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Tytuł:
Combination of ethyl acetate fraction from Calotropis gigantea stem bark and sorafenib induces apoptosis in HepG2 cells.
Autorzy:
Chaisupasakul P; Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.
Pekthong D; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.; Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.; Center of Excellence for Environmental Health and Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
Wangteeraprasert A; Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.
Kaewkong W; Department of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
Somran J; Department of Pathology, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.
Kaewpaeng N; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.; Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
Parhira S; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.; Center of Excellence for Environmental Health and Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.
Srisawang P; Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.; Center of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
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Źródło:
PloS one [PLoS One] 2024 Mar 25; Vol. 19 (3), pp. e0300051. Date of Electronic Publication: 2024 Mar 25 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Calotropis*/metabolism
Liver Neoplasms*/drug therapy
Liver Neoplasms*/metabolism
Acetates*
Humans ; Sorafenib/pharmacology ; Sorafenib/therapeutic use ; Proto-Oncogene Proteins c-akt/metabolism ; Hep G2 Cells ; Phosphatidylinositol 3-Kinases/metabolism ; Reactive Oxygen Species/metabolism ; Plant Bark/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Apoptosis ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluation on the Potential for Hepatotoxic Components from Herba Epimedii to Induce Apoptosis in HepG2 Cells and the Analysis of the Influence of Metabolism in Liver Microsomes.
Autorzy:
Zhang L; Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100013, China.
Zhang C; Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100013, China.
Peng X; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100013, China.
Guo Z; Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100013, China.
Yang S; Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100013, China.
Fu D; Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100013, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Mar 19; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:
Journal Article
MeSH Terms:
Microsomes, Liver*
Chemical and Drug Induced Liver Injury*
Drugs, Chinese Herbal*
Humans ; Hep G2 Cells ; Tandem Mass Spectrometry ; Flavonoids/pharmacology ; Flavonoids/analysis ; Apoptosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activation of AMPK pathway by low‑dose donafenib and atorvastatin combination improves high‑fat diet‑induced metabolic dysfunction‑associated steatotic liver disease.
Autorzy:
Bai Y; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Chen K; Department of Gastroenterology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Liu J; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Wang Y; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Wang C; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Ju S; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Zhou C; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Yao W; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
Xiong B; Department of Interventional Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
Zheng C; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2024 Mar; Vol. 29 (3). Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/etiology
Non-alcoholic Fatty Liver Disease*/complications
Metabolic Diseases*/complications
Pyridines*
Rats ; Animals ; Humans ; AMP-Activated Protein Kinases/metabolism ; Atorvastatin/pharmacology ; Atorvastatin/therapeutic use ; Reactive Oxygen Species/metabolism ; Diet, High-Fat/adverse effects ; Liver/metabolism ; Lipid Metabolism ; Hep G2 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comprehensive Transcriptome Profiling of Antioxidant Activities by Glutathione in Human HepG2 Cells.
Autorzy:
Uchida Y; Research and Development Division, Mitsubishi Corporation Life Sciences Ltd., 1-1-3 Yurakucho, Tokyo 100-0006, Japan.
Ferdousi F; Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.; Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba 305-8572, Japan.; Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMed-OIL), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8577, Japan.
Takahashi S; Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.; Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba 305-8572, Japan.
Isoda H; Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan.; Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tsukuba 305-8572, Japan.; Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMed-OIL), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8577, Japan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 29; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Antioxidants*/pharmacology
Phosphatidylinositol 3-Kinases*/metabolism
Humans ; Hep G2 Cells ; Glutathione/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Gene Expression Profiling ; Hydrogen Peroxide/pharmacology ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hepa-ToxMOA: a pathway-screening method for evaluating cellular stress and hepatic metabolic-dependent toxicity of natural products.
Autorzy:
Park SM; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea.; College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 34131, Daejeon, Republic of Korea.
Choi MS; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea.; College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 34131, Daejeon, Republic of Korea.
Kim S; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea.
Jegal H; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea.; Department of Human and Environmental Toxicology, University of Science & Technology, 34113, Daejeon, Republic of Korea.
Han HY; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea.; Department of Human and Environmental Toxicology, University of Science & Technology, 34113, Daejeon, Republic of Korea.
Chun HS; Food Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, 17546, Anseong, South Korea.
Kim SK; College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, 34131, Daejeon, Republic of Korea. .
Oh JH; Department of Predictive Toxicology, Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, 34114, Daejeon, Republic of Korea. .; Department of Human and Environmental Toxicology, University of Science & Technology, 34113, Daejeon, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 21; Vol. 14 (1), pp. 4319. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
NF-kappa B*/metabolism
Gene Expression Regulation*
Humans ; Hep G2 Cells ; Green Fluorescent Proteins/metabolism ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells.
Autorzy:
Castillejo-López C; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 08 , Uppsala, Sweden, Box 815, Husargatan 3, BMC.
Bárcenas-Walls JR; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 08 , Uppsala, Sweden, Box 815, Husargatan 3, BMC.
Cavalli M; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 08 , Uppsala, Sweden, Box 815, Husargatan 3, BMC.
Larsson A; Department of Medical Sciences, Clinical Chemistry, Uppsala University Hospital, 751 85, Uppsala, Sweden.
Wadelius C; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 751 08 , Uppsala, Sweden, Box 815, Husargatan 3, BMC. .
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2024 Feb 16; Vol. 23 (1), pp. 48. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/genetics
Non-alcoholic Fatty Liver Disease*/metabolism
Humans ; Cholesterol, LDL/genetics ; Genome-Wide Association Study ; Hep G2 Cells ; Promoter Regions, Genetic/genetics ; Transcription Factors/genetics ; Triglycerides/metabolism ; Iodide Peroxidase/genetics ; Cholesterol, HDL/genetics ; Cholesterol, HDL/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tea seed saponin‑reduced extract ameliorates palmitic acid‑induced insulin resistance in HepG2 cells.
Autorzy:
Cho SC; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, R.O.C.
Shaw SY; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, R.O.C.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2024 Feb; Vol. 29 (2). Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin Resistance*/physiology
Saponins*/pharmacology
Humans ; Hep G2 Cells ; Palmitic Acid/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Insulin/metabolism ; Glucose/metabolism ; Seeds ; Tea
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Overexpression of salusin‑β downregulates adipoR1 expression to prevent fatty acid oxidation in HepG2 cells.
Autorzy:
Xu A; Department of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China.
Wang L; Department of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China.
Luo M; Department of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China.
Zhang H; Department of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China.
Ning M; Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang 154007, P.R. China.
Pan J; Department of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China.
Duan X; Clinical Laboratory, Ezhou Central Hospital, Ezhou, Hubei 436000, P.R. China.
Wang Y; Department of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China.
Liu X; Department of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2024 Feb; Vol. 29 (2). Date of Electronic Publication: 2023 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
AMP-Activated Protein Kinases*/metabolism
Lipid Metabolism*
Receptors, Adiponectin*/genetics
Receptors, Adiponectin*/metabolism
Humans ; Fatty Acids, Nonesterified/metabolism ; Hep G2 Cells ; Liver/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ZNF148 inhibits HBV replication by downregulating RXRα transcription.
Autorzy:
Yao X; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Xu K; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Tao N; Department of Clinical Laboratory, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.; Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
Cheng S; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Chen H; Department of Clinical Laboratory, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.
Zhang D; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Yang M; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Tan M; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Yu H; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Chen P; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Zhan Z; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
He S; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Li R; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Wang C; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China.
Wu D; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China. .
Ren J; The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chong Yi Building, 1 YiXueYuan Road, Yuzhong District, Chongqing, 400016, China. .
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Źródło:
Virology journal [Virol J] 2024 Jan 31; Vol. 21 (1), pp. 35. Date of Electronic Publication: 2024 Jan 31.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatitis B virus*/physiology
Hepatitis B*
Animals ; Mice ; Humans ; Virus Replication ; Hep G2 Cells ; Transcription Factors/genetics ; Transcription Factors/metabolism ; DNA, Viral/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The 75-99 C-Terminal Peptide of URG7 Protein Promotes α-Synuclein Disaggregation.
Autorzy:
Dandurand J; CIRIMAT Physique des Polymères, Université Toulouse 3, Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse, France.
Monné M; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Samouillan V; CIRIMAT Physique des Polymères, Université Toulouse 3, Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse, France.
Rosa M; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Laurita A; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Pistone A; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Bisaccia D; IRCCS Istituto Tumori 'Giovanni Paolo II' of Bari, 70124 Bari, Italy.
Matera I; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Bisaccia F; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Ostuni A; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 17; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 17.
Typ publikacji:
Journal Article
MeSH Terms:
alpha-Synuclein*/genetics
Peptides*/pharmacology
Multidrug Resistance-Associated Proteins*/genetics
Bridged-Ring Compounds ; Endoplasmic Reticulum ; Pseudogenes ; Humans ; Hep G2 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High-Voltage Electrostatic Field Hydrogel Microsphere 3D Culture System Improves Viability and Liver-like Properties of HepG2 Cells.
Autorzy:
Liu Y; School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.; The CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Ge Y; The CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Wu Y; School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.; The CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Feng Y; The CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Liu H; The CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Cao W; The CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Xie J; The CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
Zhang J; School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.; The CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.; School of Medical Imaging, Xuzhou Medical University, Xuzhou 221004, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 16; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 16.
Typ publikacji:
Journal Article
MeSH Terms:
Hydrogels*/pharmacology
Liver*
Humans ; Microspheres ; Hep G2 Cells ; Static Electricity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of a β-Carboline Alkaloid from Chemoselectively Derived Vanilla Bean Extract and Its Prevention of Lipid Droplet Accumulation in Human Hepatocytes (HepG2).
Autorzy:
Dibwe DF; Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-Ku, Sapporo 060-0812, Japan.
Takeishi N; Graduate School of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-Ku, Sapporo 060-0812, Japan.
Oba S; Graduate School of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-Ku, Sapporo 060-0812, Japan.
Sakurai A; Graduate School of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-Ku, Sapporo 060-0812, Japan.
Sakurai T; Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-Ku, Sapporo 060-0812, Japan.
Tsukui T; Department of Nutrition, Sapporo University of Health Sciences, Nakanuma Nishi-4-3-1-15, Higashi-Ku, Sapporo 007-0894, Japan.
Chiba H; Department of Nutrition, Sapporo University of Health Sciences, Nakanuma Nishi-4-3-1-15, Higashi-Ku, Sapporo 007-0894, Japan.
Hui SP; Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-Ku, Sapporo 060-0812, Japan.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Dec 09; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
Vanilla*/chemistry
Alkaloids*/pharmacology
Humans ; Chromatography, Liquid ; Lipid Droplets ; Tandem Mass Spectrometry ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Hep G2 Cells ; Carbolines/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tigecycline causes loss of cell viability mediated by mitochondrial OXPHOS and RAC1 in hepatocellular carcinoma cells.
Autorzy:
Koch DT; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.; Transplantation Center Munich, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.; Liver Center Munich, Ludwig-Maximilians-University Munich, Munich, Germany.
Yu H; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.
Beirith I; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.
Schirren M; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.; Transplantation Center Munich, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.; Liver Center Munich, Ludwig-Maximilians-University Munich, Munich, Germany.
Drefs M; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.; Transplantation Center Munich, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.; Liver Center Munich, Ludwig-Maximilians-University Munich, Munich, Germany.
Liu Y; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.
Knoblauch M; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.
Koliogiannis D; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.; Transplantation Center Munich, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.; Liver Center Munich, Ludwig-Maximilians-University Munich, Munich, Germany.
Sheng W; Department of Gastrointestinal Surgery, The First Hospital, China Medical University, Shenyang, 110001, China.
De Toni EN; Liver Center Munich, Ludwig-Maximilians-University Munich, Munich, Germany.; Department of Internal Medicine II, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
Bazhin AV; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.; German Cancer Consortium (DKTK), DKTK Partner Site Munich, Munich, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.
Renz BW; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.; German Cancer Consortium (DKTK), DKTK Partner Site Munich, Munich, Germany.; Transplantation Center Munich, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.; Liver Center Munich, Ludwig-Maximilians-University Munich, Munich, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.
Guba MO; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.; Transplantation Center Munich, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.; Liver Center Munich, Ludwig-Maximilians-University Munich, Munich, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.
Werner J; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.; German Cancer Consortium (DKTK), DKTK Partner Site Munich, Munich, Germany.; Transplantation Center Munich, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.; Liver Center Munich, Ludwig-Maximilians-University Munich, Munich, Germany.; Bavarian Cancer Research Center (BZKF), Munich, Germany.
Ilmer M; Department of General, Visceral and Transplantation Surgery, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany. .; German Cancer Consortium (DKTK), DKTK Partner Site Munich, Munich, Germany. .; Transplantation Center Munich, LMU University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany. .; Liver Center Munich, Ludwig-Maximilians-University Munich, Munich, Germany. .; Bavarian Cancer Research Center (BZKF), Munich, Germany. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Dec 02; Vol. 21 (1), pp. 876. Date of Electronic Publication: 2023 Dec 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/genetics
Neoplastic Cells, Circulating*/metabolism
Humans ; Tigecycline/pharmacology ; Tigecycline/metabolism ; Tigecycline/therapeutic use ; Reactive Oxygen Species/metabolism ; Cell Survival ; Cell Proliferation/genetics ; Hep G2 Cells ; Mitochondria/metabolism ; Cell Line ; Cell Line, Tumor ; Apoptosis ; Gene Expression Regulation, Neoplastic ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism ; rac1 GTP-Binding Protein/pharmacology
Czasopismo naukowe
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Tytuł:
Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors.
Autorzy:
El-Kalyoubi S; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
El-Sebaey SA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Rashad AM; Accelerator and Ion Sources Department, Nuclear Research Center, Atomic Energy Authority, Cairo, Egypt.; Central Lab for Elemental and Isotopic Analysis, NRC, Atomic Energy Authority, Cairo, Egypt.
Al-Ghulikah HA; Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Ghorab MM; Department of Drug Radiation Research, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Elfeky SM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2198163.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines*/chemical synthesis
Pyrimidines*/pharmacology
Topoisomerase II Inhibitors*/chemical synthesis
Topoisomerase II Inhibitors*/pharmacology
HSP90 Heat-Shock Proteins*/antagonists & inhibitors
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/pharmacology
Hep G2 Cells ; A549 Cells ; MCF-7 Cells ; Humans ; Cell Proliferation/drug effects ; Gene Expression Regulation/drug effects ; Cell Cycle/drug effects ; Computer Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Andrographolide nanophytosomes exhibit enhanced cellular delivery and pro-apoptotic activities in HepG2 liver cancer cells.
Autorzy:
Neamatallah T; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Malebari AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Alamoudi AJ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Nazreen S; Department of Chemistry, Faculty of Science, Albaha University, Albaha, Saudi Arabia.
Alam MM; Department of Chemistry, Faculty of Science, Albaha University, Albaha, Saudi Arabia.
Bin-Melaih HH; Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Abuzinadah OA; Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Badr-Eldin SM; Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Alhassani G; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Makki L; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Nasrullah MZ; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
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Źródło:
Drug delivery [Drug Deliv] 2023 Dec; Vol. 30 (1), pp. 2174209.
Typ publikacji:
Journal Article
MeSH Terms:
Diterpenes*/pharmacology
Liver Neoplasms*/drug therapy
Humans ; Hep G2 Cells ; Cell Proliferation ; Apoptosis ; G2 Phase Cell Cycle Checkpoints
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells.
Autorzy:
Sakao K; The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890-0065, Japan.; Department of Food Science and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan.
Saruwatari H; Department of Food Science and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan.
Minami S; Department of Food Science and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan.
Hou DX; The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890-0065, Japan.; Department of Food Science and Biotechnology, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 23; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Quercetin*/pharmacology
Quercetin*/metabolism
Apoptosis*
Humans ; Hep G2 Cells ; Reactive Oxygen Species/metabolism ; Acetylation ; Flavonoids/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Regulator Role for the ATP-Binding Cassette Subfamily C Member 6 Transporter in HepG2 Cells: Effect on the Dynamics of Cell-Cell and Cell-Matrix Interactions.
Autorzy:
Matera I; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Miglionico R; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Abruzzese V; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Marchese G; Genomix4Life Srl, 84081 Baronissi, Italy.; Genome Research Center for Health-CRGS, 84081 Baronissi, Italy.
Ventola GM; Genomix4Life Srl, 84081 Baronissi, Italy.
Castiglione Morelli MA; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Bisaccia F; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
Ostuni A; Department of Sciences, University of Basilicata, 85100 Potenza, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 16; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Humans ; Hep G2 Cells ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Adenosine Triphosphate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of FTY720P on lipid accumulation in HEPG2 cells.
Autorzy:
Rida R; Department of Biology, Faculty of Arts & Sciences, American University of Beirut, Beirut, Lebanon.
Kreydiyyeh S; Department of Biology, Faculty of Arts & Sciences, American University of Beirut, Beirut, Lebanon. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 12; Vol. 13 (1), pp. 19716. Date of Electronic Publication: 2023 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/metabolism
Humans ; Hep G2 Cells ; Sterol Regulatory Element Binding Protein 1/metabolism ; PPAR gamma/metabolism ; Liver/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Lipid Metabolism ; Lysophospholipids/pharmacology ; Lysophospholipids/metabolism ; Phosphatidylinositol 3-Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Composition of Polygonatum zanlanscianense Pamp. Steam and Leaf Phenolic Extract and Its Protective Mechanism on t-BHP-Induced Oxidative Damage of HepG2 Cells.
Autorzy:
Tang S; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yong J; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yan J; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Peng T; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Long F; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Chen H; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Nov 08; Vol. 28 (22). Date of Electronic Publication: 2023 Nov 08.
Typ publikacji:
Journal Article
MeSH Terms:
Polygonatum*
Humans ; Kelch-Like ECH-Associated Protein 1/metabolism ; Steam ; NF-E2-Related Factor 2/metabolism ; Hep G2 Cells ; Oxidative Stress ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Reactive Oxygen Species/metabolism ; Glutathione/metabolism ; Phenols/pharmacology ; Heme Oxygenase-1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Formaldehyde regulates S -adenosylmethionine biosynthesis and one-carbon metabolism.
Autorzy:
Pham VN; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Bruemmer KJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Toh JDW; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Ge EJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Tenney L; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Ward CC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Dingler FA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Millington CL; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Garcia-Prieto CA; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.; Life Sciences Department, Barcelona Supercomputing Center (BSC), Barcelona, Spain.
Pulos-Holmes MC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Ingolia NT; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Pontel LB; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.; Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA), CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina.
Esteller M; Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.; Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Calle Monforte de Lemos, Madrid, Spain.; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Passeig de Lluis Companys, Barcelona, Spain.; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona, Feixa Llarga, l'Hospitalet de Llobregat, Spain.
Patel KJ; MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Nomura DK; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, Berkeley, CA 94704, USA.
Chang CJ; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Nov 03; Vol. 382 (6670), pp. eabp9201. Date of Electronic Publication: 2023 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Carbon*/metabolism
Epigenesis, Genetic*/drug effects
S-Adenosylmethionine*/antagonists & inhibitors
S-Adenosylmethionine*/metabolism
Formaldehyde*/metabolism
Formaldehyde*/toxicity
Methionine Adenosyltransferase*/antagonists & inhibitors
Methionine Adenosyltransferase*/genetics
Methionine Adenosyltransferase*/metabolism
Cysteine*/metabolism
Animals ; Mice ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Environmental Exposure ; Humans ; Hep G2 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 5439

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