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Wyszukujesz frazę ""Hermit MB"" wg kryterium: Autor


Tytuł :
A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Autorzy :
Østergaard H; Global Drug Discovery and.
Lund J; Global Drug Discovery and.
Greisen PJ; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Kjellev S; Global Drug Discovery and.
Henriksen A; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Lorenzen N; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Johansson E; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Røder G; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Rasch MG; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Johnsen LB; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Egebjerg T; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Lund S; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Rahbek-Nielsen H; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Gandhi PS; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Lamberth K; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Loftager M; Global Drug Discovery and.
Andersen LM; Global Drug Discovery and.
Bonde AC; Global Drug Discovery and.
Stavenuiter F; Global Drug Discovery and.
Madsen DE; Global Drug Discovery and.
Li X; Discovery Technology China, Novo Nordisk A/S, Beijing, China.
Holm TL; Global Drug Discovery and.
Ley CD; Global Drug Discovery and.
Thygesen P; Global Drug Discovery and.
Zhu H; Discovery Technology China, Novo Nordisk A/S, Beijing, China.
Zhou R; Discovery Technology China, Novo Nordisk A/S, Beijing, China.
Thorn K; Global Drug Discovery and.
Yang Z; Discovery Technology China, Novo Nordisk A/S, Beijing, China.
Hermit MB; Global Drug Discovery and.
Bjelke JR; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Hansen BG; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and.
Hilden I; Global Drug Discovery and.
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Źródło :
Blood [Blood] 2021 Oct 07; Vol. 138 (14), pp. 1258-1268.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*therapeutic use
Hemophilia A/*drug therapy
Hemorrhage/*drug therapy
Animals ; Factor IXa/antagonists & inhibitors ; Factor VIIIa/therapeutic use ; Factor X/antagonists & inhibitors ; Female ; Humans ; Male ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
FIXing postinfusion monitoring: Assay experiences with N9-GP (nonacog beta pegol; Refixia ).
Autorzy :
Ezban M; Novo Nordisk A/S, Måløv, Denmark.
Hermit MB; Novo Nordisk A/S, Måløv, Denmark.
Persson E; Novo Nordisk A/S, Måløv, Denmark.
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Źródło :
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2019 Jan; Vol. 25 (1), pp. 154-161.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Blood Coagulation Tests/*methods
Factor IX/*analysis
Polyethylene Glycols/*analysis
Drug Monitoring ; Factor IX/therapeutic use ; Hemophilia B/drug therapy ; Humans ; Partial Thromboplastin Time ; Polyethylene Glycols/therapeutic use ; Recombinant Proteins/analysis ; Recombinant Proteins/therapeutic use
Czasopismo naukowe
Tytuł :
Evaluating IL-21 as a Potential Therapeutic Target in Crohn's Disease.
Autorzy :
Holm TL; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Tornehave D; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Søndergaard H; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Kvist PH; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Sondergaard BC; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Hansen L; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Hermit MB; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Holgersen K; Novo Nordisk LIFE In Vivo Pharmacology Centre, Frederiksberg, Denmark.
Vergo S; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Frederiksen KS; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Haase C; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Lundsgaard D; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
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Źródło :
Gastroenterology research and practice [Gastroenterol Res Pract] 2018 Apr 10; Vol. 2018, pp. 5962624. Date of Electronic Publication: 2018 Apr 10 (Print Publication: 2018).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Pharmacokinetics of an anti-TFPI monoclonal antibody (concizumab) blocking the TFPI interaction with the active site of FXa in Cynomolgus monkeys after iv and sc administration.
Autorzy :
Agersø H; Research and Development, Novo Nordisk A/S, Denmark. Electronic address: .
Overgaard RV; Research and Development, Novo Nordisk A/S, Denmark.
Petersen MB; Research and Development, Novo Nordisk A/S, Denmark.
Hansen L; Research and Development, Novo Nordisk A/S, Denmark.
Hermit MB; Research and Development, Novo Nordisk A/S, Denmark.
Sørensen MH; Research and Development, Novo Nordisk A/S, Denmark.
Petersen LC; Research and Development, Novo Nordisk A/S, Denmark.
Hilden I; Research and Development, Novo Nordisk A/S, Denmark.
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2014 Jun 02; Vol. 56, pp. 65-9. Date of Electronic Publication: 2014 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Antibodies, Monoclonal, Humanized/*pharmacokinetics
Factor Xa/*metabolism
Lipoproteins/*metabolism
Administration, Intravenous ; Animals ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/blood ; Catalytic Domain ; Injections, Subcutaneous ; Lipoproteins/immunology ; Macaca fascicularis
Czasopismo naukowe
Tytuł :
Hyperglycosylation prolongs the circulation of coagulation factor IX.
Autorzy :
Bolt G; Mammalian Cell Technology Protein Purification Exploratory ADME Biopharmaceuticals, Novo Nordisk A/S, Måløv, Denmark.
Bjelke JR
Hermit MB
Hansen L
Karpf DM
Kristensen C
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2012 Nov; Vol. 10 (11), pp. 2397-8.
Typ publikacji :
Letter
MeSH Terms :
Factor IX/*chemistry
Animals ; DNA, Complementary/metabolism ; Drug Design ; Glycosylation ; Hemophilia A/drug therapy ; Hemophilia A/genetics ; Humans ; Mice ; Mutagenesis, Site-Directed ; Mutation ; Polysaccharides/chemistry ; Recombinant Proteins/chemistry ; Time Factors
Opinia redakcyjna
Tytuł :
Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model.
Autorzy :
Hilden I; Biopharmaceuticals Research Unit, Novo Nordisk, Maaloev, Denmark. />Lauritzen B
Sørensen BB
Clausen JT
Jespersgaard C
Krogh BO
Bowler AN
Breinholt J
Gruhler A
Svensson LA
Petersen HH
Petersen LC
Balling KW
Hansen L
Hermit MB
Egebjerg T
Friederichsen B
Ezban M
Bjørn SE
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Źródło :
Blood [Blood] 2012 Jun 14; Vol. 119 (24), pp. 5871-8. Date of Electronic Publication: 2012 May 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Molecular*
Antibodies, Blocking/*pharmacology
Antibodies, Monoclonal, Humanized/*pharmacology
Antibodies, Monoclonal, Humanized/*therapeutic use
Factor Xa/*metabolism
Hemophilia A/*drug therapy
Hemostasis/*drug effects
Lipoproteins/*metabolism
Animals ; Antibodies, Blocking/administration & dosage ; Antibodies, Blocking/therapeutic use ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Neutralizing/pharmacology ; Bleeding Time ; Blood Coagulation/drug effects ; Cross Reactions/drug effects ; Disease Models, Animal ; Epitopes/immunology ; Factor VIII/pharmacology ; Factor Xa/immunology ; Female ; Fibrin/metabolism ; HEK293 Cells ; Hemophilia A/blood ; Human Umbilical Vein Endothelial Cells ; Humans ; Neutralization Tests ; Protein Binding/drug effects ; Protein Structure, Tertiary ; Rabbits ; Species Specificity ; Thromboplastin/pharmacology
Czasopismo naukowe
Tytuł :
Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia.
Autorzy :
Maroney SA; Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA.
Cooley BC
Ferrel JP
Bonesho CE
Nielsen LV
Johansen PB
Hermit MB
Petersen LC
Mast AE
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Mar 06; Vol. 109 (10), pp. 3927-31. Date of Electronic Publication: 2012 Feb 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hemophilia A/*metabolism
Lipoproteins/*genetics
Lipoproteins/*metabolism
Animals ; Blood Coagulation ; Disease Models, Animal ; Female ; Genetic Complementation Test ; Genotype ; Hematopoietic Stem Cells/cytology ; Hemophilia A/drug therapy ; Hemophilia A/genetics ; Hemorrhage ; Liver/embryology ; Liver Transplantation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Phenotype
Czasopismo naukowe
Tytuł :
Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide.
Autorzy :
Østergaard H; Haemostasis Biology, Novo Nordisk A/S, Maaloev, Denmark. />Bjelke JR
Hansen L
Petersen LC
Pedersen AA
Elm T
Møller F
Hermit MB
Holm PK
Krogh TN
Petersen JM
Ezban M
Sørensen BB
Andersen MD
Agersø H
Ahmadian H
Balling KW
Christiansen ML
Knobe K
Nichols TC
Bjørn SE
Tranholm M
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Źródło :
Blood [Blood] 2011 Aug 25; Vol. 118 (8), pp. 2333-41. Date of Electronic Publication: 2011 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Factor IX/*chemistry
Factor IX/*metabolism
Animals ; Binding Sites ; Disease Models, Animal ; Dogs ; Factor IX/genetics ; Female ; Half-Life ; Hemophilia B/blood ; Hemophilia B/drug therapy ; Hemophilia B/genetics ; Hemostatics/blood ; Hemostatics/chemistry ; Hemostatics/pharmacology ; Humans ; In Vitro Techniques ; Kinetics ; Male ; Mice ; Mice, Mutant Strains ; Polyethylene Glycols/chemistry ; Polysaccharides/chemistry ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology ; Swine ; Swine, Miniature
Czasopismo naukowe
Tytuł :
Prolonged half-life of glycoPEGylated rFVIIa variants compared to native rFVIIa.
Autorzy :
Karpf DM; Novo Nordisk A/S, Novo Nordisk Park, Maalov, Denmark. />Sørensen BB
Hermit MB
Holmberg HL
Tranholm M
Bysted BV
Groth AV
Bjørn SE
Stennicke HR
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Źródło :
Thrombosis research [Thromb Res] 2011 Aug; Vol. 128 (2), pp. 191-5. Date of Electronic Publication: 2011 Mar 22.
Typ publikacji :
Journal Article
MeSH Terms :
Factor VIIa/*pharmacokinetics
Hemophilia A/*metabolism
Polyethylene Glycols/*chemistry
Polyethylene Glycols/*pharmacokinetics
Animals ; Disease Models, Animal ; Dogs ; Factor VIIa/chemistry ; Factor VIIa/pharmacology ; Female ; Glycosylation ; Half-Life ; Hemorrhage/etiology ; Hemorrhage/metabolism ; Humans ; Male ; Mice ; Polyethylene Glycols/pharmacology ; Recombinant Proteins/chemistry ; Recombinant Proteins/pharmacokinetics ; Recombinant Proteins/pharmacology ; Swine ; Swine, Miniature ; Tail/blood supply
Czasopismo naukowe
Tytuł :
Clearance of rFVIIa and NN1731 after intravenous administration to Beagle dogs.
Autorzy :
Agersø H; Research and Development, Novo Nordisk A/S, Novo Nordisk Park, 2760 Maaloev, Denmark. />Kristensen NR
Østergaard H
Karpf DM
Hermit MB
Pelzer H
Petersen LC
Ezban M
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2011 Apr 18; Vol. 42 (5), pp. 578-83. Date of Electronic Publication: 2011 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Factor VII/*pharmacokinetics
Factor VIIa/*pharmacokinetics
Animals ; Antithrombin Proteins/physiology ; Blood Coagulation/drug effects ; Data Interpretation, Statistical ; Dogs ; Factor VII/administration & dosage ; Factor VII/pharmacology ; Factor VIIa/administration & dosage ; Factor VIIa/pharmacology ; Half-Life ; Injections, Intravenous ; Metabolic Clearance Rate ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/pharmacokinetics ; Recombinant Proteins/pharmacology
Czasopismo naukowe
Tytuł :
Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin.
Autorzy :
Petersen LC; Biopharmaceuticals Research Unit, Novo Nordisk A/S, Måløv, Denmark. />Karpf DM
Agersø H
Hermit MB
Pelzer H
Persson E
Nichols TC
Ezban M
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Źródło :
British journal of haematology [Br J Haematol] 2011 Jan; Vol. 152 (1), pp. 99-107. Date of Electronic Publication: 2010 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antithrombin Proteins/*physiology
Coagulants/*pharmacokinetics
Factor VII/*pharmacokinetics
Hemophilia A/*blood
Animals ; Blood Coagulation/drug effects ; Blood Coagulation Factor Inhibitors/physiology ; Coagulants/antagonists & inhibitors ; Disease Models, Animal ; Dogs ; Factor VII/antagonists & inhibitors ; Factor VIIa/antagonists & inhibitors ; Half-Life ; Male ; Recombinant Proteins/antagonists & inhibitors ; Recombinant Proteins/blood ; Thrombelastography/methods
Czasopismo naukowe
Tytuł :
Effects of a recombinant FVIIa analogue, NN1731, on blood loss and survival after liver trauma in the pig.
Autorzy :
Zaar M; Department of Anaesthesia, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark. />Secher NH
Johansson PI
Vainer B
Ezban M
Agersø H
Madsen PL
Lomholt N
Hermit MB
Lauritzen B
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Źródło :
British journal of anaesthesia [Br J Anaesth] 2009 Dec; Vol. 103 (6), pp. 840-7. Date of Electronic Publication: 2009 Oct 06.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Factor VII/*therapeutic use
Hemorrhage/*drug therapy
Hemostatics/*therapeutic use
Liver/*injuries
Liver Diseases/*drug therapy
Animals ; Disease Models, Animal ; Factor VII/administration & dosage ; Factor VIIa/administration & dosage ; Factor VIIa/therapeutic use ; Hemorrhage/physiopathology ; Hemostatics/administration & dosage ; Injections, Intramuscular ; Injections, Intravenous ; Liver Diseases/physiopathology ; Oxygen Consumption/drug effects ; Random Allocation ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/therapeutic use ; Survival Analysis ; Sus scrofa ; Swine ; Swine, Miniature ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Autorzy :
Marinozzi M; Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo, 1- I-06123 Perugia, Italy.
Serpi M
Amori L
Gavilan Diaz M
Costantino G
Meyer U
Flor PJ
Gasparini F
Heckendorn R
Kuhn R
Giorgi G
Hermit MB
Thomsen C
Pellicciari R
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2007 May 01; Vol. 15 (9), pp. 3161-70. Date of Electronic Publication: 2007 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclopropanes/*chemical synthesis
Cyclopropanes/*pharmacology
Glycine/*analogs & derivatives
Receptors, Metabotropic Glutamate/*agonists
Animals ; Crystallography, X-Ray ; Cyclopropanes/chemistry ; Drug Evaluation, Preclinical ; Glycine/chemical synthesis ; Glycine/chemistry ; Glycine/pharmacology ; Humans ; Ligands ; Models, Molecular ; Molecular Structure ; Rats ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe

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