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Wyszukujesz frazę ""Hep G2 Cells"" wg kryterium: Temat


Tytuł:
The cytotoxic effects of prazosin, chlorpromazine, and haloperidol on hepatocellular carcinoma and immortalized non-tumor liver cells.
Autorzy:
Harris S; Department of Biology, Missouri State University, Springfield, MO, USA.
Nagarajan P; Thomas Jefferson Independent Day School, Joplin, MO, USA.
Kim K; Thomas Jefferson Independent Day School, Joplin, MO, USA. .
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Źródło:
Medical oncology (Northwood, London, England) [Med Oncol] 2024 Mar 12; Vol. 41 (4), pp. 87. Date of Electronic Publication: 2024 Mar 12.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
Antipsychotic Agents*/pharmacology
Antipsychotic Agents*/therapeutic use
Antineoplastic Agents*/therapeutic use
Humans ; Haloperidol/pharmacology ; Haloperidol/therapeutic use ; Chlorpromazine/pharmacology ; Chlorpromazine/therapeutic use ; Prazosin/pharmacology ; Prazosin/therapeutic use ; Hep G2 Cells ; Apoptosis ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
ZNF692 drives malignant development of hepatocellular carcinoma cells by promoting ALDOA-dependent glycolysis.
Autorzy:
Meng W; Department of Laboratory, Shenzhen Baoan Shiyan People's Hospital, No. 11, Jixiang Road, Shiyan Street, Baoan District, Shenzhen, Guangdong, 518108, P.R. China.
Lu X; Department of Laboratory, Shenzhen Baoan Shiyan People's Hospital, No. 11, Jixiang Road, Shiyan Street, Baoan District, Shenzhen, Guangdong, 518108, P.R. China.
Wang G; Department of Laboratory, Shenzhen Baoan Shiyan People's Hospital, No. 11, Jixiang Road, Shiyan Street, Baoan District, Shenzhen, Guangdong, 518108, P.R. China.
Xiao Q; Department of Blood Transfusion, Shenzhen Baoan Shiyan People's Hospital, Shenzhen, Guangdong, 518108, P.R. China.
Gao J; Department of Laboratory, Shenzhen Baoan Shiyan People's Hospital, No. 11, Jixiang Road, Shiyan Street, Baoan District, Shenzhen, Guangdong, 518108, P.R. China. .
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Źródło:
Functional & integrative genomics [Funct Integr Genomics] 2024 Mar 08; Vol. 24 (2), pp. 53. Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Liver Neoplasms*/pathology
Humans ; Cell Line, Tumor ; Hep G2 Cells ; Glycolysis ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Fructose-Bisphosphate Aldolase/genetics ; Fructose-Bisphosphate Aldolase/metabolism
Czasopismo naukowe
Tytuł:
Carrier-free self-assembled nanomedicine based on celastrol and galactose for targeting therapy of hepatocellular carcinoma via inducing ferroptosis.
Autorzy:
Zhang X; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Chen Y; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Li X; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Xu H; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Yang J; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Wang C; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Zhang C; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Deng Y; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Lu A; Institute for Advancing Translational Medicine in Bone&Joint-Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 999077, China. Electronic address: .
Zheng C; Sichuan Key Laboratory of TCM Regulating Metabolic Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China. Electronic address: .
Lu J; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Institute for Advancing Translational Medicine in Bone&Joint-Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 999077, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2024 Mar 05; Vol. 267, pp. 116183. Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
Ferroptosis*
Pentacyclic Triterpenes*
Humans ; Mice ; Animals ; Galactose ; Nanomedicine ; Ligands ; Hep G2 Cells
Czasopismo naukowe
Tytuł:
Evaluation of the cytotoxic activity of sorafenib-loaded camel milk casein nanoparticles against hepatocarcinoma cells.
Autorzy:
Mittal A; Department of Biological Sciences, Birla Institute of Technology of Science (BITS), Pilani Campus, Pilani, Rajasthan, India.
Mahala N; Department of Biological Sciences, Birla Institute of Technology of Science (BITS), Pilani Campus, Pilani, Rajasthan, India.; Department of Biotechnology, Parul Institute of Technology, Parul University, Vadodara, Gujarat, India.
Dhanawade NH; Department of Biological Sciences, Birla Institute of Technology of Science (BITS), Pilani Campus, Pilani, Rajasthan, India.
Dubey SK; R & D Healthcare Division Emami Ltd, Kolkata, India.
Dubey US; Department of Biological Sciences, Birla Institute of Technology of Science (BITS), Pilani Campus, Pilani, Rajasthan, India.
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Źródło:
Biotechnology journal [Biotechnol J] 2024 Mar; Vol. 19 (3), pp. e2300449.
Typ publikacji:
Journal Article
MeSH Terms:
Liver Neoplasms*/metabolism
Antineoplastic Agents*/pharmacology
Carcinoma, Hepatocellular*/drug therapy
Nanoparticles*
Animals ; Humans ; Sorafenib/pharmacology ; Sorafenib/therapeutic use ; Camelus ; Caseins/pharmacology ; Caseins/therapeutic use ; Milk ; Hep G2 Cells ; Cell Line, Tumor ; Apoptosis
Czasopismo naukowe
Tytuł:
Biopesticide Turex®'s cytotoxicity, genotoxicity and cell cycle arrest on HepG2 cell line.
Autorzy:
Oskoei P; Department of Biology & CESAM, University of Aveiro, Aveiro, Portugal. Electronic address: .
Guilherme S; Department of Biology & CESAM, University of Aveiro, Aveiro, Portugal.
Oliveira H; Department of Biology & CESAM, University of Aveiro, Aveiro, Portugal.
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Źródło:
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Mar; Vol. 240, pp. 107653. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Biological Control Agents*/pharmacology
Pesticides*/toxicity
Humans ; Hep G2 Cells ; Ecosystem ; DNA Damage ; Cell Cycle Checkpoints ; Cell Cycle ; Cell Survival
Czasopismo naukowe
Tytuł:
Activation of AMPK pathway by low‑dose donafenib and atorvastatin combination improves high‑fat diet‑induced metabolic dysfunction‑associated steatotic liver disease.
Autorzy:
Bai Y; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Chen K; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Liu J; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Wang Y; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Wang C; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Ju S; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Zhou C; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Yao W; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Xiong B; Department of Interventional Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Zheng C; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2024 Mar; Vol. 29 (3). Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/etiology
Non-alcoholic Fatty Liver Disease*/complications
Metabolic Diseases*/complications
Pyridines*
Rats ; Animals ; Humans ; AMP-Activated Protein Kinases/metabolism ; Atorvastatin/pharmacology ; Atorvastatin/therapeutic use ; Reactive Oxygen Species/metabolism ; Diet, High-Fat/adverse effects ; Liver/metabolism ; Lipid Metabolism ; Hep G2 Cells
Czasopismo naukowe
Tytuł:
Genome-wide loss-of-function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus-integrated hepatoma cells.
Autorzy:
Fukuoka M; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Kodama T; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Murai K; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Hikita H; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Sometani E; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Sung J; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Shimoda A; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Shigeno S; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Motooka D; Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Nishio A; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Furuta K; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Tatsumi T; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Yusa K; Stem Cell Genetics, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Takehara T; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
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Źródło:
Cancer science [Cancer Sci] 2024 Mar; Vol. 115 (3), pp. 859-870. Date of Electronic Publication: 2024 Jan 29.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/genetics
Hepatitis B*/genetics
Humans ; Hepatitis B virus/genetics ; Hepatitis B virus/metabolism ; RNA, Guide, CRISPR-Cas Systems ; Cell Line ; Hep G2 Cells ; RNA, Small Interfering/metabolism ; Virus Replication/genetics ; DNA, Viral/genetics ; Membrane Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism
Czasopismo naukowe
Tytuł:
Untargeted metabolomics reveals the regulatory effect of geniposidic acid on lipid accumulation in HepG2 cells and Caenorhabditis elegans and validation in hyperlipidemic hamsters.
Autorzy:
Huang H; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, PR China.
Gu Q; The College of Forestry, Beijing Forestry University, Beijing 100083, PR China.
Nie SM; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, PR China.
Wang JD; The College of Forestry, Beijing Forestry University, Beijing 100083, PR China.
Zhao H; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, PR China.
Zhai BW; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, PR China.
Zhang MY; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, PR China.
Fu YJ; The College of Forestry, Beijing Forestry University, Beijing 100083, PR China. Electronic address: yujie_.
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Źródło:
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2024 Mar; Vol. 125, pp. 155295. Date of Electronic Publication: 2023 Dec 17.
Typ publikacji:
Journal Article
MeSH Terms:
Caenorhabditis elegans*/metabolism
Hyperlipidemias*/drug therapy
Iridoid Glucosides*
Cricetinae ; Animals ; Mice ; Humans ; Hep G2 Cells ; Reactive Oxygen Species/metabolism ; Mesocricetus ; Metabolomics ; Lipids ; Lipid Metabolism
Czasopismo naukowe
Tytuł:
PreS1BP mediates inhibition of Hepatitis B virus replication by promoting HBx protein degradation.
Autorzy:
Wang J; Peking University Ditan Teaching Hospital, Beijing 100015, China; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Yuan X; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; The Division of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Wang Y; The Division of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Zhang Y; The Division of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Han M; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; The Division of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Lu H; Hebei Utu Pharmaceutical Company Ltd, Shijiazhuang, Hebei Province 052165, China.
Liu S; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; The Division of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Zhang Y; Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Ge F; Department of Chinese Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Liu Y; Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China. Electronic address: .
Cheng J; Peking University Ditan Teaching Hospital, Beijing 100015, China; Hebei Utu Pharmaceutical Company Ltd, Shijiazhuang, Hebei Province 052165, China. Electronic address: .
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Źródło:
Virus research [Virus Res] 2024 Mar; Vol. 341, pp. 199326. Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatitis B virus*/genetics
Hepatitis B*
Animals ; Humans ; Hepatitis B Surface Antigens/genetics ; Hepatitis B Surface Antigens/metabolism ; Proteolysis ; Hepatitis B Core Antigens/metabolism ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Hep G2 Cells ; Viral Regulatory and Accessory Proteins/genetics ; DNA, Circular/metabolism ; Virus Replication/genetics ; RNA/metabolism ; Ubiquitins/genetics
Czasopismo naukowe
Tytuł:
Quantitative determination of the intracellular uptake of silica nanoparticles using asymmetric flow field flow fractionation coupled with ICP mass spectrometry and their cytotoxicity in HepG2 cells.
Autorzy:
Tanaka YK; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 260-8675, Japan. .
Ogra Y; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba, 260-8675, Japan.
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Źródło:
Archives of toxicology [Arch Toxicol] 2024 Mar; Vol. 98 (3), pp. 769-777. Date of Electronic Publication: 2024 Jan 14.
Typ publikacji:
Journal Article
MeSH Terms:
Fractionation, Field Flow*/methods
Nanoparticles*/toxicity
Nanoparticles*/chemistry
Humans ; Silicon Dioxide/toxicity ; Silicon Dioxide/chemistry ; Hep G2 Cells ; Mass Spectrometry/methods ; Particle Size
Czasopismo naukowe
Tytuł:
The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability.
Autorzy:
Vlasveld M; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Callegaro G; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Fisher C; Certara UK Limited (Simcyp Division), Sheffield, UK.
Eakins J; Cyprotex Discovery Ltd., Macclesfield, UK.
Walker P; Cyprotex Discovery Ltd., Macclesfield, UK.
Lok S; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
van Oost S; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
de Jong B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Pellegrino-Coppola D; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Burger G; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Wink S; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2024 Mar; Vol. 44 (3), pp. 760-775. Date of Electronic Publication: 2024 Jan 13.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*/metabolism
Chemical and Drug Induced Liver Injury*/genetics
Chemical and Drug Induced Liver Injury*/metabolism
Humans ; Hep G2 Cells ; Oxidative Stress ; Gene Expression Profiling
Czasopismo naukowe
Tytuł:
Chiral separation and bioactivities of six pairs of enantiomeric dilignans from Magnolia officinalis var. biloba.
Autorzy:
Zang YD; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Zang CX; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Tian JY; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Xu KL; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Li C; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Li CJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Yang Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Ye F; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Zhang D; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Zhang DM; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China. Electronic address: .
Ma J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China. Electronic address: .
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Źródło:
Phytochemistry [Phytochemistry] 2024 Mar; Vol. 219, pp. 113964. Date of Electronic Publication: 2024 Jan 04.
Typ publikacji:
Journal Article
MeSH Terms:
Magnolia*/chemistry
Humans ; Magnetic Resonance Spectroscopy ; Hep G2 Cells ; Molecular Structure
Czasopismo naukowe
Tytuł:
Proprotein convertase subtilisin/kexin 9 inhibitor downregulates microRNA-130a-3p expression in hepatocytes to alleviates atherosclerosis progression.
Autorzy:
Xu J; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China.; TianJin Institute of Cardiovascular Diseases, Tianjin, China.
Zuo J; Internal Medicine, Tianjin Jinnan Hospital, Tianjin, China.
Han C; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China.; TianJin Institute of Cardiovascular Diseases, Tianjin, China.
Li T; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China.; TianJin Institute of Cardiovascular Diseases, Tianjin, China.
Jin D; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China.; TianJin Institute of Cardiovascular Diseases, Tianjin, China.
Zhao F; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China.; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China.; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China.; TianJin Institute of Cardiovascular Diseases, Tianjin, China.
Cong H; The Department of Cardiology, Tianjin Chest Hospital, No. 261, Taierzhuang South Road, Jinnan District, Tianjin, 300222, China. .; The Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, China. .; Tianjin Key Laboratory of Cardiovascular Emergency and Critical Care, Tianjin Municipal Science and Technology Bureau, Tianjin, China. .; TianJin Institute of Cardiovascular Diseases, Tianjin, China. .
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Źródło:
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Mar; Vol. 397 (3), pp. 1727-1736. Date of Electronic Publication: 2023 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Coronary Artery Disease*
Atherosclerosis*/drug therapy
Atherosclerosis*/genetics
Atherosclerosis*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Mice ; Animals ; Humans ; Proprotein Convertase 9/genetics ; Proprotein Convertase 9/metabolism ; Proprotein Convertase 9/pharmacology ; Subtilisin/metabolism ; Subtilisin/pharmacology ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Mice, Knockout, ApoE ; Proprotein Convertases/genetics ; Proprotein Convertases/metabolism ; Proprotein Convertases/pharmacology ; Hepatocytes ; Hep G2 Cells
Czasopismo naukowe
Tytuł:
Comprehensive Transcriptome Profiling of Antioxidant Activities by Glutathione in Human HepG2 Cells.
Autorzy:
Uchida Y; Research and Development Division, Mitsubishi Corporation Life Sciences Ltd., 1-1-3 Yurakucho, Tokyo 100-0006, Japan.
Ferdousi F; Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.; Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba 305-8572, Japan.; Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMed-OIL), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8577, Japan.
Takahashi S; Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.; Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba 305-8572, Japan.
Isoda H; Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.; Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba 305-8572, Japan.; Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMed-OIL), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8577, Japan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 29; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Antioxidants*/pharmacology
Phosphatidylinositol 3-Kinases*/metabolism
Humans ; Hep G2 Cells ; Glutathione/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Gene Expression Profiling ; Hydrogen Peroxide/pharmacology ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Tytuł:
Purification and Identification of Peptides from Hydrilla verticillata (Linn. f.) Royle with Cytoprotective and Antioxidative Effect against H 2 O 2 -Treated HepG2 Cells.
Autorzy:
Tang Y; College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
Liang F; College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
Yan Y; College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
Zeng Y; College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
Li Y; College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
Zhou R; College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
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Źródło:
Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Feb 28; Vol. 72 (8), pp. 4170-4183. Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Antioxidants*/chemistry
Hydrocharitaceae*/metabolism
Humans ; Hydrogen Peroxide/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; Hep G2 Cells ; Tandem Mass Spectrometry ; Molecular Docking Simulation ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Peptides/chemistry ; Oxidative Stress
Czasopismo naukowe
Tytuł:
Clemastine/tamoxifen hybrids as easily accessible antileishmanial drug leads.
Autorzy:
Agostino VS; Department of Chemistry, Durham University, UK. .; Department of Animal Biology, Institute of Biology, University of Campinas, Brazil.
Buerdsell ML; Department of Chemistry, Durham University, UK. .
Uliana SRB; Department of Parasitology, Biomedical Sciences Institute, University of Sao Paulo, Brazil.
Denny PW; Department of Biosciences, Durham University, UK.
Coelho AC; Department of Animal Biology, Institute of Biology, University of Campinas, Brazil.
Steel PG; Department of Chemistry, Durham University, UK. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2024 Feb 28; Vol. 22 (9), pp. 1812-1820. Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Leishmaniasis, Cutaneous*/drug therapy
Leishmaniasis, Cutaneous*/parasitology
Antiprotozoal Agents*/pharmacology
Humans ; Animals ; Mice ; Clemastine/therapeutic use ; Macrophages ; Hep G2 Cells ; Mice, Inbred BALB C
Czasopismo naukowe
Tytuł:
Hepa-ToxMOA: a pathway-screening method for evaluating cellular stress and hepatic metabolic-dependent toxicity of natural products.
Autorzy:
Park SM; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea.; College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 34131, Daejeon, Republic of Korea.
Choi MS; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea.; College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 34131, Daejeon, Republic of Korea.
Kim S; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea.
Jegal H; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea.; Department of Human and Environmental Toxicology, University of Science & Technology, 34113, Daejeon, Republic of Korea.
Han HY; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea.; Department of Human and Environmental Toxicology, University of Science & Technology, 34113, Daejeon, Republic of Korea.
Chun HS; Food Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, 17546, Anseong, South Korea.
Kim SK; College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 34131, Daejeon, Republic of Korea. .
Oh JH; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea. .; Department of Human and Environmental Toxicology, University of Science & Technology, 34113, Daejeon, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 21; Vol. 14 (1), pp. 4319. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
NF-kappa B*/metabolism
Gene Expression Regulation*
Humans ; Hep G2 Cells ; Green Fluorescent Proteins/metabolism ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Tytuł:
Enhanced Efficiency of Pd(0)-Based Single Chain Polymeric Nanoparticles for in Vitro Prodrug Activation by Modulating the Polymer's Microstructure.
Autorzy:
Deng L; Laboratory for Macromolecular and Organic Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.; Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Sathyan A; Laboratory for Macromolecular and Organic Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.; Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Adam C; Edinburgh Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, United Kingdom.
Unciti-Broceta A; Edinburgh Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, United Kingdom.
Sebastian V; Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, Zaragoza 50009, Spain.; Department of Chemical and Environmental Engineering, Universidad de Zaragoza, Campus Rio Ebro, 50018 Zaragoza, Spain.; Laboratorio de Microscopías Avanzadas, Universidad de Zaragoza, 50018 Zaragoza, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain.
Palmans ARA; Laboratory for Macromolecular and Organic Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.; Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
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Źródło:
Nano letters [Nano Lett] 2024 Feb 21; Vol. 24 (7), pp. 2242-2249. Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
Prodrugs*/chemistry
Antineoplastic Agents*/chemistry
Nanoparticles*/chemistry
Humans ; Polymers/chemistry ; Hep G2 Cells ; Catalysis
Czasopismo naukowe
Tytuł:
Bulbils of Aerial Yam Attenuate Ethanol-Induced Hepatotoxicity in HepG2 Cells through Inhibition of Oxidative Stress by Activation of the Nuclear Factor Erythroid-2-Related Factor 2 Signaling Pathway.
Autorzy:
Yang DK; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Jeollabuk-do, Republic of Korea.
Tungalag T; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Jeollabuk-do, Republic of Korea.; Biosafety Research Institute and Laboratory of Pathology, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Jeollabuk-do, Republic of Korea.
Kang HS; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Jeollabuk-do, Republic of Korea.
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Źródło:
Nutrients [Nutrients] 2024 Feb 16; Vol. 16 (4). Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Dioscorea*
Chemical and Drug Induced Liver Injury*/drug therapy
Chemical and Drug Induced Liver Injury*/prevention & control
Humans ; Ethanol/toxicity ; Hep G2 Cells ; Reactive Oxygen Species/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells.
Autorzy:
Castillejo-López C; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 08 , Uppsala, Sweden, Box 815, Husargatan 3, BMC.
Bárcenas-Walls JR; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 08 , Uppsala, Sweden, Box 815, Husargatan 3, BMC.
Cavalli M; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 08 , Uppsala, Sweden, Box 815, Husargatan 3, BMC.
Larsson A; Department of Medical Sciences, Clinical Chemistry, Uppsala University Hospital, 751 85, Uppsala, Sweden.
Wadelius C; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 08 , Uppsala, Sweden, Box 815, Husargatan 3, BMC. .
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2024 Feb 16; Vol. 23 (1), pp. 48. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/genetics
Non-alcoholic Fatty Liver Disease*/metabolism
Humans ; Cholesterol, LDL/genetics ; Genome-Wide Association Study ; Hep G2 Cells ; Promoter Regions, Genetic/genetics ; Transcription Factors/genetics ; Triglycerides/metabolism ; Iodide Peroxidase/genetics ; Cholesterol, HDL/genetics ; Cholesterol, HDL/metabolism
Czasopismo naukowe

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