion ; Killer Cells, Natural/immunology ; Macaca mulatta ; Protein Structure, Secondary ; Vaccination
Czasopismo naukowe
Tytuł :
Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms.
Autorzy :
Hansen SG; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Sacha JB
Hughes CM
Ford JC
Burwitz BJ
Scholz I
Gilbride RM
Lewis MS
Gilliam AN
Ventura AB
Malouli D
Xu G
Richards R
Whizin N
Reed JS
Hammond KB
Fischer M
Turner JM
Legasse AW
Axthelm MK
Edlefsen PT
Nelson JA
Lifson JD
Früh K
Picker LJ
Pokaż więcej
Źródło :
Science (New York, N.Y.) [Science] 2013 May 24; Vol. 340 (6135), pp. 1237874.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Cytomegalovirus/*immunology
Epitopes, T-Lymphocyte/*immunology
Genetic Vectors/*immunology
SAIDS Vaccines/*immunology
Animals ; Cytokines/immunology ; Cytomegalovirus/genetics ; Female ; Genetic Vectors/genetics ; Histocompatibility Antigens Class II/immunology ; Humans ; Macaca mulatta ; Male ; Membrane Glycoproteins/genetics ; SAIDS Vaccines/administration & dosage ; Viral Envelope Proteins/genetics
Czasopismo naukowe
Tytuł :
Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection.
Autorzy :
DeFilippis VR; Oregon Health and Science University, West Campus, Vaccine and Gene Therapy Institute, 505 NW 185th Ave., Beaverton, OR 97006, USA.
Robinson B
Keck TM
Hansen SG
Nelson JA
Früh KJ
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2006 Jan; Vol. 80 (2), pp. 1032-7.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cytomegalovirus/*physiology
Cytomegalovirus Infections/*metabolism
Exonucleases/*metabolism
Interferon Regulatory Factor-3/*metabolism
Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/virology ; Exonucleases/genetics ; Exoribonucleases ; Fibroblasts/metabolism ; Fibroblasts/virology ; Gene Expression Regulation ; Humans ; Immunity, Innate ; Interferon Regulatory Factor-3/genetics
Czasopismo naukowe
Tytuł :
A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism.
Autorzy :
Rue CA; Department of Molecular Microbiology and Immunology, 3181 SW Sam Jackson Road, Oregon Health Sciences University, Portland, OR 97239, USA.
Jarvis MA
Knoche AJ
Meyers HL
DeFilippis VR
Hansen SG
Wagner M
Früh K
Anders DG
Wong SW
Barry PA
Nelson JA
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2004 Nov; Vol. 78 (22), pp. 12529-36.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Cytomegalovirus/*enzymology
Endothelial Cells/*virology
Isoenzymes/*physiology
Macaca mulatta/*virology
Prostaglandin-Endoperoxide Synthases/*physiology
Viral Proteins/*physiology
Amino Acid Sequence ; Animals ; Cyclooxygenase 2 ; Cytomegalovirus/genetics ; Isoenzymes/genetics ; Molecular Sequence Data ; Prostaglandin-Endoperoxide Synthases/genetics ; Tropism ; Virus Replication
Czasopismo naukowe
Tytuł :
Complete sequence and genomic analysis of rhesus cytomegalovirus.
Autorzy :
Hansen SG; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon 97006, USA.
Strelow LI
Franchi DC
Anders DG
Wong SW
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2003 Jun; Vol. 77 (12), pp. 6620-36.
Typ publikacji :
Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Genome, Viral*
Sequence Analysis, DNA*
Cytomegalovirus/*genetics
Macaca mulatta/*virology
Animals ; Cells, Cultured ; DNA, Viral/analysis ; Humans ; Molecular Sequence Data ; Open Reading Frames ; Phylogeny ; Viral Proteins/genetics
Czasopismo naukowe
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