Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Hassanein EHM"" wg kryterium: Autor


Wyświetlanie 1-19 z 19
Tytuł :
Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats
Autorzy :
Hassanein EHM
Abd El-Ghafar OAM
Ahmed MA
Sayed AM
Gad-Elrab WM
Ajarem JS
Allam AA
Mahmoud AM
Pokaż więcej
Temat :
chemotherapy
acetovanillone
edaravone
oxidative stress
cardiotoxicity
nrf2
mtor.
Therapeutics. Pharmacology
RM1-950
Źródło :
Drug Design, Development and Therapy, Vol Volume 14, Pp 5275-5288 (2020)
Opis pliku :
electronic resource
Relacje :
https://www.dovepress.com/edaravone-and-acetovanillone-upregulate-nrf2-and-pi3kaktmtor-signaling-peer-reviewed-article-DDDT; https://doaj.org/toc/1177-8881
Dostęp URL :
https://doaj.org/article/ebd3b02ea4ab4973a76e1328627ada7b
Czasopismo naukowe
Tytuł :
Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity.
Autorzy :
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt. Electronic address: .
Sayed AM; Biochemistry Laboratory, Chemistry Department, Faculty of Science, Assiut University, Egypt.
El-Bahrawy AH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
Omar ZMM; Department of Pharmacology, College of Medicine, Al-Azhar University, Assiut 71524, Egypt.
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt.
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2021 Jun 15; Vol. 275, pp. 119349. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*chemically induced
Diosmin/*therapeutic use
Gentamicins/*toxicity
Kelch-Like ECH-Associated Protein 1/*metabolism
Oncogene Protein v-akt/*metabolism
PPAR gamma/*metabolism
Signal Transduction/*drug effects
Acute Kidney Injury/pathology ; Acute Kidney Injury/prevention & control ; Animals ; Blotting, Western ; Creatinine/blood ; Diosmin/pharmacology ; Kidney/drug effects ; Kidney/pathology ; Male ; NF-E2-Related Factor 2/metabolism ; Rats ; Rats, Wistar ; Urea/blood ; Uric Acid/blood
Czasopismo naukowe
Tytuł :
Diallyl disulfide ameliorates methotrexate-induced nephropathy in rats: Molecular studies and network pharmacology analysis.
Autorzy :
Hassanein EHM; Faculty of Pharmacy, Department of Pharmacology & Toxicology, Al-Azhar University, Assiut, Egypt.
Mohamed WR; Faculty of Pharmacy, Department of Pharmacology and Toxicology, Beni-Suef University, Beni-Suef, Egypt.
Khalaf MM; Faculty of Pharmacy, Department of Pharmacology and Toxicology, Beni-Suef University, Beni-Suef, Egypt.
Shalkami AS; Faculty of Pharmacy, Department of Pharmacology & Toxicology, Al-Azhar University, Assiut, Egypt.
Sayed AM; Biochemistry Laboratory, Faculty of Science, Chemistry Department, Assiut University, Assiut, Egypt.
Hemeida RAM; Faculty of Pharmacy, Department of Pharmacology & Toxicology, Al-Azhar University, Assiut, Egypt.; Faculty of Pharmacy, Department of Pharmacology and Toxicology, Deraya University, Menia, Egypt.
Pokaż więcej
Źródło :
Journal of food biochemistry [J Food Biochem] 2021 Jun; Vol. 45 (6), pp. e13765. Date of Electronic Publication: 2021 May 16.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Roflumilast protects from cisplatin-induced testicular toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Role of NF-κB-p65, cAMP/PKA and Nrf2/HO-1, NQO1 signaling.
Autorzy :
Abdel-Wahab BA; Department of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia; Department of Medical Pharmacology, College of Medicine, Assiut University, Assiut, Egypt. Electronic address: .
Walbi IA; Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Albarqi HA; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Pokaż więcej
Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2021 May; Vol. 151, pp. 112133. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.
Autorzy :
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
El-Bahrawy AH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Omar ZMM; Department of Pharmacology, College of Medicine, Al-Azhar University, Assiut, Egypt.
Rashwan EK; Department of Physiology, College of Medicine, Al-Azhar University, Assiut, Egypt.
Abdel-Wahab BA; Department of Pharmacology, School of Pharmacy, Najran University, Najran, Saudi Arabia.; Department of Pharmacology, Assiut University, Assiut, Egypt.
Abd-Elhamid TH; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Pokaż więcej
Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2021 May; Vol. 35 (5), pp. e22738. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Trans-ferulic acid ameliorates cisplatin-induced testicular damage via suppression of TLR4, P38-MAPK, and ERK1/2 signaling pathways.
Autorzy :
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Abdel-Wahab BA; Department of Pharmacology, School of Pharmacy, Najran University, P.O. 1988, Najran, Saudi Arabia.; Department of Medical Pharmacology, College of Medicine, Assiut University, Assiut, Egypt.
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. .
Abd El-Ghafar OAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.
Kozman MR; Clinical Pharmacology Department, Faculty of Pharmacy, Misr University for Science and Technology, Cairo, Egypt.
Sharkawi SMZ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Pokaż więcej
Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Apr 01. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Agomelatine prevents gentamicin nephrotoxicity by attenuating oxidative stress and TLR-4 signaling, and upregulating PPARγ and SIRT1.
Autorzy :
Mahmoud AM; Physiology Division, Zoology Department, Faculty of Science, Bni-Suef University, Beni-Suef, Egypt; Biotechnology Department, Research Institute of Medicinal and Aromatic Plants, Beni-Suef University, Beni-Suef, Egypt. Electronic address: .
Abd El-Ghafar OAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.
Alzoghaibi MA; Physiology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2021 Aug 01; Vol. 278, pp. 119600. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Rebamipide potentially mitigates methotrexate-induced nephrotoxicity via inhibition of oxidative stress and inflammation: A molecular and histochemical study.
Autorzy :
Elmansy RA; Department of Anatomy and Embryology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.; Anatomy Unit, Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Seleem HS; Histology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.; Histology Unit, Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
Mahmoud AR; Anatomy Unit, Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Buraydah, Saudi Arabia.; Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Pokaż więcej
Źródło :
Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2021 Mar; Vol. 304 (3), pp. 647-661. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Alanine/*analogs & derivatives
Antioxidants/*therapeutic use
Inflammation/*metabolism
Kidney/*drug effects
Kidney Diseases/*drug therapy
Methotrexate/*adverse effects
Oxidative Stress/*drug effects
Quinolones/*pharmacology
Alanine/pharmacology ; Alanine/therapeutic use ; Animals ; Antimetabolites, Antineoplastic/adverse effects ; Antioxidants/pharmacology ; Kidney/metabolism ; Kidney Diseases/metabolism ; Male ; NF-E2-Related Factor 2/metabolism ; Quinolones/therapeutic use ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-κB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways.
Autorzy :
Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. .
Kozman MR; Clinical Pharmacology Department, Faculty of Pharmacy, Misr University for Science and Technology, Cairo, Egypt.
Abd El-Ghafar OAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.
Pokaż więcej
Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Mar; Vol. 28 (9), pp. 11558-11571. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article
MeSH Terms :
Gentamicins*/toxicity
NF-kappa B*/metabolism
Animals ; Kidney/metabolism ; Rats ; Signal Transduction ; Toll-Like Receptor 4 ; Umbelliferones/pharmacology
Czasopismo naukowe
Tytuł :
Flavonoids-mediated SIRT1 signaling activation in hepatic disorders.
Autorzy :
Sayed AM; Biochemistry Laboratory, Chemistry Department, Faculty of Science, Assiut University, Egypt.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University-Assiut Branch, Egypt.
Salem SH; Department of Botany and Microbiology, Faculty of Science, Assiut University, Egypt.
Hussein OE; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt.
Mahmoud AM; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2020 Oct 15; Vol. 259, pp. 118173. Date of Electronic Publication: 2020 Aug 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Flavonoids/*therapeutic use
Liver Diseases/*drug therapy
Signal Transduction/*drug effects
Sirtuin 1/*drug effects
Animals ; Flavonoids/pharmacology ; Humans ; Liver Diseases/physiopathology ; Plants/chemistry
Czasopismo naukowe
Tytuł :
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways.
Autorzy :
Abdel-Wahab BA; Department of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia.; Department of Medical Pharmacology, College of Medicine, Assiut University, Assiut, Egypt.
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Alkahtani SA; Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Alshabi AM; Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Mahnashi MH; Department of Pharmaceutical Chemistry, College of Pharmacy, Najran University, Najran, Saudi Arabia.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Pokaż więcej
Źródło :
Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2020 Oct; Vol. 42 (5), pp. 493-503. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Ursodeoxycholic acid abrogates gentamicin-induced hepatotoxicity in rats: Role of NF-κB-p65/TNF-α, Bax/Bcl-xl/Caspase-3, and eNOS/iNOS pathways.
Autorzy :
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt. Electronic address: .
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Bakr AG; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
El-Shoura EAM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
El-Gamal DA; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mahmoud AR; Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Anatomy, Unaizah College of Medicine, Qassim University, Unaizah Al Qassim Region, Saudi Arabia.
Abd-Elhamid TH; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2020 Aug 01; Vol. 254, pp. 117760. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article
MeSH Terms :
Chemical and Drug Induced Liver Injury/*prevention & control
Gentamicins/*antagonists & inhibitors
Gentamicins/*toxicity
Hepatocytes/*drug effects
Signal Transduction/*drug effects
Ursodeoxycholic Acid/*pharmacology
Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Drug Interactions ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Male ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/metabolism ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Oxidative Stress/drug effects ; Random Allocation ; Rats ; Rats, Wistar ; Transcription Factor RelA/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; bcl-2-Associated X Protein/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Perindopril Ameliorates Hepatic Ischemia Reperfusion Injury Via Regulation of NF-κB-p65/TLR-4, JAK1/STAT-3, Nrf-2, and PI3K/Akt/mTOR Signaling Pathways.
Autorzy :
Kamel EO; Department of Medical Histology and Cell Biology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Ahmed MA; Department of Pharmacology, Faculty of Medicine, Assiut University, Asyut, Egypt.
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Pokaż więcej
Źródło :
Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2020 Jul; Vol. 303 (7), pp. 1935-1949. Date of Electronic Publication: 2019 Nov 06.
Typ publikacji :
Journal Article
MeSH Terms :
Angiotensin-Converting Enzyme Inhibitors/*pharmacology
Liver/*blood supply
Perindopril/*pharmacology
Reperfusion Injury/*drug therapy
Signal Transduction/*drug effects
Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Animals ; Biomarkers/blood ; Janus Kinase 1/metabolism ; Liver/metabolism ; Male ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Oxidative Stress/drug effects ; Perindopril/therapeutic use ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Reperfusion Injury/metabolism ; STAT3 Transcription Factor/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Toll-Like Receptor 4/metabolism
Czasopismo naukowe
Tytuł :
New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies.
Autorzy :
Fadaly WAA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Elshaier YAMM; Organic & Medicinal Chemistry Department, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 7152, Egypt.
Abdellatif KRA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt; Pharmaceutical Sciences Department, Ibn Sina National College for Medical Studies, Jeddah 21418, Saudi Arabia. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 May; Vol. 98, pp. 103752. Date of Electronic Publication: 2020 Mar 12.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Antineoplastic Agents/*pharmacology
Celecoxib/*pharmacology
Cyclooxygenase 2 Inhibitors/*pharmacology
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Celecoxib/chemical synthesis ; Celecoxib/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/chemical synthesis ; Cyclooxygenase 2 Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Male ; Models, Molecular ; Molecular Structure ; Nitric Oxide/metabolism ; Oximes/chemistry ; Oximes/pharmacology ; PC-3 Cells ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Rats ; Rats, Wistar ; Stomach Ulcer/drug therapy ; Structure-Activity Relationship ; Triazoles/chemistry ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway.
Autorzy :
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University-Assiut Branch, Egypt.
Sayed AM; Biochemistry Laboratory, Chemistry Department, Faculty of Science, Assiut University, Egypt.
Hussein OE; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt.
Mahmoud AM; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Egypt.
Pokaż więcej
Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2020 Apr 22; Vol. 2020, pp. 1675957. Date of Electronic Publication: 2020 Apr 22 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antioxidant Response Elements/*drug effects
Coumarins/*pharmacology
Kelch-Like ECH-Associated Protein 1/*metabolism
NF-E2-Related Factor 2/*metabolism
Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Antioxidants/pharmacology ; Humans ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Coenzyme Q 10 protects hepatocytes from ischemia reperfusion-induced apoptosis and oxidative stress via regulation of Bax/Bcl-2/PUMA and Nrf-2/FOXO-3/Sirt-1 signaling pathways.
Autorzy :
Mahmoud AR; Department of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Anatomy, Unaizah College of Medicine, Qassim University, Unaizah Al Qassim Region, Saudi Arabia.
Ali FEM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. Electronic address: .
Abd-Elhamid TH; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Pokaż więcej
Źródło :
Tissue & cell [Tissue Cell] 2019 Oct; Vol. 60, pp. 1-13. Date of Electronic Publication: 2019 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Oxidative Stress/*drug effects
Reperfusion Injury/*drug therapy
Signal Transduction/*drug effects
Ubiquinone/*analogs & derivatives
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Apoptosis Regulatory Proteins/metabolism ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Liver/physiopathology ; Male ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Reperfusion Injury/pathology ; Ubiquinone/pharmacology ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
The impact of Keap1/Nrf2, P 38 MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity.
Autorzy :
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524 Egypt.
Shalkami AS; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524 Egypt. Electronic address: .
Khalaf MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514 Egypt.
Mohamed WR; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514 Egypt.
Hemeida RAM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524 Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Deraya University, Menia, 61768 Egypt.
Pokaż więcej
Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2019 Jan; Vol. 109, pp. 47-56. Date of Electronic Publication: 2018 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Antimetabolites, Antineoplastic/*toxicity
Berberine/*pharmacology
Kidney/*drug effects
Methotrexate/*toxicity
Animals ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/pharmacology ; Caspase 3/metabolism ; Cell Line, Tumor ; Humans ; Kelch-Like ECH-Associated Protein 1 ; Kidney/pathology ; Male ; Methotrexate/administration & dosage ; Methotrexate/pharmacology ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Neoplasms/drug therapy ; Neoplasms/pathology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Signal Transduction/drug effects ; bcl-2-Associated X Protein/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Reno-protective effects of ursodeoxycholic acid against gentamicin-induced nephrotoxicity through modulation of NF-κB, eNOS and caspase-3 expressions.
Autorzy :
Abd-Elhamid TH; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt. .
Elgamal DA; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ali SS; Department of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ali FEM; Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Hassanein EHM; Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
El-Shoura EAM; Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Hemeida RAM; Department of Pharmacology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
Pokaż więcej
Źródło :
Cell and tissue research [Cell Tissue Res] 2018 Nov; Vol. 374 (2), pp. 367-387. Date of Electronic Publication: 2018 Aug 04.
Typ publikacji :
Journal Article
MeSH Terms :
Caspase 3/*metabolism
Gentamicins/*adverse effects
Kidney/*pathology
NF-kappa B/*metabolism
Nitric Oxide Synthase Type III/*metabolism
Ursodeoxycholic Acid/*pharmacology
Animals ; Biomarkers/metabolism ; Kidney/physiopathology ; Kidney/ultrastructure ; Kidney Function Tests ; Lipid Peroxidation/drug effects ; Male ; NF-kappa B/genetics ; Nitric Oxide/biosynthesis ; Nitrosative Stress/drug effects ; Oxidative Stress/drug effects ; Peroxidase/metabolism ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Renoprotective effects of umbelliferone on methotrexate-induced renal injury through regulation of Nrf-2/Keap-1, P 38 MAPK/NF-κB, and apoptosis signaling pathways.
Autorzy :
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Mohamed WR; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: .
Shalkami AS; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Khalaf MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Hemeida RAM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Pokaż więcej
Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2018 Jun; Vol. 116 (Pt B), pp. 152-160. Date of Electronic Publication: 2018 Mar 30.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Kidney/*drug effects
Methotrexate/*toxicity
Signal Transduction/*drug effects
Umbelliferones/*pharmacology
Animals ; Kelch-Like ECH-Associated Protein 1/metabolism ; Kidney/metabolism ; Male ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Rats ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
    Wyświetlanie 1-19 z 19

    Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies