SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis.
Autorzy:
Castelli LM; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK. Cutillo L; School of Mathematics, University of Leeds, Leeds, LS2 9JT, UK. Souza CDS; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK. Sanchez-Martinez A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK. Granata I; National Research Council of Italy, High Performance Computing and Networking Institute (ICAR-CNR), 111 Via Pietro Castellino, 80131, Naples, Italy. Lin YH; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK. Myszczynska MA; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK. Heath PR; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK. Livesey MR; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Ning K; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Azzouz M; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Guarracino MR; National Research Council of Italy, High Performance Computing and Networking Institute (ICAR-CNR), 111 Via Pietro Castellino, 80131, Naples, Italy. Whitworth AJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK. Ferraiuolo L; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. Milo M; Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. .; Present Address: AstraZeneca, Academy House, 136 Hills Road, Cambridge, CB2 8PA, UK. . HautbergueGM; Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield, S10 2HQ, UK. g.hautbergue@sheffield.ac.uk.; Neuroscience Institute, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. g.hautbergue@sheffield.ac.uk.
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2021 Aug 10; Vol. 16 (1), pp. 53. Date of Electronic Publication: 2021 Aug 10.
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease.
Autorzy:
Gatto N; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Dos Santos Souza C; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Shaw AC; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Bell SM; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Myszczynska MA; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Powers S; The Research institute, Nationwide Children's Hospital, Columbus, OH, USA. Meyer K; The Research institute, Nationwide Children's Hospital, Columbus, OH, USA. Castelli LM; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Karyka E; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Mortiboys H; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Azzouz M; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. HautbergueGM; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Márkus NM; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK. Ferraiuolo L; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
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Źródło:
Aging cell [Aging Cell] 2021 Jan; Vol. 20 (1), pp. e13281. Date of Electronic Publication: 2020 Dec 13.
Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features.
Autorzy:
Shaw MP; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. Higginbottom A; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. McGown A; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. Castelli LM; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. James E; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. HautbergueGM; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. Shaw PJ; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. Ramesh TM; Sheffield Institute for Translational Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. .; The Bateson Centre, Firth Court, The University of Sheffield, Western Bank, Sheffield, S10 2TN, UK. .
Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells.
Autorzy:
Rust A; Structural and Molecular Biology, Division of Biosciences, Faculty of Life Sciences, University College London, London WC1E 6BT, UK. .; Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. . Shah S; Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. .; Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK. . HautbergueGM; Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK. g.hautbergue@sheffield.ac.uk. Davletov B; Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. .
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Źródło:
Toxins [Toxins (Basel)] 2018 Jun 27; Vol. 10 (7). Date of Electronic Publication: 2018 Jun 27.
Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes.
Autorzy:
Morgan SV; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Garwood CJ; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Jennings L; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Simpson JE; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Castelli LM; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Heath PR; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Mihaylov SR; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Vaquéz-Villaseñor I; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Minshull TC; Department of Chemical and Biological Engineering, University of Sheffield, Sheffield, UK. Ince PG; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Dickman MJ; Department of Chemical and Biological Engineering, University of Sheffield, Sheffield, UK. HautbergueGM; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK. Wharton SB; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations.
Autorzy:
Rust A; Structural and Molecular Biology, Division of Biosciences, Faculty of Life Sciences, University College London, London WC1E 6BT, UK. . Partridge LJ; Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. . Davletov B; Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK. . HautbergueGM; Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield S10 2HQ, UK. g.hautbergue@sheffield.ac.uk.
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Źródło:
Toxins [Toxins (Basel)] 2017 Oct 27; Vol. 9 (11). Date of Electronic Publication: 2017 Oct 27.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
Invited review: decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art.
Competitive and cooperative interactions mediate RNA transfer from herpesvirus saimiri ORF57 to the mammalian export adaptor ALYREF.
Autorzy:
Tunnicliffe RB; Manchester Institute of Biotechnology and Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom. HautbergueGM; RNA Biology Laboratory, Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom. Wilson SA; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom. Kalra P; Manchester Institute of Biotechnology and Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom. Golovanov AP; Manchester Institute of Biotechnology and Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom.
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Źródło:
PLoS pathogens [PLoS Pathog] 2014 Feb 13; Vol. 10 (2), pp. e1003907. Date of Electronic Publication: 2014 Feb 13 (Print Publication: 2014).
Ribosome-inactivating proteins: potent poisons and molecular tools.
Autorzy:
Walsh MJ; RNA Biology Laboratory; Sheffield Institute for Translational Neuroscience (SITraN); Department of Neuroscience; University of Sheffield; Sheffield, UK. Dodd JE; RNA Biology Laboratory; Sheffield Institute for Translational Neuroscience (SITraN); Department of Neuroscience; University of Sheffield; Sheffield, UK. HautbergueGM; RNA Biology Laboratory; Sheffield Institute for Translational Neuroscience (SITraN); Department of Neuroscience; University of Sheffield; Sheffield, UK.
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Źródło:
Virulence [Virulence] 2013 Nov 15; Vol. 4 (8), pp. 774-84. Date of Electronic Publication: 2013 Sep 17.
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