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Tytuł :
Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail.
Autorzy :
Froude JW; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Herbert AS; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. andrew.s..
Pelat T; Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees (IRBA-CRSSA), La Tronche 38516, France. .
Miethe S; Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig 38106, Germany. .
Zak SE; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Brannan JM; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Bakken RR; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Steiner AR; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Yin G; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Hallam TJ; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Sato AK; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Hust M; Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig 38106, Germany. .
Thullier P; Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees (IRBA-CRSSA), La Tronche 38516, France. .
Dye JM; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
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Źródło :
Viruses [Viruses] 2018 May 26; Vol. 10 (6). Date of Electronic Publication: 2018 May 26.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ebolavirus*
Post-Exposure Prophylaxis*
Antibodies, Viral/*pharmacology
Hemorrhagic Fever, Ebola/*therapy
Membrane Glycoproteins/*immunology
Vaccines, Virus-Like Particle/*immunology
Viral Matrix Proteins/*immunology
Animals ; Antibodies, Neutralizing/pharmacology ; Cell Surface Display Techniques ; Cross Reactions ; Female ; Macaca ; Male ; Mice ; Mice, Knockout ; Single-Chain Antibodies/pharmacology ; Vaccination
Czasopismo naukowe
Tytuł :
NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.
Autorzy :
Raaben M; Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Jae LT; Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Virology Division, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Virology Division, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA.
Stubbs SH; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Chou YY; Department of Cell Biology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Blomen VA; Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Kirchhausen T; Department of Cell Biology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Virology Division, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA.
Brummelkamp TR; Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; CGC.nl; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 14 Vienna, Austria. Electronic address: .
Whelan SP; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2017 Nov 08; Vol. 22 (5), pp. 688-696.e5.
Typ publikacji :
Journal Article
MeSH Terms :
Virus Internalization*
Lujo virus/*physiology
Neuropilin-2/*metabolism
Tetraspanin 30/*metabolism
Viral Fusion Proteins/*metabolism
Viral Proteins/*metabolism
Carrier Proteins ; Cell Line ; Host-Pathogen Interactions/physiology ; Human Umbilical Vein Endothelial Cells ; Humans ; Lujo virus/genetics ; Lujo virus/pathogenicity ; Protein Interaction Domains and Motifs ; Receptors, Cell Surface/metabolism ; Receptors, Transferrin ; Viral Fusion Proteins/genetics ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
Marburg virus survivor immune responses are Th1 skewed with limited neutralizing antibody responses.
Autorzy :
Stonier SW; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD.
Herbert AS; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD.
Kuehne AI; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD.
Sobarzo A; Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Habibulin P; Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Dahan CVA; Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
James RM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD.
Egesa M; Uganda Research Unit on AIDS, Medical Research Council/Uganda Virus Research Institute, Entebbe, Uganda.; Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda.
Cose S; Uganda Research Unit on AIDS, Medical Research Council/Uganda Virus Research Institute, Entebbe, Uganda.; Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda.; London School of Hygiene & Tropical Medicine, London, England, UK.
Lutwama JJ; Department of Arbovirology, Emerging, and Re-emerging Infection, Uganda Virus Research Institute, Entebbe, Uganda.
Lobel L; Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.; Department of Arbovirology, Emerging, and Re-emerging Infection, Uganda Virus Research Institute, Entebbe, Uganda.
Dye JM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD .
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Źródło :
The Journal of experimental medicine [J Exp Med] 2017 Sep 04; Vol. 214 (9), pp. 2563-2572. Date of Electronic Publication: 2017 Jul 19.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Neutralizing/*immunology
Marburg Virus Disease/*immunology
Marburgvirus/*immunology
Th1 Cells/*immunology
Adolescent ; Adult ; Animals ; Antibodies, Viral/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD40 Ligand/metabolism ; CD8-Positive T-Lymphocytes/immunology ; Cytokines/metabolism ; Female ; Flow Cytometry ; Humans ; Immunity, Cellular/immunology ; Male ; Marburg Virus Disease/mortality ; Middle Aged ; Survivors ; Uganda/epidemiology ; Young Adult
Czasopismo naukowe
Tytuł :
Vesicular Stomatitis Virus Pseudotyped with Ebola Virus Glycoprotein Serves as a Protective, Noninfectious Vaccine against Ebola Virus Challenge in Mice.
Autorzy :
Lennemann NJ; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Brouillette R; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Rhein B; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Bakken RA; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Perschbacher KJ; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Cooney AL; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Miller-Hunt CL; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Ten Eyck P; Iowa Center for Clinical and Translational Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Biggins J; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Olinger G; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Maury W; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA .
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Źródło :
Journal of virology [J Virol] 2017 Aug 10; Vol. 91 (17). Date of Electronic Publication: 2017 Aug 10 (Print Publication: 2017).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Abelson DM; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
James RM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
de La Vega MA; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Goodwin E; Adimab, LLC, Lebanon, NH 03766, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
Bornholdt ZA; Mapp Biopharmaceutical, San Diego, CA 92121, USA. Electronic address: .
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Źródło :
Cell [Cell] 2017 May 18; Vol. 169 (5), pp. 878-890.e15.
Typ publikacji :
Journal Article
MeSH Terms :
Survivors*
Antibodies, Neutralizing/*isolation & purification
Antibodies, Viral/*isolation & purification
Ebola Vaccines/*immunology
Hemorrhagic Fever, Ebola/*immunology
Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Chlorocebus aethiops ; Cross Reactions ; Ebolavirus/classification ; Ebolavirus/immunology ; Female ; Ferrets ; Hemorrhagic Fever, Ebola/virology ; Humans ; Kinetics ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Sequence Alignment ; Vero Cells
Czasopismo naukowe
Tytuł :
Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease.
Autorzy :
Kash JC; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Walters KA; Institute for Systems Biology, Seattle, WA 98109, USA.
Kindrachuk J; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA.
Baxter D; Institute for Systems Biology, Seattle, WA 98109, USA.
Scherler K; Institute for Systems Biology, Seattle, WA 98109, USA.
Janosko KB; Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Adams RD; Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
James RM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Stonier SW; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Memoli MJ; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Davey RT Jr; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Chertow DS; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA.
Taubenberger JK; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. .
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Źródło :
Science translational medicine [Sci Transl Med] 2017 Apr 12; Vol. 9 (385).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Intramural
MeSH Terms :
Ebolavirus/*pathogenicity
Hemorrhagic Fever, Ebola/*virology
Leukocytes/*metabolism
Disease Outbreaks ; Hemorrhagic Fever, Ebola/blood ; Humans ; Longitudinal Studies ; RNA, Viral/blood ; RNA, Viral/genetics ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus.
Autorzy :
Howell KA; Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA.
Brannan JM; US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702-5011, USA.
Bryan C; Integral Molecular, Philadelphia, PA 19104, USA.
McNeal A; Integral Molecular, Philadelphia, PA 19104, USA.
Davidson E; Integral Molecular, Philadelphia, PA 19104, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Vu H; Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA.
Shulenin S; Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Kuehne A; US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702-5011, USA.
Herbert AS; US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702-5011, USA.
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Doranz BJ; Integral Molecular, Philadelphia, PA 19104, USA.
Holtsberg FW; Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702-5011, USA.
Aman MJ; Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2017 Apr 11; Vol. 19 (2), pp. 413-424.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Animals ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/therapeutic use ; Drug Synergism ; Ebolavirus/pathogenicity ; Hemorrhagic Fever, Ebola/therapy ; Hemorrhagic Fever, Ebola/virology ; Humans ; Mice
Czasopismo naukowe
Tytuł :
A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Howell KA; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Holtsberg FW; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Christin JR; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Shulenin S; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bharrhan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.
Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 10550, USA.
Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA. .; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Aman MJ; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. .
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. .
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2016 Oct 21; Vol. 354 (6310), pp. 350-354. Date of Electronic Publication: 2016 Sep 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Carrier Proteins/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Membrane Glycoproteins/*immunology
Receptors, Virus/*immunology
Viral Envelope Proteins/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Binding Sites/immunology ; Cell Line, Tumor ; Endosomes/virology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunotherapy/methods ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Inbred BALB C ; Virus Internalization
Czasopismo naukowe
Tytuł :
Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site.
Autorzy :
Howell KA; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Deparment of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Brannan JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Bryan C; Integral Molecular, Philadelphia, PA 19104, USA.
Davidson E; Integral Molecular, Philadelphia, PA 19104, USA.
Holtsberg FW; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Shulenin S; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Biggins JE; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Douglas R; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Enterlein SG; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Pallesen J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Deparment of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Kroeker A; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Deparment of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Vu H; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Keck ZY; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Foung SKH; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Doranz BJ; Integral Molecular, Philadelphia, PA 19104, USA.
Kobinger GP; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Deparment of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Aman MJ; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2016 May 17; Vol. 15 (7), pp. 1514-1526. Date of Electronic Publication: 2016 May 05.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Ebolavirus/*physiology
Epitopes/*immunology
Glycoproteins/*metabolism
Hemorrhagic Fever, Ebola/*immunology
Receptors, Virus/*metabolism
Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/ultrastructure ; Antibodies, Neutralizing ; Antibodies, Viral/chemistry ; Binding Sites ; Disease Models, Animal ; Female ; Glycoproteins/chemistry ; Glycoproteins/genetics ; Glycoproteins/ultrastructure ; Guinea Pigs ; HEK293 Cells ; Humans ; Kinetics ; Mice, Inbred BALB C ; Models, Molecular ; Mutation/genetics ; Negative Staining ; Neutralization Tests ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors.
Autorzy :
Sobarzo A; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Stonier SW; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. .
Herbert AS; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. anderw.s.herbert..
Ochayon DE; Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Kuehne AI; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. .
Eskira Y; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Fedida-Metula S; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Tali N; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Lewis EC; Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Egesa M; Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe P.O. Box 49, Uganda. .; Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala P.O. Box 7072, Uganda. .
Cose S; Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe P.O. Box 49, Uganda. .; London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. .
Lutwama JJ; Department of Arbovirology, Emerging and Re-Emerging Infection Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda. .
Yavelsky V; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Dye JM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. .
Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
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Źródło :
Viruses [Viruses] 2016 May 11; Vol. 8 (5). Date of Electronic Publication: 2016 May 11.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*blood
Antibodies, Viral/*blood
CD4-Positive T-Lymphocytes/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Cytokines/biosynthesis ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Humans ; Neutralization Tests ; Survivors ; Uganda
Czasopismo naukowe
Tytuł :
Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle.
Autorzy :
Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Wu H; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
Hooper JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Kuehne AI; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Coyle EM; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Ortiz RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Fuentes S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Herbert AS; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Golding H; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Bakken RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Brannan JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Kwilas SA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Sullivan EJ; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
Luke TC; Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation, Silver Spring, Maryland, USA.
Smith G; Novavax Inc, Gaithersburg, Maryland, USA.
Glenn G; Novavax Inc, Gaithersburg, Maryland, USA.
Li W; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Ye L; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Yang C; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Compans RW; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Tripp RA; The University of Georgia, Athens, Georgia, 30602, USA.
Jiao JA; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
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Źródło :
Scientific reports [Sci Rep] 2016 Apr 25; Vol. 6, pp. 24897. Date of Electronic Publication: 2016 Apr 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Animals, Genetically Modified*
Cattle*
Antibodies, Viral/*blood
Antibodies, Viral/*therapeutic use
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animals ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunization, Passive ; Immunoglobulin G/blood ; Immunoglobulin G/therapeutic use ; Mice, Inbred BALB C ; Neutralization Tests ; Surface Plasmon Resonance ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles.
Autorzy :
Ndungo E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Raaben M; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA; Netherlands Cancer Institute, Amsterdam, The Netherlands.
Obernosterer G; Netherlands Cancer Institute, Amsterdam, The Netherlands.
Biswas R; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Miller EH; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Wirchnianski AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Carette JE; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Brummelkamp TR; Netherlands Cancer Institute, Amsterdam, The Netherlands.
Whelan SP; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
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Źródło :
MSphere [mSphere] 2016 Mar 30; Vol. 1 (2). Date of Electronic Publication: 2016 Mar 30 (Print Publication: 2016).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Cysteine Cathepsin Inhibitors as Anti-Ebola Agents.
Autorzy :
van der Linden WA; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, United States.
Schulze CJ; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, United States.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, United States.
Krause TB; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Wirchnianski AA; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, United States.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, United States.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, United States.
Bogyo M; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, United States.
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Źródło :
ACS infectious diseases [ACS Infect Dis] 2016 Mar 11; Vol. 2 (3), pp. 173-179. Date of Electronic Publication: 2016 Jan 20.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.
Autorzy :
Ng M; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
Ndungo E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
Kaczmarek ME; Department of Integrative Biology, University of Texas at Austin, Austin, United States.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States.
Binger T; Institute of Virology, University of Bonn Medical Center, Bonn, Germany.
Kuehne AI; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
Hawkins JA; Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, United States.
Gifford RJ; University of Glasgow MRC Virology Unit, Glasgow, United Kingdom.
Biswas R; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
Demogines A; Department of Molecular Biosciences, University of Texas at Austin, Austin, United States.
James RM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States.
Yu M; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, , Singapore.
Brummelkamp TR; Netherlands Cancer Institute, Plesmanlaan, The Netherlands.
Drosten C; Institute of Virology, University of Bonn Medical Center, Bonn, Germany.; German Centre for Infectious Diseases Research, Bonn, Germany.
Wang LF; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, , Singapore.
Kuhn JH; Integrated Research Facility at Fort Detrick, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, United States.
Müller MA; Institute of Virology, University of Bonn Medical Center, Bonn, Germany.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States.
Sawyer SL; Department of Molecular Biosciences, University of Texas at Austin, Austin, United States.; BioFrontiers Institute, University of Colorado Boulder, Boulder, United States.; Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, United States.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
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Źródło :
ELife [Elife] 2015 Dec 23; Vol. 4. Date of Electronic Publication: 2015 Dec 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Host Specificity*
Virus Attachment*
Filoviridae/*physiology
Membrane Glycoproteins/*metabolism
Receptors, Virus/*metabolism
Animals ; Cell Line ; Chiroptera
Czasopismo naukowe
Tytuł :
Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein.
Autorzy :
Keck ZY; Department of Pathology, Stanford University, Stanford, California, USA.
Enterlein SG; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Howell KA; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Vu H; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Shulenin S; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Warfield KL; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Froude JW; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Araghi N; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Douglas R; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Biggins J; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Lear-Rooney CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Wirchnianski AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Lau P; Department of Pathology, Stanford University, Stanford, California, USA.
Wang Y; Department of Pathology, Stanford University, Stanford, California, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Glass PJ; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Holtsberg FW; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Foung SK; Department of Pathology, Stanford University, Stanford, California, USA.
Aman MJ; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA .
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Źródło :
Journal of virology [J Virol] 2015 Oct 14; Vol. 90 (1), pp. 279-91. Date of Electronic Publication: 2015 Oct 14 (Print Publication: 2016).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Epitopes/*immunology
Filoviridae/*immunology
Glycoproteins/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Viral Proteins/*immunology
Animals ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/isolation & purification ; Antibodies, Viral/therapeutic use ; Cross Reactions ; Disease Models, Animal ; Female ; Immunization, Passive ; Macaca ; Mice, Inbred BALB C ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses.
Autorzy :
Holtsberg FW; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Shulenin S; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Vu H; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Howell KA; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Patel SJ; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Gunn B; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, Massachusetts, USA.
Karim M; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, Massachusetts, USA.
Lai JR; Albert Einstein College of Medicine, New York, New York, USA.
Frei JC; Albert Einstein College of Medicine, New York, New York, USA.
Nyakatura EK; Albert Einstein College of Medicine, New York, New York, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, California, USA.
Douglas R; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Froude JW; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Wirchnianski AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Lear-Rooney CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Alter G; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, Massachusetts, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Glass PJ; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Warfield KL; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Aman MJ; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA .
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Źródło :
Journal of virology [J Virol] 2015 Oct 14; Vol. 90 (1), pp. 266-78. Date of Electronic Publication: 2015 Oct 14 (Print Publication: 2016).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunization, Passive*
Antibodies, Monoclonal/*immunology
Antibodies, Monoclonal/*isolation & purification
Antibodies, Viral/*immunology
Antibodies, Viral/*isolation & purification
Filoviridae/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/administration & dosage ; Cross Protection ; Disease Models, Animal ; Epitopes/immunology ; Female ; Mice, Inbred BALB C ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Novel Small Molecule Entry Inhibitors of Ebola Virus.
Autorzy :
Basu A; Microbiotix, Inc, Worcester, Massachusetts.
Mills DM; Microbiotix, Inc, Worcester, Massachusetts.
Mitchell D; Texas Biomedical Research Institute, San Antonio.
Ndungo E; Albert Einstein College of Medicine, Bronx, New York.
Williams JD; Microbiotix, Inc, Worcester, Massachusetts.
Herbert AS; Army Medical Research Institute of Infectious Diseases, Frederick, Maryland.
Dye JM; Army Medical Research Institute of Infectious Diseases, Frederick, Maryland.
Moir DT; Microbiotix, Inc, Worcester, Massachusetts.
Chandran K; Albert Einstein College of Medicine, Bronx, New York.
Patterson JL; Texas Biomedical Research Institute, San Antonio.
Rong L; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago.
Bowlin TL; Microbiotix, Inc, Worcester, Massachusetts.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2015 Oct 01; Vol. 212 Suppl 2, pp. S425-34. Date of Electronic Publication: 2015 Jul 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antiviral Agents/*pharmacology
Ebolavirus/*drug effects
Hemorrhagic Fever, Ebola/*drug therapy
Hemorrhagic Fever, Ebola/*virology
Small Molecule Libraries/*pharmacology
Animals ; Carrier Proteins/metabolism ; Cell Line ; Chlorocebus aethiops ; Glycoproteins/metabolism ; HEK293 Cells ; Humans ; Intracellular Signaling Peptides and Proteins ; Membrane Glycoproteins/metabolism ; Protein Binding/drug effects ; Vero Cells ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion.
Autorzy :
Kleinfelter LM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Jae LT; Netherlands Cancer Institute, Amsterdam, The Netherlands.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Stiles KM; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.
Wirchnianski AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Kielian M; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.
Brummelkamp TR; Netherlands Cancer Institute, Amsterdam, The Netherlands.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA .
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Źródło :
MBio [mBio] 2015 Jun 30; Vol. 6 (4), pp. e00801. Date of Electronic Publication: 2015 Jun 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Virus Internalization*
Cholesterol/*metabolism
Hantavirus/*physiology
Animals ; Chlorocebus aethiops ; Genetic Testing ; HEK293 Cells ; Haploidy ; Humans ; Vero Cells
Czasopismo naukowe
Tytuł :
Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.
Autorzy :
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Davidson C; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Bakken R; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Braigen SZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Gunn KE
Whelan SP; Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Brummelkamp TR; Netherlands Cancer Institute, Amsterdam, The Netherlands.
Twenhafel NA; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA .
Walkley SU; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA .
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA .
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Źródło :
MBio [mBio] 2015 May 26; Vol. 6 (3), pp. e00565-15. Date of Electronic Publication: 2015 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Host-Pathogen Interactions*
Virus Replication*
Ebolavirus/*physiology
Hemorrhagic Fever, Ebola/*virology
Proteins/*metabolism
Animals ; Cholesterol/metabolism ; Disease Models, Animal ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Knockout ; Proteins/genetics ; Vesicular Transport Proteins/deficiency ; Vesicular Transport Proteins/metabolism
Czasopismo naukowe
Tytuł :
Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.
Autorzy :
Clinton TR; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, 84112-5650.
Weinstock MT
Jacobsen MT
Szabo-Fresnais N
Pandya MJ
Whitby FG
Herbert AS
Prugar LI
McKinnon R
Hill CP
Welch BD
Dye JM
Eckert DM
Kay MS
Pokaż więcej
Źródło :
Protein science : a publication of the Protein Society [Protein Sci] 2015 Apr; Vol. 24 (4), pp. 446-63. Date of Electronic Publication: 2014 Oct 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ebolavirus/*chemistry
Viral Envelope Proteins/*chemistry
Viral Envelope Proteins/*metabolism
Amino Acid Sequence ; Drug Delivery Systems ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Sequence Alignment ; Viral Envelope Proteins/genetics
Czasopismo naukowe

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