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    Tytuł:
    A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
    Autorzy:
    Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
    Howell KA; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
    Holtsberg FW; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
    Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
    Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Christin JR; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Shulenin S; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
    Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Bharrhan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
    Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.
    Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA.
    Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 10550, USA.
    Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA. .; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
    Aman MJ; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. .
    Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. .
    Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
    Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
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    Źródło:
    Science (New York, N.Y.) [Science] 2016 Oct 21; Vol. 354 (6310), pp. 350-354. Date of Electronic Publication: 2016 Sep 08.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antibodies, Bispecific/*immunology
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    Carrier Proteins/*immunology
    Ebolavirus/*immunology
    Hemorrhagic Fever, Ebola/*prevention & control
    Membrane Glycoproteins/*immunology
    Receptors, Virus/*immunology
    Viral Envelope Proteins/*immunology
    Animals ; Antibodies, Monoclonal/immunology ; Binding Sites/immunology ; Cell Line, Tumor ; Endosomes/virology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunotherapy/methods ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Inbred BALB C ; Niemann-Pick C1 Protein ; Virus Internalization
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes.
    Autorzy:
    Voss WN; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Hou YJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Delidakis G; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
    Kim JE; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
    Javanmardi K; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Horton AP; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Bartzoka F; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Paresi CJ; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA.
    Tanno Y; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
    Chou CW; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA.
    Pickens W; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    George K; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Boutz DR; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; CCDC Army Research Laboratory-South, The University of Texas at Austin, Austin, TX, USA.
    Towers DM; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
    McDaniel JR; Biomedicine Design, Pfizer, Cambridge, MA, USA.
    Billick D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Goike J; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Rowe L; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.; Tulane National Primate Research Center Department of Microbiology 18703 Three Rivers Road Covington, LA, USA.
    Batra D; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
    Pohl J; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
    Lee J; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
    Gangappa S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
    Sambhara S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
    Gadush M; Center for Biomedical Research Support, The University of Texas at Austin, Austin, TX, USA.
    Wang N; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Person MD; Center for Biomedical Research Support, The University of Texas at Austin, Austin, TX, USA.
    Iverson BL; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA.
    Gollihar JD; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; CCDC Army Research Laboratory-South, The University of Texas at Austin, Austin, TX, USA.; Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.
    Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA.
    Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA.
    Finkelstein IJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
    Georgiou G; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.; Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
    Lavinder JJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. .; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
    Ippolito GC; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. .; Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.; Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2021 Jun 04; Vol. 372 (6546), pp. 1108-1112. Date of Electronic Publication: 2021 May 04.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Antibodies, Neutralizing/*immunology
    Antibodies, Viral/*immunology
    COVID-19/*immunology
    Immunoglobulin G/*immunology
    SARS-CoV-2/*immunology
    Spike Glycoprotein, Coronavirus/*immunology
    Animals ; Antibodies, Monoclonal/blood ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/chemistry ; Antibodies, Viral/blood ; Antibodies, Viral/chemistry ; Antibody Affinity ; COVID-19/prevention & control ; Epitopes/immunology ; Humans ; Immune Evasion ; Immunoglobulin G/blood ; Immunoglobulin G/chemistry ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Variable Region/immunology ; Mice ; Mice, Inbred BALB C ; Mutation ; Protein Domains ; Proteomics ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail.
    Autorzy:
    Froude JW; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
    Herbert AS; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. andrew.s..
    Pelat T; Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees (IRBA-CRSSA), La Tronche 38516, France. .
    Miethe S; Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig 38106, Germany. .
    Zak SE; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
    Brannan JM; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
    Bakken RR; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
    Steiner AR; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
    Yin G; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
    Hallam TJ; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
    Sato AK; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
    Hust M; Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig 38106, Germany. .
    Thullier P; Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees (IRBA-CRSSA), La Tronche 38516, France. .
    Dye JM; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
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    Źródło:
    Viruses [Viruses] 2018 May 26; Vol. 10 (6). Date of Electronic Publication: 2018 May 26.
    Typ publikacji:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Ebolavirus*
    Post-Exposure Prophylaxis*
    Antibodies, Viral/*pharmacology
    Hemorrhagic Fever, Ebola/*therapy
    Membrane Glycoproteins/*immunology
    Vaccines, Virus-Like Particle/*immunology
    Viral Matrix Proteins/*immunology
    Animals ; Antibodies, Neutralizing/pharmacology ; Cell Surface Display Techniques ; Cross Reactions ; Female ; Macaca ; Male ; Mice ; Mice, Knockout ; Single-Chain Antibodies/pharmacology ; Vaccination
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle.
    Autorzy:
    Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
    Wu H; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
    Hooper JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
    Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
    Kuehne AI; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
    Coyle EM; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
    Ortiz RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
    Fuentes S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
    Herbert AS; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
    Golding H; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
    Bakken RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
    Brannan JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
    Kwilas SA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
    Sullivan EJ; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
    Luke TC; Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation, Silver Spring, Maryland, USA.
    Smith G; Novavax Inc, Gaithersburg, Maryland, USA.
    Glenn G; Novavax Inc, Gaithersburg, Maryland, USA.
    Li W; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
    Ye L; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
    Yang C; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
    Compans RW; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
    Tripp RA; The University of Georgia, Athens, Georgia, 30602, USA.
    Jiao JA; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
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    Źródło:
    Scientific reports [Sci Rep] 2016 Apr 25; Vol. 6, pp. 24897. Date of Electronic Publication: 2016 Apr 25.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Animals, Genetically Modified*
    Cattle*
    Antibodies, Viral/*blood
    Antibodies, Viral/*therapeutic use
    Ebolavirus/*immunology
    Hemorrhagic Fever, Ebola/*prevention & control
    Animals ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunization, Passive ; Immunoglobulin G/blood ; Immunoglobulin G/therapeutic use ; Mice, Inbred BALB C ; Neutralization Tests ; Surface Plasmon Resonance ; Treatment Outcome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Immune memory to Sudan virus: comparison between two separate disease outbreaks.
    Autorzy:
    Sobarzo A; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. .
    Eskira Y; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. .
    Herbert AS; Virology Division-U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. anderw.s.herbert..
    Kuehne AI; Virology Division-U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. .
    Stonier SW; Virology Division-U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. spencer.w.stonier2..
    Ochayon DE; Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. .
    Fedida-Metula S; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. .
    Balinandi S; Department of Arbovirology, Emerging and Re-emerging Infection Uganda Virus Research Institute, Entebbe P.O Box 49, Uganda. .
    Kislev Y; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. .
    Tali N; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. .
    Lewis EC; Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. .
    Lutwama JJ; Department of Arbovirology, Emerging and Re-emerging Infection Uganda Virus Research Institute, Entebbe P.O Box 49, Uganda. .
    Dye JM; Virology Division-U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. .
    Yavelsky V; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. .
    Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. .
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    Źródło:
    Viruses [Viruses] 2015 Jan 06; Vol. 7 (1), pp. 37-51. Date of Electronic Publication: 2015 Jan 06.
    Typ publikacji:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Disease Outbreaks*
    Immunologic Memory*
    Ebolavirus/*immunology
    Hemorrhagic Fever, Ebola/*epidemiology
    Hemorrhagic Fever, Ebola/*immunology
    Antibodies, Viral/blood ; Cohort Studies ; Cross Reactions ; Cytokines/metabolism ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunity, Cellular ; Immunoglobulin G/blood ; Neutralization Tests ; Sudan ; Survivors ; Uganda/epidemiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-5 z 5

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