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Wyszukujesz frazę ""Happle, C."" wg kryterium: Autor


Tytuł :
"A bad wound may heal, but a bad name can kill"--lessons learned from "hyper-IgM syndrome".
Autorzy :
Hennig C
Happle C
Hansen G
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2011 Dec; Vol. 128 (6), pp. 1380-2; author reply 1382-1383. Date of Electronic Publication: 2011 Sep 08.
Typ publikacji :
Letter
MeSH Terms :
Terminology as Topic*
Delayed Diagnosis/*prevention & control
Diagnostic Errors/*prevention & control
Hyper-IgM Immunodeficiency Syndrome/*diagnosis
Humans
Opinia redakcyjna
Tytuł :
Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis.
Autorzy :
Lachmann N; 1 Reprogramming and Gene Therapy Group, REBIRTH Cluster of Excellence.
Happle C
Ackermann M
Lüttge D
Wetzke M
Merkert S
Hetzel M
Kensah G
Jara-Avaca M
Mucci A
Skuljec J
Dittrich AM
Pfaff N
Brennig S
Schambach A
Steinemann D
Göhring G
Cantz T
Martin U
Schwerk N
Hansen G
Moritz T
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Źródło :
American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2014 Jan 15; Vol. 189 (2), pp. 167-82.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Therapy*
Induced Pluripotent Stem Cells*
Genetic Diseases, X-Linked/*therapy
Pulmonary Alveolar Proteinosis/*therapy
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/*deficiency
Cell Culture Techniques ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Child, Preschool ; Female ; Genetic Diseases, X-Linked/genetics ; Genetic Diseases, X-Linked/metabolism ; Humans ; Macrophages, Alveolar/metabolism ; Models, Biological ; Monocytes/metabolism ; Pulmonary Alveolar Proteinosis/genetics ; Pulmonary Alveolar Proteinosis/metabolism ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use ; Signal Transduction/drug effects ; Signal Transduction/genetics
SCR Disease Name :
Surfactant Metabolism Dysfunction, Pulmonary, 4
Czasopismo naukowe
Tytuł :
Promoter and lineage independent anti-silencing activity of the A2 ubiquitous chromatin opening element for optimized human pluripotent stem cell-based gene therapy.
Autorzy :
Ackermann M; Reprogramming and Gene Therapy Group, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Lower Saxony 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Lachmann N; Reprogramming and Gene Therapy Group, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Lower Saxony 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Hartung S; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Eggenschwiler R; Translational Hepatology and Stem Cell Biology, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Pfaff N; Reprogramming and Gene Therapy Group, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Lower Saxony 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Happle C; Department of Pediatrics, Hannover Medical School, Hannover, Lower Saxony 30625, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the Center for Lung Research (DZL), Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Mucci A; Reprogramming and Gene Therapy Group, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Göhring G; Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Niemann H; Institute of Farm Animal Genetics, Friedrich-Löffler-Institut, Mariensee/Neustadt, Lower Saxony 31535, Germany.
Hansen G; Department of Pediatrics, Hannover Medical School, Hannover, Lower Saxony 30625, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the Center for Lung Research (DZL), Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Lower Saxony 30625, Germany; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cantz T; Translational Hepatology and Stem Cell Biology, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Zweigerdt R; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Lower Saxony 30625, Germany.
Moritz T; Reprogramming and Gene Therapy Group, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Lower Saxony 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover, Lower Saxony 30625, Germany. Electronic address: .
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Źródło :
Biomaterials [Biomaterials] 2014 Feb; Vol. 35 (5), pp. 1531-42. Date of Electronic Publication: 2013 Nov 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Silencing*
Genetic Therapy*
Promoter Regions, Genetic*
Chromatin/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Animals ; Cell Differentiation ; Cell Lineage ; HEK293 Cells ; Humans ; Induced Pluripotent Stem Cells/cytology ; Mice ; Reverse Transcriptase Polymerase Chain Reaction ; Transgenes
Czasopismo naukowe
Tytuł :
Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis.
Autorzy :
Happle C; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany. Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany.
Lachmann N; Reprogramming and Gene Therapy Group, REBIRTH Cluster-of Excellence, Hannover Medical School, 30625 Hannover, Germany. Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Škuljec J; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.
Wetzke M; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.
Ackermann M; Reprogramming and Gene Therapy Group, REBIRTH Cluster-of Excellence, Hannover Medical School, 30625 Hannover, Germany. Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Brennig S; Reprogramming and Gene Therapy Group, REBIRTH Cluster-of Excellence, Hannover Medical School, 30625 Hannover, Germany. Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Mucci A; Reprogramming and Gene Therapy Group, REBIRTH Cluster-of Excellence, Hannover Medical School, 30625 Hannover, Germany. Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Jirmo AC; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany. Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany.
Groos S; Institute of Cell Biology in the Center of Anatomy, Hannover Medical School, 30625 Hannover, Germany.
Mirenska A; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.
Hennig C; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany. Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany.
Rodt T; Department of Diagnostic and Interventional Radiology, Hannover Medical School, 30625 Hannover, Germany.
Bankstahl JP; Institute for Preclinical Molecular Imaging, Hannover Medical School, 30625 Hannover, Germany.
Schwerk N; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany. Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany.
Moritz T; Reprogramming and Gene Therapy Group, REBIRTH Cluster-of Excellence, Hannover Medical School, 30625 Hannover, Germany. Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Hansen G; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany. Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany. .
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Źródło :
Science translational medicine [Sci Transl Med] 2014 Aug 20; Vol. 6 (250), pp. 250ra113.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lung Transplantation*
Stem Cell Transplantation*
Macrophages/*transplantation
Pulmonary Alveolar Proteinosis/*therapy
Animals ; Cell Differentiation ; Child, Preschool ; Cytokine Receptor Common beta Subunit/deficiency ; Cytokine Receptor Common beta Subunit/metabolism ; Humans ; Mice ; Phenotype ; Pulmonary Alveolar Proteinosis/pathology ; Time Factors
Czasopismo naukowe
Tytuł :
Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies.
Autorzy :
Lachmann N; RG Reprogramming and Gene Therapy, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover 30625, Germany.
Ackermann M; RG Reprogramming and Gene Therapy, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover 30625, Germany.
Frenzel E; Department of Respiratory Medicine, Hannover Medical School, Hannover 30625, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover 30625, Germany.
Liebhaber S; RG Reprogramming and Gene Therapy, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover 30625, Germany.
Brennig S; RG Reprogramming and Gene Therapy, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover 30625, Germany.
Happle C; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover 30625, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover 30625, Germany.
Hoffmann D; Institute of Experimental Hematology, Hannover Medical School, Hannover 30625, Germany.
Klimenkova O; Department of Molecular Hematopoiesis, Hannover Medical School, Hannover 30625, Germany.
Lüttge D; RG Reprogramming and Gene Therapy, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover 30625, Germany.
Buchegger T; RG Reprogramming and Gene Therapy, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover 30625, Germany.
Kühnel MP; Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover 30625, Germany.
Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover 30625, Germany; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Janciauskiene S; Department of Respiratory Medicine, Hannover Medical School, Hannover 30625, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover 30625, Germany.
Figueiredo C; Institute for Transfusion Medicine, Hannover Medical School, Hannover 30625, Germany.
Hansen G; Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover 30625, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover 30625, Germany.
Skokowa J; Department of Molecular Hematopoiesis, Hannover Medical School, Hannover 30625, Germany.
Moritz T; RG Reprogramming and Gene Therapy, REBIRTH Cluster of Excellence, Hannover Medical School, Hannover 30625, Germany; Institute of Experimental Hematology, Hannover Medical School, Hannover 30625, Germany. Electronic address: .
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Źródło :
Stem cell reports [Stem Cell Reports] 2015 Feb 10; Vol. 4 (2), pp. 282-96.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Culture Techniques*
Cell Differentiation*/drug effects
Granulocytes/*cytology
Induced Pluripotent Stem Cells/*cytology
Macrophages/*cytology
Cell- and Tissue-Based Therapy/methods ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Granulocytes/metabolism ; Humans ; Immunohistochemistry ; Immunophenotyping ; Induced Pluripotent Stem Cells/drug effects ; Induced Pluripotent Stem Cells/metabolism ; Interleukin-3/pharmacology ; Macrophages/metabolism ; Phenotype
Czasopismo naukowe
Tytuł :
Neutrophilic superoxide production can assess pharmacological and pharmacogenetic β-adrenoreceptor effects.
Autorzy :
Reinartz MT; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Wetzke M; Department for Paediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany.
Happle C; Department for Paediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany.; Member of German Lung Research Centre (DZL).
Kälble S; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
Scherer R; Institute for Biometry, Hannover Medical School, Hannover, Germany.
Kabesch M; Department for Paediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany.; Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg, Regensburg, Germany.; Member of German Lung Research Centre (DZL).
Seifert R; Institute of Pharmacology, Hannover Medical School, Hannover, Germany.
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Źródło :
Allergy [Allergy] 2016 Aug; Vol. 71 (8), pp. 1223-7. Date of Electronic Publication: 2016 May 30.
Typ publikacji :
Journal Article
MeSH Terms :
Pharmacogenomic Variants*
Adrenergic beta-Agonists/*therapeutic use
Neutrophils/*metabolism
Superoxides/*metabolism
Adrenergic beta-Agonists/pharmacology ; Alleles ; Asthma/drug therapy ; Asthma/genetics ; Asthma/immunology ; Biomarkers ; Female ; Genotype ; Humans ; Male ; Neutrophils/drug effects ; Neutrophils/immunology ; Polymorphism, Single Nucleotide ; Reactive Oxygen Species/metabolism ; Receptors, Adrenergic, beta-2/genetics ; Receptors, Adrenergic, beta-2/metabolism ; Treatment Outcome
Czasopismo naukowe

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