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Tytuł :
COVID-19 must catalyse changes to clinical development.
Autorzy :
MacKenzie R
Honig P
Sewards J
Goodwin R
Hellio MP
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Źródło :
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2020 Oct; Vol. 19 (10), pp. 653-654.
Typ publikacji :
Wiadomości
MeSH Terms :
Clinical Trials as Topic*
Health Equity*
Coronavirus Infections/*therapy
Pneumonia, Viral/*therapy
COVID-19 ; Coronavirus Infections/prevention & control ; Humans ; Information Dissemination ; Pandemics/prevention & control ; Patient Selection ; Pneumonia, Viral/prevention & control ; Viral Vaccines
Periodyk
Tytuł :
Plain radiography or magnetic resonance imaging (MRI): Which is better in assessing outcome in clinical trials of disease-modifying osteoarthritis drugs? Summary of a debate held at the World Congress of Osteoarthritis 2014.
Autorzy :
Eckstein F; Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Strubergasse 21, A5020 Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany. Electronic address: .
Le Graverand MP; Pfizer Global Medicines Development, Global Innovative Products Business, New York, NY.
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Źródło :
Seminars in arthritis and rheumatism [Semin Arthritis Rheum] 2015 Dec; Vol. 45 (3), pp. 251-6. Date of Electronic Publication: 2015 Jun 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Magnetic Resonance Imaging*
Antirheumatic Agents/*therapeutic use
Osteoarthritis/*drug therapy
Outcome Assessment, Health Care/*methods
Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/pathology ; Humans ; Osteoarthritis/diagnostic imaging ; Osteoarthritis/pathology ; Radiography ; Reproducibility of Results ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Changes in MR relaxation times of the meniscus with acute loading: an in vivo pilot study in knee osteoarthritis.
Autorzy :
Subburaj K; Musculoskeletal and Quantitative Imaging Research Group Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Souza RB
Wyman BT
Le Graverand-Gastineau MP
Li X
Link TM
Majumdar S
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Źródło :
Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2015 Feb; Vol. 41 (2), pp. 536-43. Date of Electronic Publication: 2013 Dec 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Magnetic Resonance Imaging/*methods
Menisci, Tibial/*physiopathology
Osteoarthritis, Knee/*physiopathology
Adult ; Aged ; Case-Control Studies ; Female ; Humans ; Middle Aged ; Pilot Projects ; Prospective Studies ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.
Autorzy :
Malfait AM; Department of Biochemistry/ Internal Medicine, Rush University Medical Center, Chicago, Illinois 60612, USA. />Seymour AB
Gao F
Tortorella MD
Le Graverand-Gastineau MP
Wood LS
Doherty M
Doherty S
Zhang W
Arden NK
Vaughn FL
Leaverton PE
Spector TD
Hart DJ
Maciewicz RA
Muir KR
Das R
Sorge RE
Sotocinal SG
Schorscher-Petcu A
Valdes AM
Mogil JS
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Źródło :
Annals of the rheumatic diseases [Ann Rheum Dis] 2012 Jun; Vol. 71 (6), pp. 1042-8. Date of Electronic Publication: 2012 Mar 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthralgia/*genetics
Osteoarthritis, Knee/*genetics
Proprotein Convertases/*genetics
Serine Endopeptidases/*genetics
Aged ; Animals ; Arthralgia/diagnostic imaging ; Arthralgia/epidemiology ; Female ; Genetic Predisposition to Disease/epidemiology ; Genetic Predisposition to Disease/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/epidemiology ; Phenotype ; Radiography ; Risk Factors
Czasopismo naukowe
Tytuł :
Determining clinically important changes in range of motion in patients with Dupuytren's Contracture: secondary analysis of the randomized, double-blind, placebo-controlled CORD I study.
Autorzy :
Witthaut J; Hand Surgery Department, University Hospital, Uppsala, Sweden. />Bushmakin AG
Gerber RA
Cappelleri JC
Le Graverand-Gastineau MP
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Źródło :
Clinical drug investigation [Clin Drug Investig] 2011 Nov 01; Vol. 31 (11), pp. 791-8.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Clostridium histolyticum*
Dupuytren Contracture/*therapy
Microbial Collagenase/*therapeutic use
Range of Motion, Articular/*physiology
Aged ; Arthrometry, Articular ; Disease Progression ; Double-Blind Method ; Dupuytren Contracture/pathology ; Dupuytren Contracture/physiopathology ; Female ; Fingers/pathology ; Humans ; Male ; Middle Aged ; Patient Satisfaction ; Placebos ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Osteoarthritis of the knee at 3.0 T: comparison of a quantitative and a semi-quantitative score for the assessment of the extent of cartilage lesion and bone marrow edema pattern in a 24-month longitudinal study.
Autorzy :
Stahl R; Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107-0946, USA. />Jain SK
Lutz J
Wyman BT
Le Graverand-Gastineau MP
Vignon E
Majumdar S
Link TM
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Źródło :
Skeletal radiology [Skeletal Radiol] 2011 Oct; Vol. 40 (10), pp. 1315-27. Date of Electronic Publication: 2011 Apr 09.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Magnetic Resonance Imaging*
Bone Marrow/*pathology
Osteoarthritis, Knee/*pathology
Cartilage, Articular/pathology ; Disease Progression ; Edema/pathology ; Feasibility Studies ; Female ; Humans ; Longitudinal Studies ; Middle Aged ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
The relationship between prevalent medial meniscal intrasubstance signal changes and incident medial meniscal tears in women over a 1-year period assessed with 3.0 T MRI.
Autorzy :
Crema MD; Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, 820 Harrison Avenue, FGH Building, Boston, MA 02118, USA. />Hunter DJ
Roemer FW
Li L
Marra MD
Nogueira-Barbosa MH
Le Graverand MP
Wyman BT
Guermazi A
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Źródło :
Skeletal radiology [Skeletal Radiol] 2011 Aug; Vol. 40 (8), pp. 1017-23. Date of Electronic Publication: 2011 May 08.
Typ publikacji :
Journal Article
MeSH Terms :
Magnetic Resonance Imaging/*methods
Menisci, Tibial/*pathology
Osteoarthritis, Knee/*pathology
Disease Progression ; Female ; Humans ; Incidence ; Longitudinal Studies ; Middle Aged ; Osteoarthritis, Knee/drug therapy ; Pain Measurement ; Prevalence ; Reproducibility of Results ; Severity of Illness Index ; Time Factors
Czasopismo naukowe
Tytuł :
Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis.
Autorzy :
Eckstein F; Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria. />Le Graverand MP
Charles HC
Hunter DJ
Kraus VB
Sunyer T
Nemirovskyi O
Wyman BT
Buck R
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Corporate Authors :
A9001140, investigators
Źródło :
Annals of the rheumatic diseases [Ann Rheum Dis] 2011 Jul; Vol. 70 (7), pp. 1223-30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cartilage, Articular/*pathology
Osteoarthritis, Knee/*pathology
Aged ; Biomarkers/metabolism ; Cartilage, Articular/diagnostic imaging ; Disease Progression ; Epidemiologic Methods ; Female ; Humans ; Knee Joint/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Middle Aged ; Osteoarthritis, Knee/diagnosis ; Osteoarthritis, Knee/diagnostic imaging ; Prognosis ; Radiography
Czasopismo naukowe
Tytuł :
The efficacy and safety of fasciectomy and fasciotomy for Dupuytren's contracture in European patients: a structured review of published studies.
Autorzy :
Crean SM; United BioSource Corporation, Lexington, MA 02420, USA. />Gerber RA
Le Graverand MP
Boyd DM
Cappelleri JC
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Źródło :
The Journal of hand surgery, European volume [J Hand Surg Eur Vol] 2011 Jun; Vol. 36 (5), pp. 396-407. Date of Electronic Publication: 2011 Mar 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Fasciotomy*
Outcome and Process Assessment, Health Care*
Dupuytren Contracture/*surgery
Europe ; Humans ; Postoperative Complications
Czasopismo naukowe
Tytuł :
Rates of change and sensitivity to change in cartilage morphology in healthy knees and in knees with mild, moderate, and end-stage radiographic osteoarthritis: results from 831 participants from the Osteoarthritis Initiative.
Autorzy :
Eckstein F; Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria. />Nevitt M
Gimona A
Picha K
Lee JH
Davies RY
Dreher D
Benichou O
Le Graverand MP
Hudelmaier M
Maschek S
Wirth W
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Corporate Authors :
Osteoarthritis Initiative Investigators Group
Źródło :
Arthritis care & research [Arthritis Care Res (Hoboken)] 2011 Mar; Vol. 63 (3), pp. 311-9.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Magnetic Resonance Imaging*
Cartilage, Articular/*pathology
Knee Joint/*diagnostic imaging
Knee Joint/*pathology
Osteoarthritis, Knee/*diagnostic imaging
Aged ; Aged, 80 and over ; Case-Control Studies ; Disease Progression ; Europe ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Predictive Value of Tests ; Radiography ; Severity of Illness Index ; Time Factors ; United States
Czasopismo naukowe
Tytuł :
Alignment of the medial tibial plateau affects the rate of joint space narrowing in the osteoarthritic knee.
Autorzy :
Vignon E; Université Claude Bernard Lyon 1, Lyon, France. />Brandt KD
Mercier C
Hochberg M
Hunter D
Mazzuca S
Powell K
Wyman B
Le Graverand MP
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Źródło :
Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2010 Nov; Vol. 18 (11), pp. 1436-40. Date of Electronic Publication: 2010 Sep 08.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Knee Joint/*diagnostic imaging
Osteoarthritis, Knee/*diagnostic imaging
Tibia/*diagnostic imaging
Aged ; Disease Progression ; Epidemiologic Methods ; Female ; Humans ; Knee Joint/pathology ; Male ; Middle Aged ; Osteoarthritis, Knee/pathology ; Radiography
Czasopismo naukowe
Tytuł :
Comparison of radiographic joint space width with magnetic resonance imaging cartilage morphometry: analysis of longitudinal data from the Osteoarthritis Initiative.
Autorzy :
Duryea J; Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. />Neumann G
Niu J
Totterman S
Tamez J
Dabrowski C
Le Graverand MP
Luchi M
Beals CR
Hunter DJ
Pokaż więcej
Źródło :
Arthritis care & research [Arthritis Care Res (Hoboken)] 2010 Jul; Vol. 62 (7), pp. 932-7.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Image Interpretation, Computer-Assisted*
Magnetic Resonance Imaging*
Menisci, Tibial/*diagnostic imaging
Menisci, Tibial/*pathology
Osteoarthritis, Knee/*diagnostic imaging
Osteoarthritis, Knee/*pathology
Aged ; Anthropometry ; Female ; Femur/diagnostic imaging ; Femur/pathology ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Radiography ; Tibia/diagnostic imaging ; Tibia/pathology
Czasopismo naukowe
Tytuł :
Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets.
Autorzy :
Le Graverand-Gastineau MP; Pfizer Global Research and Development, New London, CT, USA.
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Źródło :
Current drug targets [Curr Drug Targets] 2010 May; Vol. 11 (5), pp. 528-35.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Anabolic Agents/*therapeutic use
Drug Delivery Systems/*methods
Metabolism/*drug effects
Osteoarthritis/*drug therapy
Animals ; Clinical Trials as Topic ; Humans
Czasopismo naukowe
Tytuł :
A three-dimensional quantitative method to measure meniscus shape, position, and signal intensity using MR images: a pilot study and preliminary results in knee osteoarthritis.
Autorzy :
Wirth W; Paracelsus Medical University, Salzburg, Austria. />Frobell RB
Souza RB
Li X
Wyman BT
Le Graverand MP
Link TM
Majumdar S
Eckstein F
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Źródło :
Magnetic resonance in medicine [Magn Reson Med] 2010 May; Vol. 63 (5), pp. 1162-71.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
Image Enhancement/*methods
Image Interpretation, Computer-Assisted/*methods
Imaging, Three-Dimensional/*methods
Magnetic Resonance Imaging/*methods
Menisci, Tibial/*pathology
Osteoarthritis, Knee/*pathology
Adult ; Female ; Humans ; Male ; Pilot Projects ; Reproducibility of Results ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee.
Autorzy :
Buck RJ; StatAnswers Consulting LLC, San Diego, California 92122, USA. />Wyman BT
Le Graverand MP
Wirth W
Eckstein F
Pokaż więcej
Corporate Authors :
A9001140 Investigators
Źródło :
Magnetic resonance in medicine [Magn Reson Med] 2010 Mar; Vol. 63 (3), pp. 680-90.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
Cartilage, Articular/*pathology
Image Interpretation, Computer-Assisted/*methods
Knee Joint/*pathology
Osteoarthritis, Knee/*pathology
Female ; Humans ; Image Enhancement/methods ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity
Czasopismo naukowe

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