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Tytuł:
Cognitive Remediation in Bipolar (CRiB2): study protocol for a randomised controlled trial assessing efficacy and mechanisms of cognitive remediation therapy compared to treatment as usual.
Autorzy:
Tsapekos D; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 103 Denmark Hill, London, SE5 8AZ, UK. .
Strawbridge R; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 103 Denmark Hill, London, SE5 8AZ, UK.
Cella M; Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK.
Goldsmith K; Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Kalfas M; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 103 Denmark Hill, London, SE5 8AZ, UK.
Taylor RH; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 103 Denmark Hill, London, SE5 8AZ, UK.
Swidzinski S; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 103 Denmark Hill, London, SE5 8AZ, UK.
Marwaha S; Institute for Mental Health, University of Birmingham, Edgbaston, Birmingham, UK.
Grey L; Institute for Mental Health, University of Birmingham, Edgbaston, Birmingham, UK.
Newton E; Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK.
Shackleton J; Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK.
Harrison PJ; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK.
Browning M; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK.
Harmer C; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK.
Hartland H; Department of Psychiatry, University of Oxford, Oxford, UK.
Cousins D; Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, UK.; Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle Upon Tyne, UK.
Barton S; Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust, Newcastle Upon Tyne, UK.
Wykes T; Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.; South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK.
Young AH; Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 103 Denmark Hill, London, SE5 8AZ, UK.; South London and Maudsley NHS Foundation Trust, Bethlem Royal Hospital, Beckenham, UK.
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Źródło:
BMC psychiatry [BMC Psychiatry] 2023 Nov 15; Vol. 23 (1), pp. 842. Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:
Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bipolar Disorder*/therapy
Bipolar Disorder*/psychology
Cognitive Remediation*
Cognitive Behavioral Therapy*/methods
Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Aged ; Affect ; Cognition ; Treatment Outcome ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluating the utility of brightfield image data for mechanism of action prediction.
Autorzy:
Harrison PJ; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.; Science for Life Laboratory, Uppsala, Sweden.
Gupta A; Department of Information Technology, Uppsala University, Uppsala, Sweden.
Rietdijk J; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.; Science for Life Laboratory, Uppsala, Sweden.
Wieslander H; Department of Information Technology, Uppsala University, Uppsala, Sweden.
Carreras-Puigvert J; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.; Science for Life Laboratory, Uppsala, Sweden.
Georgiev P; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.; Science for Life Laboratory, Uppsala, Sweden.
Wählby C; Science for Life Laboratory, Uppsala, Sweden.; Department of Information Technology, Uppsala University, Uppsala, Sweden.
Spjuth O; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.; Science for Life Laboratory, Uppsala, Sweden.
Sintorn IM; Department of Information Technology, Uppsala University, Uppsala, Sweden.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2023 Jul 25; Vol. 19 (7), pp. e1011323. Date of Electronic Publication: 2023 Jul 25 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Image Processing, Computer-Assisted*/methods
Microscopy, Fluorescence/methods ; Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pathogen-sugar interactions revealed by universal saturation transfer analysis.
Autorzy:
Buchanan CJ; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.; Kavli Institute of Nanoscience Discovery, University of Oxford, Oxford OX1 3QU, UK.
Gaunt B; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.
Harrison PJ; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.; Diamond Light Source, Harwell Science and Innovation Campus, Oxfordshire, UK.
Yang Y; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.
Liu J; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.
Khan A; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.
Giltrap AM; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.
Le Bas A; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.
Ward PN; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.
Gupta K; Max Planck Bristol Centre for Minimal Biology, University of Bristol, Bristol, UK.
Dumoux M; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.
Tan TK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Schimaski L; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Daga S; Medical Genetics, University of Siena, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Picchiotti N; Department of Information Engineering and Mathematics, University of Siena, Siena, Italy.; Department of Mathematics, University of Pavia, Pavia, Italy.
Baldassarri M; Medical Genetics, University of Siena, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Benetti E; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Fallerini C; Medical Genetics, University of Siena, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Fava F; Medical Genetics, University of Siena, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Giliberti A; Medical Genetics, University of Siena, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Koukos PI; Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, Netherlands.
Davy MJ; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.
Lakshminarayanan A; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.
Xue X; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.; Sir William Dunn School of Pathology, Oxford, UK.
Papadakis G; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.
Deimel LP; Sir William Dunn School of Pathology, Oxford, UK.
Casablancas-Antràs V; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.; Kavli Institute of Nanoscience Discovery, University of Oxford, Oxford OX1 3QU, UK.
Claridge TDW; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.
Bonvin AMJJ; Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, Netherlands.
Sattentau QJ; Sir William Dunn School of Pathology, Oxford, UK.
Furini S; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Gori M; Department of Information Engineering and Mathematics, University of Siena, Siena, Italy.; Maasai, I3S CNRS, Université Côte d'Azur, Nice, France.
Huo J; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.
Owens RJ; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.
Schaffitzel C; Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, Netherlands.
Berger I; Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, Netherlands.
Renieri A; Medical Genetics, University of Siena, Siena, Italy.; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Naismith JH; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK.
Baldwin AJ; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.; Kavli Institute of Nanoscience Discovery, University of Oxford, Oxford OX1 3QU, UK.
Davis BG; Rosalind Franklin Institute, Harwell Science and Innovation Campus, Oxford OX11 0FA, UK.; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.; Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
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Corporate Authors:
GEN-COVID Multicenter Study
Źródło:
Science (New York, N.Y.) [Science] 2022 Jul 22; Vol. 377 (6604), pp. eabm3125. Date of Electronic Publication: 2022 Jul 22.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*/transmission
Host-Pathogen Interactions*
SARS-CoV-2*/chemistry
SARS-CoV-2*/genetics
Sialic Acids*/chemistry
Spike Glycoprotein, Coronavirus*/chemistry
Spike Glycoprotein, Coronavirus*/genetics
Cryoelectron Microscopy ; Genetic Variation ; Humans ; Nuclear Magnetic Resonance, Biomolecular ; Polysaccharides/chemistry ; Protein Binding ; Protein Domains
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predicting protein network topology clusters from chemical structure using deep learning.
Autorzy:
Sreenivasan AP; Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 75124, Uppsala, Sweden.; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Harrison PJ; Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 75124, Uppsala, Sweden.
Schaal W; Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 75124, Uppsala, Sweden.
Matuszewski DJ; Centre for Image Analysis, Department of Information Technology, Uppsala University, Uppsala, Sweden.
Kultima K; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Spjuth O; Department of Pharmaceutical Biosciences, Uppsala University, Box 591, 75124, Uppsala, Sweden. .
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Źródło:
Journal of cheminformatics [J Cheminform] 2022 Jul 15; Vol. 14 (1), pp. 47. Date of Electronic Publication: 2022 Jul 15.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Learning to see colours: Biologically relevant virtual staining for adipocyte cell images.
Autorzy:
Wieslander H; Department of Information Technology, Uppsala University, Uppsala, Sweden.
Gupta A; Department of Information Technology, Uppsala University, Uppsala, Sweden.
Bergman E; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Hallström E; Department of Information Technology, Uppsala University, Uppsala, Sweden.
Harrison PJ; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
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Źródło:
PloS one [PLoS One] 2021 Oct 15; Vol. 16 (10), pp. e0258546. Date of Electronic Publication: 2021 Oct 15 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adipocytes/*pathology
Microscopy, Fluorescence/*methods
Cell Nucleus/pathology ; Cytoplasm/pathology ; Humans ; Image Processing, Computer-Assisted ; Models, Biological ; Staining and Labeling
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19.
Autorzy:
Taquet M; Department of Psychiatry, University of Oxford, United Kingdom.; Oxford Health NHS Foundation Trust, Oxford, United Kingdom.
Dercon Q; Department of Psychiatry, University of Oxford, United Kingdom.
Luciano S; TriNetX Inc., Cambridge, Massachusetts, United States of America.
Geddes JR; Department of Psychiatry, University of Oxford, United Kingdom.; Oxford Health NHS Foundation Trust, Oxford, United Kingdom.
Husain M; Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Harrison PJ; Department of Psychiatry, University of Oxford, United Kingdom.; Oxford Health NHS Foundation Trust, Oxford, United Kingdom.
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Źródło:
PLoS medicine [PLoS Med] 2021 Sep 28; Vol. 18 (9), pp. e1003773. Date of Electronic Publication: 2021 Sep 28 (Print Publication: 2021).
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Survivors*
COVID-19/*complications
Adult ; Aged ; COVID-19/epidemiology ; Cohort Studies ; Dyspnea/epidemiology ; Dyspnea/etiology ; Fatigue/epidemiology ; Fatigue/etiology ; Female ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/etiology ; Humans ; Incidence ; Influenza, Human/complications ; Influenza, Human/epidemiology ; Male ; Mental Disorders/epidemiology ; Mental Disorders/etiology ; Middle Aged ; Pain/epidemiology ; Pain/etiology ; Proportional Hazards Models ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; United States/epidemiology ; Young Adult ; Post-Acute COVID-19 Syndrome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Incidence of Parkinson's disease, dementia, cerebrovascular disease and stroke in bipolar disorder compared to other psychiatric disorders: An electronic health records network study of 66 million people.
Autorzy:
Harrison PJ; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK.
Luciano S; TriNetX Inc, Cambridge, MA, USA.
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Źródło:
Bipolar disorders [Bipolar Disord] 2021 Aug; Vol. 23 (5), pp. 454-462. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bipolar Disorder*/epidemiology
Dementia*/epidemiology
Depressive Disorder, Major*
Parkinson Disease*/epidemiology
Stroke*/epidemiology
Adult ; Electronic Health Records ; Humans ; Incidence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rapid development of cloud-native intelligent data pipelines for scientific data streams using the HASTE Toolkit.
Autorzy:
Blamey B; Department of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.
Toor S; Department of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.
Dahlö M; Department of Pharmaceutical Biosciences, Uppsala University, Husargatan 3, 75237, Uppsala, Sweden.; Science for Life Laboratory, Uppsala University, Husargatan 3, 75237 Uppsala, Sweden.
Wieslander H; Department of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.
Harrison PJ; Department of Pharmaceutical Biosciences, Uppsala University, Husargatan 3, 75237, Uppsala, Sweden.; Science for Life Laboratory, Uppsala University, Husargatan 3, 75237 Uppsala, Sweden.
Sintorn IM; Department of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.; Science for Life Laboratory, Uppsala University, Husargatan 3, 75237 Uppsala, Sweden.; Vironova AB, Gävlegatan 22, 11330 Stockholm, Sweden.
Sabirsh A; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Wählby C; Department of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.; Science for Life Laboratory, Uppsala University, Husargatan 3, 75237 Uppsala, Sweden.
Spjuth O; Department of Pharmaceutical Biosciences, Uppsala University, Husargatan 3, 75237, Uppsala, Sweden.; Science for Life Laboratory, Uppsala University, Husargatan 3, 75237 Uppsala, Sweden.
Hellander A; Department of Information Technology, Uppsala University, Lägerhyddsvägen 2, 75237 Uppsala, Sweden.
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Źródło:
GigaScience [Gigascience] 2021 Mar 19; Vol. 10 (3).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biological Science Disciplines*
Software*
Diagnostic Imaging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study.
Autorzy:
Atkinson LZ; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK.; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Warneford Hospital, Oxford, UK.
Colbourne L; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK.; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Warneford Hospital, Oxford, UK.
Smith A; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK.
Harmer CH; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK.; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Warneford Hospital, Oxford, UK.
Nobre AC; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Warneford Hospital, Oxford, UK.; Department of Experimental Psychology, University of Oxford, New Radcliffe House, Oxford, UK.
Rendell J; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK.
Jones H; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK.
Hinds C; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Big Data Institute, University of Oxford, Old Road Campus, Oxford, UK.
Mould A; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK.
Tunbridge EM; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK.
Cipriani A; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK.
Geddes JR; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK.
Saunders KEA; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK. .; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK. .
Harrison PJ; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK. paul.harrison@psych.ox.ac.uk.; Oxford Health Foundation NHS Trust, Warneford Hospital, Oxford, UK. paul.harrison@psych.ox.ac.uk.; Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, Warneford Hospital, Oxford, UK. paul.harrison@psych.ox.ac.uk.
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Źródło:
Trials [Trials] 2019 Feb 12; Vol. 20 (1), pp. 120. Date of Electronic Publication: 2019 Feb 12.
Typ publikacji:
Clinical Trial Protocol; Journal Article
MeSH Terms:
Randomized Controlled Trials as Topic*
Calcium Channel Blockers/*therapeutic use
Cognition/*drug effects
Mood Disorders/*drug therapy
Nicardipine/*therapeutic use
Sleep/*drug effects
Adolescent ; Adult ; Calcium Channel Blockers/pharmacology ; Calcium Channels, L-Type/genetics ; Double-Blind Method ; Humans ; Magnetic Resonance Imaging ; Magnetoencephalography ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biochemical and genetic predictors and correlates of response to lamotrigine and folic acid in bipolar depression: Analysis of the CEQUEL clinical trial.
Autorzy:
Tunbridge EM; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK.; National Institute for Health Research (NIHR) Oxford Health Biomedical Research Centre, Oxford, UK.
Attenburrow MJ; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK.
Gardiner A; NIHR CLAHRC Oxford, Oxford Health NHS Foundation Trust, Oxford, UK.; Department of Primary Care, University of Oxford, Oxford, UK.
Rendell JM; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK.
Hinds C; Oxford University Big Data Institute, University of Oxford, Oxford, UK.
Goodwin GM; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK.
Harrison PJ; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK.; National Institute for Health Research (NIHR) Oxford Health Biomedical Research Centre, Oxford, UK.
Geddes JR; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Foundation Trust, Oxford, UK.; National Institute for Health Research (NIHR) Oxford Health Biomedical Research Centre, Oxford, UK.
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Źródło:
Bipolar disorders [Bipolar Disord] 2017 Sep; Vol. 19 (6), pp. 477-486. Date of Electronic Publication: 2017 Aug 20.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Bipolar Disorder*/diagnosis
Bipolar Disorder*/drug therapy
Bipolar Disorder*/genetics
Folic Acid*/administration & dosage
Folic Acid*/pharmacokinetics
Quetiapine Fumarate*/administration & dosage
Quetiapine Fumarate*/pharmacokinetics
Triazines*/administration & dosage
Triazines*/pharmacokinetics
Catechol O-Methyltransferase/*genetics
Adult ; Brief Psychiatric Rating Scale ; Double-Blind Method ; Drug Combinations ; Female ; Humans ; Lamotrigine ; Male ; Pharmacogenomic Testing ; Psychotropic Drugs/administration & dosage ; Psychotropic Drugs/pharmacokinetics ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice.
Autorzy:
Boerner T; Department of Experimental Psychology, University of Oxford, 9 South Parks, Oxford, OX1 3UD, UK.
Bygrave AM; Department of Experimental Psychology, University of Oxford, 9 South Parks, Oxford, OX1 3UD, UK.
Chen J; Department of Experimental Psychology, University of Oxford, 9 South Parks, Oxford, OX1 3UD, UK.
Fernando A; Department of Experimental Psychology, University of Oxford, 9 South Parks, Oxford, OX1 3UD, UK.
Jackson S; Department of Experimental Psychology, University of Oxford, 9 South Parks, Oxford, OX1 3UD, UK.
Barkus C; Department of Experimental Psychology, University of Oxford, 9 South Parks, Oxford, OX1 3UD, UK.
Sprengel R; Max Planck Research Group, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
Seeburg PH; Max Planck Research Group, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
Harrison PJ; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Gilmour G; Lilly Centre for Cognitive Neuroscience, Discovery Biology, Lilly Research Centre, Lilly UK, Windlesham, Surrey, UK.
Bannerman DM; Department of Experimental Psychology, University of Oxford, 9 South Parks, Oxford, OX1 3UD, UK.
Sanderson DJ; Department of Psychology, Durham University, Science Site, South Road, Durham, DH1 3LE, UK.
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2017 Apr; Vol. 45 (7), pp. 912-921. Date of Electronic Publication: 2017 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
Bridged Bicyclo Compounds/*pharmacology
Dopamine Antagonists/*pharmacology
Excitatory Amino Acid Agonists/*pharmacology
Haloperidol/*pharmacology
Hyperkinesis/*metabolism
Memory, Short-Term/*drug effects
Receptors, AMPA/*genetics
Animals ; Bridged Bicyclo Compounds/therapeutic use ; Dopamine Antagonists/therapeutic use ; Excitatory Amino Acid Agonists/therapeutic use ; Female ; Haloperidol/therapeutic use ; Hyperkinesis/drug therapy ; Hyperkinesis/physiopathology ; Locomotion/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, AMPA/antagonists & inhibitors ; Receptors, AMPA/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Searching for cognitive enhancement in the Morris water maze: better and worse performance in D-amino acid oxidase knockout (Dao(-/-)) mice.
Autorzy:
Pritchett D; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), John Radcliffe Hospital, University of Oxford, Oxford, UK.
Taylor AM; Department of Experimental Psychology, University of Oxford, Tinbergen Building, 9 South Parks Road, Oxford, OX1 3UD, UK.
Barkus C; Department of Pharmacology, University of Oxford, Oxford, UK.
Engle SJ; Pfizer Inc., Groton, CT, USA.
Brandon NJ; Pfizer Inc., Groton, CT, USA.
Sharp T; Department of Pharmacology, University of Oxford, Oxford, UK.
Foster RG; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), John Radcliffe Hospital, University of Oxford, Oxford, UK.
Harrison PJ; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Peirson SN; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), John Radcliffe Hospital, University of Oxford, Oxford, UK.
Bannerman DM; Department of Experimental Psychology, University of Oxford, Tinbergen Building, 9 South Parks Road, Oxford, OX1 3UD, UK.
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Źródło:
The European journal of neuroscience [Eur J Neurosci] 2016 Apr; Vol. 43 (7), pp. 979-89. Date of Electronic Publication: 2016 Mar 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cognition*
Maze Learning*
D-Amino-Acid Oxidase/*genetics
Animals ; D-Amino-Acid Oxidase/metabolism ; Female ; Male ; Memory, Long-Term ; Mice ; Spatial Memory
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial.
Autorzy:
Saunders KE; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. .
Cipriani A; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. .
Rendell J; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. .
Attenburrow MJ; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. .
Nelissen N; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. .
Bilderbeck AC; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. .
Vasudevan SR; Department of Pharmacology, Oxford University, Mansfield Road, Oxford, OX1 3QT, United Kingdom. .
Churchill G; Department of Pharmacology, Oxford University, Mansfield Road, Oxford, OX1 3QT, United Kingdom. .
Goodwin GM; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. .
Nobre AC; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. .
Harmer CJ; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. .
Harrison PJ; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. paul.harrison@psych.ox.ac.uk.
Geddes JR; Department of Psychiatry, Oxford University, Oxford Health NHS Foundation Trust , Warneford Hospital, Oxford, OX3 7JX, United Kingdom. .
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Źródło:
Trials [Trials] 2016 Mar 02; Vol. 17 (1), pp. 116. Date of Electronic Publication: 2016 Mar 02.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Affect/*drug effects
Antimanic Agents/*therapeutic use
Bipolar Disorder/*drug therapy
Brain/*drug effects
Cognition/*drug effects
Lithium Carbonate/*therapeutic use
Adult ; Antimanic Agents/adverse effects ; Biomarkers/blood ; Bipolar Disorder/diagnosis ; Bipolar Disorder/physiopathology ; Bipolar Disorder/psychology ; Brain/metabolism ; Brain/physiopathology ; Clinical Protocols ; Double-Blind Method ; England ; Female ; Gene Expression Regulation/drug effects ; Humans ; Lithium Carbonate/adverse effects ; Magnetic Resonance Imaging ; Magnetoencephalography ; Male ; Neuropsychological Tests ; Prospective Studies ; Psychiatric Status Rating Scales ; Research Design ; Time Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Innovative approaches to bipolar disorder and its treatment.
Autorzy:
Harrison PJ; Department of Psychiatry, University of Oxford, Oxford, United Kingdom.; Oxford Health NHS Foundation Trust, Oxford, United Kingdom.
Cipriani A; Department of Psychiatry, University of Oxford, Oxford, United Kingdom.; Oxford Health NHS Foundation Trust, Oxford, United Kingdom.
Harmer CJ; Department of Psychiatry, University of Oxford, Oxford, United Kingdom.; Oxford Health NHS Foundation Trust, Oxford, United Kingdom.
Nobre AC; Department of Psychiatry, University of Oxford, Oxford, United Kingdom.; Oxford Health NHS Foundation Trust, Oxford, United Kingdom.; Oxford Centre for Human Brain Activity, Warneford Hospital, Oxford, United Kingdom.
Saunders K; Department of Psychiatry, University of Oxford, Oxford, United Kingdom.; Oxford Health NHS Foundation Trust, Oxford, United Kingdom.
Goodwin GM; Department of Psychiatry, University of Oxford, Oxford, United Kingdom.; Oxford Health NHS Foundation Trust, Oxford, United Kingdom.
Geddes JR; Department of Psychiatry, University of Oxford, Oxford, United Kingdom.; Oxford Health NHS Foundation Trust, Oxford, United Kingdom.
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Źródło:
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2016 Feb; Vol. 1366 (1), pp. 76-89.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Antidepressive Agents/*therapeutic use
Antipsychotic Agents/*therapeutic use
Bipolar Disorder/*drug therapy
Bipolar Disorder/*genetics
Genome-Wide Association Study/*methods
Animals ; Bipolar Disorder/diagnosis ; Genome-Wide Association Study/trends ; Humans ; Therapies, Investigational/methods ; Therapies, Investigational/trends ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biochemical characterization and selective inhibition of β-carotene cis-trans isomerase D27 and carotenoid cleavage dioxygenase CCD8 on the strigolactone biosynthetic pathway.
Autorzy:
Harrison PJ; Department of Chemistry, University of Warwick, Coventry, UK.
Newgas SA; Department of Chemistry, University of Warwick, Coventry, UK.
Descombes F; Department of Chemistry, University of Warwick, Coventry, UK.
Shepherd SA; Department of Chemistry, University of Warwick, Coventry, UK.
Thompson AJ; Cranfield Soil and Agrifood Institute, Cranfield University, Cranfield, UK.
Bugg TD; Department of Chemistry, University of Warwick, Coventry, UK.
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Źródło:
The FEBS journal [FEBS J] 2015 Oct; Vol. 282 (20), pp. 3986-4000. Date of Electronic Publication: 2015 Aug 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Design*
Arabidopsis Proteins/*antagonists & inhibitors
Dioxygenases/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Plant Growth Regulators/*pharmacology
Plant Proteins/*antagonists & inhibitors
cis-trans-Isomerases/*antagonists & inhibitors
Acetates/chemistry ; Acetates/pharmacology ; Arabidopsis/enzymology ; Arabidopsis Proteins/chemistry ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Biocatalysis ; Carotenoids/chemistry ; Carotenoids/metabolism ; Dioxygenases/chemistry ; Dioxygenases/genetics ; Dioxygenases/metabolism ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Hydrogen-Ion Concentration ; Hydroxamic Acids/chemical synthesis ; Hydroxamic Acids/chemistry ; Hydroxamic Acids/pharmacology ; Molecular Structure ; Oryza/enzymology ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Plant Growth Regulators/chemical synthesis ; Plant Growth Regulators/chemistry ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Silver Compounds/chemistry ; Silver Compounds/pharmacology ; Stereoisomerism ; Substrate Specificity ; beta Carotene/chemistry ; beta Carotene/metabolism ; cis-trans-Isomerases/chemistry ; cis-trans-Isomerases/genetics ; cis-trans-Isomerases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effects of viruses on bacterial functions under contrasting nutritional conditions for four species of bacteria isolated from Hong Kong waters.
Autorzy:
Liu H; School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, 510006.; Key Laboratory of Marine Resources and Coastal Engineering in Guangdong Province, Guangzhou, China, 510006.
Yuan X; Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China.
Xu J; State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China.
Harrison PJ; Department of Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
He L; School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, 510006.; Key Laboratory of Marine Resources and Coastal Engineering in Guangdong Province, Guangzhou, China, 510006.
Yin K; School of Marine Sciences, Sun Yat-sen University, Guangzhou, China, 510006.; Key Laboratory of Marine Resources and Coastal Engineering in Guangdong Province, Guangzhou, China, 510006.
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Źródło:
Scientific reports [Sci Rep] 2015 Sep 25; Vol. 5, pp. 14217. Date of Electronic Publication: 2015 Sep 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bacterial Physiological Phenomena*
Microbial Interactions*
Virus Physiological Phenomena*
Water Microbiology*
Bacteria/isolation & purification ; Bacteria/virology ; Hong Kong ; Seawater/microbiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effects of cognitive behavioural therapy for insomnia on the mental health of university students: study protocol for a randomized controlled trial.
Autorzy:
Freeman D; Sleep & Circadian Neuroscience Institute, Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, UK. .
Sheaves B; Sleep & Circadian Neuroscience Institute, Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, UK. .
Goodwin GM; Sleep & Circadian Neuroscience Institute, Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, UK. .
Yu LM; Nuffield Department of Primary Care Health Sciences, University of Oxford, Gibson Building 1st Floor, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. .
Harrison PJ; Sleep & Circadian Neuroscience Institute, Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, UK. Paul.harrison@psych.ox.ac.uk.
Emsley R; Centre for Biostatistics, Institute of Population Health, The University of Manchester, Manchester Academic Health Science Centre, 1.304 Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, UK. .
Bostock S; Sleepio Ltd, 60-62 Commercial Street, London, E1 6LT, UK. .
Foster RG; Sleep & Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 5-6 West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK. .
Wadekar V; Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, UK. .
Hinds C; Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, UK. .
Espie CA; Sleepio Ltd, 60-62 Commercial Street, London, E1 6LT, UK. .; Sleep & Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 5-6 West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK. .
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Źródło:
Trials [Trials] 2015 May 28; Vol. 16, pp. 236. Date of Electronic Publication: 2015 May 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cognitive Behavioral Therapy*
Mental Health*
Sleep*
Sleep Initiation and Maintenance Disorders*/diagnosis
Sleep Initiation and Maintenance Disorders*/psychology
Sleep Initiation and Maintenance Disorders*/therapy
Students*/psychology
Universities*
Adolescent ; Adult ; Female ; Humans ; Male ; Young Adult ; Hallucinations/prevention & control ; Hallucinations/psychology ; Intention to Treat Analysis ; Paranoid Behavior ; Paranoid Disorders/prevention & control ; Paranoid Disorders/psychology ; Psychiatric Status Rating Scales ; Research Design ; Single-Blind Method ; Time Factors ; Treatment Outcome ; United Kingdom ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.
Autorzy:
Pritchett D; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Jagannath A; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom; F.Hoffman-La Roche, Neuroscience, Ophthalmology & Rare Diseases (NORD), Pharma Research & Early Development (pRED) Innovation Centre, Basel, Switzerland.
Brown LA; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Tam SK; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Hasan S; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Gatti S; F.Hoffman-La Roche, Neuroscience, Ophthalmology & Rare Diseases (NORD), Pharma Research & Early Development (pRED) Innovation Centre, Basel, Switzerland.
Harrison PJ; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, United Kingdom.
Bannerman DM; Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, United Kingdom.
Foster RG; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
Peirson SN; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom.
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Źródło:
PloS one [PLoS One] 2015 May 07; Vol. 10 (5), pp. e0125523. Date of Electronic Publication: 2015 May 07 (Print Publication: 2015).
Typ publikacji:
Journal Article
MeSH Terms:
Circadian Rhythm*
Light*
Physical Conditioning, Animal*
Receptors, Metabotropic Glutamate/*physiology
Allosteric Regulation ; Animals ; Locomotion ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Metabotropic Glutamate/genetics ; Sleep
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption.
Autorzy:
Pritchett D; Nuffield Department of Clinical Neurosciences (Nuffield Laboratory of Ophthalmology), John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
Hasan S
Tam SK
Engle SJ
Brandon NJ
Sharp T
Foster RG
Harrison PJ
Bannerman DM
Peirson SN
Pokaż więcej
Źródło:
The European journal of neuroscience [Eur J Neurosci] 2015 May; Vol. 41 (9), pp. 1167-79. Date of Electronic Publication: 2015 Mar 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Circadian Rhythm*
Memory, Short-Term*
Sleep*
Anxiety/*metabolism
D-Amino-Acid Oxidase/*metabolism
Animals ; Anxiety/physiopathology ; Avoidance Learning ; D-Amino-Acid Oxidase/genetics ; Female ; Gene Deletion ; Male ; Maze Learning ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients.
Autorzy:
Smith AM; Microbial Diseases, Eastman Dental Institute, University College London, London, UK.
Sewell GW
Levine AP
Chew TS
Dunne J
O'Shea NR
Smith PJ
Harrison PJ
Macdonald CM
Bloom SL
Segal AW
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Źródło:
Immunology [Immunology] 2015 Jan; Vol. 144 (1), pp. 45-55.
Typ publikacji:
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Crohn Disease/*immunology
Cytokines/*immunology
Gene Expression Regulation/*immunology
Macrophages/*immunology
Transcription Factor TFIIIA/*immunology
Adult ; Cell Cycle Proteins ; Cell Line, Tumor ; Crohn Disease/pathology ; Female ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Macrophages/pathology ; Male ; Membrane Transport Proteins ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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