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Wyszukujesz frazę ""Healthy Volunteers"" wg kryterium: Temat


Tytuł:
A Phase I, Open-label, Single-Dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of AMG 986 in Healthy Japanese Subjects.
Autorzy:
Trivedi A; Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA, USA. .
Mather O; Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA, USA.
Vega S; Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA, USA.
Hutton S; Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA, USA.
Hellawell J; Amgen Inc., San Francisco, CA, USA.
Lee E; Amgen Inc., 1 Amgen Center Drive, Thousand Oaks, CA, USA.
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Źródło:
Drugs in R&D [Drugs R D] 2022 Jun; Vol. 22 (2), pp. 141-146. Date of Electronic Publication: 2022 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Healthy Volunteers*
Administration, Oral ; Area Under Curve ; Dose-Response Relationship, Drug ; Humans ; Japan
Czasopismo naukowe
Tytuł:
Evaluation of the Pharmacokinetics and Safety of AMG 986 Tablet and Capsule Formulations in Healthy Adult Subjects: A Phase I, Open-Label, Randomized Study.
Autorzy:
Trivedi A; Amgen Inc., Thousand Oaks, CA, 91320, USA. .
Kiang YH; Amgen Inc., Thousand Oaks, CA, 91320, USA.
Saw RE; Amgen Inc., Thousand Oaks, CA, 91320, USA.
Cheng GC; Amgen Inc., Thousand Oaks, CA, 91320, USA.; Foghorn Therapeutics Inc., Cambridge, MA, USA.
Mather O; Amgen Inc., Thousand Oaks, CA, 91320, USA.
Vega S; Amgen Inc., Thousand Oaks, CA, 91320, USA.
Hellawell J; Amgen Inc., San Francisco, CA, USA.
Lee E; Amgen Inc., Thousand Oaks, CA, 91320, USA.
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Źródło:
Drugs in R&D [Drugs R D] 2022 Jun; Vol. 22 (2), pp. 147-154. Date of Electronic Publication: 2022 Apr 12.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
MeSH Terms:
Healthy Volunteers*
Adult ; Area Under Curve ; Biological Availability ; Cross-Over Studies ; Humans ; Tablets ; Therapeutic Equivalency
Czasopismo naukowe
Tytuł:
Increasing Engagement of Women Veterans in Health Research.
Autorzy:
Chrystal JG; VA HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA. .
Dyer KE; VA HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Gammage CE; VA HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Klap RS; VA HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Carney DV; VA HSR&D Center for Innovation to Implementation (Ci2i), VA Palo Alto Health Care System, Menlo Park, CA, USA.
Frayne SM; VA HSR&D Center for Innovation to Implementation (Ci2i), VA Palo Alto Health Care System, Menlo Park, CA, USA.; Division of Primary Care and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Yano EM; VA HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.; Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Hamilton AB; VA HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
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Źródło:
Journal of general internal medicine [J Gen Intern Med] 2022 Apr; Vol. 37 (Suppl 1), pp. 42-49. Date of Electronic Publication: 2022 Mar 29.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Healthy Volunteers*/statistics & numerical data
Qualitative Research*
Veterans*
Women's Health*
Female ; Hospitals, Veterans ; Humans ; Registries ; United States ; United States Department of Veterans Affairs ; Veterans Health
Czasopismo naukowe
Tytuł:
Cerebral Cortex Changes in Basketball Players.
Autorzy:
Kim JH; Department of Anatomy, College of Medicine, Korea University, Seoul, Korea.
Park JW; Department of Anatomy, College of Medicine, Korea University, Seoul, Korea.
Tae WS; Brain Convergence Research Center, College of Medicine, Korea University, Seoul, Korea. .
Rhyu IJ; Department of Anatomy, College of Medicine, Korea University, Seoul, Korea.; Department of Biomedical Sciences, Brain Korea 21 FOUR, College of Medicine, Korea University, Seoul, Korea. .
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Źródło:
Journal of Korean medical science [J Korean Med Sci] 2022 Mar 21; Vol. 37 (11), pp. e86. Date of Electronic Publication: 2022 Mar 21.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
Healthy Volunteers*
Basketball/*physiology
Cerebral Cortex/*anatomy & histology
Gray Matter/*anatomy & histology
Motor Skills/*physiology
Space Perception/*physiology
Adult ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Students ; Universities ; Young Adult
Czasopismo naukowe
Tytuł:
Optical Coherence Tomography Angiography in Healthy Adult Subjects: Normative Values, Frequency, and Impact of Artifacts.
Autorzy:
Abu-Yaghi NE; Department of Special Surgery, Ophthalmology Division, School of Medicine, The University of Jordan, Amman, Jordan.
Obiedat AF; School of Medicine, The University of Jordan, Amman, Jordan.
AlNawaiseh TI; School of Medicine, The University of Jordan, Amman, Jordan.
Hamad AM; School of Medicine, The University of Jordan, Amman, Jordan.
Bani Ata BA; School of Medicine, The University of Jordan, Amman, Jordan.
Quzli AA; School of Medicine, The University of Jordan, Amman, Jordan.
AlRyalat SA; Department of Special Surgery, Ophthalmology Division, School of Medicine, The University of Jordan, Amman, Jordan.
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Źródło:
BioMed research international [Biomed Res Int] 2022 Mar 07; Vol. 2022, pp. 7286252. Date of Electronic Publication: 2022 Mar 07 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Healthy Volunteers*
Eye/*diagnostic imaging
Tomography, Optical Coherence/*methods
Adult ; Aged ; Artifacts ; Cross-Sectional Studies ; Female ; Humans ; Jordan ; Male ; Middle Aged ; Reference Values
Czasopismo naukowe
Tytuł:
Untargeted sequencing of circulating microRNAs in a healthy and diseased older population.
Autorzy:
Streese L; Department of Sport, Exercise and Health, Medical Faculty, University of Basel, Birsstrasse 320 B, 4052, Basel, Switzerland.
Demougin P; Transfaculty Research Platform Molecular and Cognitive Neurosciences, Life Sciences Training Facility, Biozentrum, University of Basel, Basel, Switzerland.
Iborra P; Computational and Systems Biology, Biozentrum, University of Basel, Basel, Switzerland.
Kanitz A; Computational and Systems Biology, Biozentrum, University of Basel, Basel, Switzerland.
Deiseroth A; Department of Sport, Exercise and Health, Medical Faculty, University of Basel, Birsstrasse 320 B, 4052, Basel, Switzerland.
Kröpfl JM; Department of Sport, Exercise and Health, Medical Faculty, University of Basel, Birsstrasse 320 B, 4052, Basel, Switzerland.
Schmidt-Trucksäss A; Department of Sport, Exercise and Health, Medical Faculty, University of Basel, Birsstrasse 320 B, 4052, Basel, Switzerland.
Zavolan M; Computational and Systems Biology, Biozentrum, University of Basel, Basel, Switzerland.
Hanssen H; Department of Sport, Exercise and Health, Medical Faculty, University of Basel, Birsstrasse 320 B, 4052, Basel, Switzerland. .
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Źródło:
Scientific reports [Sci Rep] 2022 Feb 22; Vol. 12 (1), pp. 2991. Date of Electronic Publication: 2022 Feb 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Healthy Volunteers*
Circulating MicroRNA/*genetics
Disease/*genetics
Gene Expression Profiling/*methods
Adaptation, Physiological/genetics ; Age Factors ; Cardiorespiratory Fitness ; Circulating MicroRNA/metabolism ; Circulating MicroRNA/physiology ; Cohort Studies ; Exercise/genetics ; Female ; Gene Expression/genetics ; Heart Disease Risk Factors ; Humans ; Male ; Sedentary Behavior
Czasopismo naukowe
Tytuł:
Effect of MIND diet intervention on cognitive performance and brain structure in healthy obese women: a randomized controlled trial.
Autorzy:
Arjmand G; Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Science, 71645-111, Shiraz, Iran.
Abbas-Zadeh M; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
Eftekhari MH; Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Science, 71645-111, Shiraz, Iran. h_.
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Źródło:
Scientific reports [Sci Rep] 2022 Feb 21; Vol. 12 (1), pp. 2871. Date of Electronic Publication: 2022 Feb 21.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Caloric Restriction*
Cognition*
Diet, Mediterranean*
Healthy Volunteers*
Brain/*diagnostic imaging
Brain/*pathology
Obesity/*pathology
Obesity/*psychology
Adult ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Neuropsychological Tests ; Time Factors
Czasopismo naukowe
Tytuł:
First-in-Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Pirepemat, a Cortical Enhancer, in Healthy Volunteers.
Autorzy:
Rein-Hedin E; CTC Clinical Trial Consultants AB, Uppsala, Sweden.; Department of Surgical Sciences, Plastic Surgery, Uppsala University, Uppsala, Sweden.
Sjöberg F; CTC Clinical Trial Consultants AB, Uppsala, Sweden.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Waters S; Integrative Research Laboratories Sweden AB, Gothenburg, Sweden.
Sonesson C; Integrative Research Laboratories Sweden AB, Gothenburg, Sweden.
Waters N; Integrative Research Laboratories Sweden AB, Gothenburg, Sweden.
Huss F; CTC Clinical Trial Consultants AB, Uppsala, Sweden.; Department of Surgical Sciences, Plastic Surgery, Uppsala University, Uppsala, Sweden.
Tedroff J; Integrative Research Laboratories Sweden AB, Gothenburg, Sweden.; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Dec; Vol. 10 (12), pp. 1485-1494. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Healthy Volunteers*
Area Under Curve ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Administration Schedule ; Humans ; Male
Czasopismo naukowe
Tytuł:
Quadriceps physiological response during the 1-min sit-to-stand test in people with severe COPD and healthy controls.
Autorzy:
Gephine S; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2725 Chemin Sainte-Foy, Quebec, QC, G1V 4G5, Canada.; Univ. Lille, Univ. Artois, Univ. Littoral Côte d'Opale, ULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Lille, F-59000, France.
Mucci P; Univ. Lille, Univ. Artois, Univ. Littoral Côte d'Opale, ULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, Lille, F-59000, France.
Bielmann M; Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Quebec, Canada.
Martin M; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2725 Chemin Sainte-Foy, Quebec, QC, G1V 4G5, Canada.
Bouyer L; Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Quebec, Canada.
Saey D; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2725 Chemin Sainte-Foy, Quebec, QC, G1V 4G5, Canada.
Maltais F; Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2725 Chemin Sainte-Foy, Quebec, QC, G1V 4G5, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 17; Vol. 12 (1), pp. 794. Date of Electronic Publication: 2022 Jan 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Healthy Volunteers*
Sitting Position*
Standing Position*
Exercise/*physiology
Exercise Test/*methods
Pulmonary Disease, Chronic Obstructive/*drug therapy
Pulmonary Disease, Chronic Obstructive/*physiopathology
Quadriceps Muscle/*physiopathology
Aged ; Female ; Humans ; Male ; Middle Aged ; Patient Acuity ; Time Factors
Czasopismo naukowe
Tytuł:
Multimodal deep learning applied to classify healthy and disease states of human microbiome.
Autorzy:
Lee SJ; Department of Computer Science, Hanyang University, Seoul, Korea.
Rho M; Department of Computer Science, Hanyang University, Seoul, Korea. .; Department of Biomedical Informatics, Hanyang University, Seoul, Korea. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 17; Vol. 12 (1), pp. 824. Date of Electronic Publication: 2022 Jan 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Deep Learning*
Healthy Volunteers*
Colorectal Neoplasms/*microbiology
Diabetes Mellitus, Type 2/*microbiology
Genome, Microbial/*genetics
Inflammatory Bowel Diseases/*microbiology
Liver Cirrhosis/*microbiology
Metagenome/*genetics
Metagenomics/*methods
Microbiota/*genetics
Colorectal Neoplasms/diagnosis ; Diabetes Mellitus, Type 2/diagnosis ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Liver Cirrhosis/diagnosis
Czasopismo naukowe
Tytuł:
Interocular symmetry of optical coherence tomography parameters in healthy children and adolescents.
Autorzy:
Song MY; Department of Ophthalmology, Kim's Eye Hospital, Seoul, Republic of Korea.
Hwang YH; Department of Ophthalmology, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon, 35015, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 13; Vol. 12 (1), pp. 653. Date of Electronic Publication: 2022 Jan 13.
Typ publikacji:
Journal Article
MeSH Terms:
Healthy Volunteers*
Tomography, Optical Coherence/*methods
Adolescent ; Child ; Child, Preschool ; Female ; Glaucoma/diagnostic imaging ; Humans ; Male ; Nerve Fibers ; Optic Disk ; Optic Nerve Diseases/diagnostic imaging ; Retina ; Retinal Ganglion Cells
Czasopismo naukowe
Tytuł:
The role of tricuspite annular plane systolic excursion as a marker of hypovolemia in healthy blood donor volunteers.
Autorzy:
Güllüpınar B; Izmir Bozyaka Training and Resarch Hospital, Department of Emergency Medicine, İzmir, TURKEY. Electronic address: .
Aytemiz F; Manisa City Hospital, Department of Cardiology, Manisa-İzmir, Turkey.
Karagöz A; Izmir Çiğli Training Hospital, Department of Emergency Medicine, İzmir, Turkey.
Tandon S; Parexel International Ltd., Chandigarh, India.
Sağlam C; Izmir Bozyaka Training and Resarch Hospital, Department of Emergency Medicine, İzmir, TURKEY.
Şehitoğlu Alpağut G; Buca Seyfi Demirsoy Training and Resarch Hospital, Department of Emergency Medicine, İzmir, Turkey.
Turhan A; Ege University Blood Bank, İzmir, Turkey.
Serin S; Buca Seyfi Demirsoy Training and Resarch Hospital, Department of Emergency Medicine, İzmir, Turkey.
Keskinoğlu P; Dokuz Eylul University Faculyt of Medicine, Department of Biostatistics and Medical Informatics, İzmir, TURKEY.
Ünlüer EE; Izmir Bozyaka Training and Resarch Hospital, Department of Emergency Medicine, İzmir, TURKEY.
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Źródło:
The American journal of emergency medicine [Am J Emerg Med] 2022 Jan; Vol. 51, pp. 320-324. Date of Electronic Publication: 2021 Oct 23.
Typ publikacji:
Journal Article
MeSH Terms:
Healthy Volunteers*
Hypovolemia/*diagnostic imaging
Systole/*physiology
Tricuspid Valve/*diagnostic imaging
Vena Cava, Inferior/*diagnostic imaging
Adult ; Biomarkers ; Blood Donors ; Cross-Sectional Studies ; Female ; Humans ; Hypovolemia/physiopathology ; Male ; Middle Aged ; Prospective Studies ; Ultrasonography ; Young Adult
Czasopismo naukowe
Tytuł:
Evaluation of the safety, tolerability, and pharmacokinetics of RO7049389 in healthy Chinese volunteers.
Autorzy:
Wu X; Phase I Clinical Research Center, Huashan Hospital, Fudan University, Shanghai, China.
Feng S; Pharmaceutical Sciences, Roche Innovation Center Shanghai, Shanghai, China.
Zhang J; Phase I Clinical Research Center, Huashan Hospital, Fudan University, Shanghai, China.
Zhang W; Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
Zhang Y; Pharmaceutical Sciences, Roche Innovation Center Shanghai, Shanghai, China.
Zhu M; I2O DTA, Roche Innovation Center Shanghai, Shanghai, China.
Triyatni M; Early Development Safety, Roche Pharma, Basel, Switzerland.
Zhao N; Biostatistics, Roche Pharma Product Development Shanghai, Shanghai, China.
Bo Q; I2O DTA, Roche Innovation Center Shanghai, Shanghai, China.
Jin Y; Pharmaceutical Sciences, Roche Innovation Center Shanghai, Shanghai, China.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2022 Jan; Vol. 15 (1), pp. 195-203. Date of Electronic Publication: 2021 Sep 25.
Typ publikacji:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Drug*
Drug Tolerance*
Healthy Volunteers*
Safety*
Antiviral Agents/*pharmacokinetics
Adolescent ; Adult ; China ; Double-Blind Method ; Female ; Hepatitis B, Chronic/drug therapy ; Humans ; Male ; Middle Aged ; Young Adult
Czasopismo naukowe
Tytuł:
Multi-Strain Probiotic Supplementation with a Product Containing Human-Native S. salivarius K12 in Healthy Adults Increases Oral S. salivarius .
Autorzy:
Cernioglo K; Department of Food Science and Technology, University of California Davis, Davis, CA 95616, USA.; Foods for Health Institute, University of California Davis, Davis, CA 95616, USA.
Kalanetra KM; Department of Food Science and Technology, University of California Davis, Davis, CA 95616, USA.
Meier A; Department of Food Science and Technology, University of California Davis, Davis, CA 95616, USA.; Foods for Health Institute, University of California Davis, Davis, CA 95616, USA.
Lewis ZT; Synbiotic Health, Inc., Lincoln, NE 68508, USA.
Underwood MA; Department of Pediatrics, University of California Davis Children's Hospital, Sacramento, CA 95817, USA.
Mills DA; Department of Food Science and Technology, University of California Davis, Davis, CA 95616, USA.; Foods for Health Institute, University of California Davis, Davis, CA 95616, USA.; Department of Viticulture and Enology, University of California Davis, Davis, CA 95616, USA.
Smilowitz JT; Department of Food Science and Technology, University of California Davis, Davis, CA 95616, USA.; Foods for Health Institute, University of California Davis, Davis, CA 95616, USA.
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Źródło:
Nutrients [Nutrients] 2021 Dec 08; Vol. 13 (12). Date of Electronic Publication: 2021 Dec 08.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Dietary Supplements*
Healthy Volunteers*
Streptococcus salivarius*
Probiotics/*administration & dosage
Probiotics/*pharmacology
Saliva/*microbiology
Adult ; Double-Blind Method ; Female ; Humans ; Male ; Recurrence ; Respiratory Tract Infections/prevention & control
Czasopismo naukowe
Tytuł:
The Beneficial Effects of Astaxanthin on Glucose Metabolism and Modified Low-Density Lipoprotein in Healthy Volunteers and Subjects with Prediabetes.
Autorzy:
Urakaze M; Internal Medicine, Diabetes Center, Kamiichi General Hospital, Kamiichi-machi 930-0391, Toyama Prefecture, Japan.
Kobashi C; Internal Medicine, Diabetes Center, Kamiichi General Hospital, Kamiichi-machi 930-0391, Toyama Prefecture, Japan.
Satou Y; Internal Medicine, Kamiichi General Hospital, Kamiichi-machi 930-0391, Toyama Prefecture, Japan.
Shigeta K; Internal Medicine, Kamiichi General Hospital, Kamiichi-machi 930-0391, Toyama Prefecture, Japan.
Toshima M; Vascular Surgery, Kamiichi General Hospital, Kamiichi-machi 930-0391, Toyama Prefecture, Japan.
Takagi M; Pharmacy, Kamiichi General Hospital, Kamiichi-machi 930-0391, Toyama Prefecture, Japan.
Takahashi J; Fuji Chemical Industries Co., Ltd., Kamiichi-machi 930-0355, Toyama Prefecture, Japan.
Nishida H; Fuji Chemical Industries Co., Ltd., Kamiichi-machi 930-0355, Toyama Prefecture, Japan.
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Źródło:
Nutrients [Nutrients] 2021 Dec 07; Vol. 13 (12). Date of Electronic Publication: 2021 Dec 07.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Dietary Supplements*
Healthy Volunteers*
Antioxidants/*administration & dosage
Antioxidants/*pharmacology
Atherosclerosis/*prevention & control
Diabetes Mellitus/*prevention & control
Glucose/*metabolism
Lipoproteins, LDL/*metabolism
Prediabetic State/*metabolism
Glycated Hemoglobin A/metabolism ; Insulin Resistance ; Intra-Abdominal Fat/metabolism ; Lipid Metabolism/drug effects ; Time Factors ; Xanthophylls/administration & dosage ; Xanthophylls/pharmacology
Czasopismo naukowe
Tytuł:
Randomized, Double-Blind, Controlled Study to Evaluate Safety and Pharmacokinetics of Single Ascending Doses of ASP5354, an Investigational Imaging Product, in Healthy Adult Volunteers.
Autorzy:
Murase T; Astellas Pharma Inc, Tokyo, Japan.
Takizawa M; Astellas Pharma Inc, Tokyo, Japan.
Galitz L; Labcorp Drug Development Inc., Daytona, Florida, USA.
Flach S; Labcorp Drub Development Inc, Madison, Wisconsin, USA.
Murray V; Labcorp Drug Development Inc, Leeds, UK.
Gufford B; Labcorp Drub Development Inc, Madison, Wisconsin, USA.
Suwa A; Rx+ Business Accelerator, Astellas Pharma Inc, Ibaraki, Japan.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Dec; Vol. 10 (12), pp. 1460-1468. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Healthy Volunteers*
Adult ; Area Under Curve ; Double-Blind Method ; Humans
Czasopismo naukowe
Tytuł:
A randomized phase-I pharmacokinetic trial comparing the potential biosimilar tocilizumab (QX003S) with the reference product (Actemra ) in Chinese healthy subjects.
Autorzy:
Zhang H; Phase I Clinical Research Center, The First Hospital of Jilin University, Jilin, China.
Li X; Phase I Clinical Research Center, The First Hospital of Jilin University, Jilin, China.
Liu J; Phase I Clinical Research Center, The First Hospital of Jilin University, Jilin, China.
Li C; Phase I Clinical Research Center, The First Hospital of Jilin University, Jilin, China.
Wu M; Phase I Clinical Research Center, The First Hospital of Jilin University, Jilin, China.
Zhu X; Phase I Clinical Research Center, The First Hospital of Jilin University, Jilin, China.
Sun J; Phase I Clinical Research Center, The First Hospital of Jilin University, Jilin, China.
Fang M; Qyuns Therapeutic Co. Ltd., Taizhou City, Jiangsu Province, China.
Ding Y; Phase I Clinical Research Center, The First Hospital of Jilin University, Jilin, China.
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Źródło:
Annals of medicine [Ann Med] 2021 Dec; Vol. 53 (1), pp. 375-383.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:
Healthy Volunteers*
Antibodies, Monoclonal, Humanized/*pharmacokinetics
Biosimilar Pharmaceuticals/*pharmacokinetics
Adult ; Biosimilar Pharmaceuticals/adverse effects ; China ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Pregnancy
Czasopismo naukowe
Tytuł:
Relationship between balance function and QOL in cancer survivors and healthy subjects.
Autorzy:
Morishita S; Department of Physical Therapy, School of Health Sciences, Fukushima Medical University, Fukushima, Japan.; Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.
Hirabayashi R; Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.
Tsubaki A; Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.
Aoki O; Faculty of Rehabilitation, Shijonawate Gakuen University, Osaka, Japan.
Fu JB; Department of Palliative, Rehabilitation & Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.
Onishi H; Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.
Tsuji T; Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan.
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Źródło:
Medicine [Medicine (Baltimore)] 2021 Nov 19; Vol. 100 (46), pp. e27822.
Typ publikacji:
Journal Article; Observational Study
MeSH Terms:
Healthy Volunteers*
Cancer Survivors/*psychology
Neoplasms/*psychology
Postural Balance/*physiology
Quality of Life/*psychology
Adult ; Female ; Hand Strength ; Humans ; Male ; Middle Aged ; Muscle Strength ; Neoplasms/therapy ; Prospective Studies ; Time and Motion Studies
Czasopismo naukowe
Tytuł:
Utility of diffusion MRI characteristics of cervical lymph nodes as disease classifier between patients with head and neck squamous cell carcinoma and healthy volunteers.
Autorzy:
Papoutsaki MV; Centre for Medical Imaging, University College London, London, UK.
Sidhu HS; Centre for Medical Imaging, University College London, London, UK.
Dikaios N; Centre for Vision, Speech and Signal Processing, University of Surrey, Guildford, UK.
Singh S; Centre for Medical Imaging, University College London, London, UK.
Atkinson D; Centre for Medical Imaging, University College London, London, UK.
Kanber B; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Beale T; Department of Radiology, University College London Hospital, London, UK.
Morley S; Department of Radiology, University College London Hospital, London, UK.
Forster M; Department of Oncology, University College London, Cancer Institute, London, UK.; Department of Oncology, University College London Hospital, London, UK.
Carnell D; Department of Oncology, University College London Hospital, London, UK.
Mendes R; Department of Oncology, University College London Hospital, London, UK.
Punwani S; Centre for Medical Imaging, University College London, London, UK.
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Źródło:
NMR in biomedicine [NMR Biomed] 2021 Nov; Vol. 34 (11), pp. e4587. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diffusion Magnetic Resonance Imaging*
Healthy Volunteers*
Head and Neck Neoplasms/*diagnostic imaging
Lymph Nodes/*diagnostic imaging
Neck/*diagnostic imaging
Squamous Cell Carcinoma of Head and Neck/*diagnostic imaging
Adult ; Aged ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Observer Variation ; ROC Curve
Czasopismo naukowe
Tytuł:
Age adjusted normative data for Video Head Impulse Test in healthy subjects.
Autorzy:
Treviño-González JL; Otolaryngology and Head and Neck Surgery Division, School of Medicine and University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico. Electronic address: .
Maldonado-Chapa F; Otolaryngology and Head and Neck Surgery Division, School of Medicine and University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
González-Cantú A; Research Department, Hospital Clínica Nova, Monterrey, Nuevo León, Mexico.
Soto-Galindo GA; Otolaryngology and Head and Neck Surgery Division, School of Medicine and University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
Ángel JAM; Otolaryngology and Head and Neck Surgery Division, School of Medicine and University Hospital 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
Pokaż więcej
Źródło:
American journal of otolaryngology [Am J Otolaryngol] 2021 Nov-Dec; Vol. 42 (6), pp. 103160. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji:
Journal Article
MeSH Terms:
Healthy Volunteers*
Video Recording*
Aging/*physiology
Head Impulse Test/*methods
Reflex, Vestibulo-Ocular/*physiology
Saccades/*physiology
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Dizziness/diagnosis ; Dizziness/etiology ; Dizziness/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Vertigo/diagnosis ; Vertigo/physiopathology ; Vestibular Diseases/complications ; Vestibular Diseases/diagnosis ; Vestibular Diseases/physiopathology ; Young Adult
Czasopismo naukowe

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