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Tytuł:
Development of a functional salivary gland tissue chip with potential for high-content drug screening.
Autorzy:
Song Y; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.
Uchida H; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Sharipol A; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.
Piraino L; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.; Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.
Mereness JA; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Ingalls MH; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Rebhahn J; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester Medical Center, Rochester, NY, USA.
Newlands SD; Department of Otolaryngology, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
DeLouise LA; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.; Department of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.; Materials Science Program, University of Rochester, Rochester, NY, USA.
Ovitt CE; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA.; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.
Benoit DSW; Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA. .; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA. .; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA. .; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA. .; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA. .; Materials Science Program, University of Rochester, Rochester, NY, USA. .; Department of Chemical Engineering, University of Rochester, Rochester, NY, USA. .; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA. .
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Źródło:
Communications biology [Commun Biol] 2021 Mar 19; Vol. 4 (1), pp. 361. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Video-Audio Media
MeSH Terms:
Drug Evaluation, Preclinical*
High-Throughput Screening Assays*
Tissue Array Analysis*
Acinar Cells/*drug effects
Radiation Injuries/*prevention & control
Salivary Glands/*drug effects
Xerostomia/*prevention & control
Acinar Cells/metabolism ; Acinar Cells/radiation effects ; Animals ; Calcium Signaling/drug effects ; Cells, Cultured ; Female ; Humans ; Hydrogels ; Male ; Mice, Inbred C57BL ; Microbubbles ; Middle Aged ; Parotid Gland/drug effects ; Parotid Gland/metabolism ; Parotid Gland/radiation effects ; Phenotype ; Polyethylene Glycols/chemistry ; Radiation Injuries/etiology ; Radiation Injuries/metabolism ; Salivary Glands/metabolism ; Salivary Glands/radiation effects ; Xerostomia/etiology ; Xerostomia/metabolism ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Metabolic stability studies of lead compounds supported by separation techniques and chemometrics analysis.
Autorzy:
Ulenberg S; Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Gdańsk, Poland.
Bączek T; Department of Pharmaceutical Chemistry, Medical University of Gdańsk, Gdańsk, Poland.
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Źródło:
Journal of separation science [J Sep Sci] 2021 Jan; Vol. 44 (1), pp. 373-386. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Biotransformation*
Drug Evaluation, Preclinical*
High-Throughput Screening Assays*
Pharmaceutical Preparations/*analysis
Humans ; Pharmaceutical Preparations/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity.
Autorzy:
Kasprzyk R; Centre of New Technologies, University of Warsaw, Banacha 2c, 02097, Warsaw, Poland.; College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Banacha 2c, 02097, Warsaw, Poland.
Fido M; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02093, Warsaw, Poland.
Mamot A; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02093, Warsaw, Poland.
Wanat P; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02093, Warsaw, Poland.
Smietanski M; Centre of New Technologies, University of Warsaw, Banacha 2c, 02097, Warsaw, Poland.
Kopcial M; Centre of New Technologies, University of Warsaw, Banacha 2c, 02097, Warsaw, Poland.; College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Banacha 2c, 02097, Warsaw, Poland.
Cowling VH; Centre of Gene Regulation and Expression, School of Life Sciences, University of Dundee, DD1 5EH, Dundee, UK.
Kowalska J; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02093, Warsaw, Poland.
Jemielity J; Centre of New Technologies, University of Warsaw, Banacha 2c, 02097, Warsaw, Poland.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Sep 01; Vol. 26 (49), pp. 11266-11275. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Evaluation, Preclinical*
Enzyme Assays*
High-Throughput Screening Assays*
Enzyme Inhibitors/*isolation & purification
Enzyme Inhibitors/*pharmacology
Methyltransferases/*metabolism
RNA Caps/*metabolism
Guanine/analogs & derivatives ; Guanine/metabolism ; Humans ; Methyltransferases/antagonists & inhibitors ; RNA Caps/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Integration of a miniaturized DMMB assay with high-throughput screening for identifying regulators of proteoglycan metabolism.
Autorzy:
Sun Y; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, China.
Tsui YK; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, China.
Yu M; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, China.; Department of Diagnostic Radiology, National University of Singapore, Singapore, Singapore.
Lyu M; Core Laboratory, The University of Hong Kong Shenzhen Hospital, Shenzhen, China.
Cheung K; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, China.
Kao R; Department of Microbiology, The University of Hong Kong, Hong Kong, China. .
Leung V; Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, China. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 20; Vol. 12 (1), pp. 1083. Date of Electronic Publication: 2022 Jan 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chondrocytes/*drug effects
Drug Evaluation, Preclinical/*methods
Proteoglycans/*metabolism
Animals ; Cells, Cultured ; Chondrocytes/metabolism ; Chondroitin Sulfates/metabolism ; Glycosaminoglycans/analysis ; High-Throughput Screening Assays/methods ; Methylene Blue/analogs & derivatives ; Methylene Blue/chemistry ; Osteoarthritis/metabolism ; Reproducibility of Results ; Swine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms.
Autorzy:
Atakan HB; Laboratory of Microsystems, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland.
Xiang R; Laboratory of Microsystems, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland.
Cornaglia M; Laboratory of Microsystems, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland.
Mouchiroud L; Laboratory of Integrative Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland.
Katsyuba E; Laboratory of Integrative Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland.
Auwerx J; Laboratory of Integrative Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland.
Gijs MAM; Laboratory of Microsystems, Ecole Polytechnique Fédérale de Lausanne, CH-1015, Lausanne, Switzerland. .
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Źródło:
Scientific reports [Sci Rep] 2019 Oct 04; Vol. 9 (1), pp. 14340. Date of Electronic Publication: 2019 Oct 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms:
Lab-On-A-Chip Devices*
Caenorhabditis elegans/*physiology
Drug Evaluation, Preclinical/*instrumentation
High-Throughput Screening Assays/*instrumentation
Microfluidic Analytical Techniques/*instrumentation
Animals ; Caenorhabditis elegans/drug effects ; Drug Evaluation, Preclinical/methods ; Embryonic Development/drug effects ; High-Throughput Screening Assays/methods ; Larva/drug effects ; Larva/growth & development ; Models, Animal ; Phenotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Induced Pluripotent Stem Cells (iPSCs)-Roles in Regenerative Therapies, Disease Modelling and Drug Screening.
Autorzy:
Aboul-Soud MAM; Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Alzahrani AJ; Department of Clinical Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia.
Mahmoud A; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
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Źródło:
Cells [Cells] 2021 Sep 05; Vol. 10 (9). Date of Electronic Publication: 2021 Sep 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Drug Evaluation, Preclinical*
Regenerative Medicine*
Stem Cell Transplantation*
Translational Research, Biomedical*
Cell Differentiation/*drug effects
Cell Proliferation/*drug effects
Induced Pluripotent Stem Cells/*drug effects
Induced Pluripotent Stem Cells/*transplantation
Regeneration/*drug effects
Animals ; Cell Line ; Gene Expression Regulation, Developmental ; High-Throughput Screening Assays ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Phenotype ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation.
Autorzy:
Nizami S; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
Millar V; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.; National Phenotypic Screening Centre, Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
Arunasalam K; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
Zarganes-Tzitzikas T; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
Brough D; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK.; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, M13 9PT, UK.
Tresadern G; Janssen Research and Development, Turnhoutseweg 30, 2340, Beerse, Belgium.
Brennan PE; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
Davis JB; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
Ebner D; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK. .; National Phenotypic Screening Centre, Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK. .
Di Daniel E; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK. .; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jul 28; Vol. 11 (1), pp. 15319. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Evaluation, Preclinical/*methods
High-Throughput Screening Assays/*methods
Inflammasomes/*drug effects
Macrophages/*drug effects
NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors
Animals ; CARD Signaling Adaptor Proteins/metabolism ; Caspase 1/biosynthesis ; Cells, Cultured ; Dimethyl Sulfoxide/pharmacology ; Drug Discovery ; Furans/pharmacology ; Genes, Reporter ; Indenes/pharmacology ; Interleukin-1beta/biosynthesis ; Lipopolysaccharides/pharmacology ; Mice ; Nigericin/pharmacology ; Phenotype ; Pyroptosis/drug effects ; Recombinant Proteins/metabolism ; Small Molecule Libraries ; Sulfonamides/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Practical High-Throughput Method to Screen Compounds for Anthelmintic Activity against Caenorhabditis elegans .
Autorzy:
Taki AC; Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC 3010, Australia.
Byrne JJ; Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC 3010, Australia.
Boag PR; Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Jabbar A; Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC 3010, Australia.
Gasser RB; Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Parkville, VIC 3010, Australia.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Jul 08; Vol. 26 (14). Date of Electronic Publication: 2021 Jul 08.
Typ publikacji:
Journal Article
MeSH Terms:
Anthelmintics/*analysis
Drug Evaluation, Preclinical/*methods
High-Throughput Screening Assays/*methods
Animals ; Anthelmintics/isolation & purification ; Anthelmintics/pharmacology ; Anti-Infective Agents/pharmacology ; Antinematodal Agents/analysis ; Antinematodal Agents/pharmacology ; Caenorhabditis elegans/drug effects ; Drug Resistance/drug effects ; Larva/drug effects ; Small Molecule Libraries/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Drug discovery: Insights from the invertebrate Caenorhabditis elegans.
Autorzy:
Giunti S; Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB) CCT UNS-CONICET, Bahía Blanca, Argentina.; Dpto de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Andersen N; Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB) CCT UNS-CONICET, Bahía Blanca, Argentina.; Dpto de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Rayes D; Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB) CCT UNS-CONICET, Bahía Blanca, Argentina.; Dpto de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
De Rosa MJ; Instituto de Investigaciones Bioquímicas de Bahía Blanca (INIBIBB) CCT UNS-CONICET, Bahía Blanca, Argentina.; Dpto de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2021 Apr; Vol. 9 (2), pp. e00721.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Caenorhabditis elegans/*physiology
Drug Discovery/*methods
Drug Evaluation, Preclinical/*methods
Animals ; Drug Evaluation, Preclinical/economics ; High-Throughput Screening Assays/economics ; High-Throughput Screening Assays/methods ; Humans ; Models, Animal ; Species Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening.
Autorzy:
Grad I; Department of Tumor Biology, Institute of Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Hanes R; Department of Tumor Biology, Institute of Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.; Department of Molecular Cell Biology, Institute of Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ayuda-Durán P; Faculty of Medicine, Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Kuijjer ML; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway.
Enserink JM; Department of Molecular Cell Biology, Institute of Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Faculty of Mathematics and Natural Sciences, Department of Biosciences, University of Oslo, Oslo, Norway.
Meza-Zepeda LA; Department of Tumor Biology, Institute of Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.; Department of Core Facilities, Genomics Core Facility, Institute of Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway.
Myklebost O; Department of Tumor Biology, Institute of Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway.
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Źródło:
PloS one [PLoS One] 2021 Mar 10; Vol. 16 (3), pp. e0248140. Date of Electronic Publication: 2021 Mar 10 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Evaluation, Preclinical/*methods
High-Throughput Screening Assays/*methods
Liposarcoma/*drug therapy
Acrylamides/pharmacology ; Antineoplastic Agents/analysis ; Antineoplastic Agents/chemistry ; Biomarkers, Pharmacological ; Boron Compounds/pharmacology ; Cell Line, Tumor ; Diterpenes/pharmacology ; Epoxy Compounds/pharmacology ; Glycine/analogs & derivatives ; Glycine/pharmacology ; Humans ; Hydroxamic Acids/pharmacology ; Imidazoles/pharmacology ; Naphthoquinones/pharmacology ; Phenanthrenes/pharmacology ; Piperidines/pharmacology ; Pyridazines/pharmacology ; Quinolines/pharmacology ; Small Molecule Libraries/pharmacology ; Sulfonamides/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease.
Autorzy:
Baker JD; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, United States of America.; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States of America.
Uhrich RL; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States of America.
Kraemer GC; Thomas Jefferson High School, Auburn, WA, United States of America.
Love JE; Western Washington Pathology, Tacoma, WA, United States of America.
Kraemer BC; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, United States of America.; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States of America.; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States of America.; Department of Pathology, University of Washington, Seattle, WA, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Feb 01; Vol. 16 (2), pp. e0245962. Date of Electronic Publication: 2021 Feb 01 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Drug Evaluation, Preclinical*
Drug Repositioning*
Antiviral Agents/*pharmacology
Antiviral Agents/*therapeutic use
Hepacivirus/*drug effects
Hepatitis C/*drug therapy
Protease Inhibitors/*pharmacology
SARS-CoV-2/*drug effects
Biological Assay ; Fluorescence ; High-Throughput Screening Assays ; Humans ; Reproducibility of Results
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clinically relevant inflammatory breast cancer patient-derived xenograft-derived ex vivo model for evaluation of tumor-specific therapies.
Autorzy:
Eckhardt BL; Department of Breast Medical Oncology, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.; Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
Gagliardi M; Department of Breast Medical Oncology, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
Iles L; Department of Experimental Therapeutics, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
Evans K; Department of Investigational Cancer Therapeutics, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
Ivan C; Department of Experimental Therapeutics, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
Liu X; Department of Experimental Therapeutics, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
Liu CG; Department of Experimental Therapeutics, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
Souza G; Nano3D Biosciences, Houston, Texas, United States of America.; University of Texas Health Science Center, Houston, Texas, United States of America.
Rao A; Department of Bioinformatics and Computational Biology, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
Meric-Bernstam F; Department of Investigational Cancer Therapeutics, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
Ueno NT; Department of Breast Medical Oncology, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.; Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
Bartholomeusz GA; Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.; Department of Experimental Therapeutics, The University of Texas, MD, Anderson Cancer Center, Houston, Texas, United States of America.
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Źródło:
PloS one [PLoS One] 2018 May 16; Vol. 13 (5), pp. e0195932. Date of Electronic Publication: 2018 May 16 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Evaluation, Preclinical*
High-Throughput Screening Assays*
Xenograft Model Antitumor Assays*
Antineoplastic Agents/*pharmacology
Biomarkers, Tumor/*genetics
Inflammatory Breast Neoplasms/*pathology
Animals ; Female ; Gene Expression Profiling ; Humans ; Inflammatory Breast Neoplasms/drug therapy ; Inflammatory Breast Neoplasms/genetics ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Drug Screening with Genetically Encoded Fluorescent Sensors: Today and Tomorrow.
Autorzy:
Potekhina ES; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Bass DY; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Kelmanson IV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Fetisova ES; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
Ivanenko AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
Belousov VV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.; Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency, 117997 Moscow, Russia.
Bilan DS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 25; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Biosensing Techniques*
Drug Evaluation, Preclinical*/methods
Genetic Testing*/methods
Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacology ; Biomarkers ; Calcium Signaling/drug effects ; Drug Screening Assays, Antitumor ; Energy Metabolism/drug effects ; High-Throughput Screening Assays ; Humans ; Receptors, G-Protein-Coupled ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods.
Autorzy:
Shiroma Y; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Fujita G; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Yamamoto T; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Takahashi RU; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Kumar A; Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
Zhang KYJ; Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.
Ito A; Laboratory of Cell Signaling, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan..; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Osada H; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Yoshida M; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.; Seed Compounds Exploratory Unit for Drug Discovery Platform, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Tahara H; Department of Cellular and Molecular Biology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.; The Research Center for Drug Development and Biomarker Discovery, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 30; Vol. 21 (23). Date of Electronic Publication: 2020 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Evaluation, Preclinical/*methods
Fluorescence Resonance Energy Transfer/*methods
Transcription Factor RelA/*antagonists & inhibitors
Transcription Factor RelA/*chemistry
Binding Sites ; Cell Line, Tumor ; DNA/chemistry ; DNA/metabolism ; High-Throughput Screening Assays ; Humans ; Models, Molecular ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Application of In Vitro Metabolism Activation in High-Throughput Screening.
Autorzy:
Ooka M; National Center for Advancing Translational Sciences, Division for Pre-Clinical Innovation, National Institutes of Health, Bethesda, MD 20892, USA.
Lynch C; National Center for Advancing Translational Sciences, Division for Pre-Clinical Innovation, National Institutes of Health, Bethesda, MD 20892, USA.
Xia M; National Center for Advancing Translational Sciences, Division for Pre-Clinical Innovation, National Institutes of Health, Bethesda, MD 20892, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 31; Vol. 21 (21). Date of Electronic Publication: 2020 Oct 31.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Drug Evaluation, Preclinical/*methods
Hepatocytes/*metabolism
High-Throughput Screening Assays/*methods
Cells, Cultured ; Hepatocytes/drug effects ; Humans ; Inactivation, Metabolic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A high throughput screening system for studying the effects of applied mechanical forces on reprogramming factor expression.
Autorzy:
Lee J; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station, BME 5.202D, C0800, Austin, TX, 78712, USA.
Armenta Ochoa M; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station, BME 5.202D, C0800, Austin, TX, 78712, USA.
Maceda P; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station, BME 5.202D, C0800, Austin, TX, 78712, USA.
Yoon E; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station, BME 5.202D, C0800, Austin, TX, 78712, USA.
Samarneh L; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station, BME 5.202D, C0800, Austin, TX, 78712, USA.
Wong M; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station, BME 5.202D, C0800, Austin, TX, 78712, USA.
Baker AB; Department of Biomedical Engineering, University of Texas at Austin, 1 University Station, BME 5.202D, C0800, Austin, TX, 78712, USA. .; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA. .; The Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, TX, USA. .; Institute for Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin, Austin, TX, USA. .
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Źródło:
Scientific reports [Sci Rep] 2020 Sep 22; Vol. 10 (1), pp. 15469. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Stress, Mechanical*
Cellular Reprogramming/*drug effects
Drug Evaluation, Preclinical/*methods
Embryo, Mammalian/*metabolism
Embryonic Stem Cells/*metabolism
Fibroblasts/*metabolism
Small Molecule Libraries/*pharmacology
Animals ; Embryo, Mammalian/cytology ; Embryo, Mammalian/drug effects ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/drug effects ; Female ; Fibroblasts/cytology ; Fibroblasts/drug effects ; High-Throughput Screening Assays ; Male ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Screening and Evaluation of Novel Compounds against Hepatitis B Virus Polymerase Using Highly Purified Reverse Transcriptase Domain.
Autorzy:
Ohsaki E; Division of Virology, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
Ueda K; Division of Virology, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
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Źródło:
Viruses [Viruses] 2020 Jul 31; Vol. 12 (8). Date of Electronic Publication: 2020 Jul 31.
Typ publikacji:
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Evaluation, Preclinical*
Antiviral Agents/*pharmacology
Gene Products, pol/*antagonists & inhibitors
Hepatitis B virus/*drug effects
Reverse Transcriptase Inhibitors/*pharmacology
Hep G2 Cells ; Hepatitis B virus/enzymology ; High-Throughput Screening Assays ; Humans ; Nucleic Acid Synthesis Inhibitors/pharmacology ; RNA-Directed DNA Polymerase ; Small Molecule Libraries ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Stratification and prediction of drug synergy based on target functional similarity.
Autorzy:
Yang M; Heidelberg University, Faculty of Biosciences, Germany.; RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine (JRC-COMBINE), Aachen, Germany.; Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Jaaks P; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SA, UK.
Dry J; Oncology, IMED Biotech Unit, AstraZeneca R&D Boston, Waltham, MA, USA.
Garnett M; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SA, UK.
Menden MP; Institute of Computational Biology, Helmholtz Zentrum München - German Research Centre for Environmental Health, 85764, Munich, Germany.; Department of Biology, Ludwig-Maximilians University Munich, 82152, Martinsried, Germany.; German Centre for Diabetes Research (DZD e.V.), 85764, Neuherberg, Germany.
Saez-Rodriguez J; RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine (JRC-COMBINE), Aachen, Germany. .; Institute for Computational Biomedicine, Heidelberg University Hospital and Heidelberg University, Faculty of Medicine, Bioquant, Heidelberg, Germany. .
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Źródło:
NPJ systems biology and applications [NPJ Syst Biol Appl] 2020 Jun 02; Vol. 6 (1), pp. 16. Date of Electronic Publication: 2020 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Evaluation, Preclinical/*methods
Drug Therapy, Combination/*methods
Breast Neoplasms/metabolism ; Cell Line, Tumor ; Colorectal Neoplasms/metabolism ; Computational Biology/methods ; Drug Synergism ; High-Throughput Screening Assays/methods ; Humans ; Imidazoles/pharmacology ; Machine Learning ; Oximes/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural dynamic studies on identification of EGCG analogues for the inhibition of Human Papillomavirus E7.
Autorzy:
Aarthy M; Computer Aided Drug Design and Molecular Modeling Lab, Department of Bioinformatics, Alagappa University, Karaikudi, 630004, India.
Panwar U; Computer Aided Drug Design and Molecular Modeling Lab, Department of Bioinformatics, Alagappa University, Karaikudi, 630004, India.
Singh SK; Computer Aided Drug Design and Molecular Modeling Lab, Department of Bioinformatics, Alagappa University, Karaikudi, 630004, India. .
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Źródło:
Scientific reports [Sci Rep] 2020 May 26; Vol. 10 (1), pp. 8661. Date of Electronic Publication: 2020 May 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Catechin/*analogs & derivatives
Drug Evaluation, Preclinical/*methods
Human papillomavirus 16/*drug effects
Papillomavirus E7 Proteins/*antagonists & inhibitors
Papillomavirus Infections/*drug therapy
Uterine Cervical Neoplasms/*prevention & control
Antiviral Agents/pharmacology ; Catechin/chemistry ; Catechin/pharmacology ; Cell Proliferation/genetics ; Chemoprevention/methods ; Drug Discovery ; Female ; High-Throughput Screening Assays ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Principal Component Analysis ; Protein Conformation/drug effects ; Uterine Cervical Neoplasms/virology ; Virus Internalization/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A High-Throughput HIV-1 Drug Screening Platform, Based on Lentiviral Vectors and Compatible with Biosafety Level-1.
Autorzy:
Ellinger B; Department Screening Port, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, 22525 Hamburg, Germany.; Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Partner Site Hamburg, 22525 Hamburg, Germany.
Pohlmann D; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.
Woens J; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.
Jäkel FM; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.
Reinshagen J; Department Screening Port, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, 22525 Hamburg, Germany.; Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Partner Site Hamburg, 22525 Hamburg, Germany.
Stocking C; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.; Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, 20251 Hamburg, Germany.
Prassolov VS; Engelhardt-Institute of Molecular Biology, Russian Academy of Sciences, 117984 Moscow, Russia.
Fehse B; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.; German Center for Infection Research (DZIF), partner site Hamburg, 20246 Hamburg, Germany.
Riecken K; Research Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.
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Źródło:
Viruses [Viruses] 2020 May 25; Vol. 12 (5). Date of Electronic Publication: 2020 May 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Vectors*
Drug Evaluation, Preclinical/*methods
HIV-1/*drug effects
High-Throughput Screening Assays/*methods
Lentivirus/*genetics
Animals ; Anti-HIV Agents/pharmacology ; Cell Line ; Containment of Biohazards ; Drug Development ; Drug Discovery ; HEK293 Cells ; Humans ; Mice ; Viral Envelope Proteins ; Virion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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