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Tytuł :
High-Throughput Assessment of the Abiotic Stability of Test Chemicals in In Vitro Bioassays.
Autorzy :
Huchthausen J; Department of Cell Toxicology, Helmholtz Centre for Environmental Research─UFZ, Permoserstr. 15, DE-04318 Leipzig, Germany.
Henneberger L; Department of Cell Toxicology, Helmholtz Centre for Environmental Research─UFZ, Permoserstr. 15, DE-04318 Leipzig, Germany.
Mälzer S; Department of Cell Toxicology, Helmholtz Centre for Environmental Research─UFZ, Permoserstr. 15, DE-04318 Leipzig, Germany.
Nicol B; Safety and Environmental Assurance Centre, Unilever, Colworth House, Sharnbrook, Bedford MK44 1LQ, U.K.
Sparham C; Safety and Environmental Assurance Centre, Unilever, Colworth House, Sharnbrook, Bedford MK44 1LQ, U.K.
Escher BI; Department of Cell Toxicology, Helmholtz Centre for Environmental Research─UFZ, Permoserstr. 15, DE-04318 Leipzig, Germany.; Environmental Toxicology, Center for Applied Geoscience, Eberhard Karls University Tübingen, DE-72076 Tübingen, Germany.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2022 May 16; Vol. 35 (5), pp. 867-879. Date of Electronic Publication: 2022 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*/methods
Solid Phase Microextraction*
Hydrolysis ; Photolysis ; Serum Albumin, Bovine/chemistry ; Water/chemistry
Czasopismo naukowe
Tytuł :
Trout and Human Plasma Protein Binding of Selected Pharmaceuticals Informs the Fish Plasma Model.
Autorzy :
Henneberger L; Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Klüver N; Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Mühlenbrink M; Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Escher B; Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.; Center for Applied Geoscience, Eberhard Karls University of Tübingen, Tübingen, Germany.
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Źródło :
Environmental toxicology and chemistry [Environ Toxicol Chem] 2022 Mar; Vol. 41 (3), pp. 559-568. Date of Electronic Publication: 2020 Dec 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oncorhynchus mykiss*/metabolism
Water Pollutants, Chemical*/metabolism
Animals ; Humans ; Pharmaceutical Preparations/metabolism ; Plasma/metabolism ; Protein Binding
Czasopismo naukowe
Tytuł :
Critical Membrane Concentration and Mass-Balance Model to Identify Baseline Cytotoxicity of Hydrophobic and Ionizable Organic Chemicals in Mammalian Cell Lines.
Autorzy :
Lee J; Department of Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, DE-04318 Leipzig, Germany.
Braun G; Department of Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, DE-04318 Leipzig, Germany.
Henneberger L; Department of Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, DE-04318 Leipzig, Germany.
König M; Department of Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, DE-04318 Leipzig, Germany.
Schlichting R; Department of Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, DE-04318 Leipzig, Germany.
Scholz S; Department of Bioanalytical Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, DE-04318 Leipzig, Germany.
Escher BI; Department of Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15, DE-04318 Leipzig, Germany.; Environmental Toxicology, Center for Applied Geoscience, Eberhard Karls University Tübingen, Scharrenbergstrasse 94-96, DE-72076 Tübingen, Germany.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2021 Sep 20; Vol. 34 (9), pp. 2100-2109. Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Organic Chemicals/*toxicity
Cell Line, Tumor ; Humans ; Hydrophobic and Hydrophilic Interactions ; Models, Chemical ; Organic Chemicals/chemistry ; Quantitative Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Suspended Particulate Matter-A Source or Sink for Chemical Mixtures of Organic Micropollutants in a Small River under Baseflow Conditions?
Autorzy :
Niu L
Ahlheim J
Glaser C; Center for Applied Geoscience, Eberhard Karls University of Tübingen, Schnarrenbergstr. 94-96, 72076 Tübingen, Germany.
Gunold R
Henneberger L
König M
Krauss M
Schwientek M; Center for Applied Geoscience, Eberhard Karls University of Tübingen, Schnarrenbergstr. 94-96, 72076 Tübingen, Germany.
Zarfl C; Center for Applied Geoscience, Eberhard Karls University of Tübingen, Schnarrenbergstr. 94-96, 72076 Tübingen, Germany.
Escher BI; Center for Applied Geoscience, Eberhard Karls University of Tübingen, Schnarrenbergstr. 94-96, 72076 Tübingen, Germany.; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, 04318 Leipzig, Germany.
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Źródło :
Environmental science & technology [Environ Sci Technol] 2021 Apr 20; Vol. 55 (8), pp. 5106-5116. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Rivers*
Water Pollutants, Chemical*/analysis
China ; Environmental Monitoring ; Fresh Water ; Geologic Sediments ; Particulate Matter/analysis
Czasopismo naukowe
Tytuł :
Quantitative In Vitro -to- In Vivo Extrapolation: Nominal versus Freely Dissolved Concentration.
Autorzy :
Henneberger L; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
Huchthausen J; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
Wojtysiak N; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
Escher BI; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.; Environmental Toxicology, Center for Applied Geoscience, Eberhard Karls University Tübingen, Schnarrenbergstr. 94-96, 72076 Tübingen, Germany.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2021 Apr 19; Vol. 34 (4), pp. 1175-1182. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Assay*
Pharmaceutical Preparations/*analysis
Humans
Czasopismo naukowe
Tytuł :
Environmental Sorption Behavior of Ionic and Ionizable Organic Chemicals.
Autorzy :
Henneberger L; Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany.
Goss KU; Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany. .; Institute of Chemistry, University of Halle-Wittenberg, Halle, Germany. .
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Źródło :
Reviews of environmental contamination and toxicology [Rev Environ Contam Toxicol] 2021; Vol. 253, pp. 43-64.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adsorption*
Organic Chemicals*
Soil*
Bioaccumulation ; Cations
Czasopismo naukowe
Tytuł :
Optimization of a pre-metabolization procedure using rat liver S9 and cell-extracted S9 in the Ames fluctuation test.
Autorzy :
Shao Y; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany; Key Laboratory of the Three Gorges Reservoir Eco-environment, Ministry of Education, Chongqing University, Shazheng street 174, Shapingba, 400044 Chongqing, China. Electronic address: .
Schiwy A; Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany; EWOMIS GmbH, Schießstraße 26c, 63486 Bruchköbel, Germany; Department of Evolutionary Ecology and Ecotoxicology, Goethe University, Max-von-Laue-Str. 13, 60438 Frankfurt/Main, Germany.
Glauch L; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany.
Henneberger L; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany.
König M; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany.
Mühlenbrink M; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany.
Xiao H; Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany; EWOMIS GmbH, Schießstraße 26c, 63486 Bruchköbel, Germany.
Thalmann B; EWOMIS GmbH, Schießstraße 26c, 63486 Bruchköbel, Germany.
Schlichting R; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany.
Hollert H; Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany; EWOMIS GmbH, Schießstraße 26c, 63486 Bruchköbel, Germany; Department of Evolutionary Ecology and Ecotoxicology, Goethe University, Max-von-Laue-Str. 13, 60438 Frankfurt/Main, Germany.
Escher BI; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany; EWOMIS GmbH, Schießstraße 26c, 63486 Bruchköbel, Germany; Eberhard Karls University of Tübingen, Environmental Toxicology, Centre for Applied Geosciences, 72074 Tubingen, Germany.
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Źródło :
The Science of the total environment [Sci Total Environ] 2020 Dec 20; Vol. 749, pp. 141468. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Mutagens*
Salmonella typhimurium*/genetics
Animals ; Biotransformation ; Cell Extracts/pharmacology ; Liver ; Microsomes, Liver/metabolism ; Mutagenicity Tests ; Rats
Czasopismo naukowe
Tytuł :
Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In Vitro - In Vivo Extrapolation.
Autorzy :
Fischer FC; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Abele C; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Henneberger L; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Klüver N; Department Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
König M; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Mühlenbrink M; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Schlichting R; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Escher BI; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.; Centre for Applied Geoscience, Eberhard Karls University Tübingen, 72074 Tübingen, Germany.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2020 Jul 20; Vol. 33 (7), pp. 1770-1779. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Assay*
Models, Biological*
Benzopyrenes/*pharmacology
Cytochrome P-450 CYP1A1/*genetics
Cytochrome P-450 CYP1A1/*metabolism
Genes, Reporter ; HEK293 Cells ; Hep G2 Cells ; Humans ; MCF-7 Cells ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Experimental Exposure Assessment of Ionizable Organic Chemicals in In Vitro Cell-Based Bioassays.
Autorzy :
Huchthausen J; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
Mühlenbrink M; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
König M; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
Escher BI; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.; Environmental Toxicology, Center for Applied Geoscience, Eberhard Karls University Tübingen, 72074 Tübingen, Germany.
Henneberger L; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2020 Jul 20; Vol. 33 (7), pp. 1845-1854. Date of Electronic Publication: 2020 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Assay/*methods
Organic Chemicals/*toxicity
Humans ; Liposomes/chemistry ; MCF-7 Cells ; Oxidative Stress/drug effects ; PPAR gamma/metabolism ; Serum Albumin, Bovine/chemistry ; Solid Phase Microextraction ; Water/chemistry
Czasopismo naukowe
Tytuł :
Cytotoxicity Burst? Differentiating Specific from Nonspecific Effects in Tox21 in Vitro Reporter Gene Assays.
Autorzy :
Escher BI; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.; Environmental Toxicology, Center for Applied Geoscience, Eberhard Karls University Tübingen, Tübingen, Germany.
Henneberger L; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
König M; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
Schlichting R; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
Fischer FC; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
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Źródło :
Environmental health perspectives [Environ Health Perspect] 2020 Jul; Vol. 128 (7), pp. 77007. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Assay*
Toxicity Tests/*methods
Genes, Reporter ; Humans ; Quantitative Structure-Activity Relationship
Czasopismo naukowe

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