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Wyszukujesz frazę ""Hematopoietic Stem Cells"" wg kryterium: Temat


Tytuł :
Chaperone-mediated autophagy sustains haematopoietic stem-cell function.
Autorzy :
Dong S; Department of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY, USA.
Wang Q; Department of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Kao YR; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Diaz A; Department of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY, USA.
Tasset I; Department of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY, USA.
Kaushik S; Department of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.; Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY, USA.
Thiruthuvanathan V; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Zintiridou A; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Nieves E; Department of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA.
Dzieciatkowska M; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Reisz JA; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Gavathiotis E; Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY, USA.; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.; Department of Medicine (Oncology), Albert Einstein College of Medicine, New York, NY, USA.; Ruth L. and David S. Gottesman Institute for Stem Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA.
Will B; Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY, USA. .; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA. .; Department of Medicine (Oncology), Albert Einstein College of Medicine, New York, NY, USA. .; Ruth L. and David S. Gottesman Institute for Stem Cell Biology, Albert Einstein College of Medicine, New York, NY, USA. .
Cuervo AM; Department of Development and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA. .; Institute for Aging Studies, Albert Einstein College of Medicine, New York, NY, USA. .
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Źródło :
Nature [Nature] 2021 Mar; Vol. 591 (7848), pp. 117-123. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chaperone-Mediated Autophagy/*physiology
Hematopoietic Stem Cells/*physiology
Adult ; Aged ; Aging ; Animals ; Cell Self Renewal ; Cells, Cultured ; Chaperone-Mediated Autophagy/drug effects ; Chaperone-Mediated Autophagy/genetics ; Energy Metabolism ; Female ; Glycolysis ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/drug effects ; Hematopoietic Stem Cells/metabolism ; Humans ; Linoleic Acid/metabolism ; Male ; Mice ; Middle Aged ; Multiple Myeloma/pathology ; Rejuvenation ; Young Adult
Czasopismo naukowe
Tytuł :
Quercetin induces autophagy in myelodysplastic bone marrow including hematopoietic stem/progenitor compartment.
Autorzy :
Daw S; Stem Cell Research and Application Unit, Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
Law S; Stem Cell Research and Application Unit, Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Feb; Vol. 36 (2), pp. 149-167. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*therapeutic use
Autophagy/*drug effects
Hematopoiesis/*drug effects
Hematopoietic Stem Cells/*drug effects
Myelodysplastic Syndromes/*drug therapy
Quercetin/*therapeutic use
Animals ; Apoptosis/drug effects ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/metabolism ; Bone Marrow Cells/pathology ; Cell Movement/drug effects ; Disease Models, Animal ; Down-Regulation ; Female ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/pathology ; Humans ; Male ; Mice ; Myelodysplastic Syndromes/metabolism ; Myelodysplastic Syndromes/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Gata2 -77 enhancer regulates adult hematopoietic stem cell survival.
Autorzy :
You X; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin-Madison Blood Research Program, Madison, WI, USA.
Chang YI; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.; Institute of Physiology, National Yang-Ming University, Taipei City, Taiwan.
Kong G; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.; National Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P. R. China.
Ranheim EA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Zhou Y; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.; University of Wisconsin-Madison Blood Research Program, Madison, WI, USA.
Johnson KD; University of Wisconsin-Madison Blood Research Program, Madison, WI, USA.; Carbone Cancer Center, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Mehta C; University of Wisconsin-Madison Blood Research Program, Madison, WI, USA.; Carbone Cancer Center, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Bresnick EH; University of Wisconsin-Madison Blood Research Program, Madison, WI, USA.; Carbone Cancer Center, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Zhang J; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA. .; University of Wisconsin-Madison Blood Research Program, Madison, WI, USA. .
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Źródło :
Leukemia [Leukemia] 2021 Mar; Vol. 35 (3), pp. 901-905. Date of Electronic Publication: 2020 Jun 27.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural
MeSH Terms :
Enhancer Elements, Genetic*
Gene Expression Regulation, Neoplastic*
GATA2 Transcription Factor/*physiology
Hematopoietic Stem Cells/*cytology
Leukemia, Experimental/*pathology
Animals ; GATA2 Transcription Factor/genetics ; Hematopoietic Stem Cells/metabolism ; Leukemia, Experimental/genetics ; Leukemia, Experimental/metabolism ; Mice ; Mice, Knockout
Raport
Tytuł :
Fusion of the CRM1 nuclear export receptor to AF10 causes leukemia and transcriptional activation of HOXA genes.
Autorzy :
Aumann WK; Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA.; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Heath JL; Department of Pediatrics, Biochemistry, University of Vermont; University of Vermont Children's Hospital; Vermont Cancer Center, Burlington, VT, USA.
Conway AE; National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, Durham, NC, USA.
Sze SK; Maine Children's Cancer Program, Scarborough, ME, USA.
Gupta VK; Department of Pediatrics, Division of Pediatric Hematology-Oncology, Duke University Medical Center, Durham, NC, USA.
Kazi RR; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Tope DR; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Wechsler DS; Aflac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA. .; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. .
Lavau CP; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA. .
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Źródło :
Leukemia [Leukemia] 2021 Mar; Vol. 35 (3), pp. 876-880. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptional Activation*
Hematopoietic Stem Cells/*pathology
Homeodomain Proteins/*genetics
Karyopherins/*metabolism
Leukemia, Experimental/*pathology
Oncogene Proteins, Fusion/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Transcription Factors/*metabolism
Active Transport, Cell Nucleus ; Animals ; Apoptosis ; Cell Proliferation ; Cells, Cultured ; Gene Expression Regulation, Leukemic ; Hematopoietic Stem Cells/metabolism ; Homeodomain Proteins/metabolism ; Karyopherins/genetics ; Leukemia, Experimental/etiology ; Leukemia, Experimental/metabolism ; Mice ; Oncogene Proteins, Fusion/genetics ; Receptors, Cytoplasmic and Nuclear/genetics ; Transcription Factors/genetics
Raport
Tytuł :
LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
Autorzy :
Höpner SS; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Raykova A; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Radpour R; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Amrein MA; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Koller D; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Baerlocher GM; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Riether C; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, University of Bern, Bern, Switzerland.
Ochsenbein AF; Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. .; Department for BioMedical Research, University of Bern, Bern, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 16; Vol. 12 (1), pp. 1065. Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*/drug effects
Cell Self Renewal*/drug effects
Cell Self Renewal*/genetics
Hematopoietic Stem Cells/*metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*pathology
Lymphotoxin beta Receptor/*metabolism
Neoplastic Stem Cells/*pathology
Tumor Necrosis Factor Ligand Superfamily Member 14/*metabolism
Animals ; Antigens, CD34/metabolism ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Proliferation/drug effects ; DNA Damage ; Fluorouracil/pharmacology ; Gene Expression Regulation, Leukemic/drug effects ; Hematopoietic Stem Cells/drug effects ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.
Autorzy :
Muskens IS; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Li S; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Jackson T; Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK.
Elliot N; Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK.
Hansen HM; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Myint SS; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Pandey P; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Schraw JM; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX, USA.
Roy R; Computational Biology and Informatics, University of California San Francisco, San Francisco, CA, USA.
Anguiano J; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Goudevenou K; Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK.
Siegmund KD; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Lupo PJ; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX, USA.
de Bruijn MFTR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Walsh KM; Department of Neurosurgery, Duke University, Durham, NC, USA.; Department of Pediatrics, Duke University, Durham, NC, USA.
Vyas P; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Ma X; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Roy A; Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK.
Roberts I; Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK.
Wiemels JL; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
de Smith AJ; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA. .; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 05; Vol. 12 (1), pp. 821. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Core Binding Factor Alpha 2 Subunit/*genetics
Down Syndrome/*genetics
Hematopoiesis/*genetics
Hematopoietic Stem Cells/*metabolism
Proto-Oncogene Protein c-fli-1/*genetics
Case-Control Studies ; Core Binding Factor Alpha 2 Subunit/metabolism ; CpG Islands ; DNA Methylation ; Down Syndrome/metabolism ; Down Syndrome/pathology ; Female ; Fetus ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Genome, Human ; Genome-Wide Association Study ; Hematopoietic Stem Cells/pathology ; Humans ; Infant, Newborn ; Liver/metabolism ; Liver/pathology ; Male ; Promoter Regions, Genetic ; Proto-Oncogene Protein c-fli-1/metabolism
Czasopismo naukowe
Tytuł :
Definition of a small core transcriptional circuit regulated by AML1-ETO.
Autorzy :
Stengel KR; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: .
Ellis JD; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Spielman CL; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Bomber ML; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Hiebert SW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Feb 04; Vol. 81 (3), pp. 530-545.e5. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Core Binding Factor Alpha 2 Subunit/*metabolism
Hematopoietic Stem Cells/*metabolism
Leukemia, Myeloid, Acute/*metabolism
Neoplastic Stem Cells/*metabolism
Oncogene Proteins, Fusion/*metabolism
RNA, Neoplasm/*biosynthesis
RUNX1 Translocation Partner 1 Protein/*metabolism
Acetylation ; Binding Sites ; Binding, Competitive ; Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation ; Cell Self Renewal ; Core Binding Factor Alpha 2 Subunit/genetics ; Fetal Blood/cytology ; Gene Expression Regulation, Leukemic ; Gene Regulatory Networks ; HEK293 Cells ; Hematopoietic Stem Cells/pathology ; Histones/metabolism ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Neoplastic Stem Cells/pathology ; Oncogene Proteins, Fusion/genetics ; Protein Binding ; Proteolysis ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; RNA, Neoplasm/genetics ; RUNX1 Translocation Partner 1 Protein/genetics ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Time Factors ; Transcriptome
Czasopismo naukowe
Tytuł :
Method for the Generation of Induced Hematopoietic Stem Cells.
Autorzy :
Olender L; The Shraga Segal Department for Microbiology, Immunology, and Genetics, Faculty of Health Sciences, National Institute for Biotechnology in the Negev, The Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Levy K; The Shraga Segal Department for Microbiology, Immunology, and Genetics, Faculty of Health Sciences, National Institute for Biotechnology in the Negev, The Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Gazit R; The Shraga Segal Department for Microbiology, Immunology, and Genetics, Faculty of Health Sciences, National Institute for Biotechnology in the Negev, The Ben-Gurion University of the Negev, Beer-Sheva, Israel. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2185, pp. 399-410.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Reprogramming*
Cellular Reprogramming Techniques*
Hematopoietic Stem Cells*/cytology
Hematopoietic Stem Cells*/metabolism
Induced Pluripotent Stem Cells*/cytology
Induced Pluripotent Stem Cells*/metabolism
Animals ; HEK293 Cells ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Analysis and Isolation of Mouse Leukemic Stem Cells.
Autorzy :
Dong F; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Bai H; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Ema H; Department of Regenerative Medicine, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2185, pp. 51-63.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Flow Cytometry*
Hematopoietic Stem Cells*/metabolism
Hematopoietic Stem Cells*/pathology
Leukemia*/metabolism
Leukemia*/pathology
Neoplastic Stem Cells*/metabolism
Neoplastic Stem Cells*/pathology
Animals ; Mice
Czasopismo naukowe
Tytuł :
Trained Immunity and Cardiometabolic Disease: The Role of Bone Marrow.
Autorzy :
Mitroulis I; Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Germany (I.M., T.C.).; National Center for Tumor Diseases (NCT), Partner Site Dresden, German Cancer Research Center (DKFZ), Heidelberg, Germany (I.M.).; First Department of Internal Medicine, Department of Haematology and Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece (I.M.).
Hajishengallis G; Laboratory of Innate Immunity and Inflammation, Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia (G.H.).
Chavakis T; Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Germany (I.M., T.C.).; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, United Kingdom (T.C.).
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Jan; Vol. 41 (1), pp. 48-54. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Immunity, Innate*
Immunologic Memory*
Bone Marrow/*immunology
Cardiovascular Diseases/*immunology
Hematopoietic Stem Cells/*immunology
Metabolic Diseases/*immunology
Bone Marrow/metabolism ; Bone Marrow/pathology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/pathology ; Humans ; Metabolic Diseases/metabolism ; Metabolic Diseases/pathology ; Myelopoiesis
Czasopismo naukowe
Tytuł :
Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells.
Autorzy :
Khavinson VK; Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.; Group of Peptide Regulation and Aging, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Linkova NS; Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia. .; Department of Therapy, Geriatrics, and Anti-Aging Medicine, Academy of Postgraduate Education under Federal Research Clinical Center of Federal Medical-Biological Agency of Russia, Moscow, Russia. .
Kvetnoy IM; Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
Polyakova VO; Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
Drobintseva AO; Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
Kvetnaia TV; Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
Ivko OM; Department of Biogerontology, St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
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Źródło :
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2020 Nov; Vol. 170 (1), pp. 118-122. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation/*drug effects
Hematopoietic Stem Cells/*drug effects
Hematopoietic Stem Cells/*physiology
Thymus Hormones/*pharmacology
CD28 Antigens/genetics ; CD28 Antigens/metabolism ; COVID-19/immunology ; COVID-19/pathology ; Cell Differentiation/genetics ; Cells, Cultured ; Fetal Blood/cytology ; Gene Expression Regulation/drug effects ; Hematopoietic Stem Cells/pathology ; Humans ; Hyaluronan Receptors/genetics ; Hyaluronan Receptors/metabolism ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; SARS-CoV-2/immunology ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism ; T-Lymphocytes/physiology ; Thymus Hormones/physiology
Czasopismo naukowe
Tytuł :
Targeting Abnormal Hematopoietic Stem Cells in Chronic Myeloid Leukemia and Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms.
Autorzy :
Yung Y; Division of Haematology, Medical Oncology and Haemopoietic Stem Cell transplantation, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Lee E; Division of Haematology, Medical Oncology and Haemopoietic Stem Cell transplantation, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Chu HT; Division of Haematology, Medical Oncology and Haemopoietic Stem Cell transplantation, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Yip PK; Division of Haematology, Medical Oncology and Haemopoietic Stem Cell transplantation, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Gill H; Division of Haematology, Medical Oncology and Haemopoietic Stem Cell transplantation, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 11; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Disease Susceptibility*
Hematopoietic Stem Cells/*metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*etiology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*therapy
Myeloproliferative Disorders/*etiology
Myeloproliferative Disorders/*therapy
Neoplastic Stem Cells/*metabolism
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Autophagy ; Biomarkers, Tumor ; Cell Survival/drug effects ; Cell Transformation, Neoplastic/genetics ; Combined Modality Therapy ; Genetic Predisposition to Disease ; Hematopoietic Stem Cells/drug effects ; Hematopoietic Stem Cells/pathology ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Molecular Targeted Therapy ; Myeloproliferative Disorders/pathology ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology ; Philadelphia Chromosome ; Signal Transduction/drug effects ; Stem Cell Niche ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Isolation, Culture, and Manipulation of Human Cord Blood Progenitors.
Autorzy :
Prieto C; VIB Center for Cancer Biology, Leuven, Belgium. .; KU Leuven Center for Human Genetics, Leuven, Belgium. .
Romero-Moya D; Department of Anatomy, University of California, San Francisco, CA, USA. .
Montes R; GENYO Centre for Genomics and Oncological Research, Pfizer-Universidad de Granada - Junta de Andalucia. PTS Granada, Granada, Spain. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2185, pp. 281-298.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Culture Techniques*
Cryopreservation*
Fetal Blood*/cytology
Fetal Blood*/metabolism
Flow Cytometry*
Hematopoietic Stem Cells*/cytology
Hematopoietic Stem Cells*/metabolism
Humans
Czasopismo naukowe
Tytuł :
Nociceptive nerves regulate haematopoietic stem cell mobilization.
Autorzy :
Gao X; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Zhang D; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Xu C; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Li H; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA.; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA.
Caron KM; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Frenette PS; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY, USA. .; Department of Cell Biology, Albert Einstein College of Medicine, New York, NY, USA. .; Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA. .
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Źródło :
Nature [Nature] 2021 Jan; Vol. 589 (7843), pp. 591-596. Date of Electronic Publication: 2020 Dec 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Autonomic Pathways*/drug effects
Cell Movement*/drug effects
Hematopoietic Stem Cells/*cytology
Nociception/*physiology
Nociceptors/*physiology
Sympathetic Nervous System/*cytology
Adenylyl Cyclases/metabolism ; Animals ; Calcitonin Gene-Related Peptide/metabolism ; Calcitonin Receptor-Like Protein/metabolism ; Capsaicin/pharmacology ; Cyclic AMP/metabolism ; Female ; GTP-Binding Protein alpha Subunits, Gs/metabolism ; Granulocyte Colony-Stimulating Factor/metabolism ; Hematopoietic Stem Cells/drug effects ; Hematopoietic Stem Cells/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Nociception/drug effects ; Nociceptors/drug effects ; Receptor Activity-Modifying Protein 1/metabolism ; Signal Transduction/drug effects ; Stem Cell Niche ; Sympathetic Nervous System/drug effects
Czasopismo naukowe
Tytuł :
Ex Vivo Expansion of Adult Hematopoietic Stem and Progenitor Cells with Valproic Acid.
Autorzy :
Papa L; Division of Hematology/Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
Djedaini M; Division of Hematology/Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kintali M; Division of Hematology/Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Schaniel C; Department of Pharmacological Sciences, Mount Sinai Institute for System Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Black Family Stem Cell Institute, Mount Sinai Institute for System Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hoffman R; Division of Hematology/Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2185, pp. 267-280.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Culture Techniques*
Adult Stem Cells/*metabolism
Hematopoietic Stem Cells/*metabolism
Valproic Acid/*pharmacology
Adult Stem Cells/cytology ; Cells, Cultured ; Hematopoietic Stem Cells/cytology ; Humans
Czasopismo naukowe
Tytuł :
Famciclovir leads to failure of hematopoiesis, but may have the benefit of relieving myeloid expansion in MDS-like zebrafish.
Autorzy :
Li J; Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China; Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou 510006, PR China.
Meng P; Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China; Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou 510006, PR China.
Zhou R; Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Zhang Y; Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China; Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou 510006, PR China. Electronic address: .
Lin Q; Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou 510006, PR China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Jan 01; Vol. 410, pp. 115334. Date of Electronic Publication: 2020 Nov 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*therapeutic use
Famciclovir/*therapeutic use
Hematopoiesis/*drug effects
Hematopoietic Stem Cells/*drug effects
Myelodysplastic Syndromes/*drug therapy
Myeloid Cells/*drug effects
Animals ; Animals, Genetically Modified ; Antiviral Agents/pharmacology ; Apoptosis/drug effects ; Apoptosis/physiology ; Famciclovir/pharmacology ; Hematopoiesis/physiology ; Hematopoietic Stem Cells/pathology ; Hematopoietic Stem Cells/physiology ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/pathology ; Myeloid Cells/pathology ; Zebrafish
Czasopismo naukowe
Tytuł :
Lentiviral Transduction for Optimal LSC/HSC Manipulation.
Autorzy :
Mostoslavsky G; Section of Gastroenterology, Department of Medicine, Center for Regenerative Medicine (CReM), Boston University School of Medicine, Boston, MA, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2185, pp. 299-306.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Vectors*
HIV-1*
Transduction, Genetic*
Hematopoietic Stem Cells/*metabolism
Cell Line ; Hematopoietic Stem Cells/cytology ; Humans
Czasopismo naukowe
Tytuł :
In Vivo Clonal Analysis of Aged Hematopoietic Stem Cells: Single-Cell Transplantation.
Autorzy :
Igarashi KJ; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Yamamoto R; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2185, pp. 181-194.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*
Hematopoietic Stem Cell Transplantation*
Single-Cell Analysis*
Hematopoietic Stem Cells/*metabolism
Allografts ; Animals ; Hematopoietic Stem Cells/cytology ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Single-cell analyses and machine learning define hematopoietic progenitor and HSC-like cells derived from human PSCs.
Autorzy :
Fidanza A; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Stumpf PS; Joint Research Center for Computational Biomedicine, Uniklinik Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany.
Ramachandran P; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
Tamagno S; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Babtie A; Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Imperial College London, London, United Kingdom; and.
Lopez-Yrigoyen M; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Taylor AH; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Easterbrook J; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Henderson BEP; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
Axton R; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Henderson NC; Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
Medvinsky A; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Ottersbach K; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Romanò N; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Forrester LM; Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
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Źródło :
Blood [Blood] 2020 Dec 17; Vol. 136 (25), pp. 2893-2904.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Differentiation*/biosynthesis
Antigens, Differentiation*/genetics
Hematopoietic Stem Cells*/cytology
Hematopoietic Stem Cells*/metabolism
Machine Learning*
Pluripotent Stem Cells*/cytology
Pluripotent Stem Cells*/metabolism
RNA-Seq*
Single-Cell Analysis*
Fetus/cytology ; Fetus/metabolism ; Gene Expression Regulation ; Humans ; Liver/cytology ; Liver/metabolism
Czasopismo naukowe
Tytuł :
Oxycodone stimulates normal and malignant hematopoietic progenitors via opioid-receptor-independent-β-catenin activation.
Autorzy :
Hu N; Department of Anesthesiology, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Yu T; Department of Anesthesiology, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Chen J; Department of Anesthesiology, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Zheng S; Department of Paediatrics, The Second Staff Hospital of Wuhan Iron and Steel Group Corporation, Wuhan, Hubei Province, China.
Yan H; Department of Anesthesiology, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Duan J; Department of Anesthesiology, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Dec 17; Vol. 533 (4), pp. 1457-1463. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cells/*drug effects
Leukemia, Myeloid, Acute/*pathology
Oxycodone/*pharmacology
Receptors, Opioid/*metabolism
beta Catenin/*metabolism
Aged ; Aged, 80 and over ; Antigens, CD34/metabolism ; Cell Self Renewal/drug effects ; Cells, Cultured ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/pathology ; Humans ; Middle Aged ; Naloxone/pharmacology ; Narcotic Antagonists/pharmacology ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe

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