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Tytuł:
High levels of Myc expression are required for the robust proliferation of hepatocytes, but not for the sustained weak proliferation.
Autorzy:
Goto M; Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Ooshio T; Division of Biomedical Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan.
Yamamoto M; Department of Morphological and Physiological Sciences, Graduate School of Health Science, Kumamoto University, Kumamoto 862-0976, Japan.
Tanaka H; Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Fujii Y; Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Meng L; Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Kamikokura Y; Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Okada Y; Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.
Nishikawa Y; Division of Tumor Pathology, Department of Pathology, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan. Electronic address: .
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Źródło:
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2023 Apr; Vol. 1869 (4), pp. 166644. Date of Electronic Publication: 2023 Jan 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Proliferation*/genetics
Hepatocytes*/metabolism
Proto-Oncogene Proteins c-myc*/genetics
Proto-Oncogene Proteins c-myc*/metabolism
Animals ; Mice ; Hepatectomy ; Liver/metabolism ; Liver Regeneration/genetics
Czasopismo naukowe
Szczegóły
Tytuł:
2D and 3D liver models.
Autorzy:
Saxton SH; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98105, USA.
Stevens KR; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98105, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98105, USA; Brotman Baty Institute, University of Washington, Seattle, WA 98105, USA. Electronic address: .
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Źródło:
Journal of hepatology [J Hepatol] 2023 Apr; Vol. 78 (4), pp. 873-875. Date of Electronic Publication: 2022 Aug 26.
Typ publikacji:
Journal Article
MeSH Terms:
Liver*
Hepatocytes*
Czasopismo naukowe
Szczegóły
Tytuł:
Differential effects of oleate on vascular endothelial and liver sinusoidal endothelial cells reveal its toxic features in vitro.
Autorzy:
Geng Y; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands. Electronic address: .
Arroyave-Ospina JC; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Buist-Homan M; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Plantinga J; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Olinga P; Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
Reijngoud DJ; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Van Vilsteren FGI; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Blokzijl H; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Kamps JAAM; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Moshage H; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: .
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Źródło:
The Journal of nutritional biochemistry [J Nutr Biochem] 2023 Apr; Vol. 114, pp. 109255. Date of Electronic Publication: 2023 Jan 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Oleic Acid*/pharmacology
Oleic Acid*/metabolism
Hepatocytes*/metabolism
Rats ; Animals ; Humans ; Fatty Acids/metabolism ; Palmitic Acid/toxicity ; Palmitic Acid/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Liver/metabolism ; Palmitates/toxicity ; Palmitates/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Short-term semaglutide treatment improves FGF21 responsiveness in primary hepatocytes isolated from high fat diet challenged mice.
Autorzy:
Feng JN; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.; Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Shao W; Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Jin T; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.; Division of Advanced Diagnostics, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
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Źródło:
Physiological reports [Physiol Rep] 2023 Mar; Vol. 11 (5), pp. e15620.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diet, High-Fat*
Fibroblast Growth Factors*/metabolism
Hepatocytes*/metabolism
Glucagon-Like Peptides*/pharmacology
Animals ; Mice ; Liver/metabolism ; Mice, Inbred C57BL ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A hepatoprotective role of peritumoral non-parenchymal cells in early liver tumorigenesis.
Autorzy:
Tian C; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li L; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Fan L; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Brown A; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Norris EJ; STEMCELL Technologies, Vancouver, BC V6A 1B6, Canada.
Morrison M; Department of Surgery and Cancer Center, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Glazer ES; Department of Surgery and Cancer Center, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Zhu L; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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Źródło:
Disease models & mechanisms [Dis Model Mech] 2023 Mar 01; Vol. 16 (3). Date of Electronic Publication: 2023 Mar 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatocytes*/metabolism
Liver*/metabolism
Mice ; Animals ; Hepatic Stellate Cells/metabolism ; Coculture Techniques ; Carcinogenesis/pathology
Czasopismo naukowe
Szczegóły
Tytuł:
Highly efficient fabrication of functional hepatocyte spheroids by a magnetic system for the rescue of acute liver failure.
Autorzy:
Zhang J; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China; Guangdong Provincial Key Laboratory of Liver Disease, Guangzhou, Guangdong, 510630, China.
Xu Y; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China; Guangdong Provincial Key Laboratory of Liver Disease, Guangzhou, Guangdong, 510630, China.
Zhuo C; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China; Guangdong Provincial Key Laboratory of Liver Disease, Guangzhou, Guangdong, 510630, China.
Shi R; Department of Oncology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China.
Wang H; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
Hu Z; School of Biology and Engineering, Guizhou Medical University, Guiyang, 550025, China.
Chan HF; Institute for Tissue Engineering and Regenerative Medicine, School of Biomedical Science, The Chinese University of Hong Kong, Hong Kong, 999077, China.
Kim HW; Institute of Tissue Regeneration Engineering (ITREN), Department of Nanobiomedical Science and BK21 Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 330-714, South Korea.
Tao Y; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China; Guangdong Provincial Key Laboratory of Liver Disease, Guangzhou, Guangdong, 510630, China. Electronic address: .
Li M; Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China; Guangdong Provincial Key Laboratory of Liver Disease, Guangzhou, Guangdong, 510630, China. Electronic address: .
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Źródło:
Biomaterials [Biomaterials] 2023 Mar; Vol. 294, pp. 122014. Date of Electronic Publication: 2023 Jan 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatocytes*
Liver Failure, Acute*/therapy
Mice ; Animals ; Spheroids, Cellular ; Physical Phenomena ; Magnetic Phenomena
Czasopismo naukowe
Szczegóły
Tytuł:
Altered hallmarks of DNA double-strand breaks, oxidative DNA damage and cytogenotoxicity by piperlongumine in hippocampus and hepatocytes of rats intoxicated with cyclophosphamide.
Autorzy:
Yadav V; Neurobehavioral Pharmacology Laboratory, Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
Krishnan A; Department of Molecular Medicine, School of Interdisciplinary Science and Technology, Jamia Hamdard, New Delhi 110062, India.
Vohora D; Neurobehavioral Pharmacology Laboratory, Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address: .
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Źródło:
Life sciences [Life Sci] 2023 Mar 01; Vol. 316, pp. 121391. Date of Electronic Publication: 2023 Jan 16.
Typ publikacji:
Journal Article
MeSH Terms:
Oxidative Stress*
Hepatocytes*
Animals ; Rats ; Rats, Wistar ; Cyclophosphamide/toxicity ; DNA Damage ; DNA ; Hippocampus
Czasopismo naukowe
Szczegóły
Tytuł:
Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury.
Autorzy:
Njeka Wojnarova L; Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
Kutinova Canova N; Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
Arora M; Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
Farghali H; Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
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Źródło:
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia [Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub] 2023 Mar; Vol. 167 (1), pp. 50-60. Date of Electronic Publication: 2022 Apr 12.
Typ publikacji:
Journal Article
MeSH Terms:
AMP-Activated Protein Kinases*/chemistry
AMP-Activated Protein Kinases*/metabolism
AMP-Activated Protein Kinases*/pharmacology
Chemical and Drug Induced Liver Injury*/etiology
Chemical and Drug Induced Liver Injury*/genetics
Chemical and Drug Induced Liver Injury*/metabolism
Chemical and Drug Induced Liver Injury*/pathology
Hepatocytes*/metabolism
Sirtuin 1*/metabolism
Sirtuin 1*/pharmacology
Animals ; Rats ; Acetaminophen/toxicity ; Cyclopentanes/pharmacology
Czasopismo naukowe
Szczegóły
Tytuł:
Robust protein-based engineering of hepatocyte-like cells from human mesenchymal stem cells.
Autorzy:
Takashina T; Department of Intractable Diseases, National Center for Global Health and Medicine, Tokyo, Japan.
Matsunaga A; Department of Intractable Diseases, National Center for Global Health and Medicine, Tokyo, Japan.
Shimizu Y; Department of Laboratory Animal Medicine, National Center for Global Health and Medicine, Tokyo, Japan.; Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Sakuma T; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Okamura T; Department of Laboratory Animal Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
Matsuoka K; Deafness Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Yamamoto T; Division of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
Ishizaka Y; Department of Intractable Diseases, National Center for Global Health and Medicine, Tokyo, Japan.
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Źródło:
Hepatology communications [Hepatol Commun] 2023 Feb 27; Vol. 7 (3), pp. e0051. Date of Electronic Publication: 2023 Feb 27 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatocytes*
Liver Failure*
Humans ; Animals ; Mice ; Immunologic Factors ; Cell Differentiation/genetics ; Bile Ducts
Czasopismo naukowe
Szczegóły
Tytuł:
Targeted delivery of oligonucleotides using multivalent protein-carbohydrate interactions.
Autorzy:
Kumar V; Department of Chemistry, Akal University, Talwandi Sabo, Bathinda, Punjab, India. .; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. .
Turnbull WB; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. .
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Źródło:
Chemical Society reviews [Chem Soc Rev] 2023 Feb 20; Vol. 52 (4), pp. 1273-1287. Date of Electronic Publication: 2023 Feb 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Oligonucleotides*/metabolism
Hepatocytes*/metabolism
Asialoglycoprotein Receptor/genetics ; Asialoglycoprotein Receptor/metabolism ; Ligands ; Carbohydrates
Czasopismo naukowe
Szczegóły
Tytuł:
Pre-Diabetes-Linked miRNA miR-193b-3p Targets PPARGC1A, Disrupts Metabolic Gene Expression Profile and Increases Lipid Accumulation in Hepatocytes: Relevance for MAFLD.
Autorzy:
Mollet IG; iNOVA4Health, NOVA Medical School (NMS), Faculdade de Ciências Médicas (FCM), Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal.; UCIBIO-Requimte, Faculdade de Ciências e Tecnologia (FCT), Universidade NOVA de Lisboa, 2825-149 Caparica, Portugal.
Macedo MP; iNOVA4Health, NOVA Medical School (NMS), Faculdade de Ciências Médicas (FCM), Universidade NOVA de Lisboa, 1150-082 Lisboa, Portugal.; Associação Protectora dos Diabéticos de Portugal, Education Research Center (APDP-ERC), 1250-203 Lisbon, Portugal.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 15; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*/metabolism
Liver Diseases*/metabolism
MicroRNAs*/genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha*/metabolism
Prediabetic State*/metabolism
Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Adverse Toxic Effects of Tyrosine Kinase Inhibitors on Non-Target Zebrafish Liver (ZFL) Cells.
Autorzy:
Kološa K; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 111, 1000 Ljubljana, Slovenia.
Žegura B; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 111, 1000 Ljubljana, Slovenia.; Jozef Stefan International Postgraduate School, 1000 Ljubljana, Slovenia.
Štampar M; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 111, 1000 Ljubljana, Slovenia.
Filipič M; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 111, 1000 Ljubljana, Slovenia.; Jozef Stefan International Postgraduate School, 1000 Ljubljana, Slovenia.
Novak M; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 111, 1000 Ljubljana, Slovenia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 15; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/toxicity
Hepatocytes*/drug effects
Tyrosine Protein Kinase Inhibitors*/toxicity
Animals ; Humans ; Liver ; Pyrimidines/toxicity ; Sorafenib/toxicity ; Zebrafish
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes.
Autorzy:
Higgins CB; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.
Adams JA; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.
Ward MH; Department of Chemistry, Washington University in St Louis, St Louis, Missouri, USA.
Greenberg ZJ; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.
Milewska M; Biotechnology Center, Silesian University of Technology, Gliwice, Poland; Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Gliwice, Poland.
Sun J; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.
Zhang Y; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.
Chiquetto Paracatu L; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.
Dong Q; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.
Ballentine S; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA.
Li W; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri, USA.
Wandzik I; Biotechnology Center, Silesian University of Technology, Gliwice, Poland; Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Gliwice, Poland.
Schuettpelz LG; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA; Siteman Cancer Center, Washington University, St. Louis, Missouri, USA.
DeBosch BJ; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA; Department of Cell Biology & Physiology, Washington University School of Medicine, St Louis, Missouri, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Feb; Vol. 299 (2), pp. 102835. Date of Electronic Publication: 2022 Dec 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatocytes*/metabolism
Non-alcoholic Fatty Liver Disease*/metabolism
Tetraspanin 25*/metabolism
Animals ; Mice ; Diet, High-Fat ; Inflammation/genetics ; Inflammation/metabolism ; Liver/metabolism ; Mice, Inbred C57BL ; Obesity/metabolism ; Tetraspanins/genetics ; Tetraspanins/metabolism ; Trehalose/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling.
Autorzy:
Blackford SJI; Department of Metabolism, Digestion and Reproduction, Imperial College London, UK; Centre for Craniofacial & Regenerative Biology, King's College London, UK; Centre for Gene Therapy & Regenerative Medicine, King's College London, UK; NIHR Imperial BRC iPSC and Organoid Core Facility, Imperial College London, UK. Electronic address: .
Yu TTL; Centre for Craniofacial & Regenerative Biology, King's College London, UK.
Norman MDA; Centre for Craniofacial & Regenerative Biology, King's College London, UK.
Syanda AM; Department of Metabolism, Digestion and Reproduction, Imperial College London, UK; NIHR Imperial BRC iPSC and Organoid Core Facility, Imperial College London, UK.
Manolakakis M; MRC London Institute of Medical Sciences, UK; Institute of Clinical Sciences, Imperial College London, UK.
Lachowski D; Cellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, UK.
Yan Z; Centre for Craniofacial & Regenerative Biology, King's College London, UK.
Guo Y; Centre for Craniofacial & Regenerative Biology, King's College London, UK.
Garitta E; Department of Metabolism, Digestion and Reproduction, Imperial College London, UK; NIHR Imperial BRC iPSC and Organoid Core Facility, Imperial College London, UK.
Riccio F; Centre for Gene Therapy & Regenerative Medicine, King's College London, UK.
Jowett GM; Centre for Craniofacial & Regenerative Biology, King's College London, UK; Centre for Gene Therapy & Regenerative Medicine, King's College London, UK.
Ng SS; Department of Metabolism, Digestion and Reproduction, Imperial College London, UK; NIHR Imperial BRC iPSC and Organoid Core Facility, Imperial College London, UK.
Vernia S; MRC London Institute of Medical Sciences, UK; Institute of Clinical Sciences, Imperial College London, UK.
Del Río Hernández AE; Cellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, UK.
Gentleman E; Centre for Craniofacial & Regenerative Biology, King's College London, UK. Electronic address: .
Rashid ST; Department of Metabolism, Digestion and Reproduction, Imperial College London, UK; NIHR Imperial BRC iPSC and Organoid Core Facility, Imperial College London, UK. Electronic address: .
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Źródło:
Biomaterials [Biomaterials] 2023 Feb; Vol. 293, pp. 121982. Date of Electronic Publication: 2022 Dec 22.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*
Oligopeptides*/pharmacology
Oligopeptides*/metabolism
Humans ; Colforsin/metabolism ; Colforsin/pharmacology ; Cell Differentiation ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P-450 Enzyme System/pharmacology ; Hydrogels/chemistry
Czasopismo naukowe
Szczegóły
Tytuł:
Innate antiviral immunity and immunometabolism in hepatocytes.
Autorzy:
Sularea VM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Sugrue JA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
O'Farrelly C; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; School of Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address: .
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Źródło:
Current opinion in immunology [Curr Opin Immunol] 2023 Feb; Vol. 80, pp. 102267. Date of Electronic Publication: 2022 Nov 30.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiviral Agents*/metabolism
Hepatocytes*
Humans ; Immunity, Innate ; Liver ; Inflammation/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
PROM1-mediated cell signal transduction in cancer stem cells and hepatocytes.
Autorzy:
Bahn MS; Division of Life Sciences, Korea University, Seoul 02841, Korea.
Ko YG; Division of Life Sciences, Korea University, Seoul 02841, Korea.
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Źródło:
BMB reports [BMB Rep] 2023 Feb; Vol. 56 (2), pp. 65-70.
Typ publikacji:
News; Review
MeSH Terms:
AC133 Antigen*/metabolism
Hepatocytes*/metabolism
Neoplastic Stem Cells*/metabolism
Signal Transduction*
Animals ; Humans ; Mice ; Neoplasms/metabolism
Recenzja
Szczegóły
Tytuł:
Hyperphosphorylation of EGFR/ERK signaling facilitates long-term arsenite-induced hepatocytes epithelial-mesenchymal transition and liver fibrosis in sprague-dawley rats.
Autorzy:
Wang D; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China. Electronic address: .
Xu H; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Fan L; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Ruan W; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China; Tongren Center for Disease Control and Prevention, Tongren 554300, Guizhou, China.
Song Q; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Diao H; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
He R; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
Jin Y; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang 550025, Guizhou, China.
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Źródło:
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2023 Jan 01; Vol. 249, pp. 114386. Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:
Journal Article
MeSH Terms:
Arsenic*/toxicity
Arsenites*/toxicity
Epithelial-Mesenchymal Transition*/drug effects
Hepatocytes*/drug effects
Hepatocytes*/pathology
Liver Cirrhosis*/chemically induced
Animals ; Rats ; ErbB Receptors ; Rats, Sprague-Dawley
Czasopismo naukowe
Szczegóły
Tytuł:
The PTEX Pore Component EXP2 Is Important for Intrahepatic Development during the Plasmodium Liver Stage.
Autorzy:
Hussain T; Department of Biomedical Sciences, Iowa State University, Ames, Iowa, USA.
Linera-Gonzalez J; Department of Biomedical Sciences, Iowa State University, Ames, Iowa, USA.
Beck JM; Department of Biomedical Sciences, Iowa State University, Ames, Iowa, USA.; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, Iowa, USA.
Fierro MA; Department of Biomedical Sciences, Iowa State University, Ames, Iowa, USA.
Mair GR; Department of Biomedical Sciences, Iowa State University, Ames, Iowa, USA.
Smith RC; Department of Plant Pathology, Entomology and Microbiology, Iowa State University, Ames, Iowa, USA.
Beck JR; Department of Biomedical Sciences, Iowa State University, Ames, Iowa, USA.; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, Iowa, USA.
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Źródło:
MBio [mBio] 2022 Dec 20; Vol. 13 (6), pp. e0309622. Date of Electronic Publication: 2022 Nov 29.
Typ publikacji:
Journal Article
MeSH Terms:
Erythrocytes*/metabolism
Erythrocytes*/parasitology
Malaria*/genetics
Malaria*/metabolism
Malaria*/parasitology
Plasmodium berghei*/genetics
Plasmodium berghei*/metabolism
Protozoan Proteins*/genetics
Protozoan Proteins*/metabolism
Hepatocytes*/metabolism
Hepatocytes*/parasitology
Carcinoma, Hepatocellular ; Liver Neoplasms ; Plasmodium falciparum/genetics ; Protein Transport/genetics ; Protein Transport/physiology ; RNA, Catalytic/metabolism ; Animals ; Mice
Czasopismo naukowe
Szczegóły
Tytuł:
Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO/iNOS/NF-κB signaling pathway to maintain stable immune function.
Autorzy:
Gao M; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Yang N; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Lei Y; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Zhang W; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Liu H; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China.
Lin H; College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address: .
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Źródło:
Fish & shellfish immunology [Fish Shellfish Immunol] 2022 Dec; Vol. 131, pp. 1075-1084. Date of Electronic Publication: 2022 Nov 14.
Typ publikacji:
Journal Article
MeSH Terms:
Atrazine*/toxicity
Carps*/metabolism
DNA Damage*
Hepatocytes*/drug effects
Hepatocytes*/metabolism
Animals ; Autophagy ; Immunity ; NF-kappa B/metabolism ; Signal Transduction
Czasopismo naukowe
Szczegóły
Tytuł:
Discovery and SAR analysis of phenylbenzo[d][1,3]dioxole-based proprotein convertase subtilisin/kexin type 9 inhibitors.
Autorzy:
Li F; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Zhang L; School of Stomatology, Weifang Medical University, Weifang, China.
Feng J; Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 2017-2035.
Typ publikacji:
Journal Article
MeSH Terms:
Dioxoles*/pharmacology
Hepatocytes*/drug effects
Hepatocytes*/enzymology
PCSK9 Inhibitors*/pharmacology
Proprotein Convertase 9*/metabolism
Subtilisins*/antagonists & inhibitors
Subtilisins*/metabolism
Hep G2 Cells ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 54051

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