Temat: "Histamine" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Histamine H 1 Receptor-Mediated JNK Phosphorylation Is Regulated by G q Protein-Dependent but Arrestin-Independent Pathways.
Autorzy:: Michinaga S; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Nagata A; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Ogami R; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Ogawa Y; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
Hishinuma S; Department of Pharmacodynamics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 17; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 17.
Typ publikacji:: Journal Article
MeSH Terms:: Arrestin*/metabolism
Histamine*/pharmacology
Histamine*/metabolism
Animals ; Cricetinae ; Humans ; Arrestins/metabolism ; beta-Arrestins/metabolism ; CHO Cells ; Clathrin/metabolism ; Cricetulus ; Extracellular Signal-Regulated MAP Kinases/metabolism ; G-Protein-Coupled Receptor Kinases/metabolism ; GTP-Binding Proteins/metabolism ; Phosphorylation ; Protein Kinase C/metabolism ; Receptors, Histamine H1/genetics ; Receptors, Histamine H1/metabolism ; Signal Transduction

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Skocz do pozycji: 2.

Tytuł:: Effect of histamine-receptor antagonism on the circulating inflammatory cell and cytokine response to exercise: A pilot study.
Autorzy:: Ely MR; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Mangum JE; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Needham KW; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Minson CT; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Halliwill JR; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.; Pokaż więcej
Źródło:: Physiological reports [Physiol Rep] 2024 Feb; Vol. 12 (3), pp. e15936.
Typ publikacji:: Randomized Controlled Trial; Journal Article
MeSH Terms:: Histamine*
Cytokines*
Humans ; Pilot Projects ; Exercise/physiology ; Histamine H2 Antagonists/pharmacology

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Skocz do pozycji: 3.

Tytuł:: Recovery of the histamine H 3 receptor activity lost in yeast cells through error-prone PCR and in vivo selection.
Autorzy:: Watanabe A; Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo, 125-8585, Japan.
Nakajima A; Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo, 125-8585, Japan.
Shiroishi M; Department of Biological Science and Technology, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo, 125-8585, Japan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Sep 26; Vol. 13 (1), pp. 16127. Date of Electronic Publication: 2023 Sep 26.
Typ publikacji:: Journal Article
MeSH Terms:: Saccharomyces cerevisiae*/genetics
Saccharomyces cerevisiae*/metabolism
Receptors, Histamine H3*/genetics
Receptors, Histamine H3*/metabolism
Animals ; Humans ; Histamine/metabolism ; Mammals/metabolism ; Polymerase Chain Reaction ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Receptors, Histamine/genetics ; Receptors, Histamine/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism

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Skocz do pozycji: 4.

Tytuł:: Stabilizing histamine release in gut mast cells mitigates peripheral and central inflammation after stroke.
Autorzy:: Conesa MPB; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Blixt FW; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Peesh P; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Khan R; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Korf J; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Lee J; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Jagadeesan G; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Andersohn A; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Das TK; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Tan C; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Di Gesu C; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Colpo GD; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Moruno-Manchón JF; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
McCullough LD; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Bryan R; Department of Anesthesiology, Baylor College of Medicine, Houston, TX, USA.
Ganesh BP; Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA. .; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2023 Oct 07; Vol. 20 (1), pp. 230. Date of Electronic Publication: 2023 Oct 07.
Typ publikacji:: Journal Article
MeSH Terms:: Histamine Release*
Stroke*/complications
Humans ; Mice ; Male ; Animals ; Mast Cells ; Cromolyn Sodium/pharmacology ; Cromolyn Sodium/therapeutic use ; Histamine ; Neuroinflammatory Diseases ; Inflammation/drug therapy ; Inflammation/etiology ; Infarction, Middle Cerebral Artery/complications ; Infarction, Middle Cerebral Artery/drug therapy ; Ischemia

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Skocz do pozycji: 5.

Tytuł:: Trisubstituted 1,3,5-Triazines as Histamine H 4 Receptor Antagonists with Promising Activity In Vivo.
Autorzy:: Olejarz-Maciej A; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Mogilski S; Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Karcz T; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Werner T; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Kamińska K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Kupczyk J; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Honkisz-Orzechowska E; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Latacz G; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.
Kieć-Kononowicz K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Łażewska D; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 May 19; Vol. 28 (10). Date of Electronic Publication: 2023 May 19.
Typ publikacji:: Journal Article
MeSH Terms:: Histamine*
Triazines*/pharmacology
Triazines*/therapeutic use
Humans ; Receptors, Histamine H4 ; Receptors, Histamine ; Pain/drug therapy ; Ligands ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Receptors, G-Protein-Coupled

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Skocz do pozycji: 6.

Tytuł:: Computational Analysis of Histamine Protonation Effects on H 1 R Binding.
Autorzy:: Conrad M; Division of Bioinformatics, Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Horn AHC; Division of Bioinformatics, Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.; Erlangen National High Performance Computing Center (NHR@FAU), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91058 Erlangen, Germany.
Sticht H; Division of Bioinformatics, Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.; Erlangen National High Performance Computing Center (NHR@FAU), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91058 Erlangen, Germany.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Apr 27; Vol. 28 (9). Date of Electronic Publication: 2023 Apr 27.
Typ publikacji:: Journal Article
MeSH Terms:: Histamine*/metabolism
Receptors, Histamine H1*/chemistry
Receptors, Histamine H1*/metabolism
Histamine Agonists/pharmacology ; Receptors, Histamine H2 ; GTP-Binding Proteins/metabolism

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Skocz do pozycji: 7.

Tytuł:: Evaluation of Some Safety Parameters of Dual Histamine H 3 and Sigma-2 Receptor Ligands with Anti-Obesity Potential.
Autorzy:: Mika K; Department of Pharmacological Screening, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.
Szafarz M; Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.
Bednarski M; Department of Pharmacological Screening, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.
Siwek A; Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.
Szczepańska K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.; Department of Medicinal Chemistry, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12, 31-343 Cracow, Poland.
Kieć-Kononowicz K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.
Kotańska M; Department of Pharmacological Screening, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Apr 19; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 19.
Typ publikacji:: Journal Article
MeSH Terms:: Histamine H3 Antagonists*/pharmacology
Receptors, Histamine H3*
Humans ; Animals ; Histamine ; Obesity/drug therapy ; Weight Gain ; Ligands ; Histamine Antagonists

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Skocz do pozycji: 8.

Tytuł:: Multitargeting Histamine H 3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives.
Autorzy:: Łażewska D; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Kaleta M; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Zaręba P; Department of Physicochemical Drug Analysis, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Godyń J; Department of Physicochemical Drug Analysis, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Dubiel M; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Düuesseldorf, Germany.
Honkisz-Orzechowska E; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Doroz-Płonka A; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Więckowska A; Department of Physicochemical Drug Analysis, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstr. 1, 40225 Düuesseldorf, Germany.
Kieć-Kononowicz K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Mar 03; Vol. 28 (5). Date of Electronic Publication: 2023 Mar 03.
Typ publikacji:: Journal Article
MeSH Terms:: Receptors, Histamine H3*/chemistry
Neuroblastoma*
Alzheimer Disease*/drug therapy
Humans ; Histamine ; Acetylcholinesterase/metabolism ; Structure-Activity Relationship ; Drug Inverse Agonism ; Cholinesterase Inhibitors/chemistry ; Receptors, Histamine ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/pharmacology ; Ligands

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Skocz do pozycji: 9.

Tytuł:: Antiseizure Properties of Histamine H 3 Receptor Antagonists Belonging 3,4-Dihydroquinolin-2(1 H )-Ones.
Autorzy:: Hua Y; Health Science Center, Jinggangshan University, Ji'an 343009, China.
Song M; Health Science Center, Jinggangshan University, Ji'an 343009, China.
Guo Q; Health Science Center, Jinggangshan University, Ji'an 343009, China.
Luo Y; Health Science Center, Jinggangshan University, Ji'an 343009, China.
Deng X; Health Science Center, Jinggangshan University, Ji'an 343009, China.
Huang Y; Center for Evidence Based Medical and Clinical Research, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Apr 12; Vol. 28 (8). Date of Electronic Publication: 2023 Apr 12.
Typ publikacji:: Journal Article
MeSH Terms:: Histamine H3 Antagonists*/chemistry
Receptors, Histamine H3*/metabolism
Rats ; Animals ; Humans ; Histamine ; Rats, Wistar ; Molecular Docking Simulation ; Dose-Response Relationship, Drug ; Anticonvulsants/chemistry ; Seizures/chemically induced ; Seizures/drug therapy ; Pentylenetetrazole/adverse effects

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Skocz do pozycji: 10.

Tytuł:: Histamine H1- and H2-receptors participate to provide metabolic energy differently.
Autorzy:: Mohammadi-Pilehdarboni H; Immunogenetic Research Center, Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.
Rasouli M; Immunogenetic Research Center, Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran.; Pokaż więcej
Źródło:: Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2022 Dec; Vol. 36 (6), pp. 1031-1037. Date of Electronic Publication: 2022 Jul 11.
Typ publikacji:: Journal Article
MeSH Terms:: Receptors, Histamine H2*/metabolism
Histamine*/pharmacology
Male ; Rats ; Animals ; Liver Glycogen ; Receptors, Histamine H1/physiology ; Histamine H2 Antagonists/pharmacology ; Glycogen ; Glucose

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Skocz do pozycji: 11.

Tytuł:: Hypolipemic effects of histamine is due to inhibition of VLDL secretion from the liver: involvement of both H1 and H2-receptors.
Autorzy:: Nikfar A; Faculty of Medicine, Department of Clinical Biochemistry and Immunogenetic Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Rasouli M; Faculty of Medicine, Department of Clinical Biochemistry and Immunogenetic Research Center, Mazandaran University of Medical Sciences, Sari, Iran.; Pokaż więcej
Źródło:: Archives of physiology and biochemistry [Arch Physiol Biochem] 2022 Dec; Vol. 128 (6), pp. 1566-1570. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji:: Journal Article
MeSH Terms:: Receptors, Histamine H2*/physiology
Histamine*/pharmacology
Male ; Rats ; Animals ; Famotidine/pharmacology ; Receptors, Histamine H1/physiology ; Cetirizine ; Histamine Agonists/pharmacology ; Liver ; Triglycerides ; Cholesterol ; Lipids

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Skocz do pozycji: 12.

Tytuł:: Ergotamine Stimulates Human 5-HT 4 -Serotonin Receptors and Human H 2 -Histamine Receptors in the Heart.
Autorzy:: Jacob H; Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Braekow P; Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Schwarz R; Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Höhm C; Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Kirchhefer U; Institute for Pharmacology and Toxicology, Medical Faculty, Westfälische Wilhelms-Universität, 48149 Münster, Germany.
Hofmann B; Department of Cardiac Surgery, Mid-German Heart Center, University Hospital Halle, 06120 Halle (Saale), Germany.
Neumann J; Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Gergs U; Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 01; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 01.
Typ publikacji:: Journal Article
MeSH Terms:: Ergotamine*/pharmacology
Heart Atria*/drug effects
Heart Atria*/metabolism
Receptors, Serotonin, 5-HT4*/metabolism
Serotonin 5-HT4 Receptor Agonists*/pharmacology
Receptors, Histamine H4*/agonists
Animals ; Humans ; Mice ; Myocardial Contraction/drug effects ; Receptors, Histamine/metabolism

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Skocz do pozycji: 13.

Tytuł:: An In Vivo Definition of Brain Histamine Dynamics Reveals Critical Neuromodulatory Roles for This Elusive Messenger.
Autorzy:: Berger SN; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA.
Baumberger B; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
Samaranayake S; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA.
Hersey M; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA.; Department of Physiology, Pharmacology & Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Mena S; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
Bain I; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA.
Duncan W; Department of Mathematics, Montana State University, Bozeman, MT 59717, USA.
Reed MC; Department of Mathematics, Duke University, Durham, NC 27710, USA.
Nijhout HF; Department of Biology, Duke University, Durham, NC 27708, USA.
Best J; Department of Mathematics, Ohio State University, Columbus, OH 43210, USA.
Hashemi P; Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA.; Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 28; Vol. 23 (23). Date of Electronic Publication: 2022 Nov 28.
Typ publikacji:: Journal Article
MeSH Terms:: Histamine*/metabolism
Receptors, Histamine H3*/metabolism
Female ; Animals ; Male ; Mice ; Serotonin/metabolism ; Histamine Agonists/pharmacology ; Histamine Agonists/metabolism ; Histamine Antagonists/pharmacology ; Histamine Antagonists/metabolism ; Brain/metabolism

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Skocz do pozycji: 14.

Tytuł:: The Histamine H 4 Receptor Participates in the Neuropathic Pain-Relieving Activity of the Histamine H 3 Receptor Antagonist GSK189254.
Autorzy:: Borgonetti V; Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy.
Galeotti N; Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Viale G. Pieraccini 6, 50139 Florence, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 18; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 18.
Typ publikacji:: Journal Article
MeSH Terms:: Histamine*
Neuralgia*/drug therapy
Animals ; Mice ; Receptors, Histamine ; Benzazepines/pharmacology ; Hyperalgesia/drug therapy ; Histamine Antagonists/pharmacology ; Histamine Antagonists/therapeutic use

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Skocz do pozycji: 15.

Tytuł:: Benzophenone Derivatives with Histamine H 3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease.
Autorzy:: Godyń J; Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Zaręba P; Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Stary D; Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, św. Łazarza 16 St., 31-530 Krakow, Poland.
Kaleta M; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Kuder KJ; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Latacz G; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Mogilski S; Department of Pharmacodynamics, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Reiner-Link D; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.
Frank A; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.
Doroz-Płonka A; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Olejarz-Maciej A; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Sudoł-Tałaj S; Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, św. Łazarza 16 St., 31-530 Krakow, Poland.; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Nolte T; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Handzlik J; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.
Więckowska A; Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Malawska B; Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Kieć-Kononowicz K; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Łażewska D; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.
Bajda M; Department of Physicochemical Drug Analysis, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, Poland.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2022 Dec 28; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 28.
Typ publikacji:: Journal Article
MeSH Terms:: Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Receptors, Histamine H3*/metabolism
Mice ; Animals ; Cholinesterases/metabolism ; Histamine ; Cholinesterase Inhibitors/pharmacology ; Receptors, Histamine ; Ligands ; Structure-Activity Relationship

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Skocz do pozycji: 16.

Tytuł:: Evaluation of the histamine H 3 receptor antagonists from LINS01 series as cholinesterases inhibitors: Enzymatic and modeling studies.
Autorzy:: Lopes FB; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo (Unifesp), Diadema, Brazil.
Aranha CMSQ; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo (Unifesp), Diadema, Brazil.
Corrêa MF; Department of Medicine, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil.
Fernandes GAB; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo (Unifesp), Diadema, Brazil.
Okamoto DN; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo (Unifesp), Diadema, Brazil.
Simões LPM; Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (Unesp), Araraquara, Brazil.
Junior NMN; Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (Unesp), Araraquara, Brazil.
Fernandes JPS; Department of Pharmaceutical Sciences, Universidade Federal de São Paulo (Unifesp), Diadema, Brazil.; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2022 Nov; Vol. 100 (5), pp. 722-729. Date of Electronic Publication: 2022 Sep 08.
Typ publikacji:: Letter; Research Support, Non-U.S. Gov't
MeSH Terms:: Alzheimer Disease*
Receptors, Histamine H3*/chemistry
Acetylcholine ; Acetylcholinesterase/metabolism ; Benzofurans/chemistry ; Benzofurans/pharmacology ; Butyrylcholinesterase/chemistry ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Histamine ; Histamine Antagonists/pharmacology ; Humans ; Ligands ; Molecular Docking Simulation ; Piperazines/chemistry ; Piperazines/pharmacology ; Structure-Activity Relationship ; Tryptophan

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Skocz do pozycji: 17.

Tytuł:: Drug Repurposing to Inhibit Histamine N -Methyl Transferase.
Autorzy:: Jiménez EM; Laboratorio de Cultivo Celular, Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Salvador Díaz Mirón Esq. Plan de San Luis s/n, Casco de Santo Tomas, Miguel Hidalgo, Mexico City 11340, Mexico.
Żołek T; Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-091 Warsaw, Poland.
Hernández Perez PG; Laboratorio de Cultivo Celular, Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Salvador Díaz Mirón Esq. Plan de San Luis s/n, Casco de Santo Tomas, Miguel Hidalgo, Mexico City 11340, Mexico.
Miranda Ruvalcaba R; Química Inorgánica-Orgánica del Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán Campo 1, UNAM. Av. Primero de Mayo S/N, Sta María Guadalupe las Torres, Cuautitlán Izcalli 54740, Mexico.
Nicolás-Vázquez MI; Química Inorgánica-Orgánica del Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán Campo 1, UNAM. Av. Primero de Mayo S/N, Sta María Guadalupe las Torres, Cuautitlán Izcalli 54740, Mexico.
Hernández-Rodríguez M; Laboratorio de Cultivo Celular, Sección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Salvador Díaz Mirón Esq. Plan de San Luis s/n, Casco de Santo Tomas, Miguel Hidalgo, Mexico City 11340, Mexico.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Jan 06; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 06.
Typ publikacji:: Journal Article
MeSH Terms:: Histamine*/metabolism
Transferases*
Histamine N-Methyltransferase/metabolism ; Vilazodone Hydrochloride ; Molecular Docking Simulation ; Drug Repositioning ; Dihydroergotamine

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Skocz do pozycji: 18.

Tytuł:: Histamine Activates Human Eosinophils via H 2 R and H 4 R Predominantly in Atopic Dermatitis Patients.
Autorzy:: Beyer L; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Kabatas AS; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Mommert S; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Universitätsstraße 1, 40225 Duesseldorf, Germany.
Werfel T; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Gutzmer R; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.; Department of Dermatology, Johannes Wesling Medical Center, Ruhr University Bochum Campus Minden, 32429 Minden, Germany.
Schaper-Gerhardt K; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.; Department of Dermatology, Johannes Wesling Medical Center, Ruhr University Bochum Campus Minden, 32429 Minden, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 07; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 07.
Typ publikacji:: Journal Article
MeSH Terms:: Dermatitis, Atopic*/metabolism
Histamine*/metabolism
Histamine*/pharmacology
Eosinophils/metabolism ; Humans ; Interleukin-18/genetics ; Interleukin-5 ; RNA, Messenger/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Histamine/genetics ; Receptors, Histamine/metabolism ; Receptors, Histamine H4 ; Receptors, Interleukin-18

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Skocz do pozycji: 19.

Tytuł:: Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N -Methyltransferase (HNMT) on Visceral Hypersensitivity.
Autorzy:: McClain JL; Department of Physiology, Michigan State University, 567 Wilson Road, East Lansing, MI 48824, USA.
Morales-Soto W; Department of Physiology, Michigan State University, 567 Wilson Road, East Lansing, MI 48824, USA.
Gonzales J; Department of Physiology, Michigan State University, 567 Wilson Road, East Lansing, MI 48824, USA.
Parmar V; Department of Physiology, Michigan State University, 567 Wilson Road, East Lansing, MI 48824, USA.
Demireva EY; Transgenic and Genome Editing Facility, Institute for Quantitative Health and Engineering, Michigan State University, 567 Wilson Road, East Lansing, MI 48824, USA.
Gulbransen BD; Department of Physiology, Michigan State University, 567 Wilson Road, East Lansing, MI 48824, USA.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2023 Nov 14; Vol. 13 (11). Date of Electronic Publication: 2023 Nov 14.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:: Histamine*/metabolism
Histamine N-Methyltransferase*/genetics
Female ; Male ; Mice ; Animals ; Neuroglia/metabolism ; Neurons/metabolism ; Brain/metabolism

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Skocz do pozycji: 20.

Tytuł:: The impact of skin color and tone on histamine iontophoresis and Doppler flowmetry measurements as a pharmacodynamic biomarker.
Autorzy:: Ramprasad A; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Ezekwe A; Division of Pediatric Clinical Pharmacology and Therapeutic Innovation and Section of Allergy/Asthma/Immunology, Children's Mercy Hospital, Kansas City, Missouri, USA.
Lee BR; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.; Division of Health Services and Outcomes Research, Children's Mercy Hospital, Kansas City, Missouri, USA.
Balasubramanian S; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Jones BL; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.; Division of Pediatric Clinical Pharmacology and Therapeutic Innovation and Section of Allergy/Asthma/Immunology, Children's Mercy Hospital, Kansas City, Missouri, USA.; Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.; Pokaż więcej
Źródło:: Clinical and translational science [Clin Transl Sci] 2024 Mar; Vol. 17 (3), pp. e13777.
Typ publikacji:: Observational Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Histamine*/pharmacology
Asthma*
Adult ; Child ; Humans ; Iontophoresis ; Skin Pigmentation ; Skin/diagnostic imaging ; Laser-Doppler Flowmetry/methods ; Biomarkers

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