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Wyszukujesz frazę ""Histone Deacetylase Inhibitors"" wg kryterium: Temat


Tytuł :
Hybrid inhibitors of DNA and HDACs remarkably enhance cytotoxicity in leukaemia cells.
Autorzy :
Song Y; College of Pharmacy, Keimyung University, Daegu, Republic of Korea.
Park SY; College of Pharmacy, Keimyung University, Daegu, Republic of Korea.
Wu Z; BK21 Plus KNU Multi-Omics based Creative Drug Research Team, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea.
Liu KH; BK21 Plus KNU Multi-Omics based Creative Drug Research Team, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea.
Seo YH; College of Pharmacy, Keimyung University, Daegu, Republic of Korea.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1069-1079.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Chlorambucil/*pharmacology
DNA, Neoplasm/*drug effects
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Leukemia, Lymphocytic, Chronic, B-Cell/*drug therapy
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Chlorambucil/chemical synthesis ; Chlorambucil/chemistry ; DNA Damage ; DNA, Neoplasm/chemistry ; Dose-Response Relationship, Drug ; Drug Design ; Drug Screening Assays, Antitumor ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Molecular Structure ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer.
Autorzy :
Ruzzolini J; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Laurenzana A; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Andreucci E; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Peppicelli S; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Bianchini F; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Carta F; Department of NEUROFARBA, University of Florence, Florence, Italy.
Supuran CT; Department of NEUROFARBA, University of Florence, Florence, Italy.
Romanelli MN; Department of NEUROFARBA, University of Florence, Florence, Italy.
Nediani C; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Calorini L; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.; Center of Excellence for Research, Transfer and High Education, DenoTHE University of Florence, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 391-397.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Phenylurea Compounds/*pharmacology
Sulfonamides/*pharmacology
Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Molecular Structure ; Phenylurea Compounds/chemical synthesis ; Phenylurea Compounds/chemistry ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Autorzy :
Ho TCS; School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
Chan AHY; School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
Ganesan A; School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12460-12484. Date of Electronic Publication: 2020 Jul 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Histone Deacetylase Inhibitors/*chemistry
Histone Deacetylases/*metabolism
Anilides/chemistry ; Anilides/metabolism ; Anilides/therapeutic use ; Biological Products/chemistry ; Biological Products/metabolism ; Biological Products/therapeutic use ; Clinical Trials as Topic ; Histone Deacetylase Inhibitors/metabolism ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylases/chemistry ; Humans ; Hydroxamic Acids/chemistry ; Hydroxamic Acids/metabolism ; Hydroxamic Acids/therapeutic use ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Lymphoma/drug therapy ; Lymphoma/pathology ; Sulfhydryl Compounds/chemistry ; Sulfhydryl Compounds/metabolism ; Sulfhydryl Compounds/therapeutic use
Czasopismo naukowe
Tytuł :
Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab.
Autorzy :
García-Guerrero E; Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Götz R; Department of Biotechnology and Biophysics, Biocenter, and RVZ for Integrative and Translational BioImaging, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
Doose S; Department of Biotechnology and Biophysics, Biocenter, and RVZ for Integrative and Translational BioImaging, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
Sauer M; Department of Biotechnology and Biophysics, Biocenter, and RVZ for Integrative and Translational BioImaging, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
Rodríguez-Gil A; Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Nerreter T; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.
Kortüm KM; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.
Pérez-Simón JA; Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Einsele H; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.
Hudecek M; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.
Danhof S; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany. .
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Źródło :
Leukemia [Leukemia] 2021 Jan; Vol. 35 (1), pp. 201-214. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ADP-ribosyl Cyclase 1/*genetics
Antibodies, Monoclonal/*pharmacology
Antineoplastic Agents/*pharmacology
Gene Expression Regulation, Neoplastic/*drug effects
Histone Deacetylase 6/*antagonists & inhibitors
Histone Deacetylase Inhibitors/*pharmacology
Membrane Glycoproteins/*genetics
Multiple Myeloma/*genetics
ADP-ribosyl Cyclase 1/metabolism ; Antibody-Dependent Cell Cytotoxicity/drug effects ; Antibody-Dependent Cell Cytotoxicity/immunology ; Cell Line, Tumor ; Drug Synergism ; Histone Deacetylase Inhibitors/therapeutic use ; Humans ; Hydroxamic Acids/pharmacology ; Immunophenotyping ; Membrane Glycoproteins/metabolism ; Models, Biological ; Multiple Myeloma/drug therapy ; Multiple Myeloma/metabolism ; Pyrimidines/pharmacology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Tytuł :
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.
Autorzy :
Wang X; Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, PR China.
Liu K; Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, PR China.
Gong H; Department of Oral, Dalian Stomatological Hospital, Dalian, Liaoning 116021, PR China.
Li D; Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, PR China.
Chu W; Department of Pharmacology (The State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, PR China.
Zhao D; Department of Clinical Pharmacy (Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment), the 2nd Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, PR China.
Wang X; Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, PR China. Electronic address: .
Xu D; Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, PR China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Jan 01; Vol. 410, pp. 115363. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Ferroptosis/*drug effects
Histone Deacetylase Inhibitors/*therapeutic use
Hydroxamic Acids/*therapeutic use
Pyroptosis/*drug effects
Tongue Neoplasms/*drug therapy
Animals ; Apoptosis/physiology ; Cell Death/drug effects ; Cell Death/physiology ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Ferroptosis/physiology ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Hydroxamic Acids/pharmacology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Pyroptosis/physiology ; Tongue Neoplasms/metabolism ; Tongue Neoplasms/pathology ; Tumor Burden/drug effects ; Tumor Burden/physiology ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Dual inhibitors of histone deacetylases and other cancer-related targets: A pharmacological perspective.
Autorzy :
Gao Y; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, PR China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, PR China; Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, PR China; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China; School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510000, PR China.
Zhang H; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, PR China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, PR China; Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, PR China; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China; School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510000, PR China; Department of Basic Medicine, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China.
Lirussi F; INSERM, U1231, Label LipSTIC, and Ligue Nationale contre le Cancer, Dijon, France; Université de Bourgogne-Franche Comté, I-SITE, France; University Hospital of Dijon (CHU), France.
Garrido C; INSERM, U1231, Label LipSTIC, and Ligue Nationale contre le Cancer, Dijon, France; Université de Bourgogne-Franche Comté, I-SITE, France; Anti-cancer Center George-François Leclerc, CGFL, Dijon, France. Electronic address: .
Ye XY; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, PR China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, PR China; Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, PR China; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China. Electronic address: .
Xie T; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, PR China; Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, PR China; Collaborative Innovation Center of Chinese Medicines from Zhejiang Province, PR China; College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, PR China. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114224. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*metabolism
Drug Delivery Systems/*methods
Histone Deacetylase Inhibitors/*metabolism
Histone Deacetylases/*metabolism
Neoplasms/*drug therapy
Neoplasms/*metabolism
Animals ; Antineoplastic Agents/administration & dosage ; Histone Deacetylase Inhibitors/administration & dosage ; Humans
Czasopismo naukowe
Tytuł :
Histone deacetylase 3-selective inhibitor RGFP966 ameliorates impaired glucose tolerance through β-cell protection.
Autorzy :
Lei L; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Bai G; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wang X; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Liu S; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Xia J; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wu S; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Huan Y; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: .
Shen Z; The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Nov 01; Vol. 406, pp. 115189. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acrylamides/*therapeutic use
Diabetes Mellitus, Experimental/*drug therapy
Glucose Intolerance/*drug therapy
Histone Deacetylase Inhibitors/*therapeutic use
Histone Deacetylases/*metabolism
Hypoglycemic Agents/*therapeutic use
Phenylenediamines/*therapeutic use
Acrylamides/pharmacology ; Animals ; Cell Line ; Diabetes Mellitus, Experimental/genetics ; Diabetes Mellitus, Experimental/metabolism ; Gene Expression/drug effects ; Histone Deacetylase Inhibitors/pharmacology ; Hypoglycemic Agents/pharmacology ; Insulin Secretion/drug effects ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Phenylenediamines/pharmacology
Czasopismo naukowe
Tytuł :
Inhibition of human UDP-glucuronosyltransferase enzyme by belinostat: Implications for drug-drug interactions.
Autorzy :
Wang X; School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, China.
Wang Z; School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, China.
Wang Z; School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, China.
Chen X; Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, 215123, China.
Yin H; School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, China.
Jiang L; School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, China.
Cao J; Department of Occupational and Environmental Health, Dalian Medical University, Dalian, 116044, China. Electronic address: .
Liu Y; School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Mar 01; Vol. 338, pp. 51-57. Date of Electronic Publication: 2020 Dec 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Glucuronosyltransferase/*antagonists & inhibitors
Histone Deacetylase Inhibitors/*pharmacology
Hydroxamic Acids/*pharmacology
Sulfonamides/*pharmacology
Administration, Oral ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/toxicity ; Drug Interactions ; Glucuronosyltransferase/metabolism ; Histone Deacetylase Inhibitors/administration & dosage ; Histone Deacetylase Inhibitors/toxicity ; Humans ; Hydroxamic Acids/administration & dosage ; Hydroxamic Acids/toxicity ; Infusions, Intravenous ; Kinetics ; Sulfonamides/administration & dosage ; Sulfonamides/toxicity
Czasopismo naukowe
Tytuł :
HDAC-Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells.
Autorzy :
Liang T; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
Zhou Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
Elhassan RM; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
Hou X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
Yang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
Fang H; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 12083-12099. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetophenones/*pharmacology
Apoptosis/*drug effects
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
bcl-2-Associated X Protein/*metabolism
Acetophenones/chemical synthesis ; Acetophenones/chemistry ; Animals ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; HeLa Cells ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Ligands ; Models, Molecular ; Molecular Structure ; Rabbits ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Vitamin K 3 chloro derivative (VKT-2) inhibits HDAC6, activates autophagy and apoptosis, and inhibits aggresome formation in hepatocellular carcinoma cells.
Autorzy :
Dawood M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany; Department of Molecular Biology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan.
Hegazy MF; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.
Elbadawi M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
Fleischer E; MicroCombiChem GmbH, Wiesbaden, Germany.
Klinger A; MicroCombiChem GmbH, Wiesbaden, Germany.
Bringmann G; Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Kuntner C; AIT Austrian Institute of Technology GmbH, Preclinical Molecular Imaging, Seibersdorf, Austria.
Shan L; The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114176. Date of Electronic Publication: 2020 Jul 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Carcinoma, Hepatocellular/*drug therapy
Histone Deacetylase 6/*antagonists & inhibitors
Histone Deacetylase Inhibitors/*pharmacology
Liver Neoplasms/*drug therapy
Vitamin K 3/*pharmacology
Animals ; Apoptosis/physiology ; Autophagy/physiology ; Carcinoma, Hepatocellular/metabolism ; Cell Aggregation/drug effects ; Cell Aggregation/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; HCT116 Cells ; HEK293 Cells ; Histone Deacetylase 6/metabolism ; Histone Deacetylase Inhibitors/chemistry ; Histone Deacetylase Inhibitors/therapeutic use ; Humans ; Liver Neoplasms/metabolism ; MCF-7 Cells ; Vitamin K 3/chemistry ; Vitamin K 3/therapeutic use ; Xenograft Model Antitumor Assays/methods ; Zebrafish
Czasopismo naukowe
Tytuł :
Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models.
Autorzy :
Noonepalle S; Department of Biochemistry and Molecular Medicine, The George Washington University, Washington, District of Columbia 20052, United States.
Shen S; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
Ptáček J; Laboratory of Structural Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, Vestec 252 50, Czech Republic.
Tavares MT; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
Zhang G; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
Stránský J; Centre of Molecular Structure, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, Vestec 252 50, Czech Republic.
Pavlíček J; Centre of Molecular Structure, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, Vestec 252 50, Czech Republic.
Ferreira GM; Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Hadley M; Department of Biochemistry and Molecular Medicine, The George Washington University, Washington, District of Columbia 20052, United States.
Pelaez G; Department of Biochemistry and Molecular Medicine, The George Washington University, Washington, District of Columbia 20052, United States.
Bařinka C; Laboratory of Structural Biology, Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Prumyslova 595, Vestec 252 50, Czech Republic.
Kozikowski AP; Bright Minds Biosciences, Toronto, ON M5H 3V9, Canada.
Villagra A; Department of Biochemistry and Molecular Medicine, The George Washington University, Washington, District of Columbia 20052, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Sep 24; Vol. 63 (18), pp. 10246-10262. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Histone Deacetylase 6/*antagonists & inhibitors
Histone Deacetylase Inhibitors/*therapeutic use
Hydroxamic Acids/*therapeutic use
Immunologic Factors/*therapeutic use
Melanoma/*drug therapy
Phenylurea Compounds/*therapeutic use
Animals ; Cell Line, Tumor ; Crystallography, X-Ray ; Drug Design ; Female ; Histone Deacetylase 6/metabolism ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/metabolism ; Humans ; Hydrogen Bonding ; Hydroxamic Acids/chemical synthesis ; Hydroxamic Acids/metabolism ; Immunologic Factors/chemical synthesis ; Immunologic Factors/metabolism ; Immunotherapy ; Melanoma/therapy ; Mice, Inbred C57BL ; Microsomes, Liver/metabolism ; Molecular Dynamics Simulation ; Phenylurea Compounds/chemical synthesis ; Phenylurea Compounds/metabolism ; Protein Binding ; Rats
Czasopismo naukowe
Tytuł :
Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups.
Autorzy :
Reßing N; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstr. 34, 04103 Leipzig, Germany.; Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
Sönnichsen M; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
Osko JD; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Schöler A; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstr. 34, 04103 Leipzig, Germany.
Schliehe-Diecks J; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
Skerhut A; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Borkhardt A; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
Hauer J; Department of Pediatrics, Pediatric Hematology and Oncology, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstr. 74, 01307 Dresden, Germany.
Kassack MU; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.
Christianson DW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Bhatia S; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.
Hansen FK; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstr. 34, 04103 Leipzig, Germany.; Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Sep 24; Vol. 63 (18), pp. 10339-10351. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Histone Deacetylase 6/*antagonists & inhibitors
Histone Deacetylase Inhibitors/*pharmacology
Tetrazoles/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Bortezomib/pharmacology ; Cell Line, Tumor ; Daunorubicin/pharmacology ; Drug Screening Assays, Antitumor ; Drug Synergism ; Epirubicin/pharmacology ; Histone Deacetylase 6/metabolism ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/metabolism ; Humans ; Microsomes, Liver/metabolism ; Molecular Structure ; Protein Binding ; Structure-Activity Relationship ; Tetrazoles/chemical synthesis ; Tetrazoles/metabolism
Czasopismo naukowe
Tytuł :
Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy.
Autorzy :
Liu T; Department of Medicinal Chemistry, School of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, Shandong, China.
Wan Y; Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, Hunan, China.
Xiao Y; Department of Medicinal Chemistry, School of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, Shandong, China.
Xia C; Department of Medicinal Chemistry, School of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, Shandong, China.
Duan G; Department of Medicinal Chemistry, School of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, Shandong, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Sep 10; Vol. 63 (17), pp. 8977-9002. Date of Electronic Publication: 2020 Apr 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Antineoplastic Agents/*chemistry
Histone Deacetylase Inhibitors/*chemistry
Histone Deacetylases/*metabolism
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; DNA Damage/drug effects ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylases/chemistry ; Humans ; Neoplasms/drug therapy ; Protein Kinases/chemistry ; Protein Kinases/metabolism ; Protein Kinases/pharmacology ; Proteins/antagonists & inhibitors ; Proteins/metabolism ; Structure-Activity Relationship ; Topoisomerase Inhibitors/chemistry ; Topoisomerase Inhibitors/pharmacology ; Topoisomerase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
Life on the battlefield: Valproic acid for combat applications.
Autorzy :
Russo R; From the Department of Surgery (R.R., M.K., U.F.B., G.W., B.B., H.B.A.), University of Michigan Health System, Ann Arbor, Michigan; United States Air Force, Medical Corps (R.R.), David Grant Medical Center, Travis AFB, California; and Department of Pharmacology (M.P.), University of Michigan, Ann Arbor, Michigan.
Kemp M
Bhatti UF
Pai M
Wakam G
Biesterveld B
Alam HB
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Źródło :
The journal of trauma and acute care surgery [J Trauma Acute Care Surg] 2020 Aug; Vol. 89 (2S Suppl 2), pp. S69-S76.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Military Personnel*
Brain Injuries, Traumatic/*drug therapy
Histone Deacetylase Inhibitors/*therapeutic use
Military Medicine/*methods
Shock, Hemorrhagic/*drug therapy
Valproic Acid/*therapeutic use
War-Related Injuries/*drug therapy
Animals ; Armed Conflicts ; Brain Injuries, Traumatic/mortality ; Gene Expression/drug effects ; Histone Deacetylase Inhibitors/administration & dosage ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Kaplan-Meier Estimate ; Resuscitation ; Shock, Hemorrhagic/mortality ; Valproic Acid/administration & dosage ; Valproic Acid/pharmacology
Czasopismo naukowe
Tytuł :
Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor.
Autorzy :
Chang TC; Department of Medicine, Section of Hematology/Oncology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.
Matossian MD; Department of Medicine, Section of Hematology/Oncology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.
Elliott S; Department of Medicine, Section of Hematology/Oncology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.
Burks HE; Department of Medicine, Section of Hematology/Oncology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.
Sabol RA; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.
Ucar DA; Department of Genetics, Louisiana State University School of Medicine, New Orleans, Louisiana, United States of America.
Wathieu H; Department of Medicine, Section of Hematology/Oncology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.
Zabaleta J; Department of Pediatrics, Louisiana State University School of Medicine, New Orleans, Louisiana, United States of America.
Valle L; Department of Pathology, Louisiana State University School of Medicine, New Orleans, Louisiana, United States of America.
Gill S; Department of Medicine, Section of Hematology/Oncology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.
Martin E; Department of Agricultural Engineering, Louisiana State University, Baton Rouge, Louisiana, United States of America.
Riker AI; Department of Surgery, Louisiana State University School of Medicine, New Orleans, Louisiana, United States of America.
Miele L; Department of Genetics, Louisiana State University School of Medicine, New Orleans, Louisiana, United States of America.
Bunnell BA; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.
Burow ME; Department of Medicine, Section of Hematology/Oncology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.
Collins-Burow BM; Department of Medicine, Section of Hematology/Oncology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Oct 09; Vol. 15 (10), pp. e0226464. Date of Electronic Publication: 2020 Oct 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Breast Neoplasms/*drug therapy
Depsipeptides/*administration & dosage
Histone Deacetylase Inhibitors/*administration & dosage
Lung Neoplasms/*drug therapy
Lung Neoplasms/*secondary
Panobinostat/*administration & dosage
Animals ; Breast Neoplasms/genetics ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Depsipeptides/pharmacology ; Drug Synergism ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Lung Neoplasms/genetics ; Mice ; Middle Aged ; Neoplastic Cells, Circulating/drug effects ; Panobinostat/pharmacology ; Patient-Specific Modeling ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Histone deacetylases inhibitors as new potential drugs against Leishmania braziliensis, the main causative agent of new world tegumentary leishmaniasis.
Autorzy :
Ângelo de Souza L; Departamento de Biologia Geral, Universidade Federal de Viçosa, Minas Gerais, Brazil; Consortium A-ParaDDisE- Anti- Parasite Drug Discovery in Epigenetics - http://a-paraddise.cebio.org. Electronic address: .
Silva E Bastos M; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Brazil; Consortium A-ParaDDisE- Anti- Parasite Drug Discovery in Epigenetics - http://a-paraddise.cebio.org. Electronic address: .
de Melo Agripino J; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Brazil; Consortium A-ParaDDisE- Anti- Parasite Drug Discovery in Epigenetics - http://a-paraddise.cebio.org. Electronic address: .
Souza Onofre T; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Brazil; Consortium A-ParaDDisE- Anti- Parasite Drug Discovery in Epigenetics - http://a-paraddise.cebio.org. Electronic address: .
Apaza Calla LF; Departamento de Biologia Geral, Universidade Federal de Viçosa, Minas Gerais, Brazil; Consortium A-ParaDDisE- Anti- Parasite Drug Discovery in Epigenetics - http://a-paraddise.cebio.org. Electronic address: .
Heimburg T; Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale), Germany. Electronic address: .
Ghazy E; Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale), Germany. Electronic address: .
Bayer T; Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale), Germany. Electronic address: .
Ferraz da Silva VH; Departamento de Biologia Geral, Universidade Federal de Viçosa, Minas Gerais, Brazil. Electronic address: .
Dutra Ribeiro P; Departamento de Biologia Geral, Universidade Federal de Viçosa, Minas Gerais, Brazil. Electronic address: .
Licursi de Oliveira L; Departamento de Biologia Geral, Universidade Federal de Viçosa, Minas Gerais, Brazil. Electronic address: .
Costa Bressan G; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Brazil; Consortium A-ParaDDisE- Anti- Parasite Drug Discovery in Epigenetics - http://a-paraddise.cebio.org. Electronic address: .
de Almeida Lamêgo MR; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Brazil; Consortium A-ParaDDisE- Anti- Parasite Drug Discovery in Epigenetics - http://a-paraddise.cebio.org. Electronic address: .
Silva-Júnior A; Departamento de Veterinária, Universidade Federal de Viçosa, Minas Gerais, Brazil. Electronic address: .
de Souza Vasconcellos R; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Brazil. Electronic address: .
Suarez-Fontes AM; LITEB, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil. Electronic address: .
Almeida-Silva J; LITEB, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil. Electronic address: .
Vannier-Santos MA; LITEB, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil. Electronic address: .
Pierce R; Université de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, 59000 Lille, France; Consortium A-ParaDDisE- Anti- Parasite Drug Discovery in Epigenetics - http://a-paraddise.cebio.org. Electronic address: .
Sippl W; Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle (Saale), Germany; Consortium A-ParaDDisE- Anti- Parasite Drug Discovery in Epigenetics - http://a-paraddise.cebio.org. Electronic address: .
Lopes Rangel Fietto J; Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Brazil; Consortium A-ParaDDisE- Anti- Parasite Drug Discovery in Epigenetics - http://a-paraddise.cebio.org. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114191. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Leishmania braziliensis/*drug effects
Leishmania braziliensis/*enzymology
Leishmaniasis, Cutaneous/*enzymology
Animals ; Cell Survival/drug effects ; Cell Survival/physiology ; Histone Deacetylase Inhibitors/therapeutic use ; Humans ; Leishmania braziliensis/ultrastructure ; Leishmaniasis, Cutaneous/drug therapy ; Leishmaniasis, Cutaneous/pathology ; Macrophages/drug effects ; Macrophages/enzymology ; Macrophages/ultrastructure ; Mice ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/metabolism ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
HDAC inhibitors promote pancreatic stellate cell apoptosis and relieve pancreatic fibrosis by upregulating miR-15/16 in chronic pancreatitis.
Autorzy :
Ji T; Intensive Care Unit, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Beijing West Road, Huaiyin District, Huai'an, 223300, Jiangsu, China.
Feng W; Intensive Care Unit, Huai'an No 4 People's Hospital, 128 Yan'an East Road, Qingjiangpu District, Huai'an, 223002, Jiangsu, China.
Zhang X; Intensive Care Unit, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Beijing West Road, Huaiyin District, Huai'an, 223300, Jiangsu, China.
Zang K; Intensive Care Unit, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Beijing West Road, Huaiyin District, Huai'an, 223300, Jiangsu, China.
Zhu X; Intensive Care Unit, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Beijing West Road, Huaiyin District, Huai'an, 223300, Jiangsu, China.
Shang F; Intensive Care Unit, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Beijing West Road, Huaiyin District, Huai'an, 223300, Jiangsu, China. .
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Źródło :
Human cell [Hum Cell] 2020 Oct; Vol. 33 (4), pp. 1006-1016. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*genetics
Histone Deacetylase Inhibitors/*pharmacology
MicroRNAs/*genetics
MicroRNAs/*metabolism
Pancreas/*pathology
Pancreatic Stellate Cells/*pathology
Pancreatitis, Chronic/*drug therapy
Pancreatitis, Chronic/*genetics
Pancreatitis, Chronic/*pathology
Up-Regulation/*drug effects
Cells, Cultured ; Fibrosis ; Gene Expression/drug effects ; Histone Deacetylase Inhibitors/therapeutic use ; Humans ; Pancreas/metabolism ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Smad Proteins/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of phospholipase D2 augments histone deacetylase inhibitor-induced cell death in breast cancer cells.
Autorzy :
Hwang WC; Department of Molecular Biology, College of Natural Science, Pusan National University, Busan, 609-735, South Korea.; College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, South Korea.
Kang DW; Department of Molecular Biology, College of Natural Science, Pusan National University, Busan, 609-735, South Korea.
Kang Y; College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, South Korea.
Jang Y; Department of Biology and Chemistry, Changwon National University, Changwon, South Korea.
Kim JA; College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, South Korea.
Min DS; College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, South Korea. .
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Źródło :
Biological research [Biol Res] 2020 Oct 01; Vol. 53 (1), pp. 34. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/drug therapy
Histone Deacetylase Inhibitors*/pharmacology
Animals ; Cell Death ; Chick Embryo ; Endothelial Cells ; Humans ; Phospholipase D
Czasopismo naukowe
Tytuł :
Flavonoids potentiated anticancer activity of cisplatin in non-small cell lung cancer cells in vitro by inhibiting histone deacetylases.
Autorzy :
Yan W; School of Pharmacy, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Wu THY; School of Pharmacy, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Leung SSY; School of Pharmacy, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
To KKW; School of Pharmacy, The Chinese University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118211. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Carcinoma, Non-Small-Cell Lung/*enzymology
Cisplatin/*administration & dosage
Flavonoids/*administration & dosage
Histone Deacetylase Inhibitors/*administration & dosage
Lung Neoplasms/*enzymology
A549 Cells ; Antineoplastic Agents/chemistry ; Apigenin/administration & dosage ; Apigenin/chemistry ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Survival/drug effects ; Cell Survival/physiology ; Cisplatin/chemistry ; Dose-Response Relationship, Drug ; Drug Synergism ; Flavonoids/chemistry ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors.
Autorzy :
Nepali K; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taiwan.
Chang TY; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taiwan; Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, College of Pharmacy, Taipei Medical University, Taiwan; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taiwan.
Lai MJ; Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, College of Pharmacy, Taipei Medical University, Taiwan.
Hsu KC; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taiwan; TMU Biomedical Commercialization Center, Taipei Medical University, Taiwan; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taiwan.
Yen Y; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taiwan.
Lin TE; Graduate Institute of Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taiwan.
Lee SB; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taiwan; Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, College of Pharmacy, Taipei Medical University, Taiwan. Electronic address: .
Liou JP; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taiwan; Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taiwan; TMU Biomedical Commercialization Center, Taipei Medical University, Taiwan; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Jun 15; Vol. 196, pp. 112291. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Benzamides/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Purines/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Benzamides/chemical synthesis ; Benzamides/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Hep G2 Cells ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Male ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Docking Simulation ; Molecular Structure ; Purines/chemistry ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe

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