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Wyszukujesz frazę ""Histamine"" wg kryterium: Temat


Tytuł :
Cryo-EM structure of the human histamine H 1 receptor/G q complex.
Autorzy :
Xia R; Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology, Harbin, China.
Wang N; Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology, Harbin, China.
Xu Z; Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology, Harbin, China.
Lu Y; Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology, Harbin, China.
Song J; Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology, Harbin, China.
Zhang A; The HIT cryo-EM facility, Harbin Institute of Technology, Harbin, China.
Guo C; The HIT cryo-EM facility, Harbin Institute of Technology, Harbin, China.
He Y; Laboratory of Receptor Structure and Signaling, The HIT Center for Life Sciences, Harbin Institute of Technology, Harbin, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 07; Vol. 12 (1), pp. 2086. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cryoelectron Microscopy/*methods
GTP-Binding Protein alpha Subunits, Gq-G11/*chemistry
Histamine/*chemistry
Receptors, Histamine/*chemistry
Binding Sites ; GTP-Binding Protein alpha Subunits, Gq-G11/metabolism ; GTP-Binding Proteins ; Histamine/metabolism ; Humans ; Ligands ; Protein Binding ; Protein Domains ; Receptors, Histamine/metabolism ; Receptors, Histamine H1/metabolism
Czasopismo naukowe
Tytuł :
Histamine receptors and COVID-19.
Autorzy :
Ennis M; The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queens University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Tiligada K; Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, M. Asias 75, 11527, Athens, Greece. .
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Źródło :
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2021 Jan; Vol. 70 (1), pp. 67-75. Date of Electronic Publication: 2020 Nov 18.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
COVID-19/*drug therapy
Histamine Antagonists/*therapeutic use
Receptors, Histamine/*drug effects
COVID-19/metabolism ; Histamine H2 Antagonists/therapeutic use ; Humans ; Receptors, Histamine/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/metabolism
Czasopismo naukowe
Tytuł :
[Effects of Histamine and Related Compounds on the Central Nervous System].
Autorzy :
Kamei C; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women's University.; Department of Medicinal Pharmacology, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University.
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Źródło :
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2021; Vol. 141 (1), pp. 93-110.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Central Nervous System/*drug effects
Histamine/*pharmacology
Histamine H1 Antagonists/*pharmacology
Methylhistamines/*pharmacology
Methylhistidines/*pharmacology
Animals ; Avoidance Learning/drug effects ; Histamine/administration & dosage ; Histamine/metabolism ; Histamine/physiology ; Histamine H1 Antagonists/therapeutic use ; Humans ; Hypnotics and Sedatives ; Injections, Intraventricular ; Kindling, Neurologic/drug effects ; Memory Disorders/drug therapy ; Methylhistamines/administration & dosage ; Methylhistidines/administration & dosage ; Mice ; Rats ; Receptors, Histamine H3/metabolism ; Receptors, Histamine H3/physiology ; Seizures/drug therapy ; Sleep/drug effects ; Sleep Initiation and Maintenance Disorders/drug therapy
Czasopismo naukowe
Tytuł :
Potential association of mast cells with coronavirus disease 2019.
Autorzy :
Theoharides TC; Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, Massachusetts; School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts; Department of Internal Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts. Electronic address: .
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Źródło :
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2021 Mar; Vol. 126 (3), pp. 217-218. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19/*immunology
Cholecalciferol/*pharmacology
Histamine Antagonists/*pharmacology
Luteolin/*pharmacology
Mast Cells/*drug effects
COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/virology ; Cell Communication/drug effects ; Cromolyn Sodium/pharmacology ; Cyproheptadine/analogs & derivatives ; Cyproheptadine/pharmacology ; Cytokines/antagonists & inhibitors ; Cytokines/biosynthesis ; Cytokines/immunology ; Famotidine/pharmacology ; Histamine/biosynthesis ; Humans ; Lung/drug effects ; Lung/immunology ; Lung/virology ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/virology ; Mast Cells/immunology ; Mast Cells/virology ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Substance P/antagonists & inhibitors ; Substance P/pharmacology
Czasopismo naukowe
Tytuł :
Current and emerging pharmacotherapy for chronic spontaneous Urticaria: a focus on non-biological therapeutics.
Autorzy :
Hon KL; Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong & Department of Paediatrics and adolescent Medicine, the Hong Kong Children's Hospital, Shatin, Hong Kong.
Li JTS; Centre for Learning Enhancement and Research, The Chinese University of Hong Kong, Shatin, Hong Kong.
Leung AKC; Department of Pediatrics, The University of Calgary and The Alberta Children's Hospital, Calgary, Alberta, Canada.
Lee VWY; Centre for Learning Enhancement and Research, The Chinese University of Hong Kong, Shatin, Hong Kong.
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Źródło :
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2021 Mar; Vol. 22 (4), pp. 497-509. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Angioedema/*drug therapy
Chronic Urticaria/*drug therapy
Histamine Antagonists/*therapeutic use
Adrenal Cortex Hormones/therapeutic use ; Histamine H1 Antagonists/administration & dosage ; Humans ; Quality of Life
Czasopismo naukowe
Tytuł :
Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors.
Autorzy :
Zhang XY; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.; Institute for Brain Sciences, Nanjing University, Nanjing 210023, China.
Peng SY; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Shen LP; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Zhuang QX; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Li B; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China; .
Xie ST; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Li QX; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Shi MR; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Ma TY; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.
Zhang Q; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.; Institute for Brain Sciences, Nanjing University, Nanjing 210023, China.
Wang JJ; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China.; Institute for Brain Sciences, Nanjing University, Nanjing 210023, China.
Zhu JN; State Key Laboratory of Pharmaceutical Biotechnology and Department of Physiology, School of Life Sciences, Nanjing University, Nanjing 210023, China; .; Institute for Brain Sciences, Nanjing University, Nanjing 210023, China.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 15; Vol. 117 (50), pp. 32155-32164. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anxiety Disorders/*drug therapy
Histamine Agonists/*administration & dosage
Nucleus Accumbens/*physiopathology
Obsessive-Compulsive Disorder/*drug therapy
Receptors, Histamine H3/*metabolism
Afferent Pathways/drug effects ; Afferent Pathways/physiopathology ; Animals ; Anxiety Disorders/etiology ; Anxiety Disorders/physiopathology ; Anxiety Disorders/psychology ; Disease Models, Animal ; Glutamates/metabolism ; Histamine/metabolism ; Histamine H3 Antagonists/administration & dosage ; Humans ; Hypothalamic Area, Lateral/drug effects ; Hypothalamic Area, Lateral/physiopathology ; Male ; Neurons/drug effects ; Neurons/metabolism ; Nucleus Accumbens/cytology ; Nucleus Accumbens/drug effects ; Obsessive-Compulsive Disorder/etiology ; Obsessive-Compulsive Disorder/physiopathology ; Obsessive-Compulsive Disorder/psychology ; Optogenetics ; Patch-Clamp Techniques ; Prefrontal Cortex/cytology ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/physiopathology ; Presynaptic Terminals/drug effects ; Presynaptic Terminals/metabolism ; Rats ; Rats, Transgenic ; Stereotaxic Techniques ; Stress, Psychological/complications ; Stress, Psychological/psychology ; Synaptic Transmission/drug effects ; Synaptic Transmission/physiology
Czasopismo naukowe
Tytuł :
The Multi-Targeting Ligand ST-2223 with Histamine H 3 Receptor and Dopamine D 2 /D 3 Receptor Antagonist Properties Mitigates Autism-Like Repetitive Behaviors and Brain Oxidative Stress in Mice.
Autorzy :
Eissa N; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.; Zayed Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.; Department of Applied Sciences, College of Arts and Sciences, Abu Dhabi University, Al Ain P.O. Box 59911, United Arab Emirates.
Venkatachalam K; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.; Zayed Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.
Jayaprakash P; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.; Zayed Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.
Falkenstein M; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr.1, 40225 Düsseldorf, Germany.
Dubiel M; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr.1, 40225 Düsseldorf, Germany.
Frank A; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr.1, 40225 Düsseldorf, Germany.
Reiner-Link D; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr.1, 40225 Düsseldorf, Germany.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr.1, 40225 Düsseldorf, Germany.
Sadek B; Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.; Zayed Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 16; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article
MeSH Terms :
Autism Spectrum Disorder/*drug therapy
Brain/*metabolism
Dopamine D2 Receptor Antagonists/*administration & dosage
Grooming/*drug effects
Histamine H3 Antagonists/*administration & dosage
Oxidative Stress/*drug effects
Receptors, Dopamine D3/*antagonists & inhibitors
Animals ; Anxiety/drug therapy ; Brain/drug effects ; Disease Models, Animal ; Dopamine D2 Receptor Antagonists/metabolism ; HEK293 Cells ; Histamine H3 Antagonists/metabolism ; Humans ; Ligands ; Locomotion/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/metabolism ; Receptors, Histamine H3/metabolism
Czasopismo naukowe
Tytuł :
Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model.
Autorzy :
Nicoud MB; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Táquez Delgado MA; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Sarasola MP; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Vidal A; Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Speisky D; Pathology Department, British Hospital, Buenos Aires, Argentina.
Cremaschi GA; Neuroimmunomodulation and Molecular Oncology Division, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Sterle HA; Neuroimmunomodulation and Molecular Oncology Division, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
Medina VA; Laboratory of Tumour Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Jan; Vol. 70 (1), pp. 233-244. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*immunology
Breast Neoplasms/*metabolism
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Receptors, Histamine H4/*deficiency
Receptors, Histamine H4/*immunology
T-Lymphocytes, Regulatory/*immunology
Animals ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Disease Models, Animal ; Female ; Histamine/immunology ; Interleukin-2 Receptor alpha Subunit/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; T-Lymphocytes, Regulatory/metabolism ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Identification of antiviral antihistamines for COVID-19 repurposing.
Autorzy :
Reznikov LR; Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL, USA.
Norris MH; Department of Geography and the Emerging Pathogens Institute, Spatial Epidemiology and Ecology Research Laboratory, University of Florida, Gainesville, FL, USA.
Vashisht R; Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, CA, USA.
Bluhm AP; Department of Geography and the Emerging Pathogens Institute, Spatial Epidemiology and Ecology Research Laboratory, University of Florida, Gainesville, FL, USA.
Li D; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Liao YJ; Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL, USA.
Brown A; Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Butte AJ; Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, CA, USA.
Ostrov DA; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 29; Vol. 538, pp. 173-179. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Repositioning*
Angiotensin-Converting Enzyme 2/*chemistry
Antiviral Agents/*chemistry
COVID-19/*drug therapy
Histamine Antagonists/*chemistry
SARS-CoV-2/*drug effects
Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Catalytic Domain ; Chlorocebus aethiops ; HEK293 Cells ; Histamine Antagonists/pharmacology ; Histamine Antagonists/therapeutic use ; Humans ; Ligands ; Protein Binding ; Receptors, Histamine/chemistry ; Receptors, sigma/chemistry ; Vero Cells
Czasopismo naukowe
Tytuł :
Adult male patient with severe intellectual disability caused by a homozygous mutation in the HNMT gene.
Autorzy :
Verhoeven WMA; Centre of Excellence for Neuropsychiatry, Vincent Van Gogh Institute, Venray, The Netherlands .; Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands.
Egger JIM; Centre of Excellence for Neuropsychiatry, Vincent Van Gogh Institute, Venray, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Janssen PKC; Department of Hospital Pharmacy, VieCuri Medical Centre, Venlo, The Netherlands.; Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Centre, Maastricht, The Netherlands.
van Haeringen A; Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
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Źródło :
BMJ case reports [BMJ Case Rep] 2020 Dec 12; Vol. 13 (12). Date of Electronic Publication: 2020 Dec 12.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Homozygote*
Mutation*
Histamine N-Methyltransferase/*genetics
Intellectual Disability/*genetics
Aggression/physiology ; Brain/metabolism ; Histamine/metabolism ; Histamine N-Methyltransferase/metabolism ; Humans ; Hydroxyzine/therapeutic use ; Intellectual Disability/diet therapy ; Intellectual Disability/drug therapy ; Intellectual Disability/metabolism ; Male ; Sleep/physiology ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Stress Ulcer Prophylaxis for ICU Patients.
Autorzy :
Law LS; Alexandra Hospital, National University Health System, Singapore.
Lo EA; National University Hospital, National University Health System, Singapore.
Yeoh SF; National University Hospital, National University Health System, Singapore.
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Źródło :
JAMA [JAMA] 2020 Jul 07; Vol. 324 (1), pp. 101-102.
Typ publikacji :
Letter; Comment
MeSH Terms :
Histamine*
Proton Pump Inhibitors*
Histamine H2 Antagonists ; Hospital Mortality ; Humans ; Intensive Care Units ; Respiration, Artificial ; Ulcer
Opinia redakcyjna
Tytuł :
Stress Ulcer Prophylaxis for ICU Patients.
Autorzy :
Torres CM; Department of Critical Care Medicine, Johns Hopkins Hospital, Baltimore, Maryland.
Navarrete SB; Department of Critical Care Medicine, Johns Hopkins Hospital, Baltimore, Maryland.
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Źródło :
JAMA [JAMA] 2020 Jul 07; Vol. 324 (1), pp. 102.
Typ publikacji :
Letter; Comment
MeSH Terms :
Histamine*
Proton Pump Inhibitors*
Histamine H2 Antagonists ; Hospital Mortality ; Humans ; Intensive Care Units ; Respiration, Artificial ; Ulcer
Opinia redakcyjna
Tytuł :
Stress Ulcer Prophylaxis for ICU Patients.
Autorzy :
Tansel A; Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston.
Graham DY; Department of Medicine, Baylor College of Medicine, Houston, Texas.
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Źródło :
JAMA [JAMA] 2020 Jul 07; Vol. 324 (1), pp. 101.
Typ publikacji :
Letter; Comment
MeSH Terms :
Histamine*
Proton Pump Inhibitors*
Histamine H2 Antagonists ; Hospital Mortality ; Humans ; Intensive Care Units ; Respiration, Artificial ; Ulcer
Opinia redakcyjna
Tytuł :
A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes.
Autorzy :
Höring C; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.
Seibel U; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.
Tropmann K; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.
Grätz L; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.
Mönnich D; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.
Pitzl S; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.
Bernhardt G; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.
Pockes S; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.
Strasser A; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, 93040 Regensburg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 10; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
GTP-Binding Proteins/*metabolism
Receptors, Histamine/*classification
Receptors, Histamine/*metabolism
Animals ; Drug Discovery ; GTP-Binding Proteins/chemistry ; GTP-Binding Proteins/genetics ; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism ; HEK293 Cells ; Histamine Agonists/metabolism ; Histamine Antagonists/metabolism ; Humans ; Kinetics ; Ligands ; Luciferases/metabolism ; Molecular Mimicry ; Protein Conformation ; Radioligand Assay ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Histamine/chemistry ; Recombinant Proteins/chemistry ; Recombinant Proteins/classification ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Roles of Lys191 and Lys179 in regulating thermodynamic binding forces of ligands to determine their binding affinity for human histamine H 1 receptors.
Autorzy :
Kobayashi C; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Kiyose, Tokyo 204-8588, Japan.
Tanaka A; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Kiyose, Tokyo 204-8588, Japan.
Yasuda T; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Kiyose, Tokyo 204-8588, Japan.
Hishinuma S; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Kiyose, Tokyo 204-8588, Japan. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114185. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Thermodynamics*
Histamine H1 Antagonists/*metabolism
Lysine/*metabolism
Receptors, Histamine H1/*metabolism
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Dose-Response Relationship, Drug ; Histamine Antagonists/chemistry ; Histamine Antagonists/metabolism ; Histamine H1 Antagonists/chemistry ; Humans ; Ligands ; Lysine/chemistry ; Protein Binding/drug effects ; Protein Binding/physiology ; Receptors, Histamine H1/chemistry
Czasopismo naukowe
Tytuł :
Structural modifications in the distal, regulatory region of histamine H 3 receptor antagonists leading to the identification of a potent anti-obesity agent.
Autorzy :
Szczepańska K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland.
Pockes S; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany. Electronic address: .
Podlewska S; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland; Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, Kraków, 31-343, Poland.
Höring C; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Mika K; Department of Department of Pharmacological Screening, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland.
Latacz G; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland.
Bednarski M; Department of Department of Pharmacological Screening, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland.
Siwek A; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland.
Karcz T; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland.
Nagl M; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Bresinsky M; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Mönnich D; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Seibel U; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Kuder KJ; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland.
Kotańska M; Department of Department of Pharmacological Screening, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225, Duesseldorf, Germany.
Elz S; Institute of Pharmacy, Faculty of Chemistry and Pharmacy, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.
Kieć-Kononowicz K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 05; Vol. 213, pp. 113041. Date of Electronic Publication: 2020 Nov 24.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Obesity Agents/*chemical synthesis
Histamine H3 Antagonists/*chemical synthesis
Receptors, Histamine H3/*metabolism
Animals ; Anti-Obesity Agents/pharmacology ; Body Weight ; Dose-Response Relationship, Drug ; Female ; Histamine H3 Antagonists/pharmacology ; Humans ; Imidazoles/chemistry ; Ligands ; Models, Molecular ; Piperazine/chemistry ; Piperidines/chemistry ; Protein Binding ; Rats, Wistar ; Regulatory Sequences, Nucleic Acid ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Histaminergic Control of Corticostriatal Synaptic Plasticity during Early Postnatal Development.
Autorzy :
Han S; Department of Pharmacology, University of Oxford, OX1 3QT, Oxford, United Kingdom.
Márquez-Gómez R; Department of Pharmacology, University of Oxford, OX1 3QT, Oxford, United Kingdom.
Woodman M; Department of Pharmacology, University of Oxford, OX1 3QT, Oxford, United Kingdom.
Ellender T; Department of Pharmacology, University of Oxford, OX1 3QT, Oxford, United Kingdom .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Aug 19; Vol. 40 (34), pp. 6557-6571. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neuronal Plasticity*
Cerebral Cortex/*growth & development
Cerebral Cortex/*physiology
Corpus Striatum/*growth & development
Corpus Striatum/*physiology
Histamine/*physiology
Receptors, Histamine/*physiology
Animals ; Corpus Striatum/drug effects ; Female ; Histamine/administration & dosage ; Male ; Membrane Potentials ; Mice, Inbred C57BL ; Neural Pathways/growth & development ; Neural Pathways/physiology ; Receptors, Histamine H1/physiology ; Receptors, Histamine H2/physiology ; Receptors, Histamine H3/physiology ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Histamine receptors mediate contraction of reticular groove smooth muscle of adult goats.
Autorzy :
Aneesha VA; Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, India.
Gopi RP; Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, India.
Kumawat S; Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, India.
Susanth VS; Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, India.
Vineetha S; Division of Pathology, Indian Veterinary Research Institute, Izatnagar, India.
Kumar D; Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, India.
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Źródło :
Anatomia, histologia, embryologia [Anat Histol Embryol] 2020 Jul; Vol. 49 (4), pp. 440-450. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Goats/*metabolism
Histamine/*metabolism
Muscle, Smooth/*physiology
Receptors, Histamine/*physiology
Stomach, Ruminant/*physiology
Animals ; Blotting, Western ; Cimetidine/pharmacology ; Cyproheptadine/pharmacology ; Dose-Response Relationship, Drug ; Goats/anatomy & histology ; Histamine H1 Antagonists/pharmacology ; Histamine H2 Antagonists/pharmacology ; Immunohistochemistry ; Muscle Contraction/drug effects ; Muscle Contraction/physiology ; Pyrilamine/pharmacology ; Receptors, Histamine/classification ; Stomach, Ruminant/anatomy & histology
Czasopismo naukowe
Tytuł :
Histamine H 3 Receptor Function Biases Excitatory Gain in the Nucleus Accumbens.
Autorzy :
Manz KM; Medical Scientist Training Program, Vanderbilt University, Nashville, Tennessee; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Becker JC; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Grueter CA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Grueter BA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, Tennessee; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: .
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Źródło :
Biological psychiatry [Biol Psychiatry] 2021 Mar 15; Vol. 89 (6), pp. 588-599. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Histamine*
Nucleus Accumbens*/metabolism
Animals ; Bias ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Dopamine D1/metabolism ; Synapses/metabolism
Czasopismo naukowe

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