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Tytuł :
DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1α signaling pathways in HepG2 cells.
Autorzy :
Liu H; College of Food Science, South China Agricultural University, Guangzhou 510642, China; Guangdong Provincial Key Laboratory of Food Quality and Safety, Guangzhou 510642, China. Electronic address: .
Zhu S; College of Food Science, South China Agricultural University, Guangzhou 510642, China; Guangdong Provincial Key Laboratory of Food Quality and Safety, Guangzhou 510642, China. Electronic address: .
Han W; College of Food Science, South China Agricultural University, Guangzhou 510642, China; Guangdong Provincial Key Laboratory of Food Quality and Safety, Guangzhou 510642, China. Electronic address: .
Cai Y; College of Food Science, South China Agricultural University, Guangzhou 510642, China. Electronic address: .
Liu C; College of Food Science, South China Agricultural University, Guangzhou 510642, China; Guangdong Provincial Key Laboratory of Food Quality and Safety, Guangzhou 510642, China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Sep 15; Vol. 221, pp. 112449. Date of Electronic Publication: 2021 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Endocrine Disruptors/*toxicity
Mitochondria/*drug effects
NF-E2-Related Factor 2/*metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*metabolism
Phthalic Acids/*toxicity
Sirtuin 1/*metabolism
Hep G2 Cells ; Humans ; Mitochondria/physiology ; Oxidative Stress/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Effect of trivalent chromium on erythropoietin production and the prevention of insulin resistance in HepG2 cells.
Autorzy :
Nishimura K; Laboratory of Bioenvironmental Sciences, Course of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku Ohrai-Kita, Izumisano, Osaka, 598-8531, Japan. Electronic address: .
Iitaka S; Laboratory of Bioenvironmental Sciences, Course of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku Ohrai-Kita, Izumisano, Osaka, 598-8531, Japan.
Nakagawa H; Laboratory of Bioenvironmental Sciences, Course of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku Ohrai-Kita, Izumisano, Osaka, 598-8531, Japan.
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Sep 15; Vol. 708, pp. 108960. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Resistance*
Chromium/*chemistry
Chromium/*pharmacology
Erythropoietin/*biosynthesis
Hep G2 Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Phosphorylation/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Combined effects of different sizes of ZnO and ZIF-8 nanoparticles co-exposure with Cd on HepG2 cells.
Autorzy :
Chen P; Department of Chemistry, Wuhan University, Wuhan 430072, China.
Chen B; Department of Chemistry, Wuhan University, Wuhan 430072, China.
He M; Department of Chemistry, Wuhan University, Wuhan 430072, China.
Hu B; Department of Chemistry, Wuhan University, Wuhan 430072, China. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 Sep 10; Vol. 786, pp. 147402. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article
MeSH Terms :
Metal Nanoparticles*/toxicity
Nanoparticles*/toxicity
Zinc Oxide*/toxicity
Cadmium/toxicity ; Hep G2 Cells ; Zinc
Czasopismo naukowe
Tytuł :
Mechanisms linking hypoxia to phosphorylation of insulin-like growth factor binding protein-1 in baboon fetuses with intrauterine growth restriction and in cell culture.
Autorzy :
Kakadia J; Department of Biochemistry, University of Western Ontario, London, ON, Canada.
Biggar K; Institute of Biochemistry, Carleton University, Ottawa, ON, Canada.
Jain B; Department of Biochemistry, University of Western Ontario, London, ON, Canada.
Chen AW; Department of Biochemistry, University of Western Ontario, London, ON, Canada.
Nygard K; Biotron Integrated Microscopy Facility, University of Western Ontario, London, ON, Canada.
Li C; Department of Animal Science, University of Wyoming, Laramie, WY, USA.; Southwest National Primate Research Center, San Antonio, TX, USA.
Nathanielsz PW; Department of Animal Science, University of Wyoming, Laramie, WY, USA.; Southwest National Primate Research Center, San Antonio, TX, USA.
Jansson T; Department of Obstetrics and Gynecology, Division of Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Gupta MB; Department of Biochemistry, University of Western Ontario, London, ON, Canada.; Children's Health Research Institute, London, ON, Canada.; Department of Pediatrics, University of Western Ontario, London, ON, Canada.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Sep; Vol. 35 (9), pp. e21788.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Culture Techniques*
Disease Models, Animal*
Fetal Growth Retardation/*metabolism
Fetus/*metabolism
Hypoxia/*metabolism
Insulin-Like Growth Factor Binding Protein 1/*metabolism
Animals ; Erythropoietin/metabolism ; Fetal Weight ; Fetus/chemistry ; Hep G2 Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; In Vitro Techniques ; Insulin-Like Growth Factor Binding Protein 1/chemistry ; Mechanistic Target of Rapamycin Complex 1/antagonists & inhibitors ; Microscopy, Fluorescence ; Organ Size ; Papio ; Phosphorylation ; Protein Kinase C-alpha/metabolism ; Receptors, Erythropoietin/metabolism ; Transcription Factors/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Bifunctional small molecules that mediate the degradation of extracellular proteins.
Autorzy :
Caianiello DF; Department of Chemistry, Yale University, New Haven, CT, USA.
Zhang M; Department of Chemistry, Yale University, New Haven, CT, USA.; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Ray JD; Department of Chemistry, Yale University, New Haven, CT, USA.
Howell RA; Department of Chemistry, Yale University, New Haven, CT, USA.
Swartzel JC; Department of Chemistry, Yale University, New Haven, CT, USA.; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.
Branham EMJ; Department of Chemistry, Yale University, New Haven, CT, USA.
Chirkin E; Department of Chemistry, Yale University, New Haven, CT, USA.
Sabbasani VR; Department of Chemistry, Yale University, New Haven, CT, USA.
Gong AZ; Department of Chemistry, Yale University, New Haven, CT, USA.
McDonald DM; Department of Chemistry, Yale University, New Haven, CT, USA.
Muthusamy V; Yale Center for Precision Cancer Modeling, Yale University School of Medicine, New Haven, CT, USA.
Spiegel DA; Department of Chemistry, Yale University, New Haven, CT, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Sep; Vol. 17 (9), pp. 947-953. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Asialoglycoprotein Receptor/*metabolism
Small Molecule Libraries/*pharmacology
Animals ; Dinitrophenols/chemistry ; Dinitrophenols/metabolism ; Hep G2 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Small Molecule Libraries/chemistry
Czasopismo naukowe
Tytuł :
Higher oral efficacy of ravuconazole in self-nanoemulsifying systems in shorter treatment in experimental chagas disease.
Autorzy :
Spósito PÁ; Laboratory of Pharmaceutics and Nanotechnology (LDGNano), Pharmacy School, Federal University of Ouro Preto, Minas Gerais, 35400-000, Brazil.
Mazzeti AL; Laboratory of Pharmaceutics and Nanotechnology (LDGNano), Pharmacy School, Federal University of Ouro Preto, Minas Gerais, 35400-000, Brazil; Laboratory of Cellular Biology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil.
de Castro KCMP; Laboratory of Pharmaceutics and Nanotechnology (LDGNano), Pharmacy School, Federal University of Ouro Preto, Minas Gerais, 35400-000, Brazil; Laboratory of Parasitic Diseases, School of Medicine, Federal University of Ouro Preto, Minas Gerais, Brazil.
Mendes PF; Laboratory of Pharmaceutics and Nanotechnology (LDGNano), Pharmacy School, Federal University of Ouro Preto, Minas Gerais, 35400-000, Brazil.
Urbina JA; Venezuelan Institute for Scientific Research, Caracas, 1020A, Venezuela.
Bahia MT; Laboratory of Parasitic Diseases, School of Medicine, Federal University of Ouro Preto, Minas Gerais, Brazil.
Mosqueira VCF; Laboratory of Pharmaceutics and Nanotechnology (LDGNano), Pharmacy School, Federal University of Ouro Preto, Minas Gerais, 35400-000, Brazil. Electronic address: .
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Źródło :
Experimental parasitology [Exp Parasitol] 2021 Sep; Vol. 228, pp. 108142. Date of Electronic Publication: 2021 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Chagas Disease/*drug therapy
Thiazoles/*administration & dosage
Triazoles/*administration & dosage
Trypanosoma cruzi/*drug effects
Animals ; Chagas Disease/parasitology ; Emulsions ; Female ; Hep G2 Cells ; Humans ; Inhibitory Concentration 50 ; Mice ; Myocytes, Cardiac ; Nanostructures ; Rats ; Thiazoles/pharmacology ; Thiazoles/therapeutic use ; Thiazoles/toxicity ; Triazoles/pharmacology ; Triazoles/therapeutic use ; Triazoles/toxicity
Czasopismo naukowe
Tytuł :
Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease.
Autorzy :
Joshi A; Division of Chronobiology and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, India.
Upadhyay KK; Department of Internal medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Vohra A; Division of Chronobiology and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, India.
Shirsath K; Division of Chronobiology and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, India.
Devkar R; Division of Chronobiology and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara, India.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Sep; Vol. 35 (9), pp. e21803.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Circadian Rhythm/*drug effects
Heme Oxygenase-1/*metabolism
Liver/*drug effects
Liver/*metabolism
Melatonin/*pharmacology
NF-E2-Related Factor 2/*metabolism
Non-alcoholic Fatty Liver Disease/*metabolism
Animals ; Circadian Clocks/drug effects ; Hep G2 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Period Circadian Proteins/metabolism ; Sterol Regulatory Element Binding Protein 1/metabolism
Czasopismo naukowe
Tytuł :
TCF19 and p53 regulate transcription of TIGAR and SCO2 in HCC for mitochondrial energy metabolism and stress adaptation.
Autorzy :
Mondal P; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India.; Department of Life Sciences, Homi Bhaba National Institute, Mumbai, India.
Gadad SS; Department of Molecular and Translational Medicine, Center of Emphasis in Cancer, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.
Adhikari S; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India.; Department of Life Sciences, Homi Bhaba National Institute, Mumbai, India.
Ramos EI; Department of Molecular and Translational Medicine, Center of Emphasis in Cancer, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.
Sen S; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India.
Prasad P; Cell Biology and Physiology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Das C; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India.; Department of Life Sciences, Homi Bhaba National Institute, Mumbai, India.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Sep; Vol. 35 (9), pp. e21814.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis Regulatory Proteins/*genetics
Carcinoma, Hepatocellular/*genetics
Liver Neoplasms/*genetics
Mitochondria/*genetics
Molecular Chaperones/*genetics
Phosphoric Monoester Hydrolases/*genetics
Transcription Factors/*genetics
Transcription, Genetic/*genetics
Tumor Suppressor Protein p53/*genetics
Adaptation, Biological/genetics ; Apoptosis/genetics ; Cell Line, Tumor ; Energy Metabolism/genetics ; Glucose/genetics ; Hep G2 Cells ; Homeostasis/genetics ; Humans ; Membrane Potential, Mitochondrial/genetics ; Stress, Physiological/genetics ; Transcriptional Activation/genetics
Czasopismo naukowe
Tytuł :
Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR.
Autorzy :
Helmy MA; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abdalla HA; Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Mansoura, Egypt.; Department of Clinical Biochemistry and Molecular Medicine, Faculty of Medicine, Taibah University, Medina, Saudi Arabia.
Abd El Rahman HA; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Ahmed DAM; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Sep; Vol. 51 (9), pp. 1029-1037. Date of Electronic Publication: 2021 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Proto-Oncogene Proteins c-akt*
Tramadol*/analogs & derivatives
Tramadol*/toxicity
Hep G2 Cells ; Humans ; Phosphatidylinositol 3-Kinases ; TOR Serine-Threonine Kinases
Czasopismo naukowe
Tytuł :
Anti-inflammatory norclerodane diterpenoids and tetrahydrophenanthrene from the leaves and stems of Dioscorea bulbifera.
Autorzy :
Ngan NTT; Institute of Genome Research, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Viet Nam. Electronic address: .
Hoang NH; Institute of Genome Research, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Viet Nam.
Truong VV; Institute of Genome Research, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Viet Nam.
Hien NT; Institute of Genome Research, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Viet Nam.
Lan NN; Institute of Genome Research, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Viet Nam.
Tung NV; Institute of Genome Research, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Viet Nam.
Huong PTM; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Viet Nam.
Oh H; College of Pharmacy, Wonkwang University, Iksan 570-749, Republic of Korea.
Quang TH; Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi 10072, Viet Nam. Electronic address: .
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Źródło :
Fitoterapia [Fitoterapia] 2021 Sep; Vol. 153, pp. 104965. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Dioscorea/*chemistry
Diterpenes/*pharmacology
Animals ; Anti-Inflammatory Agents/isolation & purification ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Diterpenes/isolation & purification ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Mice ; Microglia/drug effects ; Molecular Structure ; Nitric Oxide ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Leaves/chemistry ; Plant Stems/chemistry ; Vietnam
Czasopismo naukowe
Tytuł :
Lily bulbs' polyphenols extract ameliorates oxidative stress and lipid accumulation in vitro and in vivo.
Autorzy :
Kan J; College of Food Science and Engineering, Yangzhou University, Yangzhou, China.
Hui Y; College of Food Science and Engineering, Yangzhou University, Yangzhou, China.
Xie W; College of Food Science and Engineering, Yangzhou University, Yangzhou, China.
Chen C; College of Food Science and Engineering, Yangzhou University, Yangzhou, China.
Liu Y; College of Food Science and Engineering, Yangzhou University, Yangzhou, China.
Jin C; College of Food Science and Engineering, Yangzhou University, Yangzhou, China.
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Źródło :
Journal of the science of food and agriculture [J Sci Food Agric] 2021 Sep; Vol. 101 (12), pp. 5038-5048. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Fatty Liver/*drug therapy
Lilium/*chemistry
Oxidative Stress/*drug effects
Plant Extracts/*administration & dosage
Plant Roots/*chemistry
Polyphenols/*administration & dosage
Animals ; Diet, High-Fat ; Fatty Liver/genetics ; Fatty Liver/metabolism ; Hep G2 Cells ; Humans ; Lipid Metabolism/drug effects ; Male ; Mice ; Mice, Inbred ICR ; Mitochondria/drug effects ; Mitochondria/genetics ; Mitochondria/metabolism ; PPAR alpha/genetics ; PPAR alpha/metabolism ; Reactive Oxygen Species/metabolism ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism
Czasopismo naukowe
Tytuł :
Pharmacological inhibition of HDAC1/3-interacting proteins induced morphological changes, and hindered the cell proliferation and migration of hepatocellular carcinoma cells.
Autorzy :
Al-Yhya N; Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Khan MF; Bio-products Research Chair, Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia. .
Almeer RS; Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Alshehri MM; King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Aldughaim MS; Research Center, King Fahad Medical City, P.O.BOX:59046, Riyadh, 1152, Saudi Arabia.
Wadaan MA; Bio-products Research Chair, Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Sep; Vol. 28 (35), pp. 49000-49013. Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/genetics
Cell Line ; Cell Line, Tumor ; Cell Proliferation ; Hep G2 Cells ; High Mobility Group Proteins ; Histone Deacetylase 1 ; Histone Deacetylases ; Humans ; Molecular Chaperones ; Proteomics ; Transcription Factors
Czasopismo naukowe
Tytuł :
Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-κB-mediated signaling pathway in vitro and in vivo.
Autorzy :
Xun T; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Lin Z; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Wang X; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Zhan X; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Feng H; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Gan D; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Yang X; Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, China. .; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, China. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2021 Sep; Vol. 101 (9), pp. 1197-1209. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Advanced Oxidation Protein Products/*pharmacology
Cytochrome P-450 CYP1A2/*metabolism
Cytochrome P-450 CYP3A/*metabolism
Down-Regulation/*drug effects
NF-kappa B/*metabolism
Animals ; Cell Line ; Disease Models, Animal ; Hep G2 Cells ; Humans ; Male ; Microsomes, Liver/metabolism ; Rats ; Rats, Sprague-Dawley ; Renal Insufficiency, Chronic/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Combination of rehydrated whey protein isolate aqueous solution with blackcurrant concentrate and the formation of encapsulates via spray-drying and freeze-drying: Alterations to the functional properties of protein and their anticancer properties.
Autorzy :
Wu G; Department of Wine, Food and Molecular Biosciences, Faculty of Agriculture & Life Sciences, Lincoln University, Christchurch, New Zealand; Riddet Institute, Palmerston North, New Zealand. Electronic address: .
Hui X; Department of Wine, Food and Molecular Biosciences, Faculty of Agriculture & Life Sciences, Lincoln University, Christchurch, New Zealand; Riddet Institute, Palmerston North, New Zealand.
Liang J; College of Light Industry and Food, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong 510225, China.
Liu H; College of Light Industry and Food, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong 510225, China.
Chen H; Department of Wine, Food and Molecular Biosciences, Faculty of Agriculture & Life Sciences, Lincoln University, Christchurch, New Zealand; Riddet Institute, Palmerston North, New Zealand.
Gong X; Department of Wine, Food and Molecular Biosciences, Faculty of Agriculture & Life Sciences, Lincoln University, Christchurch, New Zealand.
Brennan MA; Department of Wine, Food and Molecular Biosciences, Faculty of Agriculture & Life Sciences, Lincoln University, Christchurch, New Zealand.
Zeng XA; School of Food Science of Engineering, South China University of Technology, Guangzhou 510641, China.
Guo X; School of Food Science of Engineering, South China University of Technology, Guangzhou 510641, China.
Brennan CS; Department of Wine, Food and Molecular Biosciences, Faculty of Agriculture & Life Sciences, Lincoln University, Christchurch, New Zealand; Riddet Institute, Palmerston North, New Zealand; School of Food Science of Engineering, South China University of Technology, Guangzhou 510641, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Sep 01; Vol. 355, pp. 129620. Date of Electronic Publication: 2021 Mar 20.
Typ publikacji :
Journal Article
MeSH Terms :
Plant Extracts/*pharmacology
Ribes/*chemistry
Whey Proteins/*pharmacology
Anthocyanins/chemistry ; Capsules/chemistry ; Cell Survival/drug effects ; Desiccation ; Freeze Drying ; Fruit and Vegetable Juices ; Hep G2 Cells ; Humans ; Molecular Docking Simulation ; Plant Extracts/chemistry ; Whey Proteins/isolation & purification
Czasopismo naukowe
Tytuł :
A novel platform for drug testing: Biomimetic three-dimensional hyaluronic acid-based scaffold seeded with human hepatocarcinoma cells.
Autorzy :
Turtoi M; 'Medical and Pharmaceutical Bionanotechnologies' Laboratory, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 050568 Bucharest, Romania.
Anghelache M; 'Medical and Pharmaceutical Bionanotechnologies' Laboratory, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 050568 Bucharest, Romania.
Bucatariu SM; Department of Natural Polymers, Bioactive and Biocompatible Materials, 'Petru Poni' Institute of Macromolecular Chemistry, 700487 Iassy, Romania.
Deleanu M; 'Liquid and Gas Chromatography' Laboratory, Department of Lipidomics, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 050568 Bucharest, Romania; Faculty of Biotechnologies, University of Agronomic Sciences and Veterinary Medicine of Bucharest (UASVM), 050568 Bucharest, Romania.
Voicu G; 'Medical and Pharmaceutical Bionanotechnologies' Laboratory, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 050568 Bucharest, Romania.
Safciuc F; 'Medical and Pharmaceutical Bionanotechnologies' Laboratory, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 050568 Bucharest, Romania.
Manduteanu I; 'Medical and Pharmaceutical Bionanotechnologies' Laboratory, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 050568 Bucharest, Romania.
Fundueanu G; Department of Natural Polymers, Bioactive and Biocompatible Materials, 'Petru Poni' Institute of Macromolecular Chemistry, 700487 Iassy, Romania.
Simionescu M; 'Medical and Pharmaceutical Bionanotechnologies' Laboratory, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 050568 Bucharest, Romania.
Calin M; 'Medical and Pharmaceutical Bionanotechnologies' Laboratory, Institute of Cellular Biology and Pathology 'Nicolae Simionescu' of the Romanian Academy, 050568 Bucharest, Romania. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 604-619. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Biomimetic Materials/*chemistry
Carcinoma, Hepatocellular/*metabolism
Cisplatin/*pharmacology
Hyaluronic Acid/*chemistry
Liver Neoplasms/*metabolism
Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/drug therapy ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cholesterol 7-alpha-Hydroxylase/metabolism ; Cisplatin/chemistry ; Drug Screening Assays, Antitumor ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Tissue Scaffolds
Czasopismo naukowe
Tytuł :
Enhancement of interferon gamma stability as an anticancer therapeutic protein against hepatocellular carcinoma upon interaction with calycosin.
Autorzy :
Yang H; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China. Electronic address: .
Khan S; Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
Sun A; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China.
Bai Q; Department of Anesthesiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China. Electronic address: .
Cheng H; Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China.
Akhtari K; Department of Physics, University of Kurdistan, Sanandaj, Iran.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 813-820. Date of Electronic Publication: 2021 Jun 27.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carcinoma, Hepatocellular/*metabolism
Caspase 3/*metabolism
Caspase 9/*metabolism
Interferon-gamma/*pharmacology
Isoflavones/*chemistry
Liver Neoplasms/*metabolism
Antineoplastic Agents/chemistry ; Carcinoma, Hepatocellular/drug therapy ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Stability ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Humans ; Interferon-gamma/chemistry ; Liver Neoplasms/drug therapy ; Protein Folding/drug effects ; Thermodynamics
Czasopismo naukowe
Tytuł :
Cytotoxic effect of xyloglucan and oxovanadium (IV/V) xyloglucan complex in HepG2 cells.
Autorzy :
Escaliante LADS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Busato B; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Petkowicz CLO; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Cadena SMSC; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Noleto GR; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, PR, Brazil. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 40-48. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carcinoma, Hepatocellular/*metabolism
Fabaceae/*chemistry
Glucans/*pharmacology
Liver Neoplasms/*metabolism
Vanadates/*chemistry
Xylans/*pharmacology
Antineoplastic Agents/chemistry ; Carcinoma, Hepatocellular/drug therapy ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Glucans/chemistry ; Hep G2 Cells ; Humans ; L-Lactate Dehydrogenase/metabolism ; Liver Neoplasms/drug therapy ; Membrane Potential, Mitochondrial/drug effects ; Multienzyme Complexes/metabolism ; NADH, NADPH Oxidoreductases/metabolism ; Oxidative Phosphorylation/drug effects ; Oxidoreductases/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Xylans/chemistry
Czasopismo naukowe
Tytuł :
Novel quercetin encapsulated chitosan functionalized copper oxide nanoparticles as anti-breast cancer agent via regulating p53 in rat model.
Autorzy :
Elsayed AM; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Sherif NM; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Hassan NS; Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Althobaiti F; Department of Biotechnology, Collage of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia. Electronic address: .
Hanafy NAN; Nanomedicine group, Institute of Nanoscience and Nanotechnology, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt. Electronic address: .
Sahyon HA; Chemistry Department, Faculty of Science, Kafrelsheikh University, Kafrelsheikh 33516, Egypt. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 31; Vol. 185, pp. 134-152. Date of Electronic Publication: 2021 Jun 17.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Breast Neoplasms/*drug therapy
Chitosan/*chemistry
Copper/*chemistry
Quercetin/*administration & dosage
Tumor Suppressor Protein p53/*metabolism
9,10-Dimethyl-1,2-benzanthracene/adverse effects ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/chemically induced ; Breast Neoplasms/metabolism ; Caco-2 Cells ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Compounding ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Metal Nanoparticles ; Proliferating Cell Nuclear Antigen/metabolism ; Quercetin/chemistry ; Quercetin/pharmacology ; Rats ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Autorzy :
Zhao Y; College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Lu J; College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.; Key Laboratory of Zoonosis, Ministry of Education College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Mao A; College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Zhang R; College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Guan S; College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.; Key Laboratory of Zoonosis, Ministry of Education College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, People's Republic of China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Aug 25; Vol. 69 (33), pp. 9671-9683. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Ferroptosis*
NF-E2-Related Factor 2*/genetics
NF-E2-Related Factor 2*/metabolism
Autophagy ; Hep G2 Cells ; Humans ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Oxidative Stress ; Sequestosome-1 Protein/genetics ; Sequestosome-1 Protein/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart.
Autorzy :
Ahmed DE; Department of Biochemistry, Misr University for Science & Technology (MUST), Giza, Egypt.
Rashidi FB; Biochemistry Lab.Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. .
Abdelhakim HK; Biochemistry Lab.Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
Mohamed AS; Biochemistry Lab.Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
Arafa HMM; Department of Pharmacology and Toxicology, Faculty of Pharmacy Ahram Canadian University, Giza, 267119, Egypt.
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Źródło :
Journal of the Egyptian National Cancer Institute [J Egypt Natl Canc Inst] 2021 Aug 23; Vol. 33 (1), pp. 22. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji :
Journal Article
MeSH Terms :
Ifosfamide*/analogs & derivatives
Liver Neoplasms*/drug therapy
Liver Neoplasms*/genetics
Glucose/analogs & derivatives ; Hep G2 Cells ; Humans
Czasopismo naukowe

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