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Wyświetlanie 1-82 z 82
Tytuł :
Incorporation of membrane-bound, mammalian-derived immunomodulatory proteins into influenza whole virus vaccines boosts immunogenicity and protection against lethal challenge
Autorzy :
Roberts Paul C
Sundick Roy
Heffron Lynn
Herbert Andrew S
Pokaż więcej
Temat :
Infectious and parasitic diseases
RC109-216
Źródło :
Virology Journal, Vol 6, Iss 1, p 42 (2009)
Opis pliku :
electronic resource
Relacje :
http://www.virologyj.com/content/6/1/42; https://doaj.org/toc/1743-422X
Dostęp URL :
https://doaj.org/article/0daeb58cc1e845c2aeb29d57d3f8e6cd
Czasopismo naukowe
Tytuł :
Ebola virus entry requires the host-programmed recognition of an intracellular receptor.
Autorzy :
Miller EH; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Obernosterer G
Raaben M
Herbert AS
Deffieu MS
Krishnan A
Ndungo E
Sandesara RG
Carette JE
Kuehne AI
Ruthel G
Pfeffer SR
Dye JM
Whelan SP
Brummelkamp TR
Chandran K
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Źródło :
The EMBO journal [EMBO J] 2012 Apr 18; Vol. 31 (8), pp. 1947-60. Date of Electronic Publication: 2012 Mar 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Internalization*
Carrier Proteins/*metabolism
Ebolavirus/*physiology
Membrane Glycoproteins/*metabolism
Receptors, Virus/*metabolism
Viral Envelope Proteins/*metabolism
Animals ; Cell Line ; Humans ; Intracellular Signaling Peptides and Proteins ; Models, Biological ; Models, Molecular ; Protein Binding ; Viperidae ; Viral Envelope Proteins/chemistry
Czasopismo naukowe
Tytuł :
Venezuelan equine encephalitis virus replicon particle vaccine protects nonhuman primates from intramuscular and aerosol challenge with ebolavirus.
Autorzy :
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Kuehne AI
Barth JF
Ortiz RA
Nichols DK
Zak SE
Stonier SW
Muhammad MA
Bakken RR
Prugar LI
Olinger GG
Groebner JL
Lee JS
Pratt WD
Custer M
Kamrud KI
Smith JF
Hart MK
Dye JM
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Źródło :
Journal of virology [J Virol] 2013 May; Vol. 87 (9), pp. 4952-64. Date of Electronic Publication: 2013 Feb 13.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Replicon*
Ebolavirus/*immunology
Encephalitis Virus, Venezuelan Equine/*genetics
Hemorrhagic Fever, Ebola/*prevention & control
Viral Vaccines/*immunology
Animals ; Antibodies, Viral/immunology ; Ebolavirus/genetics ; Encephalitis Virus, Venezuelan Equine/physiology ; Genetic Vectors/genetics ; Genetic Vectors/physiology ; Hemorrhagic Fever, Ebola/immunology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Macaca fascicularis ; Vaccination ; Viral Envelope Proteins/administration & dosage ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology ; Viral Vaccines/administration & dosage ; Viral Vaccines/genetics
Czasopismo naukowe
Tytuł :
Virus entry. Lassa virus entry requires a trigger-induced receptor switch.
Autorzy :
Jae LT; Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.
Raaben M; Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA.
Wirchnianski AS; U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA.
Soh TK; Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Stubbs SH; Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Janssen H; Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.
Damme M; Biochemisches Institut, Christian Albrechts-Universität Kiel, 24118 Kiel, Germany.
Saftig P; Biochemisches Institut, Christian Albrechts-Universität Kiel, 24118 Kiel, Germany.
Whelan SP; Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. .
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA. .
Brummelkamp TR; Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. Cancer Genomics Center (CGC.nl), Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands. .
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Źródło :
Science (New York, N.Y.) [Science] 2014 Jun 27; Vol. 344 (6191), pp. 1506-10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Virus Internalization*
Lassa virus/*physiology
Lysosomal-Associated Membrane Protein 1/*metabolism
Receptors, Virus/*metabolism
Viral Envelope Proteins/*metabolism
Amino Acid Sequence ; Animals ; Cell Line ; Cell Membrane/metabolism ; Cell Membrane/virology ; Cells, Cultured ; Chickens ; Dystroglycans/genetics ; Dystroglycans/metabolism ; Glycosylation ; Humans ; Hydrogen-Ion Concentration ; Lassa Fever/virology ; Lysosomal-Associated Membrane Protein 1/chemistry ; Lysosomes/metabolism ; Lysosomes/virology ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Protein Binding ; Sialyltransferases/metabolism
Czasopismo naukowe
Tytuł :
Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.
Autorzy :
Clinton TR; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, 84112-5650.
Weinstock MT
Jacobsen MT
Szabo-Fresnais N
Pandya MJ
Whitby FG
Herbert AS
Prugar LI
McKinnon R
Hill CP
Welch BD
Dye JM
Eckert DM
Kay MS
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Źródło :
Protein science : a publication of the Protein Society [Protein Sci] 2015 Apr; Vol. 24 (4), pp. 446-63. Date of Electronic Publication: 2014 Oct 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Ebolavirus/*chemistry
Viral Envelope Proteins/*chemistry
Viral Envelope Proteins/*metabolism
Amino Acid Sequence ; Drug Delivery Systems ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Sequence Alignment ; Viral Envelope Proteins/genetics
Czasopismo naukowe
Tytuł :
Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.
Autorzy :
Clinton, Tracy R.
Weinstock, Matthew T.
Jacobsen, Michael T.
Szabo‐Fresnais, Nicolas
Pandya, Maya J.
Whitby, Frank G.
Herbert, Andrew S.
Prugar, Laura I.
McKinnon, Rena
Hill, Christopher P.
Welch, Brett D.
Dye, John M.
Eckert, Debra M.
Kay, Michael S.
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Źródło :
Protein Science: A Publication of the Protein Society; Apr2015, Vol. 24 Issue 4, p446-463, 18p
Czasopismo naukowe
Tytuł :
Novel Small Molecule Entry Inhibitors of Ebola Virus.
Autorzy :
Basu A; Microbiotix, Inc, Worcester, Massachusetts.
Mills DM; Microbiotix, Inc, Worcester, Massachusetts.
Mitchell D; Texas Biomedical Research Institute, San Antonio.
Ndungo E; Albert Einstein College of Medicine, Bronx, New York.
Williams JD; Microbiotix, Inc, Worcester, Massachusetts.
Herbert AS; Army Medical Research Institute of Infectious Diseases, Frederick, Maryland.
Dye JM; Army Medical Research Institute of Infectious Diseases, Frederick, Maryland.
Moir DT; Microbiotix, Inc, Worcester, Massachusetts.
Chandran K; Albert Einstein College of Medicine, Bronx, New York.
Patterson JL; Texas Biomedical Research Institute, San Antonio.
Rong L; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago.
Bowlin TL; Microbiotix, Inc, Worcester, Massachusetts.
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2015 Oct 01; Vol. 212 Suppl 2, pp. S425-34. Date of Electronic Publication: 2015 Jul 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antiviral Agents/*pharmacology
Ebolavirus/*drug effects
Hemorrhagic Fever, Ebola/*drug therapy
Hemorrhagic Fever, Ebola/*virology
Small Molecule Libraries/*pharmacology
Animals ; Carrier Proteins/metabolism ; Cell Line ; Chlorocebus aethiops ; Glycoproteins/metabolism ; HEK293 Cells ; Humans ; Intracellular Signaling Peptides and Proteins ; Membrane Glycoproteins/metabolism ; Protein Binding/drug effects ; Vero Cells ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses.
Autorzy :
Holtsberg FW; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Shulenin S; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Vu H; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Howell KA; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Patel SJ; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Gunn B; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, Massachusetts, USA.
Karim M; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, Massachusetts, USA.
Lai JR; Albert Einstein College of Medicine, New York, New York, USA.
Frei JC; Albert Einstein College of Medicine, New York, New York, USA.
Nyakatura EK; Albert Einstein College of Medicine, New York, New York, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, California, USA.
Douglas R; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Fusco ML; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Froude JW; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Wirchnianski AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Lear-Rooney CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Alter G; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Boston, Massachusetts, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Glass PJ; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Warfield KL; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Aman MJ; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA .
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Źródło :
Journal of virology [J Virol] 2015 Oct 14; Vol. 90 (1), pp. 266-78. Date of Electronic Publication: 2015 Oct 14 (Print Publication: 2016).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunization, Passive*
Antibodies, Monoclonal/*immunology
Antibodies, Monoclonal/*isolation & purification
Antibodies, Viral/*immunology
Antibodies, Viral/*isolation & purification
Filoviridae/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/administration & dosage ; Cross Protection ; Disease Models, Animal ; Epitopes/immunology ; Female ; Mice, Inbred BALB C ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein.
Autorzy :
Keck ZY; Department of Pathology, Stanford University, Stanford, California, USA.
Enterlein SG; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Howell KA; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Vu H; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Shulenin S; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Warfield KL; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Froude JW; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Araghi N; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Douglas R; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Biggins J; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Lear-Rooney CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Wirchnianski AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Lau P; Department of Pathology, Stanford University, Stanford, California, USA.
Wang Y; Department of Pathology, Stanford University, Stanford, California, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Glass PJ; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
Holtsberg FW; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA.
Foung SK; Department of Pathology, Stanford University, Stanford, California, USA.
Aman MJ; Integrated BioTherapeutics, Inc., Gaithersburg, Maryland, USA .
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Źródło :
Journal of virology [J Virol] 2015 Oct 14; Vol. 90 (1), pp. 279-91. Date of Electronic Publication: 2015 Oct 14 (Print Publication: 2016).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Epitopes/*immunology
Filoviridae/*immunology
Glycoproteins/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Viral Proteins/*immunology
Animals ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/isolation & purification ; Antibodies, Viral/therapeutic use ; Cross Reactions ; Disease Models, Animal ; Female ; Immunization, Passive ; Macaca ; Mice, Inbred BALB C ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.
Autorzy :
Melinda Ng
Ndungo, Esther
Kaczmarek, Maria E.
Herbert, Andrew S.
Binger, Tabea
Kuehne, Ana I.
Jangra, Rohit K.
Hawkins, John A.
Gifford, Robert J.
Biswas, Rohan
Demogines, Ann
James, Rebekah M.
Meng Yu
Brummelkamp, Thijn R.
Drosten, Christian
Lin-Fa Wang
Kuhn, Jens H.
Müller, Marcel A.
Dye, John M.
Sawyer, Sara L.
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Źródło :
eLife. Dec2015, p1-22. 22p. 7 Color Photographs.
Czasopismo naukowe
Tytuł :
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.
Autorzy :
Ng M; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
Ndungo E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
Kaczmarek ME; Department of Integrative Biology, University of Texas at Austin, Austin, United States.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States.
Binger T; Institute of Virology, University of Bonn Medical Center, Bonn, Germany.
Kuehne AI; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
Hawkins JA; Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, United States.
Gifford RJ; University of Glasgow MRC Virology Unit, Glasgow, United Kingdom.
Biswas R; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
Demogines A; Department of Molecular Biosciences, University of Texas at Austin, Austin, United States.
James RM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States.
Yu M; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, , Singapore.
Brummelkamp TR; Netherlands Cancer Institute, Plesmanlaan, The Netherlands.
Drosten C; Institute of Virology, University of Bonn Medical Center, Bonn, Germany.; German Centre for Infectious Diseases Research, Bonn, Germany.
Wang LF; Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, , Singapore.
Kuhn JH; Integrated Research Facility at Fort Detrick, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, United States.
Müller MA; Institute of Virology, University of Bonn Medical Center, Bonn, Germany.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, United States.
Sawyer SL; Department of Molecular Biosciences, University of Texas at Austin, Austin, United States.; BioFrontiers Institute, University of Colorado Boulder, Boulder, United States.; Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, United States.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States.
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Źródło :
ELife [Elife] 2015 Dec 23; Vol. 4. Date of Electronic Publication: 2015 Dec 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Host Specificity*
Virus Attachment*
Filoviridae/*physiology
Membrane Glycoproteins/*metabolism
Receptors, Virus/*metabolism
Animals ; Cell Line ; Chiroptera
Czasopismo naukowe
Tytuł :
Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle.
Autorzy :
Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Wu H; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
Hooper JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Khurana S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Kuehne AI; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Coyle EM; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Ortiz RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Fuentes S; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Herbert AS; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Golding H; Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, Maryland, USA.
Bakken RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Brannan JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Kwilas SA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.
Sullivan EJ; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
Luke TC; Viral and Rickettsial Diseases Department, Navy Medical Research Center, The Henry Jackson Foundation, Silver Spring, Maryland, USA.
Smith G; Novavax Inc, Gaithersburg, Maryland, USA.
Glenn G; Novavax Inc, Gaithersburg, Maryland, USA.
Li W; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Ye L; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Yang C; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Compans RW; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, 30322, USA.
Tripp RA; The University of Georgia, Athens, Georgia, 30602, USA.
Jiao JA; SAB Biotherapeutics, Sioux Falls, South Dakota, United States of America.
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Źródło :
Scientific reports [Sci Rep] 2016 Apr 25; Vol. 6, pp. 24897. Date of Electronic Publication: 2016 Apr 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Animals, Genetically Modified*
Cattle*
Antibodies, Viral/*blood
Antibodies, Viral/*therapeutic use
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animals ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunization, Passive ; Immunoglobulin G/blood ; Immunoglobulin G/therapeutic use ; Mice, Inbred BALB C ; Neutralization Tests ; Surface Plasmon Resonance ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors.
Autorzy :
Sobarzo, Ariel
Stonier, Spencer W.
Herbert, Andrew S.
Ochayon, David E.
Kuehne, Ana I.
Eskira, Yael
Fedida-Metula, Shlomit
Tali, Neta
Lewis, Eli C.
Egesa, Moses
Cose, Stephen
Lutwama, Julius Julian
Yavelsky, Victoria
Dye, John M.
Lobel, Leslie
Pokaż więcej
Temat :
cellular immunity
Microbiology
neutralizing antibodies
QR1-502
memory immunity
Ebola survivors
Article
Źródło :
Viruses, Vol 8, Iss 5, p 133 (2016)
Opis pliku :
application/pdf
Tytuł :
A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Howell KA; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Holtsberg FW; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Christin JR; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Shulenin S; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bharrhan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Bornholdt ZA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.
Flyak AI; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA.
Saphire EO; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 10550, USA.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 10550, USA.
Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN 37235, USA. .; Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.; Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA.
Aman MJ; Integrated Biotherapeutics Inc., Gaithersburg, MD 20878, USA. .
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. .
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2016 Oct 21; Vol. 354 (6310), pp. 350-354. Date of Electronic Publication: 2016 Sep 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Carrier Proteins/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Membrane Glycoproteins/*immunology
Receptors, Virus/*immunology
Viral Envelope Proteins/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Binding Sites/immunology ; Cell Line, Tumor ; Endosomes/virology ; Hemorrhagic Fever, Ebola/therapy ; Humans ; Immunotherapy/methods ; Intracellular Signaling Peptides and Proteins ; Mice ; Mice, Inbred BALB C ; Virus Internalization
Czasopismo naukowe
Tytuł :
Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease.
Autorzy :
Kash JC; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Walters KA; Institute for Systems Biology, Seattle, WA 98109, USA.
Kindrachuk J; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA.
Baxter D; Institute for Systems Biology, Seattle, WA 98109, USA.
Scherler K; Institute for Systems Biology, Seattle, WA 98109, USA.
Janosko KB; Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Adams RD; Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
James RM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Stonier SW; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Memoli MJ; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Davey RT Jr; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Chertow DS; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA.
Taubenberger JK; Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. .
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Źródło :
Science translational medicine [Sci Transl Med] 2017 Apr 12; Vol. 9 (385).
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Intramural
MeSH Terms :
Ebolavirus/*pathogenicity
Hemorrhagic Fever, Ebola/*virology
Leukocytes/*metabolism
Disease Outbreaks ; Hemorrhagic Fever, Ebola/blood ; Humans ; Longitudinal Studies ; RNA, Viral/blood ; RNA, Viral/genetics ; Virus Replication/physiology
Czasopismo naukowe
Tytuł :
Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Murin CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Abelson DM; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
James RM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
de La Vega MA; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Goodwin E; Adimab, LLC, Lebanon, NH 03766, USA.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
Bornholdt ZA; Mapp Biopharmaceutical, San Diego, CA 92121, USA. Electronic address: .
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Źródło :
Cell [Cell] 2017 May 18; Vol. 169 (5), pp. 878-890.e15.
Typ publikacji :
Journal Article
MeSH Terms :
Survivors*
Antibodies, Neutralizing/*isolation & purification
Antibodies, Viral/*isolation & purification
Ebola Vaccines/*immunology
Hemorrhagic Fever, Ebola/*immunology
Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/chemistry ; Antibodies, Viral/immunology ; Chlorocebus aethiops ; Cross Reactions ; Ebolavirus/classification ; Ebolavirus/immunology ; Female ; Ferrets ; Hemorrhagic Fever, Ebola/virology ; Humans ; Kinetics ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Sequence Alignment ; Vero Cells
Czasopismo naukowe
Tytuł :
[Accepted Manuscript] Marburg virus survivor immune responses are Th1 skewed with limited neutralizing antibody responses.
Autorzy :
Stonier, Spencer W.
James, Rebekah M.
Egesa, Moses
Cose, Stephen
Dye, John M.
Herbert, Andrew S.
Kuehne, Ana I.
Sobarzo, Ariel
Habibulin, Polina
Dahan, Chen V. Abramovitch
Lutwama, Julius Julian
Lobel, Leslie
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Temat :
Brief Definitive Report
humanities
human activities
social sciences
Research Articles
Źródło :
The Journal of Experimental Medicine
Opis pliku :
application/pdf
Tytuł :
Vesicular Stomatitis Virus Pseudotyped with Ebola Virus Glycoprotein Serves as a Protective, Noninfectious Vaccine against Ebola Virus Challenge in Mice.
Autorzy :
Lennemann NJ; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Brouillette R; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Rhein B; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Bakken RA; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Perschbacher KJ; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Cooney AL; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Miller-Hunt CL; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Ten Eyck P; Iowa Center for Clinical and Translational Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Biggins J; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Olinger G; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
Maury W; Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA .
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Źródło :
Journal of virology [J Virol] 2017 Aug 10; Vol. 91 (17). Date of Electronic Publication: 2017 Aug 10 (Print Publication: 2017).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Vesicular Stomatitis Virus Pseudotyped with Ebola Virus Glycoprotein Serves as a Protective, Noninfectious Vaccine against Ebola Virus Challenge in Mice
Autorzy :
Lennemann, Nicholas J.
Herbert, Andrew S.
Brouillette, Rachel
Rhein, Bethany
Bakken, Russell A.
Perschbacher, Katherine J.
Cooney, Ashley L.
Miller-Hunt, Catherine L.
Ten Eyck, Patrick
Biggins, Julia
Olinger, Gene
Dye, John M.
Maury, Wendy
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Temat :
Vaccines and Antiviral Agents
Tytuł :
NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.
Autorzy :
Raaben M; Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Jae LT; Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Virology Division, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Virology Division, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA.
Stubbs SH; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
Chou YY; Department of Cell Biology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Blomen VA; Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Kirchhausen T; Department of Cell Biology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Virology Division, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA.
Brummelkamp TR; Division of Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; CGC.nl; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 14 Vienna, Austria. Electronic address: .
Whelan SP; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2017 Nov 08; Vol. 22 (5), pp. 688-696.e5.
Typ publikacji :
Journal Article
MeSH Terms :
Virus Internalization*
Lujo virus/*physiology
Neuropilin-2/*metabolism
Tetraspanin 30/*metabolism
Viral Fusion Proteins/*metabolism
Viral Proteins/*metabolism
Carrier Proteins ; Cell Line ; Host-Pathogen Interactions/physiology ; Human Umbilical Vein Endothelial Cells ; Humans ; Lujo virus/genetics ; Lujo virus/pathogenicity ; Protein Interaction Domains and Motifs ; Receptors, Cell Surface/metabolism ; Receptors, Transferrin ; Viral Fusion Proteins/genetics ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus.
Autorzy :
Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Yu WH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Karim MM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Brannan JM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Herbert AS; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Halfmann PJ; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin, Madison, WI 53706, USA.
Fusco ML; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.
Schendel SL; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.
Gangavarapu K; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.
Krause T; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Qiu X; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
He S; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Das J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Suscovich TJ; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Lai J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Crowe JE Jr; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA.
Lauffenburger D; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Kawaoka Y; Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin, Madison, WI 53706, USA.
Kobinger GP; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Université Laval Quebec, Québec, QC G1V 0A6, Canada.
Andersen KG; Department of Immunology and Microbial Science, Scripps Translational Science Institute, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA. Electronic address: .
Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2018 Aug 08; Vol. 24 (2), pp. 221-233.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Immunoglobulin Fc Fragments/*immunology
Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Female ; Hemorrhagic Fever, Ebola/immunology ; Humans ; Killer Cells, Natural/immunology ; Mice ; Mice, Inbred BALB C ; Neutralization Tests ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Protocadherin-1 is essential for cell entry by New World hantaviruses.
Autorzy :
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Li R; Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA.
Jae LT; Oncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.
Kleinfelter LM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Slough MM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Barker SL; Donnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Guardado-Calvo P; Institut Pasteur, Structural Virology Unit and CNRS UMR3569, Paris, France.
Román-Sosa G; Institut Pasteur, Structural Virology Unit and CNRS UMR3569, Paris, France.
Dieterle ME; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Kuehne AI; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Muena NA; Fundación Ciencia & Vida, Laboratorio de Virología Molecular, Santiago, Chile.
Wirchnianski AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.; Department of Microbiology and Immunology and Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
Nyakatura EK; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Ng M; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Pan J; Donnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Bharrhan S; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.; Adimab LLC, Lebanon, NH, USA.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
Sidhu SS; Donnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Tischler ND; Fundación Ciencia & Vida, Laboratorio de Virología Molecular, Santiago, Chile.
Rey FA; Institut Pasteur, Structural Virology Unit and CNRS UMR3569, Paris, France.
Moffat J; Donnelly Centre and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Canadian Institute for Advanced Research, Toronto, Ontario, Canada.
Brummelkamp TR; Oncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands. .; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. .; Cancer GenomiCs.nl (CGC.nl), Amsterdam, The Netherlands. .
Wang Z; Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT, USA. .
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA. .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA. .
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Źródło :
Nature [Nature] 2018 Nov; Vol. 563 (7732), pp. 559-563. Date of Electronic Publication: 2018 Nov 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Internalization*
Cadherins/*metabolism
Hantavirus/*physiology
Animals ; Cadherins/chemistry ; Cadherins/deficiency ; Cadherins/genetics ; Endothelial Cells/virology ; Female ; Hantavirus/pathogenicity ; Hantavirus Pulmonary Syndrome/virology ; Haploidy ; Host-Pathogen Interactions/genetics ; Humans ; Lung/cytology ; Male ; Mesocricetus/virology ; Protein Domains ; Sin Nombre virus/pathogenicity ; Sin Nombre virus/physiology
Czasopismo naukowe
Tytuł :
Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection.
Autorzy :
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bornholdt ZA; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Goodwin E; Adimab, LLC, Lebanon, NH 03766, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Gunn BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Zhang Z; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Liu G; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.
Abelson DM; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Moyer CL; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
James RM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Bohorova N; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Bohorov O; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Kim DH; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Pauly MH; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Velasco J; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Bortz RH 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Whaley KJ; Mapp Biopharmaceutical, San Diego, CA 92121, USA.
Goldstein T; One Health Institute and Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Anthony SJ; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Zeitlin L; Mapp Biopharmaceutical, San Diego, CA 92121, USA. Electronic address: .
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2019 Jan 09; Vol. 25 (1), pp. 39-48.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animal Welfare ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/administration & dosage ; Antibodies, Viral/therapeutic use ; Antiviral Agents ; Disease Models, Animal ; Ebolavirus/pathogenicity ; Epitopes/immunology ; Female ; Filoviridae/immunology ; Guinea Pigs ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunotherapy ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Recombinant Proteins/immunology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates.
Autorzy :
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Mire CE; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
He S; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Cross RW; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Abelson DM; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Geisbert JB; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
James RM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.
Rahim MN; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
Zhu W; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Borisevich V; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Banadyga L; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Gunn BM; The Ragon Institute, Cambridge, MA, USA.
Agans KN; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Goodwin E; Adimab LLC, Lebanon, NH, USA.
Tierney K; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Shestowsky WS; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Bohorov O; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Bohorova N; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Velasco J; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Ailor E; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Kim D; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Pauly MH; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Whaley KJ; Mapp Biopharmaceutical, Inc., San Diego, CA, USA.
Alter G; The Ragon Institute, Cambridge, MA, USA.
Walker LM; Adimab LLC, Lebanon, NH, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA, USA. Electronic address: .
Qiu X; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada. Electronic address: .
Geisbert TW; Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, TX, USA. Electronic address: .
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2019 Jan 09; Vol. 25 (1), pp. 49-58.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Monoclonal/*therapeutic use
Antibodies, Viral/*immunology
Antibodies, Viral/*therapeutic use
Ebolavirus/*pathogenicity
Ferrets/*virology
Hemorrhagic Fever, Ebola/*immunology
Hemorrhagic Fever, Ebola/*prevention & control
Animal Welfare ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/administration & dosage ; Cell Line ; Chlorocebus aethiops ; Disease Models, Animal ; Female ; Filoviridae/immunology ; Filoviridae Infections/immunology ; Filoviridae Infections/prevention & control ; Filoviridae Infections/virology ; Glycoproteins/immunology ; Guinea Pigs ; HEK293 Cells ; Hemorrhagic Fever, Ebola/virology ; Humans ; Killer Cells, Natural ; Macaca ; Macaca fascicularis ; Male ; Primates ; Survival Analysis ; Treatment Outcome ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Structural basis of broad ebolavirus neutralization by a human survivor antibody.
Autorzy :
West BR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.; Adimab LLC, Lebanon, NH, USA.
Moyer CL; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.; Mapp Biopharmaceutical, San Diego, CA, USA.
Fusco ML; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Ilinykh PA; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Huang K; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
James RM; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Herbert AS; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Hui S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Goodwin E; Adimab LLC, Lebanon, NH, USA.
Howell KA; Integrated Biotherapeutics, Rockville, MD, USA.
Kailasan S; Integrated Biotherapeutics, Rockville, MD, USA.
Aman MJ; Integrated Biotherapeutics, Rockville, MD, USA.
Walker LM; Adimab LLC, Lebanon, NH, USA.
Dye JM; Division of Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Bukreyev A; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA.; Department of Immunology and Microbiology, University of Texas Medical Branch, Galveston, TX, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA. .
Saphire EO; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. .; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. .
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Źródło :
Nature structural & molecular biology [Nat Struct Mol Biol] 2019 Mar; Vol. 26 (3), pp. 204-212. Date of Electronic Publication: 2019 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
Ebolavirus/*immunology
Viral Fusion Proteins/*immunology
Antibodies, Monoclonal/immunology ; Antibody Affinity/immunology ; Crystallography, X-Ray ; Humans ; Protein Structure, Tertiary ; Survivors
Czasopismo naukowe
Tytuł :
Development of an antibody cocktail for treatment of Sudan virus infection.
Autorzy :
Herbert AS; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Froude JW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Ortiz RA; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Kuehne AI; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Dorosky DE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Bakken RR; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.
Zak SE; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Josleyn NM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Musiychuk K; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Jones RM; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Green B; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Streatfield SJ; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Wec AZ; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Bohorova N; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Bohorov O; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Kim DH; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Pauly MH; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Velasco J; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Whaley KJ; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Stonier SW; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702.; The Geneva Foundation, Tacoma, WA 98402.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Sampey D; BioFactura, Inc., Frederick, MD 21701.
Yusibov V; Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711.
Dye JM; Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 18; Vol. 117 (7), pp. 3768-3778. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Viral/*administration & dosage
Ebolavirus/*immunology
Hemorrhagic Fever, Ebola/*drug therapy
Animals ; Antibodies, Monoclonal/administration & dosage ; Disease Models, Animal ; Ebolavirus/genetics ; Female ; Glycoproteins/immunology ; Hemorrhagic Fever, Ebola/virology ; Humans ; Immunotherapy ; Macaca mulatta ; Male ; Mice ; Viral Proteins/immunology
Czasopismo naukowe
Tytuł :
Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein.
Autorzy :
Wec AZ; Adimab LLC, Lebanon, NH 03766, USA.
Wrapp D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Maurer D; Adimab LLC, Lebanon, NH 03766, USA.
Haslwanter D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Sakharkar M; Adimab LLC, Lebanon, NH 03766, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Dieterle ME; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Lilov A; Adimab LLC, Lebanon, NH 03766, USA.
Huang D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tse LV; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Hsieh CL; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Wang N; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Nett JH; Adimab LLC, Lebanon, NH 03766, USA.
Champney E; Adimab LLC, Lebanon, NH 03766, USA.
Burnina I; Adimab LLC, Lebanon, NH 03766, USA.
Brown M; Adimab LLC, Lebanon, NH 03766, USA.
Lin S; Adimab LLC, Lebanon, NH 03766, USA.
Sinclair M; Adimab LLC, Lebanon, NH 03766, USA.
Johnson C; Adimab LLC, Lebanon, NH 03766, USA.
Pudi S; Adimab LLC, Lebanon, NH 03766, USA.
Bortz R 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Laudermilch E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Florez C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
O'Brien CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Graham BS; Adimab LLC, Lebanon, NH 03766, USA.; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard.; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Nemazee D; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Burton DR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard.
Baric RS; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Voss JE; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Walker LM; Adimab LLC, Lebanon, NH 03766, USA.
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Źródło :
BioRxiv : the preprint server for biology [bioRxiv] 2020 May 16. Date of Electronic Publication: 2020 May 16.
Typ publikacji :
Preprint
Tytuł :
A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition.
Autorzy :
Dieterle ME; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Haslwanter D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Bortz RH 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Lasso G; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Vergnolle O; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Laudermilch E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Florez C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.; Department of Chemistry and Life Science, United States Military Academy at West Point, West Point, NY 10996, USA.
Mengotto A; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Kimmel D; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Malonis RJ; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Georgiev G; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Quiroz J; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Barnhill J; Department of Chemistry and Life Science, United States Military Academy at West Point, West Point, NY 10996, USA.
Pirofski LA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Daily JP; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY 10461, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10461, USA.
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Źródło :
BioRxiv : the preprint server for biology [bioRxiv] 2020 May 20. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Preprint
Tytuł :
Broad neutralization of SARS-related viruses by human monoclonal antibodies.
Autorzy :
Wec AZ; Adimab LLC, Lebanon, NH 03766, USA.
Wrapp D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Maurer DP; Adimab LLC, Lebanon, NH 03766, USA.
Haslwanter D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Sakharkar M; Adimab LLC, Lebanon, NH 03766, USA.
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Dieterle ME; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Lilov A; Adimab LLC, Lebanon, NH 03766, USA.
Huang D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tse LV; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Hsieh CL; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Wang N; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Nett JH; Adimab LLC, Lebanon, NH 03766, USA.
Champney E; Adimab LLC, Lebanon, NH 03766, USA.
Burnina I; Adimab LLC, Lebanon, NH 03766, USA.
Brown M; Adimab LLC, Lebanon, NH 03766, USA.
Lin S; Adimab LLC, Lebanon, NH 03766, USA.
Sinclair M; Adimab LLC, Lebanon, NH 03766, USA.
Johnson C; Adimab LLC, Lebanon, NH 03766, USA.
Pudi S; Adimab LLC, Lebanon, NH 03766, USA.
Bortz R 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Laudermilch E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Florez C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
O'Brien CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Graham BS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Nemazee D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA.
Baric RS; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Voss JE; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY 10462, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Walker LM; Adimab LLC, Lebanon, NH 03766, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Aug 07; Vol. 369 (6504), pp. 731-736. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Betacoronavirus/*immunology
Broadly Neutralizing Antibodies/*immunology
SARS Virus/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Adult ; Aged ; Angiotensin-Converting Enzyme 2 ; Antibody Affinity ; B-Lymphocyte Subsets/immunology ; Binding Sites ; Cross Reactions ; Epitopes ; Female ; Humans ; Immunologic Memory ; Male ; Middle Aged ; Neutralization Tests ; Peptidyl-Dipeptidase A/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Protein Domains ; Receptors, Coronavirus ; Receptors, Virus/chemistry ; Receptors, Virus/metabolism ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/immunology ; Somatic Hypermutation, Immunoglobulin ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2.
Autorzy :
Chan KK; Orthogonal Biologics, Champaign, IL 61821, USA.
Dorosky D; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Sharma P; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA.
Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Kranz DM; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.
Procko E; Department of Biochemistry and Cancer Center at Illinois, University of Illinois, Urbana, IL 61801, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Sep 04; Vol. 369 (6508), pp. 1261-1265. Date of Electronic Publication: 2020 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Engineering*
Betacoronavirus/*metabolism
Peptidyl-Dipeptidase A/*genetics
Peptidyl-Dipeptidase A/*metabolism
Receptors, Virus/*genetics
Receptors, Virus/*metabolism
Spike Glycoprotein, Coronavirus/*metabolism
Amino Acid Substitution ; Angiotensin-Converting Enzyme 2 ; Binding Sites ; Binding, Competitive ; Cell Line ; Humans ; Models, Molecular ; Mutagenesis ; Mutation ; Peptidyl-Dipeptidase A/chemistry ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Receptors, Coronavirus ; Receptors, Virus/chemistry ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry
Czasopismo naukowe
Tytuł :
A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition.
Autorzy :
Dieterle ME; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Haslwanter D; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bortz RH 3rd; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Lasso G; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Vergnolle O; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Laudermilch E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Florez C; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Chemistry and Life Science, United States Military Academy at West Point, West Point, NY 10996, USA.
Mengotto A; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Kimmel D; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Malonis RJ; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Georgiev G; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Quiroz J; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Barnhill J; Department of Chemistry and Life Science, United States Military Academy at West Point, West Point, NY 10996, USA.
Pirofski LA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Daily JP; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA. Electronic address: andrew.s..
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
Jangra RK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Cell host & microbe [Cell Host Microbe] 2020 Sep 09; Vol. 28 (3), pp. 486-496.e6. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus/*pathogenicity
Coronavirus Infections/*virology
Pneumonia, Viral/*virology
Spike Glycoprotein, Coronavirus/*physiology
Vesicular stomatitis Indiana virus/*physiology
Angiotensin-Converting Enzyme 2 ; Animals ; Antiviral Agents/pharmacology ; Betacoronavirus/genetics ; Betacoronavirus/physiology ; COVID-19 ; COVID-19 Vaccines ; Cell Line ; Chlorocebus aethiops ; Coronavirus Infections/drug therapy ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Drug Evaluation, Preclinical ; Host Microbial Interactions/drug effects ; Host Microbial Interactions/genetics ; Host Microbial Interactions/physiology ; Humans ; Mutation ; Neutralization Tests ; Pandemics/prevention & control ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/physiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Receptors, Virus/genetics ; Receptors, Virus/physiology ; Recombination, Genetic ; SARS-CoV-2 ; Serine Endopeptidases/physiology ; Spike Glycoprotein, Coronavirus/genetics ; Vero Cells ; Vesicular stomatitis Indiana virus/genetics ; Viral Vaccines/genetics ; Viral Vaccines/immunology ; Virus Internalization ; Virus Replication/genetics
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19.
Autorzy :
Rappazzo CG
Tse LV
Kaku CI
Wrapp D
Sakharkar M
Huang D
Deveau LM
Yockachonis TJ
Herbert AS
Battles MB
O'Brien CM
Brown ME
Geoghegan JC
Belk J
Peng L
Yang L
Scobey TD
Burton DR
Nemazee D
Dye JM
Voss JE
Gunn BM
McLellan JS
Baric RS
Gralinski LE
Walker LM
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Źródło :
BioRxiv : the preprint server for biology [bioRxiv] 2020 Nov 17. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Preprint
Tytuł :
Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays.
Autorzy :
Gupta Y; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Department of Medicine, Loyola University Medical Center, Chicago, IL 60153, USA.
Maciorowski D; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Loyola University Chicago, Chicago, IL, USA.
Zak SE; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA.
Jones KA; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Kathayat RS; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Azizi SA; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Mathur R; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA.
Pearce CM; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA.
Ilc DJ; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Loyola University Chicago, Chicago, IL, USA.
Husein H; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Loyola University Chicago, Chicago, IL, USA.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Bharti A; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, CA 92093, USA.
Rathi B; Department of Medicine, Loyola University Medical Center, Chicago, IL 60153, USA; Laboratory for Translational Chemistry and Drug Discovery, Hansraj College, University of Delhi, India.
Durvasula R; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Department of Medicine, Loyola University Medical Center, Chicago, IL 60153, USA.
Becker DP; Loyola University Chicago, Chicago, IL, USA.
Dickinson BC; Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA 98402, USA.
Kempaiah P; Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153, USA; Department of Medicine, Loyola University Medical Center, Chicago, IL 60153, USA. Electronic address: .
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Źródło :
Methods (San Diego, Calif.) [Methods] 2021 Jan 14. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
Autorzy :
Rappazzo CG; Adimab, LLC, Lebanon, NH 03766, USA.
Tse LV; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kaku CI; Adimab, LLC, Lebanon, NH 03766, USA.
Wrapp D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Sakharkar M; Adimab, LLC, Lebanon, NH 03766, USA.
Huang D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Deveau LM; Adimab, LLC, Lebanon, NH 03766, USA.
Yockachonis TJ; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.
Battles MB; Adimab, LLC, Lebanon, NH 03766, USA.
O'Brien CM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.; The Geneva Foundation, Tacoma, WA 98402, USA.
Brown ME; Adimab, LLC, Lebanon, NH 03766, USA.
Geoghegan JC; Adimab, LLC, Lebanon, NH 03766, USA.
Belk J; Adimab, LLC, Lebanon, NH 03766, USA.
Peng L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Yang L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Hou Y; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Scobey TD; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139, USA.
Nemazee D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Voss JE; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Gunn BM; Paul G. Allen School of Global Animal Health, Washington State University, Pullman, WA 99164, USA.
McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Baric RS; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. .; Departments of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Gralinski LE; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. .
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA. .; Adagio Therapeutics, Inc., Waltham, MA 02451, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 823-829. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Viral/*immunology
Betacoronavirus/*immunology
Broadly Neutralizing Antibodies/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/metabolism ; Antibodies, Viral/genetics ; Antibodies, Viral/metabolism ; Antibody Affinity ; Binding Sites ; Binding Sites, Antibody ; Broadly Neutralizing Antibodies/genetics ; Broadly Neutralizing Antibodies/metabolism ; COVID-19/prevention & control ; COVID-19/therapy ; Cell Surface Display Techniques ; Directed Molecular Evolution ; Epitopes/immunology ; Humans ; Immunization, Passive ; Immunoglobulin Fc Fragments/immunology ; Mice, Inbred BALB C ; Protein Domains ; Protein Engineering ; Receptors, Coronavirus/metabolism ; SARS Virus/immunology ; Severe Acute Respiratory Syndrome/immunology ; Severe Acute Respiratory Syndrome/prevention & control ; Severe Acute Respiratory Syndrome/therapy ; Spike Glycoprotein, Coronavirus/metabolism
SCR Protocol :
COVID-19 serotherapy
Czasopismo naukowe
Tytuł :
Heparin: A simplistic repurposing to prevent SARS-CoV-2 transmission in light of its in-vitro nanomolar efficacy.
Autorzy :
Gupta Y; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA.
Maciorowski D; Loyola University Chicago, Chicago, IL, USA.
Zak SE; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA, USA.
Kulkarni CV; School of Natural Sciences, University of Central Lancashire, Preston, UK.
Herbert AS; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Durvasula R; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA.
Fareed J; Department of Molecular Pharmacology & Neuroscience, Loyola University Chicago, Chicago, IL, USA.
Dye JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA; The Geneva Foundation, 917 Pacific Avenue, Tacoma, WA, USA.
Kempaiah P; Infectious Diseases, Mayo Clinic, Jacksonville, FL, USA. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Apr 26; Vol. 183, pp. 203-212. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever.
Autorzy :
Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Maurer DP; Adimab, LLC, Lebanon, NH 03766, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA; The Geneva Foundation, Tacoma, WA 98402, USA.
Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Vergnolle O; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cross RW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA.
Abelson DM; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Moyer CL; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Mishra AK; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Aguilan JT; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Pauli NT; Adimab, LLC, Lebanon, NH 03766, USA.
Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
Nyakatura EK; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Hellert J; Structural Virology Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, Paris 75724, France.
Quevedo G; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Lobel L; Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Balinandi S; Uganda Virus Research Institute, Entebbe, Uganda.
Lutwama JJ; Uganda Virus Research Institute, Entebbe, Uganda.
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA.
Geisbert TW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA.
Rey FA; Structural Virology Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, Paris 75724, France.
Sidoli S; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
McLellan JS; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Lai JR; Deparment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA 92121, USA. Electronic address: .
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address: .
Walker LM; Adimab, LLC, Lebanon, NH 03766, USA; Adagio Therapeutics, Inc., Waltham, MA 02451, USA. Electronic address: .
Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Cell [Cell] 2021 May 26. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes.
Autorzy :
Voss WN; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Hou YJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Delidakis G; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Kim JE; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
Javanmardi K; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Horton AP; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Bartzoka F; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Paresi CJ; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA.
Tanno Y; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Chou CW; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Abbasi SA; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA.
Pickens W; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
George K; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Boutz DR; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; CCDC Army Research Laboratory-South, The University of Texas at Austin, Austin, TX, USA.
Towers DM; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
McDaniel JR; Biomedicine Design, Pfizer, Cambridge, MA, USA.
Billick D; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Goike J; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Rowe L; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.; Tulane National Primate Research Center Department of Microbiology 18703 Three Rivers Road Covington, LA, USA.
Batra D; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Pohl J; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Lee J; Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Gangappa S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Sambhara S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Gadush M; Center for Biomedical Research Support, The University of Texas at Austin, Austin, TX, USA.
Wang N; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Person MD; Center for Biomedical Research Support, The University of Texas at Austin, Austin, TX, USA.
Iverson BL; Department of Chemistry, The University of Texas at Austin, Austin, TX, USA.
Gollihar JD; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; CCDC Army Research Laboratory-South, The University of Texas at Austin, Austin, TX, USA.; Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.
Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA.
Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, USA.
Finkelstein IJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Georgiou G; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.; Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
Lavinder JJ; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. .; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Ippolito GC; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA. .; Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.; Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jun 04; Vol. 372 (6546), pp. 1108-1112. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
Immunoglobulin G/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Animals ; Antibodies, Monoclonal/blood ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/chemistry ; Antibodies, Viral/blood ; Antibodies, Viral/chemistry ; Antibody Affinity ; COVID-19/prevention & control ; Epitopes/immunology ; Humans ; Immune Evasion ; Immunoglobulin G/blood ; Immunoglobulin G/chemistry ; Immunoglobulin Heavy Chains/immunology ; Immunoglobulin Variable Region/immunology ; Mice ; Mice, Inbred BALB C ; Mutation ; Protein Domains ; Proteomics ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
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