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Tytuł:
Exosomes secreted by Fusobacterium nucleatum-infected colon cancer cells transmit resistance to oxaliplatin and 5-FU by delivering hsa_circ_0004085.
Autorzy:
Hui B; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.
Zhou C; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.
Xu Y; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Wang R; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.
Dong Y; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.
Zhou Y; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.
Ding J; Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Zhang X; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. .; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China. .
Xu J; Department of General Surgery, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. .
Gu Y; Department of Oncology and Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. .; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2024 Feb 15; Vol. 22 (1), pp. 62. Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/metabolism
Exosomes*/metabolism
Heterogeneous-Nuclear Ribonucleoprotein L*/metabolism
Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/metabolism
MicroRNAs*/metabolism
Humans ; Oxaliplatin/pharmacology ; Oxaliplatin/therapeutic use ; Oxaliplatin/metabolism ; Fusobacterium nucleatum/genetics ; Fusobacterium nucleatum/metabolism ; Heterogeneous Nuclear Ribonucleoprotein A1/metabolism ; Chromatography, Liquid ; Endoplasmic Reticulum Chaperone BiP ; Tandem Mass Spectrometry ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Cell Proliferation
Czasopismo naukowe
Tytuł:
hnRNPA1 impedes snakehead vesiculovirus replication via competitively disrupting viral phosphoprotein-nucleoprotein interaction and degrading viral phosphoprotein.
Autorzy:
Liu AQ; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries, Huazhong Agricultural University, Wuhan, China.
Qin X; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries, Huazhong Agricultural University, Wuhan, China.
Wu H; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha, China.
Feng H; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha, China.
Zhang YA; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries, Huazhong Agricultural University, Wuhan, China.
Tu J; State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries, Huazhong Agricultural University, Wuhan, China.
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Źródło:
Virulence [Virulence] 2023 Dec; Vol. 14 (1), pp. 2196847.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Nucleoproteins*/metabolism
Rhabdoviridae Infections*/metabolism
Animals ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Fishes ; Vesiculovirus/genetics ; Vesiculovirus/metabolism ; Phosphoproteins/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł:
Heterogeneous Ribonucleoprotein A1 (hnRNPA1) Interacts with the Nucleoprotein of the Influenza a Virus and Impedes Virus Replication.
Autorzy:
Kaur R; School of Science, Monash University, Selangor 47500, Malaysia.
Batra J; School of Science, Monash University, Selangor 47500, Malaysia.
Stuchlik O; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Reed MS; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Pohl J; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Sambhara S; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Lal SK; School of Science, Monash University, Selangor 47500, Malaysia.; Tropical Medicine & Biology Platform, Monash University, Selangor 47500, Malaysia.
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Źródło:
Viruses [Viruses] 2022 Jan 20; Vol. 14 (2). Date of Electronic Publication: 2022 Jan 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism
Influenza A Virus, H1N1 Subtype/*metabolism
Influenza, Human/*metabolism
Nucleocapsid Proteins/*metabolism
A549 Cells ; HEK293 Cells ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Host-Pathogen Interactions ; Humans ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza, Human/genetics ; Influenza, Human/virology ; Nucleocapsid Proteins/genetics ; Protein Binding ; Virus Replication
Czasopismo naukowe
Tytuł:
Celastrol alleviates comorbid obesity and depression by directly binding amygdala HnRNPA1 in a mouse model.
Autorzy:
Zhu C; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Yang J; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Zhu Y; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Li J; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Chi H; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Tian C; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Meng Y; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Liu Y; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Wang J; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.; Shenzhen People's Hospital, Shenzhen, China.; Central People's Hospital of Zhanjiang, Zhanjiang, China.
Lin N; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2021 Jun; Vol. 11 (6), pp. e394.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Disease Models, Animal*
Amygdala/*metabolism
Depression/*drug therapy
Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism
Obesity/*drug therapy
Pentacyclic Triterpenes/*pharmacology
Animals ; Comorbidity ; Depression/complications ; Depression/metabolism ; Depression/pathology ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Mice ; Obesity/complications ; Obesity/metabolism ; Obesity/pathology
Raport
Tytuł:
HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation.
Autorzy:
Ryu HG; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Jung Y; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Lee N; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01065, USA.
Seo JY; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Kim SW; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Lee KH; Division of Cosmetic Science and Technology, Daegu Haany University, Gyeongsan 38610, Korea.
Kim DY; Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea.
Kim KT; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 May 23; Vol. 22 (11). Date of Electronic Publication: 2021 May 23.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Biosynthesis*
Heterogeneous Nuclear Ribonucleoprotein A1/*physiology
Intracellular Signaling Peptides and Proteins/*genetics
Lung Neoplasms/*pathology
Neoplasm Proteins/*physiology
Protein Serine-Threonine Kinases/*genetics
3' Untranslated Regions ; Base Sequence ; CRISPR-Cas Systems ; Cell Cycle ; Cell Line ; Cyclin D1/biosynthesis ; Cyclin D1/genetics ; Eukaryotic Initiation Factor-3/metabolism ; Gene Expression Regulation, Neoplastic ; Genes, Reporter ; Heterogeneous Nuclear Ribonucleoprotein A1/chemistry ; Humans ; Intracellular Signaling Peptides and Proteins/biosynthesis ; Lung Neoplasms/genetics ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Protein Binding ; Protein Domains ; Protein Interaction Mapping ; Protein Serine-Threonine Kinases/biosynthesis ; RNA Interference ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Recombinant Proteins/metabolism ; Sequence Deletion ; Up-Regulation
Czasopismo naukowe
Tytuł:
ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation.
Autorzy:
Zhu HE; Department of General Practice, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510150, P.R. China.
Li T; Department of Anesthesiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510150, P.R. China.
Shi S; State Key Laboratory of Animal Breeding, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, South China Key Laboratory of Animal Nutrition and Feed, Ministry of Agriculture, Guangzhou, 510640, P. R. China.
Chen DX; Department of General Practice, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510150, P.R. China.
Chen W; Department of Respiratory, The People's Hospital of Qingyuan, Sixth Affiliate Hospital of Guangzhou Medical University, Qingyuan, 511518, P. R. China. .
Chen H; Department of Pathology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510150, P.R. China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2021 Feb 11; Vol. 40 (1), pp. 64. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji:
Journal Article
MeSH Terms:
Acetyltransferases/*metabolism
Adenocarcinoma of Lung/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism
Lung Neoplasms/*metabolism
Acetylation ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Animals ; Cell Line, Tumor ; Disease Progression ; HEK293 Cells ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred NOD ; Middle Aged ; Transfection
Czasopismo naukowe
Tytuł:
Role of Heterogeneous Nuclear Ribonucleoproteins in the Cancer-Immune Landscape.
Autorzy:
Sudhakaran M; Molecular, Cellular, and Integrative Physiology Graduate Program, Michigan State University, East Lansing, MI 48824, USA.; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Doseff AI; Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 07; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Heterogeneous-Nuclear Ribonucleoproteins*/genetics
Heterogeneous-Nuclear Ribonucleoproteins*/metabolism
Neoplasms*/genetics
Humans ; RNA-Binding Proteins/metabolism ; Alternative Splicing ; Transcription Factors/metabolism ; Heterogeneous Nuclear Ribonucleoprotein A1/metabolism
Czasopismo naukowe
Tytuł:
Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues.
Autorzy:
Noto PB; Experimental Medicine Unit, Oncology R&D, GSK, Collegeville, USA. .
Sikorski TW; Protein Mass Spectrometry, In Vitro/In Vivo Translation, Research, GSK, Collegeville, USA.
Zappacosta F; Discovery Analytical, Medicinal Science and Technology, Research, GSK, Collegeville, USA.
Wagner CD; Discovery Analytical, Medicinal Science and Technology, Research, GSK, Collegeville, USA.
Montes de Oca R; Experimental Medicine Unit, Oncology R&D, GSK, Collegeville, USA.
Szapacs ME; Protein Mass Spectrometry, In Vitro/In Vivo Translation, Research, GSK, Collegeville, USA.
Annan RS; Discovery Analytical, Medicinal Science and Technology, Research, GSK, Collegeville, USA.
Liu Y; Epigenetics, Oncology R&D, GSK, Collegeville, USA.
McHugh CF; Discovery DMPK, In Vitro / In Vivo Translation, Research, GSK, Collegeville, USA.
Mohammad HP; Epigenetics, Oncology R&D, GSK, Collegeville, USA.
Piccoli SP; Experimental Medicine Unit, Oncology R&D, GSK, Collegeville, USA.; Clinical Biomarkers and Diagnostics, Sun Pharmaceutical Advanced Research Center (SPARC), Princeton, USA.
Creasy CL; Epigenetics, Oncology R&D, GSK, Collegeville, USA.
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Źródło:
Scientific reports [Sci Rep] 2020 Dec 17; Vol. 10 (1), pp. 22155. Date of Electronic Publication: 2020 Dec 17.
Typ publikacji:
Journal Article
MeSH Terms:
Biomarkers*
Antineoplastic Agents/*pharmacokinetics
Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism
Protein-Arginine N-Methyltransferases/*antagonists & inhibitors
Repressor Proteins/*antagonists & inhibitors
Animals ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents, Immunological/chemistry ; Antineoplastic Agents, Immunological/pharmacokinetics ; Antineoplastic Agents, Immunological/pharmacology ; Arginine/metabolism ; Cells, Cultured ; Chromatography, Liquid ; Drug Monitoring ; Enzyme Activation ; Enzyme Inhibitors/pharmacokinetics ; Enzyme Inhibitors/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects ; Heterogeneous Nuclear Ribonucleoprotein A1/blood ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Mass Spectrometry ; Methylation ; Mice ; Molecular Targeted Therapy ; Neoplasms/blood ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Protein-Arginine N-Methyltransferases/genetics ; Repressor Proteins/genetics ; Substrate Specificity
Czasopismo naukowe
Tytuł:
Monoclonal antibody against H1N1 influenza virus hemagglutinin cross reacts with hnRNPA1 and hnRNPA2/B1.
Autorzy:
Guo C; Central Laboratory of Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Medical School, Xi'an Jiaotong University, Shaanxi Province Research Centre of Cell Immunological Engineering and Technology, Key Laboratory of Microbial Infections and Autoimmune Diseases, Xi'an, Shaanxi 710068, P.R. China.
Sun L; Central Laboratory of Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Medical School, Xi'an Jiaotong University, Shaanxi Province Research Centre of Cell Immunological Engineering and Technology, Key Laboratory of Microbial Infections and Autoimmune Diseases, Xi'an, Shaanxi 710068, P.R. China.
Hao S; Guangshui Traditional Chinese Medicine Hospital of Hubei Province, Guangshui, Hubei 432700, P.R. China.
Huang X; Central Laboratory of Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Medical School, Xi'an Jiaotong University, Shaanxi Province Research Centre of Cell Immunological Engineering and Technology, Key Laboratory of Microbial Infections and Autoimmune Diseases, Xi'an, Shaanxi 710068, P.R. China.
Hu H; School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.
Liang D; Central Laboratory of Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Medical School, Xi'an Jiaotong University, Shaanxi Province Research Centre of Cell Immunological Engineering and Technology, Key Laboratory of Microbial Infections and Autoimmune Diseases, Xi'an, Shaanxi 710068, P.R. China.
Feng Q; Central Laboratory of Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Medical School, Xi'an Jiaotong University, Shaanxi Province Research Centre of Cell Immunological Engineering and Technology, Key Laboratory of Microbial Infections and Autoimmune Diseases, Xi'an, Shaanxi 710068, P.R. China.
Li Y; Central Laboratory of Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Medical School, Xi'an Jiaotong University, Shaanxi Province Research Centre of Cell Immunological Engineering and Technology, Key Laboratory of Microbial Infections and Autoimmune Diseases, Xi'an, Shaanxi 710068, P.R. China.
Feng Y; Central Laboratory of Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Medical School, Xi'an Jiaotong University, Shaanxi Province Research Centre of Cell Immunological Engineering and Technology, Key Laboratory of Microbial Infections and Autoimmune Diseases, Xi'an, Shaanxi 710068, P.R. China.
Xie X; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, P.R. China.
Hu J; Central Laboratory of Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Medical School, Xi'an Jiaotong University, Shaanxi Province Research Centre of Cell Immunological Engineering and Technology, Key Laboratory of Microbial Infections and Autoimmune Diseases, Xi'an, Shaanxi 710068, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2020 Nov; Vol. 22 (5), pp. 3969-3975. Date of Electronic Publication: 2020 Sep 07.
Typ publikacji:
Journal Article
MeSH Terms:
Antibodies, Monoclonal/*metabolism
Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group A-B/*metabolism
Influenza A Virus, H1N1 Subtype/*immunology
Animals ; Brain/metabolism ; Hemagglutinins/immunology ; Heterogeneous Nuclear Ribonucleoprotein A1/chemistry ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/chemistry ; Influenza Vaccines/metabolism ; Male ; Protein Domains ; Rats
Czasopismo naukowe
Tytuł:
Repurposing Potential of Riluzole as an ITAF Inhibitor in mTOR Therapy Resistant Glioblastoma.
Autorzy:
Benavides-Serrato A; Department of Research & Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA 91343, USA.
Saunders JT; Department of Research & Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA 91343, USA.
Holmes B; Department of Research & Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA 91343, USA.
Nishimura RN; Department of Research & Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA 91343, USA.; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Lichtenstein A; Department of Research & Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA 91343, USA.; Jonnson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA 90095, USA.; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Gera J; Department of Research & Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA 91343, USA.; Jonnson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA 90095, USA.; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.; Molecular Biology Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 05; Vol. 21 (1). Date of Electronic Publication: 2020 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Glioblastoma/*metabolism
Heterogeneous Nuclear Ribonucleoprotein A1/*antagonists & inhibitors
Internal Ribosome Entry Sites/*drug effects
Riluzole/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Repositioning ; Drug Resistance, Neoplasm ; Drug Synergism ; Female ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Heterogeneous Nuclear Ribonucleoprotein A1/metabolism ; Humans ; Internal Ribosome Entry Sites/physiology ; Mice ; Mice, SCID ; Molecular Docking Simulation ; Protein Biosynthesis/drug effects ; Riluzole/chemistry ; Riluzole/therapeutic use ; TOR Serine-Threonine Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł:
HnRNP A1 - mediated alternative splicing of CCDC50 contributes to cancer progression of clear cell renal cell carcinoma via ZNF395.
Autorzy:
Sun G; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China.; Hubei Institute of Urology, Wuhan, 430030, P.R. China.
Zhou H; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China.; Hubei Institute of Urology, Wuhan, 430030, P.R. China.
Chen K; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China.; Hubei Institute of Urology, Wuhan, 430030, P.R. China.
Zeng J; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China.; Hubei Institute of Urology, Wuhan, 430030, P.R. China.
Zhang Y; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China.; Hubei Institute of Urology, Wuhan, 430030, P.R. China.
Yan L; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China.; Hubei Institute of Urology, Wuhan, 430030, P.R. China.
Yao W; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China.; Hubei Institute of Urology, Wuhan, 430030, P.R. China.
Hu J; Hubei Institute of Urology, Wuhan, 430030, P.R. China.; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Wang T; Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, 361000, P.R. China.
Xing J; Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, 361000, P.R. China.
Xiao K; Department of Urology, The People's Hospital of Shenzhen City, Shenzhen, 518000, P.R. China.
Wu L; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Ye Z; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China.; Hubei Institute of Urology, Wuhan, 430030, P.R. China.
Xu H; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, P.R. China. .; Hubei Institute of Urology, Wuhan, 430030, P.R. China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2020 Jun 19; Vol. 39 (1), pp. 116. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji:
Journal Article; Retracted Publication
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Carcinoma, Renal Cell/*pathology
DNA-Binding Proteins/*metabolism
Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism
Intracellular Signaling Peptides and Proteins/*genetics
Kidney Neoplasms/*pathology
Transcription Factors/*metabolism
Alternative Splicing ; Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Cell Proliferation ; DNA-Binding Proteins/genetics ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Humans ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Mice ; Prognosis ; RNA Splicing ; Survival Rate ; Transcription Factors/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1-related spectrum.
Autorzy:
Han X; Department of Neurology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Zhan F; Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200233, Shanghai, China.
Yao Y; Department of Neurology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Cao L; Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200233, Shanghai, China.
Liu J; Department of Neurology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Yao S; Department of Neurology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
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Źródło:
Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2022 Dec; Vol. 9 (12), pp. 1910-1917. Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Heterogeneous-Nuclear Ribonucleoprotein Group A-B*/genetics
Heterogeneous-Nuclear Ribonucleoprotein Group A-B*/metabolism
Amyotrophic Lateral Sclerosis*/metabolism
Humans ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Mutation ; Exome Sequencing
Czasopismo naukowe
Tytuł:
RP11-81H3.2 promotes gastric cancer progression through miR-339-HNRNPA1 interaction network.
Autorzy:
Chen FR; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Sha SM; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wang SH; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Shi HT; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Dong L; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Liu D; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Cheng Y; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
An M; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wang Y; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Zhang J; Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
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Źródło:
Cancer medicine [Cancer Med] 2020 Apr; Vol. 9 (7), pp. 2524-2534. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
Stomach Neoplasms/*pathology
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; Female ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/metabolism ; Middle Aged ; Prognosis ; Protein Interaction Domains and Motifs ; RNA, Long Noncoding/metabolism ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation.
Autorzy:
Li ML; Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, United States of America.
Lin JY; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chen BS; Research Center for Emerging Viral Infections, Chang Gung University, Tao-Yuan, Taiwan.
Weng KF; Research Center for Emerging Viral Infections, Chang Gung University, Tao-Yuan, Taiwan.
Shih SR; Research Center for Emerging Viral Infections, Chang Gung University, Tao-Yuan, Taiwan.; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Tao-Yuan, Taiwan.
Calderon JD; Department of Chemistry, Case Western Reserve University, Cleveland, OH, United States of America.
Tolbert BS; Department of Chemistry, Case Western Reserve University, Cleveland, OH, United States of America.
Brewer G; Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Sep 09; Vol. 14 (9), pp. e0221048. Date of Electronic Publication: 2019 Sep 09 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Biosynthesis*
Apoptotic Protease-Activating Factor 1/*genetics
Caspase 3/*genetics
Cysteine Endopeptidases/*genetics
Enterovirus A, Human/*genetics
Heterogeneous Nuclear Ribonucleoprotein A1/*genetics
Viral Proteins/*genetics
3C Viral Proteases ; Animals ; Apoptosis/genetics ; Apoptotic Protease-Activating Factor 1/metabolism ; Caspase 3/metabolism ; Cell Line, Tumor ; Chlorocebus aethiops ; Cysteine Endopeptidases/metabolism ; Enterovirus A, Human/metabolism ; Gene Expression Regulation ; Heterogeneous Nuclear Ribonucleoprotein A1/metabolism ; Host-Pathogen Interactions/genetics ; Humans ; Internal Ribosome Entry Sites ; Muscle Cells/metabolism ; Muscle Cells/virology ; Neuroglia/metabolism ; Neuroglia/virology ; Protein Binding ; Proteolysis ; Signal Transduction ; Vero Cells ; Viral Proteins/metabolism
Czasopismo naukowe
Tytuł:
Tumor-Promoting Actions of HNRNP A1 in HCC Are Associated with Cell Cycle, Mitochondrial Dynamics, and Necroptosis.
Autorzy:
Zhao B; Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Lv X; Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Zhao X; Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Maimaitiaili S; Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Zhang Y; Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Su K; Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Yu H; Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.; Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China.
Liu C; Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Qiao T; Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 06; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 06.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/metabolism
Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism
Animals ; Cell Cycle ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Humans ; Mice ; Mitochondrial Dynamics ; Necroptosis ; Ribonucleoproteins
Czasopismo naukowe
Tytuł:
Optimization of Bifunctional Antisense Oligonucleotides for Regulation of Mutually Exclusive Alternative Splicing of PKM Gene.
Autorzy:
Bartyś N; Department of Nucleic Acids Bioengineering, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Pasternak A; Department of Nucleic Acids Bioengineering, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Lisowiec-Wąchnicka J; Department of Nucleic Acids Bioengineering, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Sep 03; Vol. 27 (17). Date of Electronic Publication: 2022 Sep 03.
Typ publikacji:
Journal Article
MeSH Terms:
Alternative Splicing*/genetics
Oligonucleotides, Antisense*/genetics
Exons ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; RNA Splicing
Czasopismo naukowe
Tytuł:
miR-128 Restriction of LINE-1 (L1) Retrotransposition Is Dependent on Targeting hnRNPA1 mRNA.
Autorzy:
Fung L; Department of Molecular Biology and Biochemistry, Francisco J. AyalaSchool of Biological Sciences, University of California, Irvine, CA 92697, USA. .
Guzman H; Department of Molecular Biology and Biochemistry, Francisco J. AyalaSchool of Biological Sciences, University of California, Irvine, CA 92697, USA. .
Sevrioukov E; Department of Molecular Biology and Biochemistry, Francisco J. AyalaSchool of Biological Sciences, University of California, Irvine, CA 92697, USA. .
Idica A; Department of Molecular Biology and Biochemistry, Francisco J. AyalaSchool of Biological Sciences, University of California, Irvine, CA 92697, USA. .
Park E; Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA. .
Bochnakian A; Department of Molecular Biology and Biochemistry, Francisco J. AyalaSchool of Biological Sciences, University of California, Irvine, CA 92697, USA. .
Daugaard I; Department of Molecular Biology and Biochemistry, Francisco J. AyalaSchool of Biological Sciences, University of California, Irvine, CA 92697, USA. .
Jury D; Department of Molecular Biology and Biochemistry, Francisco J. AyalaSchool of Biological Sciences, University of California, Irvine, CA 92697, USA. .
Mortazavi A; Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA. .
Zisoulis DG; Department of Molecular Biology and Biochemistry, Francisco J. AyalaSchool of Biological Sciences, University of California, Irvine, CA 92697, USA. .
Pedersen IM; Department of Molecular Biology and Biochemistry, Francisco J. AyalaSchool of Biological Sciences, University of California, Irvine, CA 92697, USA. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Apr 21; Vol. 20 (8). Date of Electronic Publication: 2019 Apr 21.
Typ publikacji:
Journal Article
MeSH Terms:
Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism
Long Interspersed Nucleotide Elements/*genetics
MicroRNAs/*metabolism
RNA, Messenger/*metabolism
Antagomirs/metabolism ; Base Sequence ; HeLa Cells ; Heterogeneous Nuclear Ribonucleoprotein A1/antagonists & inhibitors ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Humans ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; Open Reading Frames/genetics ; RNA Interference ; RNA, Small Interfering/metabolism ; Sequence Alignment
Czasopismo naukowe
Tytuł:
Expression of HnRNP A1, ZEB1, and E-cadherin in Hepatocellular carcinoma and their impact on patients' prognosis and survival.
Autorzy:
Abouhashem NS; Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Elwan A; Department of Clinical Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
El Hefnawy AS; Department of Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Atwa HA; Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
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Źródło:
Indian journal of pathology & microbiology [Indian J Pathol Microbiol] 2022 Jul-Sep; Vol. 65 (3), pp. 589-597.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/diagnosis
Carcinoma, Hepatocellular*/genetics
Carcinoma, Hepatocellular*/metabolism
Liver Neoplasms*/diagnosis
Liver Neoplasms*/genetics
Liver Neoplasms*/metabolism
Cadherins/genetics ; Cadherins/metabolism ; Heterogeneous Nuclear Ribonucleoprotein A1/metabolism ; Humans ; Prognosis ; Retrospective Studies ; Zinc Finger E-box-Binding Homeobox 1/genetics ; Zinc Finger E-box-Binding Homeobox 1/metabolism
Czasopismo naukowe
Tytuł:
Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer.
Autorzy:
Carabet LA; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada. .
Leblanc E; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada. .
Lallous N; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada. .
Morin H; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada. .
Ghaidi F; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada. .
Lee J; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada. .
Rennie PS; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada. .
Cherkasov A; Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2019 Feb 20; Vol. 24 (4). Date of Electronic Publication: 2019 Feb 20.
Typ publikacji:
Journal Article
MeSH Terms:
Computational Biology*/methods
Drug Discovery*/methods
Gene Expression Regulation, Neoplastic/*drug effects
Heterogeneous Nuclear Ribonucleoprotein A1/*genetics
Prostatic Neoplasms, Castration-Resistant/*genetics
RNA Splicing/*drug effects
Binding Sites ; Cell Line, Tumor ; Computer Simulation ; Heterogeneous Nuclear Ribonucleoprotein A1/chemistry ; Humans ; Male ; Models, Molecular ; Molecular Conformation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Complex interaction between mutant HNRNPA1 and gE of varicella zoster virus in pathogenesis of multiple sclerosis.
Autorzy:
Kattimani Y; a Laboratory of Genomic Sciences, Department of Studies in Genetics and Genomics , University of Mysore , Mysore , Karnataka , India.
Veerappa AM; a Laboratory of Genomic Sciences, Department of Studies in Genetics and Genomics , University of Mysore , Mysore , Karnataka , India.
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Źródło:
Autoimmunity [Autoimmunity] 2018 Jun; Vol. 51 (4), pp. 147-151. Date of Electronic Publication: 2018 Jul 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Multiple Sclerosis*/genetics
Multiple Sclerosis*/immunology
Multiple Sclerosis*/pathology
Multiple Sclerosis*/virology
Mutation*
Central Nervous System/*immunology
Chickenpox/*immunology
Chickenpox/*virology
Herpesvirus 3, Human/*immunology
Heterogeneous Nuclear Ribonucleoprotein A1/*immunology
Viral Envelope Proteins/*immunology
Animals ; Antigens, Viral/immunology ; Apoptosis/genetics ; Apoptosis/immunology ; Autoantibodies/genetics ; Autoantibodies/immunology ; Axons/immunology ; Axons/pathology ; Central Nervous System/pathology ; Central Nervous System/virology ; Chickenpox/pathology ; Herpesvirus 3, Human/pathogenicity ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Histocompatibility Antigens Class I/immunology ; Humans ; Models, Immunological ; Molecular Mimicry/genetics ; Molecular Mimicry/immunology ; Myelin Sheath/immunology ; Myelin Sheath/pathology ; Myelin Sheath/virology ; Protein Domains ; Superantigens/genetics ; Superantigens/immunology
Czasopismo naukowe

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