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Wyszukujesz frazę ""High-throughput screening"" wg kryterium: Temat


Tytuł :
HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Autorzy :
Ledneczki I; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary. Electronic address: .
Horváth A; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Tapolcsányi P; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Éles J; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Molnár KD; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Vágó I; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Visegrády A; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Kiss L; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Szigetvári Á; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
Kóti J; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
Krámos B; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
Mahó S; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
Holm P; Orion Corporation, Turku, Finland.
Kolok S; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Fodor L; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Thán M; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Kostyalik D; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Balázs O; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Vastag M; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Greiner I; Research Management, Gedeon Richter Plc., Budapest, Hungary.
Lévay G; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Lendvai B; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Némethy Z; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113560. Date of Electronic Publication: 2021 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
High-Throughput Screening Assays*
Amides/*pharmacology
Oxalic Acid/*pharmacology
alpha7 Nicotinic Acetylcholine Receptor/*metabolism
Allosteric Regulation/drug effects ; Amides/chemical synthesis ; Amides/chemistry ; Animals ; Dose-Response Relationship, Drug ; Humans ; Male ; Molecular Structure ; Oxalic Acid/chemical synthesis ; Oxalic Acid/chemistry ; Rats ; Rats, Wistar ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
High-throughput virtual screening followed by in vitro investigation to identify new lead inhibitors of Cyclin Dependent Kinase 4.
Autorzy :
Divya V; Department of Chemistry, Milad-E-Sherief Memorial College, Kayamkulam, Affiliated to University of Kerala, Kerala, PIN: 690502, India. Electronic address: .
Pushpa VL; Research Department of Chemistry, DST-FIST Supported Department Sree Narayana College, Kollam, Affiliated to University of Kerala, Kerala, PIN: 691001, India. Electronic address: .
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Źródło :
Journal of molecular graphics & modelling [J Mol Graph Model] 2021 Dec; Vol. 109, pp. 108020. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*
High-Throughput Screening Assays*
Cyclin-Dependent Kinase 2 ; Cyclin-Dependent Kinase 4 ; Female ; Humans ; MCF-7 Cells ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł :
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment.
Autorzy :
Rotordam MG; Nanion Technologies GmbH, Germany.
Obergrussberger A; Nanion Technologies GmbH, Germany. Electronic address: .
Brinkwirth N; Nanion Technologies GmbH, Germany.
Takasuna K; Axcelead Drug Discovery Partners, Inc., Japan.
Becker N; Nanion Technologies GmbH, Germany.
Horváth A; Nanion Technologies GmbH, Germany.
Goetze TA; Nanion Technologies GmbH, Germany.
Rapedius M; Nanion Technologies GmbH, Germany.
Furukawa H; Axcelead Drug Discovery Partners, Inc., Japan.
Hasegawa Y; Axcelead Drug Discovery Partners, Inc., Japan.
Oka T; Nanion Technologies Japan K.K., Japan.
Fertig N; Nanion Technologies GmbH, Germany.
Stoelzle-Feix S; Nanion Technologies GmbH, Germany.
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Źródło :
Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2021 Nov-Dec; Vol. 112, pp. 107125. Date of Electronic Publication: 2021 Sep 06.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
High-Throughput Screening Assays*
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Patch-Clamp Techniques
Czasopismo naukowe
Tytuł :
A robust high-throughput fluorescent polarization assay for the evaluation and screening of SARS-CoV-2 fusion inhibitors.
Autorzy :
Yin X; School of Marine Science, Sun Yat-sen University, Zhuhai 519080, China.
Chen L; School of Marine Science, Sun Yat-sen University, Zhuhai 519080, China.
Yuan S; School of Marine Science, Sun Yat-sen University, Zhuhai 519080, China.
Liu L; School of Marine Science, Sun Yat-sen University, Zhuhai 519080, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519080, China.
Gao Z; School of Marine Science, Sun Yat-sen University, Zhuhai 519080, China; State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519080, China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Nov; Vol. 116, pp. 105362. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescence Polarization*
High-Throughput Screening Assays*
Alkenes/*analysis
Antiviral Agents/*analysis
Peptides/*analysis
Polyphenols/*analysis
Alkenes/pharmacology ; Antiviral Agents/pharmacology ; Drug Evaluation, Preclinical ; Humans ; Molecular Structure ; Peptides/pharmacology ; Polyphenols/pharmacology ; SARS-CoV-2/drug effects
Czasopismo naukowe
Tytuł :
Recent advances in droplet microfluidics for enzyme and cell factory engineering.
Autorzy :
Yang J; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.; National Technology Innovation Center of Synthetic Biology, Tianjin, China.
Tu R; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.; National Technology Innovation Center of Synthetic Biology, Tianjin, China.
Yuan H; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.; National Technology Innovation Center of Synthetic Biology, Tianjin, China.
Wang Q; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.; National Technology Innovation Center of Synthetic Biology, Tianjin, China.
Zhu L; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.; National Technology Innovation Center of Synthetic Biology, Tianjin, China.
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Źródło :
Critical reviews in biotechnology [Crit Rev Biotechnol] 2021 Nov; Vol. 41 (7), pp. 1023-1045. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
High-Throughput Screening Assays*
Microfluidics*
Biotechnology ; Cell Engineering
Czasopismo naukowe
Tytuł :
A facile method for high-throughput screening of drug-eluting coatings in droplet microarrays based on ultrasonic spray deposition.
Autorzy :
Wang C; MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. .
Xue Y; MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. .
Huang J; MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. .
Ren K; MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. .
Greiner A; Macromolecular Chemistry II, University of Bayreuth, Universitätsstr. 30, 95440 Bayreuth, Germany.
Agarwal S; Macromolecular Chemistry II, University of Bayreuth, Universitätsstr. 30, 95440 Bayreuth, Germany.
Ji J; MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China. .
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Źródło :
Biomaterials science [Biomater Sci] 2021 Oct 12; Vol. 9 (20), pp. 6787-6794. Date of Electronic Publication: 2021 Oct 12.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Ultrasonics*
Drug Liberation ; Excipients ; Polymers ; Water
Czasopismo naukowe
Tytuł :
Continuous Spectrophotometric Assay for High-Throughput Screening of Predominant d-Allulose 3-Epimerases.
Autorzy :
Li C; Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education; Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology; National Engineering Laboratory for Industrial Enzymes, Tianjin 300457, P. R. China.
Zhang W; Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education; Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology; National Engineering Laboratory for Industrial Enzymes, Tianjin 300457, P. R. China.
Wei C; Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education; Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology; National Engineering Laboratory for Industrial Enzymes, Tianjin 300457, P. R. China.
Gao X; Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education; Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology; National Engineering Laboratory for Industrial Enzymes, Tianjin 300457, P. R. China.
Mao S; Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education; Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology; National Engineering Laboratory for Industrial Enzymes, Tianjin 300457, P. R. China.
Lu F; Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education; Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology; National Engineering Laboratory for Industrial Enzymes, Tianjin 300457, P. R. China.
Qin HM; Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education; Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology; National Engineering Laboratory for Industrial Enzymes, Tianjin 300457, P. R. China.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Oct 06; Vol. 69 (39), pp. 11637-11645. Date of Electronic Publication: 2021 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Racemases and Epimerases*
Carbohydrate Epimerases/metabolism ; Fructose ; Hydrogen-Ion Concentration ; Kinetics
Czasopismo naukowe
Tytuł :
Anaerobic fluorescent reporters for cell identification, microbial cell biology and high-throughput screening of microbiota and genomic libraries.
Autorzy :
Streett H; Delaware Biotechnology Institute, University of Delaware, 590 Avenue 1743, Newark, DE 19713, USA; Department of Biological Sciences, University of Delaware, 118 Wolf Hall, Newark, DE 19716, USA.
Charubin K; Delaware Biotechnology Institute, University of Delaware, 590 Avenue 1743, Newark, DE 19713, USA; Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy St., Newark, DE 19716, USA.
Papoutsakis ET; Delaware Biotechnology Institute, University of Delaware, 590 Avenue 1743, Newark, DE 19713, USA; Department of Biological Sciences, University of Delaware, 118 Wolf Hall, Newark, DE 19716, USA; Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy St., Newark, DE 19716, USA. Electronic address: .
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Źródło :
Current opinion in biotechnology [Curr Opin Biotechnol] 2021 Oct; Vol. 71, pp. 151-163. Date of Electronic Publication: 2021 Aug 07.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
High-Throughput Screening Assays*
Microbiota*
Anaerobiosis ; Genes, Reporter ; Genomic Library
Czasopismo naukowe
Tytuł :
Advancing a rapid, high throughput screening platform for optimization of lentivirus production.
Autorzy :
Gopal S; Department of Chemical and Biological Engineering, and Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
Osborne AE; MassBiologics, University of Massachusetts Medical School, Mattapan, Massachusetts, USA.
Hock L; MassBiologics, University of Massachusetts Medical School, Mattapan, Massachusetts, USA.
Zemianek J; MassBiologics, University of Massachusetts Medical School, Mattapan, Massachusetts, USA.
Fang K; MassBiologics, University of Massachusetts Medical School, Mattapan, Massachusetts, USA.
Gee G; MassBiologics, University of Massachusetts Medical School, Mattapan, Massachusetts, USA.
Ghosh R; Department of Chemical and Biological Engineering, and Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
McNally D; MassBiologics, University of Massachusetts Medical School, Mattapan, Massachusetts, USA.
Cramer SM; Department of Chemical and Biological Engineering, and Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.; Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Dordick JS; Department of Chemical and Biological Engineering, and Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.; Departments of Biomedical Engineering and Biological Sciences, Rensselaer Polytechnic Institute, Troy, New York, USA.
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Źródło :
Biotechnology journal [Biotechnol J] 2021 Oct; Vol. 16 (10), pp. e2000621. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Lentivirus*/genetics
Genetic Vectors/genetics ; HEK293 Cells ; Humans ; Transfection
Czasopismo naukowe
Tytuł :
A High-throughput Approach to Identify Effective Systemic Agents for the Treatment of Anaplastic Thyroid Carcinoma.
Autorzy :
Henderson YC; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Mohamed ASR; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, USA.
Maniakas A; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Université de Montréal, Hôpital Maisonneuve-Rosemont, Montreal, QB, Canada.
Chen Y; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Powell RT; IBT High Throughput Screening Core, Texas A&M Health Science Center, Houston, TX, USA.
Peng S; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cardenas M; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Williams MD; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bell D; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zafereo ME; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wang RJ; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Scherer SE; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Wheeler DA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Cabanillas ME; Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hofmann MC; Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Johnson FM; MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences, Houston, TX, USA.; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Stephan CC; IBT High Throughput Screening Core, Texas A&M Health Science Center, Houston, TX, USA.
Sandulache V; Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
Lai SY; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Cellular and Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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Źródło :
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2021 Sep 27; Vol. 106 (10), pp. 2962-2978.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Screening Assays*
Antineoplastic Agents/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Thyroid Carcinoma, Anaplastic/*drug therapy
Thyroid Neoplasms/*drug therapy
Animals ; Carcinogenicity Tests ; Cell Line, Tumor ; Disease Models, Animal ; Humans ; Proto-Oncogene Proteins B-raf/drug effects ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
High throughput screening of fiber-based adsorbents for material and process development.
Autorzy :
Winderl J; Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany. Electronic address: .
Bürkle S; Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany. Electronic address: .
Hubbuch J; Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Sep 13; Vol. 1653, pp. 462387. Date of Electronic Publication: 2021 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal*/isolation & purification
Chromatography, Liquid*
High-Throughput Screening Assays*
Materials Science*/methods
Cation Exchange Resins/chemistry
Czasopismo naukowe
Tytuł :
High-throughput protein modification quantitation analysis using intact protein MRM and its application on hENGase inhibitor screening.
Autorzy :
Tao D; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA. Electronic address: .
Xu M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Farkhondeh A; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Burns AP; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
Rodems S; Traverse Therapeutics, San Diego, CA, 92130, USA.
Might M; University of Alabama at Birmingham, Birmingham, AL, 35210, USA.
Zheng W; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.
LeClair CA; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA. Electronic address: .
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Źródło :
Talanta [Talanta] 2021 Aug 15; Vol. 231, pp. 122384. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
Tandem Mass Spectrometry*
Humans
Czasopismo naukowe
Tytuł :
[Advances of high-throughput screening system in reengineering of biological entities].
Autorzy :
Yang J; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Su X; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.; University of Science and Technology of China, Hefei 230026, Anhui, China.
Zhu L; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
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Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2021 Jul 25; Vol. 37 (7), pp. 2197-2210.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Directed Molecular Evolution*
High-Throughput Screening Assays*
Biotechnology ; Enzymes ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
InstaDock: A single-click graphical user interface for molecular docking-based virtual high-throughput screening.
Autorzy :
Mohammad T; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Mathur Y; Department of Computer Science, Jamia Millia Islamia, New Delhi, India.
Hassan MI; Royal Society of Biology, UK, and fellow of Royal Society of Chemistry, UK.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Jul 20; Vol. 22 (4).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Algorithms*
Drug Design*
High-Throughput Screening Assays*
Molecular Docking Simulation*
User-Computer Interface*
Proteins/*chemistry
Drug Evaluation, Preclinical ; Humans ; Proteins/metabolism
Czasopismo naukowe
Tytuł :
Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen.
Autorzy :
Bunch TA; Department of Cellular & Molecular Medicine, University of Arizona, Tucson Arizona, USA.
Guhathakurta P; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Lepak VC; Department of Cellular & Molecular Medicine, University of Arizona, Tucson Arizona, USA.
Thompson AR; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Kanassatega RS; Department of Cellular & Molecular Medicine, University of Arizona, Tucson Arizona, USA.
Wilson A; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Thomas DD; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.
Colson BA; Department of Cellular & Molecular Medicine, University of Arizona, Tucson Arizona, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100840. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Screening Assays*
Actins/*metabolism
Carrier Proteins/*metabolism
Myocardium/*metabolism
Actins/chemistry ; Animals ; Biosensing Techniques ; Calorimetry ; Fluorescence ; Fluorescence Resonance Energy Transfer ; Humans ; Protein Binding ; Rabbits ; Sarcomeres/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
A technology of a different sort: microraft arrays.
Autorzy :
Cortés-Llanos B; Department of Bioengineering, University of Washington, Seattle, WA, USA. .
Wang Y
Sims CE
Allbritton NL
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Źródło :
Lab on a chip [Lab Chip] 2021 Sep 07; Vol. 21 (17), pp. 3204-3218. Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
High-Throughput Screening Assays*
Technology*
Cell Movement ; Cell Separation ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Implementation of an efficient SARS-CoV-2 specimen pooling strategy for high throughput diagnostic testing.
Autorzy :
Singh L; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa. .
Anyaneji UJ; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Ndifon W; African Institute for Mathematical Sciences, The Next Einstein Initiative, Kigali, Rwanda. .
Turok N; Higgs Centre for Theoretical Physics, School of Physics and Astronomy, University of Edinburgh, Edinburgh, UK.
Mattison SA; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Lessells R; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Sinayskiy I; School of Chemistry and Physics, University of Kwa-Zulu Natal, Westville, South Africa.; National Institute for Theoretical and Computational Sciences (NITheCS), KwaZulu-Natal, South Africa.
San EJ; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Tegally H; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Barnett S; Discipline of Electrical, Electronic and Computer Engineering, University of KwaZulu-Natal, Durban, South Africa.
Lorimer T; Discipline of Electrical, Electronic and Computer Engineering, University of KwaZulu-Natal, Durban, South Africa.
Petruccione F; School of Chemistry and Physics, University of Kwa-Zulu Natal, Westville, South Africa.; National Institute for Theoretical and Computational Sciences (NITheCS), KwaZulu-Natal, South Africa.
de Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa. .
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Źródło :
Scientific reports [Sci Rep] 2021 Sep 07; Vol. 11 (1), pp. 17793. Date of Electronic Publication: 2021 Sep 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*diagnosis
COVID-19 Nucleic Acid Testing/*methods
High-Throughput Screening Assays/*methods
SARS-CoV-2/*isolation & purification
Specimen Handling/*methods
Antigens, Viral/isolation & purification ; Athletes ; COVID-19/blood ; COVID-19/virology ; COVID-19 Nucleic Acid Testing/economics ; COVID-19 Serological Testing/economics ; COVID-19 Serological Testing/methods ; Cost Savings ; High-Throughput Screening Assays/economics ; Humans ; RNA, Viral/isolation & purification ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Sensitivity and Specificity ; South Africa ; Specimen Handling/economics ; Sports Medicine/economics ; Sports Medicine/methods
Czasopismo naukowe
Tytuł :
Characterization of Tumor-immune Microenvironment by High-throughput Image Analysis of CD8 Immunohistochemistry Combined With Modified Masson's Trichrome.
Autorzy :
Havnar C; Department of Research Pathology, Genentech, Inc., South San Francisco, California.
Lau S; Department of Research Pathology, Genentech, Inc., South San Francisco, California.
Hung J; Department of Research Pathology, Genentech, Inc., South San Francisco, California.
Eastham-Anderson J; Department of Research Pathology, Genentech, Inc., South San Francisco, California.
Espiritu C; Department of Research Pathology, Genentech, Inc., South San Francisco, California.
Rangell L; Department of Research Pathology, Genentech, Inc., South San Francisco, California.
Koeppen H; Department of Research Pathology, Genentech, Inc., South San Francisco, California.
Ziai J; Department of Research Pathology, Genentech, Inc., South San Francisco, California.
Foreman O; Department of Research Pathology, Genentech, Inc., South San Francisco, California.
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Źródło :
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society [J Histochem Cytochem] 2021 Sep; Vol. 69 (9), pp. 611-615. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
CD8 Antigens/*analysis
Algorithms ; Animals ; Humans ; Immunohistochemistry ; Mice ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
High-Throughput Affinity Selection Mass Spectrometry Using SAMDI-MS to Identify Small-Molecule Binders of the Human Rhinovirus 3C Protease.
Autorzy :
Scholle MD; SAMDI Tech, Inc., Chicago, IL, USA.
McLaughlin D; MoMa Therapeutics, Boston, MA, USA.
Gurard-Levin ZA; SAMDI Tech, Inc., Chicago, IL, USA.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Sep; Vol. 26 (8), pp. 974-983. Date of Electronic Publication: 2021 Jun 19.
Typ publikacji :
Journal Article
MeSH Terms :
High-Throughput Screening Assays*
COVID-19/*drug therapy
Rhinovirus/*drug effects
Small Molecule Libraries/*chemistry
3C Viral Proteases/chemistry ; COVID-19/virology ; Drug Discovery ; Humans ; Ligands ; Mass Spectrometry ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; Small Molecule Libraries/isolation & purification ; Small Molecule Libraries/therapeutic use
Czasopismo naukowe
Tytuł :
High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
Autorzy :
Newman H; School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K.; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K.
Krajnc A; Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, U.K.
Bellini D; School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K.
Eyermann CJ; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa.
Boyle GA; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa.
Paterson NG; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K.
McAuley KE; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K.
Lesniak R; Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, U.K.
Gangar M; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa.
von Delft F; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K.; Structural Genomics Consortium (SGC), University of Oxford, Oxford, U.K.; Department of Biochemistry, University of Johannesburg, Auckland Park 2006, South Africa.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, U.K.
Brem J; Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, U.K.
Chibale K; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa.
Schofield CJ; Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, U.K.
Dowson CG; School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Aug 12; Vol. 64 (15), pp. 11379-11394. Date of Electronic Publication: 2021 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
High-Throughput Screening Assays*
Anti-Bacterial Agents/*pharmacology
Boron Compounds/*pharmacology
Penicillin-Binding Proteins/*antagonists & inhibitors
Pseudomonas aeruginosa/*drug effects
beta-Lactamase Inhibitors/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Binding Sites/drug effects ; Boron Compounds/chemical synthesis ; Boron Compounds/chemistry ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Penicillin-Binding Proteins/metabolism ; Structure-Activity Relationship ; beta-Lactamase Inhibitors/chemical synthesis ; beta-Lactamase Inhibitors/chemistry ; beta-Lactamases
Czasopismo naukowe

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