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Wyszukujesz frazę ""Heller JP"" wg kryterium: Autor


Tytuł:
Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice.
Autorzy:
Mamad O; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Heiland M; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Lindner AU; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Hill TDM; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Ronroy RM; Division of Population Health Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Rentrup K; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Sanz-Rodriguez A; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Langa E; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Heller JP; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; School of Biotechnology, Dublin City University, Dublin, Ireland.
Moreno O; CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), San Sebastián, Spain.
Llop J; CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), San Sebastián, Spain.
Bhattacharya A; Neuroscience, Janssen Pharmaceutical Research and Development, LLC, San Diego, CA, United States.
Palmer JA; Neuroscience, Janssen Pharmaceutical Research and Development, LLC, San Diego, CA, United States.
Ceusters M; Neuroscience, Janssen Pharmaceutical Research and Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Engel T; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Henshall DC; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
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Źródło:
Frontiers in pharmacology [Front Pharmacol] 2024 Jan 08; Vol. 14, pp. 1308478. Date of Electronic Publication: 2024 Jan 08 (Print Publication: 2023).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy.
Autorzy:
Brindley E; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Heiland M; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Mooney C; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; School of Computer Science, University College Dublin, Dublin, Ireland.
Diviney M; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Mamad O; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Hill TDM; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Yan Y; Interdisciplinary Nanoscience Centre (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.; Omiics ApS, Aarhus, Denmark.
Venø MT; Interdisciplinary Nanoscience Centre (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.; Omiics ApS, Aarhus, Denmark.
Reschke CR; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Batool A; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Langa E; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Sanz-Rodriguez A; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Heller JP; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; School of Biotechnology, Dublin City University, Dublin, Ireland.
Morris G; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.; Division of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.
Conboy K; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Kjems J; Interdisciplinary Nanoscience Centre (iNANO) and Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Brennan GP; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; School of Biomolecular and Biomedical Sciences, Conway Institute, University College Dublin, Dublin, Ireland.
Henshall DC; Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.; FutureNeuro SFI Research Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
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Źródło:
Frontiers in molecular neuroscience [Front Mol Neurosci] 2023 Sep 22; Vol. 16, pp. 1230942. Date of Electronic Publication: 2023 Sep 22 (Print Publication: 2023).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Human neutrophils communicate remotely via calcium-dependent glutamate-induced glutamate release.
Autorzy:
Kopach O; Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Sylantyev S; Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.; Rowett Institute, University of Aberdeen, Ashgrove Road West, Aberdeen AB25 2ZD, UK.
Bard L; Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Michaluk P; Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.; BRAINCITY, Laboratory of Neurobiology, Nencki Institute of Experimental Biology PAS, 3 Pasteur Street, 02-093 Warsaw, Poland.
Heller JP; Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.; School of Biotechnology, Dublin City University, Dublin 9, Ireland.
Gutierrez Del Arroyo A; Translational Medicine and Therapeutics, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
Ackland GL; Translational Medicine and Therapeutics, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
Gourine AV; Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Rusakov DA; Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
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Źródło:
IScience [iScience] 2023 Jun 28; Vol. 26 (7), pp. 107236. Date of Electronic Publication: 2023 Jun 28 (Print Publication: 2023).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Super-resolution imaging to reveal the nanostructure of tripartite synapses.
Autorzy:
Aleksejenko N; School of Biotechnology and National Institute for Cellular Biotechnology (NICB), Dublin City University, Glasnevin, Ireland.
Heller JP; School of Biotechnology and National Institute for Cellular Biotechnology (NICB), Dublin City University, Glasnevin, Ireland.; Queen Square Institute of Neurology, University College London, London, United Kingdom.
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Źródło:
Neuronal signaling [Neuronal Signal] 2021 Oct 14; Vol. 5 (4), pp. NS20210003. Date of Electronic Publication: 2021 Oct 14 (Print Publication: 2021).
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
Rapid recycling of glutamate transporters on the astroglial surface.
Autorzy:
Michaluk P; UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.; BRAINCITY, Laboratory of Neurobiology, Nencki Institute of Experimental Biology PAS, Warsaw, Poland.
Heller JP; UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.; School of Biotechnology and National Institute for Cellular Biotechnology (NICB), Dublin City University, Glasnevin, Ireland.
Rusakov DA; UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
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Źródło:
ELife [Elife] 2021 Apr 16; Vol. 10. Date of Electronic Publication: 2021 Apr 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytes/*metabolism
Excitatory Amino Acid Transporter 2/*metabolism
Animals ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł:
Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice.
Autorzy:
Campbell A; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, D02 YN77, Ireland.; FutureNeuro, The SFI Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, Ireland.
Morris G; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, D02 YN77, Ireland.; FutureNeuro, The SFI Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, Ireland.
Heller JP; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, D02 YN77, Ireland.; FutureNeuro, The SFI Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, Ireland.; Queen Square Institute of Neurology, University College London, London, UK.
Langa E; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, D02 YN77, Ireland.; FutureNeuro, The SFI Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, Ireland.
Brindley E; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, D02 YN77, Ireland.
Worm J; Roche Innovation Center Copenhagen, Copenhagen, Denmark.
Jensen MA; Roche Innovation Center Copenhagen, Copenhagen, Denmark.
Miller MT; F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Henshall DC; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, D02 YN77, Ireland. .; FutureNeuro, The SFI Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, Ireland. .; INFANT Research Centre, University College Cork, Cork, Ireland. .
Reschke CR; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin, D02 YN77, Ireland.; FutureNeuro, The SFI Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, Ireland.
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Źródło:
Scientific reports [Sci Rep] 2021 Jan 11; Vol. 11 (1), pp. 340. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antagomirs/*pharmacology
Kainic Acid/*pharmacology
MicroRNAs/*genetics
Seizures/*chemically induced
Seizures/*genetics
Animals ; Antagomirs/therapeutic use ; Brain/drug effects ; Brain/metabolism ; Dose-Response Relationship, Drug ; Male ; Mice ; Seizures/drug therapy
Czasopismo naukowe
Tytuł:
LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia.
Autorzy:
Henneberger C; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany. Electronic address: .
Bard L; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Panatier A; INSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France; Université de Bordeaux, 33000 Bordeaux, France; Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, 33000 Bordeaux, France.
Reynolds JP; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Kopach O; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Medvedev NI; Life Sciences, The Open University, Milton Keynes MK7 6AA, UK.
Minge D; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Herde MK; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Anders S; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Kraev I; Life Sciences, The Open University, Milton Keynes MK7 6AA, UK.
Heller JP; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Rama S; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Zheng K; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Jensen TP; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Sanchez-Romero I; Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria.
Jackson CJ; Research School of Chemistry, Australian National University, Acton, ACT 2601, Australia.
Janovjak H; Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria; EMBL Australia, Australian Regenerative Medicine Institute, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, VIC 3800, Australia.
Ottersen OP; Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway; Karolinska Institutet, 171 77 Stockholm, Sweden.
Nagelhus EA; Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
Oliet SHR; INSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France; Université de Bordeaux, 33000 Bordeaux, France.
Stewart MG; Life Sciences, The Open University, Milton Keynes MK7 6AA, UK. Electronic address: .
Nägerl UV; Université de Bordeaux, 33000 Bordeaux, France; Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, 33000 Bordeaux, France. Electronic address: .
Rusakov DA; UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address: .
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Źródło:
Neuron [Neuron] 2020 Dec 09; Vol. 108 (5), pp. 919-936.e11. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytes/*metabolism
Glutamic Acid/*metabolism
Long-Term Potentiation/*physiology
Synapses/*metabolism
Animals ; Astrocytes/ultrastructure ; Female ; Imaging, Three-Dimensional/methods ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Organ Culture Techniques ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Synapses/ultrastructure
Czasopismo naukowe
Tytuł:
Imaging tripartite synapses using super-resolution microscopy.
Autorzy:
Heller JP; UCL Queen Square Institute of Neurology, University College London, London, United Kingdom; FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: j.heller@ucl.ac.uk.
Odii T; UCL Queen Square Institute of Neurology, University College London, London, United Kingdom; Department of Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University Ndufu-Alike Ikwo, PMB 1010 Abakaliki, Nigeria.
Zheng K; UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Rusakov DA; UCL Queen Square Institute of Neurology, University College London, London, United Kingdom. Electronic address: .
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Źródło:
Methods (San Diego, Calif.) [Methods] 2020 Mar 01; Vol. 174, pp. 81-90. Date of Electronic Publication: 2019 May 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytes/*cytology
Brain/*diagnostic imaging
Imaging, Three-Dimensional/*methods
Microscopy, Fluorescence/*methods
Single Molecule Imaging/*methods
Synapses/*metabolism
Animals ; Astrocytes/metabolism ; Brain/metabolism ; Excitatory Amino Acid Transporter 2/metabolism ; Homer Scaffolding Proteins/metabolism ; Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional/instrumentation ; Immunohistochemistry ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy/methods ; Microscopy, Fluorescence/instrumentation ; Nerve Tissue Proteins/metabolism ; Single Molecule Imaging/instrumentation
Czasopismo naukowe
Tytuł:
Correction: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.
Autorzy:
Haq N
Schmidt-Hieber C
Sialana FJ
Ciani L
Heller JP
Stewart M
Bentley L
Wells S
Rodenburg RJ
Nolan PM
Forsythe E
Wu MC
Lubec G
Salinas PC
Häusser M
Beales PL
Christou-Savina S
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Źródło:
PLoS biology [PLoS Biol] 2019 Oct 08; Vol. 17 (10), pp. e3000520. Date of Electronic Publication: 2019 Oct 08 (Print Publication: 2019).
Typ publikacji:
Published Erratum
Tytuł:
Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.
Autorzy:
Haq N; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Schmidt-Hieber C; Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
Sialana FJ; Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria.
Ciani L; Department of Cell and Developmental Biology, University College London, London, United Kingdom.
Heller JP; Institute of Neurology, University College London, London, United Kingdom.
Stewart M; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire, United Kingdom.
Bentley L; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire, United Kingdom.
Wells S; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire, United Kingdom.
Rodenburg RJ; Radboud Center for Mitochondrial Medicine, Translational Metabolic Laboratory, Department of Pediatrics, Radboud University Medical Centre, Nijmegen, the Netherlands.
Nolan PM; MRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Oxfordshire, United Kingdom.
Forsythe E; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Wu MC; Neurodigitech, LLC, San Diego, California, United States of America.
Lubec G; Programme in Proteomics, Paracelsus Private Medical University, Salzburg, Austria.
Salinas P; Department of Cell and Developmental Biology, University College London, London, United Kingdom.
Häusser M; Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.
Beales PL; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Christou-Savina S; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
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Źródło:
PLoS biology [PLoS Biol] 2019 Sep 03; Vol. 17 (9), pp. e3000414. Date of Electronic Publication: 2019 Sep 03 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bardet-Biedl Syndrome/*pathology
Cytoskeletal Proteins/*metabolism
Dendritic Spines/*pathology
Animals ; Anxiety ; Bardet-Biedl Syndrome/metabolism ; Bardet-Biedl Syndrome/physiopathology ; Bardet-Biedl Syndrome/psychology ; Dentate Gyrus/physiopathology ; Disease Models, Animal ; Excitatory Postsynaptic Potentials ; Female ; Male ; Memory ; Mice ; Receptor, IGF Type 1/metabolism ; Synaptosomes/metabolism
Czasopismo naukowe
Tytuł:
The Nanoworld of the Tripartite Synapse: Insights from Super-Resolution Microscopy.
Autorzy:
Heller JP; UCL Institute of Neurology, University College London, London, United Kingdom.
Rusakov DA; UCL Institute of Neurology, University College London, London, United Kingdom.; Institute of Neuroscience, University of Nizhny Novgorod, Nizhny Novgorod, Russia.
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Źródło:
Frontiers in cellular neuroscience [Front Cell Neurosci] 2017 Nov 24; Vol. 11, pp. 374. Date of Electronic Publication: 2017 Nov 24 (Print Publication: 2017).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Probing nano-organization of astroglia with multi-color super-resolution microscopy.
Autorzy:
Heller JP; UCL Institute of Neurology, Department of Clinical and Experimental Epilepsy, Queen Square House, London WC1N 3BG, United Kingdom.
Michaluk P; UCL Institute of Neurology, Department of Clinical and Experimental Epilepsy, Queen Square House, London WC1N 3BG, United Kingdom.
Sugao K; UCL Institute of Neurology, Department of Clinical and Experimental Epilepsy, Queen Square House, London WC1N 3BG, United Kingdom.; Molecular Pathophysiology Research, Drug Research Division, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, 104-8356, Japan.
Rusakov DA; UCL Institute of Neurology, Department of Clinical and Experimental Epilepsy, Queen Square House, London WC1N 3BG, United Kingdom.
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Źródło:
Journal of neuroscience research [J Neurosci Res] 2017 Nov; Vol. 95 (11), pp. 2159-2171. Date of Electronic Publication: 2017 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes/*metabolism
Astrocytes/*ultrastructure
Microscopy, Fluorescence, Multiphoton/*methods
Nanotechnology/*methods
Animals ; Animals, Newborn ; Cells, Cultured ; Cerebral Cortex/cytology ; Cerebral Cortex/metabolism ; Cerebral Cortex/ultrastructure ; Female ; Glial Fibrillary Acidic Protein/metabolism ; Glial Fibrillary Acidic Protein/ultrastructure ; Male ; Microscopy/methods ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł:
Retinal ganglion cell neuroprotection by an angiotensin II blocker in an ex vivo retinal explant model.
Autorzy:
White AJ; Centre for Vision Research, Westmead Millennium Institute, University of Sydney, Australia Cambridge NIHR Biomedical Research Centre, UK .
Heller JP; John van Geest Centre for Brain Repair, University of Cambridge, UK.
Leung J; School of Medical Sciences, Discipline of Physiology, University of Sydney, Australia.
Tassoni A; John van Geest Centre for Brain Repair, University of Cambridge, UK.
Martin KR; John van Geest Centre for Brain Repair, University of Cambridge, UK Cambridge NIHR Biomedical Research Centre, UK Wellcome Trust - MRC Cambridge Stem Cell Institute, University of Cambridge, UK.
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Źródło:
Journal of the renin-angiotensin-aldosterone system : JRAAS [J Renin Angiotensin Aldosterone Syst] 2015 Dec; Vol. 16 (4), pp. 1193-201. Date of Electronic Publication: 2015 Jan 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Models, Biological*
Angiotensin II Type 1 Receptor Blockers/*pharmacology
Neuroprotection/*drug effects
Retinal Ganglion Cells/*cytology
Angiotensin II/pharmacology ; Animals ; Biphenyl Compounds/pharmacology ; Blotting, Western ; Cell Count ; Dendrites/drug effects ; Imaging, Three-Dimensional ; Irbesartan ; Male ; Membrane Glycoproteins/metabolism ; NADP/metabolism ; NADPH Oxidase 2 ; NADPH Oxidases/metabolism ; Protein Subunits/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Receptor, Angiotensin, Type 2/genetics ; Receptor, Angiotensin, Type 2/metabolism ; Staining and Labeling ; Tetrazoles/pharmacology
Czasopismo naukowe
Tytuł:
Morphological plasticity of astroglia: Understanding synaptic microenvironment.
Autorzy:
Heller JP; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, Queen Square, London, United Kingdom.
Rusakov DA; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, Queen Square, London, United Kingdom.
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Źródło:
Glia [Glia] 2015 Dec; Vol. 63 (12), pp. 2133-51. Date of Electronic Publication: 2015 Mar 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Astrocytes/*physiology
Neuronal Plasticity/*physiology
Synapses/*physiology
Animals ; Astrocytes/cytology ; Brain/cytology ; Brain/physiology ; Humans ; Neurons/physiology
Czasopismo naukowe
Tytuł:
A Method for the Isolation and Culture of Adult Rat Retinal Pigment Epithelial (RPE) Cells to Study Retinal Diseases.
Autorzy:
Heller JP; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge Cambridge, UK ; Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London London, UK.
Kwok JC; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge Cambridge, UK.
Vecino E; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge Cambridge, UK ; Department of Cellular Biology, University of the Basque Country Leioa, UPV/EHU, Bizkaia, Spain.
Martin KR; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge Cambridge, UK ; Department of Ophthalmology, NIHR Biomedical Research Centre and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge Cambridge, UK.
Fawcett JW; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge Cambridge, UK.
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Źródło:
Frontiers in cellular neuroscience [Front Cell Neurosci] 2015 Nov 20; Vol. 9, pp. 449. Date of Electronic Publication: 2015 Nov 20 (Print Publication: 2015).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Full length talin stimulates integrin activation and axon regeneration.
Autorzy:
Tan CL; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Kwok JC; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Heller JP; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Zhao R; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Eva R; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Fawcett JW; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK. Electronic address: .
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Źródło:
Molecular and cellular neurosciences [Mol Cell Neurosci] 2015 Sep; Vol. 68, pp. 1-8. Date of Electronic Publication: 2015 Mar 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Integrins/*metabolism
Neurons/*drug effects
Talin/*metabolism
Aggrecans/metabolism ; Animals ; Axons/physiology ; Cells, Cultured ; Ganglia, Spinal/cytology ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Integrins/genetics ; Laminin/metabolism ; Nerve Tissue Proteins/metabolism ; Neurons/cytology ; Neurons/metabolism ; Peptides/metabolism ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve/cytology ; Sciatic Nerve/metabolism ; Spinal Cord/cytology ; Spinal Cord/metabolism ; Talin/genetics ; Transfection
Czasopismo naukowe
Tytuł:
Influence of extracellular matrix components on the expression of integrins and regeneration of adult retinal ganglion cells.
Autorzy:
Vecino E; Dept. of Cell Biology and Histology, University of the Basque Country, UPV/EHU, Leioa, Vizcaya, Spain; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Heller JP; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Veiga-Crespo P; Dept. of Cell Biology and Histology, University of the Basque Country, UPV/EHU, Leioa, Vizcaya, Spain.
Martin KR; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom; Welcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Fawcett JW; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
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Źródło:
PloS one [PLoS One] 2015 May 27; Vol. 10 (5), pp. e0125250. Date of Electronic Publication: 2015 May 27 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Extracellular Matrix/*metabolism
Integrins/*metabolism
Retinal Ganglion Cells/*cytology
Retinal Ganglion Cells/*metabolism
Animals ; Cell Survival/physiology ; Female ; Immunohistochemistry ; Integrin alpha1/metabolism ; Integrin alpha5/metabolism ; Integrin beta1/metabolism ; Integrin beta3/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł:
Kinesin KIF4A transports integrin β1 in developing axons of cortical neurons.
Autorzy:
Heintz TG; John van Geest Centre for Brain Repair, Dept. Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Heller JP; John van Geest Centre for Brain Repair, Dept. Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Zhao R; John van Geest Centre for Brain Repair, Dept. Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK.
Caceres A; Laboratorio de Neurobiología Celular y Molecular, Instituto Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET), Friuli 2434, 5016 Córdoba, Argentina.
Eva R; John van Geest Centre for Brain Repair, Dept. Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK. Electronic address: .
Fawcett JW; John van Geest Centre for Brain Repair, Dept. Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, UK. Electronic address: .
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Źródło:
Molecular and cellular neurosciences [Mol Cell Neurosci] 2014 Nov; Vol. 63, pp. 60-71. Date of Electronic Publication: 2014 Sep 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Axonal Transport*
Axons/*metabolism
Integrin beta1/*metabolism
Kinesins/*metabolism
Animals ; Apoptosis ; Cerebral Cortex/cytology ; Cerebral Cortex/embryology ; Cerebral Cortex/metabolism ; Kinesins/genetics ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe

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