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Wyszukujesz frazę ""High-Throughput Screening Assays"" wg kryterium: Temat


Tytuł :
A technology of a different sort: microraft arrays.
Autorzy :
Cortés-Llanos B; Department of Bioengineering, University of Washington, Seattle, WA, USA. .
Wang Y
Sims CE
Allbritton NL
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Źródło :
Lab on a chip [Lab Chip] 2021 Sep 07; Vol. 21 (17), pp. 3204-3218. Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
High-Throughput Screening Assays*
Technology*
Cell Movement ; Cell Separation ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
High-Throughput Affinity Selection Mass Spectrometry Using SAMDI-MS to Identify Small-Molecule Binders of the Human Rhinovirus 3C Protease.
Autorzy :
Scholle MD; SAMDI Tech, Inc., Chicago, IL, USA.
McLaughlin D; MoMa Therapeutics, Boston, MA, USA.
Gurard-Levin ZA; SAMDI Tech, Inc., Chicago, IL, USA.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Sep; Vol. 26 (8), pp. 974-983. Date of Electronic Publication: 2021 Jun 19.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
COVID-19/*drug therapy
Rhinovirus/*drug effects
Small Molecule Libraries/*chemistry
3C Viral Proteases/chemistry ; COVID-19/virology ; Drug Discovery ; Humans ; Ligands ; Mass Spectrometry ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; Small Molecule Libraries/isolation & purification ; Small Molecule Libraries/therapeutic use
Czasopismo naukowe
Tytuł :
High-throughput protein modification quantitation analysis using intact protein MRM and its application on hENGase inhibitor screening.
Autorzy :
Tao D; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA. Electronic address: .
Xu M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Farkhondeh A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Burns AP; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Rodems S; Traverse Therapeutics, San Diego, CA, 92130, USA.
Might M; University of Alabama at Birmingham, Birmingham, AL, 35210, USA.
Zheng W; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
LeClair CA; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA. Electronic address: .
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Źródło :
Talanta [Talanta] 2021 Aug 15; Vol. 231, pp. 122384. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Tandem Mass Spectrometry*
Humans
Czasopismo naukowe
Tytuł :
Acoustic Ejection Mass Spectrometry for High-Throughput Analysis.
Autorzy :
Zhang H; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
Liu C; SCIEX, 71 Four Valley Drive, Concord, Ontario L4K 4V8, Canada.
Hua W; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
Ghislain LP; Beckman Coulter Life Sciences Inc., San Jose, California 95134, United States.
Liu J; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
Aschenbrenner L; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
Noell S; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
Dirico KJ; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
Lanyon LF; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
Steppan CM; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
West M; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
Arnold DW; SCIEX, 71 Four Valley Drive, Concord, Ontario L4K 4V8, Canada.
Covey TR; SCIEX, 71 Four Valley Drive, Concord, Ontario L4K 4V8, Canada.
Datwani SS; Beckman Coulter Life Sciences Inc., San Jose, California 95134, United States.
Troutman MD; Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Aug 10; Vol. 93 (31), pp. 10850-10861. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Spectrometry, Mass, Electrospray Ionization*
Acoustics
Czasopismo naukowe
Tytuł :
High-throughput optofluidic screening for improved microbial cell factories via real-time micron-scale productivity monitoring.
Autorzy :
Rienzo M; Research and Development, Amyris, Inc., 5885 Hollis St., Suite 100, Emeryville, CA 94608, USA. .
Lin KC; Technology and Business Development, Berkeley Lights, Inc., 5858 Horton St., Unit 320, Emeryville, CA 94608, USA. .
Mobilia KC; Technology and Business Development, Berkeley Lights, Inc., 5858 Horton St., Unit 320, Emeryville, CA 94608, USA. .
Sackmann EK; Technology and Business Development, Berkeley Lights, Inc., 5858 Horton St., Unit 320, Emeryville, CA 94608, USA. .
Kurz V; Technology and Business Development, Berkeley Lights, Inc., 5858 Horton St., Unit 320, Emeryville, CA 94608, USA. .
Navidi AH; Research and Development, Amyris, Inc., 5885 Hollis St., Suite 100, Emeryville, CA 94608, USA. .
King J; Research and Development, Amyris, Inc., 5885 Hollis St., Suite 100, Emeryville, CA 94608, USA. .
Onorato RM; Technology and Business Development, Berkeley Lights, Inc., 5858 Horton St., Unit 320, Emeryville, CA 94608, USA. .
Chao LK; Research and Development, Amyris, Inc., 5885 Hollis St., Suite 100, Emeryville, CA 94608, USA. .
Wu T; Research and Development, Amyris, Inc., 5885 Hollis St., Suite 100, Emeryville, CA 94608, USA. .
Jiang H; Research and Development, Amyris, Inc., 5885 Hollis St., Suite 100, Emeryville, CA 94608, USA. .
Valley JK; Research and Development, Amyris, Inc., 5885 Hollis St., Suite 100, Emeryville, CA 94608, USA. .
Lionberger TA; Technology and Business Development, Berkeley Lights, Inc., 5858 Horton St., Unit 320, Emeryville, CA 94608, USA. .
Leavell MD; Research and Development, Amyris, Inc., 5885 Hollis St., Suite 100, Emeryville, CA 94608, USA. .
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Źródło :
Lab on a chip [Lab Chip] 2021 Aug 07; Vol. 21 (15), pp. 2901-2912. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
Bioreactors*
High-Throughput Screening Assays*
Fermentation ; Mutagenesis ; Perfusion
Czasopismo naukowe
Tytuł :
Organotypic 3D decellularized matrix tumor spheroids for high-throughput drug screening.
Autorzy :
Ferreira LP; Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
Gaspar VM; Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal. Electronic address: .
Mendes L; Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
Duarte IF; Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
Mano JF; Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal. Electronic address: .
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Źródło :
Biomaterials [Biomaterials] 2021 Aug; Vol. 275, pp. 120983. Date of Electronic Publication: 2021 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms*/drug therapy
High-Throughput Screening Assays*
Drug Evaluation, Preclinical ; Extracellular Matrix ; Female ; Fibroblasts ; Humans ; Spheroids, Cellular ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
A high-throughput screen identifies inhibitors of lung cancer stem cells.
Autorzy :
She X; School of Life Sciences and Technology, Cancer Center, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, China. Electronic address: .
Gao Y; School of Life Sciences and Technology, Cancer Center, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, China. Electronic address: .
Zhao Y; School of Life Sciences and Technology, Cancer Center, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, China.
Yin Y; School of Life Sciences and Technology, Cancer Center, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, China.
Dong Z; School of Life Sciences and Technology, Cancer Center, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200092, China.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Aug; Vol. 140, pp. 111748. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Antineoplastic Agents/*therapeutic use
Lung Neoplasms/*drug therapy
Neoplastic Stem Cells/*drug effects
Animals ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Small Molecule Libraries
Czasopismo naukowe
Tytuł :
[Advances of high-throughput screening system in reengineering of biological entities].
Autorzy :
Yang J; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Su X; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.; University of Science and Technology of China, Hefei 230026, Anhui, China.
Zhu L; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
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Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2021 Jul 25; Vol. 37 (7), pp. 2197-2210.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Directed Molecular Evolution*
High-Throughput Screening Assays*
Biotechnology ; Enzymes ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
BonMOLière: Small-Sized Libraries of Readily Purchasable Compounds, Optimized to Produce Genuine Hits in Biological Screens across the Protein Space.
Autorzy :
Mathai N; Computational Biology Unit (CBU) and Department of Chemistry, University of Bergen, N-5020 Bergen, Norway.
Stork C; Center for Bioinformatics (ZBH), Department of Informatics, Universität Hamburg, 20146 Hamburg, Germany.
Kirchmair J; Computational Biology Unit (CBU) and Department of Chemistry, University of Bergen, N-5020 Bergen, Norway.; Division of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 21; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Algorithms*
Drug Discovery*
High-Throughput Screening Assays/*standards
Proteins/*chemistry
Small Molecule Libraries/*chemistry
Small Molecule Libraries/*pharmacology
Drug Evaluation, Preclinical ; High-Throughput Screening Assays/methods ; Humans
Czasopismo naukowe
Tytuł :
Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers.
Autorzy :
Li C; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Callahan AJ; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Simon MD; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Totaro KA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Mijalis AJ; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Phadke KS; Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Zhang G; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Hartrampf N; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; University of Zurich, Department of Chemistry, Zurich, Switzerland.
Schissel CK; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Zhou M; Sarepta Therapeutics, Cambridge, MA, USA.
Zong H; Sarepta Therapeutics, Cambridge, MA, USA.
Hanson GJ; Sarepta Therapeutics, Cambridge, MA, USA.
Loas A; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
Pohl NLB; Department of Chemistry, Indiana University, Bloomington, IN, USA.
Verhoeven DE; Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Pentelute BL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. .; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. .; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 20; Vol. 12 (1), pp. 4396. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemistry Techniques, Synthetic/*instrumentation
Chemistry, Pharmaceutical/*instrumentation
High-Throughput Screening Assays/*instrumentation
Morpholinos/*chemical synthesis
Oligonucleotides, Antisense/*chemical synthesis
Animals ; COVID-19/drug therapy ; COVID-19/virology ; Chlorocebus aethiops ; Communicable Diseases, Emerging/drug therapy ; Communicable Diseases, Emerging/microbiology ; Disease Models, Animal ; High-Throughput Screening Assays/methods ; Humans ; Morpholinos/pharmacology ; Morpholinos/therapeutic use ; Muscular Dystrophy, Duchenne/drug therapy ; Muscular Dystrophy, Duchenne/genetics ; Oligonucleotides, Antisense/pharmacology ; Oligonucleotides, Antisense/therapeutic use ; Precision Medicine/methods ; RNA, Messenger/antagonists & inhibitors ; RNA, Viral/antagonists & inhibitors ; SARS-CoV-2/genetics ; Time Factors ; Vero Cells
Czasopismo naukowe
Tytuł :
Rapid generation of hybrid biochemical/mechanical cues in heterogeneous droplets for high-throughput screening of cellular responses.
Autorzy :
Zhao X; The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. .
Ou G; School of Sports, China University of Geosciences, Wuhan, 430074, China.
Lei M; The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. .
Zhang Y; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, 518100, China.
Li L; The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. .
Ge A; The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. .
Wang Y; The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. .
Li Y; The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. .
Liu BF; The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. .
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Źródło :
Lab on a chip [Lab Chip] 2021 Jul 13; Vol. 21 (14), pp. 2691-2701.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cues*
High-Throughput Screening Assays*
Signal Transduction ; Stem Cells ; Tissue Engineering
Czasopismo naukowe
Tytuł :
Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma.
Autorzy :
Liang X; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Sun C; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200043, China.; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.
Li C; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Yu H; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200043, China.; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.
Wei X; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Liu X; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Bao W; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200043, China.; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.
Shi Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Sun X; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200043, China.; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.
Khamrakulov M; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Yang C; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200043, China.; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.
Liu H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 9217-9237. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Screening Assays*
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Lymphoma, Large B-Cell, Diffuse/*drug therapy
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/*antagonists & inhibitors
NF-kappa B/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Lymphoma, Large B-Cell, Diffuse/pathology ; Molecular Structure ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/metabolism ; NF-kappa B/metabolism ; Signal Transduction/drug effects ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis.
Autorzy :
Kant R; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Yang MH; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.
Tseng CH; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yen CH; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Li WY; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Tyan YC; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chen M; Department of Urology, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Tzeng CC; Department of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chen WC; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
You K; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
Wang WC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan.
Chen YL; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chen YA; Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jul 08; Vol. 64 (13), pp. 8992-9009. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
High-Throughput Screening Assays*
Antineoplastic Agents/*pharmacology
Glycine N-Methyltransferase/*genetics
Liver Neoplasms/*drug therapy
Proto-Oncogene Proteins c-myc/*antagonists & inhibitors
Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Female ; Glycine N-Methyltransferase/metabolism ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/metabolism ; Liver Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Structure ; Promoter Regions, Genetic/drug effects ; Promoter Regions, Genetic/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Large-scale investigation of single cell activities and response dynamics in a microarray chip with a microfluidics-fabricated microporous membrane.
Autorzy :
Han K; Departments of Biomedical Engineering and Pathology, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, China. .
Sun M
Zhang J
Fu W
Hu R
Liu D
Liu W
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Źródło :
The Analyst [Analyst] 2021 Jul 07; Vol. 146 (13), pp. 4303-4313. Date of Electronic Publication: 2021 Jun 09.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Microfluidics*
Oligonucleotide Array Sequence Analysis ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry.
Autorzy :
Pearson LA; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Green CJ; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Lin; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Petit AP; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Gray DW; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK.
Cowling VH; Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, UK.
Fordyce EAF; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Jul; Vol. 26 (6), pp. 749-756. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Screening Assays*
Antiviral Agents/*pharmacology
Exoribonucleases/*antagonists & inhibitors
Nitro Compounds/*pharmacology
RNA Caps/*antagonists & inhibitors
RNA, Viral/*antagonists & inhibitors
SARS-CoV-2/*drug effects
Thiazoles/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Antiparasitic Agents/chemistry ; Antiparasitic Agents/pharmacology ; Antiviral Agents/chemistry ; COVID-19/virology ; Cloning, Molecular ; Drug Repositioning ; Enzyme Assays ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Exoribonucleases/genetics ; Exoribonucleases/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Kinetics ; Mass Spectrometry/methods ; Methylation ; Nitro Compounds/chemistry ; Prescription Drugs/chemistry ; Prescription Drugs/pharmacology ; RNA Caps/genetics ; RNA Caps/metabolism ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; SARS-CoV-2/enzymology ; SARS-CoV-2/genetics ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Thiazoles/chemistry ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen.
Autorzy :
Bunch TA; Department of Cellular & Molecular Medicine, University of Arizona, Tucson Arizona, USA.
Guhathakurta P; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Lepak VC; Department of Cellular & Molecular Medicine, University of Arizona, Tucson Arizona, USA.
Thompson AR; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Kanassatega RS; Department of Cellular & Molecular Medicine, University of Arizona, Tucson Arizona, USA.
Wilson A; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Thomas DD; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Colson BA; Department of Cellular & Molecular Medicine, University of Arizona, Tucson Arizona, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100840. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Screening Assays*
Actins/*metabolism
Carrier Proteins/*metabolism
Myocardium/*metabolism
Actins/chemistry ; Animals ; Biosensing Techniques ; Calorimetry ; Fluorescence ; Fluorescence Resonance Energy Transfer ; Humans ; Protein Binding ; Rabbits ; Sarcomeres/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry.
Autorzy :
Scholle MD; SAMDI Tech, Inc., Chicago, IL, USA.
Liu C; Aligos Therapeutics, Inc., South San Francisco, CA, USA.
Deval J; Aligos Therapeutics, Inc., South San Francisco, CA, USA.
Gurard-Levin ZA; SAMDI Tech, Inc., Chicago, IL, USA.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Jul; Vol. 26 (6), pp. 766-774. Date of Electronic Publication: 2021 Apr 17.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Antiviral Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Exonucleases/*antagonists & inhibitors
Exoribonucleases/*antagonists & inhibitors
RNA, Viral/*antagonists & inhibitors
SARS-CoV-2/*drug effects
Viral Nonstructural Proteins/*antagonists & inhibitors
Antiviral Agents/chemistry ; COVID-19/virology ; Cloning, Molecular ; Enzyme Assays ; Enzyme Inhibitors/chemistry ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Exonucleases/genetics ; Exonucleases/metabolism ; Exoribonucleases/genetics ; Exoribonucleases/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Kinetics ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; SARS-CoV-2/enzymology ; SARS-CoV-2/genetics ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Substrate Specificity ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Increasing proteomics throughput.
Autorzy :
Slavov N; Department of Bioengineering, Northeastern University, Boston, MA, USA. .; Barnett Institute, Northeastern University, Boston, MA, USA. .
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Źródło :
Nature biotechnology [Nat Biotechnol] 2021 Jul; Vol. 39 (7), pp. 809-810.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms :
High-Throughput Screening Assays*
Proteomics*
Czasopismo naukowe
Tytuł :
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex.
Autorzy :
Khalili Yazdi A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Li F; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Devkota K; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Perveen S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Ghiabi P; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Hajian T; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Bolotokova A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
Vedadi M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Jul; Vol. 26 (6), pp. 757-765. Date of Electronic Publication: 2021 Apr 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Screening Assays*
Adenosine/*analogs & derivatives
RNA Caps/*antagonists & inhibitors
RNA, Viral/*antagonists & inhibitors
Viral Nonstructural Proteins/*antagonists & inhibitors
Viral Regulatory and Accessory Proteins/*antagonists & inhibitors
Adenosine/chemistry ; Adenosine/pharmacology ; COVID-19/virology ; Cloning, Molecular ; Enzyme Assays ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Kinetics ; Methylation ; Models, Molecular ; RNA Caps/genetics ; RNA Caps/metabolism ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; SARS-CoV-2/genetics ; Tritium ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Viral Regulatory and Accessory Proteins/chemistry ; Viral Regulatory and Accessory Proteins/genetics ; Viral Regulatory and Accessory Proteins/metabolism
Czasopismo naukowe
Tytuł :
HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Autorzy :
Ledneczki I; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary. Electronic address: .
Horváth A; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Tapolcsányi P; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Éles J; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Molnár KD; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Vágó I; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Visegrády A; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Kiss L; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Szigetvári Á; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
Kóti J; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
Krámos B; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
Mahó S; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Holm P; Orion Corporation, Turku, Finland.
Kolok S; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Fodor L; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Thán M; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Kostyalik D; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Balázs O; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Vastag M; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Greiner I; Research Management, Gedeon Richter Plc., Budapest, Hungary.
Lévay G; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Lendvai B; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Némethy Z; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113560. Date of Electronic Publication: 2021 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
High-Throughput Screening Assays*
Amides/*pharmacology
Oxalic Acid/*pharmacology
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Allosteric Regulation/drug effects ; Amides/chemical synthesis ; Amides/chemistry ; Animals ; Dose-Response Relationship, Drug ; Humans ; Male ; Molecular Structure ; Oxalic Acid/chemical synthesis ; Oxalic Acid/chemistry ; Rats ; Rats, Wistar ; Structure-Activity Relationship
Czasopismo naukowe

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