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Wyszukujesz frazę ""Hepatocyte Nuclear Factor 1-alpha"" wg kryterium: Temat


Tytuł:
Feedback loop between hepatocyte nuclear factor 1α and endoplasmic reticulum stress mitigates liver injury by downregulating hepatocyte apoptosis.
Autorzy:
Liu SY; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi, 563000, Guizhou, China.
Rao JX; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi, 563000, Guizhou, China.
Deng J; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi, 563000, Guizhou, China.
Zhang GJ; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi, 563000, Guizhou, China.
Jiang XL; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi, 563000, Guizhou, China.
Cheng J; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi, 563000, Guizhou, China.
Chen H; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi, 563000, Guizhou, China.
Jiang ZG; School of Public Health, Zunyi Medical University, Zunyi, 563099, Guizhou, China.
Xu DL; Cell Biology Department, Zunyi Medical University, Zunyi, 563099, Guizhou, China.
He YH; Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 201 Dalian Street, Zunyi, 563000, Guizhou, China. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jul 08; Vol. 12 (1), pp. 11602. Date of Electronic Publication: 2022 Jul 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endoplasmic Reticulum Stress*/physiology
Hepatocyte Nuclear Factor 1-alpha*/metabolism
Activating Transcription Factor 4/metabolism ; Animals ; Apoptosis ; Feedback ; Hepatocytes/metabolism ; Humans ; Lipopolysaccharides/metabolism ; Liver/metabolism ; Mice ; NF-kappa B/metabolism
Czasopismo naukowe
Tytuł:
Insights from basic adjunctive examinations of GCK-MODY, HNF1A-MODY, and type 2 diabetes: A systemic review and meta-analysis.
Autorzy:
Liu J; Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Xiao X; Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Zhang Q; Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Yu M; Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
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Źródło:
Journal of diabetes [J Diabetes] 2023 Jun; Vol. 15 (6), pp. 519-531. Date of Electronic Publication: 2023 May 24.
Typ publikacji:
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms:
Diabetes Mellitus, Type 2*/diagnosis
Diabetes Mellitus, Type 2*/genetics
Female ; Humans ; Pregnancy ; C-Reactive Protein ; Glucokinase/genetics ; Glucose ; Glycated Hemoglobin ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Mutation ; Triglycerides
SCR Disease Name:
Mason-Type Diabetes
Czasopismo naukowe
Tytuł:
HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1.
Autorzy:
Fujino S; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita-City, Osaka, 565-0871, Japan.; Innovative Oncology Research and Translational Medicine, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Miyoshi N; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita-City, Osaka, 565-0871, Japan. .; Innovative Oncology Research and Translational Medicine, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, 541-8567, Japan. .
Ito A; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita-City, Osaka, 565-0871, Japan.
Yasui M; Department of Surgery, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Matsuda C; Department of Surgery, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Ohue M; Department of Surgery, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Uemura M; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita-City, Osaka, 565-0871, Japan.
Mizushima T; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita-City, Osaka, 565-0871, Japan.
Doki Y; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita-City, Osaka, 565-0871, Japan.
Eguchi H; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita-City, Osaka, 565-0871, Japan.
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Źródło:
Scientific reports [Sci Rep] 2021 May 14; Vol. 11 (1), pp. 10363. Date of Electronic Publication: 2021 May 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Colorectal Neoplasms/*genetics
Drug Resistance, Neoplasm/*genetics
Hepatocyte Nuclear Factor 1-alpha/*genetics
Octamer Transcription Factor-3/*metabolism
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Chemotherapy, Adjuvant ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Disease Progression ; Disease-Free Survival ; Female ; Follow-Up Studies ; Gene Knockdown Techniques ; Glucose Transporter Type 1/genetics ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Humans ; Male ; Mice ; Middle Aged ; Primary Cell Culture ; Xenograft Model Antitumor Assays ; Young Adult
Czasopismo naukowe
Tytuł:
Four Cases of Maturity Onset Diabetes of the Young (MODY) Type 5 Associated with Mutations in the Hepatocyte Nuclear Factor 1 Beta (HNF1B) Gene Presenting in a 13-Year-Old Boy and in Adult Men Aged 33, 34, and 35 Years in Poland.
Autorzy:
Motyka R; University of Zielona Góra, Zielona Góra, Poland.
Kołbuc M; Department of Pediatrics, University of Zielona Góra, Zielona Góra, Poland.
Wierzchołowski W; Department of Radiology, Univiersity of Zielona Góra, Zielona Góra, Poland.
Beck BB; Institute of Human Genetics and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Towpik IE; Department of Internal Medicine, Univiersity of Zielona Góra, Zielona Góra, Poland.
Zaniew M; Department of Pediatrics, Univiersity of Zielona Góra, Zielona Góra, Poland.
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Źródło:
The American journal of case reports [Am J Case Rep] 2021 Feb 02; Vol. 22, pp. e928994. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/genetics
Hepatocyte Nuclear Factor 1-alpha*/genetics
Adolescent ; Adult ; Hepatocyte Nuclear Factor 1-beta/genetics ; Humans ; Male ; Mutation ; Poland
SCR Disease Name:
Mason-Type Diabetes
Czasopismo naukowe
Tytuł:
De novo HNF1A mutation of young maturity-onset diabetes 3 of a young girl-Case report.
Autorzy:
Peng H; Chengdu Medical College, 610083, Chengdu, China.
Li J; Southwest Medical University, 646000, Luzhou, China.
Wang Z; Department of Geriatrics, The General Hospital of Western Theater Command, 610083, Chengdu, China. .
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Źródło:
BMC endocrine disorders [BMC Endocr Disord] 2023 Feb 14; Vol. 23 (1), pp. 38. Date of Electronic Publication: 2023 Feb 14.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/diagnosis
Female ; Humans ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Insulin/genetics ; Mutation ; Child
SCR Disease Name:
Maturity-Onset Diabetes of the Young, Type 3
Czasopismo naukowe
Tytuł:
Transcriptome analysis uncovers the diagnostic value of miR-192-5p/HNF1A-AS1/VIL1 panel in cervical adenocarcinoma.
Autorzy:
Xu J; Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China. .
Zou J; Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
Wu L; Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
Lu W; Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China. .; Center of Uterine Cancer Diagnosis & Therapy of Zhejiang Province, Hangzhou, 310006, Zhejiang, China. .
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Źródło:
Scientific reports [Sci Rep] 2020 Oct 06; Vol. 10 (1), pp. 16584. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenocarcinoma/*diagnosis
Biomarkers, Tumor/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Hepatocyte Nuclear Factor 1-alpha/*genetics
Microfilament Proteins/*genetics
Receptors, Somatostatin/*genetics
Uterine Cervical Neoplasms/*diagnosis
Adenocarcinoma/genetics ; Biomarkers, Tumor/metabolism ; Female ; Gene Expression ; Gene Expression Profiling ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Microfilament Proteins/metabolism ; Receptors, Somatostatin/metabolism ; Uterine Cervical Neoplasms/genetics
Czasopismo naukowe
Tytuł:
Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation.
Autorzy:
Zhao M; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Kiernan CH; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Stairiker CJ; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hope JL; Cancer Immunology and Tumor Microenvironment Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States of America.
Leon LG; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
van Meurs M; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Brouwers-Haspels I; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Boers R; Department of Developmental Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Oncode Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
Boers J; Department of Developmental Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Oncode Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
Gribnau J; Department of Developmental Biology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Oncode Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
van IJcken WFJ; Center for Biomics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Bindels EM; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hoogenboezem RM; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Erkeland SJ; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Mueller YM; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Katsikis PD; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.
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Źródło:
PLoS pathogens [PLoS Pathog] 2020 Jun 24; Vol. 16 (6), pp. e1008555. Date of Electronic Publication: 2020 Jun 24 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD8-Positive T-Lymphocytes/*immunology
DNA Methylation/*immunology
Hepatocyte Nuclear Factor 1-alpha/*immunology
Lymphocytic Choriomeningitis/*immunology
Lymphocytic choriomeningitis virus/*immunology
Promoter Regions, Genetic/*immunology
Animals ; CD8-Positive T-Lymphocytes/pathology ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Lymphocytic Choriomeningitis/genetics ; Lymphocytic Choriomeningitis/pathology ; Lymphocytic choriomeningitis virus/genetics ; Mice ; Mice, Transgenic ; Signal Transduction/genetics ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł:
Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a.
Autorzy:
Cui CJ; Faculty of Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
Jin JL; Faculty of Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
Guo LN; Faculty of Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
Sun J; Faculty of Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
Wu NQ; Faculty of Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
Guo YL; Faculty of Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
Liu G; Faculty of Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
Dong Q; Faculty of Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China.
Li JJ; Faculty of Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2020 May 12; Vol. 18 (1), pp. 195. Date of Electronic Publication: 2020 May 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Catechin*/pharmacology
Forkhead Box Protein O3*/antagonists & inhibitors
Forkhead Box Protein O3*/metabolism
Hepatocyte Nuclear Factor 1-alpha*
Proprotein Convertase 9*
Receptors, LDL*
Animals ; Cholesterol, LDL ; Humans ; Rats
Czasopismo naukowe
Tytuł:
The Genetic Spectrum of Maturity-Onset Diabetes of the Young (MODY) in Qatar, a Population-Based Study.
Autorzy:
Elashi AA; College of Health and Life Sciences (CHLS), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha P.O. Box 34110, Qatar.
Toor SM; College of Health and Life Sciences (CHLS), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha P.O. Box 34110, Qatar.
Diboun I; College of Health and Life Sciences (CHLS), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha P.O. Box 34110, Qatar.; Medical and Population Genomics Lab, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Al-Sarraj Y; Qatar Genome Program (QGP), Qatar Foundation Research, Development and Innovation, Qatar Foundation (QF), Doha P.O. Box 5825, Qatar.
Taheri S; Qatar Metabolic Institute, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar.
Suhre K; Bioinformatics Core, Weill Cornell Medicine-Qatar, Education City, Doha P.O. Box 24144, Qatar.; Department of Biophysics and Physiology, Weill Cornell Medicine, New York, NY 10065, USA.
Abou-Samra AB; Qatar Metabolic Institute, Hamad Medical Corporation, Doha P.O. Box 3050, Qatar.
Albagha OME; College of Health and Life Sciences (CHLS), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), Doha P.O. Box 34110, Qatar.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XU, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 21; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Diabetes Mellitus, Type 2*/epidemiology
Diabetes Mellitus, Type 2*/genetics
Humans ; Qatar/epidemiology ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Mutation
SCR Disease Name:
Mason-Type Diabetes
Czasopismo naukowe
Tytuł:
Chromosomally Unstable Gastric Cancers Overexpressing Claudin-6 Disclose Cross-Talk between HNF1A and HNF4A, and Upregulated Cholesterol Metabolism.
Autorzy:
Dwivedi S; Laboratorio de Inmunobiología, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM, Ciudad de México 04510, Mexico.
Hernández-Montes G; Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición 'Dr. Salvador Zubiran', Ciudad de México 14080, Mexico.
Montaño LF; Laboratorio de Inmunobiología, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM, Ciudad de México 04510, Mexico.
Rendón-Huerta EP; Laboratorio de Inmunobiología, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM, Ciudad de México 04510, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 12; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 12.
Typ publikacji:
Journal Article
MeSH Terms:
Stomach Neoplasms*/genetics
Adenocarcinoma*
Humans ; Hepatocyte Nuclear Factor 1-alpha ; Claudins ; Apolipoprotein C-III ; Cholesterol ; Hepatocyte Nuclear Factor 4/genetics ; Neoplasm Proteins ; Intracellular Signaling Peptides and Proteins
Czasopismo naukowe
Tytuł:
Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency.
Autorzy:
González BJ; Naomi Berrie Diabetes Center & Departments of Pediatrics and Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.; Institute of Human Nutrition, Columbia University Medical Center, New York, NY, 10032, USA.
Zhao H; Department of Systems Biology, Columbia University Medical Center, New York, NY, 10032, USA.
Niu J; Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Williams DJ; Stem Cell Core Facility, Department of Rehabilitation and Regenerative Medicine, Columbia University, New York, NY, 10032, USA.
Lee J; Department of Systems Biology, Columbia University Medical Center, New York, NY, 10032, USA.
Goulbourne CN; Center for Dementia Research, Nathan S. Kline Institute, Orangeburg, NY, 10962, USA.
Xing Y; Department of Surgery, University of Virginia, Charlottesville, VA, 22908, USA.
Wang Y; Department of Surgery, University of Virginia, Charlottesville, VA, 22908, USA.
Oberholzer J; Department of Surgery, University of Virginia, Charlottesville, VA, 22908, USA.
Blumenkrantz MH; Naomi Berrie Diabetes Center & Departments of Pediatrics and Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Chen X; Columbia Center for Translational Immunology, Department of Surgery, Columbia University Medical Center, New York, NY, 10032, USA.
LeDuc CA; Naomi Berrie Diabetes Center & Departments of Pediatrics and Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Chung WK; Naomi Berrie Diabetes Center & Departments of Pediatrics and Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Colecraft HM; Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Gromada J; Regeneron Pharmaceuticals, Tarrytown, NY, 10591, USA.; Vertex Cell and Genetic Therapies, Watertown, MA, 02472, USA.
Shen Y; Department of Systems Biology, Columbia University Medical Center, New York, NY, 10032, USA.
Goland RS; Naomi Berrie Diabetes Center & Departments of Pediatrics and Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Leibel RL; Naomi Berrie Diabetes Center & Departments of Pediatrics and Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Egli D; Naomi Berrie Diabetes Center & Departments of Pediatrics and Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA. .
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Źródło:
Communications biology [Commun Biol] 2022 Aug 02; Vol. 5 (1), pp. 779. Date of Electronic Publication: 2022 Aug 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Type 2*/genetics
Insulin*/metabolism
Calcium/metabolism ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Humans ; Insulin, Regular, Human ; Stem Cells/metabolism ; Synaptotagmins
SCR Disease Name:
Mason-Type Diabetes
Czasopismo naukowe
Tytuł:
Liver adenomatosis in patients with hepatocyte nuclear factor-1 alpha maturity onset diabetes of the young (HNF1A-MODY): Clinical, radiological and pathological characteristics in a French series.
Autorzy:
Haddouche A; Department of Endocrinology and Diabetology, Caen University Hospital, Caen, France.
Bellanne-Chantelot C; Department of Genetics, Pitié-Salpetrière Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.
Rod A; Department of Endocrinology and Diabetology, Caen University Hospital, Caen, France.
Fournier L; Department of Radiology, Caen University Hospital, Caen, France.
Chiche L; Department of Hepatobiliary and Pancreatic Surgery, Bordeaux University Hospital, Maison du Haut Lévèque, Bordeaux, France.
Gautier JF; Department of Endocrinology and Diabetology, Saint Louis University Hospital, Paris, France.
Timsit J; Department of Immunology and Diabetology, Cochin University Hospital, Paris, France.
Laboureau S; Department of Endocrinology and Diabetology, Angers University Hospital, Angers, France.
Chaillous L; Department of Endocrinology, Hôtel Dieu University Hospital, Nantes, France.
Valero R; Department of Nutrition and Metabolic Diseases, La Conception Hospital, Marseille, France.
Larger E; Department of Immunology and Diabetology, Cochin University Hospital, Paris, France.
Jeandidier N; Department of Endocrinology, Diabetology and Metabolic Diseases, Leriche Pavillon, Civil Hospital, Strasbourg, France.
Wilhelm JM; Department of Medicine, Saint Morand Hospital, Altkirch, France.
Popelier M; Department of Medicine, Pitié-Salpetrière Hospital, Paris, France.
Guillausseau PJ; Department of Medicine B6, Lariboisière University Hospital, Paris, France.
Thivolet C; Department of Endocrinology and Metabolic Diseases, Debrousse University Hospital, Lyon, France.
Lecomte P; Department of Endocrinology and Diabetology, Bretonneau University Hospital, Tours, France.
Benhamou PY; Department of Diabetology, Endocrinology and Nutrition, Grenoble University Hospital, Grenoble, France.
Reznik Y; Department of Endocrinology and Diabetology, Caen University Hospital, Caen, France.
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Źródło:
Journal of diabetes [J Diabetes] 2020 Jan; Vol. 12 (1), pp. 48-57. Date of Electronic Publication: 2019 Jul 10.
Typ publikacji:
Journal Article; Multicenter Study
MeSH Terms:
Mutation*
Adenoma/*genetics
Diabetes Mellitus, Type 2/*genetics
Hepatocyte Nuclear Factor 1-alpha/*genetics
Liver Neoplasms/*genetics
Adenoma/diagnostic imaging ; Adenoma/pathology ; Adolescent ; Adult ; Child ; Cohort Studies ; Diabetes Mellitus, Type 2/diagnostic imaging ; Diabetes Mellitus, Type 2/pathology ; Diagnostic Imaging/methods ; Family Health ; Female ; France ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Young Adult
SCR Disease Name:
Maturity-Onset Diabetes of the Young, Type 3
Czasopismo naukowe
Tytuł:
The impact of hepatocyte nuclear factor-1α on liver malignancies and cell stemness with metabolic consequences.
Autorzy:
Wang X; Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Hassan W; Department of Pharmacy, COMSATS University Islamabad, Lahore campus, Lahore, Pakistan.
Zhao J; Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Bakht S; Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Nie Y; Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Wang Y; Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University, Wuxi, China.; Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, 214062, Jiangsu, China.
Pang Q; Department of physiopathology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu province, China.
Huang Z; Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University, Wuxi, China. .; Wuxi Cancer Institute, Affiliated Hospital of Jiangnan University, Wuxi, 214062, Jiangsu, China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2019 Nov 04; Vol. 10 (1), pp. 315. Date of Electronic Publication: 2019 Nov 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Hepatocyte Nuclear Factor 1-alpha/*metabolism
Liver Neoplasms/*metabolism
Liver Neoplasms/*pathology
Neoplastic Stem Cells/*metabolism
Neoplastic Stem Cells/*pathology
Animals ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Humans ; Liver/metabolism ; Liver/pathology ; Models, Biological ; Mutation/genetics
Czasopismo naukowe
Tytuł:
Expression of mutant mRNA and protein in pancreatic cells derived from MODY3- iPS cells.
Autorzy:
Yabe SG; Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Nishida J; Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Fukuda S; Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Takeda F; Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Nasiro K; Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Yasuda K; Department of Metabolic Disorders, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
Iwasaki N; Institute of Geriatrics, Diabetes Center, Institute of Medical Genetics, Tokyo Women's Medical University, Tokyo, Japan.
Okochi H; Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
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Źródło:
PloS one [PLoS One] 2019 May 30; Vol. 14 (5), pp. e0217110. Date of Electronic Publication: 2019 May 30 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Diabetes Mellitus, Type 2/*metabolism
Hepatocyte Nuclear Factor 1-alpha/*metabolism
Induced Pluripotent Stem Cells/*pathology
Insulin-Secreting Cells/*pathology
RNA, Messenger/*genetics
Cells, Cultured ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Female ; Haploinsufficiency ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Insulin-Secreting Cells/metabolism ; RNA, Messenger/metabolism
SCR Disease Name:
Maturity-Onset Diabetes of the Young, Type 3
Czasopismo naukowe
Tytuł:
m A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated CCND1 mRNA Stabilization.
Autorzy:
Bian Y; Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Wang Y; Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Xu S; Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Gao Z; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Li C; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Fan Z; Department of Urology, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Ding J; Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Wang K; Department of Oncology, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
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Źródło:
Cells [Cells] 2022 Sep 27; Vol. 11 (19). Date of Electronic Publication: 2022 Sep 27.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Apoptosis Regulatory Proteins ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cyclin D1 ; Gene Expression Regulation, Neoplastic ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Humans ; Methyltransferases/metabolism ; RNA, Messenger ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł:
Hepatocyte Nuclear Factor 1α Proinflammatory Effect Linked to the Overexpression of Liver Nuclear Factor-κB in Experimental Model of Chronic Kidney Disease.
Autorzy:
Sucajtys-Szulc E; Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.
Debska-Slizien A; Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.
Rutkowski B; Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.
Szolkiewicz M; Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.; Department of Cardiology and Interventional Angiology, Kashubian Center for Heart and Vascular Diseases in Wejherowo, Pomeranian Hospitals, 84-200 Wejherowo, Poland.
Swierczynski J; Koszalin State Higher Vocational School, Lesna 1, 75-582 Koszalin, Poland.; Department of Biochemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland.
Smolenski RT; Department of Biochemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 10; Vol. 23 (16). Date of Electronic Publication: 2022 Aug 10.
Typ publikacji:
Journal Article
MeSH Terms:
NF-kappa B*/genetics
NF-kappa B*/metabolism
Renal Insufficiency, Chronic*/genetics
Animals ; Cell Line, Tumor ; Hepatocyte Nuclear Factor 1-alpha ; Humans ; Intercellular Adhesion Molecule-1/metabolism ; Interleukin-6/genetics ; Liver/metabolism ; Models, Theoretical ; RNA, Messenger/metabolism ; Rats ; Transcription Factor RelA/genetics ; Transcription Factor RelA/metabolism ; Vascular Cell Adhesion Molecule-1/genetics ; Vascular Cell Adhesion Molecule-1/metabolism
Czasopismo naukowe
Tytuł:
Transcriptional and Epigenetic Consequences of DMSO Treatment on HepaRG Cells.
Autorzy:
Dubois-Pot-Schneider H; INSERM, Université de Rennes, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000 Rennes, France.
Aninat C; INSERM, Université de Rennes, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000 Rennes, France.
Kattler K; Department of Genetics, University of Saarland (UdS), 66123 Saarbrücken, Germany.
Fekir K; INSERM, Université de Rennes, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000 Rennes, France.
Jarnouen K; INSERM, Université de Rennes, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000 Rennes, France.
Cerec V; INSERM, Université de Rennes, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000 Rennes, France.
Glaise D; INSERM, Université de Rennes, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000 Rennes, France.
Salhab A; Department of Genetics, University of Saarland (UdS), 66123 Saarbrücken, Germany.
Gasparoni G; Department of Genetics, University of Saarland (UdS), 66123 Saarbrücken, Germany.
Takashi K; Division of Pharmacology, National Institute of Health Sciences, Kawasaki-ku, Kawasaki 2109501, Japan.
Ishida S; Division of Pharmacology, National Institute of Health Sciences, Kawasaki-ku, Kawasaki 2109501, Japan.
Walter J; Department of Genetics, University of Saarland (UdS), 66123 Saarbrücken, Germany.
Corlu A; INSERM, Université de Rennes, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000 Rennes, France.
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Źródło:
Cells [Cells] 2022 Jul 26; Vol. 11 (15). Date of Electronic Publication: 2022 Jul 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dimethyl Sulfoxide*/metabolism
Dimethyl Sulfoxide*/pharmacology
Epigenesis, Genetic*
Hepatocytes*/drug effects
Hepatocytes*/metabolism
Hepatocyte Nuclear Factor 1-alpha/metabolism ; Hepatocyte Nuclear Factor 4/metabolism ; Humans ; Liver/metabolism ; PPAR alpha/metabolism
Czasopismo naukowe
Tytuł:
The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α.
Autorzy:
Kaci A; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021, Bergen, Norway.; Department of Medical Genetics, Haukeland University Hospital, 5021, Bergen, Norway.; Department of Pediatrics and Adolescents, Haukeland University Hospital, 5021, Bergen, Norway.
Keindl M; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021, Bergen, Norway.
Solheim MH; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021, Bergen, Norway.
Njølstad PR; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021, Bergen, Norway. .; Department of Pediatrics and Adolescents, Haukeland University Hospital, 5021, Bergen, Norway. .
Bjørkhaug L; Department of Biomedical Laboratory Sciences and Chemical Engineering, Western Norway University of Applied Sciences, 5063, Bergen, Norway.
Aukrust I; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5021, Bergen, Norway. .; Department of Medical Genetics, Haukeland University Hospital, 5021, Bergen, Norway. .
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Źródło:
Scientific reports [Sci Rep] 2018 Aug 24; Vol. 8 (1), pp. 12780. Date of Electronic Publication: 2018 Aug 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus/*metabolism
Hepatocyte Nuclear Factor 1-alpha/*metabolism
Poly-ADP-Ribose Binding Proteins/*metabolism
Protein Inhibitors of Activated STAT/*metabolism
Amino Acid Sequence ; Animals ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cytosol/metabolism ; DNA/metabolism ; Gene Expression Regulation ; HEK293 Cells ; HeLa Cells ; Hepatocyte Nuclear Factor 1-alpha/chemistry ; Hepatocyte Nuclear Factor 1-alpha/genetics ; Humans ; Lysine/metabolism ; Mice ; Promoter Regions, Genetic/genetics ; Protein Binding ; Rats ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Transcriptional Activation/genetics
Czasopismo naukowe
Tytuł:
Tentatively Identified (UPLC/T-TOF-MS/MS) Compounds in the Extract of Saussurea costus Roots Exhibit In Vivo Hepatoprotection via Modulation of HNF-1α, Sirtuin-1, C/ebpα, miRNA-34a and miRNA-223.
Autorzy:
El Gizawy HA; Department of Pharmacognosy, Faculty of Pharmacy, October 6 University (O6U), Giza 12585, Egypt.
El-Haddad AE; Department of Pharmacognosy, Faculty of Pharmacy, October 6 University (O6U), Giza 12585, Egypt.
Saadeldeen AM; Department of Pharmacognosy, School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo-Alexandria Desert Road, Giza 12577, Egypt.
Boshra SA; Department of Biochemistry, Faculty of Pharmacy, October 6 University (O6U), Giza 12585, Egypt.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Apr 28; Vol. 27 (9). Date of Electronic Publication: 2022 Apr 28.
Typ publikacji:
Journal Article
MeSH Terms:
MicroRNAs*/genetics
MicroRNAs*/metabolism
Saussurea*/chemistry
Animals ; Antioxidants/metabolism ; Antioxidants/pharmacology ; CCAAT-Enhancer-Binding Protein-alpha/metabolism ; Caspase 2/metabolism ; Catalase/metabolism ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Interleukin-6/metabolism ; Plant Extracts/chemistry ; Plant Roots ; Rats ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Tandem Mass Spectrometry ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł:
Maturity onset diabetes of the young due to HNF1A variants in Croatia.
Autorzy:
Pavić T; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Juszczak A; Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Pape Medvidović E; Vuk Vrhovac University Clinic, Merkur University Hospital, Zagreb, Croatia.
Burrows C; Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Šekerija M; Croatian Institute of Public Health, Zagreb, Croatia.; School of Medicine, Andrija Štampar School of Public Health, University of Zagreb, Zagreb, Croatia.
Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Ćuća Knežević J; Department of Clinical Chemistry and Laboratory Medicine, Merkur University Hospital, Zagreb, Croatia.
Gloyn AL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, Oxford, UK.
Lauc G; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.; Genos Ltd, Glycobiology Division, Zagreb, Croatia.
McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, Oxford, UK.
Gornik O; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
Owen KR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
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Źródło:
Biochemia medica [Biochem Med (Zagreb)] 2018 Jun 15; Vol. 28 (2), pp. 020703. Date of Electronic Publication: 2018 Apr 15.
Typ publikacji:
Journal Article
MeSH Terms:
Mutation*
Registries*
C-Peptide/*blood
Diabetes Mellitus, Type 2/*diagnosis
Diabetes Mellitus, Type 2/*epidemiology
Hepatocyte Nuclear Factor 1-alpha/*genetics
Adolescent ; Adult ; Aged ; Alleles ; Autoantibodies/blood ; Biomarkers/blood ; Croatia/epidemiology ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/genetics ; Female ; Gene Expression ; Gene Frequency ; Genetic Testing ; Hepatocyte Nuclear Factor 1-alpha/immunology ; Humans ; Insulin-Secreting Cells/immunology ; Insulin-Secreting Cells/pathology ; Male ; Middle Aged ; Prevalence ; Sequence Analysis, DNA
Czasopismo naukowe

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