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Tytuł :
Ebola virus entry requires the cholesterol transporter Niemann-Pick C1.
Autorzy :
Carette JE; Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.
Raaben M
Wong AC
Herbert AS
Obernosterer G
Mulherkar N
Kuehne AI
Kranzusch PJ
Griffin AM
Ruthel G
Dal Cin P
Dye JM
Whelan SP
Chandran K
Brummelkamp TR
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Źródło :
Nature [Nature] 2011 Aug 24; Vol. 477 (7364), pp. 340-3. Date of Electronic Publication: 2011 Aug 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Virus Internalization*
Carrier Proteins/*metabolism
Cholesterol/*metabolism
Ebolavirus/*physiology
Membrane Glycoproteins/*metabolism
Animals ; Biological Transport ; Carrier Proteins/genetics ; Cell Line ; Endosomes/metabolism ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibroblasts/virology ; Genome, Human/genetics ; Glycoproteins/metabolism ; Haploidy ; Hemorrhagic Fever, Ebola/drug therapy ; Hemorrhagic Fever, Ebola/metabolism ; Host-Pathogen Interactions/genetics ; Humans ; Intracellular Signaling Peptides and Proteins ; Lysosomes/metabolism ; Marburg Virus Disease/drug therapy ; Marburg Virus Disease/metabolism ; Marburgvirus/physiology ; Membrane Fusion/genetics ; Membrane Fusion/physiology ; Membrane Glycoproteins/deficiency ; Membrane Glycoproteins/genetics ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/deficiency ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Mutation/genetics ; Niemann-Pick Diseases/pathology ; Niemann-Pick Diseases/virology ; Receptors, Virus/metabolism ; Vesicular Transport Proteins ; Viral Fusion Proteins/metabolism
Czasopismo naukowe
Tytuł :
Ebola virus entry requires the host-programmed recognition of an intracellular receptor.
Autorzy :
Miller EH; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Obernosterer G
Raaben M
Herbert AS
Deffieu MS
Krishnan A
Ndungo E
Sandesara RG
Carette JE
Kuehne AI
Ruthel G
Pfeffer SR
Dye JM
Whelan SP
Brummelkamp TR
Chandran K
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Źródło :
The EMBO journal [EMBO J] 2012 Apr 18; Vol. 31 (8), pp. 1947-60. Date of Electronic Publication: 2012 Mar 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Internalization*
Carrier Proteins/*metabolism
Ebolavirus/*physiology
Membrane Glycoproteins/*metabolism
Receptors, Virus/*metabolism
Viral Envelope Proteins/*metabolism
Animals ; Cell Line ; Humans ; Intracellular Signaling Peptides and Proteins ; Models, Biological ; Models, Molecular ; Protein Binding ; Viperidae ; Viral Envelope Proteins/chemistry
Czasopismo naukowe
Tytuł :
Venezuelan equine encephalitis virus replicon particle vaccine protects nonhuman primates from intramuscular and aerosol challenge with ebolavirus.
Autorzy :
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Kuehne AI
Barth JF
Ortiz RA
Nichols DK
Zak SE
Stonier SW
Muhammad MA
Bakken RR
Prugar LI
Olinger GG
Groebner JL
Lee JS
Pratt WD
Custer M
Kamrud KI
Smith JF
Hart MK
Dye JM
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Źródło :
Journal of virology [J Virol] 2013 May; Vol. 87 (9), pp. 4952-64. Date of Electronic Publication: 2013 Feb 13.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Replicon*
Ebolavirus/*immunology
Encephalitis Virus, Venezuelan Equine/*genetics
Hemorrhagic Fever, Ebola/*prevention & control
Viral Vaccines/*immunology
Animals ; Antibodies, Viral/immunology ; Ebolavirus/genetics ; Encephalitis Virus, Venezuelan Equine/physiology ; Genetic Vectors/genetics ; Genetic Vectors/physiology ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Macaca fascicularis ; Vaccination ; Viral Envelope Proteins/administration & dosage ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology ; Viral Vaccines/administration & dosage ; Viral Vaccines/genetics
Czasopismo naukowe
Tytuł :
Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.
Autorzy :
Clinton TR; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, 84112-5650.
Weinstock MT
Jacobsen MT
Szabo-Fresnais N
Pandya MJ
Whitby FG
Herbert AS
Prugar LI
McKinnon R
Hill CP
Welch BD
Dye JM
Eckert DM
Kay MS
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Źródło :
Protein science : a publication of the Protein Society [Protein Sci] 2015 Apr; Vol. 24 (4), pp. 446-63. Date of Electronic Publication: 2014 Oct 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ebolavirus/*chemistry
Viral Envelope Proteins/*chemistry
Viral Envelope Proteins/*metabolism
Amino Acid Sequence ; Drug Delivery Systems ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Sequence Alignment ; Viral Envelope Proteins/genetics
Czasopismo naukowe
Tytuł :
Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.
Autorzy :
Clinton, Tracy R.
Weinstock, Matthew T.
Jacobsen, Michael T.
Szabo‐Fresnais, Nicolas
Pandya, Maya J.
Whitby, Frank G.
Herbert, Andrew S.
Prugar, Laura I.
McKinnon, Rena
Hill, Christopher P.
Welch, Brett D.
Dye, John M.
Eckert, Debra M.
Kay, Michael S.
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Źródło :
Protein Science: A Publication of the Protein Society; Apr2015, Vol. 24 Issue 4, p446-463, 18p
Czasopismo naukowe
Tytuł :
Novel Small Molecule Entry Inhibitors of Ebola Virus.
Autorzy :
Basu A; Microbiotix, Inc, Worcester, Massachusetts.
Mills DM; Microbiotix, Inc, Worcester, Massachusetts.
Mitchell D; Texas Biomedical Research Institute, San Antonio.
Ndungo E; Albert Einstein College of Medicine, Bronx, New York.
Williams JD; Microbiotix, Inc, Worcester, Massachusetts.
Herbert AS; Army Medical Research Institute of Infectious Diseases, Frederick, Maryland.
Dye JM; Army Medical Research Institute of Infectious Diseases, Frederick, Maryland.
Moir DT; Microbiotix, Inc, Worcester, Massachusetts.
Chandran K; Albert Einstein College of Medicine, Bronx, New York.
Patterson JL; Texas Biomedical Research Institute, San Antonio.
Rong L; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago.
Bowlin TL; Microbiotix, Inc, Worcester, Massachusetts.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2015 Oct 01; Vol. 212 Suppl 2, pp. S425-34. Date of Electronic Publication: 2015 Jul 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antiviral Agents/*pharmacology
Ebolavirus/*drug effects
Hemorrhagic Fever, Ebola/*drug therapy
Hemorrhagic Fever, Ebola/*virology
Small Molecule Libraries/*pharmacology
Animals ; Carrier Proteins/metabolism ; Cell Line ; Chlorocebus aethiops ; Glycoproteins/metabolism ; HEK293 Cells ; Humans ; Intracellular Signaling Peptides and Proteins ; Membrane Glycoproteins/metabolism ; Protein Binding/drug effects ; Vero Cells ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle.
Autorzy :
Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Wu H; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
Hooper JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Kuehne AI; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Coyle EM; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Ortiz RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Fuentes S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Herbert AS; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Golding H; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Bakken RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Brannan JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Kwilas SA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Sullivan EJ; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
Luke TC; Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation, Silver Spring, Maryland, USA.
Smith G; Novavax Inc, Gaithersburg, Maryland, USA.
Glenn G; Novavax Inc, Gaithersburg, Maryland, USA.
Li W; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Ye L; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Yang C; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Compans RW; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Tripp RA; The University of Georgia, Athens, Georgia, 30602, USA.
Jiao JA; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
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Źródło :
Scientific reports [Sci Rep] 2016 Apr 25; Vol. 6, pp. 24897. Date of Electronic Publication: 2016 Apr 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Animals, Genetically Modified*
Cattle*
Antibodies, Viral/*blood
Antibodies, Viral/*therapeutic use
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animals ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunization, Passive ; Immunoglobulin G/blood ; Immunoglobulin G/therapeutic use ; Mice, Inbred BALB C ; Neutralization Tests ; Surface Plasmon Resonance ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors.
Autorzy :
Sobarzo A; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Stonier SW; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. .
Herbert AS; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. anderw.s.herbert..
Ochayon DE; Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Kuehne AI; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. .
Eskira Y; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Fedida-Metula S; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Tali N; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Lewis EC; Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Egesa M; Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe P.O. Box 49, Uganda. .; Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala P.O. Box 7072, Uganda. .
Cose S; Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe P.O. Box 49, Uganda. .; London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. .
Lutwama JJ; Department of Arbovirology, Emerging and Re-Emerging Infection Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda. .
Yavelsky V; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
Dye JM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, Frederick, MD 21701, USA. .
Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. .
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Źródło :
Viruses [Viruses] 2016 May 11; Vol. 8 (5). Date of Electronic Publication: 2016 May 11.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*blood
Antibodies, Viral/*blood
CD4-Positive T-Lymphocytes/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Cytokines/biosynthesis ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Humans ; Neutralization Tests ; Survivors ; Uganda
Czasopismo naukowe
Tytuł :
Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site.
Autorzy :
Howell KA; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Deparment of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Brannan JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Bryan C; Integral Molecular, Philadelphia, PA 19104, USA.
Davidson E; Integral Molecular, Philadelphia, PA 19104, USA.
Holtsberg FW; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Shulenin S; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Biggins JE; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Douglas R; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Enterlein SG; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Pallesen J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Deparment of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Kroeker A; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Deparment of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Vu H; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Keck ZY; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Foung SKH; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Doranz BJ; Integral Molecular, Philadelphia, PA 19104, USA.
Kobinger GP; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Deparment of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Aman MJ; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2016 May 17; Vol. 15 (7), pp. 1514-1526. Date of Electronic Publication: 2016 May 05.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Ebolavirus/*physiology
Epitopes/*immunology
Glycoproteins/*metabolism
Hemorrhagic Fever, Ebola/*immunology
Receptors, Virus/*metabolism
Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/ultrastructure ; Antibodies, Neutralizing ; Antibodies, Viral/chemistry ; Binding Sites ; Disease Models, Animal ; Female ; Glycoproteins/chemistry ; Glycoproteins/genetics ; Glycoproteins/ultrastructure ; Guinea Pigs ; HEK293 Cells ; Humans ; Kinetics ; Mice, Inbred BALB C ; Models, Molecular ; Mutation/genetics ; Negative Staining ; Neutralization Tests ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Howell KA; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Holtsberg FW; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Christin JR; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Shulenin S; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bharrhan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.
Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 10550, USA.
Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA. .; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Aman MJ; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. .
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. .
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2016 Oct 21; Vol. 354 (6310), pp. 350-354. Date of Electronic Publication: 2016 Sep 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Carrier Proteins/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Membrane Glycoproteins/*immunology
Receptors, Virus/*immunology
Viral Envelope Proteins/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Binding Sites/immunology ; Cell Line, Tumor ; Endosomes/virology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunotherapy/methods ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Inbred BALB C ; Virus Internalization
Czasopismo naukowe
Tytuł :
Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus.
Autorzy :
Howell KA; Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA.
Brannan JM; US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702-5011, USA.
Bryan C; Integral Molecular, Philadelphia, PA 19104, USA.
McNeal A; Integral Molecular, Philadelphia, PA 19104, USA.
Davidson E; Integral Molecular, Philadelphia, PA 19104, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Vu H; Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA.
Shulenin S; Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Kuehne A; US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702-5011, USA.
Herbert AS; US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702-5011, USA.
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Doranz BJ; Integral Molecular, Philadelphia, PA 19104, USA.
Holtsberg FW; Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702-5011, USA.
Aman MJ; Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2017 Apr 11; Vol. 19 (2), pp. 413-424.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Animals ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/therapeutic use ; Drug Synergism ; Ebolavirus/pathogenicity ; Hemorrhagic Fever, Ebola/therapy ; Hemorrhagic Fever, Ebola/virology ; Humans ; Mice
Czasopismo naukowe
Tytuł :
Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease.
Autorzy :
Kash JC; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Walters KA; Institute for Systems Biology, Seattle, WA 98109, USA.
Kindrachuk J; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA.
Baxter D; Institute for Systems Biology, Seattle, WA 98109, USA.
Scherler K; Institute for Systems Biology, Seattle, WA 98109, USA.
Janosko KB; Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Adams RD; Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
James RM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Stonier SW; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Memoli MJ; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Davey RT Jr; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Chertow DS; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA.
Taubenberger JK; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. .
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Źródło :
Science translational medicine [Sci Transl Med] 2017 Apr 12; Vol. 9 (385).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Intramural
MeSH Terms :
Ebolavirus/*pathogenicity
Hemorrhagic Fever, Ebola/*virology
Leukocytes/*metabolism
Disease Outbreaks ; Hemorrhagic Fever, Ebola/blood ; Humans ; Longitudinal Studies ; RNA, Viral/blood ; RNA, Viral/genetics ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail.
Autorzy :
Froude JW; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Herbert AS; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. andrew.s..
Pelat T; Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees (IRBA-CRSSA), La Tronche 38516, France. .
Miethe S; Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig 38106, Germany. .
Zak SE; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Brannan JM; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Bakken RR; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Steiner AR; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Yin G; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Hallam TJ; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Sato AK; Sutro Biopharma Inc., South San Francisco, CA 94080, USA. .
Hust M; Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig 38106, Germany. .
Thullier P; Unite de Biotechnologie des Anticorps, Institut de Recherche Biomedicale des Armees (IRBA-CRSSA), La Tronche 38516, France. .
Dye JM; US Army Medical Research Institute for Infectious Disease (USAMRIID), Fort Detrick, MD 21702, USA. .
Pokaż więcej
Źródło :
Viruses [Viruses] 2018 May 26; Vol. 10 (6). Date of Electronic Publication: 2018 May 26.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ebolavirus*
Post-Exposure Prophylaxis*
Antibodies, Viral/*pharmacology
Hemorrhagic Fever, Ebola/*therapy
Membrane Glycoproteins/*immunology
Vaccines, Virus-Like Particle/*immunology
Viral Matrix Proteins/*immunology
Animals ; Antibodies, Neutralizing/pharmacology ; Cell Surface Display Techniques ; Cross Reactions ; Female ; Macaca ; Male ; Mice ; Mice, Knockout ; Single-Chain Antibodies/pharmacology ; Vaccination
Czasopismo naukowe
Tytuł :
A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus.
Autorzy :
Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Yu WH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Karim MM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Brannan JM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Herbert AS; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Halfmann PJ; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin, Madison, WI 53706, USA.
Fusco ML; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.
Schendel SL; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.
Gangavarapu K; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.
Krause T; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Qiu X; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
He S; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Das J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Suscovich TJ; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Lai J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Crowe JE Jr; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
Lauffenburger D; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kawaoka Y; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin, Madison, WI 53706, USA.
Kobinger GP; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Université Laval Quebec, Québec, QC G1V 0A6, Canada.
Andersen KG; Department of Immunology and Microbial Science, Scripps Translational Science Institute, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA. Electronic address: .
Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2018 Aug 08; Vol. 24 (2), pp. 221-233.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Immunoglobulin Fc Fragments/*immunology
Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Female ; Hemorrhagic Fever, Ebola/immunology ; Humans ; Killer Cells, Natural/immunology ; Mice ; Mice, Inbred BALB C ; Neutralization Tests ; RAW 264.7 Cells
Czasopismo naukowe

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