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Wyszukujesz frazę ""Hepatocytes"" wg kryterium: Temat


Tytuł:
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes.
Autorzy:
Yang S; Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.; Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.; Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Liu C; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Jiang M; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
Liu X; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
Geng L; Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.; Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Zhang Y; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
Sun S; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
Wang K; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Yin J; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Ma S; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
Wang S; Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.; Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Belmonte JCI; Altos Labs, Inc., San Diego, CA 94022, USA.
Zhang W; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; Aging Biomarker Consortium, Beijing 100101, China.
Qu J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.; Aging Biomarker Consortium, Beijing 100101, China.
Liu GH; Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.; Xuanwu Hospital Capital Medical University, Beijing 100053, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.; Aging Biomarker Consortium, Beijing 100101, China.
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Źródło:
Protein & cell [Protein Cell] 2024 Feb 01; Vol. 15 (2), pp. 98-120.
Typ publikacji:
Journal Article
MeSH Terms:
Liver*/metabolism
Hepatocytes*/metabolism
Animals ; Humans ; Aged ; Primates/genetics ; Gene Expression Profiling ; Aging/genetics
Czasopismo naukowe
Tytuł:
Distinct lactate metabolism between hepatocytes and myotubes revealed by live cell imaging with genetically encoded indicators.
Autorzy:
Horikoshi M; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8654, Japan.
Harada K; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
Tsuno S; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan; Dairy Science and Technology Institute, Kyodo Milk Industry Co., Ltd., 20-1 Hirai, Hinode, Tokyo 190-0182, Japan.
Kitaguchi T; Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan.
Hirai MY; RIKEN Center for Sustainable Resource Science, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama-city, Kanagawa, 230-0045, Japan.
Matsumoto M; Dairy Science and Technology Institute, Kyodo Milk Industry Co., Ltd., 20-1 Hirai, Hinode, Tokyo 190-0182, Japan.
Terada S; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan.
Tsuboi T; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8654, Japan; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo, 153-8902, Japan. Electronic address: .
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Źródło:
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jan 29; Vol. 694, pp. 149416. Date of Electronic Publication: 2023 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*/metabolism
Glucose*/metabolism
Muscle Fibers, Skeletal/metabolism ; Lactic Acid ; Adenosine Triphosphate/metabolism ; Pyruvates
Czasopismo naukowe
Tytuł:
L-Dopa decarboxylase modulates autophagy in hepatocytes and is implicated in dengue virus-caused inhibition of autophagy completion.
Autorzy:
Tsopela V; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Korakidis E; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Lagou D; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Kalliampakou KI; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Milona RS; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Kyriakopoulou E; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Mpekoulis G; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Gemenetzi I; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Stylianaki EA; Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, 16672 Athens, Greece.
Sideris CD; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Sioli A; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Kefallinos D; School of Electrical Engineering and Computer Science, National Technical University of Athens, 157 73 Athens, Greece.
Sideris DC; Section of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 157 01 Athens, Greece.
Aidinis V; Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, 16672 Athens, Greece.
Eliopoulos AG; Department of Biology, School of Medicine, NKUA, 115 27 Athens, Greece; Center of Basic Research, Biomedical Research Foundation Academy of Athens, 115 27 Athens, Greece.
Kambas K; Laboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, 115 21 Athens, Greece.
Vassilacopoulou D; Section of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, 157 01 Athens, Greece.
Vassilaki N; Laboratory of Molecular Virology, Hellenic Pasteur Institute, 115 21 Athens, Greece. Electronic address: .
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Źródło:
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2024 Jan; Vol. 1871 (1), pp. 119602. Date of Electronic Publication: 2023 Sep 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Dengue Virus*/metabolism
Hepatocytes*/pathology
Hepatocytes*/virology
Humans ; Dopa Decarboxylase/genetics ; Dopa Decarboxylase/metabolism ; Dopamine/metabolism
Czasopismo naukowe
Tytuł:
Application of improved GalNAc conjugation in development of cost-effective siRNA therapies targeting cardiovascular diseases.
Autorzy:
Li Q; Genoval Therapeutics Co., Ltd, Shanghai, China.
Yin K; Genoval Therapeutics Co., Ltd, Shanghai, China.
Ma HP; Genoval Therapeutics Co., Ltd, Shanghai, China.
Liu HH; Cardiometabolic Center, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, National Clinical Research Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Heart Failure Center, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, National Clinical Research Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Li S; Cardiometabolic Center, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, National Clinical Research Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Luo X; Genoval Therapeutics Co., Ltd, Shanghai, China.
Hu R; Genoval Therapeutics Co., Ltd, Shanghai, China.
Zhang WW; Genoval Therapeutics Co., Ltd, Shanghai, China.
Lv ZS; Genoval Therapeutics Co., Ltd, Shanghai, China.
Niu XL; Genoval Therapeutics Co., Ltd, Shanghai, China.
Gu MH; Genoval Therapeutics Co., Ltd, Shanghai, China.
Li CL; Genoval Therapeutics Co., Ltd, Shanghai, China.
Liu YS; Genoval Therapeutics Co., Ltd, Shanghai, China.
Liu YJ; Genoval Therapeutics Co., Ltd, Shanghai, China.
Li HB; Genoval Therapeutics Co., Ltd, Shanghai, China.
Li N; Genoval Therapeutics Co., Ltd, Shanghai, China.
Li C; Genoval Therapeutics Co., Ltd, Shanghai, China.
Gu WW; Genoval Therapeutics Co., Ltd, Shanghai, China. Electronic address: .
Li JJ; Cardiometabolic Center, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, National Clinical Research Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: .
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Źródło:
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Mar 06; Vol. 32 (3), pp. 637-645. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*
Cardiovascular Diseases*
Humans ; RNA, Small Interfering/genetics ; RNA, Small Interfering/chemistry ; Cost-Benefit Analysis ; RNA, Double-Stranded ; Acetylgalactosamine/chemistry ; Angiopoietin-Like Protein 3
Czasopismo naukowe
Tytuł:
Prediction of Human Clearance Using In Silico Models with Reduced Bias.
Autorzy:
Lombardo F; CmaxDMPK, LLC, Framingham , Massachusetts 01701, United States.
Bentzien J; Alkermes Inc., 852 Winter Street, Waltham, Massachusetts 02451, United States.
Berellini G; Alkermes Inc., 852 Winter Street, Waltham, Massachusetts 02451, United States.
Muegge I; Alkermes Inc., 852 Winter Street, Waltham, Massachusetts 02451, United States.
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Źródło:
Molecular pharmaceutics [Mol Pharm] 2024 Mar 04; Vol. 21 (3), pp. 1192-1203. Date of Electronic Publication: 2024 Jan 29.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*
Models, Biological*
Animals ; Humans ; Metabolic Clearance Rate ; Prospective Studies ; Computer Simulation ; Administration, Intravenous
Czasopismo naukowe
Tytuł:
The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability.
Autorzy:
Vlasveld M; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Callegaro G; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Fisher C; Certara UK Limited (Simcyp Division), Sheffield, UK.
Eakins J; Cyprotex Discovery Ltd., Macclesfield, UK.
Walker P; Cyprotex Discovery Ltd., Macclesfield, UK.
Lok S; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
van Oost S; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
de Jong B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Pellegrino-Coppola D; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Burger G; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Wink S; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
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Źródło:
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2024 Mar; Vol. 44 (3), pp. 760-775. Date of Electronic Publication: 2024 Jan 13.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*/metabolism
Chemical and Drug Induced Liver Injury*/genetics
Chemical and Drug Induced Liver Injury*/metabolism
Humans ; Hep G2 Cells ; Oxidative Stress ; Gene Expression Profiling
Czasopismo naukowe
Tytuł:
3D Spheroids Facilitate Differentiation of Human Adipose-Derived Mesenchymal Stem Cells into Hepatocyte-Like Cells via p300-Mediated H3K56 Acetylation.
Autorzy:
Yu Y; Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering in Jiangxi Province, Gannan Medical University, Ganzhou, People's Republic of China.; Center for Molecular Diagnosis and Precision Medicine, and Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
Huang H; Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering in Jiangxi Province, Gannan Medical University, Ganzhou, People's Republic of China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, People's Republic of China.
Ye J; Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering in Jiangxi Province, Gannan Medical University, Ganzhou, People's Republic of China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, People's Republic of China.; Subcenter for Stem Cell Clinical Translation, The First Affiliated Hospital of Gannan Medical University, Ganzhou, People's Republic of China.
Li Y; Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering in Jiangxi Province, Gannan Medical University, Ganzhou, People's Republic of China.; School of Basic Medicine, Gannan Medical University, Ganzhou, People's Republic of China.
Xie R; Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering in Jiangxi Province, Gannan Medical University, Ganzhou, People's Republic of China.; School of Medical Information Engineering, Gannan Medical University, Ganzhou, People's Republic of China.
Zeng L; Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering in Jiangxi Province, Gannan Medical University, Ganzhou, People's Republic of China.
Huang Y; Center for Evidence Based Medical and Clinical Research, The First Affiliated Hospital of Gannan Medical University, Ganzhou, People's Republic of China.
Zeng T; Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering in Jiangxi Province, Gannan Medical University, Ganzhou, People's Republic of China.
Luo D; Department of Physiology, School of Basic Medicine, Nanchang University, Nanchang, People's Republic of China.
Zhong J; Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering in Jiangxi Province, Gannan Medical University, Ganzhou, People's Republic of China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, People's Republic of China.
Peng W; Key Laboratory of Biomaterials and Biofabrication for Tissue Engineering in Jiangxi Province, Gannan Medical University, Ganzhou, People's Republic of China.; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, People's Republic of China.
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Źródło:
Stem cells translational medicine [Stem Cells Transl Med] 2024 Feb 14; Vol. 13 (2), pp. 151-165.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*
Mesenchymal Stem Cells*
Humans ; Acetylation ; Cell Differentiation ; Cells, Cultured
Czasopismo naukowe
Tytuł:
Phenotypic characterization of liver tissue heterogeneity through a next-generation 3D single-cell atlas.
Autorzy:
Martínez-Torres D; Department of Cell Biology, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile.; Grupo de Procesos en Biología del Desarrollo (GDeP), Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile.
Maldonado V; Department of Cell Biology, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile.; Grupo de Procesos en Biología del Desarrollo (GDeP), Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile.
Pérez-Gallardo C; Department of Cell Biology, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile.; Grupo de Procesos en Biología del Desarrollo (GDeP), Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile.
Yañez R; Department of Cell Biology, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile.; Grupo de Procesos en Biología del Desarrollo (GDeP), Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile.
Candia V; Department of Cell Biology, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile.; Grupo de Procesos en Biología del Desarrollo (GDeP), Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile.
Kalaidzidis Y; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Zerial M; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Morales-Navarrete H; Department of Systems Biology of Development, University of Konstanz, Konstanz, Germany. .; Facultad de Ciencias Técnicas, Universidad Internacional Del Ecuador UIDE, Quito, Ecuador. .
Segovia-Miranda F; Department of Cell Biology, Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile. .; Grupo de Procesos en Biología del Desarrollo (GDeP), Faculty of Biological Sciences, Universidad de Concepción, Concepción, Chile. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 03; Vol. 14 (1), pp. 2823. Date of Electronic Publication: 2024 Feb 03.
Typ publikacji:
Journal Article
MeSH Terms:
Liver*/pathology
Hepatocytes*
Mice ; Animals ; Kupffer Cells/pathology ; Hepatic Stellate Cells/pathology ; Bile Canaliculi
Czasopismo naukowe
Tytuł:
The choice of ultra-low attachment plates impacts primary human and primary canine hepatocyte spheroid formation, phenotypes, and function.
Autorzy:
Xing C; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Kemas A; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Mickols E; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Klein K; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany.
Artursson P; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany.
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Źródło:
Biotechnology journal [Biotechnol J] 2024 Feb; Vol. 19 (2), pp. e2300587.
Typ publikacji:
Journal Article
MeSH Terms:
Spheroids, Cellular*
Hepatocytes*/metabolism
Humans ; Animals ; Dogs ; Reproducibility of Results ; Liver ; Phenotype
Czasopismo naukowe
Tytuł:
Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion.
Autorzy:
Chen Z; Degenerative Diseases Program, Center for Genetics and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla CA 92037, USA. Electronic address: .
Wang S; Degenerative Diseases Program, Center for Genetics and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla CA 92037, USA.
Pottekat A; Degenerative Diseases Program, Center for Genetics and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla CA 92037, USA.
Duffey A; Degenerative Diseases Program, Center for Genetics and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla CA 92037, USA.
Jang I; Degenerative Diseases Program, Center for Genetics and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla CA 92037, USA.
Chang BH; Section of Nephrology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cho J; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Finck BN; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Davidson NO; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Kaufman RJ; Degenerative Diseases Program, Center for Genetics and Aging Research, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd, La Jolla CA 92037, USA. Electronic address: .
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Źródło:
Molecular metabolism [Mol Metab] 2024 Feb; Vol. 80, pp. 101874. Date of Electronic Publication: 2024 Jan 09.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*/metabolism
Lipoproteins, VLDL*/metabolism
Thymine Nucleotides*
Animals ; Mice ; Apolipoproteins B/genetics ; Apolipoproteins B/metabolism ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Triglycerides/metabolism
Czasopismo naukowe
Tytuł:
Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation.
Autorzy:
Porat-Shliom N; Cell Biology and Imaging Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. Electronic address: .
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Źródło:
Current opinion in cell biology [Curr Opin Cell Biol] 2024 Feb; Vol. 86, pp. 102292. Date of Electronic Publication: 2023 Dec 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hepatocytes*
Liver*/metabolism
Cell Communication ; Transcriptome
Czasopismo naukowe
Tytuł:
Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy.
Autorzy:
Bai H; Xellar Biosystems, Cambridge, MA, 02458, USA.
Olson KNP; Xellar Biosystems, Cambridge, MA, 02458, USA.
Pan M; Xellar Biosystems, Cambridge, MA, 02458, USA.
Marshall T; Xellar Biosystems, Cambridge, MA, 02458, USA.
Singh H; Xellar Biosystems, Cambridge, MA, 02458, USA.
Ma J; Xellar Biosystems, Cambridge, MA, 02458, USA.
Gilbride P; Xellar Biosystems, Cambridge, MA, 02458, USA.
Yuan YC; Xellar Biosystems, Cambridge, MA, 02458, USA.
McCormack J; Xellar Biosystems, Cambridge, MA, 02458, USA.
Si L; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Maharjan S; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02142, USA.
Huang D; Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, P. R. China.
Qian X; Xellar Biosystems, Cambridge, MA, 02458, USA.
Livermore C; Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, 02115, USA.
Zhang YS; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02142, USA.
Xie X; Xellar Biosystems, Cambridge, MA, 02458, USA.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Feb; Vol. 11 (7), pp. e2304332. Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Microfluidics*/methods
Hepatocytes*
Humans ; Cell Culture Techniques, Three Dimensional ; Hydrogels
Czasopismo naukowe
Tytuł:
Nobiletin Alleviated Epithelial-Mesenchymal Transition of Hepatocytes in Liver Fibrosis Based on Autophagy-Hippo/YAP Pathway.
Autorzy:
Hao Y; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
Feng D; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
Ye H; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
Liao W; Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
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Źródło:
Molecular nutrition & food research [Mol Nutr Food Res] 2024 Feb; Vol. 68 (3), pp. e2300529. Date of Electronic Publication: 2023 Dec 03.
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Hepatocytes*
Flavones*
Mice ; Animals ; Liver Cirrhosis/drug therapy ; Liver/metabolism ; Epithelial-Mesenchymal Transition/physiology ; Autophagy
Czasopismo naukowe
Tytuł:
Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function.
Autorzy:
Lazzeri-Barcelo F; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden.
Oliva-Vilarnau N; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Baniol M; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
Leibiger B; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden.
Bergmann O; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.; Department of Pharmacology and Toxicology, University Medical Center Goettingen, Goettingen, Germany.
Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany.
Leibiger IB; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden.
Moruzzi N; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden. .
Berggren PO; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden.; Tecnológico de Monterrey, Monterrey, NL, Mexico.; Diabetes Research Institute, University of Miami. Miller School of Medicine, Miami, Fl, USA.
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Źródło:
Nature communications [Nat Commun] 2024 Jan 26; Vol. 15 (1), pp. 767. Date of Electronic Publication: 2024 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Liver*/metabolism
Hepatocytes*
Mice ; Animals ; Cell Physiological Phenomena ; Fluorescent Dyes/metabolism ; Spheroids, Cellular
Czasopismo naukowe
Tytuł:
Role of connexin 32 in the directional differentiation of induced pluripotent stem cells into hepatocytes.
Autorzy:
Xu Y; Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Wang Y; Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Qi R; Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Li K; Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Wang X; Department of Ultrasonography, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Li X; Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, 97239, USA.
Shi B; Department of General Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.; Department of General Surgery, Xinhua Hospital, School of medicine, Shanghai Jiaotong University, 200025, China.
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Źródło:
International journal of medical sciences [Int J Med Sci] 2024 Jan 12; Vol. 21 (3), pp. 508-518. Date of Electronic Publication: 2024 Jan 12 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation*
Gap Junction beta-1 Protein*/genetics
Hepatocytes*/cytology
Induced Pluripotent Stem Cells*/cytology
Down-Regulation ; Vitamin K 2 ; Humans
Czasopismo naukowe
Tytuł:
BRAIDing receptors for cell-specific targeting.
Autorzy:
Chen H; Surrozen Inc, South San Francisco, United States.
Lee SJ; Surrozen Inc, South San Francisco, United States.
Li R; Surrozen Inc, South San Francisco, United States.
Sura A; Surrozen Inc, South San Francisco, United States.
Suen N; Surrozen Inc, South San Francisco, United States.
Dilip A; Surrozen Inc, South San Francisco, United States.
Pomogov Y; Surrozen Inc, South San Francisco, United States.
Vuppalapaty M; Surrozen Inc, South San Francisco, United States.
Suen TT; Surrozen Inc, South San Francisco, United States.
Lu C; Surrozen Inc, South San Francisco, United States.
Post Y; Surrozen Inc, South San Francisco, United States.
Li Y; Surrozen Inc, South San Francisco, United States.
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Źródło:
ELife [Elife] 2024 Jan 09; Vol. 12. Date of Electronic Publication: 2024 Jan 09.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes*
Wnt Signaling Pathway*
Protein Transport ; Cell Movement ; Epitopes
Czasopismo naukowe
Tytuł:
Irreversible Electroporation of the Liver Increases the Transplant Engraftment of Hepatocytes.
Autorzy:
Han S; Department of Surgery, University of California, San Francisco, California.
Dicker ML; Department of Surgery, University of California, San Francisco, California.
Lopez-Ichikawa M; Department of Surgery, University of California, San Francisco, California.
Vu NK; Department of Surgery, University of California, San Francisco, California.
Rubinsky B; Department of Mechanical Engineering, University of California, Berkeley, California.
Chang TT; Department of Surgery, University of California, San Francisco, California; Liver Center, University of California, San Francisco, California. Electronic address: .
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Źródło:
The Journal of surgical research [J Surg Res] 2024 Jan; Vol. 293, pp. 128-135. Date of Electronic Publication: 2023 Sep 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Liver*/surgery
Hepatocytes*/transplantation
Mice ; Animals ; Electroporation ; Stem Cell Transplantation ; beta-Galactosidase
Czasopismo naukowe
Tytuł:
Reduction of alcohol-induced mitochondrial damage with ginsenoside Rg1 studied by atomic force microscopy.
Autorzy:
Zhang S; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China; Zhongshan Institute of hangchun University of Science and Technology, Zhongshan 528400, China; Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China.
Zeng Y; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China; Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China.
Wang B; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China; Zhongshan Institute of hangchun University of Science and Technology, Zhongshan 528400, China; Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China.
Li J; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China; Zhongshan Institute of hangchun University of Science and Technology, Zhongshan 528400, China; Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China.
Hu C; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China; Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China.
Weng Z; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China; Zhongshan Institute of hangchun University of Science and Technology, Zhongshan 528400, China. Electronic address: .
Wang Z; International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China; Zhongshan Institute of hangchun University of Science and Technology, Zhongshan 528400, China; Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China; JR3CN & IRAC, University of Bedfordshire, Luton LU1 3JU, UK. Electronic address: .
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Źródło:
Micron (Oxford, England : 1993) [Micron] 2023 Nov; Vol. 174, pp. 103522. Date of Electronic Publication: 2023 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ethanol*/toxicity
Ginsenosides*/pharmacology
Microscopy, Atomic Force*
Mitochondria*/drug effects
Mitochondria*/ultrastructure
Hepatocytes*/drug effects
Hepatocytes*/ultrastructure
Czasopismo naukowe
Tytuł:
3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation.
Autorzy:
Wesseler MF; Department of Health Technology, DTU Health Tech, Technical University of Denmark, Kgs, Lyngby, Denmark.
Taebnia N; Department of Health Technology, DTU Health Tech, Technical University of Denmark, Kgs, Lyngby, Denmark.
Harrison S; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.
Youhanna S; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Preiss LC; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Department of Drug Metabolism and Pharmacokinetics (DMPK), the healthcare business of Merck KGaA, Darmstadt, Germany.
Kemas AM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Vegvari A; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Mokry J; Department of Histology and Embryology, Faculty of Medicine in Hradec Králové, Charles University, Hradec, Králové, Czech Republic.
Sullivan GJ; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway. Electronic address: .
Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany. Electronic address: .
Larsen NB; Department of Health Technology, DTU Health Tech, Technical University of Denmark, Kgs, Lyngby, Denmark. Electronic address: .
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Źródło:
Acta biomaterialia [Acta Biomater] 2023 Nov; Vol. 171, pp. 336-349. Date of Electronic Publication: 2023 Sep 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Liver*
Hepatocytes*/metabolism
Humans ; Oxygen/metabolism ; Hydrogels/metabolism
Czasopismo naukowe
Tytuł:
Insulin-induced gene 2 protects against hepatic ischemia-reperfusion injury via metabolic remodeling.
Autorzy:
Wu Y; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.; NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, 310003, China.
Li C; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.; NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, 310003, China.
Khan AA; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.
Chen K; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.
Su R; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.
Xu S; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.
Sun Y; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.; The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Gao F; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.
Wang K; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.
Wang X; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.; The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Lian Z; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.
Wang S; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou, 311112, China.
Yu M; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.; The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Hu X; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.
Yang F; Zhejiang University School of Medicine, Hangzhou, 310058, China.; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China.
Zheng S; NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, 310003, China.; Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou, 311112, China.
Qiu N; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China. .
Liu Z; Zhejiang University School of Medicine, Hangzhou, 310058, China. .; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China. .
Xu X; Zhejiang University School of Medicine, Hangzhou, 310058, China. .; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou, 310006, China. .; NHC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou, 310003, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Oct 19; Vol. 21 (1), pp. 739. Date of Electronic Publication: 2023 Oct 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hepatocytes*/metabolism
Hepatocytes*/pathology
Insulins*/metabolism
Liver Diseases*/genetics
Liver Diseases*/metabolism
Liver Diseases*/pathology
Liver Diseases*/surgery
Reperfusion Injury*/genetics
Reperfusion Injury*/metabolism
Reperfusion Injury*/pathology
Reperfusion Injury*/prevention & control
Animals ; Mice ; Antioxidants/metabolism ; Apoptosis/genetics ; Glucose/metabolism ; Hepatectomy/adverse effects ; Hypoxia/complications ; Hypoxia/genetics ; Hypoxia/metabolism ; Liver/blood supply ; Liver/injuries ; Liver/metabolism ; Liver/pathology ; Liver Transplantation/adverse effects ; Phosphates/metabolism ; Phosphates/pharmacology
Czasopismo naukowe

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