Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle.
Autorzy:
Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA. Wu H; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America. Hooper JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA. Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA. Kuehne AI; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA. Coyle EM; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA. Ortiz RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA. Fuentes S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA. Herbert AS; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA. Golding H; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA. Bakken RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA. Brannan JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA. Kwilas SA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA. Sullivan EJ; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America. Luke TC; Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation, Silver Spring, Maryland, USA. Smith G; Novavax Inc, Gaithersburg, Maryland, USA. Glenn G; Novavax Inc, Gaithersburg, Maryland, USA. Li W; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA. Ye L; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA. Yang C; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA. Compans RW; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA. Tripp RA; The University of Georgia, Athens, Georgia, 30602, USA. Jiao JA; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
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Źródło:
Scientific reports [Sci Rep] 2016 Apr 25; Vol. 6, pp. 24897. Date of Electronic Publication: 2016 Apr 25.
A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
Autorzy:
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Howell KA; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. Holtsberg FW; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Christin JR; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Shulenin S; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Bharrhan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA. Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA. Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 10550, USA. Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA. .; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA. Aman MJ; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. . Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. . Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. . Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2016 Oct 21; Vol. 354 (6310), pp. 350-354. Date of Electronic Publication: 2016 Sep 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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