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Tytuł :
Heparin: A simplistic repurposing to prevent SARS-CoV-2 transmission in light of its in-vitro nanomolar efficacy.
Autorzy :
Gupta Y; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA.
Maciorowski D; Loyola University Chicago, Chicago, IL, USA.
Zak SE; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA, USA.
Kulkarni CV; School of Natural Sciences, University of Central Lancashire, Preston, UK.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Durvasula R; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA.
Fareed J; Department of Molecular Pharmacology & Neuroscience, Loyola University Chicago, Chicago, IL, USA.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA, USA.
Kempaiah P; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Apr 26; Vol. 183, pp. 203-212. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
Autorzy :
Rappazzo CG; Adimab, LLC, Lebanon, NH 03766, USA.
Tse LV; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kaku CI; Adimab, LLC, Lebanon, NH 03766, USA.
Wrapp D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Sakharkar M; Adimab, LLC, Lebanon, NH 03766, USA.
Huang D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Deveau LM; Adimab, LLC, Lebanon, NH 03766, USA.
Yockachonis TJ; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.
Battles MB; Adimab, LLC, Lebanon, NH 03766, USA.
O'Brien CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.
Brown ME; Adimab, LLC, Lebanon, NH 03766, USA.
Geoghegan JC; Adimab, LLC, Lebanon, NH 03766, USA.
Belk J; Adimab, LLC, Lebanon, NH 03766, USA.
Peng L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Yang L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Hou Y; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Scobey TD; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA.
Nemazee D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Voss JE; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Gunn BM; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA.
McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Baric RS; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. .; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Gralinski LE; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. .
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA. .; Adagio Therapeutics, Inc., Waltham, MA 02451, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 823-829. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Betacoronavirus/*immunology
Broadly Neutralizing Antibodies/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/metabolism ; Antibodies, Viral/genetics ; Antibodies, Viral/metabolism ; Antibody Affinity ; Binding Sites ; Binding Sites, Antibody ; Broadly Neutralizing Antibodies/genetics ; Broadly Neutralizing Antibodies/metabolism ; COVID-19/prevention & control ; COVID-19/therapy ; Cell Surface Display Techniques ; Directed Molecular Evolution ; Epitopes/immunology ; Humans ; Immunization, Passive ; Immunoglobulin Fc Fragments/immunology ; Mice, Inbred BALB C ; Protein Domains ; Protein Engineering ; Receptors, Coronavirus/metabolism ; SARS Virus/immunology ; Severe Acute Respiratory Syndrome/immunology ; Severe Acute Respiratory Syndrome/prevention & control ; Severe Acute Respiratory Syndrome/therapy ; Spike Glycoprotein, Coronavirus/metabolism
SCR Protocol :
COVID-19 serotherapy
Czasopismo naukowe
Tytuł :
Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays.
Autorzy :
Gupta Y; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Department of Medicine, Loyola University Medical Center, Chicago, IL 60153, USA.
Maciorowski D; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Loyola University Chicago, Chicago, IL, USA.
Zak SE; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA.
Jones KA; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Kathayat RS; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Azizi SA; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Mathur R; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA.
Pearce CM; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA.
Ilc DJ; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Loyola University Chicago, Chicago, IL, USA.
Husein H; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Loyola University Chicago, Chicago, IL, USA.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Bharti A; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, CA 92093, USA.
Rathi B; Department of Medicine, Loyola University Medical Center, Chicago, IL 60153, USA; Laboratory for Translational Chemistry and Drug Discovery, Hansraj College, University of Delhi, India.
Durvasula R; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Department of Medicine, Loyola University Medical Center, Chicago, IL 60153, USA.
Becker DP; Loyola University Chicago, Chicago, IL, USA.
Dickinson BC; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA.
Kempaiah P; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Department of Medicine, Loyola University Medical Center, Chicago, IL 60153, USA. Electronic address: .
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Źródło :
Methods (San Diego, Calif.) [Methods] 2021 Jan 14. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19.
Autorzy :
Rappazzo CG
Tse LV
Kaku CI
Wrapp D
Sakharkar M
Huang D
Deveau LM
Yockachonis TJ
Herbert AS
Battles MB
O'Brien CM
Brown ME
Geoghegan JC
Belk J
Peng L
Yang L
Scobey TD
Burton DR
Nemazee D
Dye JM
Voss JE
Gunn BM
McLellan JS
Baric RS
Gralinski LE
Walker LM
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Źródło :
BioRxiv : the preprint server for biology [bioRxiv] 2020 Nov 17. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Preprint
Tytuł :
A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition.
Autorzy :
Dieterle ME; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Haslwanter D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bortz RH 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Lasso G; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Vergnolle O; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Laudermilch E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Florez C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Chemistry and Life Science, United States Military Academy at West Point, West Point, NY 10996, USA.
Mengotto A; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Kimmel D; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Malonis RJ; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Georgiev G; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Quiroz J; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Barnhill J; Department of Chemistry and Life Science, United States Military Academy at West Point, West Point, NY 10996, USA.
Pirofski LA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Daily JP; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA. Electronic address: andrew.s..
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2020 Sep 09; Vol. 28 (3), pp. 486-496.e6. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus/*pathogenicity
Coronavirus Infections/*virology
Pneumonia, Viral/*virology
Spike Glycoprotein, Coronavirus/*physiology
Vesicular stomatitis Indiana virus/*physiology
Angiotensin-Converting Enzyme 2 ; Animals ; Antiviral Agents/pharmacology ; Betacoronavirus/genetics ; Betacoronavirus/physiology ; COVID-19 ; COVID-19 Vaccines ; Cell Line ; Chlorocebus aethiops ; Coronavirus Infections/drug therapy ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Drug Evaluation, Preclinical ; Host Microbial Interactions/drug effects ; Host Microbial Interactions/genetics ; Host Microbial Interactions/physiology ; Humans ; Mutation ; Neutralization Tests ; Pandemics/prevention & control ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/physiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Receptors, Virus/genetics ; Receptors, Virus/physiology ; Recombination, Genetic ; SARS-CoV-2 ; Serine Endopeptidases/physiology ; Spike Glycoprotein, Coronavirus/genetics ; Vero Cells ; Vesicular stomatitis Indiana virus/genetics ; Viral Vaccines/genetics ; Viral Vaccines/immunology ; Virus Internalization ; Virus Replication/genetics
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2.
Autorzy :
Chan KK; Orthogonal Biologics, Champaign, IL 61821, USA.
Dorosky D; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Sharma P; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA.
Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Kranz DM; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.
Procko E; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Sep 04; Vol. 369 (6508), pp. 1261-1265. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Engineering*
Betacoronavirus/*metabolism
Peptidyl-Dipeptidase A/*genetics
Peptidyl-Dipeptidase A/*metabolism
Receptors, Virus/*genetics
Receptors, Virus/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Amino Acid Substitution ; Angiotensin-Converting Enzyme 2 ; Binding Sites ; Binding, Competitive ; Cell Line ; Humans ; Models, Molecular ; Mutagenesis ; Mutation ; Peptidyl-Dipeptidase A/chemistry ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Receptors, Coronavirus ; Receptors, Virus/chemistry ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry
Czasopismo naukowe
Tytuł :
Broad neutralization of SARS-related viruses by human monoclonal antibodies.
Autorzy :
Wec AZ; Adimab LLC, Lebanon, NH 03766, USA.
Wrapp D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Maurer DP; Adimab LLC, Lebanon, NH 03766, USA.
Haslwanter D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Sakharkar M; Adimab LLC, Lebanon, NH 03766, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Dieterle ME; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Lilov A; Adimab LLC, Lebanon, NH 03766, USA.
Huang D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tse LV; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Hsieh CL; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Wang N; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Nett JH; Adimab LLC, Lebanon, NH 03766, USA.
Champney E; Adimab LLC, Lebanon, NH 03766, USA.
Burnina I; Adimab LLC, Lebanon, NH 03766, USA.
Brown M; Adimab LLC, Lebanon, NH 03766, USA.
Lin S; Adimab LLC, Lebanon, NH 03766, USA.
Sinclair M; Adimab LLC, Lebanon, NH 03766, USA.
Johnson C; Adimab LLC, Lebanon, NH 03766, USA.
Pudi S; Adimab LLC, Lebanon, NH 03766, USA.
Bortz R 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Laudermilch E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Florez C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
O'Brien CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Graham BS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Nemazee D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA.
Baric RS; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Voss JE; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Walker LM; Adimab LLC, Lebanon, NH 03766, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Aug 07; Vol. 369 (6504), pp. 731-736. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Betacoronavirus/*immunology
Broadly Neutralizing Antibodies/*immunology
SARS Virus/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Adult ; Aged ; Angiotensin-Converting Enzyme 2 ; Antibody Affinity ; B-Lymphocyte Subsets/immunology ; Binding Sites ; Cross Reactions ; Epitopes ; Female ; Humans ; Immunologic Memory ; Male ; Middle Aged ; Neutralization Tests ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Protein Domains ; Receptors, Coronavirus ; Receptors, Virus/chemistry ; Receptors, Virus/metabolism ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/immunology ; Somatic Hypermutation, Immunoglobulin ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition.
Autorzy :
Dieterle ME; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Haslwanter D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Bortz RH 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Lasso G; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Vergnolle O; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Laudermilch E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Florez C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.; Department of Chemistry and Life Science, United States Military Academy at West Point, West Point, NY 10996, USA.
Mengotto A; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Kimmel D; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Malonis RJ; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Georgiev G; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Quiroz J; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Barnhill J; Department of Chemistry and Life Science, United States Military Academy at West Point, West Point, NY 10996, USA.
Pirofski LA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Daily JP; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
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Źródło :
BioRxiv : the preprint server for biology [bioRxiv] 2020 May 20. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Preprint
Tytuł :
Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein.
Autorzy :
Wec AZ; Adimab LLC, Lebanon, NH 03766, USA.
Wrapp D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Maurer D; Adimab LLC, Lebanon, NH 03766, USA.
Haslwanter D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Sakharkar M; Adimab LLC, Lebanon, NH 03766, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Dieterle ME; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Lilov A; Adimab LLC, Lebanon, NH 03766, USA.
Huang D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tse LV; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Hsieh CL; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Wang N; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Nett JH; Adimab LLC, Lebanon, NH 03766, USA.
Champney E; Adimab LLC, Lebanon, NH 03766, USA.
Burnina I; Adimab LLC, Lebanon, NH 03766, USA.
Brown M; Adimab LLC, Lebanon, NH 03766, USA.
Lin S; Adimab LLC, Lebanon, NH 03766, USA.
Sinclair M; Adimab LLC, Lebanon, NH 03766, USA.
Johnson C; Adimab LLC, Lebanon, NH 03766, USA.
Pudi S; Adimab LLC, Lebanon, NH 03766, USA.
Bortz R 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Laudermilch E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Florez C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
O'Brien CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Graham BS; Adimab LLC, Lebanon, NH 03766, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard.; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Nemazee D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Burton DR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard.
Baric RS; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Voss JE; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Walker LM; Adimab LLC, Lebanon, NH 03766, USA.
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Źródło :
BioRxiv : the preprint server for biology [bioRxiv] 2020 May 16. Date of Electronic Publication: 2020 May 16.
Typ publikacji :
Preprint
Tytuł :
Development of an antibody cocktail for treatment of Sudan virus infection.
Autorzy :
Herbert AS; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Froude JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Ortiz RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Kuehne AI; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Dorosky DE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Zak SE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Josleyn NM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Musiychuk K; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Jones RM; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Green B; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Streatfield SJ; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Bohorova N; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Bohorov O; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Kim DH; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Pauly MH; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Velasco J; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Whaley KJ; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Stonier SW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Sampey D; BioFactura, Inc., Frederick, MD 21701.
Yusibov V; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 18; Vol. 117 (7), pp. 3768-3778. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Viral/*administration & dosage
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*drug therapy
Animals ; Antibodies, Monoclonal/administration & dosage ; Disease Models, Animal ; Ebolavirus/genetics ; Female ; Glycoproteins/immunology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunotherapy ; Macaca mulatta ; Male ; Mice ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Multiple viral proteins and immune response pathways act to generate robust long-term immunity in Sudan virus survivors.
Autorzy :
Sobarzo A; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. Electronic address: .
Stonier SW; US Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, MD 21702-5011, USA.
Radinsky O; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Gelkop S; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Kuehne AI; US Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, MD 21702-5011, USA.
Edri A; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Herbert AS; US Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, MD 21702-5011, USA.
Fedida-Metula S; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Lutwama JJ; Department of Arbovirology, Emerging and Re-Emerging Infection Uganda Virus Research Institute, Plot No: 51 -59, Nakiwogo Road, P.O.Box 49, Entebbe, Uganda.
Yavelsky V; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; Department of Arbovirology, Emerging and Re-Emerging Infection Uganda Virus Research Institute, Plot No: 51 -59, Nakiwogo Road, P.O.Box 49, Entebbe, Uganda.
Davis C; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Porgador A; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Dye JM; US Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, MD 21702-5011, USA. Electronic address: .
Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; Department of Arbovirology, Emerging and Re-Emerging Infection Uganda Virus Research Institute, Plot No: 51 -59, Nakiwogo Road, P.O.Box 49, Entebbe, Uganda.
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Źródło :
EBioMedicine [EBioMedicine] 2019 Aug; Vol. 46, pp. 215-226. Date of Electronic Publication: 2019 Jul 17.
Typ publikacji :
Journal Article
MeSH Terms :
Immunity*
Antigens, Viral/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Host-Pathogen Interactions/*immunology
Viral Proteins/*immunology
Adult ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Biomarkers ; Disease Outbreaks ; Female ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/metabolism ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunologic Memory ; Male ; Middle Aged ; Neutralization Tests ; Signal Transduction ; Survivors ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Structural basis of broad ebolavirus neutralization by a human survivor antibody.
Autorzy :
West BR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.; Adimab LLC, Lebanon, NH, USA.
Moyer CL; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Mapp Biopharmaceutical, San Diego, CA, USA.
Fusco ML; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
James RM; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Herbert AS; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Hui S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Goodwin E; Adimab LLC, Lebanon, NH, USA.
Howell KA; Integrated Biotherapeutics, Rockville, MD, USA.
Kailasan S; Integrated Biotherapeutics, Rockville, MD, USA.
Aman MJ; Integrated Biotherapeutics, Rockville, MD, USA.
Walker LM; Adimab LLC, Lebanon, NH, USA.
Dye JM; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Immunology and Microbiology, University of Texas Medical Branch, Galveston, TX, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA. .
Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. .; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2019 Mar; Vol. 26 (3), pp. 204-212. Date of Electronic Publication: 2019 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Viral Fusion Proteins/*immunology
Antibodies, Monoclonal/immunology ; Antibody Affinity/immunology ; Crystallography, X-Ray ; Humans ; Protein Structure, Tertiary ; Survivors
Czasopismo naukowe
Tytuł :
Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bornholdt ZA; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Goodwin E; Adimab, LLC, Lebanon, NH 03766, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Zhang Z; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Liu G; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Abelson DM; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Moyer CL; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
James RM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Bohorova N; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Bohorov O; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Kim DH; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Pauly MH; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Velasco J; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Bortz RH 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Whaley KJ; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Goldstein T; One Health Institute and Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Anthony SJ; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA. Electronic address: .
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2019 Jan 09; Vol. 25 (1), pp. 39-48.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animal Welfare ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/administration & dosage ; Antibodies, Viral/therapeutic use ; Antiviral Agents ; Disease Models, Animal ; Ebolavirus/pathogenicity ; Epitopes/immunology ; Female ; Filoviridae/immunology ; Guinea Pigs ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunotherapy ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Recombinant Proteins/immunology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates.
Autorzy :
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Mire CE; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Cross RW; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Abelson DM; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Geisbert JB; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
James RM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Rahim MN; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Borisevich V; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Banadyga L; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Gunn BM; The Ragon Institute, Cambridge, MA, USA.
Agans KN; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Goodwin E; Adimab LLC, Lebanon, NH, USA.
Tierney K; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Shestowsky WS; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Bohorov O; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Bohorova N; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Velasco J; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Ailor E; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Kim D; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Pauly MH; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Whaley KJ; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Alter G; The Ragon Institute, Cambridge, MA, USA.
Walker LM; Adimab LLC, Lebanon, NH, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA, USA. Electronic address: .
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada. Electronic address: .
Geisbert TW; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA. Electronic address: .
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2019 Jan 09; Vol. 25 (1), pp. 49-58.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Monoclonal/*therapeutic use
Antibodies, Viral/*immunology
Antibodies, Viral/*therapeutic use
Ebolavirus/*pathogenicity
Ferrets/*virology
Hemorrhagic Fever, Ebola/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animal Welfare ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/administration & dosage ; Cell Line ; Chlorocebus aethiops ; Disease Models, Animal ; Female ; Filoviridae/immunology ; Filoviridae Infections/immunology ; Filoviridae Infections/prevention & control ; Filoviridae Infections/virology ; Glycoproteins/immunology ; Guinea Pigs ; HEK293 Cells ; Hemorrhagic Fever, Ebola/virology ; Humans ; Killer Cells, Natural ; Macaca ; Macaca fascicularis ; Male ; Primates ; Survival Analysis ; Treatment Outcome ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection.
Autorzy :
Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: .
Schendel SL; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Fusco ML; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Gangavarapu K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Gunn BM; Ragon Institute, Cambridge, MA 02139, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Halfmann PJ; Division of Pathobiological Sciences, University of Wisconsin, Madison, WI 53706, USA.
Brannan JM; Division of Virology, United States Army Research Institute for Infectious Diseases, Ft. Detrick, MD 21702, USA.
Herbert AS; Division of Virology, United States Army Research Institute for Infectious Diseases, Ft. Detrick, MD 21702, USA.
Qiu X; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg R3E 3R2, Canada.
Wagh K; Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
He S; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg R3E 3R2, Canada.
Giorgi EE; Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Theiler J; Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Pommert KBJ; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Krause TB; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Turner HL; Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Murin CD; Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Pallesen J; Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Davidson E; Integral Molecular, Philadelphia, PA 19104, USA.
Ahmed R; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA.
Aman MJ; Integrated BioTherapeutics, Rockville, MD 20850, USA.
Bukreyev A; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.
Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Davis CW; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA.
Georgiou G; Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kyratsous CA; Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
Lai JR; Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Nykiforuk C; Emergent BioSolutions, Winnipeg, Manitoba, R3T 5Y3, Canada.
Pauly MH; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Rijal P; Human Immunology Unit, University of Oxford, Oxford OX3 9DS, UK.
Takada A; Research Center for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.
Townsend AR; Human Immunology Unit, University of Oxford, Oxford OX3 9DS, UK.
Volchkov V; INSERM CNRS, Université Lyon, Lyon, France.
Walker LM; Adimab, LLC. Lebanon, NH 03766, USA.
Wang CI; Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), Biopolis 138648, Singapore.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Doranz BJ; Integral Molecular, Philadelphia, PA 19104, USA.
Ward AB; Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Korber B; Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Kobinger GP; Département de Microbiologie-Infectiologie et d'Immunologie, Médecine, Université Laval Quebec, G1V 046 Canada. Electronic address: .
Andersen KG; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: .
Kawaoka Y; Division of Pathobiological Sciences, University of Wisconsin, Madison, WI 53706, USA. Electronic address: .
Alter G; Ragon Institute, Cambridge, MA 02139, USA. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
Dye JM; Division of Virology, United States Army Research Institute for Infectious Diseases, Ft. Detrick, MD 21702, USA. Electronic address: .
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Corporate Authors :
Viral Hemorrhagic Fever Immunotherapeutic Consortium
Źródło :
Cell [Cell] 2018 Aug 09; Vol. 174 (4), pp. 938-952.e13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Monoclonal/*isolation & purification
Ebolavirus/*immunology
Epitopes/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Membrane Glycoproteins/*immunology
Animals ; Antibodies, Monoclonal/administration & dosage ; Female ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/virology ; Immunization ; Mice ; Mice, Inbred BALB C ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus.
Autorzy :
Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Yu WH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Karim MM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Brannan JM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Herbert AS; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Halfmann PJ; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin, Madison, WI 53706, USA.
Fusco ML; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.
Schendel SL; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.
Gangavarapu K; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.
Krause T; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Qiu X; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
He S; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Das J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Suscovich TJ; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Lai J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Crowe JE Jr; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
Lauffenburger D; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kawaoka Y; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin, Madison, WI 53706, USA.
Kobinger GP; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Université Laval Quebec, Québec, QC G1V 0A6, Canada.
Andersen KG; Department of Immunology and Microbial Science, Scripps Translational Science Institute, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA. Electronic address: .
Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2018 Aug 08; Vol. 24 (2), pp. 221-233.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Immunoglobulin Fc Fragments/*immunology
Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Female ; Hemorrhagic Fever, Ebola/immunology ; Humans ; Killer Cells, Natural/immunology ; Mice ; Mice, Inbred BALB C ; Neutralization Tests ; RAW 264.7 Cells
Czasopismo naukowe

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