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Wyszukujesz frazę ""Hepatocytes"" wg kryterium: Temat


Tytuł :
A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes.
Autorzy :
Yamamoto C; Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University.
Takemura A; Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University.
Ishii S; Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University.
Doi A; Shinko Chemical Co., Ltd.
Saito I; Shinko Chemical Co., Ltd.
Yamada H; Shinko Chemical Co., Ltd.
Sakai Y; Department of Clinical Pharmacy, Graduate School and Faculty of Pharmaceutical Sciences, Nagoya City University.
Matsunaga T; Department of Clinical Pharmacy, Graduate School and Faculty of Pharmaceutical Sciences, Nagoya City University.
Ito K; Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University.
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Źródło :
The Journal of toxicological sciences [J Toxicol Sci] 2022; Vol. 47 (1), pp. 13-18.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatocytes*
Oxidative Phosphorylation*
Animals ; Cells, Cultured ; Glycolysis ; Liver/metabolism ; Mice ; Oxygen Consumption ; Perfusion
Czasopismo naukowe
Tytuł :
Interleukin-9 attenuates inflammatory response and hepatocyte apoptosis in alcoholic liver injury.
Autorzy :
Meng H; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.
Niu R; Department of pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
You H; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.
Wang L; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.
Feng R; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.
Huang C; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China. Electronic address: .
Li J; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, China; The Key laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei 230032, China; Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2022 Jan 01; Vol. 288, pp. 120180. Date of Electronic Publication: 2021 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Chemical and Drug Induced Liver Injury/*prevention & control
Ethanol/*toxicity
Hepatocytes/*pathology
Interleukin-9/*metabolism
Macrophages/*immunology
STAT3 Transcription Factor/*metabolism
Animals ; Central Nervous System Depressants/toxicity ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Hepatocytes/immunology ; Hepatocytes/metabolism ; Interleukin-9/genetics ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Mice ; Mice, Inbred C57BL ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
RNR-R2 Upregulation by a Short Non-Coding Viral Transcript.
Autorzy :
Broennimann K; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Ricardo-Lax I; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.; Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065, USA.
Adler J; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Michailidis E; Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065, USA.
de Jong YP; Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY 10065, USA.; Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NY 10065, USA.
Reuven N; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Shaul Y; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
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Źródło :
Biomolecules [Biomolecules] 2021 Dec 03; Vol. 11 (12). Date of Electronic Publication: 2021 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Hepatitis B virus/*physiology
Hepatocytes/*cytology
RNA, Untranslated/*genetics
Ribonucleoside Diphosphate Reductase/*genetics
Cells, Cultured ; HEK293 Cells ; Hep G2 Cells ; Hepatocytes/metabolism ; Hepatocytes/virology ; Humans ; Open Reading Frames ; Primary Cell Culture ; RNA, Viral/genetics ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Viral Regulatory and Accessory Proteins/genetics ; Viral Regulatory and Accessory Proteins/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3.
Autorzy :
Geng Y; Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
Wang Y; Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
Sun R; Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
Kang X; Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
Zhao H; Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
Zhu M; Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
Sun Y; Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
Hu Y; Department of Pharmacy, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.
Wang Z; Department of Pharmacology, Dalian Medical University, Dalian 116044, China.
Tian X; Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.
Zhao Y; Department of Pharmacology, Dalian Medical University, Dalian 116044, China. Electronic address: .
Yao J; Department of Pharmacology, Dalian Medical University, Dalian 116044, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Dec 01; Vol. 432, pp. 115758. Date of Electronic Publication: 2021 Oct 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Abietanes/*pharmacology
Apoptosis/*drug effects
Enzyme Activators/*pharmacology
Hepatocytes/*drug effects
Liver/*drug effects
Mitochondria, Liver/*drug effects
Non-alcoholic Fatty Liver Disease/*prevention & control
Peroxiredoxin III/*metabolism
Animals ; Antioxidants/pharmacology ; Cell Line ; Diet, High-Fat ; Disease Models, Animal ; Enzyme Activation ; Hepatocytes/enzymology ; Hepatocytes/pathology ; Liver/enzymology ; Liver/pathology ; Male ; Mice, Inbred C57BL ; Mitochondria, Liver/enzymology ; Mitochondria, Liver/pathology ; Mitochondrial Dynamics/drug effects ; Non-alcoholic Fatty Liver Disease/enzymology ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/pathology ; Oxidative Stress/drug effects ; Palmitic Acid/toxicity ; Peroxiredoxin III/genetics
Czasopismo naukowe
Tytuł :
Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect.
Autorzy :
Pászti-Gere E; Department of Pharmacology and Toxicology, University of Veterinary Medicine, Budapest, Hungary.
Pomothy J; Department of Pharmacology and Toxicology, University of Veterinary Medicine, Budapest, Hungary.
Jerzsele Á; Department of Pharmacology and Toxicology, University of Veterinary Medicine, Budapest, Hungary.
Pilgram O; Faculty of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marburg, Germany.
Steinmetzer T; Faculty of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marburg, Germany.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 659-668.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Epithelial Cells/*drug effects
Hepatocytes/*drug effects
Phenylalanine/*pharmacology
Protease Inhibitors/*pharmacology
Serine Endopeptidases/*metabolism
Cell Line ; Cell Survival/drug effects ; Epithelial Cells/cytology ; Epithelial Cells/enzymology ; Gene Expression Regulation/drug effects ; Hepatocytes/cytology ; Hepatocytes/enzymology ; Humans ; Hydrogen Peroxide/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Interleukin-8/genetics ; Interleukin-8/metabolism ; Intestinal Mucosa/cytology ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/enzymology ; Occludin/genetics ; Occludin/metabolism ; Oxidation-Reduction/drug effects ; Phenylalanine/analogs & derivatives ; Primary Cell Culture ; Serine Endopeptidases/genetics
Czasopismo naukowe
Tytuł :
Hepatitis B virus nucleocapsid uncoating: biological consequences and regulation by cellular nucleases.
Autorzy :
Hu J; Department of Experimental Medicine, Baruch S. Blumberg Institute, Doylestown, PA, USA.; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Tang L; Department of Experimental Medicine, Baruch S. Blumberg Institute, Doylestown, PA, USA.; Microbiology and Immunology Graduate Program, Drexel University College of Medicine, Philadelphia, PA, USA.
Cheng J; Department of Experimental Medicine, Baruch S. Blumberg Institute, Doylestown, PA, USA.
Zhou T; Department of Experimental Medicine, Baruch S. Blumberg Institute, Doylestown, PA, USA.
Li Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Chang J; Department of Experimental Medicine, Baruch S. Blumberg Institute, Doylestown, PA, USA.
Zhao Q; Department of Experimental Medicine, Baruch S. Blumberg Institute, Doylestown, PA, USA.
Guo JT; Department of Experimental Medicine, Baruch S. Blumberg Institute, Doylestown, PA, USA.
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Źródło :
Emerging microbes & infections [Emerg Microbes Infect] 2021 Dec; Vol. 10 (1), pp. 852-864.
Typ publikacji :
Journal Article
MeSH Terms :
DNA, Circular/*genetics
Exodeoxyribonucleases/*metabolism
Hepatitis B virus/*genetics
Hepatocytes/*virology
Nucleocapsid/*genetics
Phosphoproteins/*metabolism
Cell Line ; Cytoplasm/genetics ; DNA, Circular/immunology ; DNA, Viral/genetics ; DNA, Viral/immunology ; Exodeoxyribonucleases/genetics ; Hep G2 Cells ; Hepatitis B virus/immunology ; Hepatocytes/cytology ; Hepatocytes/immunology ; Humans ; Immunity, Innate ; Mutation ; Nucleocapsid/immunology ; Nucleotidyltransferases/metabolism ; Phosphoproteins/genetics
Czasopismo naukowe
Tytuł :
Suppression of apoptotic signaling in rat hepatocytes by non-dioxin-like polychlorinated biphenyls depends on the receptors CAR and PXR.
Autorzy :
Gährs M; Food Chemistry and Toxicology, University of Kaiserslautern, Kaiserslautern, Germany.
Schrenk D; Food Chemistry and Toxicology, University of Kaiserslautern, Kaiserslautern, Germany. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2021 Dec; Vol. 464, pp. 153023. Date of Electronic Publication: 2021 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
Constitutive Androstane Receptor/*metabolism
Hepatocytes/*drug effects
Polychlorinated Biphenyls/*toxicity
Pregnane X Receptor/*metabolism
Animals ; Apoptosis/drug effects ; Apoptosis/radiation effects ; Constitutive Androstane Receptor/genetics ; Dexamethasone/pharmacology ; Gene Knockout Techniques ; Hepatocytes/pathology ; Male ; Phenobarbital/pharmacology ; Pregnane X Receptor/genetics ; Rats ; Rats, Wistar ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Optimized 3D Culture of Hepatic Cells for Liver Organoid Metabolic Assays.
Autorzy :
Gamboa CM; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ 08901, USA.
Wang Y; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
Xu H; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
Kalemba K; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
Wondisford FE; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ 08901, USA.; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
Sabaawy HE; Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ 08901, USA.; Department of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.; Department of Pathology and Laboratory Medicine, RBHS-Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.
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Źródło :
Cells [Cells] 2021 Nov 24; Vol. 10 (12). Date of Electronic Publication: 2021 Nov 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Culture Techniques*
Biological Assay/*methods
Hepatocytes/*metabolism
Liver/*metabolism
Organoids/*metabolism
Adult ; Albumins/metabolism ; Biomarkers/metabolism ; Cell Proliferation/drug effects ; Cell Shape/drug effects ; Culture Media/pharmacology ; Freezing ; Glucose-6-Phosphatase/metabolism ; Hep G2 Cells ; Hepatocyte Nuclear Factor 4/metabolism ; Hepatocytes/cytology ; Hepatocytes/drug effects ; Humans ; Organoids/drug effects ; Phosphoenolpyruvate Carboxykinase (ATP)/metabolism
Czasopismo naukowe
Tytuł :
Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human Hepatocytes.
Autorzy :
Nicolay W; TWINCORE-Centre for Experimental and Clinical Infection Research, Institute for Experimental Virology, 30625 Hannover, Germany.
Moeller R; TWINCORE-Centre for Experimental and Clinical Infection Research, Institute for Experimental Virology, 30625 Hannover, Germany.; Center for Emerging Infections and Zoonoses (RIZ), Institute of Biochemistry & Research, University of Veterinary Medicine Hannover, 30625 Hannover, Germany.
Kahl S; TWINCORE-Centre for Experimental and Clinical Infection Research, Institute for Experimental Virology, 30625 Hannover, Germany.
Vondran FWR; Department of General, Visceral and Transplant Surgery, Hannover Medical School, 30625 Hannover, Germany.; German Centre for Infection Research (DZIF), 30100 Braunschweig, Germany.
Pietschmann T; TWINCORE-Centre for Experimental and Clinical Infection Research, Institute for Experimental Virology, 30625 Hannover, Germany.
Kunz S; Institute of Microbiology, Lausanne University Hospital, CH-1011 Lausanne, Switzerland.
Gerold G; TWINCORE-Centre for Experimental and Clinical Infection Research, Institute for Experimental Virology, 30625 Hannover, Germany.; Center for Emerging Infections and Zoonoses (RIZ), Institute of Biochemistry & Research, University of Veterinary Medicine Hannover, 30625 Hannover, Germany.; Department of Clinical Microbiology, Virology, Umeå University, SE-90185 Umeå, Sweden.; Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, SE-90185 Umeå, Sweden.
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Źródło :
Cells [Cells] 2021 Nov 04; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 04.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Hepatocytes/*immunology
RNA/*immunology
Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cells, Cultured ; DEAD Box Protein 58/immunology ; Hepatocytes/virology ; Humans ; Interferons/immunology ; Liver/cytology ; Liver/immunology ; Liver/virology ; Liver Neoplasms/pathology ; RNA Viruses/physiology ; Receptors, Immunologic/immunology ; Signal Transduction/immunology ; Toll-Like Receptor 3/immunology ; Viral Load
Czasopismo naukowe
Tytuł :
GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis.
Autorzy :
Ding K; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Li X; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Ren X; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), School of Life Sciences, Northeast Normal University, Changchun, China.; Shenyang University of Chemical Technology, Shenyang, China.
Ding N; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Tao L; 305 Hospital of People's Liberation Army, Beijing, China.
Dong X; Key Laboratory of Molecular Epigenetics of the Ministry of Education (MOE), School of Life Sciences, Northeast Normal University, Changchun, China.
Chen Z; HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2022 Jan; Vol. 36 (1), pp. e22119.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Signal Transduction*
GTP-Binding Proteins/*metabolism
Hepatocytes/*metabolism
Liver/*injuries
Liver/*metabolism
Animals ; GTP-Binding Proteins/genetics ; HEK293 Cells ; Hepatocytes/pathology ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Liver/pathology ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake.
Autorzy :
Jalili-Nik M; Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahboobnia K; Department of Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Guest PC; Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Majeed M; Sabinsa Corporation, East Windsor, NJ, USA.
Al-Rasadi K; Medical Research Centre, Sultan Qaboos University, Muscat, Oman.
Jamialahmadi T; Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran.; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Sahebkar A; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. .; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. .; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. .; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2343, pp. 395-400.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatocytes*
Liver*
Atherosclerosis ; Cholesterol, LDL ; Curcumin/pharmacology ; Humans
Czasopismo naukowe
Tytuł :
Rapid detection and structural characterization of methysticin metabolites generated from rat and human liver microsomes and hepatocytes using ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry.
Autorzy :
Tuerxuntayi A; Xinjiang Key Laboratory of Special Species Conservation and Regulatory Biology, Key Laboratory of Plant Stress Biology in Arid Land, College of Life Science, Xinjiang Normal University, Urumqi, China.
Tusun A; Xinjiang Key Laboratory of Special Species Conservation and Regulatory Biology, Key Laboratory of Plant Stress Biology in Arid Land, College of Life Science, Xinjiang Normal University, Urumqi, China.
Tajiguli A; Xinjiang Key Laboratory of Special Species Conservation and Regulatory Biology, Key Laboratory of Plant Stress Biology in Arid Land, College of Life Science, Xinjiang Normal University, Urumqi, China.
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Źródło :
Rapid communications in mass spectrometry : RCM [Rapid Commun Mass Spectrom] 2021 Dec 30; Vol. 35 (24), pp. e9208.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatocytes/*chemistry
Microsomes, Liver/*chemistry
Pyrans/*chemistry
Pyrans/*metabolism
Animals ; Chromatography, High Pressure Liquid ; Hepatocytes/metabolism ; Humans ; Hydroxylation ; Mass Spectrometry ; Metabolome ; Microsomes, Liver/metabolism ; Molecular Structure ; Rats
Czasopismo naukowe
Tytuł :
Liver Regeneration and Cell Transplantation for End-Stage Liver Disease.
Autorzy :
Li Y; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Lu L; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Cai X; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
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Źródło :
Biomolecules [Biomolecules] 2021 Dec 20; Vol. 11 (12). Date of Electronic Publication: 2021 Dec 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
End Stage Liver Disease/*therapy
Hepatocytes/*transplantation
Tissue Engineering/*methods
Hepatocytes/cytology ; Humans ; Liver Regeneration ; Regenerative Medicine ; Stem Cell Transplantation ; Stem Cells/cytology
Czasopismo naukowe
Tytuł :
Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury.
Autorzy :
Schofield CA; Functional Genomics, Medicinal Science and Technology, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
Walker TM; Oncology Cell Therapy, Oncology Therapy Area, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
Taylor MA; Drug Metabolism and Pharmacokinetics, In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Ware, Herts SG12 0DP, United Kingdom.
Patel M; Screening, Profiling and Mechanistic Biology, Medicinal Science and Technology, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
Vlachou DF; Molecular Design U.K., Medicinal Science and Technology, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
Macina JM; Screening, Profiling and Mechanistic Biology, Medicinal Science and Technology, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
Vidgeon-Hart MP; Non Clinical Safety, In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Ware, Herts SG12 0DP, United Kingdom.
Williams A; Pathology U.K., In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Ware, Herts SG12 0DP, United Kingdom.
McGill PJ; Bioimaging U.K., In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Ware, Herts SG12 0DP, United Kingdom.
Newman CF; Bioimaging U.K., In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
Sakatis MZ; Non Clinical Safety, In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Ware, Herts SG12 0DP, United Kingdom.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2021 Dec 20; Vol. 34 (12), pp. 2485-2499. Date of Electronic Publication: 2021 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Chemical and Drug Induced Liver Injury/*pathology
Hepatocytes/*drug effects
Pharmaceutical Preparations/*chemistry
Spheroids, Cellular/*drug effects
Animals ; Cell Survival/drug effects ; Drug Evaluation, Preclinical ; Hep G2 Cells ; Hepatocytes/pathology ; Humans ; Male ; Rats ; Rats, Wistar ; Spheroids, Cellular/pathology
Czasopismo naukowe
Tytuł :
Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine.
Autorzy :
Xue Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Ren X; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Zhu Z; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; Beijing Institute of Big Data Research, Beijing 100871, China.
Lei P; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Liu M; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wan M; Waters Technology (Shanghai), Co., Ltd, Shanghai 201203, China.
Zhong D; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Huang H; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Diao X; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Dec 15; Vol. 287, pp. 120125. Date of Electronic Publication: 2021 Nov 08.
Typ publikacji :
Journal Article
MeSH Terms :
Acetylcysteine/*metabolism
Benzofurans/*metabolism
Benzofurans/*toxicity
Glutathione/*metabolism
Hepatocytes/*metabolism
Animals ; Binding Sites/physiology ; Cells, Cultured ; Cytochrome P-450 CYP3A Inducers/metabolism ; Cytochrome P-450 CYP3A Inducers/toxicity ; Dose-Response Relationship, Drug ; Hepatocytes/drug effects ; Humans ; Protein Structure, Tertiary ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes.
Autorzy :
Li Z; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA.
Li L; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA.
Heyward S; BioIVT, 1450 S Rolling Road, Halethorpe, MD 21227, USA.
Men S; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA.
Xu M; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Sueyoshi T; Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Wang H; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA.
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Źródło :
Cells [Cells] 2021 Dec 01; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Constitutive Androstane Receptor/*metabolism
Hepatocytes/*metabolism
Phenobarbital/*pharmacology
Pregnane X Receptor/*metabolism
Symporters/*genetics
Base Sequence ; Cells, Cultured ; Gene Expression Regulation/drug effects ; Hepatocytes/drug effects ; Humans ; Introns/genetics ; Metformin/pharmacology ; Models, Biological ; Pregnane X Receptor/antagonists & inhibitors ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Response Elements/genetics ; Symporters/metabolism
Czasopismo naukowe
Tytuł :
Immunohistochemical detection of hepatocyte nuclear factor-4α in vertebrates.
Autorzy :
Jiang S; Niigata College of Medical Technology, Niigata, Japan.; Division of Molecular and Diagnostic Pathology, Graduate Scholl of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Tanaka T; Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.
Yagami R; Division of International Health (Public Health) Graduate Scholl of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Hasegawa G; Division of Pathology, Niigata University Medical and Dental Hospital, Niigata, Japan.
Umezu H; Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.
Fujiyoshi Y; Department of Pathology and Molecular Diagnostics, Nagoya City Graduate School of Medical Sciences, Nagoya, Japan.
Kodama T; Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.
Naito M; Department of Pathology, Niigata Medical Center, Nishi-ku, Niigata, Japan.
Ajioka Y; Division of Molecular and Diagnostic Pathology, Graduate Scholl of Medical and Dental Sciences, Niigata University, Niigata, Japan.
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Źródło :
Microscopy research and technique [Microsc Res Tech] 2021 Dec; Vol. 84 (12), pp. 2906-2914. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatocyte Nuclear Factor 4*/genetics
Hepatocyte Nuclear Factor 4*/metabolism
Hepatocytes*
Animals ; Immunohistochemistry ; Mice ; Promoter Regions, Genetic ; Rats ; Vertebrates/metabolism
Czasopismo naukowe
Tytuł :
The Pannexin 1/Purinergic Receptor P2X4 Pathway Controls the Secretion of MicroRNA-Containing Exosomes by HCV-Infected Hepatocytes.
Autorzy :
Kim OK; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA.; Division of Food and Nutrition, Chonnam National University, Gwangju, South Korea.
Nam DE; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA.
Hahn YS; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA.
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Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2021 Dec; Vol. 74 (6), pp. 3409-3426. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Connexins/*metabolism
Hepatitis C, Chronic/*genetics
Hepatocytes/*virology
MicroRNAs/*metabolism
Nerve Tissue Proteins/*metabolism
Receptors, Purinergic P2X4/*metabolism
Blotting, Western ; Cell Line ; Exosomes/metabolism ; Flow Cytometry ; Hepatocytes/metabolism ; Humans ; Microscopy, Fluorescence ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Modeling PNPLA3-Associated NAFLD Using Human-Induced Pluripotent Stem Cells.
Autorzy :
Tilson SG; Wellcome Sanger Institute, Hinxton, United Kingdom.; Wellcome Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Morell CM; Wellcome Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Lenaerts AS; Wellcome Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Park SB; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Hu Z; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Jenkins B; Wellcome Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Koulman A; Wellcome Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Liang TJ; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Vallier L; Wellcome Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
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Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2021 Dec; Vol. 74 (6), pp. 2998-3017. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hepatocytes/*pathology
Lipase/*genetics
Membrane Proteins/*genetics
Non-alcoholic Fatty Liver Disease/*genetics
CRISPR-Cas Systems/genetics ; Cell Differentiation ; Cell Line ; Ethanol/toxicity ; Gene Knockout Techniques ; Genetic Predisposition to Disease ; Hepatocytes/drug effects ; Humans ; Induced Pluripotent Stem Cells ; Lipid Metabolism/genetics ; Loss of Function Mutation ; Methotrexate/toxicity ; Non-alcoholic Fatty Liver Disease/pathology ; Polymorphism, Single Nucleotide ; Toxicity Tests, Acute
Czasopismo naukowe
Tytuł :
Programmed Instability of Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides.
Autorzy :
Terada C; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Wada F; Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Uchida M; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Yasutomi Y; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Oh K; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Kawamoto S; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Kayaba Y; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Yamayoshi A; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Harada-Shiba M; Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Obika S; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Yamamoto T; Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
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Źródło :
Nucleic acid therapeutics [Nucleic Acid Ther] 2021 Dec; Vol. 31 (6), pp. 404-416. Date of Electronic Publication: 2021 Aug 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hepatocytes*
Oligonucleotides*/genetics
Acetylgalactosamine ; Asialoglycoprotein Receptor/genetics ; Ligands
Czasopismo naukowe

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