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Tytuł:
Enlightening the Path to Protein Engineering: Chemoselective Turn-On Probes for High-Throughput Screening of Enzymatic Activity.
Autorzy:
Hecko S; Institute of Applied Synthetic Chemistry, OC-163, TU Wien, Getreidemarkt 9, 1060 Vienna, Austria.
Schiefer A; Institute of Applied Synthetic Chemistry, OC-163, TU Wien, Getreidemarkt 9, 1060 Vienna, Austria.
Badenhorst CPS; Institute of Biochemistry, Dept. of Biotechnology & Enzyme Catalysis, University of Greifswald, Felix-Hausdorff-Str. 4, 17489 Greifswald, Germany.
Fink MJ; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, Massachusetts 02138, United States.
Mihovilovic MD; Institute of Applied Synthetic Chemistry, OC-163, TU Wien, Getreidemarkt 9, 1060 Vienna, Austria.
Bornscheuer UT; Institute of Biochemistry, Dept. of Biotechnology & Enzyme Catalysis, University of Greifswald, Felix-Hausdorff-Str. 4, 17489 Greifswald, Germany.
Rudroff F; Institute of Applied Synthetic Chemistry, OC-163, TU Wien, Getreidemarkt 9, 1060 Vienna, Austria.
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Źródło:
Chemical reviews [Chem Rev] 2023 Mar 22; Vol. 123 (6), pp. 2832-2901. Date of Electronic Publication: 2023 Feb 28.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
High-Throughput Screening Assays*/methods
Protein Engineering*/methods
Czasopismo naukowe
Szczegóły
Tytuł:
High-Throughput Screening of ToxCast PFAS Chemical Library for Potential Inhibitors of the Human Sodium Iodide Symporter.
Autorzy:
Stoker TE; Neurotoxicology and Endocrine Toxicology Branch, Public Health and Integrated Toxicology Division, Center of Public Health and Environmental Assessments, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States.
Wang J; Neurotoxicology and Endocrine Toxicology Branch, Public Health and Integrated Toxicology Division, Center of Public Health and Environmental Assessments, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States.; Oak Ridge Institute for Science and Education, US Department of Energy, Oak Ridge, Tennessee 37831, United States.
Murr AS; Neurotoxicology and Endocrine Toxicology Branch, Public Health and Integrated Toxicology Division, Center of Public Health and Environmental Assessments, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States.
Bailey JR; Neurotoxicology and Endocrine Toxicology Branch, Public Health and Integrated Toxicology Division, Center of Public Health and Environmental Assessments, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States.; Oak Ridge Institute for Science and Education, US Department of Energy, Oak Ridge, Tennessee 37831, United States.
Buckalew AR; Neurotoxicology and Endocrine Toxicology Branch, Public Health and Integrated Toxicology Division, Center of Public Health and Environmental Assessments, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States.
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Źródło:
Chemical research in toxicology [Chem Res Toxicol] 2023 Mar 20; Vol. 36 (3), pp. 380-389. Date of Electronic Publication: 2023 Feb 23.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
High-Throughput Screening Assays*
Fluorocarbons*
Humans ; Small Molecule Libraries/toxicity ; Iodides/pharmacology ; Iodides/metabolism ; HEK293 Cells
Czasopismo naukowe
Szczegóły
Tytuł:
Reference compounds for characterizing cellular injury in high-content cellular morphology assays.
Autorzy:
Dahlin JL; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA. .; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA. .
Hua BK; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
Zucconi BE; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Nelson SD Jr; Stanley Center, Broad Institute, Cambridge, MA, USA.
Singh S; Imaging Platform, Broad Institute, Cambridge, MA, USA.
Carpenter AE; Imaging Platform, Broad Institute, Cambridge, MA, USA.
Shrimp JH; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Lima-Fernandes E; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Wawer MJ; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
Chung LPW; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
Agrawal A; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
O'Reilly M; Pattern, Broad Institute, Cambridge, MA, USA.
Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Szewczyk M; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Li F; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Lak P; Department of Pharmaceutical Chemistry and Quantitative Biology Institute, University of California San Francisco, San Francisco, CA, USA.
Cuellar M; Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN, USA.
Cole PA; Division of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Meier JL; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Thomas T; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
Baell JB; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
Brown PJ; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Walters MA; Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN, USA.
Clemons PA; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.
Wagner BK; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA. .
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Źródło:
Nature communications [Nat Commun] 2023 Mar 13; Vol. 14 (1), pp. 1364. Date of Electronic Publication: 2023 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
High-Throughput Screening Assays*
Oxidation-Reduction
Czasopismo naukowe
Szczegóły
Tytuł:
Biochemical reaction network topology defines dose-dependent Drug-Drug interactions.
Autorzy:
Babaei M; Medical Systems Biophysics and Bioengineering, Systems Pharmacology and Pharmacy Division, Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333CC, the Netherlands; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy. Electronic address: .
Evers TMJ; Medical Systems Biophysics and Bioengineering, Systems Pharmacology and Pharmacy Division, Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333CC, the Netherlands. Electronic address: .
Shokri F; Leiden University Medical Center, Leiden, 2333ZA, the Netherlands. Electronic address: .
Altucci L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy; BIOGEM, Molecular Biology and Genetics Research Institute, Ariano Irpino, Italy. Electronic address: .
de Lange ECM; Predictive Pharmacology, Systems Pharmacology and Pharmacy Division, Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333CC, the Netherlands. Electronic address: .
Mashaghi A; Medical Systems Biophysics and Bioengineering, Systems Pharmacology and Pharmacy Division, Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333CC, the Netherlands. Electronic address: .
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Źródło:
Computers in biology and medicine [Comput Biol Med] 2023 Mar; Vol. 155, pp. 106584. Date of Electronic Publication: 2023 Jan 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
High-Throughput Screening Assays*
Drug Interactions ; Drug Combinations ; Drug Therapy, Combination ; Kinetics
Czasopismo naukowe
Szczegóły
Tytuł:
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Autorzy:
Dranchak PK; Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Oliphant E; Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Queme B; Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Lamy L; Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Wang Y; Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Huang R; Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Xia M; Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Tao D; Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Inglese J; Department of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.; Metabolic Medicine Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20817, USA.
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Źródło:
Disease models & mechanisms [Dis Model Mech] 2023 Mar 01; Vol. 16 (3). Date of Electronic Publication: 2023 Mar 20.
Typ publikacji:
Journal Article
MeSH Terms:
High-Throughput Screening Assays*/methods
Caenorhabditis elegans*/genetics
Animals ; Humans ; Proteomics ; Drug Discovery/methods ; Small Molecule Libraries/pharmacology
Czasopismo naukowe
Szczegóły
Tytuł:
Establishment of a CaCC-based Cell Model and Method for High-throughput Screening of M3 Receptor Drugs.
Autorzy:
Liu X; School of Laboratory Medicine, Jilin Medical University, Jilin, P.R. China.; School of Medical Technology, Beihua University, Jilin, P.R. China.
Ju X; School of Laboratory Medicine, Jilin Medical University, Jilin, P.R. China.
Hong Q; School of Public Health, Jilin Medical University, Jilin, P.R. China.
Wang X; Jilin drug Inspection Center, Changchun, P.R. China.
Wu M; School of Medicine, Yanbian University, Yanji, P.R. China.
Xing W; School of Medical Technology, Beihua University, Jilin, P.R. China.
Xu M; School of Medical Technology, Beihua University, Jilin, P.R. China.
Hu C; School of Laboratory Medicine, Jilin Medical University, Jilin, P.R. China. .
Hao F; School of Laboratory Medicine, Jilin Medical University, Jilin, P.R. China. .
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Źródło:
Cell biochemistry and biophysics [Cell Biochem Biophys] 2023 Mar; Vol. 81 (1), pp. 49-58. Date of Electronic Publication: 2022 Nov 29.
Typ publikacji:
Journal Article
MeSH Terms:
Chloride Channels*
High-Throughput Screening Assays*
Rats ; Animals ; Receptor, Muscarinic M3/metabolism ; Thyroid Gland/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Mass Spectrometry-Based High-Throughput Quantification of Bioproducts in Liquid Culture.
Autorzy:
Zhou S; Department of Energy Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Fatma Z; Department of Energy Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Xue P; Department of Energy Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Mishra S; Department of Energy Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Cao M; Department of Energy Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Zhao H; Department of Energy Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Sweedler JV; Department of Energy Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
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Źródło:
Analytical chemistry [Anal Chem] 2023 Feb 28; Vol. 95 (8), pp. 4067-4076. Date of Electronic Publication: 2023 Feb 15.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
High-Throughput Screening Assays*
Mass Spectrometry/methods
Czasopismo naukowe
Szczegóły
Tytuł:
Covalent Library Screening by Targeted Mass Spectrometry for Rapid Binding Site Identification.
Autorzy:
Nonomiya J; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080-4990, United States.
Li KS; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080-4990, United States.
Babin BM; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080-4990, United States.
Mulvihill MM; Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080-4990, United States.
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Źródło:
Analytical chemistry [Anal Chem] 2023 Feb 21; Vol. 95 (7), pp. 3779-3788. Date of Electronic Publication: 2023 Jan 27.
Typ publikacji:
Journal Article
MeSH Terms:
High-Throughput Screening Assays*
Drug Discovery*
Binding Sites ; Mass Spectrometry/methods ; Structure-Activity Relationship ; Proteins
Czasopismo naukowe
Szczegóły
Tytuł:
Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (Cyrene ).
Autorzy:
Dekker T; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Harteveld JW; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Wágner G; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
de Vries MCM; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Custers H; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
van de Stolpe AC; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
de Esch IJP; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
Wijtmans M; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 13; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Discovery*/methods
High-Throughput Screening Assays*
Biomass ; Gene Library ; Cellulose
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The PICLS high-throughput screening method for agents extending cellular longevity identifies 2,5-anhydro-D-mannitol as novel anti-aging compound.
Autorzy:
Alfatah M; Bioinformatics Institute (BII), Singapore, 138671, A*STAR, Singapore. .
Eisenhaber F; Bioinformatics Institute (BII), Singapore, 138671, A*STAR, Singapore. .; Genome Institute of Singapore (GIS), Singapore, 138672, A*STAR, Singapore. .; School of Biological Sciences (SBS), Nanyang Technological University (NTU), Singapore, 637551, Singapore. .
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Źródło:
GeroScience [Geroscience] 2023 Feb; Vol. 45 (1), pp. 141-158. Date of Electronic Publication: 2022 Jun 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Saccharomyces cerevisiae*
High-Throughput Screening Assays*
Humans ; Mannitol/pharmacology ; Aging ; Cellular Senescence
Czasopismo naukowe
Szczegóły
Tytuł:
Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening.
Autorzy:
Chlebowicz J; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Akella R; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Humphreys JM; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
He H; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kannangara AR; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wei S; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Posner B; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Goldsmith EJ; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
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Źródło:
Drug design, development and therapy [Drug Des Devel Ther] 2023 Jan 20; Vol. 17, pp. 93-105. Date of Electronic Publication: 2023 Jan 20 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
High-Throughput Screening Assays*
Hypertension*
WNK Lysine-Deficient Protein Kinase 1*/antagonists & inhibitors
Humans ; Protein Isoforms ; Protein Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Szczegóły
Tytuł:
Screening assays for tyrosine kinase inhibitors: A review.
Autorzy:
Gao J; Institute of Pharmaceutical Analysis/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, College of Pharmacy, Jinan University, Guangzhou 510632, China; KU Leuven - University of Leuven, Pharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, O&N2, PB 923, Herestraat 49, 3000 Leuven, Belgium.
Jian J; Institute of Pharmaceutical Analysis/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, College of Pharmacy, Jinan University, Guangzhou 510632, China; KU Leuven - University of Leuven, Pharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, O&N2, PB 923, Herestraat 49, 3000 Leuven, Belgium.
Jiang Z; Institute of Pharmaceutical Analysis/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: .
Van Schepdael A; KU Leuven - University of Leuven, Pharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, O&N2, PB 923, Herestraat 49, 3000 Leuven, Belgium. Electronic address: .
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Źródło:
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2023 Jan 20; Vol. 223, pp. 115166. Date of Electronic Publication: 2022 Nov 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Biological Assay*
High-Throughput Screening Assays*
Cell Cycle ; Protein-Tyrosine Kinases ; Protein Kinase Inhibitors/pharmacology ; Tyrosine
Czasopismo naukowe
Szczegóły
Tytuł:
In-Plate Chemical Synthesis of Isopeptide-Linked SUMOylated Peptide Fluorescence Polarization Reagents for High-Throughput Screening of SENP Preferences.
Autorzy:
Huppelschoten Y; Dept. Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 2, 2333 ZC, Leiden, The Netherlands.; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark.
Mukhopadhyay R; Dept. Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 2, 2333 ZC, Leiden, The Netherlands.
Buchardt J; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark.; Current address: CMC API Development, Novo Nordisk A/S, Novo Nordisk Park, 2880, Bagsvaerd, Denmark.
Nielsen TE; Global Research Technologies, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark.
Vertegaal ACO; Dept. Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 2, 2333 ZC, Leiden, The Netherlands.
Ovaa H; Dept. Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 2, 2333 ZC, Leiden, The Netherlands.
van der Heden van Noort GJ; Dept. Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 2, 2333 ZC, Leiden, The Netherlands.
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Źródło:
Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Jan 17; Vol. 24 (2), pp. e202200601. Date of Electronic Publication: 2022 Dec 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
High-Throughput Screening Assays*/methods
Small Ubiquitin-Related Modifier Proteins*/chemical synthesis
Small Ubiquitin-Related Modifier Proteins*/chemistry
Fluorescent Dyes*/chemical synthesis
Fluorescent Dyes*/chemistry
Endopeptidases/metabolism ; Peptide Hydrolases/metabolism ; Peptides/chemistry ; Proteolysis
Czasopismo naukowe
Szczegóły
Tytuł:
Automating the High-Throughput Screening of Protein-Based Optical Indicators and Actuators.
Autorzy:
Lee J; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, United States.
Campillo B; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, United States.
Hamidian S; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, United States.
Liu Z; Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005, United States.
Shorey M; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, United States.
St-Pierre F; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, United States.; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, Texas 77005, United States.; Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005, United States.; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, United States.
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Źródło:
Biochemistry [Biochemistry] 2023 Jan 17; Vol. 62 (2), pp. 169-177. Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
High-Throughput Screening Assays*
Proteins*/genetics
Humans ; Mutagenesis
Czasopismo naukowe
Szczegóły
Tytuł:
Parallel Pseudo-MRM on the "brick" miniature mass spectrometer for high throughput multi-target screening.
Autorzy:
Zhang H; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Jia H; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China; Kunshan Nier Precision Instrumentation Inc. Kunshan, Suzhou, 215316, China.
Gao Z; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Xiang Y; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Jiang T; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China. Electronic address: .
Xu W; School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
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Źródło:
Talanta [Talanta] 2023 Jan 15; Vol. 252, pp. 123866. Date of Electronic Publication: 2022 Aug 24.
Typ publikacji:
Journal Article
MeSH Terms:
High-Throughput Screening Assays*
Mass Spectrometry/methods ; Calibration
Czasopismo naukowe
Szczegóły
Tytuł:
High-Throughput Screening of Stapled Helical Peptides in Drug Discovery.
Autorzy:
Zhang Y; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Guo J; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Cheng J; Key Laboratory of Advanced Functional Materials of Nanjing, Nanjing Xiaozhuang University, Nanjing 211171, China.
Zhang Z; Department of Chemistry, School of Science, China Pharmaceutical University, Nanjing 211198, China.
Kang F; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Wu X; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Chu Q; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2023 Jan 12; Vol. 66 (1), pp. 95-106. Date of Electronic Publication: 2022 Dec 29.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
High-Throughput Screening Assays*
Peptides*/pharmacology
Peptides*/chemistry
Humans ; Protein Structure, Secondary ; Drug Discovery ; Protein Conformation, alpha-Helical
Czasopismo naukowe
Szczegóły
Tytuł:
Advances in high-throughput mass spectrometry in drug discovery.
Autorzy:
Dueñas ME; Laboratory for Biomedical Mass Spectrometry, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, UK.
Peltier-Heap RE; Discovery Analytical, Screening Profiling and Mechanistic Biology, GSK R&D, Stevenage, UK.
Leveridge M; Discovery Analytical, Screening Profiling and Mechanistic Biology, GSK R&D, Stevenage, UK.
Annan RS; Discovery Analytical, Screening Profiling and Mechanistic Biology, GSK R&D, Stevenage, UK.
Büttner FH; Drug Discovery Sciences, High Throughput Biology, Boehringer Ingelheim Pharma GmbH&CoKG, Biberach, Germany.
Trost M; Laboratory for Biomedical Mass Spectrometry, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, UK.
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Źródło:
EMBO molecular medicine [EMBO Mol Med] 2023 Jan 11; Vol. 15 (1), pp. e14850. Date of Electronic Publication: 2022 Dec 14.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Discovery*/methods
High-Throughput Screening Assays*/methods
Mass Spectrometry
Czasopismo naukowe
Szczegóły
Tytuł:
An Automated High-Throughput Screening (HTS) Spotter for 3D Tumor Spheroid Formation.
Autorzy:
Jeong MH; Central R & D Center, Medical & Bio Decision (MBD) Co., Ltd., Suwon-si 16229, Gyeonggi-do, Republic of Korea.
Kim I; Central R & D Center, Medical & Bio Decision (MBD) Co., Ltd., Suwon-si 16229, Gyeonggi-do, Republic of Korea.
Park K; Central R & D Center, Medical & Bio Decision (MBD) Co., Ltd., Suwon-si 16229, Gyeonggi-do, Republic of Korea.
Ku B; Central R & D Center, Medical & Bio Decision (MBD) Co., Ltd., Suwon-si 16229, Gyeonggi-do, Republic of Korea.
Lee DW; Central R & D Center, Medical & Bio Decision (MBD) Co., Ltd., Suwon-si 16229, Gyeonggi-do, Republic of Korea.; Department of Biomedical Engineering, Gachon University, Seongnam-si 13120, Gyeonggi-do, Republic of Korea.
Park KR; Central R & D Center, Medical & Bio Decision (MBD) Co., Ltd., Suwon-si 16229, Gyeonggi-do, Republic of Korea.
Jeon SY; Central R & D Center, Medical & Bio Decision (MBD) Co., Ltd., Suwon-si 16229, Gyeonggi-do, Republic of Korea.
Kim JE; Central R & D Center, Medical & Bio Decision (MBD) Co., Ltd., Suwon-si 16229, Gyeonggi-do, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 05; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
High-Throughput Screening Assays*/methods
Neoplasms*
Humans ; Cell Culture Techniques/methods ; Drug Evaluation, Preclinical/methods ; Hydrogels ; Spheroids, Cellular ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Efficient Ternary Mn-Based Spinel Oxide with Multiple Active Sites for Oxygen Evolution Reaction Discovered via High-Throughput Screening Methods.
Autorzy:
Ahmed MG; School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore.; Institute of Materials Research and Engineering, A*STAR, Singapore, 138634, Singapore.
Tay YF; Institute of Materials Research and Engineering, A*STAR, Singapore, 138634, Singapore.
Chi X; Singapore Synchrotron Light Source (SSLS), National University of Singapore, Singapore, 117603, Singapore.
Zhang M; School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
Tan JMR; School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore.; Energy Research Institute @NTU IERI@N, Nanyang Technological University, Singapore, 637553, Singapore.; Singapore-HUJ Alliance for Research and Enterprise (SHARE), Nanomaterials for Energy and Energy-Water Nexus (NEW), Campus for Research Excellence and Technological Enterprise (CREATE), Singapore, 138602, Singapore.
Chiam SY; Institute of Materials Research and Engineering, A*STAR, Singapore, 138634, Singapore.
Rusydi A; Singapore Synchrotron Light Source (SSLS), National University of Singapore, Singapore, 117603, Singapore.
Wong LH; School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore.; Energy Research Institute @NTU IERI@N, Nanyang Technological University, Singapore, 637553, Singapore.; Singapore-HUJ Alliance for Research and Enterprise (SHARE), Nanomaterials for Energy and Energy-Water Nexus (NEW), Campus for Research Excellence and Technological Enterprise (CREATE), Singapore, 138602, Singapore.
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Źródło:
Small (Weinheim an der Bergstrasse, Germany) [Small] 2023 Jan; Vol. 19 (2), pp. e2204520. Date of Electronic Publication: 2022 Nov 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Oxides*
High-Throughput Screening Assays*
Catalytic Domain ; Oxygen
Czasopismo naukowe
Szczegóły
Tytuł:
Biosensor-assisted titratable CRISPRi high-throughput (BATCH) screening for over-production phenotypes.
Autorzy:
Wang J; School of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA, 30602, USA.
Li C; School of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA, 30602, USA.
Jiang T; School of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA, 30602, USA.
Yan Y; School of Chemical, Materials and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA, 30602, USA. Electronic address: .
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Źródło:
Metabolic engineering [Metab Eng] 2023 Jan; Vol. 75, pp. 58-67. Date of Electronic Publication: 2022 Nov 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Escherichia coli*/genetics
Escherichia coli*/metabolism
High-Throughput Screening Assays*
Coumaric Acids ; Phenotype ; CRISPR-Cas Systems/genetics ; Metabolic Engineering
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 9012

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