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Tytuł :
Oxygen gradient and tumor heterogeneity: The chronicle of a toxic relationship.
Autorzy :
Pandkar MR; Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, Madhya Pradesh 462066, India.
Dhamdhere SG; Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, Madhya Pradesh 462066, India.
Shukla S; Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, Madhya Pradesh 462066, India. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2021 Aug; Vol. 1876 (1), pp. 188553. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genetic Heterogeneity*
Tumor Microenvironment*
Neoplasms/*metabolism
Oxygen/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Communication ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia-Inducible Factor 1/genetics ; Hypoxia-Inducible Factor 1/metabolism ; Neoplasms/genetics ; Neoplasms/pathology ; Signal Transduction ; Tumor Hypoxia ; Warburg Effect, Oncologic
Czasopismo naukowe
Tytuł :
High-grade Follicular Lymphomas Exhibit Clinicopathologic, Cytogenetic, and Molecular Diversity Extending Beyond Grades 3A and 3B.
Autorzy :
Laurent C; Department of Pathology, Institut Universitaire du Cancer, CHU de Toulouse.; INSERM, U.1037, Centre de Recherche en Cancerologie de Toulouse-Purpan, laboratoire d'excellence TOUCAN, Toulouse.
Adélaïde J; Departments of Predictive Oncology.
Guille A; Departments of Predictive Oncology.
Tesson B; Institut Carnot CALYM.
Gat E; Institut Carnot CALYM.
Evrard S; Department of Pathology, Institut Universitaire du Cancer, CHU de Toulouse.
Escudié F; Department of Pathology, Institut Universitaire du Cancer, CHU de Toulouse.
Syrykh C; Department of Pathology, Institut Universitaire du Cancer, CHU de Toulouse.
Canioni D; Department of Pathology, Hôpital Necker.
Fabiani B; Department of Pathology, AP-HP, Hôpital Saint-Antoine.
Meignin V; Department of Pathology, Hôpital Saint-Louis, Paris.
Chassagne-Clement C; Department of Pathology, Centre Léon Bérard.
Dartigues P; Department of Pathology, Institut Gustave Roussy, Villejuif.
Traverse-Glehen A; Department of Pathology, Centre Hospitalier Lyon-Sud.
Parrens M; Département de Pathologie, Hôpital du Haut Lévêque, Bordeaux.
Huet S; Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Laboratoire d'Hématologie, Pierre-Bénite.
Copie-Bergman C; LYSA-P, Hôpital Henri Mondor, Creteil.
Salles G; Department of Hematology, Cancer Research Center of Lyon, Lyon.
Birnbaum D; Departments of Predictive Oncology.
Brousset P; Department of Pathology, Institut Universitaire du Cancer, CHU de Toulouse.; INSERM, U.1037, Centre de Recherche en Cancerologie de Toulouse-Purpan, laboratoire d'excellence TOUCAN, Toulouse.
Morschhauser F; University Lille, CHU Lille, ULR 7365, Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA), Lille, France.
Xerri L; Pathology and Tumor Immunology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm U1068, CNRS UMR7258, Aix-Marseille University, Marseille.
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Corporate Authors :
Lymphoma Study Association (LYSA)
Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2021 Oct 01; Vol. 45 (10), pp. 1324-1336.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytogenetic Analysis*
Genetic Heterogeneity*
Biomarkers, Tumor/*genetics
Lymphoma, Follicular/*genetics
Lymphoma, Follicular/*pathology
Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Comparative Genomic Hybridization ; Female ; France ; Gene Rearrangement ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Lymphoma, Follicular/drug therapy ; Lymphoma, Follicular/mortality ; Male ; Middle Aged ; Mutation ; Neoplasm Grading ; Phenotype ; Predictive Value of Tests ; Time Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Reliability and reproducibility among different platforms for tumour BRCA testing in ovarian cancer: a study of the Italian NGS Network.
Autorzy :
Fumagalli C; Unit of Histopathology and Molecular Diagnostics, Division of Pathology and Laboratory Medicine, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
Guerini-Rocco E; Unit of Histopathology and Molecular Diagnostics, Division of Pathology and Laboratory Medicine, IEO, European Institute of Oncology, IRCCS, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Buttitta F; Laboratory of Diagnostic Molecular Oncology, Center for Advanced Studies and Technology (CAST), University of Chieti, Chieti, Italy.; Department of Medical and Oral Sciences and Biotechnologies, University of Chieti, Chieti, Italy.
Iapicca P; SOPHiA GENETICS SA, Headquarters, Saint Sulpice, Switzerland.
You W; SOPHiA GENETICS SA, Headquarters, Saint Sulpice, Switzerland.
Mauri M; SOPHiA GENETICS SA, Headquarters, Saint Sulpice, Switzerland.
Felicioni L; Department of Pathology, SS Annunziata Clinical Hospital, Chieti, Italy.
Troncone G; Department of Public Health, University of Naples Federico II, Naples, Italy.
Malapelle U; Department of Public Health, University of Naples Federico II, Naples, Italy.
Scarpa A; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.; ARC-Net Centre for Applied Research on Cancer, Verona, Italy.
Zamboni G; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.; Department of Pathology, IRCCS Sacro Cuore - Don Calabria-Negrar, Negrar, Italy.
Calistri D; Laboratory of Biosciences, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Srl, Meldola, Italy.
Barberis M; Unit of Histopathology and Molecular Diagnostics, Division of Pathology and Laboratory Medicine, IEO, European Institute of Oncology, IRCCS, Milan, Italy .
Marchetti A; Laboratory of Diagnostic Molecular Oncology, Center for Advanced Studies and Technology (CAST), University of Chieti, Chieti, Italy.; Department of Medical and Oral Sciences and Biotechnologies, University of Chieti, Chieti, Italy.
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Źródło :
Journal of clinical pathology [J Clin Pathol] 2021 Oct; Vol. 74 (10), pp. 668-672. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Comparative Study; Journal Article; Multicenter Study
MeSH Terms :
Genetic Heterogeneity*
Genetic Testing*
BRCA1 Protein/*genetics
BRCA2 Protein/*genetics
Biomarkers, Tumor/*genetics
Ovarian Neoplasms/*genetics
Computational Biology ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Italy ; Observer Variation ; Ovarian Neoplasms/pathology ; Predictive Value of Tests ; Reproducibility of Results ; Workflow
Czasopismo naukowe
Tytuł :
Genetic and Epigenetic Factors of Takotsubo Syndrome: A Systematic Review.
Autorzy :
Ferradini V; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Vacca D; Tumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.
Belmonte B; Tumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.
Mango R; Cardiology Unit, Department of Emergency and Critical Care, Policlinico Tor Vergata, 00133 Rome, Italy.
Scola L; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, 90134 Palermo, Italy.
Novelli G; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Balistreri CR; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, 90134 Palermo, Italy.
Sangiuolo F; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 13; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 13.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Genetic Heterogeneity*
Genetic Predisposition to Disease*
COVID-19/*complications
Epigenesis, Genetic/*immunology
Takotsubo Cardiomyopathy/*genetics
Biomarkers/analysis ; COVID-19/immunology ; COVID-19/virology ; DNA Copy Number Variations/immunology ; Genetic Loci/immunology ; Heart Ventricles/immunology ; Heart Ventricles/pathology ; Humans ; Medical History Taking ; Polymorphism, Single Nucleotide/immunology ; SARS-CoV-2/immunology ; Takotsubo Cardiomyopathy/diagnosis ; Takotsubo Cardiomyopathy/immunology ; Takotsubo Cardiomyopathy/pathology
Czasopismo naukowe
Tytuł :
Single-cell transcriptome profiling reveals molecular heterogeneity in human umbilical cord tissue and culture-expanded mesenchymal stem cells.
Autorzy :
Wang Q; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.; BGI-Shenzhen, China.; Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics, BGI-Shenzhen, China.
Li J; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.; BGI-Shenzhen, China.
Wang S; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.; BGI-Shenzhen, China.
Deng Q; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.; BGI-Shenzhen, China.
Wang K; BGI-Shenzhen, China.; Shenzhen BGI Cell Technology Co., Ltd, China.
Dai X; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.; BGI-Shenzhen, China.
An Y; BGI-Shenzhen, China.
Dong G; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.; BGI-Shenzhen, China.
Ke W; Department of Obstetrics, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, China.
Chen F; BGI-Shenzhen, China.; MGI, BGI-Shenzhen, China.
Liu L; BGI-Shenzhen, China.
Yang H; BGI-Shenzhen, China.; James D. Watson Institute of Genome Sciences, Hangzhou, China.
Du Y; BGI-Shenzhen, China.
Zhao W; Department of Obstetrics, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, China.
Shang Z; BGI-Shenzhen, China.; Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics, BGI-Shenzhen, China.; MGI, BGI-Shenzhen, China.; BGI College, Northwest University, Xi'an, China.
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Źródło :
The FEBS journal [FEBS J] 2021 Sep; Vol. 288 (18), pp. 5311-5330. Date of Electronic Publication: 2021 May 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Heterogeneity*
Mesenchymal Stem Cells/*metabolism
Transcriptome/*genetics
Umbilical Cord/*metabolism
Cell Differentiation/genetics ; Cells, Cultured ; Gene Expression Profiling ; Gene Expression Regulation/genetics ; Humans ; Mesenchymal Stem Cell Transplantation ; Single-Cell Analysis ; Umbilical Cord/cytology
Czasopismo naukowe
Tytuł :
Measuring expression heterogeneity of single-cell cytoskeletal protein complexes.
Autorzy :
Vlassakis J; Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA.
Hansen LL; Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA.
Higuchi-Sanabria R; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Zhou Y; Division of Biostatistics, University of California Berkeley, Berkeley, CA, USA.
Tsui CK; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Dillin A; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA, USA.
Huang H; Department of Statistics, University of California Berkeley, Berkeley, CA, USA.; Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA.
Herr AE; Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 17; Vol. 12 (1), pp. 4969. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genetic Heterogeneity*
Cytoskeletal Proteins/*genetics
Cytoskeletal Proteins/*metabolism
Cytoskeleton/*metabolism
Actins/genetics ; Actins/metabolism ; Animals ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Differentiation ; Cell Line ; Heat-Shock Response ; Humans ; Microtubules/metabolism ; Models, Biological ; Single-Cell Analysis/methods ; Thiazolidines/pharmacology
Czasopismo naukowe
Tytuł :
Genome sequencing in families with congenital limb malformations.
Autorzy :
Elsner J; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Mensah MA; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Holtgrewe M; Core Unit Bioinformatics, Berlin Institute of Health (BIH), Berlin, Germany.
Hertzberg J; Max Planck Institute for Molecular Genetics, RG Development and Disease, Berlin, Germany.
Bigoni S; Medical Genetics Unit, Department of Mother and Child, Ferrara Sant'Anna University Hospital, Ferrara, Italy.
Busche A; Institut Für Humangenetik, Universitätsklinikum Münster, Münster, Germany.
Coutelier M; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Human Genetics, Faculty of Medicine, Jewish General Hospital, McGill University, Montreal, QC, Canada.
de Silva DC; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Elçioglu N; Department of Pediatric Genetics, Marmara University Medical School, Istanbul, Turkey.; Eastern Mediterranean University Medical School, Cyprus, Mersin 10, Turkey.
Filges I; Institut für Medizinische Genetik und Pathologie, Universitätsspital Basel, Basel, Switzerland.
Gerkes E; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Girisha KM; Department of Medical Genetics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Graul-Neumann L; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Jamsheer A; Department of Medical Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Krawitz P; Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany.
Kurth I; Institute of Human Genetics, Medical Faculty, RWTH Aachen University Hospital, Aachen, Germany.
Markus S; Fachärztin Für Humangenetik, Bischof-von-Henle-Straße 2a, Regensburg, Germany.
Megarbane A; Department of Human Genetics, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon.
Reis A; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Reuter MS; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Svoboda D; Kinderhandchirurgie, Medizinische Fakultät Mannheim der Universität Heidelberg, Heidelberg, Germany.
Teller C; Synlab MVZ Bad Nauheim, Mondorfstr. 1761231, Bad Nauheim, Germany.
Tuysuz B; Department of Pediatric Genetics, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Türkmen S; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center of Genetics (NCG), Laboratoire National de Santé 1, Rue Louis Rech, 3555, Dudelange, Luxembourg.
Wilson M; Genetic Medicine, Children's Hospital at Westmead, Paediatrics and Child Health, Sydney, Australia.
Woitschach R; Institute of Human Genetics, University Medical Center Hamburg, Eppendorf, Germany.
Vater I; Institute of Human Genetics, University of Kiel, Kiel, Germany.
Caliebe A; Institute of Human Genetics, University of Kiel, Kiel, Germany.
Hülsemann W; Katholisches Kinderkrankenhaus Wilhelmstift, Hamburg, Germany.
Horn D; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Mundlos S; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. .; Max Planck Institute for Molecular Genetics, RG Development and Disease, Berlin, Germany. .
Spielmann M; Max Planck Institute for Molecular Genetics, RG Development and Disease, Berlin, Germany. .; Institute of Human Genetics, University of Kiel, Kiel, Germany. .; Institute of Human Genetics, University of Lübeck, Lübeck, Germany. .
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Źródło :
Human genetics [Hum Genet] 2021 Aug; Vol. 140 (8), pp. 1229-1239. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Heterogeneity*
Mutation*
Homeodomain Proteins/*genetics
Limb Deformities, Congenital/*genetics
Transcription Factors/*genetics
Ubiquitin-Activating Enzymes/*genetics
Base Sequence ; Cohort Studies ; DNA Copy Number Variations ; Gene Expression ; Genetic Testing ; Humans ; Infant ; Limb Deformities, Congenital/metabolism ; Limb Deformities, Congenital/pathology ; Male ; Pedigree ; Transcription Factors/deficiency ; Ubiquitin-Activating Enzymes/deficiency ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Predictive significance of HER2 intratumoral heterogeneity, determined by simultaneous gene and protein analysis, for resistance to trastuzumab-based treatments for HER2-positive breast cancer.
Autorzy :
Horii R; Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan. .; Department of Pathology, Saitama Cancer Center, 780 Komuro, Ina, Kita-adachi-gun, Saitama, 362-0806, Japan. .
Nitta H; Roche Tissue Diagnostics, Tucson, AZ, USA.
Nojima M; Center for Translational Research, The Institute of Medical Science Hospital, The University of Tokyo, Tokyo, Japan.
Maruyama R; Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Ueno T; Breast Oncology Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Ito Y; Breast Oncology Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Ohno S; Breast Oncology Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Banks P; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kanda H; Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.; Department of Pathology, Saitama Cancer Center, 780 Komuro, Ina, Kita-adachi-gun, Saitama, 362-0806, Japan.
Akiyama F; Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Jul; Vol. 479 (1), pp. 13-21. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Heterogeneity*
Antineoplastic Agents, Immunological/*therapeutic use
Biomarkers, Tumor/*genetics
Breast Neoplasms/*drug therapy
Drug Resistance, Neoplasm/*genetics
Receptor, ErbB-2/*genetics
Trastuzumab/*therapeutic use
Adult ; Aged ; Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Gene Amplification ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Middle Aged ; Predictive Value of Tests ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/metabolism
Czasopismo naukowe
Tytuł :
A computational approach for detecting physiological homogeneity in the midst of genetic heterogeneity.
Autorzy :
Zhang P; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA. Electronic address: .
Cobat A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Lee YS; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
Wu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Bayrak CS; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Boccon-Gibod C; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
Matuozzo D; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Lorenzo L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Jain A; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Boucherit S; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Vallée L; Neuropediatric Department, Roger Salengro Hospital, Lille 59037, France.
Stüve B; Clinics of the City of Cologne gGmbH, Cologne 53323, Germany.
Chabrier S; CHU Saint-Étienne, French Centre for Pediatric Stroke, Saint-Étienne, France.
Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address: .
Abel L; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Zhang SY; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Itan Y; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
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Źródło :
American journal of human genetics [Am J Hum Genet] 2021 Jun 03; Vol. 108 (6), pp. 1012-1025. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Regulatory Networks*
Genetic Heterogeneity*
Genetic Predisposition to Disease*
Computational Biology/*methods
Encephalitis, Herpes Simplex/*genetics
Encephalitis, Herpes Simplex/*pathology
Fibroblasts/*immunology
Case-Control Studies ; Encephalitis, Herpes Simplex/immunology ; Fibroblasts/metabolism ; Humans ; Toll-Like Receptor 3/genetics ; Toll-Like Receptor 3/immunology ; Toll-Like Receptor 3/metabolism ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Global Distribution and Genetic Heterogeneity of Border Disease Virus.
Autorzy :
Righi C; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
Petrini S; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
Pierini I; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
Giammarioli M; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
De Mia GM; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
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Źródło :
Viruses [Viruses] 2021 May 21; Vol. 13 (6). Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Heterogeneity*
Genetic Variation*
Border Disease/*epidemiology
Border Disease/*virology
Border disease virus/*genetics
Animals ; Border disease virus/classification ; Genome, Viral ; Genomics/methods ; Genotype ; Geography, Medical ; Global Health ; Host Specificity ; Host-Pathogen Interactions ; Phylogeny ; Ruminants/virology
Czasopismo naukowe
Tytuł :
Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.
Autorzy :
Hendley AM; Diabetes Center, University of California, San Francisco, San Francisco, United States.; Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, United States.
Rao AA; CoLabs, University of California, San Francisco, San Francisco, United States.; Bakar ImmunoX Initiative, University of California, San Francisco, San Francisco, United States.
Leonhardt L; Diabetes Center, University of California, San Francisco, San Francisco, United States.
Ashe S; Diabetes Center, University of California, San Francisco, San Francisco, United States.
Smith JA; Diabetes Center, University of California, San Francisco, San Francisco, United States.
Giacometti S; Diabetes Center, University of California, San Francisco, San Francisco, United States.
Peng XL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, United States.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Jiang H; Division of Hematology and Oncology, Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, United States.
Berrios DI; Diabetes Center, University of California, San Francisco, San Francisco, United States.
Pawlak M; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, United States.
Li LY; Diabetes Center, University of California, San Francisco, San Francisco, United States.
Lee J; Diabetes Center, University of California, San Francisco, San Francisco, United States.
Collisson EA; Division of Hematology and Oncology, Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, United States.
Anderson MS; Diabetes Center, University of California, San Francisco, San Francisco, United States.
Fragiadakis GK; CoLabs, University of California, San Francisco, San Francisco, United States.; Bakar ImmunoX Initiative, University of California, San Francisco, San Francisco, United States.; Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, United States.
Yeh JJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, United States.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Ye CJ; Parker Institute for Cancer Immunotherapy, San Francisco, United States.
Kim GE; Department of Pathology, University of California, San Francisco, San Francisco, United States.
Weaver VM; Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, United States.
Hebrok M; Diabetes Center, University of California, San Francisco, San Francisco, United States.
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Źródło :
ELife [Elife] 2021 May 19; Vol. 10. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Profiling*
Genetic Heterogeneity*
Single-Cell Analysis*
Transcriptome*
Pancreatic Ducts/*cytology
Animals ; Cell Line ; Cell Separation ; DNA Damage ; Databases, Genetic ; Disease Models, Animal ; Epithelial-Mesenchymal Transition ; Female ; Geminin/genetics ; Geminin/metabolism ; Gene Expression Regulation, Developmental ; Humans ; Mice, Inbred C57BL ; Mice, Transgenic ; Morphogenesis ; Osteopontin/genetics ; Osteopontin/metabolism ; Pancreatic Ducts/metabolism ; Pancreatitis, Chronic/genetics ; Pancreatitis, Chronic/metabolism ; Pancreatitis, Chronic/pathology ; Phenotype ; RNA-Seq
Czasopismo naukowe
Tytuł :
Drivers of dynamic intratumor heterogeneity and phenotypic plasticity.
Autorzy :
Biswas A; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
De S; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 May 01; Vol. 320 (5), pp. C750-C760. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Cell Plasticity*
Genetic Heterogeneity*
Biomarkers, Tumor/*genetics
Neoplasms/*genetics
Neoplasms/*pathology
Animals ; Antineoplastic Agents/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Epigenesis, Genetic ; Genetic Predisposition to Disease ; Humans ; Mutation ; Neoplasms/drug therapy ; Phenotype ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Establishment and characterization of 38 novel patient-derived primary cancer cell lines using multi-region sampling revealing intra-tumor heterogeneity of gallbladder carcinoma.
Autorzy :
Feng F; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Cheng Q; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Li B; 3D Medicines Inc., Shanghai, 201114, China.
Liu C; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Wang H; 3D Medicines Inc., Shanghai, 201114, China.
Li B; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Xu X; 3D Medicines Inc., Shanghai, 201114, China.
Yu Y; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Chen Z; 3D Medicines Inc., Shanghai, 201114, China.
Wu X; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Dong H; 3D Medicines Inc., Shanghai, 201114, China.
Chu K; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Xie Z; 3D Medicines Inc., Shanghai, 201114, China.
Gao Q; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Xiong L; 3D Medicines Inc., Shanghai, 201114, China.
Li F; 3D Medicines Inc., Shanghai, 201114, China.
Yi B; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Zhang D; 3D Medicines Inc., Shanghai, 201114, China. .
Jiang X; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China. .
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Źródło :
Human cell [Hum Cell] 2021 May; Vol. 34 (3), pp. 918-931. Date of Electronic Publication: 2021 Apr 04.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Heterogeneity*
Carcinoma/*genetics
Carcinoma/*pathology
Gallbladder Neoplasms/*genetics
Gallbladder Neoplasms/*pathology
Carcinogenesis/genetics ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; DNA-Binding Proteins/genetics ; Disease Progression ; Gene Expression Regulation, Neoplastic/genetics ; Genes, MHC Class I ; Genes, MHC Class II ; Humans ; Mutation ; Nuclear Proteins/physiology ; Trans-Activators/physiology ; Transcription Factors/genetics ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers.
Autorzy :
Nazarian A; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.
Kulminski AM; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.
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Źródło :
Genes [Genes (Basel)] 2021 May 01; Vol. 12 (5). Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genetic Heterogeneity*
Polymorphism, Single Nucleotide*
Colorectal Neoplasms/*genetics
Lung Neoplasms/*genetics
Adult ; Aged ; Female ; Gene Frequency ; Humans ; Male ; Middle Aged ; Sex Factors
Czasopismo naukowe
Tytuł :
The intra-class heterogeneity of immunophenotyping and immune landscape in oesophageal cancer and clinical implications.
Autorzy :
Xie Y; Department of Thoracic Surgery, The People's Hospital of Gaozhou, Gaozhou, China.; Guangdong Esophageal Cancer Institute, Guangzhou, China.
Shi X; Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen Y; Department of Thoracic Surgery, The People's Hospital of Gaozhou, Gaozhou, China.; Guangdong Esophageal Cancer Institute, Guangzhou, China.
Wu B; Department of Thoracic Surgery, The People's Hospital of Gaozhou, Gaozhou, China.; Guangdong Esophageal Cancer Institute, Guangzhou, China.
Gong X; Department of Graduate School, Guangdong Medical University, Zhanjiang, China.
Lu W; Department of Graduate School, Guangdong Medical University, Zhanjiang, China.
Lin W; Department of Thoracic Surgery, The People's Hospital of Gaozhou, Gaozhou, China.; Guangdong Esophageal Cancer Institute, Guangzhou, China.
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Źródło :
Annals of medicine [Ann Med] 2021 Dec; Vol. 53 (1), pp. 626-638.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Heterogeneity*
Adenocarcinoma/*immunology
Carcinoma, Squamous Cell/*immunology
Esophageal Neoplasms/*immunology
Tumor Microenvironment/*immunology
Adenocarcinoma/genetics ; Adenocarcinoma/mortality ; Antineoplastic Agents, Immunological/therapeutic use ; Biomarkers, Tumor/immunology ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/mortality ; Cluster Analysis ; Databases, Factual ; Drug Monitoring ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/mortality ; Humans ; Immunophenotyping ; Immunotherapy ; Predictive Value of Tests ; Prognosis ; Survival Analysis
SCR Disease Name :
Adenocarcinoma Of Esophagus
Czasopismo naukowe
Tytuł :
Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma.
Autorzy :
Sun YF; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Wu L; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; BGI Education Center, University of Chinese Academy of Sciences (UCAS), Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Liu SP; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Jiang MM; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; State Key Laboratory of Bioelectronics, Southeast University, Nanjing, China.; School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Hu B; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Zhou KQ; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Guo W; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Xu Y; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Zhong Y; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Zhou XR; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; BGI Education Center, University of Chinese Academy of Sciences (UCAS), Shenzhen, China.
Zhang ZF; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Liu G; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.
Liu S; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; BGI Education Center, University of Chinese Academy of Sciences (UCAS), Shenzhen, China.
Shi YH; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Ji Y; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Du M; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Li NN; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Li GB; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Zhao ZK; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.
Huang XY; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.
Xu LQ; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Yu QC; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Peng DH; Dunwill Med-Tech, Shanghai, China.
Qiu SJ; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Sun HC; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Dean M; Laboratory of Translational Genomics, Division of Cancer Epidemiology & Genetics, National Cancer Institute Gaithersburg, Rockville, MD, USA.
Wang XD; Zhongshan Hospital Institute of Clinical Science, Shanghai Institute of Clinical Bioinformatics, Fudan University Center for Clinical Bioinformatics, Shanghai, China.
Chung WY; Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Dennison AR; Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Zhou J; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.; Zhong-Hua Precision Medical Center, Zhongshan Hospital, Fudan University-BGI, Shanghai, People's Republic of China.
Hou Y; Zhong-Hua Precision Medical Center, Zhongshan Hospital, Fudan University-BGI, Shanghai, People's Republic of China. .
Fan J; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China. .; Zhong-Hua Precision Medical Center, Zhongshan Hospital, Fudan University-BGI, Shanghai, People's Republic of China. .
Yang XR; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 02; Vol. 12 (1), pp. 4091. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Heterogeneity*
Immune Evasion*
Carcinoma, Hepatocellular/*genetics
Carcinoma, Hepatocellular/*immunology
Liver Neoplasms/*genetics
Liver Neoplasms/*immunology
Neoplastic Cells, Circulating/*immunology
Aged ; Animals ; Biomarkers, Tumor/metabolism ; Cell Cycle ; Cell Line, Tumor ; Chemokine CCL5/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Neoplasm Metastasis ; Neoplastic Cells, Circulating/metabolism ; Prognosis ; RNA-Seq ; Transcriptome ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Heterogeneity of congenital afibrinogenemia, from epidemiology to clinical consequences and management.
Autorzy :
Casini A; Division of Angiology and Hemostasis, University Hospitals of Geneva, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland. Electronic address: .
Neerman-Arbez M; Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, 1 Rue Michel Servet, 1211 Geneva, Switzerland. Electronic address: .
de Moerloose P; Faculty of Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland. Electronic address: .
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Źródło :
Blood reviews [Blood Rev] 2021 Jul; Vol. 48, pp. 100793. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genetic Heterogeneity*
Afibrinogenemia/*epidemiology
Afibrinogenemia/*etiology
Genetic Diseases, Inborn/*epidemiology
Afibrinogenemia/diagnosis ; Afibrinogenemia/therapy ; Animals ; Disease Management ; Disease Susceptibility ; Genetic Diseases, Inborn/diagnosis ; Genetic Diseases, Inborn/therapy ; Hemorrhage/diagnosis ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Hemorrhage/therapy ; Humans ; Public Health Surveillance ; Thrombosis/diagnosis ; Thrombosis/epidemiology ; Thrombosis/etiology
Czasopismo naukowe
Tytuł :
Deciphering transcriptional and functional heterogeneity in hematopoiesis with single-cell genomics.
Autorzy :
Martin-Rufino JD; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard.
Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
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Źródło :
Current opinion in hematology [Curr Opin Hematol] 2021 Jul 01; Vol. 28 (4), pp. 269-276.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Gene Expression Regulation, Developmental*
Genetic Heterogeneity*
Genomics*/methods
Single-Cell Analysis*/methods
Cell Differentiation/*genetics
Hematopoiesis/*genetics
Hematopoietic Stem Cells/*metabolism
Animals ; Gene Expression Profiling/methods ; Hematopoietic Stem Cells/cytology ; Humans ; In Situ Hybridization, Fluorescence ; Transcriptome
Czasopismo naukowe
Tytuł :
An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability.
Autorzy :
Hayford CE; Chemical and Physical Biology Graduate Program, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Tyson DR; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Robbins CJ 3rd; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Frick PL; Chemical and Physical Biology Graduate Program, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Quaranta V; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Harris LA; Department of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, United States of America.; Interdisciplinary Graduate Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas, United States of America.; Cancer Biology Program, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.
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Źródło :
PLoS biology [PLoS Biol] 2021 Jun 01; Vol. 19 (6), pp. e3000797. Date of Electronic Publication: 2021 Jun 01 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*/drug effects
Genetic Heterogeneity*/drug effects
Models, Biological*
Neoplasms/*genetics
Neoplasms/*pathology
Antineoplastic Agents/pharmacology ; Cell Death/drug effects ; Cell Line, Tumor ; Computer Simulation ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/drug effects ; Genome, Human ; Humans ; Phenotype ; Stochastic Processes ; Transcriptome/drug effects ; Transcriptome/genetics
Czasopismo naukowe

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