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Wyświetlanie 1-10 z 10
Tytuł :
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation.
Autorzy :
Relitti N; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Saraswati AP; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Chemi G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Brindisi M; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Brogi S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy.
Herp D; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
Schmidtkunz K; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
Saccoccia F; Institute of Biochemistry and Cell Biology, CNR, Campus A. Buzzati-Traverso. Via E. Ramarini 32, 00015, Monterotondo, Rome, Italy.
Ruberti G; Institute of Biochemistry and Cell Biology, CNR, Campus A. Buzzati-Traverso. Via E. Ramarini 32, 00015, Monterotondo, Rome, Italy.
Ulivieri C; Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Vanni F; Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Sarno F; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138, Naples, Italy.
Altucci L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138, Naples, Italy.
Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Jung M; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 15; Vol. 212, pp. 112998. Date of Electronic Publication: 2020 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Histone Deacetylase 6/*antagonists & inhibitors
Histone Deacetylase Inhibitors/*pharmacology
Quinolones/*pharmacology
Animals ; Cell Line ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Histone Deacetylase 6/metabolism ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Mice ; Models, Molecular ; Molecular Structure ; Quinolones/chemical synthesis ; Quinolones/chemistry ; Recombinant Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Syntheses of Thailandepsin B Pseudo-Natural Products: Access to New Highly Potent HDAC Inhibitors via Late-Stage Modification.
Autorzy :
Brosowsky J; Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, 79104, Freiburg, Germany.
Lutterbeck M; Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, 79104, Freiburg, Germany.
Liebich A; Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, 79104, Freiburg, Germany.
Keller M; Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, 79104, Freiburg, Germany.
Herp D; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104, Freiburg, Germany.
Vogelmann A; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104, Freiburg, Germany.
Jung M; Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104, Freiburg, Germany.
Breit B; Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, 79104, Freiburg, Germany.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Dec 09; Vol. 26 (69), pp. 16241-16245. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation.
Autorzy :
Saraswati AP; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Relitti N; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Brindisi M; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Osko JD; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Chemi G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Federico S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Grillo A; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Brogi S; Department of Pharmacy, University of Pisa, via Bonanno 6, 56126, Pisa, Italy.
McCabe NH; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, U.K.
Turkington RC; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, U.K.
Ibrahim O; School of Dental Science, Trinity College Dublin, Lincoln Place, Dublin 2, Ireland.
O'Sullivan J; School of Dental Science, Trinity College Dublin, Lincoln Place, Dublin 2, Ireland.
Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Ghanim M; School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College, 152-160, Pearse Street, Dublin 2, Ireland.
Kelly VP; School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College, 152-160, Pearse Street, Dublin 2, Ireland.
Zisterer D; School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College, 152-160, Pearse Street, Dublin 2, Ireland.
Amet R; School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College, 152-160, Pearse Street, Dublin 2, Ireland.
Hannon Barroeta P; School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College, 152-160, Pearse Street, Dublin 2, Ireland.
Vanni F; Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Ulivieri C; Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Herp D; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
Sarno F; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli″, 80138 Naples, Italy.
Di Costanzo A; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli″, 80138 Naples, Italy.
Saccoccia F; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), via E. Ramarini 32, 00015 Monterotondo, Rome, Italy.
Ruberti G; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), via E. Ramarini 32, 00015 Monterotondo, Rome, Italy.
Jung M; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
Altucci L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli″, 80138 Naples, Italy.
Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Christianson DW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.
Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy.
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Źródło :
ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Sep 29; Vol. 11 (11), pp. 2268-2276. Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 ( Sm HDAC8) Inhibitors as Multistage Antischistosomal Agents.
Autorzy :
Saccoccia F; Institute of Biochemistry and Cell Biology (IBBC) , National Research Council (CNR) , Campus A. Buzzati-Traverso, via E. Ramarini 32 , 00015 Monterotondo ( Rome ), Italy.
Brindisi M; Department of Excellence of Pharmacy , University of Napoli Federico II , via D. Montesano 49 , 80131 Naples , Italy.
Gimmelli R; Institute of Biochemistry and Cell Biology (IBBC) , National Research Council (CNR) , Campus A. Buzzati-Traverso, via E. Ramarini 32 , 00015 Monterotondo ( Rome ), Italy.
Relitti N; Department of Excellence of Biotechnology, Chemistry and Pharmacy , University of Siena , via Aldo Moro 2 , 53100 , Siena , Italy.
Guidi A; Institute of Biochemistry and Cell Biology (IBBC) , National Research Council (CNR) , Campus A. Buzzati-Traverso, via E. Ramarini 32 , 00015 Monterotondo ( Rome ), Italy.
Saraswati AP; Department of Excellence of Biotechnology, Chemistry and Pharmacy , University of Siena , via Aldo Moro 2 , 53100 , Siena , Italy.
Cavella C; Department of Excellence of Biotechnology, Chemistry and Pharmacy , University of Siena , via Aldo Moro 2 , 53100 , Siena , Italy.
Brogi S; Department of Excellence of Biotechnology, Chemistry and Pharmacy , University of Siena , via Aldo Moro 2 , 53100 , Siena , Italy.; Department of Pharmacy , University of Pisa , via Bonanno 6 , 56126 , Pisa , Italy.
Chemi G; Department of Excellence of Biotechnology, Chemistry and Pharmacy , University of Siena , via Aldo Moro 2 , 53100 , Siena , Italy.
Butini S; Department of Excellence of Biotechnology, Chemistry and Pharmacy , University of Siena , via Aldo Moro 2 , 53100 , Siena , Italy.
Papoff G; Institute of Biochemistry and Cell Biology (IBBC) , National Research Council (CNR) , Campus A. Buzzati-Traverso, via E. Ramarini 32 , 00015 Monterotondo ( Rome ), Italy.
Senger J; Institute of Pharmaceutical Sciences , University of Freiburg , Albertstraße 25 , 79104 Freiburg , Germany.
Herp D; Institute of Pharmaceutical Sciences , University of Freiburg , Albertstraße 25 , 79104 Freiburg , Germany.
Jung M; Institute of Pharmaceutical Sciences , University of Freiburg , Albertstraße 25 , 79104 Freiburg , Germany.
Campiani G; Department of Excellence of Biotechnology, Chemistry and Pharmacy , University of Siena , via Aldo Moro 2 , 53100 , Siena , Italy.
Gemma S; Department of Excellence of Biotechnology, Chemistry and Pharmacy , University of Siena , via Aldo Moro 2 , 53100 , Siena , Italy.
Ruberti G; Institute of Biochemistry and Cell Biology (IBBC) , National Research Council (CNR) , Campus A. Buzzati-Traverso, via E. Ramarini 32 , 00015 Monterotondo ( Rome ), Italy.
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Źródło :
ACS infectious diseases [ACS Infect Dis] 2020 Jan 10; Vol. 6 (1), pp. 100-113. Date of Electronic Publication: 2019 Nov 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anthelmintics/*pharmacology
Drug Discovery/*methods
Histone Deacetylase Inhibitors/*pharmacology
Schistosoma mansoni/*drug effects
Animals ; Crystallography, X-Ray ; Female ; High-Throughput Screening Assays ; Histone Deacetylase Inhibitors/isolation & purification ; Male ; Mice ; Molecular Docking Simulation ; Phenotype ; Schistosoma mansoni/enzymology ; Structure-Activity Relationship
Czasopismo naukowe
    Wyświetlanie 1-10 z 10

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