Temat: "Histone Deacetylase 1" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Ellagic Acid Alleviates Rheumatoid Arthritis in Rats through Inhibiting MTA1/HDAC1-Mediated Nur77 Deacetylation.
Autorzy:: Song H; Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Wu H; Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Dong J; Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Huang S; Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Ye J; Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Liu R; Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.; Pokaż więcej
Źródło:: Mediators of inflammation [Mediators Inflamm] 2021 Dec 09; Vol. 2021, pp. 6359652. Date of Electronic Publication: 2021 Dec 09 (Print Publication: 2021).
Typ publikacji:: Journal Article
MeSH Terms:: Arthritis, Rheumatoid/*drug therapy
Ellagic Acid/*pharmacology
Histone Deacetylase 1/*antagonists & inhibitors
Repressor Proteins/*antagonists & inhibitors
Trans-Activators/*antagonists & inhibitors
Acetylation ; Animals ; Apoptosis/drug effects ; Cells, Cultured ; Histone Deacetylase 1/physiology ; Humans ; Male ; Nuclear Receptor Subfamily 4, Group A, Member 1/physiology ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Repressor Proteins/physiology ; Trans-Activators/physiology

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 2.

Tytuł:: Hydroxamic acid derivatives as HDAC1, HDAC6 and HDAC8 inhibitors with antiproliferative activity in cancer cell lines.
Autorzy:: Sixto-López Y; Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica (Laboratory for the Design and Development of New Drugs and Biotechnological Innovation)-SEPI, Escuela Superior de Medicina, Instituto Politécnico Nacional, 11340, Mexico City, Mexico.
Gómez-Vidal JA; Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, Universidad de Granada, 18071, Granada, Spain.
de Pedro N; Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, 18016, Granada, Spain.
Bello M; Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica (Laboratory for the Design and Development of New Drugs and Biotechnological Innovation)-SEPI, Escuela Superior de Medicina, Instituto Politécnico Nacional, 11340, Mexico City, Mexico.
Rosales-Hernández MC; Laboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, Mexico.
Correa-Basurto J; Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica (Laboratory for the Design and Development of New Drugs and Biotechnological Innovation)-SEPI, Escuela Superior de Medicina, Instituto Politécnico Nacional, 11340, Mexico City, Mexico. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jun 26; Vol. 10 (1), pp. 10462. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Cell Proliferation/*drug effects
Histone Deacetylase 1/*metabolism
Histone Deacetylase 6/*metabolism
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Hydroxamic Acids/*pharmacology
Repressor Proteins/*metabolism
Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Drug Design ; Drug Screening Assays, Antitumor/methods ; Female ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; MCF-7 Cells ; Molecular Docking Simulation

Czasopismo naukowe

na półce

Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 3.

Tytuł:: ING2, a tumor associated gene, enhances PAI‑1 and HSPA1A expression with HDAC1 and mSin3A through the PHD domain and C‑terminal.
Autorzy:: Ohkouchi C; Department of Thyroid and Endocrinology, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan.
Kumamoto K; Department of Coloproctology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Fukushima 969‑3492, Japan.
Saito M; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ishigame T; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Suzuki SI; Department of Thyroid and Endocrinology, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan.
Takenoshita S; Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan.
Harris CC; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2017 Nov; Vol. 16 (5), pp. 7367-7374. Date of Electronic Publication: 2017 Sep 20.
Typ publikacji:: Journal Article
MeSH Terms:: HSP70 Heat-Shock Proteins/*metabolism
Histone Deacetylase 1/*metabolism
Homeodomain Proteins/*metabolism
Plasminogen Activator Inhibitor 1/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
Repressor Proteins/*metabolism
Tumor Suppressor Proteins/*metabolism
HEK293 Cells ; HSP70 Heat-Shock Proteins/genetics ; Histone Deacetylase 1/genetics ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Homeodomain Proteins/chemistry ; Homeodomain Proteins/genetics ; Humans ; Inhibitor of Growth Protein 1/chemistry ; Inhibitor of Growth Protein 1/genetics ; Inhibitor of Growth Protein 1/metabolism ; Matrix Metalloproteinase 13/genetics ; Matrix Metalloproteinase 13/metabolism ; Matrix Metalloproteinase 2/metabolism ; PHD Zinc Fingers ; Plasmids/genetics ; Plasmids/metabolism ; Plasminogen Activator Inhibitor 1/genetics ; Point Mutation ; Protein Array Analysis ; Receptors, Cytoplasmic and Nuclear/chemistry ; Receptors, Cytoplasmic and Nuclear/genetics ; Repressor Proteins/genetics ; Sin3 Histone Deacetylase and Corepressor Complex ; Tumor Suppressor Proteins/chemistry ; Tumor Suppressor Proteins/genetics ; Up-Regulation

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 4.

Tytuł:: The Novel HDAC8 Inhibitor WK2-16 Attenuates Lipopolysaccharide-Activated Matrix Metalloproteinase-9 Expression in Human Monocytic Cells and Improves Hypercytokinemia In Vivo.
Autorzy:: Jan JS; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. .; Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. .
Chou YC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. .; Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. .
Cheng YW; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan. .
Chen CK; Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. .; School of Medicine, Chang Gung University, Taoyuan 333, Taiwan. .; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. .
Huang WJ; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan. .
Hsiao G; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. .; Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. .; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan. .; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2017 Jun 29; Vol. 18 (7). Date of Electronic Publication: 2017 Jun 29.
Typ publikacji:: Journal Article
MeSH Terms:: Cytokines/*drug effects
Cytokines/*metabolism
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*drug effects
Histone Deacetylases/*metabolism
Lipopolysaccharides/*pharmacology
Matrix Metalloproteinase 9/*drug effects
Matrix Metalloproteinase 9/*metabolism
Repressor Proteins/*drug effects
Repressor Proteins/*metabolism
Acetylation ; Animals ; Cell Cycle Proteins/metabolism ; Cell Survival/drug effects ; Chondroitin Sulfate Proteoglycans/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Cyclooxygenase 2/drug effects ; Down-Regulation ; Endotoxemia ; Histone Deacetylase 1/drug effects ; Humans ; Interleukin-6 ; JNK Mitogen-Activated Protein Kinases/drug effects ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Monocytes/metabolism ; NF-kappa B/metabolism ; RNA, Messenger/biosynthesis ; RNA, Messenger/drug effects ; Sepsis/drug therapy ; Signal Transduction/drug effects ; THP-1 Cells/drug effects ; Tubulin/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/pharmacology ; YY1 Transcription Factor/metabolism ; p38 Mitogen-Activated Protein Kinases/drug effects

Czasopismo naukowe

na półce

Pełny tekst Szczegóły

Skocz do pozycji: 5.

Tytuł:: Involvement of the NFX1-repressor complex in PKC-δ-induced repression of hTERT transcription.
Autorzy:: Yamashita S; Graduate School of Systems Life Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Fujii K; Graduate School of Systems Life Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Zhao C; Graduate School of Systems Life Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Takagi H; Graduate School of Systems Life Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Katakura Y; Graduate School of Systems Life Sciences, Kyushu University, Fukuoka 812-8581, Japan .; Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.; Pokaż więcej
Źródło:: Journal of biochemistry [J Biochem] 2016 Nov; Vol. 160 (5), pp. 309-313. Date of Electronic Publication: 2016 Jun 15.
Typ publikacji:: Journal Article
MeSH Terms:: Cellular Senescence*
Multiprotein Complexes/*metabolism
Protein Kinase C-delta/*metabolism
Repressor Proteins/*metabolism
Telomerase/*biosynthesis
Transcription, Genetic/*physiology
Cell Line, Tumor ; Histone Deacetylase 1/genetics ; Histone Deacetylase 1/metabolism ; Humans ; Multiprotein Complexes/genetics ; Protein Kinase C-delta/genetics ; Repressor Proteins/genetics ; Sin3 Histone Deacetylase and Corepressor Complex ; Telomerase/genetics