Addition of inflammation-related biomarkers to the CAIDE model for risk prediction of all-cause dementia, Alzheimer's disease and vascular dementia in a prospective study.
Autorzy:
Trares K; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, 69120, Germany. Wiesenfarth M; Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany. Stocker H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, 69120, Germany. Perna L; Department of Genes and Environment, Max Planck Institute of Psychiatry, Kraepelinstraße 2-10, Munich, 80804, Germany.; Division of Mental Health of Older Adults, Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, 80336, Germany. Petrera A; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. HauckSM; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. Beyreuther K; Network Aging Research, Heidelberg University, Bergheimer Straße 20, Heidelberg, 69115, Germany. Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, 69120, Germany. Schöttker B; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, 69120, Germany. .
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Immunity & ageing : I & A [Immun Ageing] 2024 Apr 03; Vol. 21 (1), pp. 23. Date of Electronic Publication: 2024 Apr 03.
Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis.
Autorzy:
Pott J; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. .; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK. . Kheirkhah A; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria. Gadin JR; Division of Cardiovascular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Solna, Sweden. Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany. Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Kirsten H; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Forer L; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria. HauckSM; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Burkhardt R; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. Scharnagl H; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. März W; Vth Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.; SYNLAB Academy, Synlab Holding Deutschland GmbH, Mannheim and Augsburg, Germany. Thiery J; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.; Faculty of Medicine, University of Kiel, Kiel, Germany. Gieger C; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Silveira A; Division of Cardiovascular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Solna, Sweden. Hooft FV; Division of Cardiovascular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Solna, Sweden. Kronenberg F; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria. Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. .; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. .
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Biology of sex differences [Biol Sex Differ] 2024 Mar 26; Vol. 15 (1), pp. 26. Date of Electronic Publication: 2024 Mar 26.
Association of plasma proteomics with incident coronary heart disease in individuals with and without type 2 diabetes: results from the population-based KORA study.
Autorzy:
Luo H; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstraße 1, D-85764, Neuherberg, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Pettenkofer School of Public Health, Munich, Germany. Huemer MT; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstraße 1, D-85764, Neuherberg, Germany. Petrera A; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. HauckSM; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.; German Center for Diabetes Research (DZD), Partner München-Neuherberg, Neuherberg, Germany. Rathmann W; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine Universität, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany. Herder C; German Center for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine Universität, Düsseldorf, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine Universität, Düsseldorf, Germany. Koenig W; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany. Hoyer A; Biostatistics and Medical Biometry, Medical School OWL, Bielefeld University, Bielefeld, Germany. Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstraße 1, D-85764, Neuherberg, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Pettenkofer School of Public Health, Munich, Germany.; German Center for Diabetes Research (DZD), Partner München-Neuherberg, Neuherberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany. Thorand B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstaedter Landstraße 1, D-85764, Neuherberg, Germany. .; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Pettenkofer School of Public Health, Munich, Germany. .; German Center for Diabetes Research (DZD), Partner München-Neuherberg, Neuherberg, Germany. .
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Cardiovascular diabetology [Cardiovasc Diabetol] 2024 Feb 03; Vol. 23 (1), pp. 53. Date of Electronic Publication: 2024 Feb 03.
The glucocorticoid receptor as a master regulator of the Müller cell response to diabetic conditions in mice.
Autorzy:
Pfaller AM; Department of Physiological Genomics, Biomedical Center-BMC, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany. Kaplan L; Department of Physiological Genomics, Biomedical Center-BMC, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany. Carido M; Helmholtz Pioneer Campus, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Grassmann F; Institute of Clinical Human Genetics, University Hospital Regensburg, Regensburg, Germany.; Institute for Clinical Research and Systems Medicine, Health and Medical University, Potsdam, Germany. Díaz-Lezama N; Department of Physiological Genomics, Biomedical Center-BMC, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany. Ghaseminejad F; Department of Physiological Genomics, Biomedical Center-BMC, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany. Wunderlich KA; Department of Physiological Genomics, Biomedical Center-BMC, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Institute for Molecular Medicine, Health and Medical University, Potsdam, Germany. Glänzer S; Department of Physiological Genomics, Biomedical Center-BMC, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany. Bludau O; Department of Physiological Genomics, Biomedical Center-BMC, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany. Pannicke T; Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany. Weber BHF; Institute of Clinical Human Genetics, University Hospital Regensburg, Regensburg, Germany.; Institute of Human Genetics, University Regensburg, Regensburg, Germany. Koch SF; Department of Physiological Genomics, Biomedical Center-BMC, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany. Bonev B; Department of Physiological Genomics, Biomedical Center-BMC, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Helmholtz Pioneer Campus, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. HauckSM; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Grosche A; Department of Physiological Genomics, Biomedical Center-BMC, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany. .
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Journal of neuroinflammation [J Neuroinflammation] 2024 Jan 25; Vol. 21 (1), pp. 33. Date of Electronic Publication: 2024 Jan 25.
A Lysine Residue at the C-Terminus of MHC Class I Ligands Correlates with Low C-Terminal Proteasomal Cleavage Probability.
Autorzy:
Schmalen A; Chair of Physiology, Department of Veterinary Sciences, LMU Munich, Martinsried, 82152 Planegg, Germany.; Core Facility-Metabolomics and Proteomics Core, Helmholtz Center Munich, German Research Center for Environmental Health (GmbH), 80939 Munich, Germany. Kammerl IE; Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians-University, Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), 81377 Munich, Germany. Meiners S; Research Center Borstel, Leibniz Lung Center, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), 23845 Borstel, Germany.; Institute of Experimental Medicine, Christian-Albrechts University Kiel, 24118 Kiel, Germany. Noessner E; Immunoanalytics Research Group-Tissue Control of Immunocytes, Helmholtz Center Munich, 81377 Munich, Germany. Deeg CA; Chair of Physiology, Department of Veterinary Sciences, LMU Munich, Martinsried, 82152 Planegg, Germany. HauckSM; Core Facility-Metabolomics and Proteomics Core, Helmholtz Center Munich, German Research Center for Environmental Health (GmbH), 80939 Munich, Germany.
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Biomolecules [Biomolecules] 2023 Aug 24; Vol. 13 (9). Date of Electronic Publication: 2023 Aug 24.
Proteomic profiling of longitudinal changes in kidney function among middle-aged and older men and women: the KORA S4/F4/FF4 study.
Autorzy:
Lin JS; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.; Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Pettenkofer School of Public Health, Munich, Germany. Nano J; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.; Chair of Epidemiology, Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-Universität München, Munich, Germany. Petrera A; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. HauckSM; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. Zeller T; University Center of Cardiovascular Science, University Heart and Vascular Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Hamburg, Germany. Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany. Müller CL; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.; Helmholtz AI, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.; Department of Statistics, Ludwig-Maximilians-Universität München, Munich, Germany.; Center for Computational Mathematics, Flatiron Institute, New York, USA. Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.; Chair of Epidemiology, Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Diabetes Research (DZD), Partner München-Neuherberg, Neuherberg, Germany. Thorand B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, 85764, Neuherberg, Germany. .; German Center for Diabetes Research (DZD), Partner München-Neuherberg, Neuherberg, Germany. .
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BMC medicine [BMC Med] 2023 Jul 05; Vol. 21 (1), pp. 245. Date of Electronic Publication: 2023 Jul 05.
Effects of GHR Deficiency and Juvenile Hypoglycemia on Immune Cells of a Porcine Model for Laron Syndrome.
Autorzy:
Schilloks MC; Chair of Animal Physiology, Department of Veterinary Sciences, LMU Munich, D-82152 Martinsried, Germany. Giese IM; Chair of Animal Physiology, Department of Veterinary Sciences, LMU Munich, D-82152 Martinsried, Germany. Hinrichs A; Chair of Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, D-85764 Oberschleißheim, Germany. Korbonits L; Chair of Animal Physiology, Department of Veterinary Sciences, LMU Munich, D-82152 Martinsried, Germany. HauckSM; Metabolomics and Proteomics Core, Helmholtz Center Munich, German Research Center for Environmental Health, D-80939 Munich, Germany. Wolf E; Chair of Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, D-85764 Oberschleißheim, Germany. Deeg CA; Chair of Animal Physiology, Department of Veterinary Sciences, LMU Munich, D-82152 Martinsried, Germany.
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Biomolecules [Biomolecules] 2023 Mar 26; Vol. 13 (4). Date of Electronic Publication: 2023 Mar 26.
Non-Oncogene Addiction of KRAS -Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ.
Autorzy:
Spella M; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Ntaliarda G; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Skiadas G; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Lamort AS; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Vreka M; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Marazioti A; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Lilis I; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Bouloukou E; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Giotopoulou GA; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Pepe MAA; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Weiss SAI; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Petrera A; Research Unit Protein Science-Core Facility Proteomics, Helmholtz Center Munich-German Research Center for Environmental Health, 80939 Munich, Germany. HauckSM; Research Unit Protein Science-Core Facility Proteomics, Helmholtz Center Munich-German Research Center for Environmental Health, 80939 Munich, Germany. Koch I; Center for Thoracic Surgery Munich, Ludwig-Maximilians-University of Munich and Asklepios Medical Center, 82131 Gauting, Germany. Lindner M; Center for Thoracic Surgery Munich, Ludwig-Maximilians-University of Munich and Asklepios Medical Center, 82131 Gauting, Germany. Hatz RA; Center for Thoracic Surgery Munich, Ludwig-Maximilians-University of Munich and Asklepios Medical Center, 82131 Gauting, Germany. Behr J; Department of Internal Medicine V, Ludwig-Maximilian-University of Munich, 81377 Munich, Germany. Arendt KAM; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Giopanou I; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany. Brunn D; Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany. Savai R; Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.; Frankfurt Cancer Institute (FCI), Goethe University, 60596 Frankfurt am Main, Germany.; Department of Internal Medicine and Institute for Lung Health (ILH), Justus Liebig University, 35392 Giessen, Germany. Jenne DE; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany.; Max-Planck-Institute of Neurobiology, 82152 Planegg, Germany. de Château M; Buzzard Pharmaceutical, 17165 Stockholm, Sweden. Yull FE; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA. Blackwell TS; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37240, USA. Stathopoulos GT; Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.; Comprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany.; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
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Cancers [Cancers (Basel)] 2023 Mar 20; Vol. 15 (6). Date of Electronic Publication: 2023 Mar 20.
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation.
Autorzy:
Todorova V; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland. Stauffacher MF; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland. Ravotto L; Institute of Pharmacology and Toxicology and Neuroscience Center Zurich, University and ETH Zurich, Winterthurerstr. 190, 8057, Zurich, Switzerland. Nötzli S; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland. Karademir D; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland. Ebner LJA; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland. Imsand C; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland. Merolla L; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland. HauckSM; Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, 85764, Munich, Germany. Samardzija M; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland. Saab AS; Institute of Pharmacology and Toxicology and Neuroscience Center Zurich, University and ETH Zurich, Winterthurerstr. 190, 8057, Zurich, Switzerland. Barros LF; Centro de Estudios Científicos (CECs), Valdivia, Chile.; Universidad San Sebastián, Valdivia, Chile. Weber B; Institute of Pharmacology and Toxicology and Neuroscience Center Zurich, University and ETH Zurich, Winterthurerstr. 190, 8057, Zurich, Switzerland. Grimm C; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland. .
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Molecular neurodegeneration [Mol Neurodegener] 2023 Mar 07; Vol. 18 (1), pp. 15. Date of Electronic Publication: 2023 Mar 07.
Proteomics biomarker discovery for individualized prevention of familial pancreatic cancer using statistical learning.
Autorzy:
Ha CSR; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Faculty of Medicine, Institute for Medical Information Processing, Chair of Genetic Epidemiology, Biometry, and Epidemiology (IBE), LMU Munich, Munich, Germany. Müller-Nurasyid M; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Faculty of Medicine, Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Munich, Munich, Germanys.; Faculty of Medicine, Institute for Medical Information Processing, Pettenkofer School of Public Health Munich, Biometry, and Epidemiology (IBE), LMU Munich, Munich, Germany. Petrera A; Research Unit Protein Science and Metabolomics and Proteomics Core Facility, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. HauckSM; Research Unit Protein Science and Metabolomics and Proteomics Core Facility, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Marini F; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Research Center for Immunotherapy (FZI), University Medical Center, Johannes Gutenberg University, Mainz, Germany. Bartsch DK; Department of Visceral-, Thoracic- and Vascular Surgery, Philipps University, Marburg, Germany. Slater EP; Department of Visceral-, Thoracic- and Vascular Surgery, Philipps University, Marburg, Germany. Strauch K; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Faculty of Medicine, Institute for Medical Information Processing, Chair of Genetic Epidemiology, Biometry, and Epidemiology (IBE), LMU Munich, Munich, Germany.
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PloS one [PLoS One] 2023 Jan 26; Vol. 18 (1), pp. e0280399. Date of Electronic Publication: 2023 Jan 26 (Print Publication: 2023).
Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study.
Autorzy:
Trares K; Network Aging Research, Heidelberg University, Bergheimer Straße 20, 69115, Heidelberg, Germany.; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.; Medical Faculty, Heidelberg University, Im Neuenheimer Feld 672, 69120, Heidelberg, Germany. Bhardwaj M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. Perna L; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstraße 2-10, 80804, Munich, Germany.; Division of Mental Health of Older Adults, Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, 80336, Munich, Germany. Stocker H; Network Aging Research, Heidelberg University, Bergheimer Straße 20, 69115, Heidelberg, Germany.; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.; Medical Faculty, Heidelberg University, Im Neuenheimer Feld 672, 69120, Heidelberg, Germany. Petrera A; Research Unit Protein Science and Metabolomics and Proteomics Core Facility, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Heidemannstraße 1, 80939, Munich, Germany. HauckSM; Research Unit Protein Science and Metabolomics and Proteomics Core Facility, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Heidemannstraße 1, 80939, Munich, Germany. Beyreuther K; Network Aging Research, Heidelberg University, Bergheimer Straße 20, 69115, Heidelberg, Germany. Brenner H; Network Aging Research, Heidelberg University, Bergheimer Straße 20, 69115, Heidelberg, Germany.; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. Schöttker B; Network Aging Research, Heidelberg University, Bergheimer Straße 20, 69115, Heidelberg, Germany. .; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. .
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Alzheimer's research & therapy [Alzheimers Res Ther] 2022 Sep 09; Vol. 14 (1), pp. 128. Date of Electronic Publication: 2022 Sep 09.
Release of VAMP5-positive extracellular vesicles by retinal Müller glia in vivo.
Autorzy:
Demais V; Plateforme Imagerie In Vitro, CNRS UAR 3156, Neuropôle, University of Strasbourg, Strasbourg, France. Pohl A; Department of Physiological Genomics, BioMedical Center BMC, Ludwig-Maximilian University, Planegg-Martinsried, Germany.; Institute of Human Genetics, University of Regensburg, Regensburg, Germany. Wunderlich KA; Department of Physiological Genomics, BioMedical Center BMC, Ludwig-Maximilian University, Planegg-Martinsried, Germany. Pfaller AM; Department of Physiological Genomics, BioMedical Center BMC, Ludwig-Maximilian University, Planegg-Martinsried, Germany. Kaplan L; Department of Physiological Genomics, BioMedical Center BMC, Ludwig-Maximilian University, Planegg-Martinsried, Germany. Barthélémy A; Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France. Dittrich R; Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. Puig B; Neurology Department, Experimental Research in Stroke and Inflammation (ERSI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Giebel B; Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. HauckSM; Metabolomics and Proteomics Core and Research Unit Protein Science, Helmholtz-Zentrum München, München, Germany. Pfrieger FW; Plateforme Imagerie In Vitro, CNRS UAR 3156, Neuropôle, University of Strasbourg, Strasbourg, France.; Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France. Grosche A; Department of Physiological Genomics, BioMedical Center BMC, Ludwig-Maximilian University, Planegg-Martinsried, Germany.
Pre-Activated Granulocytes from an Autoimmune Uveitis Model Show Divergent Pathway Activation Profiles upon IL8 Stimulation In Vitro.
Autorzy:
Hoffmann ALC; Chair of Physiology, Department of Veterinary Sciences, LMU Munich, D-82152 Martinsried, Germany. HauckSM; Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health, D-80939 Munich, Germany. Deeg CA; Chair of Physiology, Department of Veterinary Sciences, LMU Munich, D-82152 Martinsried, Germany. Degroote RL; Chair of Physiology, Department of Veterinary Sciences, LMU Munich, D-82152 Martinsried, Germany.
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.
Autorzy:
O'Neill AC; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany. Uzbas F; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany. Antognolli G; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany. Merino F; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany. Draganova K; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany. Jäck A; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany. Zhang S; CAS Key Laboratory of Computational Biology, Biomedical Big Data Center, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China. Pedini G; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. Schessner JP; Max Planck Institute of Biochemistry, Martinsried, Germany. Cramer K; Max Planck Institute of Biochemistry, Martinsried, Germany.; Faculty of Physics and Center for Nanoscience, LMU, Munich, Germany. Schepers A; Monoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany. Metzger F; Research Unit Protein Science and Metabolomics and Proteomics Core, Helmholtz Centre Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany. Esgleas M; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany. Smialowski P; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany. Guerrini R; Neuroscience Department, Children's Hospital Meyer-University of Florence, Florence, Italy. Falk S; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany. Feederle R; Monoclonal Antibody Core Facility, Institute for Diabetes and Obesity, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany.; SYNERGY, Excellence Cluster of Systems Neurology, Biomedical Center, LMU, Planegg-Martinsried, Germany. Freytag S; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia. Wang Z; CAS Key Laboratory of Computational Biology, Biomedical Big Data Center, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China. Bahlo M; Personalised Oncology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia. Jungmann R; Max Planck Institute of Biochemistry, Martinsried, Germany.; Faculty of Physics and Center for Nanoscience, LMU, Munich, Germany. Bagni C; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.; Department of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland. Borner GHH; Max Planck Institute of Biochemistry, Martinsried, Germany. Robertson SP; Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. HauckSM; Research Unit Protein Science and Metabolomics and Proteomics Core, Helmholtz Centre Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany. Götz M; Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universitaet (LMU), Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.; SYNERGY, Excellence Cluster of Systems Neurology, Biomedical Center, LMU, Planegg-Martinsried, Germany.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Jun 17; Vol. 376 (6599), pp. eabf9088. Date of Electronic Publication: 2022 Jun 17.
Genetically regulated gene expression and proteins revealed discordant effects.
Autorzy:
Pott J; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany. Garcia T; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany. HauckSM; Research Unit Protein Science and Metabolomics and Proteomics Core Facility, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Neuherberg, Germany. Petrera A; Research Unit Protein Science and Metabolomics and Proteomics Core Facility, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Neuherberg, Germany. Wirkner K; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany. Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany. Kirsten H; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany. Peters A; Research Unit Protein Science and Metabolomics and Proteomics Core Facility, Helmholtz Zentrum Munich - German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), München-Neuherberg, Germany.; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany. Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany.
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Źródło:
PloS one [PLoS One] 2022 May 23; Vol. 17 (5), pp. e0268815. Date of Electronic Publication: 2022 May 23 (Print Publication: 2022).
Bovine Peripheral Blood Derived Lymphocyte Proteome and Secretome Show Divergent Reaction of Bovine Immune Phenotypes after Stimulation with Pokeweed Mitogen.
Autorzy:
Kleinwort KJH; Department of Veterinary Sciences, LMU Munich, D-82152 Planegg, Germany. Degroote RL; Department of Veterinary Sciences, LMU Munich, D-82152 Planegg, Germany. Hirmer S; Department of Veterinary Sciences, LMU Munich, D-82152 Planegg, Germany. Korbonits L; Department of Veterinary Sciences, LMU Munich, D-82152 Planegg, Germany. Lorenz L; Department of Veterinary Sciences, LMU Munich, D-82152 Planegg, Germany. Scholz AM; Livestock Center of the Faculty of Veterinary Medicine, LMU Munich, D-85764 Oberschleißheim, Germany. HauckSM; Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health, D-80939 Munich, Germany. Deeg CA; Department of Veterinary Sciences, LMU Munich, D-82152 Planegg, Germany.
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Źródło:
Proteomes [Proteomes] 2022 Feb 08; Vol. 10 (1). Date of Electronic Publication: 2022 Feb 08.
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