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Wyświetlanie 1-58 z 58
Tytuł :
Changes in Dopamine Signalling Do Not Underlie Aberrant Hippocampal Plasticity in a Mouse Model of Huntington's Disease.
Autorzy :
Dallérac GM; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK. .; CIRB, CNRS UMR 7241, INSERM U1050, Collège de France, 75005, Paris, France. .
Cummings DM; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK.; University College London, Neuroscience, Physiology and Pharmacology, Gower Street, London, WC1E 6BT, UK.
Hirst MC; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK.
Milnerwood AJ; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK.; Department of Neurology & Centre for Applied Neurogenetics, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2255, Wesbrook Mall, Vancouver, V6T 1Z3, Canada.
Murphy KP; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK76AA, UK. .
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Źródło :
Neuromolecular medicine [Neuromolecular Med] 2016 Mar; Vol. 18 (1), pp. 146-53. Date of Electronic Publication: 2016 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuronal Plasticity*
Dopamine/*physiology
Hippocampus/*physiopathology
Huntington Disease/*physiopathology
Animals ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/metabolism ; Long-Term Synaptic Depression ; Male ; Mice ; Mice, Transgenic ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/metabolism ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.
Autorzy :
Wu D; Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK.
Cerutti C; Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK.
Lopez-Ramirez MA; 1] Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK [2] Department of Medicine, University of California, San Diego, La Jolla, California, USA.
Pryce G; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
King-Robson J; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Simpson JE; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
van der Pol SM; Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Hirst MC; Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK.
de Vries HE; Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Sharrack B; Department of Neurology, Sheffield Teaching Hospitals NHS Trust, University of Sheffield, Sheffield, UK.
Baker D; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Male DK; Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK.
Michael GJ; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Romero IA; Department of Life, Health and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2015 Mar; Vol. 35 (3), pp. 412-23. Date of Electronic Publication: 2014 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Encephalomyelitis, Autoimmune, Experimental/*genetics
Endothelial Cells/*metabolism
MicroRNAs/*metabolism
Multiple Sclerosis/*genetics
NF-kappa B/*metabolism
T-Lymphocytes/*cytology
Adult ; Aged ; Aged, 80 and over ; Animals ; Cell Adhesion/genetics ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Inflammation ; Laser Capture Microdissection ; Male ; Mice ; Middle Aged ; Multiple Sclerosis/immunology ; Multiple Sclerosis/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; T-Lymphocytes/immunology ; Transfection
Czasopismo naukowe
Tytuł :
Dysfunctional Dopaminergic Neurones in Mouse Models of Huntington's Disease: A Role for SK3 Channels.
Autorzy :
Dallérac GM; Huntington's Disease Research Forum, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK.
Levasseur G
Vatsavayai SC
Milnerwood AJ
Cummings DM
Kraev I
Huetz C
Evans KA
Walters SW
Rezaie P
Cho Y
Hirst MC
Murphy KP
Pokaż więcej
Źródło :
Neuro-degenerative diseases [Neurodegener Dis] 2015; Vol. 15 (2), pp. 93-108. Date of Electronic Publication: 2015 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*pathology
Dopaminergic Neurons/*physiology
Huntington Disease/*pathology
Small-Conductance Calcium-Activated Potassium Channels/*metabolism
Animals ; Biophysical Phenomena/genetics ; Disease Models, Animal ; Dopamine/metabolism ; Electric Stimulation ; Female ; Gene Expression Regulation/genetics ; Humans ; Huntingtin Protein ; Huntington Disease/genetics ; In Vitro Techniques ; Male ; Membrane Potentials/genetics ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Trinucleotide Repeat Expansion/genetics ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Tytuł :
MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation.
Autorzy :
Lopez-Ramirez MA; Department of Life, Health, and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK;
Wu D; Department of Life, Health, and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK;
Pryce G; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;
Simpson JE; Sheffield Institute for Translational Neuroscience and.
Reijerkerk A; Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
King-Robson J; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;
Kay O; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;
de Vries HE; Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.
Hirst MC; Department of Life, Health, and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK;
Sharrack B; Department of Neurology, Sheffield Teaching Hospitals National Health Service (NHS) Trust, University of Sheffield, Sheffield, UK; and.
Baker D; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;
Male DK; Department of Life, Health, and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK;
Michael GJ; Center for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK;
Romero IA; Department of Life, Health, and Chemical Sciences, Biomedical Research Network, The Open University, Milton Keynes, UK; .
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2014 Jun; Vol. 28 (6), pp. 2551-65. Date of Electronic Publication: 2014 Mar 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*physiology
MicroRNAs/*physiology
Animals ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/physiopathology ; Humans ; Male ; Mice ; Multiple Sclerosis ; Talin/biosynthesis ; Transcriptome ; Up-Regulation ; Vinculin/biosynthesis
Czasopismo naukowe
Tytuł :
Impaired long-term potentiation in the prefrontal cortex of Huntington's disease mouse models: rescue by D1 dopamine receptor activation.
Autorzy :
Dallérac GM; Huntington's Disease Research Forum, Department of Life Sciences, The Open University, Milton Keynes, UK.
Vatsavayai SC
Cummings DM
Milnerwood AJ
Peddie CJ
Evans KA
Walters SW
Rezaie P
Hirst MC
Murphy KP
Pokaż więcej
Źródło :
Neuro-degenerative diseases [Neurodegener Dis] 2011; Vol. 8 (4), pp. 230-9. Date of Electronic Publication: 2011 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Huntington Disease/*physiopathology
Long-Term Potentiation/*physiology
Prefrontal Cortex/*physiopathology
Receptors, Dopamine D1/*metabolism
Animals ; Disease Models, Animal ; Dopamine Agonists/pharmacology ; Electrophysiology ; Female ; Immunohistochemistry ; Long-Term Potentiation/drug effects ; Male ; Mice ; Mice, Transgenic ; Organ Culture Techniques ; Prefrontal Cortex/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
Abnormal cortical synaptic plasticity in a mouse model of Huntington's disease.
Autorzy :
Cummings DM; Huntington's Disease Research Forum, Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, UK.
Milnerwood AJ
Dallérac GM
Vatsavayai SC
Hirst MC
Murphy KP
Pokaż więcej
Źródło :
Brain research bulletin [Brain Res Bull] 2007 Apr 30; Vol. 72 (2-3), pp. 103-7. Date of Electronic Publication: 2006 Nov 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebral Cortex/*physiopathology
Excitatory Postsynaptic Potentials/*physiology
Huntington Disease/*physiopathology
Long-Term Synaptic Depression/*physiology
Animals ; Disease Models, Animal ; Huntington Disease/complications ; Memory Disorders/etiology ; Mice ; Microelectrodes ; Organ Culture Techniques ; Synapses/pathology
Czasopismo naukowe
Tytuł :
Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset.
Autorzy :
Vatsavayai SC; Huntington's Disease Research Forum, Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, UK.
Dallérac GM
Milnerwood AJ
Cummings DM
Rezaie P
Murphy KP
Hirst MC
Pokaż więcej
Źródło :
Brain research bulletin [Brain Res Bull] 2007 Apr 30; Vol. 72 (2-3), pp. 98-102. Date of Electronic Publication: 2006 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Mice*
Brain/*metabolism
Huntington Disease/*genetics
Animals ; Brain/pathology ; Genotype ; Huntingtin Protein ; Immunohistochemistry ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Phenotype ; Polymerase Chain Reaction ; Trinucleotide Repeat Expansion
Czasopismo naukowe
Tytuł :
Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington's disease.
Autorzy :
Cummings DM; Huntington's Disease Research Forum, Department of Biological Sciences, Open University, Milton Keynes, UK.
Milnerwood AJ
Dallérac GM
Waights V
Brown JY
Vatsavayai SC
Hirst MC
Murphy KP
Pokaż więcej
Źródło :
Human molecular genetics [Hum Mol Genet] 2006 Oct 01; Vol. 15 (19), pp. 2856-68. Date of Electronic Publication: 2006 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dopamine/*physiology
Huntington Disease/*physiopathology
Neuronal Plasticity/*physiology
Animals ; Cerebral Cortex/physiopathology ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein ; Huntington Disease/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nuclear Proteins/genetics ; Receptors, Dopamine/metabolism ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
The cloning of FRAXF: trinucleotide repeat expansion and methylation at a third fragile site in distal Xqter.
Autorzy :
Ritchie RJ; Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Knight SJ
Hirst MC
Grewal PK
Bobrow M
Cross GS
Davies KE
Pokaż więcej
Źródło :
Human molecular genetics [Hum Mol Genet] 1994 Dec; Vol. 3 (12), pp. 2115-21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Fragility*
Repetitive Sequences, Nucleic Acid*
Fragile X Syndrome/*genetics
X Chromosome/*genetics
Base Sequence ; Case-Control Studies ; Chromosome Fragile Sites ; Cloning, Molecular ; Female ; Fragile X Syndrome/metabolism ; Humans ; Male ; Methylation ; Molecular Sequence Data ; Oligodeoxyribonucleotides ; Restriction Mapping ; X Chromosome/metabolism
Czasopismo naukowe
Tytuł :
The identification of a third fragile site, FRAXF, in Xq27--q28 distal to both FRAXA and FRAXE.
Autorzy :
Hirst MC; Molecular Genetics Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Barnicoat A
Flynn G
Wang Q
Daker M
Buckle VJ
Davies KE
Bobrow M
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Źródło :
Human molecular genetics [Hum Mol Genet] 1993 Feb; Vol. 2 (2), pp. 197-200.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Fragility*
Fragile X Syndrome/*genetics
X Chromosome/*ultrastructure
Adolescent ; Adult ; Chromatin/ultrastructure ; Chromosome Fragile Sites ; Female ; Genetic Markers ; Humans ; In Situ Hybridization, Fluorescence ; Infant ; Male ; Pedigree
Czasopismo naukowe
Tytuł :
Identification of the FRAXE fragile site in two families ascertained for X linked mental retardation.
Autorzy :
Flynn GA; Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford.
Hirst MC
Knight SJ
Macpherson JN
Barber JC
Flannery AV
Davies KE
Buckle VJ
Pokaż więcej
Źródło :
Journal of medical genetics [J Med Genet] 1993 Feb; Vol. 30 (2), pp. 97-100.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Fragility*
X Chromosome*/drug effects
Fragile X Syndrome/*genetics
Chromosome Fragile Sites ; Chromosome Mapping ; DNA Mutational Analysis ; DNA Probes ; Folic Acid/pharmacology ; Genetic Linkage ; Humans ; In Situ Hybridization, Fluorescence ; In Vitro Techniques ; Male ; Phenotype ; Repetitive Sequences, Nucleic Acid
Czasopismo naukowe
Tytuł :
A microdeletion of less than 250 kb, including the proximal part of the FMR-I gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome.
Autorzy :
Wöhrle D; Abteilung Klinische Genetik, Universität Ulm, Germany.
Kotzot D
Hirst MC
Manca A
Korn B
Schmidt A
Barbi G
Rott HD
Poustka A
Davies KE
et. al.
Pokaż więcej
Źródło :
American journal of human genetics [Am J Hum Genet] 1992 Aug; Vol. 51 (2), pp. 299-306.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Deletion*
RNA-Binding Proteins*
Fragile X Syndrome/*genetics
Nerve Tissue Proteins/*genetics
Base Sequence ; Child ; DNA ; DNA Probes ; Female ; Fragile X Mental Retardation Protein ; Humans ; Male ; Molecular Sequence Data ; Nucleic Acid Hybridization ; Phenotype ; Polymerase Chain Reaction ; RNA, Messenger/analysis ; Restriction Mapping
Czasopismo naukowe
Tytuł :
Genotype mosaicism in fragile X fetal tissues.
Autorzy :
Wöhrle D; Abteilung Klinische Genetik der Universität, Ulm, Federal Republic of Germany.
Hirst MC
Kennerknecht I
Davies KE
Steinbach P
Pokaż więcej
Źródło :
Human genetics [Hum Genet] 1992 Apr; Vol. 89 (1), pp. 114-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Restriction Fragment Length*
Fetal Diseases/*genetics
Fragile X Syndrome/*genetics
Mosaicism/*genetics
Repetitive Sequences, Nucleic Acid/*genetics
Blotting, Southern ; Female ; Fetus ; Humans ; Male ; Methylation ; Mutation/genetics ; Prenatal Diagnosis
Czasopismo naukowe
Tytuł :
Molecular analysis of the fragile X syndrome.
Autorzy :
Hirst MC; Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
Knight SM
Nakahori Y
Roche A
Davies KE
Pokaż więcej
Źródło :
Journal of inherited metabolic disease [J Inherit Metab Dis] 1992; Vol. 15 (4), pp. 532-8.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Fragile X Syndrome/*genetics
Chromosome Mapping ; Chromosomes, Fungal ; Gene Library ; Genome, Human ; Humans ; Male ; Methylation ; Mutation
Czasopismo naukowe
Tytuł :
Mapping of a cerebellar degeneration related protein and DXS304 around the fragile site.
Autorzy :
Hirst MC; Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, England.
Bell MV
MacKinnon RN
Watson JE
Callen D
Sutherland G
Dahl N
Patterson MN
Schwartz C
Ledbetter D
et. al.
Pokaż więcej
Źródło :
American journal of medical genetics [Am J Med Genet] 1991 Feb-Mar; Vol. 38 (2-3), pp. 354-6.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Probes*
Polymorphism, Restriction Fragment Length*
X Chromosome*
Spinocerebellar Degenerations/*genetics
Base Sequence ; Chromosome Mapping ; DNA/genetics ; Deoxyribonucleases, Type II Site-Specific ; Genetic Markers ; Humans ; Molecular Sequence Data ; Mucopolysaccharidosis II/genetics ; Pedigree
Czasopismo naukowe
Tytuł :
The c-Harvey-ras-1 oncogene in chromosome mediated gene transfer.
Autorzy :
Morten JE; MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Edinburgh, UK.
Hirst MC
Porteous DJ
Pokaż więcej
Źródło :
Anticancer research [Anticancer Res] 1987 Jul-Aug; Vol. 7 (4A), pp. 573-88.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cell Transformation, Neoplastic*
Chromosomes*
Oncogenes*
Chromosome Mapping/*methods
Proto-Oncogene Proteins/*genetics
Animals ; Humans ; Mice ; Phenotype ; Transformation, Genetic
Czasopismo naukowe
    Wyświetlanie 1-58 z 58

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