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Tytuł :
Changes in Dopamine Signalling Do Not Underlie Aberrant Hippocampal Plasticity in a Mouse Model of Huntington's Disease.
Autorzy :
Dallérac GM; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK. .; CIRB, CNRS UMR 7241, INSERM U1050, Collège de France, 75005, Paris, France. .
Cummings DM; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK.; University College London, Neuroscience, Physiology and Pharmacology, Gower Street, London, WC1E 6BT, UK.
Hirst MC; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK.
Milnerwood AJ; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK.; Department of Neurology & Centre for Applied Neurogenetics, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2255, Wesbrook Mall, Vancouver, V6T 1Z3, Canada.
Murphy KP; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK. .
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Źródło :
Neuromolecular medicine [Neuromolecular Med] 2016 Mar; Vol. 18 (1), pp. 146-53. Date of Electronic Publication: 2016 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuronal Plasticity*
Dopamine/*physiology
Hippocampus/*physiopathology
Huntington Disease/*physiopathology
Animals ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/metabolism ; Long-Term Synaptic Depression ; Male ; Mice ; Mice, Transgenic ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/metabolism ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.
Autorzy :
Wu D; Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK.
Cerutti C; Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK.
Lopez-Ramirez MA; 1] Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK [2] Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Pryce G; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
King-Robson J; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Simpson JE; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
van der Pol SM; Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Hirst MC; Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK.
de Vries HE; Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Sharrack B; Department of Neurology, Sheffield Teaching Hospitals NHS Trust, University of Sheffield, Sheffield, UK.
Baker D; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Male DK; Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK.
Michael GJ; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Romero IA; Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2015 Mar; Vol. 35 (3), pp. 412-23. Date of Electronic Publication: 2014 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Encephalomyelitis, Autoimmune, Experimental/*genetics
Endothelial Cells/*metabolism
MicroRNAs/*metabolism
Multiple Sclerosis/*genetics
NF-kappa B/*metabolism
T-Lymphocytes/*cytology
Adult ; Aged ; Aged, 80 and over ; Animals ; Cell Adhesion/genetics ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Inflammation ; Laser Capture Microdissection ; Male ; Mice ; Middle Aged ; Multiple Sclerosis/immunology ; Multiple Sclerosis/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; T-Lymphocytes/immunology ; Transfection
Czasopismo naukowe
Tytuł :
Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels.
Autorzy :
Dallérac GM; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK.
Levasseur G
Vatsavayai SC
Milnerwood AJ
Cummings DM
Kraev I
Huetz C
Evans KA
Walters SW
Rezaie P
Cho Y
Hirst MC
Murphy KP
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Źródło :
Neuro-degenerative diseases [Neurodegener Dis] 2015; Vol. 15 (2), pp. 93-108. Date of Electronic Publication: 2015 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*pathology
Dopaminergic Neurons/*physiology
Huntington Disease/*pathology
Small-Conductance Calcium-Activated Potassium Channels/*metabolism
Animals ; Biophysical Phenomena/genetics ; Disease Models, Animal ; Dopamine/metabolism ; Electric Stimulation ; Female ; Gene Expression Regulation/genetics ; Humans ; Huntingtin Protein ; Huntington Disease/genetics ; In Vitro Techniques ; Male ; Membrane Potentials/genetics ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Trinucleotide Repeat Expansion/genetics ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation.
Autorzy :
Lopez-Ramirez MA; Department of Life, Health, and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK;
Wu D; Department of Life, Health, and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK;
Pryce G; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;
Simpson JE; Sheffield Institute for Translational Neuroscience and.
Reijerkerk A; Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
King-Robson J; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;
Kay O; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;
de Vries HE; Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Hirst MC; Department of Life, Health, and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK;
Sharrack B; Department of Neurology, Sheffield Teaching Hospitals National Health Service (NHS) Trust, University of Sheffield, Sheffield, UK; and.
Baker D; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;
Male DK; Department of Life, Health, and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK;
Michael GJ; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;
Romero IA; Department of Life, Health, and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK; .
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2014 Jun; Vol. 28 (6), pp. 2551-65. Date of Electronic Publication: 2014 Mar 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*physiology
MicroRNAs/*physiology
Animals ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/physiopathology ; Humans ; Male ; Mice ; Multiple Sclerosis ; Talin/biosynthesis ; Transcriptome ; Up-Regulation ; Vinculin/biosynthesis
Czasopismo naukowe
Tytuł :
Impaired long-term potentiation in the prefrontal cortex of Huntington's disease mouse models: rescue by D1 dopamine receptor activation.
Autorzy :
Dallérac GM; Huntington's Disease Research Forum, Department of Life Sciences, The Open University, Milton Keynes, UK.
Vatsavayai SC
Cummings DM
Milnerwood AJ
Peddie CJ
Evans KA
Walters SW
Rezaie P
Hirst MC
Murphy KP
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Źródło :
Neuro-degenerative diseases [Neurodegener Dis] 2011; Vol. 8 (4), pp. 230-9. Date of Electronic Publication: 2011 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntington Disease/*physiopathology
Long-Term Potentiation/*physiology
Prefrontal Cortex/*physiopathology
Receptors, Dopamine D1/*metabolism
Animals ; Disease Models, Animal ; Dopamine Agonists/pharmacology ; Electrophysiology ; Female ; Immunohistochemistry ; Long-Term Potentiation/drug effects ; Male ; Mice ; Mice, Transgenic ; Organ Culture Techniques ; Prefrontal Cortex/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington's disease.
Autorzy :
White II, Joseph A. (AUTHOR)
Krzystek, Thomas J. (AUTHOR)
Hoffmar-Glennon, Hayley (AUTHOR)
Thant, Claire (AUTHOR)
Zimmerman, Katherine (AUTHOR)
Iacobucci, Gary (AUTHOR)
Vail, Julia (AUTHOR)
Thurston, Layne (AUTHOR)
Rahman, Saad (AUTHOR)
Gunawardena, Shermali (AUTHOR)
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Źródło :
Acta Neuropathologica Communications. 7/1/2020, Vol. 8 Issue 1, p1-22. 22p.
Czasopismo naukowe
Tytuł :
Abnormal cortical synaptic plasticity in a mouse model of Huntington's disease.
Autorzy :
Cummings DM; Huntington's Disease Research Forum, Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, UK.
Milnerwood AJ
Dallérac GM
Vatsavayai SC
Hirst MC
Murphy KP
Pokaż więcej
Źródło :
Brain research bulletin [Brain Res Bull] 2007 Apr 30; Vol. 72 (2-3), pp. 103-7. Date of Electronic Publication: 2006 Nov 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Cortex/*physiopathology
Excitatory Postsynaptic Potentials/*physiology
Huntington Disease/*physiopathology
Long-Term Synaptic Depression/*physiology
Animals ; Disease Models, Animal ; Huntington Disease/complications ; Memory Disorders/etiology ; Mice ; Microelectrodes ; Organ Culture Techniques ; Synapses/pathology
Czasopismo naukowe
Tytuł :
Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset.
Autorzy :
Vatsavayai SC; Huntington's Disease Research Forum, Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, UK.
Dallérac GM
Milnerwood AJ
Cummings DM
Rezaie P
Murphy KP
Hirst MC
Pokaż więcej
Źródło :
Brain research bulletin [Brain Res Bull] 2007 Apr 30; Vol. 72 (2-3), pp. 98-102. Date of Electronic Publication: 2006 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Mice*
Brain/*metabolism
Huntington Disease/*genetics
Animals ; Brain/pathology ; Genotype ; Huntingtin Protein ; Immunohistochemistry ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Phenotype ; Polymerase Chain Reaction ; Trinucleotide Repeat Expansion
Czasopismo naukowe
Tytuł :
Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease.
Autorzy :
Cummings DM; Huntington's Disease Research Forum, Department of Biological Sciences, Open University, Milton Keynes, UK.
Milnerwood AJ
Dallérac GM
Waights V
Brown JY
Vatsavayai SC
Hirst MC
Murphy KP
Pokaż więcej
Źródło :
Human molecular genetics [Hum Mol Genet] 2006 Oct 01; Vol. 15 (19), pp. 2856-68. Date of Electronic Publication: 2006 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopamine/*physiology
Huntington Disease/*physiopathology
Neuronal Plasticity/*physiology
Animals ; Cerebral Cortex/physiopathology ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein ; Huntington Disease/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Receptors, Dopamine/metabolism ; Synaptic Transmission
Czasopismo naukowe

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