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Wyszukujesz frazę ""Histone Deacetylase Inhibitors"" wg kryterium: Temat


Tytuł:
Nanoencapsulation of MDM2 Inhibitor RG7388 and Class-I HDAC Inhibitor Entinostat Enhances their Therapeutic Potential Through Synergistic Antitumor Effects and Reduction of Systemic Toxicity.
Autorzy:
Abed A; The Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.; Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19111, Jordan.
Greene MK; The Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.
Alsa'd AA; Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19111, Jordan.; School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom.
Lees A; The Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.
Hindley A; Clinical Haematology, Belfast City Hospital, 97 Lisburn Road, Belfast, BT9 7AB, United Kingdom.
Longley DB; The Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.
McDade SS; The Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.
Scott CJ; The Patrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, United Kingdom.
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Źródło:
Molecular pharmaceutics [Mol Pharm] 2024 Mar 04; Vol. 21 (3), pp. 1246-1255. Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Benzamides*
Pyridines*
Pyrrolidines*
para-Aminobenzoates*
Humans ; Animals ; Mice ; Tumor Suppressor Protein p53/metabolism ; Apoptosis ; Cell Line, Tumor ; Drug Combinations ; Proto-Oncogene Proteins c-mdm2
Czasopismo naukowe
Tytuł:
Overcoming doxorubicin resistance in triple-negative breast cancer using the class I-targeting HDAC inhibitor bocodepsin/OKI-179 to promote apoptosis.
Autorzy:
Smoots SG; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA.
Schreiber AR; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA.
Jackson MM; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA.
Bagby SM; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA.
Dominguez ATA; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA.
Dus ED; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA.
Binns CA; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA.
MacBeth M; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA.
Whitty PA; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA.
Diamond JR; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA.
Pitts TM; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue MS8117, Aurora, CO, 80045, USA. .
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Źródło:
Breast cancer research : BCR [Breast Cancer Res] 2024 Mar 01; Vol. 26 (1), pp. 35. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/genetics
Triple Negative Breast Neoplasms*/metabolism
Humans ; Tumor Suppressor Protein p53/genetics ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Apoptosis ; RNA, Small Interfering
Czasopismo naukowe
Tytuł:
HDAC/NAMPT dual inhibitors overcome initial drug-resistance in p53-null leukemia cells.
Autorzy:
Yue K; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China.
Sun S; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China.
Liu E; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China.
Liu J; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China.
Hou B; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China.
Qi K; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China.
Chou CJ; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC, 29425, United States; Neuroene Therapeutics, JLABS at the Children's National Research and Innovation Campus, 7144 13th PL NW, Washington, DC, 20012-2358, United States. Electronic address: .
Jiang Y; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266003, China; Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao, Shandong, 266003, China. Electronic address: .
Li X; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266003, China; Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao, Shandong, 266003, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2024 Feb 15; Vol. 266, pp. 116127. Date of Electronic Publication: 2024 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/chemistry
Leukemia*/drug therapy
Leukemia*/metabolism
Humans ; Tumor Suppressor Protein p53 ; Nicotinamide Phosphoribosyltransferase/metabolism ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor.
Autorzy:
Sprinzen L; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Garcia F; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Mela A; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Lei L; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Upadhyayula P; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Mahajan A; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Humala N; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
Manier L; Department of Chemistry, Vanderbilt School of Medicine, Nashville, TN 37240, USA.
Caprioli R; Department of Chemistry, Vanderbilt School of Medicine, Nashville, TN 37240, USA.
Quiñones-Hinojosa A; Department of Neurosurgery, Mayo Clinic, Jacksonville, FL 32224, USA.
Casaccia P; Neuroscience Initiative, Advanced Science Research Center, City University of New York, New York, NY 10031, USA.
Canoll P; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
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Źródło:
Cells [Cells] 2024 Jan 25; Vol. 13 (3). Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Glioma*/drug therapy
Glioma*/genetics
Glioma*/pathology
Biphenyl Compounds*
Morpholines*
Pyridones*
Animals ; Mice ; Histones/genetics ; Benzamides
Czasopismo naukowe
Tytuł:
Serendipitous discovery of Class I HDAC inhibitors from rational design of molecular glue degraders targeting HDAC.
Autorzy:
Chen D; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China.
Lin S; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China; Department of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, 550002, China.
Zeng Z; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China.
An J; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China.
Yan W; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China.
Gu Z; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China.
Chen L; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China.
He B; State Key Laboratory of Functions and Applications of Medicinal Plants, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang, 550004, China. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2024 Jan 05; Vol. 263, pp. 115926. Date of Electronic Publication: 2023 Nov 19.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Neoplasms*/drug therapy
Humans ; Thalidomide/pharmacology ; Thalidomide/therapeutic use
Czasopismo naukowe
Tytuł:
Successful reversal of transgene silencing in Chlamydomonas reinhardtii.
Autorzy:
Beauchemin R; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.
Merindol N; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.
Fantino E; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.
Lavoie P; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.
Nouemssi SB; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.
Meddeb-Mouelhi F; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.
Desgagné-Penix I; Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.; Plant Biology Research Group, Trois-Rivières, Québec, Canada.
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Źródło:
Biotechnology journal [Biotechnol J] 2024 Jan; Vol. 19 (1), pp. e2300232. Date of Electronic Publication: 2023 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/chemistry
Chlamydomonas reinhardtii*/genetics
Chlamydomonas reinhardtii*/metabolism
Vorinostat ; Hydroxamic Acids/pharmacology ; Hydroxamic Acids/chemistry ; Histone Deacetylases/metabolism ; Transgenes/genetics
Czasopismo naukowe
Tytuł:
Evaluation and molecular docking study of two flavonoids from Oroxylum indicum (L.) Kurz and their semi-synthetic derivatives as histone deacetylase inhibitors.
Autorzy:
Somsakeesit LO; Natural Products Research Unit, Department of Chemistry, Faculty of Science, Center of Excellence for Innovation in Chemistry, Ministry of Higher Education, Science, Research, and Innovation (Implementation Unit-IU, Khon Kaen University), Khon Kaen University, Khon Kaen, 40002, Thailand.
Senawong T; Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
Senawong G; Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
Kumboonma P; Department of Applied Chemistry, Faculty of Science and Liberal Arts, Rajamangala University of Technology Isan, Nakhon Ratchasima, 30000, Thailand.
Samankul A; Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
Namwan N; Natural Products Research Unit, Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
Yenjai C; Natural Products Research Unit, Department of Chemistry, Faculty of Science, Center of Excellence for Innovation in Chemistry, Ministry of Higher Education, Science, Research, and Innovation (Implementation Unit-IU, Khon Kaen University), Khon Kaen University, Khon Kaen, 40002, Thailand.
Phaosiri C; Natural Products Research Unit, Department of Chemistry, Faculty of Science, Center of Excellence for Innovation in Chemistry, Ministry of Higher Education, Science, Research, and Innovation (Implementation Unit-IU, Khon Kaen University), Khon Kaen University, Khon Kaen, 40002, Thailand. .
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Źródło:
Journal of natural medicines [J Nat Med] 2024 Jan; Vol. 78 (1), pp. 236-245. Date of Electronic Publication: 2023 Nov 22.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/chemistry
Antineoplastic Agents*/pharmacology
Humans ; HeLa Cells ; Molecular Docking Simulation ; Histone Deacetylases/metabolism ; Histone Deacetylases/pharmacology ; Flavonoids/pharmacology ; Structure-Activity Relationship ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Repressor Proteins/metabolism ; Repressor Proteins/pharmacology
Czasopismo naukowe
Tytuł:
Genome-wide CRISPR/Cas9 knockout screening to mitigate cell growth inhibition induced by histone deacetylase inhibitors in recombinant CHO cells.
Autorzy:
Kim D; Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.
Kim SH; Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.
Yoon C; Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.
Lee GM; Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.
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Źródło:
Biotechnology and bioengineering [Biotechnol Bioeng] 2024 Mar; Vol. 121 (3), pp. 931-941. Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article
MeSH Terms:
CRISPR-Cas Systems*
Histone Deacetylase Inhibitors*/pharmacology
Cricetinae ; Animals ; Cricetulus ; CHO Cells ; Cell Proliferation
Czasopismo naukowe
Tytuł:
Discovery of Novel Metalloenzyme Inhibitors Based on Property Characterization: Strategy and Application for HDAC1 Inhibitors.
Autorzy:
Zhang L; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; Department of Toxicology, Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
Yang Y; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yang Y; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Xiao Z; Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.; State Key Laboratory of Digestive Health, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 29; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Metalloproteins*/chemistry
Humans ; Drug Discovery ; Zinc ; Histone Deacetylase 1
Czasopismo naukowe
Tytuł:
Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a.
Autorzy:
Armani-Tourret M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Gao C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Hartana CA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sun W; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Carrere L; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Vela L; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Hochroth A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Bellefroid M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Sbrolla A; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
Shea K; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
Flynn T; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
Roseto I; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Rassadkina Y; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Lee C; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Giguel F; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Malhotra R; Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Bushman FD; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gandhi RT; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
Yu XG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Kuritzkes DR; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Lichterfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło:
Cell [Cell] 2024 Feb 29; Vol. 187 (5), pp. 1238-1254.e14. Date of Electronic Publication: 2024 Feb 17.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
HIV Infections*/drug therapy
HIV-1*/genetics
Panobinostat*/therapeutic use
Proviruses*/drug effects
Histone Deacetylase Inhibitors*/therapeutic use
Interferon-alpha*/therapeutic use
Humans ; Virus Latency
Czasopismo naukowe
Tytuł:
Multitargeting HDAC Inhibitors Containing a RAS/RAF Protein Interfering Unit.
Autorzy:
Wang Y; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, PR China.
Zhang J; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
Li K; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
Xia S; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
Gou S; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, PR China.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2024 Feb 08; Vol. 67 (3), pp. 2066-2082. Date of Electronic Publication: 2024 Jan 23.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Antineoplastic Agents*/pharmacology
Sulfones*
Glycine/*analogs & derivatives
Humans ; Animals ; Mice ; Hydroxamic Acids/pharmacology ; Hydroxamic Acids/chemistry ; Cell Line, Tumor ; Cell Proliferation ; Vorinostat/pharmacology ; Apoptosis
Czasopismo naukowe
Tytuł:
The impact of selective HDAC inhibitors on the transcriptome of early mouse embryos.
Autorzy:
Shao R; Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan.
Suzuki T; SANKEN, Osaka University, 8-1 Mihogaoka, 567-0047, Ibaraki, Osaka, Japan.
Suyama M; Division of Bioinformatics, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan. .
Tsukada Y; Advanced Biological Information Research Division, INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, 819-0395, Fukuoka, Japan. .
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Źródło:
BMC genomics [BMC Genomics] 2024 Feb 05; Vol. 25 (1), pp. 143. Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Transcriptome*
Pregnancy ; Female ; Mice ; Animals ; Benzamides/pharmacology ; Pyrimidines/pharmacology
Czasopismo naukowe
Tytuł:
CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma.
Autorzy:
Li Y; Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China.; Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders/ Xiangya Hospital, Central South University, Changsha, 410078, China.; Key Laboratory of Carcinogenesis of National Health Commission, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, 410078, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yang C; Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China.; Key Laboratory of Carcinogenesis of National Health Commission, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, 410078, China.
Xie L; Children's Hospital, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410008, China.
Shi F; Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China.; Key Laboratory of Carcinogenesis of National Health Commission, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, 410078, China.
Tang M; Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China.; Key Laboratory of Carcinogenesis of National Health Commission, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, 410078, China.; Molecular Imaging Research Center of Central South University, Changsha, 410008, Hunan, China.
Luo X; Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China.; Key Laboratory of Carcinogenesis of National Health Commission, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, 410078, China.; Molecular Imaging Research Center of Central South University, Changsha, 410008, Hunan, China.
Liu N; Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China.; Key Laboratory of Carcinogenesis of National Health Commission, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, 410078, China.
Hu X; Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China.; Key Laboratory of Carcinogenesis of National Health Commission, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, 410078, China.
Zhu Y; Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders/ Xiangya Hospital, Central South University, Changsha, 410078, China.; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Bode AM; The Hormel Institute, University of Minnesota, Austin, MN, 55912, USA.
Gao Q; Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Zhongshan Hospital, Shanghai Medical School, Fudan University, Shanghai, 200000, China.
Zhou J; Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Zhongshan Hospital, Shanghai Medical School, Fudan University, Shanghai, 200000, China.
Fan J; Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Zhongshan Hospital, Shanghai Medical School, Fudan University, Shanghai, 200000, China.
Li X; Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China. .; Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders/ Xiangya Hospital, Central South University, Changsha, 410078, China. .; Hunan International Scientific and Technological Cooperation Base of Brain Tumor Research, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. .
Cao Y; Key Laboratory of Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410078, China. .; Key Laboratory of Carcinogenesis of National Health Commission, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, 410078, China. .; Molecular Imaging Research Center of Central South University, Changsha, 410008, Hunan, China. .; Department of Radiology, National Clinical Research Center for Geriatric Disorders/ Xiangya Hospital, Central South University, Changsha, 410078, China. .; Research Center for Technologies of Nucleic Acid-Based Diagnostics and Therapeutics Hunan Province, Changsha, 410078, China. .; National Joint Engineering Research Center for Genetic Diagnostics of Infectious Diseases and Cancer, Changsha, 410078, China. .
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Źródło:
Cell death & disease [Cell Death Dis] 2024 Jan 29; Vol. 15 (1), pp. 95. Date of Electronic Publication: 2024 Jan 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Nasopharyngeal Neoplasms*/genetics
Nasopharyngeal Neoplasms*/radiotherapy
Humans ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Carcinoma/radiotherapy ; Oxidative Stress ; Histone Deacetylases/metabolism ; Deubiquitinating Enzyme CYLD/genetics ; Deubiquitinating Enzyme CYLD/metabolism ; Repressor Proteins/metabolism
Czasopismo naukowe
Tytuł:
EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer.
Autorzy:
Joseph R; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Dasari SK; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Umamaheswaran S; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mangala LS; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Bayraktar E; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rodriguez-Aguayo C; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Wu Y; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Nguyen N; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Powell RT; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Sobieski M; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Liu Y; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Kim MS; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Corvigno S; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Foster K; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hanjra P; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Vu TC; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Chowdhury MA; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Amero P; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Stephan C; High-Throughput Research and Screening Center, Center for Translational Cancer Research, Texas A&M Health Science Center, Institute of Biosciences and Technology, Houston, TX 77030, USA.
Lopez-Berestein G; Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Westin SN; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sood AK; Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 20; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Endometrial Neoplasms*/drug therapy
Endometrial Neoplasms*/genetics
Endometrial Neoplasms*/pathology
Histone Deacetylase Inhibitors*/therapeutic use
Receptor, EphA2*/antagonists & inhibitors
Animals ; Female ; Humans ; Mice ; Apoptosis ; Cell Line, Tumor ; Panobinostat/pharmacology ; Panobinostat/therapeutic use ; Phosphatidylinositol 3-Kinases ; Molecular Targeted Therapy
Czasopismo naukowe
Tytuł:
Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors.
Autorzy:
Keeley AB; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Müegyetem rkp. 3., H-1111 Budapest, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
Kopranovic A; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Haardtring 100, 64295 Darmstadt, Germany.
Di Lorenzo V; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Müegyetem rkp. 3., H-1111 Budapest, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
Ábrányi-Balogh P; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Müegyetem rkp. 3., H-1111 Budapest, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
Jänsch N; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Haardtring 100, 64295 Darmstadt, Germany.
Lai LN; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Haardtring 100, 64295 Darmstadt, Germany.
Petri L; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Müegyetem rkp. 3., H-1111 Budapest, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
Orgován Z; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Müegyetem rkp. 3., H-1111 Budapest, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
Pölöske D; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.
Orlova A; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.
Németh AG; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Müegyetem rkp. 3., H-1111 Budapest, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
Desczyk C; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Haardtring 100, 64295 Darmstadt, Germany.
Imre T; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.; MS Metabolomics Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.
Bajusz D; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Müegyetem rkp. 3., H-1111 Budapest, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria.
Meyer-Almes FJ; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Haardtring 100, 64295 Darmstadt, Germany.
Keserü GM; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Müegyetem rkp. 3., H-1111 Budapest, Hungary.; National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2024 Jan 11; Vol. 67 (1), pp. 572-585. Date of Electronic Publication: 2023 Dec 19.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/chemistry
Histone Deacetylases*/metabolism
Humans ; Binding Sites ; Tandem Mass Spectrometry ; Ligands ; Repressor Proteins/metabolism
Czasopismo naukowe
Tytuł:
5-(Trifluoromethyl)-1,2,4-oxadiazole (TFMO)-based highly selective class IIa HDAC inhibitors exhibit synergistic anticancer activity in combination with bortezomib.
Autorzy:
Asfaha Y; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.
Bollmann LM; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.
Skerhut AJ; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.
Fischer F; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.
Horstick N; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.
Roth D; Department of Surgery (A), Medical Faculty, University Hospital of the Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Wecker M; Department of Surgery (A), Medical Faculty, University Hospital of the Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Mammen C; Institute of Biochemistry I, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.
Smits SHJ; Institute of Biochemistry I, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany; Center for Structural Studies, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.
Fluegen G; Department of Surgery (A), Medical Faculty, University Hospital of the Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Kassack MU; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.
Kurz T; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany. Electronic address: .
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Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2024 Jan 05; Vol. 263, pp. 115907. Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Antineoplastic Agents*/pharmacology
Bortezomib/pharmacology ; Oxadiazoles/pharmacology ; Hydroxamic Acids/pharmacology
Czasopismo naukowe
Tytuł:
Discussion on structure classification and regulation function of histone deacetylase and their inhibitor.
Autorzy:
Han H; Department of Biochemistry and Molecular Biology, Shenyang Medical College, Shenyang City, P. R. China.
Feng X; Department of Pathogen Biology, Shenyang Medical College, Shenyang City, P. R. China.
He T; Department of Pathogen Biology, Shenyang Medical College, Shenyang City, P. R. China.
Wu Y; Department of Pathogen Biology, Shenyang Medical College, Shenyang City, P. R. China.
He T; Department of Pathogen Biology, Shenyang Medical College, Shenyang City, P. R. China.
Yue Z; Department of Pathogen Biology, Shenyang Medical College, Shenyang City, P. R. China.
Zhou W; Department of Pathogen Biology, Shenyang Medical College, Shenyang City, P. R. China.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2024 Jan; Vol. 103 (1), pp. e14366. Date of Electronic Publication: 2023 Sep 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Histone Deacetylase Inhibitors*/chemistry
Neoplasms*/drug therapy
Neoplasms*/pathology
Humans ; Histone Deacetylases/metabolism ; Epigenesis, Genetic ; Histones/metabolism
Czasopismo naukowe
Tytuł:
Effects of histone acetyltransferase (HAT) and histone deacetylase (HDAC) inhibitors on proliferative, differentiative, and regenerative functions of Toll-like receptor 2 (TLR-2)-stimulated human dental pulp cells (hDPCs).
Autorzy:
Fahmy SH; Department of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt. .; Department of Periodontology, Operative and Preventive Dentistry, Center of Dento-Maxillo-Facial Medicine, Faculty of Medicine, University of Bonn, University Hospital of Bonn, Bonn, Germany. .
Jungbluth H; Department of Periodontology, Operative and Preventive Dentistry, Center of Dento-Maxillo-Facial Medicine, Faculty of Medicine, University of Bonn, University Hospital of Bonn, Bonn, Germany.
Jepsen S; Department of Periodontology, Operative and Preventive Dentistry, Center of Dento-Maxillo-Facial Medicine, Faculty of Medicine, University of Bonn, University Hospital of Bonn, Bonn, Germany.
Winter J; Department of Periodontology, Operative and Preventive Dentistry, Center of Dento-Maxillo-Facial Medicine, Faculty of Medicine, University of Bonn, University Hospital of Bonn, Bonn, Germany.
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Źródło:
Clinical oral investigations [Clin Oral Investig] 2023 Dec 29; Vol. 28 (1), pp. 53. Date of Electronic Publication: 2023 Dec 29.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/metabolism
Toll-Like Receptor 2*/metabolism
Humans ; Dental Pulp ; Histone Acetyltransferases/metabolism ; Histone Acetyltransferases/pharmacology ; Valproic Acid/metabolism ; Valproic Acid/pharmacology ; Histone Deacetylases/metabolism ; Histone Deacetylases/pharmacology ; Defensins/metabolism ; Defensins/pharmacology
Czasopismo naukowe
Tytuł:
Intra-articular Histone Deacetylase Inhibitor Microcarrier Delivery to Reduce Osteoarthritis.
Autorzy:
Ye J; Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China.; Institute of Sports Medicine, Peking University, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Deng R; Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China.; Institute of Sports Medicine, Peking University, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Wang X; Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China.; Institute of Sports Medicine, Peking University, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Song S; Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China.; Institute of Sports Medicine, Peking University, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Xu X; Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Zhang JY; Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China.; Institute of Sports Medicine, Peking University, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Xu BB; Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China.; Institute of Sports Medicine, Peking University, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Wang X; Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Yu JK; Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China.; Institute of Sports Medicine, Peking University, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
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Źródło:
Nano letters [Nano Lett] 2023 Dec 13; Vol. 23 (23), pp. 10832-10840. Date of Electronic Publication: 2023 Nov 27.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Osteoarthritis*/drug therapy
Humans ; Delayed-Action Preparations/therapeutic use ; Capsules
Czasopismo naukowe
Tytuł:
In the quest for histone deacetylase inhibitors: current trends in the application of multilayered computational methods.
Autorzy:
Uba AI; Department of Molecular Biology and Genetics, Istanbul AREL University, Istanbul, 34537, Turkey. .
Zengin G; Department of Biology, Science Faculty, Selcuk University, Konya, 42130, Turkey. .
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Źródło:
Amino acids [Amino Acids] 2023 Dec; Vol. 55 (12), pp. 1709-1726. Date of Electronic Publication: 2023 Jun 27.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Histone Deacetylase Inhibitors*/pharmacology
Histone Deacetylase Inhibitors*/therapeutic use
Molecular Dynamics Simulation*
Molecular Docking Simulation ; Ligands ; Quantitative Structure-Activity Relationship
Czasopismo naukowe

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